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Add note about grpmax #1290

Merged
merged 9 commits into from
Nov 16, 2023
Merged

Add note about grpmax #1290

merged 9 commits into from
Nov 16, 2023

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ch-kr
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@ch-kr ch-kr commented Nov 14, 2023

Added note that grpmax does not contain filtering allele frequency. Looking at this again, should we just remove grpmax text from the faf md?

browser/help/topics/faf.md Outdated Show resolved Hide resolved
@@ -9,10 +9,4 @@ Note that this annotation contains filtering allele frequency information from t

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"Note that this annotation contains filtering allele frequency information from the genetic ancestry group with the highest FAF"

We should clarify that this part is referring to the grpmax faf (or whatever we settled on for a name) and not just faf

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will add a sentence -- let me know what you think

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L8: "this annotation" -> " the GroupMax FAF"

This annotation (abbreviated "`grpmax`") contains allele frequency information (AC, AN, AF, homozygote count) for the non-bottlenecked genetic ancestry groups with the highest **AF**.

For gnomAD v4, this calculation excludes Amish (`ami`), Ashkenazi Jewish (`asj`), European Finnish (`fin`), Middle Eastern (`mid`), and "Remaining Individuals" (`rmi`) groups. For gnomAD v2, this calculation excludes Ashkenazi Jewish (`asj`), European Finnish (`fin`), and "Remaining Individuals" (`rmi`) groups.
On the browser, this annotation is directly available on the variant page. In the VCF and Hail Tables, this annotation (abbreviated "`faf`") is computed globally and for each genetic ancestry group. Filtering allele frequencies (FAFs) for each genetic ancestry group specific are listed separately with 95% and 99% CIs.
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should clarify that grpmax faf is on the brower, but all faf is in the Tables

or maybe change the id to grpmax faf and edit some of the text?

@ch-kr ch-kr requested a review from klaricch November 14, 2023 16:22
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just one small thing

@@ -9,10 +9,4 @@ Note that this annotation contains filtering allele frequency information from t

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L8: "this annotation" -> " the GroupMax FAF"

@ch-kr ch-kr requested a review from klaricch November 14, 2023 18:31
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@rileyhgrant rileyhgrant left a comment

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LGTM, will merge this via a squash commit to keep the commit history a cleaner.

@rileyhgrant rileyhgrant merged commit 9797aca into main Nov 16, 2023
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@rileyhgrant rileyhgrant deleted the faf branch November 16, 2023 12:55
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3 participants