diff --git a/Snakefile b/Snakefile
index fe6da1e..81b6599 100644
--- a/Snakefile
+++ b/Snakefile
@@ -127,7 +127,6 @@ rule all:
         f"work/annos/grch38/seqvars/gnomad_mtdna/{DV.gnomad_mtdna}/gnomad_mtdna.vcf.gz",
         f"work/download/annos/grch38/seqvars/gnomad_exomes/{DV.gnomad_v4}/.done",
         f"work/download/annos/grch38/seqvars/gnomad_genomes/{DV.gnomad_v4}/.done",
-        # NB: gnomAD-SV GRCh38 was announced end of 2020 but not released yet
         # -- genome browser "features" (position-specific)
         # ---- GRCh37
         f"work/annos/grch37/features/cons/{DV.ucsc_cons_37}/ucsc_conservation.tsv",
@@ -181,10 +180,6 @@ rule all:
         # ----- genes
         f"output/full/annonars/genes-{DV.acmg_sf}+{DV.gnomad_constraints}+{DV.dbnsfp}+{DV.hpo}+{DV.today}+{PV.annonars}/rocksdb/IDENTITY",
         # -- worker data
-        f"output/full/worker/genes-regions-grch37-{DV.refseq_37}+{PV.worker}/refseq_genes.bin",
-        f"output/full/worker/genes-regions-grch37-{DV.ensembl_37}+{PV.worker}/ensembl_genes.bin",
-        f"output/full/worker/genes-regions-grch38-{DV.refseq_38}+{PV.worker}/refseq_genes.bin",
-        f"output/full/worker/genes-regions-grch38-{DV.ensembl_38}+{PV.worker}/ensembl_genes.bin",
         f"output/full/worker/genes-xlink-{DV.today}+{PV.worker}/genes-xlink.bin",
         f"output/full/worker/acmg-sf-{DV.acmg_sf}+{PV.worker}/acmg_sf.tsv",
         f"output/full/worker/mim2gene-{DV.today}+{PV.worker}/mim2gene.tsv",
@@ -200,6 +195,8 @@ rule all:
         f"output/full/worker/bgdb-dgv-gs-grch38-{DV.dgv}+{PV.worker}/bgdb-dgv-gs.bin",
         f"output/full/worker/bgdb-gnomad-grch37-{DV.gnomad_sv}+{PV.worker}/bgdb-gnomad.bin",
         f"output/full/worker/bgdb-exac-grch37-{DV.exac_cnv}+{PV.worker}/bgdb-exac.bin",
+        f"output/full/worker/bgdb-gnomad-exomes-cnv-grch38-{DV.gnomad_sv4}+{PV.worker}/bgdb-gnomad-exomes-cnv-grch38.bin",
+        f"output/full/worker/bgdb-gnomad-genomes-sv-grch38-{DV.gnomad_sv4}+{PV.worker}/bgdb-gnomad-genomes-sv-grch38.bin",
         f"output/full/worker/bgdb-g1k-grch37-{DV.g1k_svs}+{PV.worker}/bgdb-g1k.bin",
         f"output/full/worker/clinvar-strucvars-grch37-{DV.clinvar_version}+{PV.worker}/clinvar-strucvars.bin",
         f"output/full/worker/clinvar-strucvars-grch38-{DV.clinvar_version}+{PV.worker}/clinvar-strucvars.bin",
@@ -227,6 +224,8 @@ rule all:
         f"output/full/tracks/track-strucvars-exac-grch37-{DV.exac_cnv}+{DV.tracks}/exac.bed.gz",
         f"output/full/tracks/track-strucvars-g1k-grch37-{DV.g1k_svs}+{DV.tracks}/g1k.bed.gz",
         f"output/full/tracks/track-strucvars-gnomad-grch37-{DV.gnomad_sv}+{DV.tracks}/gnomad.bed.gz",
+        f"output/full/tracks/track-strucvars-gnomad-sv-grch38-{DV.gnomad_sv4}+{DV.tracks}/gnomad-sv.bed.gz",
+        f"output/full/tracks/track-strucvars-gnomad-cnv-grch38-{DV.gnomad_cnv4}+{DV.tracks}/gnomad-cnv.bed.gz",
         # ----- known pathogenic MMS
         f"output/full/tracks/track-strucvars-patho-mms-grch37-{DV.patho_mms}+{DV.tracks}/patho-mms.bed",
         f"output/full/tracks/track-strucvars-patho-mms-grch38-{DV.patho_mms}+{DV.tracks}/patho-mms.bed",
@@ -408,7 +407,6 @@ include: "rules/output/annonars/regions.smk"
 # ---- worker
 include: "rules/output/worker/patho_mms.smk"
 include: "rules/output/worker/clinvar.smk"
-include: "rules/output/worker/genes_regions.smk"
 include: "rules/output/worker/hgnc.smk"
 include: "rules/output/worker/acmg.smk"
 include: "rules/output/worker/mim2gene.smk"
diff --git a/download_urls.yml b/download_urls.yml
index 4b3ecea..0f86ab9 100644
--- a/download_urls.yml
+++ b/download_urls.yml
@@ -105,29 +105,101 @@
     strategy: gz-head
     count: 160
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr1.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr2.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr3.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr4.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr5.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr6.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr7.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr8.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr9.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr10.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr11.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr12.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr13.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr14.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr15.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr16.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr17.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr18.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr19.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr20.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr21.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr22.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chrX.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chrY.vcf.gz
+  excerpt_strategy:
+    strategy: vcf-head
+    count: 1800
 
