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methylation_global contains the average, weighted average and
fractional methylation values genome-wide per donor. Files in this
directory show these values in the CHM13 reference genome, with and
without centromeric satellites, as well as in hg38.
methylation_bins contain matrices of weighted averge methylation
when splitting the genome in 10kbp and 100kbp bins. It also
contains BED files showing the donor-corrected correlation between
each bin's methylation level and the donor age.
centromere contains both annotation and methylation data
regarding centromeric regions and subfamilies. This directory shows
the intervals defined as centromeric, the weighted average
methylation level in these regions per donor, and the correlation
between methylation levels in centromeres and centromeric repeat
subfamilies with age.
pmd contains both the methylation level and the donor-corrected
correlation for regions identified as PMDs in the 7 datasets
described in the manuscript.
hmr contains the coverage, count and size of HMRs proximal and
distal to promoters for each donor.
Data files
sample_donor_age.txt is a 3 column data frame with the sample id,
the donor id, and the age for each sample.
data_quality.txt shows the summary statistics for mapping and
quality control metrics for whole genome bisulfite sequencing data
for each dataset. These include: percentage of reads mapped
ambiguously and uniquely, bisulfite conversion rate, coverage and
depth of CpGs, and upper bound on CpG->TpG mutations.