COPE is a framework of Context-Oriented Predictor for variant Effect. To the best of our knowledge, COPE is the first fully functional element-centric variant annotation tool that integrates the entire sequence context to evaluate the functional impact of multiple variants in a context-sensitive approach. Different from current variant-centric approach that assesses the functional consequence of each variant independently, COPE takes each functional element as the basic annotation unit and considers that multiple variants in the same functional element may interfere each other and have different effects in combination than individually (complementary rescue effect). Currently, COPE could be applied to both protein-coding gene (PCG) and transcription factor binding site (TFBS).
Please visit http://cope.cbi.pku.edu.cn/
- 20180622 Upload COPE_PCG and COPE_TFBS