 - url: https://www.deciphergenomics.org/files/downloads/HI_Predictions_Version3.bed.gz
 
@@ -157,13 +229,9 @@
   url: https://search.clinicalgenome.org/kb/reports/curation-activity-summary-report
   skip_upstream_check: true  # does not work reliably in tests
 
-- url: https://github.com/bihealth/annonars-data-clinvar/releases/download/clinvar-weekly-20230625/clinvar-strucvar-grch37-2023-0625+0.6.3.tar.gz
+- url: https://github.com/varfish-org/clinvar-data-jsonl/releases/download/clinvar-weekly-20240612/clinvar-data-extract-vars-20240612+0.17.0.tar.gz
   excerpt_strategy:
-    strategy: no-excerpt
-    count: null
-- url: https://github.com/bihealth/annonars-data-clinvar/releases/download/clinvar-weekly-20230625/clinvar-strucvar-grch38-2023-0625+0.6.3.tar.gz
-  excerpt_strategy:
-    strategy: no-excerpt
+    strategy: manual
     count: null
 
 - url: https://github.com/bihealth/mehari-data-tx/releases/download/v0.4.4/mehari-data-txs-grch37-0.4.4.bin.zst
diff --git a/environment.yml b/environment.yml
index 5e552bb..fc74e6d 100644
--- a/environment.yml
+++ b/environment.yml
@@ -46,7 +46,7 @@ dependencies:
   - annonars =0.34.0
   - viguno =0.2.0
   - mehari =0.21.1
-  - varfish-server-worker =0.10.2
+  - varfish-server-worker =0.12.0
   # S3 uploads
   - s5cmd =2.1.0
   # async HTTP requests
diff --git a/excerpt-data/05e93e6f1f5d60e6/gnomad.v4.0.sv.chr4.vcf.gz b/excerpt-data/05e93e6f1f5d60e6/gnomad.v4.0.sv.chr4.vcf.gz
index fb9a00e..9bfb658 100644
--- a/excerpt-data/05e93e6f1f5d60e6/gnomad.v4.0.sv.chr4.vcf.gz
+++ b/excerpt-data/05e93e6f1f5d60e6/gnomad.v4.0.sv.chr4.vcf.gz
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diff --git a/excerpt-data/05e93e6f1f5d60e6/gnomad.v4.0.sv.chr4.vcf.gz.tbi b/excerpt-data/05e93e6f1f5d60e6/gnomad.v4.0.sv.chr4.vcf.gz.tbi
index ad46be9..3ac5653 100644
--- a/excerpt-data/05e93e6f1f5d60e6/gnomad.v4.0.sv.chr4.vcf.gz.tbi
+++ b/excerpt-data/05e93e6f1f5d60e6/gnomad.v4.0.sv.chr4.vcf.gz.tbi
@@ -1,3 +1,3 @@
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diff --git a/excerpt-data/0be9b2561c9397f2/gnomad.v4.0.sv.chr15.vcf.gz b/excerpt-data/0be9b2561c9397f2/gnomad.v4.0.sv.chr15.vcf.gz
index 6653e09..559d895 100644
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+++ b/excerpt-data/0be9b2561c9397f2/gnomad.v4.0.sv.chr15.vcf.gz
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diff --git a/excerpt-data/0be9b2561c9397f2/gnomad.v4.0.sv.chr15.vcf.gz.tbi b/excerpt-data/0be9b2561c9397f2/gnomad.v4.0.sv.chr15.vcf.gz.tbi
index ae0fcdb..00507e9 100644
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+++ b/excerpt-data/0be9b2561c9397f2/gnomad.v4.0.sv.chr15.vcf.gz.tbi
@@ -1,3 +1,3 @@
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diff --git a/excerpt-data/13d4b1406e769b80/gnomad.v4.0.sv.chr3.vcf.gz b/excerpt-data/13d4b1406e769b80/gnomad.v4.0.sv.chr3.vcf.gz
index aac91a5..ac3e23b 100644
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+++ b/excerpt-data/13d4b1406e769b80/gnomad.v4.0.sv.chr3.vcf.gz
@@ -1,3 +1,3 @@
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+size 6409154
diff --git a/excerpt-data/13d4b1406e769b80/gnomad.v4.0.sv.chr3.vcf.gz.tbi b/excerpt-data/13d4b1406e769b80/gnomad.v4.0.sv.chr3.vcf.gz.tbi
index cad8f87..d30c9bb 100644
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+++ b/excerpt-data/13d4b1406e769b80/gnomad.v4.0.sv.chr3.vcf.gz.tbi
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diff --git a/excerpt-data/182806147755e799/gnomad.v4.0.sv.chr5.vcf.gz b/excerpt-data/182806147755e799/gnomad.v4.0.sv.chr5.vcf.gz
index d4f3d44..76ce903 100644
--- a/excerpt-data/182806147755e799/gnomad.v4.0.sv.chr5.vcf.gz
+++ b/excerpt-data/182806147755e799/gnomad.v4.0.sv.chr5.vcf.gz
@@ -1,3 +1,3 @@
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diff --git a/excerpt-data/182806147755e799/gnomad.v4.0.sv.chr5.vcf.gz.tbi b/excerpt-data/182806147755e799/gnomad.v4.0.sv.chr5.vcf.gz.tbi
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+++ b/excerpt-data/182806147755e799/gnomad.v4.0.sv.chr5.vcf.gz.tbi
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diff --git a/excerpt-data/19a12d845df10514/gnomad.v4.0.sv.chr18.vcf.gz b/excerpt-data/19a12d845df10514/gnomad.v4.0.sv.chr18.vcf.gz
index 6ec4dbd..bf2caf5 100644
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+++ b/excerpt-data/19a12d845df10514/gnomad.v4.0.sv.chr18.vcf.gz
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diff --git a/excerpt-data/19a12d845df10514/gnomad.v4.0.sv.chr18.vcf.gz.tbi b/excerpt-data/19a12d845df10514/gnomad.v4.0.sv.chr18.vcf.gz.tbi
