diff --git a/download_urls.yml b/download_urls.yml
index 0f86ab9..ae1e4b7 100644
--- a/download_urls.yml
+++ b/download_urls.yml
@@ -92,111 +92,23 @@
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/papers/2019-sv/gnomad_v2.1_sv.sites.vcf.gz
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/papers/2019-sv/gnomad_v2.1_sv.controls_only.sites.vcf.gz
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/papers/2019-sv/gnomad_v2.1_sv.nonneuro.sites.vcf.gz
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/exome_cnv/gnomad.v4.0.cnv.all.vcf.gz
+- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.1/exome_cnv/gnomad.v4.1.cnv.all.vcf.gz
   excerpt_strategy:
     strategy: gz-head
     count: 160
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/exome_cnv/gnomad.v4.0.cnv.non_neuro.vcf.gz
+- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.1/exome_cnv/gnomad.v4.1.cnv.non_neuro.vcf.gz
   excerpt_strategy:
     strategy: gz-head
     count: 160
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/exome_cnv/gnomad.v4.0.cnv.non_neuro_controls.vcf.gz
+- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.1/exome_cnv/gnomad.v4.1.cnv.non_neuro_controls.vcf.gz
   excerpt_strategy:
     strategy: gz-head
     count: 160
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr1.vcf.gz
+- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.1/genome_sv/gnomad.v4.1.sv.sites.vcf.gz
   excerpt_strategy:
     strategy: vcf-head
     count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr2.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr3.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr4.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr5.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr6.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr7.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr8.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr9.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr10.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr11.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr12.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr13.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr14.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr15.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr16.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr17.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr18.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr19.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr20.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr21.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr22.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chrX.vcf.gz
-  excerpt_strategy:
-    strategy: vcf-head
-    count: 1800
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chrY.vcf.gz
+- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.1/genome_sv/gnomad.v4.1.sv.non_neuro_controls.sites.vcf.gz
   excerpt_strategy:
     strategy: vcf-head
     count: 1800
@@ -346,7 +258,7 @@
     count: null
 
 - url: https://storage.googleapis.com/gcp-public-data--gnomad/release/2.1.1/constraint/gnomad.v2.1.1.lof_metrics.by_gene.txt.bgz
-- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/v4.0/constraint/gnomad.v4.0.constraint_metrics.tsv
+- url: https://storage.googleapis.com/gcp-public-data--gnomad/release/4.1/constraint/gnomad.v4.1.constraint_metrics.tsv
 - url: https://ftp.ncbi.nih.gov/gene/DATA/mim2gene_medgen
 
 - comment: We replace the linux64.gene2.xml binary with a wrapper to zcat...
@@ -392,105 +304,105 @@
 - url: ftp://ftp.broadinstitute.org/pub/ExAC_release/release0.3.1/cnv/exac-final.autosome-1pct-sq60-qc-prot-coding.cnv.bed
 - url: https://ftp-trace.ncbi.nih.gov/1000genomes/ftp/phase3/integrated_sv_map/ALL.wgs.integrated_sv_map_v2.20130502.svs.genotypes.vcf.gz
 
