Type 2 Diabetes Pathways

Matlab and xpp files for Pathways to Diabetes Model

This is supplementary material for:

J. Ha and A. Sherman. 2019. Type 2 Diabetes: One Disease, Many Pathways [PubMed].

Matlab equation definition file for all figures except Figs. 9 and S15:

pathway.m

Matlab equation definition files for Figs. 9 and S15:

pathway_FIG9.m

pathway_FIGS15.m

Matlab run files for individual figures:

Figures 1 - 4. Matlab will generate Fig1 - Fig6, corresponding to Panels A - F (a counter will tick off 365 iterations):

Figure 1: FIG1.m

Figure 2: FIG2.m

Figure 3: FIG3.m

Figure 4: FIG4.m

Figures 6, 7. Matlab will generate Panels A, B (IGT first case):

Figure 6: FIG6.m

Figure 7: FIG7.m

Supplemental Figures

FigS8: FIGS8.m

FigS9: FIGS9.m

FigS10: FIGS10.m

FigS11: FIGS11.m

FigS12: FIGS12.m

FigS13: FIGS13.m

FigS14: FIGS14.m

FigS14: FIGS15.m

XPP source file for all figures except Figs. 9, S10 and S11:

pathway.ode: pathway.ode

XPP source files Figs. 9, S10 and S11:

pathway_FIG9.ode (insulin reistance induced by insulin): pathway_FIG9.ode

pathway_FIGS10_11.ode (non-insulin dependent glucose uptake): pathway_FIGS10_11.ode

XPP set files for individual figures:

Figures 1 - 4. xpp will plot the longitudinal response of glucose to meals each day. The envelope of the plot will show the fasting and peak postprandial values. Use the xpp menus to display the other variables:

FIG1.set (IGT-first pathway): FIG1.set

FIG2.set (Sustained IGT): FIG2.set

FIG3.set (IFG-first pathway IGT): FIG3.set

FIG4.set (IGT without CGI): FIG4.set

FIG9_no_cl_no_FE.set (default IGT-first pathway; use pathway_FIG9.ode): FIG9_no_cl_no_FE.set

FIG9_modest_cl_FE.set (reduced clearance delays T2D; use pathway_FIG9.ode): FIG9_modest_cl_FE.set

FIG9_balanced_cl_FE.set (reduced clearance and induced resistance cancel out; use pathway_FIG9.ode): FIG9_balanced_cl_FE.set

FIG9_extreme_cl_FE.set (reduced clearance and severe induced resistance accelerates T2D; use pathway_FIG9.ode): FIG9_extreme_cl_FE.set

Supplemental Figures

FIGS8.set (mild GOF KATP defect): FIGS8.set

FIGS9.set: (severe GOF KATP defect): FIGS9.set

FIGS10.set (impaired glucose effectiveness; use pathway_FIGS10_11.ode): FIGS10.set

FIGS11.set (enhanced glucose effectiveness; use pathway_FIGS10_11.ode): FIGS11.set

FIGS12_fast_si.set (IGT-first pathway, same as Fig. 1): FIGS12_fast_si.set

FIGS12_slow_si.set (protected from T2D): FIGS12_slow_si.set

FIGS13.set (IFG-first pathway driven by GOF KATP defect): FIGS13.set

FIGS14.set: (IFG-first pathway driven by impaired vesicle trafficking - small RRP): FIGS14.set

FIGS15.set (impaired incretin signaling accelerates T2D): FIGS15.set