diff --git a/uberon-base.owl b/uberon-base.owl
index 32a770ead3..f243e703b5 100644
--- a/uberon-base.owl
+++ b/uberon-base.owl
@@ -14,7 +14,7 @@
      xmlns:terms="http://purl.org/dc/terms/"
      xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#">
     <owl:Ontology rdf:about="http://purl.obolibrary.org/obo/uberon/uberon-base.owl">
-        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/uberon/releases/2022-04-05/uberon-base.owl"/>
+        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/uberon/releases/2022-04-18/uberon-base.owl"/>
         <obo:IAO_0000700 rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000104"/>
         <obo:IAO_0000700 rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001062"/>
         <dc:creator rdf:resource="http://orcid.org/0000-0002-6601-2165"/>
@@ -178,7 +178,7 @@
         <oboInOwl:treat-xrefs-as-reverse-genus-differentia rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ZFA part_of NCBITaxon:7954</oboInOwl:treat-xrefs-as-reverse-genus-differentia>
         <oboInOwl:treat-xrefs-as-reverse-genus-differentia rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ZFS part_of NCBITaxon:7954</oboInOwl:treat-xrefs-as-reverse-genus-differentia>
         <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Aurelie Comte, Bill Bug, Catherine Leroy, Duncan Davidson and Trish Whetzel are also contributors. However their ORCIDs were not found.</rdfs:comment>
-        <owl:versionInfo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2022-04-05</owl:versionInfo>
+        <owl:versionInfo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2022-04-18</owl:versionInfo>
         <foaf:homepage rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://uberon.org</foaf:homepage>
     </owl:Ontology>
     
@@ -647703,7 +647703,7 @@
                 <owl:intersectionOf rdf:parseType="Collection">
                     <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UBERON_0000178"/>
                     <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0001025"/>
                         <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001637"/>
                     </owl:Restriction>
                 </owl:intersectionOf>
@@ -647754,7 +647754,7 @@
                 <owl:intersectionOf rdf:parseType="Collection">
                     <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UBERON_0000178"/>
                     <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0001025"/>
                         <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001638"/>
                     </owl:Restriction>
                 </owl:intersectionOf>
@@ -647804,7 +647804,7 @@
                 <owl:intersectionOf rdf:parseType="Collection">
                     <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UBERON_0000178"/>
                     <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0001025"/>
                         <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001982"/>
                     </owl:Restriction>
                 </owl:intersectionOf>
@@ -888872,6 +888872,37 @@ formulas. Modified from Cooper and Dawson 2009.</owl:annotatedTarget>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/UBERON_8470000 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_8470000">
+        <owl:equivalentClass>
+            <owl:Class>
+                <owl:intersectionOf rdf:parseType="Collection">
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UBERON_0000178"/>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0001025"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001987"/>
+                    </owl:Restriction>
+                </owl:intersectionOf>
+            </owl:Class>
+        </owl:equivalentClass>
+        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Blood located in the placenta.</obo:IAO_0000115>
+        <terms:contributor rdf:resource="http://orcid.org/0000-0002-1773-2692"/>
+        <terms:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-04-04T11:06:09Z</terms:date>
+        <oboInOwl:hasOBONamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#string">uberon</oboInOwl:hasOBONamespace>
+        <oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UBERON:8470000</oboInOwl:id>
+        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">placental blood</rdfs:label>
+    </owl:Class>
+    <owl:Axiom>
+        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_8470000"/>
+        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
+        <owl:annotatedTarget rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Blood located in the placenta.</owl:annotatedTarget>
+        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://orcid.org/0000-0001-6595-0902</oboInOwl:hasDbXref>
+        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">https://www.ncbi.nlm.nih.gov/books/NBK53254/</oboInOwl:hasDbXref>
+    </owl:Axiom>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/ZFA_0005228 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/ZFA_0005228">
diff --git a/uberon.obo b/uberon.obo
index 9a09c3343d..7435180a29 100644
--- a/uberon.obo
+++ b/uberon.obo
@@ -1,5 +1,5 @@
 format-version: 1.2
-data-version: releases/2022-04-05
+data-version: releases/2022-04-18
 subsetdef: 1_STAR ""
 subsetdef: 2_STAR ""
 subsetdef: 3_STAR ""
@@ -88,6 +88,7 @@ synonymtypedef: COMPARATIVE_PREFERRED "preferred term in the context of comparat
 synonymtypedef: DEPRECATED "A historic synonym, no longer encouraged"
 synonymtypedef: DEVELOPMENTAL "developmental term"
 synonymtypedef: DUBIOUS "dubious or contested synonym"
+synonymtypedef: Gene-based ""
 synonymtypedef: HOMOLOGY "a synonym made on the basis of a possibly homologous structure in another species"
 synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens"
 synonymtypedef: INCONSISTENT "indicates that a synonym is used in an inconsistent or confusing way, typically between species"
@@ -97,6 +98,8 @@ synonymtypedef: NON_AMNIOTE "synonym that is inappropriate for amniotes"
 synonymtypedef: NON_MAMMAL "synonym that is inappropriate for mammals"
 synonymtypedef: PENDING_REVIEW "expert consultation and attribution required"
 synonymtypedef: PLURAL "plural term"
+synonymtypedef: PRO-common-name ""
+synonymtypedef: PRO-short-label ""
 synonymtypedef: SENSU "taxonomic disambiguation"
 synonymtypedef: SYSTEMATIC "a systematic synonym used as the base name for design patterns"
 default-namespace: uberon
@@ -153,16 +156,20 @@ name: entity
 [Term]
 id: BFO:0000002
 name: continuant
+def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." []
 is_a: BFO:0000001 ! entity
+disjoint_from: BFO:0000003 ! occurrent
 
 [Term]
 id: BFO:0000003
 name: occurrent
+def: "An entity that has temporal parts and that happens, unfolds or develops through time." []
 is_a: BFO:0000001 ! entity
 
 [Term]
 id: BFO:0000004
 name: independent continuant
+def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." []
 def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"}
 is_a: BFO:0000002 ! continuant
 disjoint_from: BFO:0000020 ! specifically dependent continuant
@@ -175,6 +182,7 @@ is_a: BFO:0000141 ! immaterial entity
 [Term]
 id: BFO:0000015
 name: process
+def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." []
 is_a: BFO:0000003 ! occurrent
 
 [Term]
@@ -186,7 +194,9 @@ disjoint_from: BFO:0000023 ! role
 [Term]
 id: BFO:0000017
 name: realizable entity
+def: "A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." []
 is_a: BFO:0000020 ! specifically dependent continuant
+disjoint_from: BFO:0000019 ! quality
 
 [Term]
 id: BFO:0000019
@@ -197,12 +207,14 @@ is_a: BFO:0000020 ! specifically dependent continuant
 [Term]
 id: BFO:0000020
 name: specifically dependent continuant
+def: "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." []
 def: "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/050-003"}
 is_a: BFO:0000002 ! continuant
 
 [Term]
 id: BFO:0000023
 name: role
+def: "A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts." []
 is_a: BFO:0000017 ! realizable entity
 
 [Term]
@@ -230,6 +242,7 @@ is_a: BFO:0000016 ! disposition
 id: BFO:0000040
 name: material entity
 namespace: bfo
+def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." []
 is_a: BFO:0000004 ! independent continuant
 
 [Term]
@@ -250,6 +263,23 @@ is_a: BFO:0000004 ! independent continuant
 [Term]
 id: CHEBI:10545
 name: electron
+namespace: chebi_ontology
+def: "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV." []
+subset: 3_STAR
+synonym: "beta" RELATED [IUPAC]
+synonym: "beta(-)" RELATED [ChEBI]
+synonym: "beta-particle" RELATED [IUPAC]
+synonym: "e" RELATED [IUPAC]
+synonym: "e(-)" RELATED [UniProt]
+synonym: "e-" RELATED [KEGG_COMPOUND]
+synonym: "electron" EXACT [KEGG_COMPOUND]
+synonym: "electron" EXACT IUPAC_NAME [IUPAC]
+synonym: "electron" EXACT [ChEBI]
+synonym: "Elektron" RELATED [ChEBI]
+synonym: "negatron" RELATED [IUPAC]
+xref: KEGG:C05359
+xref: PMID:21614077 "Europe PMC"
+xref: Wikipedia:Electron
 is_a: CHEBI:36338 ! lepton
 
 [Term]
@@ -554,11 +584,17 @@ id: CHEBI:24431
 name: chemical entity
 namespace: chebi_ontology
 def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." []
+subset: 3_STAR
+synonym: "chemical entity" EXACT [UniProt]
 is_a: BFO:0000030 ! object
 
 [Term]
 id: CHEBI:24432
 name: biological role
+namespace: chebi_ontology
+def: "A role played by the molecular entity or part thereof within a biological context." []
+subset: 3_STAR
+synonym: "biological function" RELATED [ChEBI]
 is_a: CHEBI:50906 ! role
 
 [Term]
@@ -682,6 +718,17 @@ is_a: CHEBI:33300 ! pnictogen
 [Term]
 id: CHEBI:25585
 name: nonmetal atom
+namespace: chebi_ontology
+subset: 3_STAR
+synonym: "Nichtmetall" RELATED [ChEBI]
+synonym: "Nichtmetalle" RELATED [ChEBI]
+synonym: "no metal" RELATED [ChEBI]
+synonym: "no metales" RELATED [ChEBI]
+synonym: "non-metal" RELATED [ChEBI]
+synonym: "non-metaux" RELATED [ChEBI]
+synonym: "nonmetal" EXACT IUPAC_NAME [IUPAC]
+synonym: "nonmetal" RELATED [ChEBI]
+synonym: "nonmetals" RELATED [ChEBI]
 is_a: CHEBI:33250 ! atom
 
 [Term]
@@ -734,6 +781,17 @@ is_a: CHEBI:37577 ! heteroatomic molecular entity
 [Term]
 id: CHEBI:25805
 name: oxygen atom
+namespace: chebi_ontology
+subset: 3_STAR
+synonym: "8O" RELATED [IUPAC]
+synonym: "O" RELATED [IUPAC]
+synonym: "oxigeno" RELATED [ChEBI]
+synonym: "oxygen" EXACT IUPAC_NAME [IUPAC]
+synonym: "oxygen" RELATED [ChEBI]
+synonym: "oxygene" RELATED [ChEBI]
+synonym: "Sauerstoff" RELATED [ChEBI]
+xref: KEGG:C00007
+xref: WebElements:O
 is_a: CHEBI:25585 ! nonmetal atom
 is_a: CHEBI:33303 ! chalcogen
 relationship: has_role CHEBI:33937 ! macronutrient
@@ -923,6 +981,11 @@ is_a: CHEBI:64708 ! one-carbon compound
 [Term]
 id: CHEBI:33233
 name: fundamental particle
+namespace: chebi_ontology
+def: "A particle not known to have substructure." []
+subset: 3_STAR
+synonym: "elementary particle" EXACT IUPAC_NAME [IUPAC]
+synonym: "elementary particles" RELATED [ChEBI]
 is_a: CHEBI:36342 ! subatomic particle
 
 [Term]
@@ -968,6 +1031,18 @@ is_a: CHEBI:51447 ! organic univalent group
 [Term]
 id: CHEBI:33250
 name: atom
+namespace: chebi_ontology
+alt_id: CHEBI:22671
+alt_id: CHEBI:23907
+def: "A chemical entity constituting the smallest component of an element having the chemical properties of the element." []
+subset: 3_STAR
+synonym: "atom" EXACT IUPAC_NAME [IUPAC]
+synonym: "atome" RELATED [IUPAC]
+synonym: "atomo" RELATED [IUPAC]
+synonym: "atoms" RELATED [ChEBI]
+synonym: "atomus" RELATED [ChEBI]
+synonym: "element" RELATED [ChEBI]
+synonym: "elements" RELATED [ChEBI]
 is_a: CHEBI:24431 ! chemical entity
 relationship: has_part CHEBI:10545 ! electron
 relationship: has_part CHEBI:33252 ! atomic nucleus
@@ -975,12 +1050,32 @@ relationship: has_part CHEBI:33252 ! atomic nucleus
 [Term]
 id: CHEBI:33252
 name: atomic nucleus
+namespace: chebi_ontology
+def: "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons." []
+subset: 3_STAR
+synonym: "Atomkern" RELATED [ChEBI]
+synonym: "Kern" RELATED [ChEBI]
+synonym: "noyau" RELATED [IUPAC]
+synonym: "noyau atomique" RELATED [ChEBI]
+synonym: "nuclei" RELATED [ChEBI]
+synonym: "nucleo" RELATED [IUPAC]
+synonym: "nucleo atomico" RELATED [ChEBI]
+synonym: "nucleus" EXACT IUPAC_NAME [IUPAC]
+synonym: "nucleus atomi" RELATED [ChEBI]
 is_a: CHEBI:36347 ! nuclear particle
 relationship: has_part CHEBI:33253 ! nucleon
 
 [Term]
 id: CHEBI:33253
 name: nucleon
+namespace: chebi_ontology
+def: "Heavy nuclear particle: proton or neutron." []
+subset: 3_STAR
+synonym: "nucleon" EXACT [IUPAC]
+synonym: "nucleon" EXACT IUPAC_NAME [IUPAC]
+synonym: "nucleons" RELATED [ChEBI]
+synonym: "Nukleon" RELATED [ChEBI]
+synonym: "Nukleonen" RELATED [ChEBI]
 is_a: CHEBI:36339 ! baryon
 is_a: CHEBI:36347 ! nuclear particle
 
