diff --git a/pyiron_workflow/channels.py b/pyiron_workflow/channels.py
index 04e9e9f2..64084eb6 100644
--- a/pyiron_workflow/channels.py
+++ b/pyiron_workflow/channels.py
@@ -652,7 +652,7 @@ def __call__(self, other: OutputSignal) -> None:
         self.received_signals.update([other.scoped_label])
         if (
             len(
-                set(c.scoped_label for c in self.connections).difference(
+                {c.scoped_label for c in self.connections}.difference(
                     self.received_signals
                 )
             )
diff --git a/pyiron_workflow/io.py b/pyiron_workflow/io.py
index 0293bb6c..5bb6f170 100644
--- a/pyiron_workflow/io.py
+++ b/pyiron_workflow/io.py
@@ -113,16 +113,16 @@ def __setitem__(self, key, value):
     def connections(self) -> list[Channel]:
         """All the unique connections across all channels"""
         return list(
-            set([connection for channel in self for connection in channel.connections])
+            {connection for channel in self for connection in channel.connections}
         )
 
     @property
     def connected(self):
-        return any([c.connected for c in self])
+        return any(c.connected for c in self)
 
     @property
     def fully_connected(self):
-        return all([c.connected for c in self])
+        return all(c.connected for c in self)
 
     def disconnect(self) -> list[tuple[Channel, Channel]]:
         """
@@ -182,11 +182,11 @@ def to_value_dict(self):
 
     def to_list(self):
         """A list of channel values (order not guaranteed)"""
-        return list(channel.value for channel in self.channel_dict.values())
+        return [channel.value for channel in self.channel_dict.values()]
 
     @property
     def ready(self):
-        return all([c.ready for c in self])
+        return all(c.ready for c in self)
 
     def activate_strict_hints(self):
         [c.activate_strict_hints() for c in self]
@@ -400,9 +400,7 @@ def set_input_values(self, *args, **kwargs) -> None:
                 f"Received {len(args)} args, but only have {len(self.inputs.labels)} "
                 f"input channels available"
             )
-        keyed_args = {
-            label: value for label, value in zip(self.inputs.labels, args, strict=False)
-        }
+        keyed_args = dict(zip(self.inputs.labels, args, strict=False))
 
         if len(set(keyed_args.keys()).intersection(kwargs.keys())) > 0:
             raise ValueError(
diff --git a/pyiron_workflow/mixin/preview.py b/pyiron_workflow/mixin/preview.py
index 21463d4c..08c06c47 100644
--- a/pyiron_workflow/mixin/preview.py
+++ b/pyiron_workflow/mixin/preview.py
@@ -197,7 +197,7 @@ def _build_outputs_preview(cls):
             type_hints = [None] * len(labels)
             # Note that this nicely differs from `NoneType`, which is the hint when
             # `None` is actually the hint!
-        return {label: hint for label, hint in zip(labels, type_hints, strict=False)}
+        return dict(zip(labels, type_hints, strict=False))
 
     @classmethod
     def _get_output_labels(cls):
diff --git a/pyiron_workflow/nodes/for_loop.py b/pyiron_workflow/nodes/for_loop.py
index b2b61979..af23faba 100644
--- a/pyiron_workflow/nodes/for_loop.py
+++ b/pyiron_workflow/nodes/for_loop.py
@@ -57,7 +57,7 @@ def dictionary_to_index_maps(
         nested_data_lengths = (
             []
             if (nested_keys is None or len(nested_keys) == 0)
-            else list(len(data[key]) for key in nested_keys)
+            else [len(data[key]) for key in nested_keys]
         )
     except TypeError as e:
         raise TypeError(
diff --git a/pyiron_workflow/topology.py b/pyiron_workflow/topology.py
index c60c9131..e96eeb76 100644
--- a/pyiron_workflow/topology.py
+++ b/pyiron_workflow/topology.py
@@ -184,7 +184,7 @@ def _set_run_connections_according_to_dag(nodes: dict[str, Node]) -> list[Node]:
 
