diff --git a/libtiledbsoma/CMakeLists.txt b/libtiledbsoma/CMakeLists.txt
index 528c8c67d6..d092445439 100644
--- a/libtiledbsoma/CMakeLists.txt
+++ b/libtiledbsoma/CMakeLists.txt
@@ -248,11 +248,11 @@ else()
   # See https://www.reddit.com/r/cmake/comments/17d70h6/why_arent_generator_expressions_evaluated_for/
   # for this placeholder solution.
   set(TILEDBSOMA_SANITIZER_FLAG "")
-  list(APPEND TILEDBSOMA_SANITIZER_FLAG "\$<GENEX_EVAL:$<$<CONFIG:ASAN>: -fsanitize=address>>")
-  list(APPEND TILEDBSOMA_SANITIZER_FLAG "\$<GENEX_EVAL:$<$<CONFIG:LSAN>: -fsanitize=leak>>")
-  list(APPEND TILEDBSOMA_SANITIZER_FLAG "\$<GENEX_EVAL:$<$<CONFIG:TSAN>: -fsanitize=thread>>")
-  list(APPEND TILEDBSOMA_SANITIZER_FLAG "\$<GENEX_EVAL:$<$<CONFIG:UBSAN>: -fsanitize=undefined>>")
-  list(APPEND TILEDBSOMA_SANITIZER_FLAG "\$<GENEX_EVAL:$<$<CONFIG:MSAN>: -fsanitize=memory>>")
+  list(APPEND TILEDBSOMA_SANITIZER_FLAG "\$<GENEX_EVAL:$<$<CONFIG:ASAN>:-fsanitize=address>>")
+  list(APPEND TILEDBSOMA_SANITIZER_FLAG "\$<GENEX_EVAL:$<$<CONFIG:LSAN>:-fsanitize=leak>>")
+  list(APPEND TILEDBSOMA_SANITIZER_FLAG "\$<GENEX_EVAL:$<$<CONFIG:TSAN>:-fsanitize=thread>>")
+  list(APPEND TILEDBSOMA_SANITIZER_FLAG "\$<GENEX_EVAL:$<$<CONFIG:UBSAN>:-fsanitize=undefined>>")
+  list(APPEND TILEDBSOMA_SANITIZER_FLAG "\$<GENEX_EVAL:$<$<CONFIG:MSAN>:-fsanitize=memory>>")
 
 
   # Compiler specific additions:
diff --git a/libtiledbsoma/src/CMakeLists.txt b/libtiledbsoma/src/CMakeLists.txt
index 7cda33d946..3c29f4f967 100644
--- a/libtiledbsoma/src/CMakeLists.txt
+++ b/libtiledbsoma/src/CMakeLists.txt
@@ -9,7 +9,7 @@ set_source_files_properties(
 add_library(TILEDBSOMA_NANOARROW_OBJECT OBJECT
   ${CMAKE_CURRENT_SOURCE_DIR}/external/src/nanoarrow/nanoarrow.c
 )
-target_link_libraries(TILEDBSOMA_NANOARROW_OBJECT
+target_link_options(TILEDBSOMA_NANOARROW_OBJECT
   PRIVATE
     ${TILEDBSOMA_SANITIZER_FLAG}
 )
@@ -65,7 +65,7 @@ target_compile_options(TILEDB_SOMA_OBJECTS
     ${TILEDBSOMA_WERROR_OPTION}
     ${TILEDBSOMA_SANITIZER_FLAG}
 )
-target_link_libraries(TILEDB_SOMA_OBJECTS
+target_link_options(TILEDB_SOMA_OBJECTS
   PRIVATE
     ${TILEDBSOMA_SANITIZER_FLAG}
 )
@@ -121,6 +121,8 @@ else()
     PUBLIC
       TileDB::tiledb_shared
       spdlog::spdlog
+  )
+  target_link_options(tiledbsoma
     PRIVATE
       ${TILEDBSOMA_SANITIZER_FLAG}
   )
@@ -257,6 +259,8 @@ if(TILEDBSOMA_BUILD_CLI)
       # spdlog::spdlog
       tiledbsoma
       TileDB::tiledb_shared
+  )
+  target_link_options(tiledbsoma-cli
     PRIVATE
       ${TILEDBSOMA_SANITIZER_FLAG}
   )
diff --git a/libtiledbsoma/test/CMakeLists.txt b/libtiledbsoma/test/CMakeLists.txt
index 5baf2d54b6..73aa8949ab 100644
--- a/libtiledbsoma/test/CMakeLists.txt
+++ b/libtiledbsoma/test/CMakeLists.txt
@@ -37,10 +37,13 @@ add_executable(unit_soma
 
 target_link_libraries(unit_soma
   PRIVATE
-    ${TILEDBSOMA_SANITIZER_FLAG}
     Catch2::Catch2WithMain
     TileDB::tiledb_shared
 )
+target_link_options(unit_soma
+  PRIVATE
+    ${TILEDBSOMA_SANITIZER_FLAG}
+)
 
 target_include_directories(unit_soma
   PRIVATE