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Update index.Rmd #24

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Expand Up @@ -45,7 +45,7 @@ meta() %>%

*Supports link to vitamin D*

- A [randomized trial](https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3771318) of 930 people found that calcifediol supplementation reduced Covid mortality by 60%. (Nogues et al, February 2021)
- A [randomized trial](https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3771318) of 930 people found that calcifediol supplementation reduced Covid mortality by 60%. (Nogues et al, February 2021). **Results of this trial skeptical since it's analyzed as a RCT but it isn't - it's a cluster RCT but even that's questionable - patients not randomized to clusters. See [this](https://twitter.com/fperrywilson/status/1360944814271979523?s=20) for more**.
- A [parallel pilot randomized open label](https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub#tbl0005) trial of 76 patients in Spain found that the administration of calcifediol reduced ICU admission and mortality. Of the 50 patients treated with calcifediol. 13/26 patients in the control group required ICU care compared with 1 in the intervention group. A [subsequent statistical analysis](https://www.medrxiv.org/content/10.1101/2020.11.08.20222638v1) showed that decreased ICU admissions were not due to uneven distribution of comorbidities or other prognostic indicators, to imperfect blinding, or to chance, but were instead associated with the calcifediol intervention. (Castillo et all, August 2020)
- A randomized, [placebo controlled trial](https://pmj.bmj.com/content/early/2020/11/12/postgradmedj-2020-139065.full) found that therapeutic, high-dose cholecalciferol supplementation led to SARS-CoV-2 RNA negative status in additional 41.7% of mildly symptomatic Covid patients (p\<0.001) and was useful for viral SARS-CoV-2 RNA clearance.

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