diff --git a/src/patterns/data/manual/abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv b/src/patterns/data/manual/abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv
index db0a404d..8db0f52d 100644
--- a/src/patterns/data/manual/abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv
+++ b/src/patterns/data/manual/abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv
@@ -42,7 +42,6 @@ http://purl.obolibrary.org/obo/XPO_0136641	decreased apoptosis in zygote	GO:0006
 http://purl.obolibrary.org/obo/XPO_0136642	decreased apoptosis in animal cap	GO:0006915	apoptotic process	XAO:0000036	animal cap
 http://purl.obolibrary.org/obo/XPO_0136643	decreased apoptosis in animal cap inner layer	GO:0006915	apoptotic process	XAO:0000037	animal cap inner layer
 http://purl.obolibrary.org/obo/XPO_0136644	decreased apoptosis in animal cap outer layer	GO:0006915	apoptotic process	XAO:0000038	animal cap outer layer
-http://purl.obolibrary.org/obo/XPO_0136645	decreased apoptosis in head region	GO:0006915	apoptotic process	XAO:0000040	head region
 http://purl.obolibrary.org/obo/XPO_0136646	decreased apoptosis in epidermis inner layer	GO:0006915	apoptotic process	XAO:0000041	epidermis inner layer
 http://purl.obolibrary.org/obo/XPO_0136647	decreased apoptosis in neuroectoderm	GO:0006915	apoptotic process	XAO:0000042	neuroectoderm
 http://purl.obolibrary.org/obo/XPO_0136648	decreased apoptosis in neuroectoderm outer layer	GO:0006915	apoptotic process	XAO:0000043	neuroectoderm outer layer
@@ -1541,7 +1540,6 @@ http://purl.obolibrary.org/obo/XPO_0138192	decreased cell population proliferati
 http://purl.obolibrary.org/obo/XPO_0138193	decreased cell population proliferation in animal cap	GO:0008283	cell population proliferation	XAO:0000036	animal cap
 http://purl.obolibrary.org/obo/XPO_0138194	decreased cell population proliferation in animal cap inner layer	GO:0008283	cell population proliferation	XAO:0000037	animal cap inner layer
 http://purl.obolibrary.org/obo/XPO_0138195	decreased cell population proliferation in animal cap outer layer	GO:0008283	cell population proliferation	XAO:0000038	animal cap outer layer
-http://purl.obolibrary.org/obo/XPO_0138196	decreased cell population proliferation in head region	GO:0008283	cell population proliferation	XAO:0000040	head region
 http://purl.obolibrary.org/obo/XPO_0138197	decreased cell population proliferation in epidermis inner layer	GO:0008283	cell population proliferation	XAO:0000041	epidermis inner layer
 http://purl.obolibrary.org/obo/XPO_0138198	decreased cell population proliferation in neuroectoderm	GO:0008283	cell population proliferation	XAO:0000042	neuroectoderm
 http://purl.obolibrary.org/obo/XPO_0138199	decreased cell population proliferation in neuroectoderm outer layer	GO:0008283	cell population proliferation	XAO:0000043	neuroectoderm outer layer
diff --git a/src/patterns/data/manual/abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv b/src/patterns/data/manual/abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv
index cb338d84..322a9b06 100644
--- a/src/patterns/data/manual/abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv
+++ b/src/patterns/data/manual/abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv
@@ -37,7 +37,6 @@ http://purl.obolibrary.org/obo/XPO_0133539	increased apoptosis in zygote	GO:0006
 http://purl.obolibrary.org/obo/XPO_0133540	increased apoptosis in animal cap	GO:0006915	apoptotic process	XAO:0000036	animal cap
 http://purl.obolibrary.org/obo/XPO_0133541	increased apoptosis in animal cap inner layer	GO:0006915	apoptotic process	XAO:0000037	animal cap inner layer
 http://purl.obolibrary.org/obo/XPO_0133542	increased apoptosis in animal cap outer layer	GO:0006915	apoptotic process	XAO:0000038	animal cap outer layer
-http://purl.obolibrary.org/obo/XPO_0133543	increased apoptosis in head region	GO:0006915	apoptotic process	XAO:0000040	head region
 http://purl.obolibrary.org/obo/XPO_0133544	increased apoptosis in epidermis inner layer	GO:0006915	apoptotic process	XAO:0000041	epidermis inner layer
 http://purl.obolibrary.org/obo/XPO_0133545	increased apoptosis in neuroectoderm	GO:0006915	apoptotic process	XAO:0000042	neuroectoderm
 http://purl.obolibrary.org/obo/XPO_0133546	increased apoptosis in neuroectoderm outer layer	GO:0006915	apoptotic process	XAO:0000043	neuroectoderm outer layer
@@ -1536,7 +1535,6 @@ http://purl.obolibrary.org/obo/XPO_0135090	increased cell population proliferati