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr1.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr2.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr3.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr4.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr5.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr6.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr7.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr8.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr9.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr10.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr11.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr12.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr13.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr14.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr15.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr16.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr17.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr18.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr19.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr20.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr21.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr22.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chrX.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chrY.vcf.bgz
-
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr1.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr2.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr3.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr4.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr5.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr6.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr7.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr8.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr9.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr10.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr11.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr12.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr13.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr14.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr15.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr16.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr17.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr18.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr19.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr20.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr21.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chr22.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chrX.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/exomes/gnomad.exomes.v4.0.sites.chrY.vcf.bgz.tbi
-
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr1.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr2.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr3.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr4.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr5.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr6.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr7.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr8.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr9.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr10.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr11.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr12.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr13.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr14.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr15.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr16.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr17.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr18.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr19.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr20.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr21.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr22.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chrX.vcf.bgz
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chrY.vcf.bgz
-
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr1.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr2.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr3.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr4.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr5.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr6.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr7.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr8.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr9.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr10.vcf.bgz.tbi
-- url: https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.0/vcf/genomes/gnomad.genomes.v4.0.sites.chr11.vcf.bgz.tbi
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new file mode 100644
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+++ b/excerpt-data/fee2ba2791beadbf/gnomad.genomes.v4.1.sites.chr16.vcf.bgz.tbi
@@ -0,0 +1,3 @@
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diff --git a/excerpt-data/fee2ba2791beadbf/url.txt b/excerpt-data/fee2ba2791beadbf/url.txt
new file mode 100644
index 0000000..3f51248
--- /dev/null
+++ b/excerpt-data/fee2ba2791beadbf/url.txt
@@ -0,0 +1,3 @@
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diff --git a/rules/output/annonars/gnomad_sv.smk b/rules/output/annonars/gnomad_sv.smk
index 0994cea..7f52a9f 100644
--- a/rules/output/annonars/gnomad_sv.smk
+++ b/rules/output/annonars/gnomad_sv.smk
@@ -88,7 +88,7 @@ rule output_annonars_gnomad_sv_grch37_gnomad_sv2:  # -- build gnomAD-SV RocksDB
 rule output_annonars_gnomad_sv_grch38_gnomad_cnv4:  # -- build gnomAD-SV RocksDB with annonars; gnomAD-CNV v4 variant
     input:
         vcf=[
-            f"work/download/annos/grch38/strucvars/gnomad_cnv/4.0/gnomad.v4.0.cnv.{token}.vcf.gz"
+            f"work/download/annos/grch38/strucvars/gnomad_cnv/{{v_gnomad}}/gnomad.v{{v_gnomad}}.cnv.{token}.vcf.gz"
             for token in ("all", "non_neuro", "non_neuro_controls")
         ],
     output:
@@ -128,10 +128,7 @@ rule output_annonars_gnomad_sv_grch38_gnomad_cnv4:  # -- build gnomAD-SV RocksDB
 
 rule output_annonars_gnomad_sv_grch38_gnomad_sv4:  # -- build gnomAD-SV RocksDB with annonars; gnomAD-SV v4 variant
     input:
-        vcf=[
-            f"work/download/annos/grch38/strucvars/gnomad_sv/4.0/gnomad.v4.0.sv.chr{chrom}.vcf.gz"
-            for chrom in list(range(1, 23)) + ["X", "Y"]
-        ],
+        vcf="work/download/annos/grch38/strucvars/gnomad_sv/{v_gnomad}/gnomad.v{v_gnomad}.sv.sites.vcf.gz",
     output:
         rocksdb_identity=(
             "output/full/annonars/gnomad-sv-genomes-grch38-{v_gnomad}+{v_annonars}/rocksdb/IDENTITY",
@@ -152,7 +149,7 @@ rule output_annonars_gnomad_sv_grch38_gnomad_sv4:  # -- build gnomAD-SV RocksDB
         annonars gnomad-sv import \
             --gnomad-kind genomes \
             --genome-release grch38 \
-            $(for vcf in {input.vcf}; do echo --path-in-vcf $vcf; done) \
+            --path-in-vcf {input.vcf} \
             --path-out-rocksdb $(dirname {output.rocksdb_identity}) \
             --gnomad-version {wildcards.v_gnomad}
 
diff --git a/rules/work/annos/strucvars/gnomad_sv4.smk b/rules/work/annos/strucvars/gnomad_sv4.smk
index b47d9b5..90d2008 100644
--- a/rules/work/annos/strucvars/gnomad_sv4.smk
+++ b/rules/work/annos/strucvars/gnomad_sv4.smk
@@ -1,28 +1,29 @@
 ## Rules related to gnomAD-SV and gnomAD-CNV v4.
 