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diff --git a/excerpt-data/2245e9d640b3f206/gnomad.v4.0.sv.chrX.vcf.gz b/excerpt-data/2245e9d640b3f206/gnomad.v4.0.sv.chrX.vcf.gz
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diff --git a/excerpt-data/2245e9d640b3f206/gnomad.v4.0.sv.chrX.vcf.gz.tbi b/excerpt-data/2245e9d640b3f206/gnomad.v4.0.sv.chrX.vcf.gz.tbi
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diff --git a/excerpt-data/2c4af2ee68c51be6/clinvar-strucvar-grch38-2023-0625+0.6.3.tar.gz b/excerpt-data/2c4af2ee68c51be6/clinvar-strucvar-grch38-2023-0625+0.6.3.tar.gz
deleted file mode 100644
index f57bdf0..0000000
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+++ /dev/null
@@ -1,3 +0,0 @@
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deleted file mode 100644
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diff --git a/excerpt-data/ca218c36ad8374d2/gnomad.v4.0.sv.chr14.vcf.gz.tbi b/excerpt-data/ca218c36ad8374d2/gnomad.v4.0.sv.chr14.vcf.gz.tbi
index a6a7b00..b9b01d1 100644
--- a/excerpt-data/ca218c36ad8374d2/gnomad.v4.0.sv.chr14.vcf.gz.tbi
+++ b/excerpt-data/ca218c36ad8374d2/gnomad.v4.0.sv.chr14.vcf.gz.tbi
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deleted file mode 100644
index 6f288ed..0000000
--- a/excerpt-data/d344a91c116abfac/clinvar-strucvar-grch37-2023-0625+0.6.3.tar.gz
+++ /dev/null
@@ -1,3 +0,0 @@
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deleted file mode 100644
index 1d750d3..0000000
--- a/excerpt-data/d344a91c116abfac/url.txt
+++ /dev/null
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index 4d7d200..48ac1a7 100644
--- a/excerpt-data/ec5c8ad8a9c29dd0/gnomad.v4.0.sv.chr12.vcf.gz
+++ b/excerpt-data/ec5c8ad8a9c29dd0/gnomad.v4.0.sv.chr12.vcf.gz
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diff --git a/excerpt-data/ec5c8ad8a9c29dd0/gnomad.v4.0.sv.chr12.vcf.gz.tbi b/excerpt-data/ec5c8ad8a9c29dd0/gnomad.v4.0.sv.chr12.vcf.gz.tbi
index 8978e7c..d316b5d 100644
--- a/excerpt-data/ec5c8ad8a9c29dd0/gnomad.v4.0.sv.chr12.vcf.gz.tbi
+++ b/excerpt-data/ec5c8ad8a9c29dd0/gnomad.v4.0.sv.chr12.vcf.gz.tbi
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index dcd5648..a2735d9 100644
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+++ b/excerpt-data/eed573336b6205b5/gnomad.v4.0.sv.chr19.vcf.gz
@@ -1,3 +1,3 @@
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+size 6508922
diff --git a/excerpt-data/eed573336b6205b5/gnomad.v4.0.sv.chr19.vcf.gz.tbi b/excerpt-data/eed573336b6205b5/gnomad.v4.0.sv.chr19.vcf.gz.tbi
index e510d68..36d0876 100644
--- a/excerpt-data/eed573336b6205b5/gnomad.v4.0.sv.chr19.vcf.gz.tbi
+++ b/excerpt-data/eed573336b6205b5/gnomad.v4.0.sv.chr19.vcf.gz.tbi
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index e4a5ee8..881cc90 100644
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+++ b/excerpt-data/ef1e660e8e0359bc/gnomad.v4.0.sv.chr1.vcf.gz
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+size 6661068
diff --git a/excerpt-data/ef1e660e8e0359bc/gnomad.v4.0.sv.chr1.vcf.gz.tbi b/excerpt-data/ef1e660e8e0359bc/gnomad.v4.0.sv.chr1.vcf.gz.tbi
index 48ced38..cca55c5 100644
--- a/excerpt-data/ef1e660e8e0359bc/gnomad.v4.0.sv.chr1.vcf.gz.tbi
+++ b/excerpt-data/ef1e660e8e0359bc/gnomad.v4.0.sv.chr1.vcf.gz.tbi
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index c901c95..eade6bd 100644
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index b2b0386..72d64df 100644
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index 91548ba..94dbf3d 100644
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+++ b/excerpt-data/fe2a55106424e727/gnomad.v4.0.sv.chr8.vcf.gz
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diff --git a/excerpt-data/fe2a55106424e727/gnomad.v4.0.sv.chr8.vcf.gz.tbi b/excerpt-data/fe2a55106424e727/gnomad.v4.0.sv.chr8.vcf.gz.tbi
index c3cb02d..2e273a7 100644
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+++ b/excerpt-data/fe2a55106424e727/gnomad.v4.0.sv.chr8.vcf.gz.tbi
@@ -1,3 +1,3 @@
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diff --git a/rules/output/worker/bgdb.smk b/rules/output/worker/bgdb.smk
index 1fcf0d0..3caf612 100644
--- a/rules/output/worker/bgdb.smk
+++ b/rules/output/worker/bgdb.smk
@@ -9,10 +9,10 @@ rule output_worker_bgdb_g1k:
         spec=f"output/full/worker/bgdb-g1k-grch37-{{version}}+{PV.worker}/bgdb-g1k.spec.yaml",
     shell:
         r"""
-        varfish-server-worker db to-bin \
+        varfish-server-worker strucvars txt-to-bin \
             --input-type strucvar-g1k \
             --path-input {input.bed} \
-            --path-output-bin {output.bin}
+            --path-output {output.bin}
 
