Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Add support for parameter estimation #71

Open
tomvej opened this issue Aug 11, 2012 · 1 comment
Open

Add support for parameter estimation #71

tomvej opened this issue Aug 11, 2012 · 1 comment

Comments

@tomvej
Copy link
Member

tomvej commented Aug 11, 2012

Parasim so far supports mainly analysis of initial condition (i.e. simulation from different concentrations). However, in systems biology, parameter estimation and corresponding robustness analysis is more common.

Apparently, setting parameters as species does not work. Try running SIR model.
Octave seems unable to simulate species not present in reactions.

I have tried including "parameter species" in meaningless reaction (no change). Octave then has problems with convergence.

@tomvej
Copy link
Member Author

tomvej commented Aug 11, 2012

Copasi way: SBML species has argument constant which marks it is not simulated by reactions.

This may be a way of introducing parameter estimation without being bogged down by everything in listOfParameters. However, current ODE model does not recognize the constant argument.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Projects
None yet
Development

No branches or pull requests

1 participant