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About integrin genes from the output #188
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Hi @Pedramto89, Could you show us how your results look like? Then we can better provide a way to find the genes that you're interested in. You can also check CellPhoneDB data and search for integrin as I mentioned similarly in #187. Best, |
Hi @Pedramto89, "complex_input" of CellPhoneDB data has the information about complexes including integrins, they can be found by searching from the CellPhoneDB page. I've also extracted integrins from "complex_input" in this file: v5.0.0_complex_input_integrin.xlsx Here you can find the parts of the complexes, however they are stored as UniPort IDs. You can check UniProt website for which genes each UniProt ID corresponds to. For instance: "integrin_a10b1_complex" has P05556 and O75578. Hope this helps you!! Best, |
Regarding to the visualisations, I assume the scores were normalised and that should be why you probably have the negative values. If this is the case, negative scores can be interpreted as less strong interaction compared to general. Best, |
Thank you Batu for your prompt response. In the meantime you responded, I was trying to go over the interactions. What I understood from your response is that I should look up every single complex in the Uniprot e.g., and then see which integrin gene has been involved? Is not a time-consuming procedure? |
Hi @Pedramto89,
Best, |
Thanks @cakirb for your response. I am still dig into the results. I would like to know which partner is receptor and which partner is ligand. In the results, I can see there are two columns. One is receptor_a and the other is receptor_b. In some cases which sounds weird to me is that for both partners it is FALSE or for both it is TRUE. Would you explain what does it mean? |
Hi @Pedramto89, It is possible to see the cases where the receptor_a and receptor_b columns are both TRUE or both FALSE. For instance, both receptor_a and receptor_b can be FALSE if they are extracellular matrix proteins, and both can be TRUE when both can act as receptors and trigger responses in the corresponding cells (e.g. HBEGF-ERBB2 -- note HBEGF is transmembrane). Hope this helps! Best, |
Hi I have similar questions, I don't understand why sometimes one of gene_a and gene_b is missing. And I do also have some cases that both of them missing (does not have any gene symbols stated in those columns). |
Empty entries for column gene_a/gene_b correspond to complexes, |
Hi there
I have the results from the CPDB and in several rows within the genes columns, there are 'integrin'. I'd like to know which integrin gene is that? As you know, there are several integrin genes like ITGA1, ITGA2, etc. This is so important for me to evaluate the enrichment of the genes involved in the analysis between cells.
Best
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