         varfish-db-downloader tpl \
             --template rules/output/worker/bgdb.spec.yaml \
@@ -40,10 +40,10 @@ rule output_worker_bgdb_exac:
         spec=f"output/full/worker/bgdb-exac-grch37-{{version}}+{PV.worker}/bgdb-exac.spec.yaml",
     shell:
         r"""
-        varfish-server-worker db to-bin \
+        varfish-server-worker strucvars txt-to-bin \
             --input-type strucvar-exac-cnv \
             --path-input {input.bed} \
-            --path-output-bin {output.bin}
+            --path-output {output.bin}
 
         varfish-db-downloader tpl \
             --template rules/output/worker/bgdb.spec.yaml \
@@ -63,7 +63,38 @@ rule output_worker_bgdb_exac:
         """
 
 
-rule output_worker_bgdb_gnomad:
+rule output_worker_bgdb_gnomad_exomes_cnv_grch38:
+    input:
+        bed=f"output/full/tracks/track-strucvars-gnomad-cnv-grch38-{{version}}+{DV.tracks}/gnomad-cnv.bed.gz",
+    output:
+        bin=f"output/full/worker/bgdb-gnomad-exomes-cnv-grch38-{{version}}+{PV.worker}/bgdb-gnomad-exomes-cnv-grch38.bin",
+        spec=f"output/full/worker/bgdb-gnomad-exomes-cnv-grch38-{{version}}+{PV.worker}/bgdb-gnomad-exomes-cnv-grch38.spec.yaml",
+    shell:
+        r"""
+        varfish-server-worker strucvars txt-to-bin \
+            --input-type strucvar-gnomad-cnv4 \
+            --path-input {input.bed} \
+            --path-output {output.bin}
+
+        varfish-db-downloader tpl \
+            --template rules/output/worker/bgdb.spec.yaml \
+            \
+            --value db_name=gnomad-exomes-cnv \
+            --value title="gnomAD Exomes CNV" \
+            --value creator="gnomAD Consortium" \
+            --value source="https://gnomad.broadinstitute.org/downloads#v4-copy-number-variants" \
+            \
+            --value version={wildcards.version}+{PV.worker} \
+            --value today={TODAY} \
+            --value genome_release=grch38 \
+            \
+            --value v_worker={PV.worker} \
+            --value v_downloader={PV.downloader} \
+        > {output.spec}
+        """
+
+
+rule output_worker_bgdb_gnomad_sv_grch37:
     input:
         bed=f"output/full/tracks/track-strucvars-gnomad-grch37-{{version}}+{DV.tracks}/gnomad.bed.gz",
     output:
@@ -71,11 +102,10 @@ rule output_worker_bgdb_gnomad:
         spec=f"output/full/worker/bgdb-gnomad-grch37-{{version}}+{PV.worker}/bgdb-gnomad.spec.yaml",
     shell:
         r"""
-        varfish-server-worker db to-bin \
-            --input-type strucvar-gnomad-sv \
+        varfish-server-worker strucvars txt-to-bin \
+            --input-type strucvar-gnomad-sv2 \
             --path-input {input.bed} \
-            --path-output-bin {output.bin}
-
+            --path-output {output.bin}
 
         varfish-db-downloader tpl \
             --template rules/output/worker/bgdb.spec.yaml \
@@ -95,6 +125,37 @@ rule output_worker_bgdb_gnomad:
         """
 
