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removed unnecessary fields
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JordanBrooks33 committed Jun 18, 2024
1 parent 5465d29 commit 0203ba5
Showing 1 changed file with 0 additions and 35 deletions.
35 changes: 0 additions & 35 deletions inst/models/pk_pegasparaginase_modified_wurthwein.json5
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{
"id": "pk_pegasparaginase_modified_wurthwein",
"description": "PK model for PEG-asparagainase children",
"drug": "peg-asparaginase",
"category": "oncology",
"age_categories": [ "children" ],
"equations": [
],
"ode_code": "\
dAdt[0] = - (CLi/Vi + Qi/Vi) * A[0] \
dAdt[1] = + (Qi/Vi)*A[0] - (CLi/Vi + Qi/Vi)*A[1] \
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"timevarying_parameter": false,
"init_parameter": false
},
"development": {
"n_patients": 1374,
"n_tdms": 6069,
"age": { "median": 5.13, "minimum": 1.03 , "maximum": 17.9 , "unit": "years" },
"weight": { "median": 19.55, "minimum": 8.5 , "maximum": 128, "unit": "kg" },
"height": { "median": 113, "minimum": 71, "maximum": 195, "unit": "cm" },
"sex": { "male": 779, "female": 595}
},
"external_validation": [],
"references": [
{
"ref": "Würthwein et al. European Journal of Drug Metabolism and Pharmacokinetics. 2021",
"url": "https://link.springer.com/article/10.1007/s13318-021-00670-8#Sec181"
}
],
"active": true,
"build": true,
"admin": [
{
"implementer": { "name": "Jordan Brooks", "email": "[email protected]" },
"format": "PKPDsim"
},
{
"implementer": { "name": "Jordan Brooks", "email": "[email protected]" },
"format": "NONMEM"
}
],
"implementations": {
"nonmem": "pk_pegasparaginase_modified_wurthwein.mod"
},
"comments": [
"Utilizing updated/simplified model from 2021 publication.",
"Removed IOV and specific occasion effects on CL & V, which were specific to the trial and not generalizable to real-world application.",
"Re-estimated IIV on CLP, which was much larger than original publication. Larger IIV is in line with literature and clinical understanding about high variability in peg-asparaginase PK."
],
"validation": {
"implementation": true,
"numerical": true,
"clinical": false
},
"version": "0.1.4"
}

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