 
-rule annos_strucvars_gnomad_sv_4_grch38_download:  # -- download gnomAD-SV 4.0 files
+rule annos_strucvars_gnomad_sv_4_grch38_download:  # -- download gnomAD-SV >=4.1 files
     output:
-        vcf="work/download/annos/grch38/strucvars/gnomad_sv/4.0/gnomad.v4.0.sv.chr{chrom}.vcf.gz",
+        vcf="work/download/annos/grch38/strucvars/gnomad_sv/{v_gnomad}/gnomad.v{v_gnomad}.sv.{token}.vcf.gz",
+    wildcard_constraints:
+        v_gnomad=RE_VERSION,
     shell:
         r"""
         wget --no-check-certificate \
             -O {output.vcf} \
-            https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/genome_sv/gnomad.v4.0.sv.chr{wildcards.chrom}.vcf.gz
+            https://storage.googleapis.com/gcp-public-data--gnomad/release/{wildcards.v_gnomad}/genome_sv/gnomad.v{wildcards.v_gnomad}.sv.{wildcards.token}.vcf.gz
         """
 
 
 rule annos_strucvars_gnomad_sv_4_grch38_process:  # -- process gnomAD-SV v4 files
     input:
-        vcf=[
-            f"work/download/annos/grch38/strucvars/gnomad_sv/{{version}}/gnomad.v{{version}}.sv.chr{chrom}.vcf.gz"
-            for chrom in list(range(1, 23)) + ["X", "Y"]
-        ],
+        vcf="work/download/annos/grch38/strucvars/gnomad_sv/{version}/gnomad.v{version}.sv.sites.vcf.gz",
     output:
         bed=f"output/full/tracks/track-strucvars-gnomad-sv-grch38-{{version}}+{DV.tracks}/gnomad-sv.bed.gz",
         bed_md5=f"output/full/tracks/track-strucvars-gnomad-sv-grch38-{{version}}+{DV.tracks}/gnomad-sv.bed.gz.md5",
         bed_tbi=f"output/full/tracks/track-strucvars-gnomad-sv-grch38-{{version}}+{DV.tracks}/gnomad-sv.bed.gz.tbi",
         bed_tbi_md5=f"output/full/tracks/track-strucvars-gnomad-sv-grch38-{{version}}+{DV.tracks}/gnomad-sv.bed.gz.tbi.md5",
+    wildcard_constraints:
+        version=RE_VERSION,
     shell:
         r"""
         export TMPDIR=$(mktemp -d)
@@ -31,35 +32,33 @@ rule annos_strucvars_gnomad_sv_4_grch38_process:  # -- process gnomAD-SV v4 file
         echo -e "#chromosome\tbegin\tend\tsv_type\tmale_n_homref\tmale_n_het\tmale_n_homalt\tmale_n_hemiref\tmale_n_hemialt\tfemale_n_homref\tfemale_n_het\tfemale_n_homalt\tcnv_n_total\tcnv_n_var" \
         > $TMPDIR/tmp.bed
 
-        for vcf in {input.vcf}; do
-            bcftools query \
-                -f "%CHROM\t%POS0\t%INFO/END\t%INFO/SVTYPE\t%INFO/MALE_N_HOMREF\t%INFO/MALE_N_HET\t%INFO/MALE_N_HOMALT\t%INFO/MALE_N_HEMIREF\t%INFO/MALE_N_HEMIALT\t%INFO/FEMALE_N_HOMREF\t%INFO/FEMALE_N_HET\t%INFO/FEMALE_N_HOMALT\t%CN_NUMBER\t%CN_COUNT\n" \
-                $vcf \
-            | awk -v OFS='\t' '{{
-                if ($5 == ".") {{ $5 = 0; }}
-                if ($6 == ".") {{ $6 = 0; }}
-                if ($7 == ".") {{ $7 = 0; }}
-                if ($8 == ".") {{ $8 = 0; }}
-                if ($9 == ".") {{ $9 = 0; }}
-                if ($10 == ".") {{ $10 = 0; }}
-                if ($11 == ".") {{ $11 = 0; }}
-                if ($12 == ".") {{ $12 = 0; }}
-                if ($13 == ".") {{ $13 = 0; }}
-                if ($14 == ".") {{
-                    $14 = 0
-                }} else {{
-                    sum = 0
-                    split($14, a, ",")
-                    for (x in a) {{
-                        sum += x
-                    }}
-                    $14 = sum
+        bcftools query \
+            -f "%CHROM\t%POS0\t%INFO/END\t%INFO/SVTYPE\t%INFO/N_HOMREF_XY\t%INFO/N_HET_XY\t%INFO/N_HOMALT_XY\t%INFO/N_HEMIREF_XY\t%INFO/N_HEMIALT_XY\t%INFO/N_HOMREF_XY\t%INFO/N_HET_XY\t%INFO/N_HOMALT_XY\t%CN_NUMBER\t%CN_COUNT\n" \
+            {input.vcf} \
+        | awk -v OFS='\t' '{{
+            if ($5 == ".") {{ $5 = 0; }}
+            if ($6 == ".") {{ $6 = 0; }}
+            if ($7 == ".") {{ $7 = 0; }}
+            if ($8 == ".") {{ $8 = 0; }}
+            if ($9 == ".") {{ $9 = 0; }}
+            if ($10 == ".") {{ $10 = 0; }}
+            if ($11 == ".") {{ $11 = 0; }}
+            if ($12 == ".") {{ $12 = 0; }}
+            if ($13 == ".") {{ $13 = 0; }}
+            if ($14 == ".") {{
+                $14 = 0
+            }} else {{
+                sum = 0
+                split($14, a, ",")
+                for (x in a) {{
+                    sum += x
                 }}
-                print $0
-            }}' \
-            | sed -e 's/CPX/BND/g' -e 's/CTX/BND/g' \
-            >> $TMPDIR/tmp.bed
-        done
+                $14 = sum
+            }}
+            print $0
+        }}' \
+        | sed -e 's/CPX/BND/g' -e 's/CTX/BND/g' \
+        >> $TMPDIR/tmp.bed
 
