-
Notifications
You must be signed in to change notification settings - Fork 2
/
90.Rmd
287 lines (152 loc) · 27.1 KB
/
90.Rmd
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
\cleardoublepage
# (APPENDIX) 별첨 {-}
# NONMEM 실행결과 {#nonmem-output}
[14장 NONMEM의 \$COVARIANCE](#cov)의 \@ref(cov-example)에서 언급된 NONMEM 실행결과를 별첨으로 수록하였다. 지면 관계상 작은 글자 크기로 수록되었으나 웹^[http://pipet.or.kr/books/basic/nonmem-output.html]에서 동일한 내용을 확인할 수 있다.
<!--
Command 10pt 11pt 12pt
\tiny 5 6 6
\scriptsize 7 8 8
\footnotesize 8 9 10
\small 9 10 10.95
\normalsize 10 10.95 12
\large 12 12 14.4
\Large 14.4 14.4 17.28
\LARGE 17.28 17.28 20.74
\huge 20.74 20.74 24.88
\Huge 24.88 24.88 24.88
https://tex.stackexchange.com/questions/24599/what-point-pt-font-size-are-large-etc
-->
\tiny
```{r, eval = FALSE, echo=TRUE}
*******************************************************************************************************
******************** ***
******************** FIRST ORDER ***
******************** STANDARD ERROR OF ESTIMATE ***
******************** ***
*******************************************************************************************************
THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********
TH 1 TH 2 TH 3
6.41E-01 1.68E+00 2.31E-02
OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ********
ETA1 ETA2 ETA3
ETA1 4.21E-01
ETA2 8.22E-02 1.98E-02
ETA3 3.40E-01 2.30E-02 2.89E-01
SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS ****
EPS1 EPS2
EPS1 3.58E-03
EPS2 ......... 3.21E-02
OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS *******
ETA1 ETA2 ETA3
ETA1 1.92E-01
ETA2 1.78E-01 5.59E-02
ETA3 2.10E-01 1.99E-01 2.89E-01
SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS ***
EPS1 EPS2
EPS1 1.63E-02
EPS2 ......... 6.88E-02
*******************************************************************************************************
******************** ***
******************** FIRST ORDER ***
******************** COVARIANCE MATRIX OF ESTIMATE ***
******************** ***
*******************************************************************************************************
TH 1 TH 2 TH 3 OM11 OM12 OM13 OM22 OM23 OM33 SG
TH 1 4.11E-01
TH 2 3.39E-01 2.84E+00
TH 3 5.75E-03 5.04E-03 5.32E-04
OM11 2.06E-01 3.37E-01 1.63E-03 1.77E-01
OM12 2.01E-03 3.48E-02 -1.04E-03 1.95E-02 6.75E-03
OM13 1.22E-01 1.49E-01 7.11E-03 5.75E-02 -1.01E-02 1.16E-01
OM22 -2.19E-03 1.28E-02 -2.50E-04 3.21E-03 1.50E-03 -2.83E-03 3.92E-04
OM23 1.00E-03 2.38E-02 6.31E-05 4.21E-03 8.56E-04 3.12E-03 2.32E-04 5.31E-04
OM33 6.70E-02 5.74E-02 6.22E-03 1.80E-02 -1.31E-02 9.40E-02 -3.27E-03 1.87E-03 8.38E-02
SG11 1.05E-03 1.81E-03 5.81E-05 5.14E-04 -7.52E-05 9.77E-04 -2.05E-05 2.79E-05 8.05E-04 1.28E
SG12 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......
SG22 -4.97E-03 -9.95E-03 -4.79E-04 -1.01E-03 9.53E-04 -3.86E-03 1.81E-04 2.20E-04 -3.40E-03 -2.82E
*******************************************************************************************************
******************** ***
******************** FIRST ORDER ***
******************** CORRELATION MATRIX OF ESTIMATE ***
******************** ***
*******************************************************************************************************
TH 1 TH 2 TH 3 OM11 OM12 OM13 OM22 OM23 OM33 SG
TH 1 6.41E-01
TH 2 3.14E-01 1.68E+00
TH 3 3.89E-01 1.30E-01 2.31E-02
OM11 7.63E-01 4.76E-01 1.68E-01 4.21E-01
OM12 3.81E-02 2.52E-01 -5.49E-01 5.64E-01 8.22E-02
OM13 5.57E-01 2.60E-01 9.06E-01 4.02E-01 -3.61E-01 3.40E-01
OM22 -1.73E-01 3.83E-01 -5.48E-01 3.85E-01 9.24E-01 -4.19E-01 1.98E-02
OM23 6.79E-02 6.14E-01 1.19E-01 4.35E-01 4.52E-01 3.98E-01 5.09E-01 2.30E-02
OM33 3.61E-01 1.18E-01 9.32E-01 1.48E-01 -5.50E-01 9.54E-01 -5.70E-01 2.80E-01 2.89E-01
SG11 4.58E-01 3.00E-01 7.04E-01 3.42E-01 -2.56E-01 8.02E-01 -2.90E-01 3.38E-01 7.78E-01 3.58E
SG12 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......