 
+rule output_worker_bgdb_gnomad_genomes_sv_grch38:
+    input:
+        bed=f"output/full/tracks/track-strucvars-gnomad-sv-grch38-{{version}}+{DV.tracks}/gnomad-sv.bed.gz",
+    output:
+        bin=f"output/full/worker/bgdb-gnomad-genomes-sv-grch38-{{version}}+{PV.worker}/bgdb-gnomad-genomes-sv-grch38.bin",
+        spec=f"output/full/worker/bgdb-gnomad-genomes-sv-grch38-{{version}}+{PV.worker}/bgdb-gnomad-genomes-sv-grch38.spec.yaml",
+    shell:
+        r"""
+        varfish-server-worker strucvars txt-to-bin \
+            --input-type strucvar-gnomad-sv4 \
+            --path-input {input.bed} \
+            --path-output {output.bin}
+
+        varfish-db-downloader tpl \
+            --template rules/output/worker/bgdb.spec.yaml \
+            \
+            --value db_name=gnomad \
+            --value title="gnomAD-SVs" \
+            --value creator="gnomAD Consortium" \
+            --value source="https://gnomad.broadinstitute.org/downloads#v4-structural-variants" \
+            \
+            --value version={wildcards.version}+{PV.worker} \
+            --value today={TODAY} \
+            --value genome_release=grch38 \
+            \
+            --value v_worker={PV.worker} \
+            --value v_downloader={PV.downloader} \
+        > {output.spec}
+        """
+
+
 rule output_worker_bgdb_dbvar:
     input:
         bed=f"output/full/tracks/track-strucvars-dbvar-{{genome_release}}-{{version}}+{DV.tracks}/dbvar.bed.gz",
@@ -103,10 +164,10 @@ rule output_worker_bgdb_dbvar:
         spec=f"output/full/worker/bgdb-dbvar-{{genome_release}}-{{version}}+{PV.worker}/bgdb-dbvar.spec.yaml",
     shell:
         r"""
-        varfish-server-worker db to-bin \
+        varfish-server-worker strucvars txt-to-bin \
             --input-type strucvar-db-var \
             --path-input {input.bed} \
-            --path-output-bin {output.bin}
+            --path-output {output.bin}
 
         varfish-db-downloader tpl \
             --template rules/output/worker/bgdb.spec.yaml \
@@ -134,10 +195,10 @@ rule output_worker_bgdb_dgv:
         spec=f"output/full/worker/bgdb-dgv-{{genome_release}}-{{version}}+{PV.worker}/bgdb-dgv.spec.yaml",
     shell:
         r"""
-        varfish-server-worker db to-bin \
+        varfish-server-worker strucvars txt-to-bin \
             --input-type strucvar-dgv \
             --path-input {input.bed} \
-            --path-output-bin {output.bin}
+            --path-output {output.bin}
 
         varfish-db-downloader tpl \
             --template rules/output/worker/bgdb.spec.yaml \
@@ -165,10 +226,10 @@ rule output_worker_bgdb_dgv_gs:
         spec=f"output/full/worker/bgdb-dgv-gs-{{genome_release}}-{{version}}+{PV.worker}/bgdb-dgv-gs.spec.yaml",
     shell:
         r"""
-        varfish-server-worker db to-bin \
+        varfish-server-worker strucvars txt-to-bin \
             --input-type strucvar-dgv-gs \
             --path-input {input.bed} \
-            --path-output-bin {output.bin}
+            --path-output {output.bin}
 
         varfish-db-downloader tpl \
             --template rules/output/worker/bgdb.spec.yaml \
diff --git a/rules/output/worker/clinvar.smk b/rules/output/worker/clinvar.smk
index 3230ab5..3891589 100644
--- a/rules/output/worker/clinvar.smk
+++ b/rules/output/worker/clinvar.smk
@@ -3,11 +3,13 @@
 
 def input_annos_strucvar_clinvar_convert(wildcards):
     """Return input files for ``rule annos_strucvar_clinvar_convert``."""
-    clinvar_version = wildcards.clinvar_release.replace("-", "").split("+")[0]
+    assert DV.clinvar_release.startswith(
+        wildcards.clinvar_release
+    ), f"DV.clinvar_release={DV.clinvar_release}, wildcards.clinvar_release={wildcards.clinvar_release}"
     return {
-        "tsv": (
+        "jsonl": (
             f"work/download/annos/{wildcards.genome_release}/strucvars/"
-            f"clinvar/{clinvar_version}/clinvar_strucvar.tsv.gz"
+            f"clinvar/{DV.clinvar_release}/clinvar-variants-{wildcards.genome_release}-strucvars.jsonl.gz"
         )
     }
 