         bgzip -c $TMPDIR/tmp.bed >{output.bed}
 
@@ -70,18 +69,20 @@ rule annos_strucvars_gnomad_sv_4_grch38_process:  # -- process gnomAD-SV v4 file
         """
 
 
-rule annos_strucvars_gnomad_cnv_4_grch38_download:  # -- download gnomAD-CNV 4.0 files
+rule annos_strucvars_gnomad_cnv_4_grch38_download:  # -- download gnomAD-CNV >=4.1 files
     output:
-        vcf="work/download/annos/grch38/strucvars/gnomad_cnv/4.0/gnomad.v4.0.cnv.{token}.vcf.gz",
+        vcf="work/download/annos/grch38/strucvars/gnomad_cnv/{v_gnomad}/gnomad.v{v_gnomad}.cnv.{token}.vcf.gz",
+    wildcard_constraints:
+        v_gnomad=RE_VERSION,
     shell:
         r"""
         wget --no-check-certificate \
             -O {output.vcf} \
-            https://storage.googleapis.com/gcp-public-data--gnomad/release/4.0/exome_cnv/gnomad.v4.0.cnv.{wildcards.token}.vcf.gz
+            https://storage.googleapis.com/gcp-public-data--gnomad/release/{wildcards.v_gnomad}/exome_cnv/gnomad.v{wildcards.v_gnomad}.cnv.{wildcards.token}.vcf.gz
         """
 
 
-rule annos_strucvars_gnomad_cnv_4_grch38_process:  # -- process gnomAD-CNV 4.0 files
+rule annos_strucvars_gnomad_cnv_4_grch38_process:  # -- process gnomAD-CNV >=4.1 files
     input:
         vcf="work/download/annos/grch38/strucvars/gnomad_cnv/{version}/gnomad.v{version}.cnv.all.vcf.gz",
     output:
@@ -89,6 +90,8 @@ rule annos_strucvars_gnomad_cnv_4_grch38_process:  # -- process gnomAD-CNV 4.0 f
         bed_md5=f"output/full/tracks/track-strucvars-gnomad-cnv-grch38-{{version}}+{DV.tracks}/gnomad-cnv.bed.gz.md5",
         bed_tbi=f"output/full/tracks/track-strucvars-gnomad-cnv-grch38-{{version}}+{DV.tracks}/gnomad-cnv.bed.gz.tbi",
         bed_tbi_md5=f"output/full/tracks/track-strucvars-gnomad-cnv-grch38-{{version}}+{DV.tracks}/gnomad-cnv.bed.gz.tbi.md5",
+    wildcard_constraints:
+        version=RE_VERSION,
     shell:
         r"""
         set -euo pipefail
diff --git a/rules/work/genes/gnomad.smk b/rules/work/genes/gnomad.smk
index 76e7813..3e55eb3 100644
--- a/rules/work/genes/gnomad.smk
+++ b/rules/work/genes/gnomad.smk
@@ -85,21 +85,21 @@ rule genes_gnomad_convert_v2_1_1:  # -- create gnomAD gene constraints TSV (v2.1
         run_genes_gnomad_constraints_v2_1_1_to_tsv(input, output, wildcards)
 