SG22 -2.42E-01 -1.84E-01 -6.47E-01 -7.52E-02 3.61E-01 -3.54E-01 2.84E-01 2.97E-01 -3.66E-01 -2.46E
*******************************************************************************************************
******************** ***
******************** FIRST ORDER ***
******************** INVERSE COVARIANCE MATRIX OF ESTIMATE ***
******************** ***
*******************************************************************************************************
TH 1 TH 2 TH 3 OM11 OM12 OM13 OM22 OM23 OM33 SG
TH 1 1.06E+02
TH 2 -6.86E+01 5.80E+01
TH 3 6.45E+03 -4.88E+03 5.90E+05
OM11 3.36E+02 -3.02E+02 2.70E+04 1.68E+03
OM12 -2.55E+03 2.18E+03 -1.89E+05 -1.17E+04 8.48E+04
OM13 -1.20E+03 9.40E+02 -9.03E+04 -5.09E+03 3.58E+04 1.67E+04
OM22 -3.88E+02 5.71E+02 -6.62E+04 -3.41E+03 1.37E+04 1.09E+04 7.22E+04
OM23 1.08E+04 -8.98E+03 7.96E+05 4.74E+04 -3.37E+05 -1.50E+05 -1.17E+05 1.42E+06
OM33 -4.97E+01 8.80E+01 -1.06E+04 -4.44E+02 3.32E+03 9.71E+02 2.83E+03 -1.41E+04 9.57E+02
SG11 1.17E+04 -1.01E+04 8.99E+05 5.33E+04 -3.79E+05 -1.67E+05 -1.39E+05 1.59E+06 -2.01E+04 2.03E
SG12 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......
SG22 -1.04E+03 1.00E+03 -4.72E+04 -4.88E+03 3.51E+04 1.43E+04 1.57E+04 -1.52E+05 9.39E+02 -1.70E
*******************************************************************************************************
******************** ***
******************** FIRST ORDER ***
******************** EIGENVALUES OF COR MATRIX OF ESTIMATE ***
******************** ***
*******************************************************************************************************
1 2 3 4 5 6 7 8 9 10
2.52E-04 9.67E-03 1.08E-02 2.33E-02 5.21E-02 2.98E-01 5.05E-01 9.11E-01 1.21E+00 3.21E
*******************************************************************************************************
******************** ***
******************** FIRST ORDER ***
******************** R MATRIX ***
******************** ***
*******************************************************************************************************
TH 1 TH 2 TH 3 OM11 OM12 OM13 OM22 OM23 OM33 SG
TH 1 1.79E+01
TH 2 -1.33E+00 5.51E-01
TH 3 -1.63E+02 -7.67E+00 3.43E+04
OM11 -4.13E+00 1.12E-01 8.60E+01 2.86E+01
OM12 2.16E+01 -1.46E+00 4.34E+02 -1.77E+02 1.93E+03
OM13 -1.10E+01 2.99E+00 -9.08E+01 -5.29E+01 2.11E+02 2.13E+02
OM22 1.02E+01 -1.65E+01 1.35E+01 2.73E+02 -4.27E+03 -1.40E+02 1.66E+04
OM23 5.23E+01 -1.83E+01 9.57E+02 1.64E+02 -1.42E+03 -5.56E+02 1.11E+03 4.05E+03
OM33 7.05E+00 -2.23E+00 -1.35E+03 2.45E+01 -4.37E+01 -1.51E+02 1.87E+01 1.31E+02 2.37E+02
SG11 2.49E+02 -1.21E+02 -7.03E+03 5.03E+01 -1.01E+03 9.63E+01 4.68E+03 -5.57E+02 -2.03E+01 1.93E
SG12 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......
SG22 -1.75E+00 -5.21E+00 -1.99E+03 6.01E+00 1.24E+02 -6.30E+01 -4.59E+01 -2.01E+02 9.27E+01 6.57E
*******************************************************************************************************
******************** ***
******************** FIRST ORDER ***
******************** S MATRIX ***
******************** ***
*******************************************************************************************************
TH 1 TH 2 TH 3 OM11 OM12 OM13 OM22 OM23 OM33 SG
TH 1 7.83E+01
TH 2 -4.65E+00 7.65E-01
TH 3 -1.30E+03 6.44E+01 1.84E+05
OM11 -1.19E+01 2.62E+00 -2.31E+02 1.84E+01
OM12 1.43E+02 -2.86E+01 8.40E+02 -1.72E+02 2.01E+03
OM13 -2.67E+01 2.39E-01 3.80E+03 -1.97E+01 5.17E+01 1.29E+02
OM22 -1.46E+02 2.95E+01 9.00E+03 2.92E+02 -3.81E+03 1.89E+02 1.20E+04
OM23 4.44E+01 1.08E+01 -1.08E+04 8.49E+01 -7.65E+02 -2.93E+02 6.68E+02 1.12E+03
OM33 1.40E+01 -4.41E+00 -6.40E+03 3.47E+00 8.80E+01 -1.56E+02 -7.13E+02 2.95E+02 3.28E+02
SG11 2.04E+03 -3.98E+02 -4.14E+03 -1.17E+03 8.92E+03 1.80E+03 -3.83E+03 -1.06E+04 1.81E+03 4.20E
SG12 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......
SG22 2.80E+02 -4.73E+01 -6.05E+04 -2.27E+01 6.71E+02 -1.11E+03 -3.49E+03 2.78E+03 2.36E+03 1.81E
```
\normalsize