@@ -1026,6 +1121,10 @@ is_a: CHEBI:36358 ! polyatomic ion
 [Term]
 id: CHEBI:33284
 name: nutrient
+namespace: chebi_ontology
+def: "A nutrient is a food component that an organism uses to survive and grow." []
+subset: 3_STAR
+synonym: "nutrients" RELATED [ChEBI]
 is_a: CHEBI:78295 ! food component
 
 [Term]
@@ -1036,6 +1135,15 @@ is_a: CHEBI:50860 ! organic molecular entity
 [Term]
 id: CHEBI:33290
 name: food
+namespace: chebi_ontology
+def: "Any material that can be ingested by an organism." []
+subset: 3_STAR
+synonym: "food material" RELATED [ChEBI]
+synonym: "food materials" RELATED [ChEBI]
+synonym: "food role" RELATED [ChEBI]
+synonym: "foods" RELATED [ChEBI]
+synonym: "foodstuff" RELATED [ChEBI]
+synonym: "foodstuffs" RELATED [ChEBI]
 is_a: CHEBI:52211 ! physiological role
 relationship: has_part CHEBI:78295 ! food component
 
@@ -1065,6 +1173,22 @@ relationship: has_part CHEBI:33300 ! pnictogen
 [Term]
 id: CHEBI:33303
 name: chalcogen
+namespace: chebi_ontology
+def: "Any p-block element belonging to the group 16 family of the periodic table." []
+subset: 3_STAR
+synonym: "anfigeno" RELATED [ChEBI]
+synonym: "anfigenos" RELATED [ChEBI]
+synonym: "calcogeno" RELATED [ChEBI]
+synonym: "calcogenos" RELATED [ChEBI]
+synonym: "chalcogen" EXACT IUPAC_NAME [IUPAC]
+synonym: "chalcogene" RELATED [ChEBI]
+synonym: "chalcogenes" RELATED [ChEBI]
+synonym: "chalcogens" EXACT IUPAC_NAME [IUPAC]
+synonym: "Chalkogen" RELATED [ChEBI]
+synonym: "Chalkogene" RELATED [ChEBI]
+synonym: "group 16 elements" RELATED [ChEBI]
+synonym: "group VI elements" RELATED [ChEBI]
+xref: PMID:17084588 "Europe PMC"
 is_a: CHEBI:33560 ! p-block element atom
 
 [Term]
@@ -1081,6 +1205,13 @@ is_a: CHEBI:33560 ! p-block element atom
 [Term]
 id: CHEBI:33318
 name: main group element atom
+namespace: chebi_ontology
+def: "An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table." []
+subset: 3_STAR
+synonym: "Hauptgruppenelement" RELATED [ChEBI]
+synonym: "Hauptgruppenelemente" RELATED [ChEBI]
+synonym: "main group element" RELATED [ChEBI]
+synonym: "main group elements" EXACT IUPAC_NAME [IUPAC]
 is_a: CHEBI:33250 ! atom
 
 [Term]
@@ -1120,6 +1251,11 @@ is_a: CHEBI:33250 ! atom
 [Term]
 id: CHEBI:33560
 name: p-block element atom
+namespace: chebi_ontology
+def: "Any main group element atom belonging to the p-block of the periodic table." []
+subset: 3_STAR
+synonym: "p-block element" RELATED [ChEBI]
+synonym: "p-block elements" RELATED [ChEBI]
 is_a: CHEBI:33318 ! main group element atom
 
 [Term]
@@ -1270,6 +1406,8 @@ is_a: CHEBI:36357 ! polyatomic entity
 [Term]
 id: CHEBI:33937
 name: macronutrient
+namespace: chebi_ontology
+subset: 1_STAR
 is_a: CHEBI:33284 ! nutrient
 
 [Term]
@@ -1442,38 +1580,67 @@ is_a: CHEBI:47882 ! cyclic polypyrrole
 [Term]
 id: CHEBI:36338
 name: lepton
+namespace: chebi_ontology
+def: "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin)." []
+subset: 3_STAR
+synonym: "leptons" RELATED [ChEBI]
 is_a: CHEBI:33233 ! fundamental particle
 is_a: CHEBI:36340 ! fermion
 
 [Term]
 id: CHEBI:36339
 name: baryon
+namespace: chebi_ontology
+def: "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy)." []
+subset: 3_STAR
+synonym: "baryons" RELATED [ChEBI]
 is_a: CHEBI:36340 ! fermion
 is_a: CHEBI:36344 ! hadron
 
 [Term]
 id: CHEBI:36340
 name: fermion
+namespace: chebi_ontology
+def: "Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi." []
+subset: 3_STAR
+synonym: "fermion" EXACT IUPAC_NAME [IUPAC]
+synonym: "fermions" RELATED [ChEBI]
 is_a: CHEBI:36342 ! subatomic particle
 
 [Term]
 id: CHEBI:36342
 name: subatomic particle
+namespace: chebi_ontology
+def: "A particle smaller than an atom." []
+subset: 3_STAR
+synonym: "subatomic particles" RELATED [ChEBI]
 is_a: BFO:0000040 ! material entity
 
 [Term]
 id: CHEBI:36343
 name: composite particle
+namespace: chebi_ontology
+def: "A subatomic particle known to have substructure (i.e. consisting of smaller particles)." []
+subset: 3_STAR
+synonym: "composite particles" RELATED [ChEBI]
 is_a: CHEBI:36342 ! subatomic particle
 
 [Term]
 id: CHEBI:36344
 name: hadron
+namespace: chebi_ontology
+def: "Hadron is a subatomic particle which experiences the strong force." []
+subset: 3_STAR
+synonym: "hadrons" RELATED [ChEBI]
 is_a: CHEBI:36343 ! composite particle
 
 [Term]
 id: CHEBI:36347
 name: nuclear particle
+namespace: chebi_ontology
+def: "A nucleus or any of its constituents in any of their energy states." []
+subset: 3_STAR
+synonym: "nuclear particle" EXACT IUPAC_NAME [IUPAC]
 is_a: CHEBI:36342 ! subatomic particle
 
 [Term]
@@ -1769,6 +1936,9 @@ relationship: has_part CHEBI:27594 ! carbon atom
 [Term]
 id: CHEBI:50906
 name: role
+namespace: chebi_ontology
+def: "A role is particular behaviour which a material entity may exhibit." []
+subset: 3_STAR
 
 [Term]
 id: CHEBI:50967
@@ -1815,6 +1985,8 @@ is_a: CHEBI:33832 ! organic cyclic compound
 [Term]
 id: CHEBI:52211
 name: physiological role
+namespace: chebi_ontology
+subset: 1_STAR
 is_a: CHEBI:24432 ! biological role
 
 [Term]
@@ -1937,6 +2109,12 @@ is_a: CHEBI:51086 ! chemical role
 [Term]
 id: CHEBI:78295
 name: food component
+namespace: chebi_ontology
+def: "Any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants." []
+subset: 3_STAR
+synonym: "dietary component" RELATED [ChEBI]
+synonym: "dietary components" RELATED [ChEBI]
+synonym: "food components" RELATED [ChEBI]
 is_a: CHEBI:52211 ! physiological role
 
 [Term]
@@ -28915,6 +29093,18 @@ is_a: PATO:0001842 ! acidity
 [Term]
 id: GO:0000003
 name: reproduction
+namespace: biological_process
+alt_id: GO:0019952
+alt_id: GO:0050876
+def: "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732]
+subset: goslim_agr
+subset: goslim_chembl
+subset: goslim_flybase_ribbon
+subset: goslim_generic
+subset: goslim_pir
+subset: goslim_plant
+synonym: "reproductive physiological process" EXACT []
+xref: Wikipedia:Reproduction
 is_a: GO:0008150 ! biological_process
 
 [Term]
@@ -28947,6 +29137,13 @@ relationship: regulates GO:0009064 ! glutamine family amino acid metabolic proce
 [Term]
 id: GO:0001101
 name: response to acid chemical
+namespace: biological_process
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn]
+comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead.
+subset: gocheck_do_not_manually_annotate
+synonym: "response to acid" BROAD []
+synonym: "response to acid anion" RELATED []
+synonym: "response to oxoanion" RELATED []
 is_a: GO:0042221 ! response to chemical
 
 [Term]
@@ -29605,6 +29802,9 @@ relationship: part_of GO:0000003 ! reproduction
 [Term]
 id: GO:0003008
 name: system process
+namespace: biological_process
+def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio]
+synonym: "organ system process" EXACT []
 is_a: GO:0032501 ! multicellular organismal process
 
 [Term]
@@ -29620,6 +29820,10 @@ is_a: GO:0003008 ! system process
 [Term]
 id: GO:0003014
 name: renal system process
+namespace: biological_process
+def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10]
+synonym: "excretory system process" EXACT []
+synonym: "kidney system process" RELATED []
 is_a: GO:0003008 ! system process
 
 [Term]
@@ -29845,6 +30049,11 @@ id: GO:0003674
 name: molecular_function
 is_a: BFO:0000015 ! process
 
+[Term]
+id: GO:0003824
+name: catalytic activity
+is_a: GO:0003674 ! molecular_function
+
 [Term]
 id: GO:0004888
 name: transmembrane signaling receptor activity
@@ -30230,7 +30439,26 @@ is_a: GO:0008152 ! metabolic process
 [Term]
 id: GO:0006810
 name: transport
+namespace: biological_process
+alt_id: GO:0015457
+alt_id: GO:0015460
+alt_id: GO:0044765
+def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]
+comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport.
+subset: gocheck_do_not_annotate
+subset: goslim_aspergillus
+subset: goslim_candida
+subset: goslim_chembl
+subset: goslim_generic
+subset: goslim_metagenomics
+subset: goslim_pir
+subset: goslim_plant
+synonym: "single-organism transport" RELATED []
+synonym: "small molecule transport" NARROW []
+synonym: "solute:solute exchange" NARROW []
 is_a: GO:0051234 ! establishment of localization
+created_by: jl
+creation_date: 2012-12-13T16:25:32Z
 
 [Term]
 id: GO:0006811
@@ -30331,6 +30559,19 @@ relationship: regulates GO:0006941 ! striated muscle contraction
 [Term]
 id: GO:0006950
 name: response to stress
+namespace: biological_process
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
+comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
+subset: gocheck_do_not_manually_annotate
+subset: goslim_aspergillus
+subset: goslim_candida
+subset: goslim_chembl
+subset: goslim_drosophila
+subset: goslim_generic
+subset: goslim_metagenomics
+subset: goslim_plant
+synonym: "response to abiotic stress" RELATED []
+synonym: "response to biotic stress" RELATED []
 is_a: GO:0050896 ! response to stimulus
 
 [Term]
@@ -30539,6 +30780,10 @@ is_a: GO:0032501 ! multicellular organismal process
 [Term]
 id: GO:0007588
 name: excretion
+namespace: biological_process
+def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023]
+subset: goslim_pir
+xref: Wikipedia:Excretion
 is_a: GO:0003008 ! system process
 
 [Term]
@@ -30569,32 +30814,73 @@ is_a: GO:0050878 ! regulation of body fluid levels
 [Term]
 id: GO:0007600
 name: sensory perception
+namespace: biological_process
+def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph]
+subset: goslim_drosophila
+xref: Wikipedia:Perception
 is_a: GO:0050877 ! nervous system process
 
 [Term]
 id: GO:0007601
 name: visual perception
+namespace: biological_process
+def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
+synonym: "sense of sight" EXACT []
+synonym: "sensory visual perception" EXACT []
+synonym: "vision" EXACT []
+xref: Wikipedia:Visual_perception
 is_a: GO:0050953 ! sensory perception of light stimulus
 
 [Term]
 id: GO:0007605
 name: sensory perception of sound
+namespace: biological_process
+def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
+synonym: "hearing" EXACT []
+synonym: "perception of sound" EXACT []
+xref: Wikipedia:Hearing_(sense)
 is_a: GO:0050954 ! sensory perception of mechanical stimulus
 
 [Term]
 id: GO:0007606
 name: sensory perception of chemical stimulus
+namespace: biological_process
+def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
+synonym: "chemosensory perception" EXACT []
 is_a: GO:0007600 ! sensory perception
 
 [Term]
 id: GO:0007608
 name: sensory perception of smell
+namespace: biological_process
+def: "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai]
+synonym: "olfaction" EXACT []
+synonym: "scent perception" EXACT []
+synonym: "sense of smell" EXACT []
+synonym: "smell perception" EXACT []
+xref: Wikipedia:Olfaction
 is_a: GO:0007606 ! sensory perception of chemical stimulus
 
 [Term]
 id: GO:0007610
 name: behavior
+namespace: biological_process
+alt_id: GO:0023032
+alt_id: GO:0044708
+alt_id: GO:0044709
+def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
+comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).
+subset: gocheck_do_not_manually_annotate
+subset: goslim_agr
+subset: goslim_flybase_ribbon
+synonym: "behavioral response to stimulus" EXACT []
+synonym: "behaviour" EXACT []
+synonym: "behavioural response to stimulus" EXACT []
+synonym: "single-organism behavior" RELATED []
+xref: Wikipedia:Behavior
 is_a: GO:0050896 ! response to stimulus
+created_by: jl
+creation_date: 2012-09-20T14:06:08Z
 
