diff --git a/modules/nanopb/CMakeLists.txt b/modules/nanopb/CMakeLists.txt
index 2520595cf94f28..0e7ea4c793d3c2 100644
--- a/modules/nanopb/CMakeLists.txt
+++ b/modules/nanopb/CMakeLists.txt
@@ -38,6 +38,11 @@ if(CONFIG_NANOPB)
     PB_WITHOUT_64BIT
   )
 
+  zephyr_compile_definitions_ifdef(
+    CONFIG_NANOPB_NO_ENCODE_SIZE_CHECK
+    PB_NO_ENCODE_SIZE_CHECK
+  )
+
   zephyr_compile_definitions_ifdef(
     CONFIG_NANOPB_ENCODE_ARRAYS_UNPACKED
     PB_ENCODE_ARRAYS_UNPACKED
diff --git a/modules/nanopb/Kconfig b/modules/nanopb/Kconfig
index 41030eac6b3e7a..5c415657ca07aa 100644
--- a/modules/nanopb/Kconfig
+++ b/modules/nanopb/Kconfig
@@ -42,6 +42,12 @@ config NANOPB_WITHOUT_64BIT
 	  Disable support of 64-bit integer fields, for old compilers or
 	  for a slight speedup on 8-bit platforms.
 
+config NANOPB_NO_ENCODE_SIZE_CHECK
+	bool "Disable size checks when encoding sub-messages"
+	help
+	  Disable checking the size of encoded submessages between initial sizing
+	  encoding and final encoding to the stream.
+
 config NANOPB_ENCODE_ARRAYS_UNPACKED
 	bool "Encode arrays unpacked"
 	help