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Bcftools liftover - reference check alwys fails on symbolic variants #1194

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davmlaw opened this issue Nov 8, 2024 · 1 comment
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@davmlaw
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davmlaw commented Nov 8, 2024

I added a check to ensure variant matched reference, but this always fails for symbolic variants as they have a single base ref then symbolic alt, rather than full explicit ref:

Example variant: NC_000001.10:g.145505732_145513588del

{ "error_message": "Validation Error: reference='C' not equal to calculated ref from genome C ....GATCGTGCCAT" }

Symbolic alt will always match reference as I am pulling it out, so we should just skip the check here

@davmlaw
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davmlaw commented Nov 8, 2024

Upon deploy this should fix up anything currently stuck

example on shariant test: NC_000001.10:g.10036359_10043727dup

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