 [Term]
 id: GO:0007611
@@ -30615,6 +30901,10 @@ is_a: GO:0007611 ! learning or memory
 [Term]
 id: GO:0007617
 name: mating behavior
+namespace: biological_process
+def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph]
+synonym: "mating behaviour" EXACT []
+xref: Wikipedia:Mating_behaviour
 is_a: GO:0019098 ! reproductive behavior
 intersection_of: GO:0007610 ! behavior
 intersection_of: part_of GO:0007618 ! mating
@@ -30623,39 +30913,97 @@ relationship: part_of GO:0007618 ! mating
 [Term]
 id: GO:0007618
 name: mating
+namespace: biological_process
+def: "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546]
 is_a: GO:0044703 ! multi-organism reproductive process
 relationship: part_of GO:0019953 ! sexual reproduction
 
 [Term]
 id: GO:0007620
 name: copulation
+namespace: biological_process
+def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544]
 is_a: GO:0007618 ! mating
 
 [Term]
 id: GO:0007622
 name: rhythmic behavior
+namespace: biological_process
+def: "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr]
+synonym: "rhythmic behavioral response to stimulus" EXACT []
+synonym: "rhythmic behaviour" EXACT []
+synonym: "rhythmic behavioural response to stimulus" EXACT []
 is_a: GO:0007610 ! behavior
 is_a: GO:0048511 ! rhythmic process
 
 [Term]
 id: GO:0007623
 name: circadian rhythm
+namespace: biological_process
+alt_id: GO:0050895
+def: "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
+subset: goslim_drosophila
+subset: goslim_plant
+synonym: "circadian process" EXACT []
+synonym: "circadian response" RELATED []
+synonym: "response to circadian rhythm" RELATED []
+xref: Wikipedia:Circadian_rhythm
 is_a: GO:0048511 ! rhythmic process
 
 [Term]
 id: GO:0007625
 name: grooming behavior
+namespace: biological_process
+def: "The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl, GOC:pr]
+synonym: "groom" EXACT []
+synonym: "grooming behaviour" EXACT []
 is_a: GO:0007610 ! behavior
 
 [Term]
 id: GO:0007626
 name: locomotory behavior
+namespace: biological_process
+def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
+subset: goslim_drosophila
+synonym: "behavior via locomotion" EXACT []
+synonym: "locomotion in response to stimulus" EXACT []
+synonym: "locomotory behavioral response to stimulus" EXACT []
+synonym: "locomotory behaviour" EXACT []
+synonym: "locomotory behavioural response to stimulus" EXACT []
 is_a: GO:0007610 ! behavior
 
 [Term]
 id: GO:0007631
 name: feeding behavior
+namespace: biological_process
+alt_id: GO:0044366
+alt_id: GO:0044367
+alt_id: GO:0044368
+alt_id: GO:0044369
+alt_id: GO:0044370
+alt_id: GO:0044371
+alt_id: GO:0044372
+def: "Behavior associated with the intake of food." [GOC:mah]
+comment: See also the biological process term 'behavior ; GO:0007610'.
+synonym: "behavioral response to food" EXACT []
+synonym: "behavioural response to food" EXACT []
+synonym: "eating" NARROW []
+synonym: "feeding behaviour" EXACT []
+synonym: "feeding from phloem of other organism" NARROW []
+synonym: "feeding from plant phloem" NARROW []
+synonym: "feeding from tissue of other organism" NARROW []
+synonym: "feeding from vascular tissue of another organism" NARROW []
+synonym: "feeding from xylem of other organism" NARROW []
+synonym: "feeding on blood of other organism" NARROW []
+synonym: "feeding on or from other organism" NARROW []
+synonym: "feeding on plant sap" NARROW []
+synonym: "hematophagy" NARROW []
+synonym: "injection of substance into other organism during feeding on blood of other organism" NARROW []
+synonym: "taking of blood meal" NARROW []
+xref: Wikipedia:List_of_feeding_behaviours
 is_a: GO:0007610 ! behavior
+created_by: jl
+creation_date: 2011-10-27T03:53:33Z
 
 [Term]
 id: GO:0007635
@@ -30685,10 +31033,28 @@ is_a: GO:0033036 ! macromolecule localization
 id: GO:0008150
 name: biological_process
 namespace: biological_process
+alt_id: GO:0000004
+alt_id: GO:0007582
+alt_id: GO:0044699
 def: "A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]
 comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.
+subset: goslim_aspergillus
+subset: goslim_candida
+subset: goslim_chembl
+subset: goslim_generic
+subset: goslim_metagenomics
+subset: goslim_pir
+subset: goslim_plant
+subset: goslim_pombe
+subset: goslim_yeast
 synonym: "biological process" EXACT []
+synonym: "physiological process" EXACT []
+synonym: "single organism process" RELATED []
+synonym: "single-organism process" RELATED []
+xref: Wikipedia:Biological_process
 is_a: BFO:0000015 ! process
+created_by: jl
+creation_date: 2012-09-19T15:05:24Z
 
 [Term]
 id: GO:0008152
@@ -30837,6 +31203,9 @@ is_a: GO:0044042 ! glucan metabolic process
 [Term]
 id: GO:0009266
 name: response to temperature stimulus
+namespace: biological_process
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb]
+synonym: "response to thermal stimulus" EXACT []
 is_a: GO:0009628 ! response to abiotic stimulus
 
 [Term]
@@ -30859,12 +31228,21 @@ is_a: GO:0009628 ! response to abiotic stimulus
 [Term]
 id: GO:0009414
 name: response to water deprivation
+namespace: biological_process
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [GOC:lr]
+synonym: "drought tolerance" RELATED []
+synonym: "response to dehydration" EXACT []
+synonym: "response to drought" EXACT []
+synonym: "response to thirst" EXACT []
 is_a: GO:0006950 ! response to stress
 is_a: GO:0009415 ! response to water
 
 [Term]
 id: GO:0009415
 name: response to water
+namespace: biological_process
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl]
+synonym: "response to water stimulus" EXACT [GOC:dos]
 is_a: GO:0001101 ! response to acid chemical
 is_a: GO:0009628 ! response to abiotic stimulus
 is_a: GO:0010035 ! response to inorganic substance
@@ -30884,12 +31262,18 @@ is_a: GO:0032787 ! monocarboxylic acid metabolic process
 [Term]
 id: GO:0009581
 name: detection of external stimulus
+namespace: biological_process
+def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
+synonym: "perception of external stimulus" RELATED []
 is_a: GO:0009605 ! response to external stimulus
 is_a: GO:0051606 ! detection of stimulus
 
 [Term]
 id: GO:0009582
 name: detection of abiotic stimulus
+namespace: biological_process
+def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
+synonym: "perception of abiotic stimulus" RELATED []
 is_a: GO:0009628 ! response to abiotic stimulus
 is_a: GO:0051606 ! detection of stimulus
 
@@ -30915,12 +31299,26 @@ is_a: GO:0009629 ! response to gravity
 [Term]
 id: GO:0009593
 name: detection of chemical stimulus
+namespace: biological_process
+def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
+synonym: "chemoperception" EXACT []
+synonym: "chemoreception" RELATED []
+synonym: "detection of chemical substance" EXACT []
+synonym: "perception of chemical stimulus" RELATED []
+synonym: "perception of chemical substance" RELATED []
 is_a: GO:0051606 ! detection of stimulus
 relationship: part_of GO:0042221 ! response to chemical
 
 [Term]
 id: GO:0009605
 name: response to external stimulus
+namespace: biological_process
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]
+comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
+subset: gocheck_do_not_manually_annotate
+subset: goslim_drosophila
+subset: goslim_plant
+synonym: "response to environmental stimulus" EXACT []
 is_a: GO:0050896 ! response to stimulus
 
 [Term]
@@ -30931,12 +31329,23 @@ is_a: GO:0006950 ! response to stress
 [Term]
 id: GO:0009612
 name: response to mechanical stimulus
+namespace: biological_process
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
+synonym: "chemi-mechanical coupling" RELATED []
+synonym: "mechanical stimulus response" EXACT []
 is_a: GO:0009605 ! response to external stimulus
 is_a: GO:0009628 ! response to abiotic stimulus
 
 [Term]
 id: GO:0009628
 name: response to abiotic stimulus
+namespace: biological_process
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]
+comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
+subset: gocheck_do_not_manually_annotate
+subset: goslim_metagenomics
+subset: goslim_plant
+synonym: "response to abiotic stress" NARROW []
 is_a: GO:0050896 ! response to stimulus
 
 [Term]
@@ -31109,6 +31518,8 @@ is_a: GO:0042221 ! response to chemical
 [Term]
 id: GO:0010035
 name: response to inorganic substance
+namespace: biological_process
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm]
 is_a: GO:0042221 ! response to chemical
 
 [Term]
@@ -31604,6 +32015,11 @@ is_a: GO:0071840 ! cellular component organization or biogenesis
 [Term]
 id: GO:0016048
 name: detection of temperature stimulus
+namespace: biological_process
+def: "The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal." [GOC:hb]
+synonym: "detection of temperature" EXACT []
+synonym: "detection of thermal stimulus" EXACT []
+synonym: "perception of temperature" RELATED []
 is_a: GO:0009266 ! response to temperature stimulus
 is_a: GO:0009581 ! detection of external stimulus
 is_a: GO:0009582 ! detection of abiotic stimulus
@@ -31645,6 +32061,11 @@ name: vesicle-mediated transport
 is_a: GO:0006810 ! transport
 is_a: GO:0009987 ! cellular process
 
+[Term]
+id: GO:0016301
+name: kinase activity
+is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups
+
 [Term]
 id: GO:0016331
 name: morphogenesis of embryonic epithelium
@@ -31682,6 +32103,16 @@ intersection_of: GO:0005737 ! cytoplasm
 intersection_of: part_of CL:0000187 ! muscle cell
 relationship: part_of CL:0000187 ! muscle cell
 
+[Term]
+id: GO:0016740
+name: transferase activity
+is_a: GO:0003824 ! catalytic activity
+
+[Term]
+id: GO:0016772
+name: transferase activity, transferring phosphorus-containing groups
+is_a: GO:0016740 ! transferase activity
+
 [Term]
 id: GO:0017145
 name: stem cell division
@@ -31712,11 +32143,22 @@ is_a: GO:1901615 ! organic hydroxy compound metabolic process
 [Term]
 id: GO:0019098
 name: reproductive behavior
+namespace: biological_process
+alt_id: GO:0033057
+alt_id: GO:0044704
+def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr]
+subset: goslim_drosophila
+synonym: "multicellular organism reproductive behavior" NARROW []
+synonym: "reproductive behavior in a multicellular organism" EXACT []
+synonym: "reproductive behaviour" EXACT []
+synonym: "single-organism reproductive behavior" RELATED []
 is_a: GO:0007610 ! behavior
 is_a: GO:0048609 ! multicellular organismal reproductive process
 intersection_of: GO:0007610 ! behavior
 intersection_of: part_of GO:0000003 ! reproduction
 relationship: part_of GO:0000003 ! reproduction
+created_by: jl
+creation_date: 2012-09-19T16:01:37Z
 
 [Term]
 id: GO:0019216
@@ -31751,6 +32193,11 @@ relationship: part_of GO:0050884 ! neuromuscular process controlling posture
 [Term]
 id: GO:0019233
 name: sensory perception of pain
+namespace: biological_process
+def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [GOC:curators]
+synonym: "nociception" EXACT []
+synonym: "perception of physiological pain" NARROW []
+xref: Wikipedia:Nociception
 is_a: GO:0007600 ! sensory perception
 
 [Term]
@@ -31783,6 +32230,10 @@ is_a: GO:0043436 ! oxoacid metabolic process
 [Term]
 id: GO:0019953
 name: sexual reproduction
+namespace: biological_process
+def: "A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny." [GOC:jl, GOC:kmv, GOC:krc, GOC:tb, ISBN:0387520546, Wikipedia:Sexual_reproduction]
+comment: Sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.
+xref: Wikipedia:Sexual_reproduction
 is_a: GO:0000003 ! reproduction
 is_a: GO:0044703 ! multi-organism reproductive process
 
@@ -31854,6 +32305,8 @@ relationship: positively_regulates GO:0098609 ! cell-cell adhesion
 [Term]
 id: GO:0022410
 name: circadian sleep/wake cycle process
+namespace: biological_process
+def: "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:isa_complete]
 is_a: GO:0048512 ! circadian behavior
 relationship: part_of GO:0042745 ! circadian sleep/wake cycle
 
@@ -31869,10 +32322,16 @@ relationship: part_of GO:0032504 ! multicellular organism reproduction
 [Term]
 id: GO:0022414
 name: reproductive process
+namespace: biological_process
+alt_id: GO:0044702
+def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]
+synonym: "single organism reproductive process" RELATED []
 is_a: GO:0008150 ! biological_process
 intersection_of: GO:0008150 ! biological_process
 intersection_of: part_of GO:0000003 ! reproduction
 relationship: part_of GO:0000003 ! reproduction
+created_by: jl
+creation_date: 2012-09-19T15:56:06Z
 
 [Term]
 id: GO:0022600
@@ -32170,6 +32629,9 @@ relationship: negatively_regulates GO:0016477 ! cell migration
 [Term]
 id: GO:0030421
 name: defecation
+namespace: biological_process
+def: "The expulsion of feces from the rectum." [GOC:mah]
+xref: Wikipedia:Defecation
 is_a: GO:0007588 ! excretion
 
 [Term]
@@ -32186,6 +32648,13 @@ relationship: part_of GO:0097447 ! dendritic tree
 [Term]
 id: GO:0030431
 name: sleep
+namespace: biological_process
+def: "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
+subset: goslim_pir
+synonym: "diapause" RELATED []
+synonym: "dormancy" RELATED []
+synonym: "lethargus" RELATED []
+xref: Wikipedia:Sleep
 is_a: GO:0032501 ! multicellular organismal process
 