 http://purl.obolibrary.org/obo/XPO_0135091	increased cell population proliferation in animal cap	GO:0008283	cell population proliferation	XAO:0000036	animal cap
 http://purl.obolibrary.org/obo/XPO_0135092	increased cell population proliferation in animal cap inner layer	GO:0008283	cell population proliferation	XAO:0000037	animal cap inner layer
 http://purl.obolibrary.org/obo/XPO_0135093	increased cell population proliferation in animal cap outer layer	GO:0008283	cell population proliferation	XAO:0000038	animal cap outer layer
-http://purl.obolibrary.org/obo/XPO_0135094	increased cell population proliferation in head region	GO:0008283	cell population proliferation	XAO:0000040	head region
 http://purl.obolibrary.org/obo/XPO_0135095	increased cell population proliferation in epidermis inner layer	GO:0008283	cell population proliferation	XAO:0000041	epidermis inner layer
 http://purl.obolibrary.org/obo/XPO_0135096	increased cell population proliferation in neuroectoderm	GO:0008283	cell population proliferation	XAO:0000042	neuroectoderm
 http://purl.obolibrary.org/obo/XPO_0135097	increased cell population proliferation in neuroectoderm outer layer	GO:0008283	cell population proliferation	XAO:0000043	neuroectoderm outer layer
diff --git a/src/patterns/id_map.tsv b/src/patterns/id_map.tsv
index c66ecc57..ddac3248 100644
--- a/src/patterns/id_map.tsv
+++ b/src/patterns/id_map.tsv
@@ -13179,7 +13179,6 @@ GO:0006915-XAO:0000035-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocatio
 GO:0006915-XAO:0000036-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0133540
 GO:0006915-XAO:0000037-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0133541
 GO:0006915-XAO:0000038-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0133542
-GO:0006915-XAO:0000040-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0133543
 GO:0006915-XAO:0000041-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0133544
 GO:0006915-XAO:0000042-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0133545
 GO:0006915-XAO:0000043-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0133546
@@ -14727,7 +14726,6 @@ GO:0008283-XAO:0000035-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocatio
 GO:0008283-XAO:0000036-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0135091
 GO:0008283-XAO:0000037-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0135092
 GO:0008283-XAO:0000038-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0135093
-GO:0008283-XAO:0000040-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0135094
 GO:0008283-XAO:0000041-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0135095
 GO:0008283-XAO:0000042-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0135096
 GO:0008283-XAO:0000043-abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0135097
@@ -16275,7 +16273,6 @@ GO:0006915-XAO:0000035-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocatio
 GO:0006915-XAO:0000036-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0136642
 GO:0006915-XAO:0000037-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0136643
 GO:0006915-XAO:0000038-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0136644
-GO:0006915-XAO:0000040-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0136645
 GO:0006915-XAO:0000041-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0136646
 GO:0006915-XAO:0000042-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0136647
 GO:0006915-XAO:0000043-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0136648
@@ -17823,7 +17820,6 @@ GO:0008283-XAO:0000035-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocatio
 GO:0008283-XAO:0000036-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0138193
 GO:0008283-XAO:0000037-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0138194
 GO:0008283-XAO:0000038-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0138195
-GO:0008283-XAO:0000040-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0138196
 GO:0008283-XAO:0000041-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0138197
 GO:0008283-XAO:0000042-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0138198
 GO:0008283-XAO:0000043-abnormallyDecreasedOccurrenceOfBiologicalProcessInLocation.tsv	http://purl.obolibrary.org/obo/XPO_0138199
diff --git a/src/patterns/templates/xpo-replaced.owl b/src/patterns/templates/xpo-replaced.owl
index fe4cef52..bd904f5d 100644
--- a/src/patterns/templates/xpo-replaced.owl
+++ b/src/patterns/templates/xpo-replaced.owl
@@ -5080,6 +5080,16 @@
     