@@ -23,10 +25,10 @@ rule annos_strucvar_clinvar_convert:
         clinvar_release=RE_VERSION,
     shell:
         r"""
-        varfish-server-worker db to-bin \
+        varfish-server-worker strucvars txt-to-bin \
             --input-type clinvar-sv \
-            --path-input {input.tsv} \
-            --path-output-bin {output.bin}
+            --path-input {input.jsonl} \
+            --path-output {output.bin}
 
         varfish-db-downloader tpl \
             --template rules/output/worker/clinvar_strucvars.spec.yaml \
diff --git a/rules/output/worker/genes_regions.smk b/rules/output/worker/genes_regions.smk
deleted file mode 100644
index c7cd499..0000000
--- a/rules/output/worker/genes_regions.smk
+++ /dev/null
@@ -1,35 +0,0 @@
-## Convert gene regions to binary for worker.
-
-
-def input_genes_regions_worker_convert(wildcards):
-    """Input function for rule genes_regions_worker_convert."""
-    return {
-        "bed": f"work/annos/{wildcards.genome_release}/features/{wildcards.source}/{wildcards.version}/{wildcards.source}_genes.bed.gz",
-    }
-
-
-rule genes_regions_worker_convert:
-    input:
-        unpack(input_genes_regions_worker_convert),
-    output:
-        bin=f"output/full/worker/genes-regions-{{genome_release}}-{{version}}+{PV.worker}/{{source}}_genes.bin",
-        spec_yaml=f"output/full/worker/genes-regions-{{genome_release}}-{{version}}+{PV.worker}/{{source}}_genes.spec.yaml",
-    shell:
-        r"""
-        varfish-server-worker \
-            db to-bin \
-            --input-type gene-region \
-            --path-input {input.bed} \
-            --path-output-bin {output.bin}
-
-        varfish-db-downloader tpl \
-            --template rules/output/worker/{wildcards.source}_genes.spec.yaml \
-            --value today={TODAY} \
-            --value genome_release={wildcards.genome_release} \
-            \
-            --value version={wildcards.version} \
-            \
-            --value v_worker={PV.worker} \
-            --value v_downloader={PV.downloader} \
-        > {output.spec_yaml}
-        """
diff --git a/rules/output/worker/hgnc.smk b/rules/output/worker/hgnc.smk
index 1babd54..3fd83b9 100644
--- a/rules/output/worker/hgnc.smk
+++ b/rules/output/worker/hgnc.smk
@@ -14,10 +14,10 @@ rule output_hgnc_xlink_binary:
             exit 1
         fi
 
-        varfish-server-worker db to-bin \
+        varfish-server-worker strucvars txt-to-bin \
             --input-type xlink \
             --path-input {input.tsv} \
-            --path-output-bin {output.bin}
+            --path-output {output.bin}
 
         varfish-db-downloader tpl \
             --template rules/output/worker/hgnc_xlink.spec.yaml \
diff --git a/rules/output/worker/masked.smk b/rules/output/worker/masked.smk
index 4e46f74..263088d 100644
--- a/rules/output/worker/masked.smk
+++ b/rules/output/worker/masked.smk
@@ -12,10 +12,10 @@ rule output_masked_repeat:
         version=RE_VERSION,
     shell:
         r"""
-        varfish-server-worker db to-bin \
+        varfish-server-worker strucvars txt-to-bin \
             --input-type masked-region \
             --path-input {input} \
-            --path-output-bin {output.bin}
+            --path-output {output.bin}
 
         varfish-db-downloader tpl \
             --template rules/output/worker/masked_repeat.spec.yaml \
@@ -41,10 +41,10 @@ rule output_masked_segdup:
         version=RE_VERSION,
     shell:
         r"""
-        varfish-server-worker db to-bin \
+        varfish-server-worker strucvars txt-to-bin \
             --input-type masked-region \
             --path-input {input} \
-            --path-output-bin {output.bin}
+            --path-output {output.bin}
 
         varfish-db-downloader tpl \
             --template rules/output/worker/masked_segdup.spec.yaml \
diff --git a/rules/work/annos/strucvars/clinvar.smk b/rules/work/annos/strucvars/clinvar.smk
index c852b43..2b148a8 100644
--- a/rules/work/annos/strucvars/clinvar.smk
+++ b/rules/work/annos/strucvars/clinvar.smk
@@ -3,11 +3,10 @@
 
 rule annos_strucvars_clinvar_download:  # -- download/extract ClinVar files
     output:
-        tar=f"work/download/annos/{{genome_release}}/strucvars/clinvar/{{clinvar_version}}/clinvar-strucvar-{{genome_release}}-{DV.clinvar_release}.tar.gz",
-        tsv="work/download/annos/{genome_release}/strucvars/clinvar/{clinvar_version}/clinvar_strucvar.tsv.gz",
+        jsonl="work/download/annos/{genome_release}/strucvars/clinvar/{clinvar_version}/clinvar-variants-{genome_release}-strucvars.jsonl.gz",
     wildcard_constraints:
         genome_release=RE_GENOME,
-        clinvar_version=RE_VERSION,
+        clinvar_version=RE_VERSION_MULTI,
     shell:
         r"""
         clinvar_version=$(echo "{wildcards.clinvar_version}" | sed -e 's/-//g' | cut -d '+' -f 1)
@@ -16,27 +15,9 @@ rule annos_strucvars_clinvar_download:  # -- download/extract ClinVar files
         trap "rm -rf $TMPDIR" ERR EXIT
 
         wget --no-check-certificate \
-            -O {output.tar} \
-            https://github.com/bihealth/annonars-data-clinvar/releases/download/clinvar-weekly-$clinvar_version/$(basename {output.tar})
+            -O /tmp/clinvar-data-extract-vars-{wildcards.clinvar_version}.tar.gz \
+            https://github.com/varfish-org/clinvar-data-jsonl/releases/download/clinvar-weekly-$clinvar_version/clinvar-data-extract-vars-{wildcards.clinvar_version}.tar.gz
 