 [Term]
@@ -32491,6 +32960,11 @@ relationship: part_of GO:0030216 ! keratinocyte differentiation
 [Term]
 id: GO:0031644
 name: regulation of nervous system process
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system." [GOC:dph, GOC:mah, GOC:tb]
+synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb]
+synonym: "regulation of neurological system process" EXACT []
+synonym: "regulation of neurophysiological process" EXACT []
 is_a: GO:0044057 ! regulation of system process
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0050877 ! nervous system process
@@ -32604,6 +33078,9 @@ is_a: GO:0043227 ! membrane-bounded organelle
 [Term]
 id: GO:0031987
 name: locomotion involved in locomotory behavior
+namespace: biological_process
+def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
+synonym: "locomotion during locomotory behaviour" EXACT []
 is_a: GO:0040011 ! locomotion
 intersection_of: GO:0040011 ! locomotion
 intersection_of: part_of GO:0007626 ! locomotory behavior
@@ -32622,6 +33099,10 @@ relationship: positively_regulates GO:0030073 ! insulin secretion
 [Term]
 id: GO:0032101
 name: regulation of response to external stimulus
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]
+comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
+subset: gocheck_do_not_manually_annotate
 is_a: GO:0048583 ! regulation of response to stimulus
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0009605 ! response to external stimulus
@@ -32838,7 +33319,16 @@ relationship: part_of GO:0015629 ! actin cytoskeleton
 [Term]
 id: GO:0032501
 name: multicellular organismal process
+namespace: biological_process
+alt_id: GO:0044707
+alt_id: GO:0050874
+def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]
+subset: goslim_pir
+synonym: "organismal physiological process" EXACT []
+synonym: "single-multicellular organism process" RELATED []
 is_a: GO:0008150 ! biological_process
+created_by: jl
+creation_date: 2012-09-19T16:07:47Z
 
 [Term]
 id: GO:0032502
@@ -32848,6 +33338,8 @@ is_a: GO:0008150 ! biological_process
 [Term]
 id: GO:0032504
 name: multicellular organism reproduction
+namespace: biological_process
+def: "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
 is_a: GO:0000003 ! reproduction
 is_a: GO:0032501 ! multicellular organismal process
 
@@ -32875,6 +33367,9 @@ relationship: part_of GO:0030425 ! dendrite
 [Term]
 id: GO:0032879
 name: regulation of localization
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]
+synonym: "regulation of localisation" EXACT [GOC:mah]
 is_a: GO:0050789 ! regulation of biological process
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0051179 ! localization
@@ -33265,11 +33760,18 @@ relationship: regulates GO:0040007 ! growth
 [Term]
 id: GO:0040011
 name: locomotion
+namespace: biological_process
+def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
+subset: goslim_chembl
+subset: goslim_generic
+subset: goslim_pir
 is_a: GO:0008150 ! biological_process
 
 [Term]
 id: GO:0040012
 name: regulation of locomotion
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]
 is_a: GO:0050789 ! regulation of biological process
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0040011 ! locomotion
@@ -33394,6 +33896,18 @@ is_a: GO:1901576 ! organic substance biosynthetic process
 [Term]
 id: GO:0042221
 name: response to chemical
+namespace: biological_process
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]
+comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
+subset: gocheck_do_not_manually_annotate
+subset: goslim_aspergillus
+subset: goslim_candida
+subset: goslim_drosophila
+subset: goslim_metagenomics
+subset: goslim_plant
+subset: goslim_yeast
+synonym: "response to chemical stimulus" EXACT [GOC:dos]
+synonym: "response to chemical substance" EXACT []
 is_a: GO:0050896 ! response to stimulus
 
 [Term]
@@ -33496,17 +34010,23 @@ relationship: part_of GO:0007320 ! insemination
 [Term]
 id: GO:0042745
 name: circadian sleep/wake cycle
+namespace: biological_process
+def: "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com]
 is_a: GO:0048512 ! circadian behavior
 
 [Term]
 id: GO:0042748
 name: circadian sleep/wake cycle, non-REM sleep
+namespace: biological_process
+def: "All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions." [GOC:jl, http://www.sleepquest.com]
 is_a: GO:0022410 ! circadian sleep/wake cycle process
 relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep
 
 [Term]
 id: GO:0042749
 name: regulation of circadian sleep/wake cycle
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." [GOC:jl]
 is_a: GO:0042752 ! regulation of circadian rhythm
 is_a: GO:0050795 ! regulation of behavior
 is_a: GO:0051239 ! regulation of multicellular organismal process
@@ -33517,6 +34037,8 @@ relationship: regulates GO:0042745 ! circadian sleep/wake cycle
 [Term]
 id: GO:0042752
 name: regulation of circadian rhythm
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]
 is_a: GO:0050789 ! regulation of biological process
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0007623 ! circadian rhythm
@@ -33788,6 +34310,8 @@ is_a: GO:0019236 ! response to pheromone
 [Term]
 id: GO:0043900
 name: regulation of multi-organism process
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl]
 is_a: GO:0050789 ! regulation of biological process
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0051704 ! multi-organism process
@@ -33801,6 +34325,8 @@ is_a: GO:0005976 ! polysaccharide metabolic process
 [Term]
 id: GO:0044057
 name: regulation of system process
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl]
 is_a: GO:0051239 ! regulation of multicellular organismal process
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0003008 ! system process
@@ -33825,6 +34351,8 @@ relationship: regulates GO:0050886 ! endocrine process
 [Term]
 id: GO:0044062
 name: regulation of excretion
+namespace: biological_process
+def: "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." [GOC:jl]
 is_a: GO:0044057 ! regulation of system process
 is_a: GO:0051046 ! regulation of secretion
 intersection_of: GO:0065007 ! biological regulation
@@ -33957,8 +34485,12 @@ is_a: GO:0030424 ! axon
 [Term]
 id: GO:0044703
 name: multi-organism reproductive process
+namespace: biological_process
+def: "A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl]
 is_a: GO:0022414 ! reproductive process
 is_a: GO:0051704 ! multi-organism process
+created_by: jl
+creation_date: 2012-09-19T15:56:30Z
 
 [Term]
 id: GO:0044706
@@ -34003,6 +34535,9 @@ is_a: GO:0051234 ! establishment of localization
 [Term]
 id: GO:0045187
 name: regulation of circadian sleep/wake cycle, sleep
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981]
+synonym: "regulation of sleep" EXACT []
 is_a: GO:0042749 ! regulation of circadian sleep/wake cycle
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0050802 ! circadian sleep/wake cycle, sleep
@@ -34011,6 +34546,9 @@ relationship: regulates GO:0050802 ! circadian sleep/wake cycle, sleep
 [Term]
 id: GO:0045188
 name: regulation of circadian sleep/wake cycle, non-REM sleep
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep." [GOC:go_curators]
+synonym: "regulation of non-REM sleep" EXACT []
 is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep
@@ -34797,6 +35335,9 @@ relationship: regulates GO:0008610 ! lipid biosynthetic process
 [Term]
 id: GO:0046903
 name: secretion
+namespace: biological_process
+def: "The controlled release of a substance by a cell or a tissue." [GOC:ai]
+subset: goslim_pir
 is_a: GO:0006810 ! transport
 
 [Term]
@@ -34863,11 +35404,18 @@ is_a: GO:0007292 ! female gamete generation
 [Term]
 id: GO:0048511
 name: rhythmic process
+namespace: biological_process
+def: "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid]
+subset: goslim_pir
+synonym: "rhythm" RELATED []
 is_a: GO:0008150 ! biological_process
 
 [Term]
 id: GO:0048512
 name: circadian behavior
+namespace: biological_process
+def: "The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr]
+synonym: "circadian rhythm behavior" EXACT []
 is_a: GO:0007622 ! rhythmic behavior
 is_a: GO:0007623 ! circadian rhythm
 
@@ -34980,6 +35528,10 @@ relationship: positively_regulates GO:0009791 ! post-embryonic development
 [Term]
 id: GO:0048583
 name: regulation of response to stimulus
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
+comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
+subset: gocheck_do_not_manually_annotate
 is_a: GO:0050789 ! regulation of biological process
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0050896 ! response to stimulus
@@ -35032,6 +35584,10 @@ relationship: part_of GO:0061458 ! reproductive system development
 [Term]
 id: GO:0048609
 name: multicellular organismal reproductive process
+namespace: biological_process
+def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb]
+synonym: "organismal reproductive process" BROAD []
+synonym: "reproductive process in a multicellular organism" EXACT []
 is_a: GO:0022414 ! reproductive process
 relationship: part_of GO:0032504 ! multicellular organism reproduction
 
@@ -35334,6 +35890,14 @@ relationship: positively_regulates GO:0006955 ! immune response
 [Term]
 id: GO:0050789
 name: regulation of biological process
+namespace: biological_process
+alt_id: GO:0050791
+def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]
+subset: gocheck_do_not_annotate
+subset: goslim_aspergillus
+subset: goslim_candida
+subset: goslim_pir
+synonym: "regulation of physiological process" EXACT []
 is_a: GO:0065007 ! biological regulation
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0008150 ! biological_process
@@ -35358,6 +35922,9 @@ relationship: regulates GO:0009987 ! cellular process
 [Term]
 id: GO:0050795
 name: regulation of behavior
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr]
+synonym: "regulation of behaviour" EXACT []
 is_a: GO:0048583 ! regulation of response to stimulus
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0007610 ! behavior
@@ -35380,6 +35947,8 @@ is_a: GO:0048878 ! chemical homeostasis
 [Term]
 id: GO:0050802
 name: circadian sleep/wake cycle, sleep
+namespace: biological_process
+def: "The part of the circadian sleep/wake cycle where the organism is asleep." [GOC:ai]
 is_a: GO:0022410 ! circadian sleep/wake cycle process
 is_a: GO:0030431 ! sleep
 intersection_of: GO:0030431 ! sleep
@@ -35509,6 +36078,16 @@ relationship: positively_regulates GO:0042113 ! B cell activation
 [Term]
 id: GO:0050877
 name: nervous system process
+namespace: biological_process
+def: "A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]
+subset: goslim_agr
+subset: goslim_chembl
+subset: goslim_flybase_ribbon
+subset: goslim_generic
+subset: goslim_pir
+synonym: "neurological system process" EXACT []
+synonym: "neurophysiological process" EXACT []
+synonym: "pan-neural process" RELATED []
 is_a: GO:0003008 ! system process
 
 [Term]
@@ -35536,6 +36115,9 @@ relationship: has_part GO:0050881 ! musculoskeletal movement
 [Term]
 id: GO:0050885
 name: neuromuscular process controlling balance
+namespace: biological_process
+def: "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors." [GOC:ai, GOC:dph]
+synonym: "regulation of balance" RELATED []
 is_a: GO:0050905 ! neuromuscular process
 relationship: has_part GO:0050881 ! musculoskeletal movement
 
@@ -35559,16 +36141,37 @@ is_a: GO:0050878 ! regulation of body fluid levels
 [Term]
 id: GO:0050896
 name: response to stimulus
+namespace: biological_process
+alt_id: GO:0051869
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
+comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
+subset: gocheck_do_not_manually_annotate
+subset: goslim_agr
+subset: goslim_flybase_ribbon
+subset: goslim_mouse
+subset: goslim_pir
+synonym: "physiological response to stimulus" EXACT []
 is_a: GO:0008150 ! biological_process
 
 [Term]
 id: GO:0050905
 name: neuromuscular process
+namespace: biological_process
+def: "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai]
+synonym: "neuromotor process" EXACT []
+synonym: "neuromuscular physiological process" EXACT []
 is_a: GO:0050877 ! nervous system process
 
 [Term]
 id: GO:0050906
 name: detection of stimulus involved in sensory perception
+namespace: biological_process
+def: "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph]
+synonym: "sensory detection of stimulus" EXACT []
+synonym: "sensory perception, sensory transduction of stimulus" EXACT []
+synonym: "sensory perception, stimulus detection" EXACT []
+synonym: "sensory transduction" EXACT []
+xref: Wikipedia:Transduction_(physiology)
 is_a: GO:0051606 ! detection of stimulus
 intersection_of: GO:0051606 ! detection of stimulus
 intersection_of: part_of GO:0007600 ! sensory perception
@@ -35577,6 +36180,14 @@ relationship: part_of GO:0007600 ! sensory perception
 [Term]
 id: GO:0050907
 name: detection of chemical stimulus involved in sensory perception
+namespace: biological_process
+def: "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
+synonym: "sensory detection of chemical stimulus" EXACT []
+synonym: "sensory detection of chemical stimulus during sensory perception" EXACT []
+synonym: "sensory perception, sensory detection of chemical stimulus" EXACT []
+synonym: "sensory perception, sensory transduction of chemical stimulus" EXACT []
+synonym: "sensory transduction of chemical stimulus" EXACT []
+synonym: "sensory transduction of chemical stimulus during sensory perception" EXACT []
 is_a: GO:0009593 ! detection of chemical stimulus
 is_a: GO:0050906 ! detection of stimulus involved in sensory perception
 intersection_of: GO:0009593 ! detection of chemical stimulus
@@ -35596,11 +36207,30 @@ relationship: part_of GO:0007601 ! visual perception
 [Term]
 id: GO:0050909
 name: sensory perception of taste
+namespace: biological_process
+def: "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai]
+synonym: "gustation" EXACT []
+synonym: "sense of taste" EXACT []
+synonym: "taste" EXACT []
+synonym: "taste perception" EXACT []
+xref: Wikipedia:Taste
 is_a: GO:0007606 ! sensory perception of chemical stimulus
 
