diff --git a/Snakefile b/Snakefile
index e088368..f1f01f0 100644
--- a/Snakefile
+++ b/Snakefile
@@ -131,6 +131,7 @@ rule all:
         f"work/annos/grch38/features/cons/{DV.ucsc_cons_38}/ucsc_conservation.tsv",
         f"work/annos/grch38/features/ensembl/{DV.ensembl_38}/ensembl_genes.bed.gz",
         f"work/annos/grch38/features/refseq/{DV.refseq_38}/refseq_genes.bed.gz",
+        # f"work/annos/grch38/features/clingen_dosage/{DV.today}/clingen_dosage_sensitivity_regions.bed.gz",
         #
         # == output directory ===================================================================
         #
@@ -161,6 +162,9 @@ rule all:
         # ----- conservation
         f"output/full/annonars/cons-grch37-{DV.ucsc_cons_37}+{PV.annonars}/rocksdb/IDENTITY",
         f"output/full/annonars/cons-grch38-{DV.ucsc_cons_38}+{PV.annonars}/rocksdb/IDENTITY",
+        # ----- features
+        f"output/full/annonars/clingen-dosage-grch37/{DV.today}/clingen_region_curation_list.bed.gz",
+        f"output/full/annonars/clingen-dosage-grch38/{DV.today}/clingen_region_curation_list.bed.gz",
         # ----- genes
         f"output/full/annonars/genes-{DV.acmg_sf}+{DV.gnomad_constraints}+{DV.dbnsfp}+{DV.hpo}+{DV.orphapacket}+{DV.today}+{PV.annonars}/rocksdb/IDENTITY",
         # -- worker data
@@ -339,6 +343,7 @@ include: "rules/work/genes/shet.smk"
 include: "rules/work/reference/human.smk"
 # Features (position and not variant specific).
 include: "rules/work/annos/features/cons.smk"
+include: "rules/work/annos/features/clingen_dosage.smk"
 include: "rules/work/annos/features/ensembl.smk"
 include: "rules/work/annos/features/refseq.smk"
 include: "rules/work/annos/features/tads.smk"
@@ -363,7 +368,7 @@ include: "rules/work/annos/strucvars/clinvar.smk"
 include: "rules/output/mehari/freqs.smk"
 # ---- viguno
 include: "rules/output/viguno/hpo.smk"
-# ------ annonars
+# ---- annonars
 include: "rules/output/annonars/cadd.smk"
 include: "rules/output/annonars/cons.smk"
 include: "rules/output/annonars/dbnsfp.smk"
@@ -374,6 +379,8 @@ include: "rules/output/annonars/gnomad_genomes.smk"
 include: "rules/output/annonars/gnomad_mtdna.smk"
 include: "rules/output/annonars/helix.smk"
 include: "rules/output/annonars/genes.smk"
+# ------ features
+include: "rules/output/annonars/clingen_dosage.smk"
 # ---- worker
 include: "rules/output/worker/patho_mms.smk"
 include: "rules/output/worker/clinvar.smk"
diff --git a/download_urls.yml b/download_urls.yml
index 541e3cc..a200799 100644
--- a/download_urls.yml
+++ b/download_urls.yml
@@ -1,3 +1,6 @@
+- url: ftp://ftp.clinicalgenome.org/ClinGen_region_curation_list_GRCh37.tsv
+- url: ftp://ftp.clinicalgenome.org/ClinGen_region_curation_list_GRCh38.tsv
+
 - url: https://storage.googleapis.com/gtex_analysis_v8/annotations/GTEx_Analysis_v8_Annotations_SampleAttributesDS.txt
   excerpt_strategy:
     strategy: no-excerpt
diff --git a/excerpt-data/796c631dc892eda6/ClinGen_region_curation_list_GRCh38.tsv b/excerpt-data/796c631dc892eda6/ClinGen_region_curation_list_GRCh38.tsv
new file mode 100644
index 0000000..f24e604
--- /dev/null
+++ b/excerpt-data/796c631dc892eda6/ClinGen_region_curation_list_GRCh38.tsv
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:f31a9b57fa53dc4158bd91a5c998cbaed38fef695d5f146d73bc9b5ca2787412
+size 18834
diff --git a/excerpt-data/796c631dc892eda6/url.txt b/excerpt-data/796c631dc892eda6/url.txt
new file mode 100644
index 0000000..07f853b
--- /dev/null
+++ b/excerpt-data/796c631dc892eda6/url.txt
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:74891f7b36b2b5162805ce07c2e356cbe4a8f3339c60a53fe3b7625a13ffbae5
+size 69
diff --git a/excerpt-data/e424cce724cdc500/ClinGen_region_curation_list_GRCh37.tsv b/excerpt-data/e424cce724cdc500/ClinGen_region_curation_list_GRCh37.tsv
new file mode 100644
index 0000000..62fb83b
--- /dev/null
+++ b/excerpt-data/e424cce724cdc500/ClinGen_region_curation_list_GRCh37.tsv
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:2ba58ad6c8581290680a14c053d7d710eca26eea2e65e784ba3725ca9f2fa9e0
+size 18876
diff --git a/excerpt-data/e424cce724cdc500/url.txt b/excerpt-data/e424cce724cdc500/url.txt
new file mode 100644
index 0000000..08a3bf7
--- /dev/null
+++ b/excerpt-data/e424cce724cdc500/url.txt
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:f333e333e4b40baa09669aaee6c340107415fd83ada5d3076b89eb7452e1fcb2
+size 69
diff --git a/rules/output/annonars/clingen_dosage.smk b/rules/output/annonars/clingen_dosage.smk
new file mode 100644
index 0000000..70c0951
--- /dev/null
+++ b/rules/output/annonars/clingen_dosage.smk
@@ -0,0 +1,48 @@
+## Output rules related to ClinGen dosage sensitivity regions.
