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KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (64 sequences, 11 countries) #2796

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Over-There-Is opened this issue Oct 2, 2024 · 12 comments

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@Over-There-Is
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Over-There-Is commented Oct 2, 2024

Transferred from sars-cov-2-variants/lineage-proposals#2026

KP.3.1.1> C1441T> A26760C(M:I80L), G28423C(Orf9b:R47P)
Query: A26760C, G28423C

Earliest sequence: 07-22 New York City, New York, USA EPI_ISL_19310813
Latest sequence: 09-15 England, United Kingdom EPI_ISL_19450681
Regions detected:
Denmark 6, Italy 4(Lazio), Ireland 3(Waterford 2, Dublin 1), Sweden 1(Västra Götaland), UK 1(England);
US 5(Utah 2, Nebraska 1, NJ 1, NY 1), Canada 2(Alberta).

https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_36642_ceaaf0.json?c=country&label=id:node_7192304
image

Sequences:
EPI_ISL_19310813, EPI_ISL_19340122, EPI_ISL_19378173,
EPI_ISL_19378191, EPI_ISL_19378985, EPI_ISL_19410881,
EPI_ISL_19410913, EPI_ISL_19410917, EPI_ISL_19411048,
EPI_ISL_19412118, EPI_ISL_19416249, EPI_ISL_19416902,
EPI_ISL_19416909, EPI_ISL_19420984, EPI_ISL_19426131,
EPI_ISL_19426137, EPI_ISL_19435621, EPI_ISL_19443834,
EPI_ISL_19443868, EPI_ISL_19444024, EPI_ISL_19448830,
EPI_ISL_19450681

@FedeGueli
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FedeGueli commented Oct 2, 2024

25, England

@DailyCovidCases
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33 seqs now please update it @Over-There-Is

@FedeGueli
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38 mainly Denmark but spreading further

@FedeGueli
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40 California, Lombardy (Italy)

@Over-There-Is Over-There-Is changed the title KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (22 sequences, 7 countries) KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (40 sequences, 8 countries) Oct 14, 2024
@Over-There-Is Over-There-Is changed the title KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (40 sequences, 8 countries) KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (40 sequences, 8 countries) and further S:S31F(DK 11) Oct 14, 2024
@Over-There-Is Over-There-Is changed the title KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (40 sequences, 8 countries) and further S:S31F(DK 11) KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (43 sequences, 8 countries) Oct 14, 2024
@Over-There-Is
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3 american sequences not on gisaid

@Over-There-Is
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lots of danish sequences have artefactual S:31P instead of 31-

@FedeGueli
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FedeGueli commented Oct 14, 2024

lots of danish sequences have artefactual S:31P instead of 31-

a bit weird because they usually reads it as S:31F, could be a nuc mutation nearby?

@Over-There-Is
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typo, 31F

@FedeGueli
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50, one recent sample from Sweden had Spike_P337S that is a Sotrovimab escape mutation i think

@Over-There-Is Over-There-Is changed the title KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (43 sequences, 8 countries) KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (52 sequences, 10 countries) Oct 23, 2024
@Over-There-Is
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netherlands, slovakia

@Over-There-Is Over-There-Is changed the title KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (52 sequences, 10 countries) KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (57 sequences, 10 countries) Oct 26, 2024
@Over-There-Is Over-There-Is changed the title KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (57 sequences, 10 countries) KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (61 sequences, 11 countries) Oct 30, 2024
@Over-There-Is
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Germany

@Over-There-Is Over-There-Is changed the title KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (61 sequences, 11 countries) KP.3.1.1 subbranch with M:I80L, Orf9b:R47P (64 sequences, 11 countries) Oct 30, 2024
@FedeGueli
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Likely the most interesting not spike mutated branch of Kp.3.1.1 cc @corneliusroemer

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