 [Term]
 id: GO:0050910
 name: detection of mechanical stimulus involved in sensory perception of sound
+namespace: biological_process
+alt_id: GO:0009592
+alt_id: GO:0055128
+def: "The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal." [GOC:ai]
+synonym: "detection of sound" EXACT []
+synonym: "hearing, sensory transduction of sound" EXACT []
+synonym: "perception of sound, detection of mechanical stimulus" EXACT []
+synonym: "perception of sound, sensory detection of mechanical stimulus" EXACT []
+synonym: "perception of sound, sensory transduction of mechanical stimulus" EXACT []
+synonym: "sensory detection of mechanical stimulus during perception of sound" EXACT []
+synonym: "sensory transduction of mechanical stimulus during perception of sound" EXACT []
+synonym: "sensory transduction of sound" EXACT []
 is_a: GO:0050877 ! nervous system process
 is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
 intersection_of: GO:0050982 ! detection of mechanical stimulus
@@ -35610,6 +36240,17 @@ relationship: part_of GO:0007605 ! sensory perception of sound
 [Term]
 id: GO:0050911
 name: detection of chemical stimulus involved in sensory perception of smell
+namespace: biological_process
+def: "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
+synonym: "perception of smell, detection of chemical stimulus" EXACT []
+synonym: "perception of smell, sensory detection of chemical stimulus" EXACT []
+synonym: "perception of smell, sensory transduction of chemical stimulus" EXACT []
+synonym: "sensory detection of chemical stimulus during perception of smell" EXACT []
+synonym: "sensory detection of scent" EXACT []
+synonym: "sensory detection of smell" EXACT []
+synonym: "sensory transduction of chemical stimulus during perception of smell" EXACT []
+synonym: "sensory transduction of scent" EXACT []
+synonym: "sensory transduction of smell" EXACT []
 is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
 intersection_of: GO:0009593 ! detection of chemical stimulus
 intersection_of: part_of GO:0007608 ! sensory perception of smell
@@ -35618,6 +36259,16 @@ relationship: part_of GO:0007608 ! sensory perception of smell
 [Term]
 id: GO:0050912
 name: detection of chemical stimulus involved in sensory perception of taste
+namespace: biological_process
+def: "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
+synonym: "perception of taste, detection of chemical stimulus" EXACT []
+synonym: "perception of taste, sensory detection of chemical stimulus" EXACT []
+synonym: "perception of taste, sensory transduction of chemical stimulus" EXACT []
+synonym: "sensory detection of chemical stimulus during perception of taste" EXACT []
+synonym: "sensory detection of taste" EXACT []
+synonym: "sensory transduction of chemical stimulus during perception of taste" EXACT []
+synonym: "sensory transduction of taste" EXACT []
+synonym: "taste perception" BROAD []
 is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
 intersection_of: GO:0009593 ! detection of chemical stimulus
 intersection_of: part_of GO:0050909 ! sensory perception of taste
@@ -35626,6 +36277,9 @@ relationship: part_of GO:0050909 ! sensory perception of taste
 [Term]
 id: GO:0050951
 name: sensory perception of temperature stimulus
+namespace: biological_process
+def: "The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
+synonym: "sensory perception of thermal stimulus" EXACT []
 is_a: GO:0007600 ! sensory perception
 
 [Term]
@@ -35636,11 +36290,18 @@ is_a: GO:0007600 ! sensory perception
 [Term]
 id: GO:0050953
 name: sensory perception of light stimulus
+namespace: biological_process
+def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
 is_a: GO:0007600 ! sensory perception
 
 [Term]
 id: GO:0050954
 name: sensory perception of mechanical stimulus
+namespace: biological_process
+def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
+synonym: "chemi-mechanical coupling" RELATED []
+synonym: "mechanosensory perception" EXACT []
+synonym: "perception of mechanical stimulus" EXACT []
 is_a: GO:0007600 ! sensory perception
 
 [Term]
@@ -35651,6 +36312,10 @@ is_a: GO:0050952 ! sensory perception of electrical stimulus
 [Term]
 id: GO:0050957
 name: equilibrioception
+namespace: biological_process
+def: "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion." [http://www.medterms.com]
+synonym: "sensory perception of orientation with respect to gravity" EXACT []
+xref: Wikipedia:Equilibrioception
 is_a: GO:0007600 ! sensory perception
 relationship: part_of GO:0050885 ! neuromuscular process controlling balance
 
@@ -35662,6 +36327,22 @@ is_a: GO:0050877 ! nervous system process
 [Term]
 id: GO:0050961
 name: detection of temperature stimulus involved in sensory perception
+namespace: biological_process
+def: "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
+synonym: "sensory detection of heat stimulus during sensory perception" NARROW []
+synonym: "sensory detection of temperature stimulus" EXACT []
+synonym: "sensory detection of temperature stimulus during sensory perception" EXACT []
+synonym: "sensory detection of thermal stimulus during sensory perception" EXACT []
+synonym: "sensory perception, sensory detection of heat stimulus" NARROW []
+synonym: "sensory perception, sensory detection of temperature stimulus" EXACT []
+synonym: "sensory perception, sensory detection of thermal stimulus" EXACT []
+synonym: "sensory perception, sensory transduction of heat stimulus" NARROW []
+synonym: "sensory perception, sensory transduction of temperature stimulus" EXACT []
+synonym: "sensory perception, sensory transduction of thermal stimulus" EXACT []
+synonym: "sensory transduction of heat stimulus during sensory perception" NARROW []
+synonym: "sensory transduction of temperature stimulus" EXACT []
+synonym: "sensory transduction of temperature stimulus during sensory perception" EXACT []
+synonym: "sensory transduction of thermal stimulus during sensory perception" EXACT []
 is_a: GO:0016048 ! detection of temperature stimulus
 is_a: GO:0050906 ! detection of stimulus involved in sensory perception
 intersection_of: GO:0016048 ! detection of temperature stimulus
@@ -35700,6 +36381,18 @@ relationship: part_of GO:0050956 ! electroception
 [Term]
 id: GO:0050965
 name: detection of temperature stimulus involved in sensory perception of pain
+namespace: biological_process
+def: "The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
+synonym: "perception of pain, detection of temperature stimulus" EXACT []
+synonym: "perception of pain, sensory detection of temperature stimulus" EXACT []
+synonym: "perception of pain, sensory transduction of temperature stimulus" EXACT []
+synonym: "sensory detection of temperature stimulus during perception of pain" EXACT []
+synonym: "sensory detection of thermal stimulus during sensory perception of pain" EXACT []
+synonym: "sensory perception of pain, sensory detection of thermal stimulus" EXACT []
+synonym: "sensory perception of pain, sensory transduction of thermal stimulus" EXACT []
+synonym: "sensory transduction of temperature stimulus during perception of pain" EXACT []
+synonym: "sensory transduction of thermal stimulus during sensory perception of pain" EXACT []
+synonym: "thermal nociception" RELATED [GOC:pr]
 is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception
 is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain
 intersection_of: GO:0016048 ! detection of temperature stimulus
@@ -35709,6 +36402,14 @@ relationship: part_of GO:0019233 ! sensory perception of pain
 [Term]
 id: GO:0050966
 name: detection of mechanical stimulus involved in sensory perception of pain
+namespace: biological_process
+def: "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
+synonym: "mechanical nociception" RELATED [GOC:pr]
+synonym: "perception of pain, detection of mechanical stimulus" EXACT []
+synonym: "perception of pain, sensory detection of mechanical stimulus" EXACT []
+synonym: "perception of pain, sensory transduction of mechanical stimulus" EXACT []
+synonym: "sensory detection of mechanical stimulus during perception of pain" EXACT []
+synonym: "sensory transduction of mechanical stimulus during perception of pain" EXACT []
 is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
 is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain
 intersection_of: GO:0050982 ! detection of mechanical stimulus
@@ -35727,6 +36428,14 @@ relationship: part_of GO:0019233 ! sensory perception of pain
 [Term]
 id: GO:0050968
 name: detection of chemical stimulus involved in sensory perception of pain
+namespace: biological_process
+def: "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal." [GOC:ai]
+synonym: "chemical nociception" RELATED [GOC:pr]
+synonym: "perception of pain, detection of chemical stimulus" EXACT []
+synonym: "perception of pain, sensory detection of chemical stimulus" EXACT []
+synonym: "perception of pain, sensory transduction of chemical stimulus" EXACT []
+synonym: "sensory detection of chemical stimulus during perception of pain" EXACT []
+synonym: "sensory transduction of chemical stimulus during perception of pain" EXACT []
 is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
 is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain
 intersection_of: GO:0009593 ! detection of chemical stimulus
@@ -35744,6 +36453,13 @@ relationship: part_of GO:0050959 ! echolocation
 [Term]
 id: GO:0050973
 name: detection of mechanical stimulus involved in equilibrioception
+namespace: biological_process
+def: "The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears." [GOC:ai, GOC:dos]
+synonym: "equilibrioception, detection of mechanical stimulus" EXACT []
+synonym: "equilibrioception, sensory detection of mechanical stimulus" EXACT []
+synonym: "equilibrioception, sensory transduction of mechanical stimulus" EXACT []
+synonym: "sensory detection of mechanical stimulus during equilibrioception" EXACT []
+synonym: "sensory transduction of mechanical stimulus during equilibrioception" EXACT []
 is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
 intersection_of: GO:0050982 ! detection of mechanical stimulus
 intersection_of: part_of GO:0050957 ! equilibrioception
@@ -35752,6 +36468,14 @@ relationship: part_of GO:0050957 ! equilibrioception
 [Term]
 id: GO:0050974
 name: detection of mechanical stimulus involved in sensory perception
+namespace: biological_process
+def: "The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
+synonym: "sensory detection of mechanical stimulus" EXACT []
+synonym: "sensory detection of mechanical stimulus during sensory perception" EXACT []
+synonym: "sensory perception, sensory detection of mechanical stimulus" EXACT []
+synonym: "sensory perception, sensory transduction of mechanical stimulus" EXACT []
+synonym: "sensory transduction of mechanical stimulus" EXACT []
+synonym: "sensory transduction of mechanical stimulus during sensory perception" EXACT []
 is_a: GO:0050906 ! detection of stimulus involved in sensory perception
 is_a: GO:0050982 ! detection of mechanical stimulus
 intersection_of: GO:0050982 ! detection of mechanical stimulus
@@ -35762,11 +36486,26 @@ relationship: part_of GO:0050954 ! sensory perception of mechanical stimulus
 [Term]
 id: GO:0050975
 name: sensory perception of touch
+namespace: biological_process
+def: "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
+synonym: "perception of touch" EXACT []
+synonym: "tactile sense" EXACT []
+synonym: "taction" EXACT []
+synonym: "tactition" EXACT []
+xref: Wikipedia:Touch
 is_a: GO:0050954 ! sensory perception of mechanical stimulus
 
 [Term]
 id: GO:0050976
 name: detection of mechanical stimulus involved in sensory perception of touch
+namespace: biological_process
+def: "The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
+synonym: "perception of touch, detection of mechanical stimulus" EXACT []
+synonym: "perception of touch, sensory detection of mechanical stimulus" EXACT []
+synonym: "perception of touch, sensory transduction of mechanical stimulus" EXACT []
+synonym: "sensory detection of mechanical stimulus during perception of touch" EXACT []
+synonym: "sensory transduction of mechanical stimulus during perception of touch" EXACT []
+synonym: "tactition, sensory detection of mechanical stimulus" EXACT []
 is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
 intersection_of: GO:0050982 ! detection of mechanical stimulus
 intersection_of: part_of GO:0050975 ! sensory perception of touch
@@ -35781,6 +36520,8 @@ is_a: GO:0051602 ! response to electrical stimulus
 [Term]
 id: GO:0050982
 name: detection of mechanical stimulus
+namespace: biological_process
+def: "The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
 is_a: GO:0009581 ! detection of external stimulus
 is_a: GO:0009582 ! detection of abiotic stimulus
 is_a: GO:0009612 ! response to mechanical stimulus
@@ -35788,6 +36529,8 @@ is_a: GO:0009612 ! response to mechanical stimulus
 [Term]
 id: GO:0051046
 name: regulation of secretion
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
 is_a: GO:0051049 ! regulation of transport
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0046903 ! secretion
@@ -35814,6 +36557,9 @@ relationship: negatively_regulates GO:0046903 ! secretion
 [Term]
 id: GO:0051049
 name: regulation of transport
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
+subset: goslim_yeast
 is_a: GO:0032879 ! regulation of localization
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0006810 ! transport
@@ -35920,7 +36666,21 @@ relationship: positively_regulates GO:0006807 ! nitrogen compound metabolic proc
 [Term]
 id: GO:0051179
 name: localization
+namespace: biological_process
+alt_id: GO:1902578
+def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]
+subset: goslim_pir
+synonym: "establishment and maintenance of cellular component location" NARROW []
+synonym: "establishment and maintenance of localization" EXACT []
+synonym: "establishment and maintenance of position" EXACT []
+synonym: "establishment and maintenance of substance location" NARROW []
+synonym: "establishment and maintenance of substrate location" NARROW []
+synonym: "localisation" EXACT [GOC:mah]
+synonym: "single organism localization" RELATED [GOC:TermGenie]
+synonym: "single-organism localization" RELATED []
 is_a: GO:0008150 ! biological_process
+created_by: jl
+creation_date: 2013-12-18T13:51:04Z
 