 
 
+    <!-- http://purl.obolibrary.org/obo/XPO_0133543 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/XPO_0133543">
+        <obo:IAO_0000125 rdf:resource="http://purl.obolibrary.org/obo/XPO_0133942"/>
+        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">obsolete increased apoptosis in head region</rdfs:label>
+        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/XPO_0134988 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/XPO_0134988">
@@ -5100,6 +5110,16 @@
     
 
 
+    <!-- http://purl.obolibrary.org/obo/XPO_0135094 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/XPO_0135094">
+        <obo:IAO_0000125 rdf:resource="http://purl.obolibrary.org/obo/XPO_0135493"/>
+        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">obsolete increased cell population proliferation in head region</rdfs:label>
+        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/XPO_0136539 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/XPO_0136539">
@@ -5120,6 +5140,16 @@
     
 
 
+    <!-- http://purl.obolibrary.org/obo/XPO_0136645 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/XPO_0136645">
+        <obo:IAO_0000125 rdf:resource="http://purl.obolibrary.org/obo/XPO_0137044"/>
+        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">obsolete decreased apoptosis in head region</rdfs:label>
+        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/XPO_0138090 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/XPO_0138090">
@@ -5140,6 +5170,16 @@
     
 
 
+    <!-- http://purl.obolibrary.org/obo/XPO_0138196 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/XPO_0138196">
+        <obo:IAO_0000125 rdf:resource="http://purl.obolibrary.org/obo/XPO_0138595"/>
+        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">obsolete decreased cell population proliferation in head region</rdfs:label>
+        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/XPO_0139641 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/XPO_0139641">
diff --git a/src/patterns/templates/xpo-replaced.tsv b/src/patterns/templates/xpo-replaced.tsv
index f11dba9a..309fffde 100644
--- a/src/patterns/templates/xpo-replaced.tsv
+++ b/src/patterns/templates/xpo-replaced.tsv
@@ -517,3 +517,7 @@ http://purl.obolibrary.org/obo/XPO_0133417	obsolete increased cilium motility in
 http://purl.obolibrary.org/obo/XPO_0133418	obsolete increased cilium motility in ciliated non-epidermal cell	true	http://purl.obolibrary.org/obo/XPO_0142007
 http://purl.obolibrary.org/obo/XPO_0133419	obsolete increased cilium motility in monociliated epidermal cell	true	http://purl.obolibrary.org/obo/XPO_0142008
 http://purl.obolibrary.org/obo/XPO_0133420	obsolete increased cilium motility in multiciliated epidermal cell	true	http://purl.obolibrary.org/obo/XPO_0142009
+http://purl.obolibrary.org/obo/XPO_0138196	obsolete decreased cell population proliferation in head region	true	http://purl.obolibrary.org/obo/XPO_0138595
+http://purl.obolibrary.org/obo/XPO_0136645	obsolete decreased apoptosis in head region	true	http://purl.obolibrary.org/obo/XPO_0137044
+http://purl.obolibrary.org/obo/XPO_0133543	obsolete increased apoptosis in head region	true	http://purl.obolibrary.org/obo/XPO_0133942
+http://purl.obolibrary.org/obo/XPO_0135094	obsolete increased cell population proliferation in head region	true	http://purl.obolibrary.org/obo/XPO_0135493