-        if [[ {wildcards.genome_release} == grch37 ]]; then
-            release=GRCh37
-        else
-            release=GRCh38
-        fi
-
-        tar -C $TMPDIR -xvf $(readlink -f {output.tar})
-        cut -f 2- $TMPDIR/clinvar-strucvar-{wildcards.genome_release}*/output.tsv \
-        | awk \
-            -F $'\t' \
-            -v release=$release \
-            -v clinvar_version={wildcards.clinvar_version} \
-            \
-            '
-            BEGIN {{ OFS=FS }}
-            (NR == 1) {{ print "#" $0; }}
-            (NR > 1) {{ $8 = clinvar_version; print $0; }}
-            ' \
-        | gzip -c \
-        > {output.tsv}
+        tar -C $TMPDIR -xvf /tmp/clinvar-data-extract-vars-{wildcards.clinvar_version}.tar.gz
+        cp $TMPDIR/clinvar-data-extract-vars-{wildcards.clinvar_version}/clinvar-variants-{wildcards.genome_release}-strucvars.jsonl.gz {output.jsonl}
         """
diff --git a/rules/work/annos/strucvars/gnomad.smk b/rules/work/annos/strucvars/gnomad.smk
index 33467f7..6e824fd 100644
--- a/rules/work/annos/strucvars/gnomad.smk
+++ b/rules/work/annos/strucvars/gnomad.smk
@@ -1,7 +1,7 @@
 ## Rules related to gnomAD-SV.
 
 
-rule annos_strucvars_gnomad_grch37_download:  # -- download gnomAD-SV files
+rule annos_strucvars_gnomad_sv2_grch37_download:  # -- download gnomAD-SV v2 files
     output:
         vcf="work/download/annos/grch37/strucvars/gnomad/2.1.1/gnomad_v2.1_sv.{token}.vcf.gz",
     shell:
@@ -12,7 +12,7 @@ rule annos_strucvars_gnomad_grch37_download:  # -- download gnomAD-SV files
         """
 
 
-rule annos_strucvars_gnomad_grch37_process:  # -- process gnomAD-SV files
+rule annos_strucvars_gnomad_sv2_grch37_process:  # -- process gnomAD-SV v2 files
     input:
         vcf="work/download/annos/grch37/strucvars/gnomad/2.1.1/gnomad_v2.1_sv.sites.vcf.gz",
     output:
diff --git a/rules/work/annos/strucvars/gnomad_sv4.smk b/rules/work/annos/strucvars/gnomad_sv4.smk
index bf7ef03..b47d9b5 100644
--- a/rules/work/annos/strucvars/gnomad_sv4.smk
+++ b/rules/work/annos/strucvars/gnomad_sv4.smk
@@ -12,6 +12,64 @@ rule annos_strucvars_gnomad_sv_4_grch38_download:  # -- download gnomAD-SV 4.0 f
         """
 