 [Term]
 id: GO:0051216
@@ -35961,11 +36721,20 @@ relationship: negatively_regulates GO:0015031 ! protein transport
 [Term]
 id: GO:0051234
 name: establishment of localization
+namespace: biological_process
+def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]
+subset: goslim_agr
+subset: goslim_flybase_ribbon
+subset: goslim_mouse
+subset: goslim_pir
+synonym: "establishment of localisation" EXACT [GOC:mah]
 is_a: GO:0051179 ! localization
 
 [Term]
 id: GO:0051239
 name: regulation of multicellular organismal process
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]
 is_a: GO:0050789 ! regulation of biological process
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0032501 ! multicellular organismal process
@@ -36075,6 +36844,11 @@ relationship: part_of GO:0050957 ! equilibrioception
 [Term]
 id: GO:0051356
 name: visual perception involved in equilibrioception
+namespace: biological_process
+def: "The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai]
+synonym: "equilibrioception by visual perception" NARROW []
+synonym: "perception of orientation with respect to gravity by visual perception" EXACT []
+synonym: "visual perception during equilibrioception" RELATED [GOC:dph, GOC:tb]
 is_a: GO:0007601 ! visual perception
 intersection_of: GO:0007601 ! visual perception
 intersection_of: part_of GO:0050957 ! equilibrioception
@@ -36117,6 +36891,12 @@ is_a: GO:0009628 ! response to abiotic stimulus
 [Term]
 id: GO:0051606
 name: detection of stimulus
+namespace: biological_process
+def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah]
+subset: goslim_pir
+synonym: "perception of stimulus" RELATED []
+synonym: "stimulus detection" EXACT []
+synonym: "stimulus sensing" RELATED []
 is_a: GO:0050896 ! response to stimulus
 
 [Term]
@@ -36128,6 +36908,14 @@ is_a: GO:0051179 ! localization
 [Term]
 id: GO:0051704
 name: multi-organism process
+namespace: biological_process
+alt_id: GO:0051706
+def: "A biological process which involves another organism of the same or different species." [GOC:jl]
+subset: gocheck_do_not_annotate
+subset: goslim_pir
+synonym: "interaction between organisms" EXACT []
+synonym: "physiological interaction between organisms" EXACT []
+synonym: "physiological interaction with other organism" EXACT []
 is_a: GO:0008150 ! biological_process
 
 [Term]
@@ -36191,6 +36979,8 @@ relationship: positively_regulates GO:0000280 ! nuclear division
 [Term]
 id: GO:0051930
 name: regulation of sensory perception of pain
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai]
 is_a: GO:0051931 ! regulation of sensory perception
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0019233 ! sensory perception of pain
@@ -36199,6 +36989,8 @@ relationship: regulates GO:0019233 ! sensory perception of pain
 [Term]
 id: GO:0051931
 name: regulation of sensory perception
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai]
 is_a: GO:0031644 ! regulation of nervous system process
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0007600 ! sensory perception
@@ -36330,6 +37122,9 @@ relationship: part_of GO:0007605 ! sensory perception of sound
 [Term]
 id: GO:0060004
 name: reflex
+namespace: biological_process
+def: "An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness." [GOC:dph, ISBN:0877797099]
+xref: Wikipedia:Reflex
 is_a: GO:0009605 ! response to external stimulus
 
 [Term]
@@ -36373,6 +37168,11 @@ relationship: part_of GO:0042060 ! wound healing
 [Term]
 id: GO:0060073
 name: micturition
+namespace: biological_process
+def: "The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body." [GOC:dph]
+synonym: "urination" EXACT []
+synonym: "urine voiding" EXACT []
+xref: Wikipedia:Urination
 is_a: GO:0003014 ! renal system process
 is_a: GO:0007588 ! excretion
 
@@ -36434,6 +37234,9 @@ relationship: regulates GO:0043170 ! macromolecule metabolic process
 [Term]
 id: GO:0060259
 name: regulation of feeding behavior
+namespace: biological_process
+def: "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:BHF, GOC:dph, GOC:tb]
+synonym: "regulation of feeding behaviour" EXACT [GOC:dph, GOC:tb]
 is_a: GO:0050795 ! regulation of behavior
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0007631 ! feeding behavior
@@ -36818,19 +37621,33 @@ is_a: GO:0031012 ! extracellular matrix
 [Term]
 id: GO:0062149
 name: detection of stimulus involved in sensory perception of pain
+namespace: biological_process
+def: "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal." [PMID:19837031]
 is_a: GO:0050906 ! detection of stimulus involved in sensory perception
 intersection_of: GO:0051606 ! detection of stimulus
 intersection_of: part_of GO:0019233 ! sensory perception of pain
 relationship: part_of GO:0019233 ! sensory perception of pain
+created_by: dph
+creation_date: 2019-09-13T13:48:47Z
 
 [Term]
 id: GO:0065007
 name: biological regulation
+namespace: biological_process
+def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
+subset: gocheck_do_not_annotate
+subset: goslim_pir
+synonym: "regulation" BROAD []
 is_a: GO:0008150 ! biological_process
 
 [Term]
 id: GO:0065008
 name: regulation of biological quality
+namespace: biological_process
+def: "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
+subset: goslim_pir
+synonym: "regulation of biological attribute" EXACT []
+synonym: "regulation of biological characteristic" EXACT []
 is_a: GO:0065007 ! biological regulation
 
 [Term]
@@ -37209,10 +38026,16 @@ relationship: regulates GO:0044238 ! primary metabolic process
 [Term]
 id: GO:0080134
 name: regulation of response to stress
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]
+comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
+subset: gocheck_do_not_manually_annotate
 is_a: GO:0048583 ! regulation of response to stimulus
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0006950 ! response to stress
 relationship: regulates GO:0006950 ! response to stress
+created_by: dhl
+creation_date: 2009-05-06T04:51:28Z
 
 [Term]
 id: GO:0090030
@@ -37332,11 +38155,15 @@ relationship: positively_regulates GO:0042060 ! wound healing
 [Term]
 id: GO:0090325
 name: regulation of locomotion involved in locomotory behavior
+namespace: biological_process
+def: "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb]
 is_a: GO:0040012 ! regulation of locomotion
 is_a: GO:0050795 ! regulation of behavior
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0031987 ! locomotion involved in locomotory behavior
 relationship: regulates GO:0031987 ! locomotion involved in locomotory behavior
+created_by: tb
+creation_date: 2010-05-14T10:24:29Z
 
 [Term]
 id: GO:0090326
@@ -37556,6 +38383,8 @@ relationship: part_of GO:0005886 ! plasma membrane
 [Term]
 id: GO:0098801
 name: regulation of renal system process
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system." [GOC:dos]
 is_a: GO:0044057 ! regulation of system process
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0003014 ! renal system process
@@ -37946,7 +38775,12 @@ is_a: GO:1901615 ! organic hydroxy compound metabolic process
 [Term]
 id: GO:1901700
 name: response to oxygen-containing compound
+namespace: biological_process
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]
+synonym: "response to oxygen molecular entity" EXACT []
 is_a: GO:0042221 ! response to chemical
+created_by: pr
+creation_date: 2012-12-13T15:11:37Z
 
 [Term]
 id: GO:1902019
@@ -38674,11 +39508,21 @@ relationship: negatively_regulates GO:0046541 ! saliva secretion
 [Term]
 id: GO:1905787
 name: regulation of detection of mechanical stimulus involved in sensory perception of touch
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." [GO_REF:0000058, GOC:TermGenie, PMID:8692859]
+synonym: "regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie]
+synonym: "regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
+synonym: "regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie]
+synonym: "regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
+synonym: "regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
+synonym: "regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
 is_a: GO:0032101 ! regulation of response to external stimulus
 is_a: GO:0051931 ! regulation of sensory perception
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch
 relationship: regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch
+created_by: hbye
+creation_date: 2017-01-09T15:11:04Z
 
 [Term]
 id: GO:1905788
@@ -38848,10 +39692,18 @@ relationship: regulates GO:0017145 ! stem cell division
 [Term]
 id: GO:2000070
 name: regulation of response to water deprivation
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of response to water deprivation." [GOC:obol]
+synonym: "regulation of drought tolerance" RELATED [GOC:obol]
+synonym: "regulation of response to dehydration" EXACT [GOC:obol]
+synonym: "regulation of response to drought" EXACT [GOC:obol]
+synonym: "regulation of response to thirst" EXACT [GOC:obol]
 is_a: GO:0080134 ! regulation of response to stress
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0009414 ! response to water deprivation
 relationship: regulates GO:0009414 ! response to water deprivation
+created_by: tb
+creation_date: 2010-08-23T11:32:32Z
 
 [Term]
 id: GO:2000112
@@ -38975,10 +39827,14 @@ relationship: positively_regulates GO:0006536 ! glutamate metabolic process
 [Term]
 id: GO:2000241
 name: regulation of reproductive process
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah]
 is_a: GO:0050789 ! regulation of biological process
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0022414 ! reproductive process
 relationship: regulates GO:0022414 ! reproductive process
+created_by: mah
+creation_date: 2010-11-10T02:44:02Z
 
 [Term]
 id: GO:2000242
@@ -39037,10 +39893,14 @@ relationship: positively_regulates GO:0038023 ! signaling receptor activity
 [Term]
 id: GO:2000292
 name: regulation of defecation
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of defecation." [GOC:obol]
 is_a: GO:0044062 ! regulation of excretion
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0030421 ! defecation
 relationship: regulates GO:0030421 ! defecation
+created_by: bf
+creation_date: 2010-12-21T09:23:08Z
 
 [Term]
 id: GO:2000293
@@ -39167,10 +40027,15 @@ relationship: positively_regulates GO:0006590 ! thyroid hormone generation
 [Term]
 id: GO:2000821
 name: regulation of grooming behavior
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of grooming behavior." [GOC:BHF]
+synonym: "regulation of grooming behaviour" EXACT [GOC:obol]
 is_a: GO:0050795 ! regulation of behavior
 intersection_of: GO:0065007 ! biological regulation
 intersection_of: regulates GO:0007625 ! grooming behavior
 relationship: regulates GO:0007625 ! grooming behavior
+created_by: rl
+creation_date: 2011-07-14T04:48:12Z
 