     for node in nodes.values():
         upstream_connections = [con for inp in node.inputs for con in inp.connections]
-        upstream_nodes = set([c.owner for c in upstream_connections])
+        upstream_nodes = {c.owner for c in upstream_connections}
         upstream_rans = [n.signals.output.ran for n in upstream_nodes]
         node.signals.input.accumulate_and_run.connect(*upstream_rans)
     # Note: We can be super fast-and-loose here because the `nodes_to_data_digraph` call
@@ -225,7 +225,7 @@ def get_nodes_in_data_tree(node: Node) -> set[Node]:
     Get a set of all nodes from this one and upstream through data connections.
     """
     try:
-        nodes = set([node])
+        nodes = {node}
         for channel in node.inputs:
             for connection in channel.connections:
                 nodes = nodes.union(get_nodes_in_data_tree(connection.owner))
diff --git a/pyiron_workflow/type_hinting.py b/pyiron_workflow/type_hinting.py
index ccf15be2..f8619df0 100644
--- a/pyiron_workflow/type_hinting.py
+++ b/pyiron_workflow/type_hinting.py
@@ -37,18 +37,14 @@ def type_hint_to_tuple(type_hint) -> tuple:
 def type_hint_is_as_or_more_specific_than(hint, other) -> bool:
     hint_origin = typing.get_origin(hint)
     other_origin = typing.get_origin(other)
-    if set([hint_origin, other_origin]) & set([types.UnionType, typing.Union]):
+    if {hint_origin, other_origin} & {types.UnionType, typing.Union}:
         # If either hint is a union, turn both into tuples and call recursively
         return all(
-            [
-                any(
-                    [
-                        type_hint_is_as_or_more_specific_than(h, o)
-                        for o in type_hint_to_tuple(other)
-                    ]
-                )
-                for h in type_hint_to_tuple(hint)
-            ]
+            any(
+                type_hint_is_as_or_more_specific_than(h, o)
+                for o in type_hint_to_tuple(other)
+            )
+            for h in type_hint_to_tuple(hint)
         )
     elif hint_origin is None and other_origin is None:
         # Once both are raw classes, just do a subclass test
@@ -74,10 +70,8 @@ def type_hint_is_as_or_more_specific_than(hint, other) -> bool:
             elif len(other_args) == len(hint_args):
                 # If they both specify arguments, they should be more specific 1:1
                 return all(
-                    [
-                        type_hint_is_as_or_more_specific_than(h, o)
-                        for o, h in zip(other_args, hint_args, strict=False)
-                    ]
+                    type_hint_is_as_or_more_specific_than(h, o)
+                    for o, h in zip(other_args, hint_args, strict=False)
                 )
             else:
                 # Otherwise they both specify but a mis-matching number of args
@@ -85,15 +79,8 @@ def type_hint_is_as_or_more_specific_than(hint, other) -> bool:
         else:
             # Otherwise order doesn't matter so make sure the arguments are a subset
             return all(
-                [
-                    any(
-                        [
-                            type_hint_is_as_or_more_specific_than(h, o)
-                            for o in other_args
-                        ]
-                    )
-                    for h in hint_args
-                ]
+                any(type_hint_is_as_or_more_specific_than(h, o) for o in other_args)
+                for h in hint_args
             )
     else:
         # Lastly, if they both have origins, but different ones, fail
diff --git a/pyproject.toml b/pyproject.toml
index b9b433b7..650099bc 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -82,6 +82,8 @@ select = [
     "SIM",
     # isort
     "I",
+    # flake8-comprehensions
+    "C4",
 ]
 ignore = ["E501"] #ignore line-length violations
 
diff --git a/tests/integration/test_workflow.py b/tests/integration/test_workflow.py
index 16cba1c5..f1686be1 100644
--- a/tests/integration/test_workflow.py
+++ b/tests/integration/test_workflow.py
@@ -325,7 +325,7 @@ def test_failure(self):
                     f"written a recovery file, so after removing that the whole "
                     f"node directory for the workflow should be cleaned up."
                     f"Instead, {wf.as_path()} exists and has content "
-                    f"{[f for f in wf.as_path().iterdir()] if wf.as_path().is_dir() else None}",
+                    f"{list(wf.as_path().iterdir()) if wf.as_path().is_dir() else None}",
                 )
 
 
diff --git a/tests/unit/test_io.py b/tests/unit/test_io.py
index 32a58a2e..00586444 100644
--- a/tests/unit/test_io.py
+++ b/tests/unit/test_io.py
@@ -132,7 +132,7 @@ def test_conversion(self):
         )
 
     def test_iteration(self):
-        self.assertTrue(all([c.label in self.input.labels for c in self.input]))
+        self.assertTrue(all(c.label in self.input.labels for c in self.input))
 
     def test_connections_property(self):
         self.assertEqual(