+
+
+rule annos_features_clingen_dosage_download_to_bed:  # -- convert ClinGen dosage sensitivity to BEd
+    input:
+        tsv="work/download/annos/{genome_release}/features/clingen_dosage/{date}/clingen_region_curation_list.tsv",
+    output:
+        bed="output/full/annonars/clingen-dosage-{genome_release}/{date}/clingen_region_curation_list.bed.gz",
+        bed_md5="output/full/annonars/clingen-dosage-{genome_release}/{date}/clingen_region_curation_list.bed.gz.md5",
+        bed_tbi="output/full/annonars/clingen-dosage-{genome_release}/{date}/clingen_region_curation_list.bed.gz.tbi",
+        bed_tbi_md5="output/full/annonars/clingen-dosage-{genome_release}/{date}/clingen_region_curation_list.bed.gz.tbi.md5",
+        spec_yaml="output/full/annonars/clingen-dosage-{genome_release}/{date}/clingen_region_curation_list.spec.yaml",
+    shell:
+        r"""
+        if [[ "{wildcards.genome_release}" == "grch37" ]]; then
+            chr_prefix=
+        else
+            chr_prefix=chr
+        fi
+
+        tail -n +8 {input.tsv} \
+        | awk -v chr_prefix=$chr_prefix -F $'\t' 'BEGIN {{ OFS=FS }}
+        {{
+            if ($4 == "tbd") {{
+                next;  /* skip, unmatched region */
+            }}
+
+            region=$4;
+            split($4, a, /[:-]/);
+            sub(/^chr/, "", a[1]);
+            print chr_prefix a[1], a[2] - 1, a[3], $0;
+        }}' \
+        | LC_ALL=C sort -k1,1V -k2,2n \
+        | bgzip -c \
+        > {output.bed}
+        tabix -f {output.bed}
+
+        md5sum {output.bed} > {output.bed_md5}
+        md5sum {output.bed_tbi} > {output.bed_tbi_md5}
+
+        varfish-db-downloader tpl \
+            --template rules/output/annonars/clingen_dosage.spec.yaml \
+            --value today={wildcards.date} \
+            --value genome_release={wildcards.genome_release} \
+            \
+            --value v_downloader={PV.downloader} \
+        > {output.spec_yaml}
+        """
diff --git a/rules/output/annonars/clingen_dosage.spec.yaml b/rules/output/annonars/clingen_dosage.spec.yaml
new file mode 100644
index 0000000..482d1c6
--- /dev/null
+++ b/rules/output/annonars/clingen_dosage.spec.yaml
@@ -0,0 +1,13 @@
+dc.identifier: annonars/features/clingen-dosage:{{ version }}-{{ genome_release }}
+dc.title: ClinGen Dosage Sensitivity
+dc.creator: NCBI ClinGen Team
+dc.contributor:
+  - VarFish Developer Teams
+dc.format: application/x-bed
+dc.date: {{ today }}
+x-version: {{ today }}
+x-genome-release: {{ genome_release }}
+dc.description: |
+  BED file with ClinGen dosage sensitivity regions.
+dc.source:
+  - https://search.clinicalgenome.org/kb/downloads#section_dosage
diff --git a/rules/work/annos/features/clingen_dosage.smk b/rules/work/annos/features/clingen_dosage.smk
new file mode 100644
index 0000000..6e2addd
--- /dev/null
+++ b/rules/work/annos/features/clingen_dosage.smk
@@ -0,0 +1,26 @@
+## Work rules related to ClinGen dosage sensitivity regions.
+
+
+rule annos_features_clingen_dosage_download:  # -- download ClinGen dosage sensitivity
+    output:
+        tsv="work/download/annos/{genome_release}/features/clingen_dosage/{date}/clingen_region_curation_list.tsv",
+        tsv_md5="work/download/annos/{genome_release}/features/clingen_dosage/{date}/clingen_region_curation_list.tsv.md5",
+    shell:
+        r"""
+        if [[ "$(date +%Y%m%d)" != "{wildcards.date}" ]] && [[ "{FORCE_TODAY}" != "True" ]]; then
+            >&2 echo "{wildcards.date} is not today"
+            exit 1
+        fi
+
+        if [[ "{wildcards.genome_release}" == "grch37" ]]; then
+            URL_RELEASE=GRCh37
+        else
+            URL_RELEASE=GRCh38
+        fi
+
+        wget --no-check-certificate \
+            -O {output.tsv} \
+            ftp://ftp.clinicalgenome.org/ClinGen_region_curation_list_${{URL_RELEASE}}.tsv
+
+        md5sum {output.tsv} > {output.tsv_md5}
+        """