 [Term]
 id: GO:2000828
@@ -39373,189 +40238,328 @@ relationship: positively_regulates GO:0003097 ! renal water transport
 [Term]
 id: NBO:0000001
 name: body part movement
+namespace: behavior_ontology
+def: "A change of place or position of part of an organism that does not involve the entire organism [NBO:SMAC]" []
+synonym: "stationary movement" EXACT []
 is_a: NBO:0000338 ! kinesthetic behavior
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000007
 name: mouth movement
+namespace: behavior_ontology
+def: "The act of moving any of the tissues and hard structures surrounding the mouth other than teeth, jaws or filter structures [NBO:AC]" []
+synonym: "mouth part movement" NARROW []
+synonym: "other moved mouth parts" NARROW []
 is_a: NBO:0000001 ! body part movement
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000027
 name: grooming behavior
+namespace: behavior_ontology
+def: "The act of using body parts to pick at, rub and or remove material from exterior covering, e.g., fur, scales, feathers, skin [NBO:SMAC]" []
+synonym: "groom" EXACT []
+synonym: "grooming behaviour" EXACT []
+synonym: "hygiene" RELATED []
+xref: GO:0007625
 is_a: NBO:0000313 ! behavior process
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000063
 name: regulation of eating behavior
+namespace: behavior_ontology
+def: "\"A feeding behavior associated with the intake or the frequency of intake or preference or manner of intake of food.\" [NBO:GVG]" []
+synonym: "eating behaviour" EXACT []
+xref: GO:0042755
 is_a: NBO:0002436 ! regulation of feeding behavior
 relationship: regulates NBO:0000134 ! food consumption
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000064
 name: regulation of drinking behavior
+namespace: behavior_ontology
+def: "\"A feeding behavior associated with the intake or the frequency of intake or preference or manner of intake of liquids.\" [NBO:GVG]" []
+synonym: "drinking behaviour" EXACT []
+xref: GO:0042756
 is_a: NBO:0002436 ! regulation of feeding behavior
 relationship: regulates NBO:0000130 ! liquid consumption
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000073
 name: chewing
+namespace: behavior_ontology
+def: "The act of repeated grinding, tearing, and or crushing with teeth or jaws [NBO:SMAC]" []
+synonym: "chew" EXACT []
+synonym: "gnaw" EXACT []
+synonym: "mastication" EXACT []
 is_a: NBO:0000747 ! jaw movement
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000079
 name: feeding behavior
+namespace: behavior_ontology
+def: "The act of bringing an object or substance into the body by swallowing, surrounding or absorbing it [NBO:SMAC]" []
+synonym: "feeding behaviour" EXACT []
+xref: GO:0007631
 is_a: NBO:0001845 ! consumption behavior
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000130
 name: liquid consumption
+namespace: behavior_ontology
+def: "\"A behavior associated with the intake of liquid.\" [NBO:GVG]" []
 is_a: NBO:0000079 ! feeding behavior
 relationship: has_participant PATO:0001548 ! quality of a liquid
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000134
 name: food consumption
+namespace: behavior_ontology
+def: "\"A feeding behavior associated with the intake of food.\" [NBO:GVG]" []
 is_a: NBO:0000079 ! feeding behavior
 intersection_of: NBO:0000079 ! feeding behavior
 intersection_of: has_participant CHEBI:33290 ! food
 relationship: has_participant CHEBI:33290 ! food
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000308
 name: sensation behavior
+namespace: behavior_ontology
+alt_id: NBO:0000454
+def: "\"Cognitive perception of a sensation by any of the five senses -- vision, touch, smell, taste, and hearing.\" [NBO:GVG]" []
+comment: Example: moving head to watch passing object.
+synonym: "behavior involving perception" EXACT []
+synonym: "perception behavior" EXACT []
 is_a: NBO:0000607 ! cognitive behavior
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000313
 name: behavior process
+namespace: behavior_ontology
+alt_id: NBO:0000000
+def: "\"The action, reaction, or performance of an organism in response to external or internal stimuli.\" [GO:GO\\:0007610]" []
+synonym: "behavior" EXACT []
+synonym: "behaviour" EXACT []
+xref: GO:0007610
 is_a: GO:0007610 ! behavior
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000317
 name: vestibular behavior
+namespace: behavior_ontology
+def: "\"Behavior related to the awareness of body balance and movement.\" [MBP:GVG]" []
+synonym: "proprioception" EXACT []
 is_a: NBO:0000327 ! somatic sensation related behavior
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000327
 name: somatic sensation related behavior
+namespace: behavior_ontology
+def: "\"Behavior related to the sensations arising from the skin and from the muscles, tendons, and joints.\" [OBP:GVG]" []
+comment: Sensations arising from the internal organs (the viscera), such as pain or the sense of fullness of the stomach or bladder, may therefore be included, although they are usually considered separately as visceral sensations. Pain arising from the viscera is often felt as though it comes from some part of the body surface or underlying tissue.
 is_a: NBO:0000751 ! perception behavior by means
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000338
 name: kinesthetic behavior
+namespace: behavior_ontology
+def: "\"Movement behavior of the body or its parts.\"" []
 is_a: NBO:0000313 ! behavior process
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000339
 name: motor coordination
+namespace: behavior_ontology
+alt_id: NBO:0000340
+def: "\"The coordination of combinations of body movements created with the kinematic (such as spatial direction) and kinetic (force) parameters that result in intended actions.\" [wikipedia:Motor_coordination]" []
 is_a: NBO:0000317 ! vestibular behavior
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000342
 name: limb coordination
+namespace: behavior_ontology
+def: "\"The coordination of limb movement.\" [NBO:GVG]" []
 is_a: NBO:0000347 ! gross motor coordination
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000347
 name: gross motor coordination
+namespace: behavior_ontology
+def: "\"The coordination of large muscle groups and whole body movement.\" [NBO:GVG]" []
+synonym: "large muscle coordination" EXACT []
+synonym: "whole body coordination" EXACT []
 is_a: NBO:0000339 ! motor coordination
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000355
 name: posture
+namespace: behavior_ontology
+def: "\"Intentionally or habitually assumed arrangement of the body and its limbs.\" [NBO:GVG]" []
 is_a: NBO:0000317 ! vestibular behavior
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000356
 name: body posture
+namespace: behavior_ontology
+def: "\"Intentionally or habitually assumed arrangement of the body.\" [NBO:GVG]" []
 is_a: NBO:0000355 ! posture
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000357
 name: limb posture
+namespace: behavior_ontology
+def: "\"Intentionally or habitually assumed arrangement of the limbs.\" [NBO:GVG]" []
 is_a: NBO:0000355 ! posture
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000361
 name: gait
+namespace: behavior_ontology
+def: "\"The pattern of movement of the limbs of animals, characterized by elements of progression, stability, speed and length over the ground.\" [MP:0001406]" []
 is_a: NBO:0000342 ! limb coordination
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000388
 name: involuntary movement behavior
+namespace: behavior_ontology
+def: "\"Behavior related to movements that occur independent of planning.\" [NBO:GVG]" []
+comment: Movevents listed here are involuntary, but may be also generated by free will, like blinking of the eyelids and respiratory movements.
 is_a: NBO:0000001 ! body part movement
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000389
 name: reflexive behavior
+namespace: behavior_ontology
+alt_id: NBO:0000004
+def: "\"Behavior related to involuntary movement in response to a stimulus.\" [NBO:GVG]" []
+synonym: "reflex behaviour" EXACT []
 is_a: NBO:0000388 ! involuntary movement behavior
 intersection_of: NBO:0000388 ! involuntary movement behavior
 intersection_of: by_means GO:0060004 ! reflex
 relationship: by_means GO:0060004 ! reflex
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000411
 name: cranial nerve related reflex
+namespace: behavior_ontology
+def: "\"A reflex that involves cranial nerves.\" [wikipedia:Reflex]" []
 is_a: NBO:0000389 ! reflexive behavior
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000412
 name: pupillary light reflex
+namespace: behavior_ontology
+def: "\"A reflex that controls the diameter of the pupil, in response to the intensity (luminance) of light that falls on the retina of the eye, thereby assisting in adaptation to various levels of darkness and light, in addition to retinal sensitivity.\" [wikipedia:Pupillary_light_reflex]" []
+synonym: "pupillary reflex" EXACT []
 is_a: NBO:0000411 ! cranial nerve related reflex
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000445
 name: tail movement
+namespace: behavior_ontology
 is_a: NBO:0000001 ! body part movement
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000451
 name: personal grooming
+namespace: behavior_ontology
+alt_id: NBO:0000058
+def: "\"Behavior related to the promotion of personal hygiene.\" [wikipedia:Social_grooming]" []
+synonym: "auto-grooming" EXACT []
+synonym: "autohygiene" EXACT []
+synonym: "preening" EXACT []
+synonym: "self-grooming" EXACT []
 is_a: NBO:0000027 ! grooming behavior
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000545
 name: swallowing
+namespace: behavior_ontology
+def: "The act of moving food from the mouth cavity to the esophagus through coordinated muscular movements [NBO:AC]" []
+synonym: "swallow" EXACT []
 is_a: NBO:0000079 ! feeding behavior
 relationship: part_of GO:0007631 ! feeding behavior
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000607
 name: cognitive behavior
+namespace: behavior_ontology
+def: "\"Behaviour related to cognitive processes.\" [NBO:JH]" []
 is_a: NBO:0000313 ! behavior process
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0000747
 name: jaw movement
+namespace: behavior_ontology
 is_a: NBO:0000007 ! mouth movement
+created_by: gkoutos
 
 [Term]
 id: NBO:0000751
 name: perception behavior by means
+namespace: behavior_ontology
 is_a: NBO:0000308 ! sensation behavior
+created_by: gkoutos
 
 [Term]
 id: NBO:0001786
 name: regulation of behavior
+def: "\"Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.\" [GO:0050795]" []
+xref: GO:0050795
 is_a: NBO:0000313 ! behavior process
 relationship: regulates NBO:0000313 ! behavior process
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0001845
 name: consumption behavior
+def: "\"Behavior related to the intake of substances.\" [NBOC:GVG]" []
+synonym: "ingest" BROAD []
 is_a: NBO:0000313 ! behavior process
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0002169
 name: regulation of consumption behavior
+def: "\"Any process that modulates the frequency, rate or extent of consumption behavior, the specific actions or reactions of an organism in response to external or internal stimuli.\" [NBOC:GVG]" []
 is_a: NBO:0001786 ! regulation of behavior
 relationship: regulates NBO:0001845 ! consumption behavior
+created_by: George Gkoutos
 
 [Term]
 id: NBO:0002436
 name: regulation of feeding behavior
+def: "\"Any process that modulates the frequency, rate or extent of consumption of food or liquid\" [NBOC:GVG]" []
 is_a: NBO:0002169 ! regulation of consumption behavior
+created_by: George Gkoutos
 
 [Term]
 id: NCBITaxon:1
@@ -41910,6 +42914,9 @@ union_of: NCBITaxon:2759 ! Eukaryota
 [Term]
 id: PATO:0000001
 name: quality
+namespace: quality
+alt_id: PATO:0000072
+def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG]
 is_a: BFO:0000020 ! specifically dependent continuant
 
 [Term]
@@ -41936,11 +42943,20 @@ is_a: PATO:0001546 ! quality of a solid
 [Term]
 id: PATO:0000051
 name: morphology
+namespace: quality
+def: "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." [PATOC:GVG]
+subset: attribute_slim
 is_a: PATO:0001241 ! physical object quality
 
 [Term]
 id: PATO:0000052
 name: shape
+namespace: quality
+alt_id: PATO:0001647
+def: "A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc)." [PATOC:GVG]
+comment: Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects.
+subset: attribute_slim
+synonym: "relational shape quality" EXACT []
 is_a: PATO:0000051 ! morphology
 
 [Term]
@@ -42113,6 +43129,12 @@ is_a: PATO:0000992 ! viscosity
 [Term]
 id: PATO:0001018
 name: physical quality
+namespace: quality
+alt_id: PATO:0002079
+def: "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." [PATOC:GVG]
+subset: attribute_slim
+synonym: "relational physical quality" EXACT []
+xref: Wikipedia:Physical_property
 is_a: PATO:0001241 ! physical object quality
 
 [Term]
@@ -42163,6 +43185,20 @@ is_a: PATO:0000001 ! quality
 [Term]
 id: PATO:0001241
 name: physical object quality
+namespace: quality
+alt_id: PATO:0001237
+alt_id: PATO:0001238
+def: "A quality which inheres in a continuant." [PATOC:GVG]
+comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles.
+synonym: "monadic quality of a continuant" EXACT []
+synonym: "monadic quality of an object" NARROW []
+synonym: "monadic quality of continuant" NARROW []
+synonym: "multiply inhering quality of a physical entity" EXACT []
+synonym: "quality of a continuant" EXACT []
+synonym: "quality of a single physical entity" EXACT []
+synonym: "quality of an object" EXACT []
+synonym: "quality of continuant" EXACT []
+xref: snap:Quality
 is_a: BFO:0000019 ! quality
 is_a: PATO:0000001 ! quality
 
@@ -42281,6 +43317,10 @@ is_a: PATO:0002198 ! quality of a substance
 [Term]
 id: PATO:0001548
 name: quality of a liquid
+namespace: quality
+def: "A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape." [url:http\://www.chemistry-dictionary.com/definition/liquid.php]
+subset: attribute_slim
+synonym: "liquidity" EXACT []
 is_a: PATO:0002198 ! quality of a substance
 
 [Term]
@@ -42511,7 +43551,12 @@ is_a: PATO:0001241 ! physical object quality
 [Term]
 id: PATO:0002198
 name: quality of a substance
+namespace: quality
+def: "A quality inhering in a bearer by virtue of its constitution." [PATOC:GVG]
+subset: attribute_slim
 is_a: PATO:0001018 ! physical quality
+created_by: George Gkoutos
+creation_date: 2010-03-15T04:35:27Z
 
 [Term]
 id: PATO:0002236
@@ -43516,11 +44561,6 @@ is_a: UBERON:0003296 ! gland of diencephalon
 is_a: UBERON:0010133 ! neuroendocrine gland
 relationship: capable_of_part_of GO:0007276 ! gamete generation
 relationship: contributes_to_morphology_of UBERON:0001894 ! diencephalon
-relationship: develops_from UBERON:0000033 ! head
-relationship: develops_from UBERON:0000153 ! anterior region of body
-relationship: develops_from UBERON:0007811 ! craniocervical region
-relationship: develops_from UBERON:0013701 ! main body axis
-relationship: develops_from UBERON:0013702 ! body proper
 relationship: develops_from UBERON:0034875 ! future pituitary gland
 relationship: has_part CL:0000440 {source="ZFA"} ! melanocyte stimulating hormone secreting cell
 relationship: has_part CL:0000642 {source="ZFA"} ! folliculostellate cell
@@ -44483,7 +45523,7 @@ xref: VHOG:0000222
 xref: XAO:0000210
 xref: ZFA:0000200
 is_a: UBERON:0001800 {source="MA"} ! sensory ganglion
-is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010313 ! neural crest-derived structure
 intersection_of: UBERON:0000045 ! ganglion
 intersection_of: extends_fibers_into UBERON:0001780 ! spinal nerve
 intersection_of: extends_fibers_into UBERON:0002261 ! dorsal root of spinal cord
@@ -44698,6 +45738,7 @@ xref: TAO:0000386
 xref: ZFA:0000386
 is_a: UBERON:0000479 ! tissue
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: has_part GO:0070451 ! cell hair
 relationship: part_of UBERON:0001846 ! internal ear
 