 
-rule genes_gnomad_download_v4_0:  # -- download gnomAD gene constraints v4.0
+rule genes_gnomad_download_v4:  # -- download gnomAD gene constraints v4.1
     output:
-        tsv="work/download/genes/gnomad/4.0/gnomad.v4.0.constraint_metrics.tsv",
-        tsv_md5="work/download/genes/gnomad/4.0/gnomad.v4.0.constraint_metrics.tsv.md5",
+        tsv="work/download/genes/gnomad/{version}/gnomad.v{version}.constraint_metrics.tsv",
+        tsv_md5="work/download/genes/gnomad/{version}/gnomad.v{version}.constraint_metrics.tsv.md5",
     shell:
         r"""
         wget --no-check-certificate \
             -O {output.tsv} \
-            https://storage.googleapis.com/gcp-public-data--gnomad/release/v4.0/constraint/gnomad.v4.0.constraint_metrics.tsv
+            https://storage.googleapis.com/gcp-public-data--gnomad/release/{wildcards.version}/constraint/gnomad.v{wildcards.version}.constraint_metrics.tsv
 
         md5sum {output.tsv} >{output.tsv_md5}
         """
 
 
-def run_genes_gnomad_constraints_v4_0_to_tsv(input, output, wildcards):
+def run_genes_gnomad_constraints_v4_to_tsv(input, output, wildcards):
     """Extra function because of snakefmt issues.
 
     Note that the names in the output file are taken from the v2.1.1 file.
@@ -180,12 +180,12 @@ def run_genes_gnomad_constraints_v4_0_to_tsv(input, output, wildcards):
     )
 
 
-rule genes_gnomad_convert_v4_0:  # -- create gnomAD gene constraints TSV (v4.0)
+rule genes_gnomad_convert_v4:  # -- create gnomAD gene constraints TSV (v4.x)
     input:
-        tsv="work/download/genes/gnomad/4.0/gnomad.v4.0.constraint_metrics.tsv",
+        tsv="work/download/genes/gnomad/{v_gnomad_constraints}/gnomad.v{v_gnomad_constraints}.constraint_metrics.tsv",
         xlink_ensembl=f"work/genes/ensembl/{DV.ensembl}/ensembl_xlink.tsv",
     output:
-        tsv="work/genes/gnomad/4.0/gnomad_constraints.tsv",
-        tsv_md5="work/genes/gnomad/4.0/gnomad_constraints.tsv.md5",
+        tsv="work/genes/gnomad/{v_gnomad_constraints}/gnomad_constraints.tsv",
+        tsv_md5="work/genes/gnomad/{v_gnomad_constraints}/gnomad_constraints.tsv.md5",
     run:
-        run_genes_gnomad_constraints_v4_0_to_tsv(input, output, wildcards)
+        run_genes_gnomad_constraints_v4_to_tsv(input, output, wildcards)
diff --git a/varfish_db_downloader/versions.py b/varfish_db_downloader/versions.py
index 361723c..f88559c 100644
--- a/varfish_db_downloader/versions.py
+++ b/varfish_db_downloader/versions.py
@@ -133,14 +133,14 @@ class DataVersions:
     dbnsfp="4.5",
     dbscsnv="1.1",
     cadd="1.6",
-    gnomad_constraints="4.0",
+    gnomad_constraints="4.1",
     gnomad_mtdna="3.1",
     gnomad_v2="2.1.1",
     gnomad_v3="3.1.2",
-    gnomad_v4="4.0",
+    gnomad_v4="4.1",
     gnomad_sv="2.1.1",
-    gnomad_cnv4="4.0",
-    gnomad_sv4="4.0",
+    gnomad_cnv4="4.1",
+    gnomad_sv4="4.1",
     dbvar="20231030",
     dgv="20200225",
     dgv_gs="20160515",