 
+rule annos_strucvars_gnomad_sv_4_grch38_process:  # -- process gnomAD-SV v4 files
+    input:
+        vcf=[
+            f"work/download/annos/grch38/strucvars/gnomad_sv/{{version}}/gnomad.v{{version}}.sv.chr{chrom}.vcf.gz"
+            for chrom in list(range(1, 23)) + ["X", "Y"]
+        ],
+    output:
+        bed=f"output/full/tracks/track-strucvars-gnomad-sv-grch38-{{version}}+{DV.tracks}/gnomad-sv.bed.gz",
+        bed_md5=f"output/full/tracks/track-strucvars-gnomad-sv-grch38-{{version}}+{DV.tracks}/gnomad-sv.bed.gz.md5",
+        bed_tbi=f"output/full/tracks/track-strucvars-gnomad-sv-grch38-{{version}}+{DV.tracks}/gnomad-sv.bed.gz.tbi",
+        bed_tbi_md5=f"output/full/tracks/track-strucvars-gnomad-sv-grch38-{{version}}+{DV.tracks}/gnomad-sv.bed.gz.tbi.md5",
+    shell:
+        r"""
+        export TMPDIR=$(mktemp -d)
+        trap "rm -rf $TMPDIR" ERR EXIT
+
+        echo -e "#chromosome\tbegin\tend\tsv_type\tmale_n_homref\tmale_n_het\tmale_n_homalt\tmale_n_hemiref\tmale_n_hemialt\tfemale_n_homref\tfemale_n_het\tfemale_n_homalt\tcnv_n_total\tcnv_n_var" \
+        > $TMPDIR/tmp.bed
+
+        for vcf in {input.vcf}; do
+            bcftools query \
+                -f "%CHROM\t%POS0\t%INFO/END\t%INFO/SVTYPE\t%INFO/MALE_N_HOMREF\t%INFO/MALE_N_HET\t%INFO/MALE_N_HOMALT\t%INFO/MALE_N_HEMIREF\t%INFO/MALE_N_HEMIALT\t%INFO/FEMALE_N_HOMREF\t%INFO/FEMALE_N_HET\t%INFO/FEMALE_N_HOMALT\t%CN_NUMBER\t%CN_COUNT\n" \
+                $vcf \
+            | awk -v OFS='\t' '{{
+                if ($5 == ".") {{ $5 = 0; }}
+                if ($6 == ".") {{ $6 = 0; }}
+                if ($7 == ".") {{ $7 = 0; }}
+                if ($8 == ".") {{ $8 = 0; }}
+                if ($9 == ".") {{ $9 = 0; }}
+                if ($10 == ".") {{ $10 = 0; }}
+                if ($11 == ".") {{ $11 = 0; }}
+                if ($12 == ".") {{ $12 = 0; }}
+                if ($13 == ".") {{ $13 = 0; }}
+                if ($14 == ".") {{
+                    $14 = 0
+                }} else {{
+                    sum = 0
+                    split($14, a, ",")
+                    for (x in a) {{
+                        sum += x
+                    }}
+                    $14 = sum
+                }}
+                print $0
+            }}' \
+            | sed -e 's/CPX/BND/g' -e 's/CTX/BND/g' \
+            >> $TMPDIR/tmp.bed
+        done
+
+        bgzip -c $TMPDIR/tmp.bed >{output.bed}
+
+        tabix -p bed -S 1 -f {output.bed}
+
+        md5sum {output.bed} >{output.bed_md5}
+        md5sum {output.bed_tbi} >{output.bed_tbi_md5}
+        """
+
+
 rule annos_strucvars_gnomad_cnv_4_grch38_download:  # -- download gnomAD-CNV 4.0 files
     output:
         vcf="work/download/annos/grch38/strucvars/gnomad_cnv/4.0/gnomad.v4.0.cnv.{token}.vcf.gz",
@@ -21,3 +79,35 @@ rule annos_strucvars_gnomad_cnv_4_grch38_download:  # -- download gnomAD-CNV 4.0
             -O {output.vcf} \
             https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/exome_cnv/gnomad.v4.0.cnv.{wildcards.token}.vcf.gz
         """
+
+
+rule annos_strucvars_gnomad_cnv_4_grch38_process:  # -- process gnomAD-CNV 4.0 files
+    input:
+        vcf="work/download/annos/grch38/strucvars/gnomad_cnv/{version}/gnomad.v{version}.cnv.all.vcf.gz",
+    output:
+        bed=f"output/full/tracks/track-strucvars-gnomad-cnv-grch38-{{version}}+{DV.tracks}/gnomad-cnv.bed.gz",
+        bed_md5=f"output/full/tracks/track-strucvars-gnomad-cnv-grch38-{{version}}+{DV.tracks}/gnomad-cnv.bed.gz.md5",
+        bed_tbi=f"output/full/tracks/track-strucvars-gnomad-cnv-grch38-{{version}}+{DV.tracks}/gnomad-cnv.bed.gz.tbi",
+        bed_tbi_md5=f"output/full/tracks/track-strucvars-gnomad-cnv-grch38-{{version}}+{DV.tracks}/gnomad-cnv.bed.gz.tbi.md5",
+    shell:
+        r"""
+        set -euo pipefail
+
+        export TMPDIR=$(mktemp -d)
+        trap "rm -rf $TMPDIR" ERR EXIT
+
+        echo -e "#chromosome\tbegin\tend\tsv_type\tn_total\tn_var" \
+        > $TMPDIR/tmp.bed
+
+        bcftools query \
+            -f "%CHROM\t%POS0\t%INFO/END\t%INFO/SVTYPE\t%INFO/SN\t%INFO/SC\n" \
+            {input.vcf} \
+        >> $TMPDIR/tmp.bed
+
+        bgzip -c $TMPDIR/tmp.bed >{output.bed}
+
+        tabix -p bed -S 1 -f {output.bed}
+
+        md5sum {output.bed} >{output.bed_md5}
+        md5sum {output.bed_tbi} >{output.bed_tbi_md5}
+        """
diff --git a/varfish_db_downloader/versions.py b/varfish_db_downloader/versions.py
index ababfc2..361723c 100644
--- a/varfish_db_downloader/versions.py
+++ b/varfish_db_downloader/versions.py
@@ -11,7 +11,7 @@
 #: Allow to disable the today check.
 FORCE_TODAY = os.environ.get("FORCE_TODAY", "false").lower() == "true"
 #: The ClinVar release to use (includes annonars version used for building).
-CLINVAR_RELEASE = os.environ.get("CLINVAR_RELEASE", "2023-0625+0.6.3")
+CLINVAR_RELEASE = os.environ.get("CLINVAR_RELEASE", "20240612+0.17.0")
 #: The ClinVar version to use (part of the tag and release name).
 CLINVAR_VERSION = CLINVAR_RELEASE.replace("-", "").split("+")[0]