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EPICON.Mycobiome

Contact: Cheng Gao

University of California Berkeley

twitter: @chenggucb

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The codes were used in the analysis of Mycobiome data generated from EPICON project.

EPICON is a DOE funded project conceived of by Peggy G. Lemaux, Devin Coleman-Derr, Elizabeth Purdom, John Vogel, Jeffery A. Dahlberg and John W. Taylor, with Peggy G. Lemaux as director. EPICON aimed at understanding responses of sorghum to drought, from host gene expression to host-associated microbiome.

For detailed descriptions of experimental design, please see associated publications:

        Gao et al Nature Communications 2020 Fungal community assembly in drought stressed sorghum shows stochasticity, selection, and universal ecological dynamics https://www.nature.com/articles/s41467-019-13913-9
  
        Gao et al ISMEJ 2019 Strong succession in arbuscular mycorrhizal fungal communities  https://www.nature.com/articles/s41396-018-0264-0 
        
        Varoquaux#, Cole#, Gao# et al PNAS 2019 Transcriptomic analysis of field-droughted sorghum from seedling to maturity reveals biotic and metabolic responses www.pnas.org/cgi/doi/10.1073/pnas.1907500116
        
        Xu et al PNAS 2018 Drought delays development of the sorghum root microbiome and enriches for monoderm bacteria  https://www.pnas.org/content/115/18/E4284

Briefly, we collected 1026 sample from three treatments, two sorghum culrivars, 17 time points and four compartments.

        Three treatments: control, pre-flowering drought and post-flowering drought
  
        Two sorghum cultivars: the pre-flowering, drought tolerant sorghum cultivar RTx430, and the post-flowering, drought tolerant (or ‘stay green’) cultivar BTx642
  
        Four compartments: Leaf, Root, Rhizosphere, Soil

Fungal community compositon and abundance was recognized by:

        Illumina Miseq sequencing of fungal ITS2 rDNA region using 5.8SFun and ITS4Fun primers of the leaf, root, rhizosphere and soil
  
        Illumina Miseq sequencing of fungal ITS2 region for 26 air samples.
  
        qPCR of fungal 18S rRNA region using FF2 and FR1 primers of leaf and root samples
  
        Fungal transcripts in transcriptomes containing both sorghum plants and their fungi generated from leaf and root samples

Fungal community assembly was explored by:

        Multivariate analysis such as PCoA, adonis, betadispersion
  
        Raup-Crick index and Beta Nearest Taxon Index 
  
        Dissimilarity Overlap Curve
  
        etc...

Here is the link for the dataset EPICON.data.preparation.RC.bNTI.ted.2019.04.19.Rdata : https://drive.google.com/file/d/1A6xcn28-HB5oaA8tCdlTiGIuVb8Irx8e/view?usp=sharing

Here is the link for the dataset EPICON.DOC.2018.05.24.Rdata : https://drive.google.com/file/d/1It71FSp8KDC2-UlcjsKfH4MhBe3Mc1gR/view?usp=sharing

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