@@ -48826,6 +49867,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/280626006
 xref: MESH:A09.371.509.225
 is_a: UBERON:0000479 ! tissue
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0000479 ! tissue
 intersection_of: surrounds UBERON:0000390 ! lens nucleus
 relationship: develops_from UBERON:0005614 ! lens anterior epithelium
@@ -48842,6 +49884,7 @@ xref: FMA:58971
 xref: http://www.snomedbrowser.com/Codes/Details/280628007
 xref: MESH:A09.371.509.670
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0034944 ! zone of organ
 intersection_of: UBERON:0034944 ! zone of organ
 intersection_of: surrounded_by UBERON:0000389 ! lens cortex
@@ -49448,7 +50491,7 @@ xref: EMAPA:35446
 xref: FMA:77597
 xref: MA:0001147
 is_a: UBERON:0001816 ! autonomic nerve plexus
-is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010313 ! neural crest-derived structure
 intersection_of: UBERON:0001810 ! nerve plexus
 intersection_of: part_of UBERON:0002005 ! enteric nervous system
 relationship: part_of UBERON:0002005 ! enteric nervous system
@@ -49689,8 +50732,8 @@ name: habenular trigone
 def: "The habenular trigone is a small depressed triangular area situated in front of the superior colliculus and on the lateral aspect of the posterior part of the taenia thalami. It contains a group of nerve cells termed the ganglion habenulC&. Fibers enter it from the stalk of the pineal body, and others, forming what is termed the habenular commissure, pass across the middle line to the corresponding ganglion of the opposite side. Most of its fibers are, however, directed downward and form a bundle, the fasciculus retroflexus of Meynert, which passes medial to the red nucleus, and, after decussating with the corresponding fasciculus of the opposite side, ends in the interpeduncular ganglion." [http://en.wikipedia.org/wiki/Habenular_trigone]
 comment: superclass in BTO is thalamic nucleus, not present in most ontologies
 synonym: "trigone of habenulae" RELATED [BTO:0002700]
-synonym: "trigonum habenulae" RELATED LATIN [http://en.wikipedia.org/wiki/Habenular_trigone]
 synonym: "trigonum habenulae" RELATED [BTO:0002700]
+synonym: "trigonum habenulae" RELATED LATIN [http://en.wikipedia.org/wiki/Habenular_trigone]
 xref: BAMS:hbt
 xref: BTO:0002700
 xref: FMA:74868
@@ -51219,7 +52262,6 @@ xref: VHOG:0000153
 xref: XAO:0000001
 xref: ZFA:0000016
 is_a: UBERON:0000923 ! germ layer
-relationship: develops_from UBERON:0000307 ! blastula
 relationship: develops_from UBERON:0006601 ! presumptive ectoderm
 relationship: has_part CL:0000221 ! ectodermal cell
 relationship: immediate_transformation_of UBERON:0006601 {source="Bgee:AN"} ! presumptive ectoderm
@@ -51257,7 +52299,6 @@ xref: VHOG:0000154
 xref: XAO:0000090
 xref: ZFA:0000017
 is_a: UBERON:0000923 ! germ layer
-relationship: develops_from UBERON:0000307 ! blastula
 relationship: develops_from UBERON:0006595 ! presumptive endoderm
 relationship: has_part CL:0000223 ! endodermal cell
 relationship: immediate_transformation_of UBERON:0006595 {source="Bgee:AN"} ! presumptive endoderm
@@ -51301,7 +52342,6 @@ xref: VHOG:0000152
 xref: XAO:0000050
 xref: ZFA:0000041
 is_a: UBERON:0000923 {notes="sometimes not considered primary"} ! germ layer
-relationship: develops_from UBERON:0000307 ! blastula
 relationship: develops_from UBERON:0006603 ! presumptive mesoderm
 relationship: has_part CL:0000222 ! mesodermal cell
 relationship: immediate_transformation_of UBERON:0006603 {source="Bgee:AN"} ! presumptive mesoderm
@@ -52068,7 +53108,6 @@ relationship: composed_primarily_of CL:0002319 ! neural cell
 relationship: contributes_to_morphology_of UBERON:0001016 ! nervous system
 property_value: dc-contributor https://github.com/cmungall
 relationship: develops_from UBERON:0001049 {gci_relation="part_of", gci_filler="NCBITaxon:7711"} ! neural tube
-relationship: develops_from UBERON:0002346 ! neurectoderm
 relationship: develops_from UBERON:0006238 ! future brain
 relationship: existence_ends_during UBERON:0000066 ! fully formed stage
 relationship: immediate_transformation_of UBERON:0006238 {source="Bgee:AN"} ! future brain
@@ -53340,7 +54379,6 @@ xref: UMLS:C0042149 {source="ncithesaurus:Uterus"}
 xref: VHOG:0001137
 is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0013515 {source="cjm"} ! subdivision of oviduct
-relationship: develops_from UBERON:0000922 ! embryo
 relationship: develops_from UBERON:0005795 ! embryonic uterus
 relationship: immediate_transformation_of UBERON:0005795 ! embryonic uterus
 relationship: only_in_taxon NCBITaxon:32525 ! Theria <mammals>
@@ -54071,7 +55109,6 @@ disjoint_from: UBERON:0002423 ! hepatobiliary system
 disjoint_from: UBERON:0004456 ! entire sense organ system
 relationship: capable_of GO:0050877 ! nervous system process
 relationship: composed_primarily_of CL:0002319 ! neural cell
-relationship: develops_from UBERON:0000922 ! embryo
 relationship: develops_from UBERON:0016880 ! future nervous system
 relationship: existence_ends_during UBERON:0000066 ! fully formed stage
 relationship: has_part CL:0000540 ! neuron
@@ -55924,6 +56961,7 @@ xref: VHOG:0001733
 xref: XAO:0000431
 xref: ZFA:0000694
 is_a: UBERON:0003913 ! tooth-like structure
+is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: develops_from UBERON:0008281 ! tooth bud
 relationship: has_developmental_contribution_from UBERON:0000930 {source="XAO-modified"} ! stomodeum
@@ -58302,10 +59340,6 @@ relationship: channel_for UBERON:0001970 ! bile
 relationship: channels_into UBERON:0001174 ! common bile duct
 relationship: continuous_with UBERON:0001176 {source="Wikipedia"} ! right hepatic duct
 relationship: continuous_with UBERON:0001177 {source="Wikipedia"} ! left hepatic duct
-relationship: develops_from UBERON:0001007 ! digestive system
-relationship: develops_from UBERON:0001173 ! biliary tree
-relationship: develops_from UBERON:0002294 ! biliary system
-relationship: develops_from UBERON:0002423 ! hepatobiliary system
 relationship: develops_from UBERON:0010081 ! future common hepatic duct
 relationship: immediate_transformation_of UBERON:0010081 {evidence="definitional"} ! future common hepatic duct
 relationship: part_of UBERON:0005604 {source="MA"} ! extrahepatic part of hepatic duct
@@ -61376,17 +62410,8 @@ xref: ZFA:0005282
 is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0000064 ! organ part
 relationship: contributes_to_morphology_of UBERON:0002113 ! kidney
-relationship: develops_from UBERON:0000468 ! multicellular organism
-relationship: develops_from UBERON:0000916 ! abdomen
-relationship: develops_from UBERON:0001008 ! renal system
-relationship: develops_from UBERON:0002100 ! trunk
-relationship: develops_from UBERON:0002113 ! kidney
-relationship: develops_from UBERON:0002417 ! abdominal segment of trunk
 relationship: develops_from UBERON:0004208 {evidence="definitional"} ! nephrogenic mesenchyme
 relationship: develops_from UBERON:0010532 ! primitive nephron
-relationship: develops_from UBERON:0011143 ! upper urinary tract
-relationship: develops_from UBERON:0013701 ! main body axis
-relationship: develops_from UBERON:0013702 ! body proper
 relationship: immediate_transformation_of UBERON:0010532 {source="Bgee:AN"} ! primitive nephron
 relationship: part_of UBERON:0007684 {source="FMA"} ! uriniferous tubule
 
@@ -61801,10 +62826,6 @@ is_a: UBERON:0035651 ! glans
 intersection_of: UBERON:0035651 ! glans
 intersection_of: part_of UBERON:0000989 ! penis
 relationship: contributes_to_morphology_of UBERON:0000989 ! penis
-relationship: develops_from UBERON:0000079 ! male reproductive system
-relationship: develops_from UBERON:0003101 ! male organism
-relationship: develops_from UBERON:0004053 ! external male genitalia
-relationship: develops_from UBERON:0006261 ! male genital tubercle
 relationship: develops_from UBERON:0013239 ! future glans penis
 relationship: immediate_transformation_of UBERON:0013239 {source="Bgee:AN"} ! future glans penis
 relationship: part_of UBERON:0000989 ! penis
@@ -63058,6 +64079,7 @@ xref: MA:0001298
 xref: NCIT:C32909
 xref: UMLS:C0229289 {source="ncithesaurus:Lacrimal_Sac"}
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0034944 ! zone of organ
 relationship: part_of UBERON:0002392 ! nasolacrimal duct
 
@@ -63092,6 +64114,7 @@ xref: UMLS:C0013444 {source="ncithesaurus:External_Acoustic_Meatus"}
 xref: VHOG:0000977
 is_a: UBERON:0004111 ! anatomical conduit
 is_a: UBERON:0004119 ! endoderm-derived structure
+is_a: UBERON:0004121 ! ectoderm-derived structure
 relationship: capable_of_part_of GO:0055127 ! vibrational conductance of sound to the inner ear
 relationship: develops_from UBERON:0005872 {source="http://www.ncbi.nlm.nih.gov/pubmed/11237469"} ! 1st arch pharyngeal cleft
 relationship: part_of UBERON:0001691 {source="FMA"} ! external ear
@@ -65936,6 +66959,7 @@ xref: MA:0001233
 xref: NCIT:C49481
 xref: UMLS:C0222110 {source="ncithesaurus:Ear_Skin"}
 is_a: UBERON:0001084 ! skin of head
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0000014 ! zone of skin
 intersection_of: part_of UBERON:0001691 ! external ear
 relationship: part_of UBERON:0001691 ! external ear
@@ -68379,7 +69403,6 @@ xref: ZFA:0000112
 is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0000025 ! tube
 relationship: connects UBERON:0000165 ! mouth
-relationship: develops_from UBERON:0000922 ! embryo
 relationship: develops_from UBERON:0007026 ! presumptive gut
 relationship: immediate_transformation_of UBERON:0007026 {source="NCBIBook:NBK10107"} ! presumptive gut
 relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
@@ -69359,6 +70382,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/244757006
 xref: MA:0001229
 is_a: CARO:0000003
 is_a: UBERON:0001630 ! muscle organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: attaches_to UBERON:0001848 ! auricular cartilage
 relationship: part_of RO:0002577 ! system
 relationship: part_of UBERON:0001757 {source="MA"} ! pinna
@@ -69954,26 +70978,7 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre
 intersection_of: UBERON:0001637 ! artery
 intersection_of: directly_develops_from UBERON:0003118 ! pharyngeal arch artery 1
 relationship: connected_to UBERON:0001070 {subset="human_reference_atlas"} ! external carotid artery
-relationship: develops_from NCBITaxon:6072 ! Eumetazoa
-relationship: develops_from UBERON:0000062 ! organ
-relationship: develops_from UBERON:0000153 ! anterior region of body
-relationship: develops_from UBERON:0001004 ! respiratory system
-relationship: develops_from UBERON:0001007 ! digestive system
-relationship: develops_from UBERON:0001009 ! circulatory system
-relationship: develops_from UBERON:0001041 ! foregut
-relationship: develops_from UBERON:0001042 ! chordate pharynx
-relationship: develops_from UBERON:0001555 ! digestive tract
 relationship: develops_from UBERON:0003118 ! pharyngeal arch artery 1
-relationship: develops_from UBERON:0004362 ! pharyngeal arch 1
-relationship: develops_from UBERON:0004535 ! cardiovascular system
-relationship: develops_from UBERON:0004572 ! arterial system
-relationship: develops_from UBERON:0007303 ! pharyngeal vasculature
-relationship: develops_from UBERON:0007811 ! craniocervical region
-relationship: develops_from UBERON:0008814 ! pharyngeal arch system
-relationship: develops_from UBERON:0008816 ! embryonic head
-relationship: develops_from UBERON:0011362 ! cranial blood vasculature
-relationship: develops_from UBERON:0013701 ! main body axis
-relationship: develops_from UBERON:0013702 ! body proper
 relationship: directly_develops_from UBERON:0003118 ! pharyngeal arch artery 1
 relationship: part_of RO:0002577 ! system
 
@@ -70696,6 +71701,7 @@ xref: MA:0001867
 xref: NCIT:C12515
 xref: OpenCyc:Mx4rv9naEJwpEbGdrcN5Y29ycA
 xref: UMLS:C0226859 {source="ncithesaurus:Superior_Sagittal_Sinus"}
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0015704 ! sagittal sinus
 relationship: develops_from UBERON:0009968 {source="cjm"} ! primitive superior sagittal sinus
 
@@ -71292,6 +72298,7 @@ xref: NCIT:C53128
 xref: UMLS:C0226541 {source="ncithesaurus:Submental_Vein"}
 is_a: UBERON:0003496 ! head blood vessel
 is_a: UBERON:0009141 ! craniocervical region vein
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001653 ! facial vein
 relationship: part_of UBERON:0008199 ! chin
 relationship: tributary_of UBERON:0001653 {source="FMA/obol"} ! facial vein
@@ -72150,7 +73157,6 @@ xref: VHOG:0000688
 is_a: UBERON:0001686 ! auditory ossicle bone
 is_a: UBERON:0002513 ! endochondral bone
 is_a: UBERON:0004119 ! endoderm-derived structure
-is_a: UBERON:0010313 ! neural crest-derived structure
 is_a: UBERON:0015016 ! stapes endochondral element
 intersection_of: UBERON:0015016 ! stapes endochondral element
 intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue
@@ -72211,7 +73217,6 @@ xref: UMLS:C0024631 {source="ncithesaurus:Malleus"}
 xref: VHOG:0000690
 is_a: UBERON:0001686 ! auditory ossicle bone
 is_a: UBERON:0002513 ! endochondral bone
-is_a: UBERON:0010313 ! neural crest-derived structure
 is_a: UBERON:0015018 ! malleus endochondral element
 intersection_of: UBERON:0015018 ! malleus endochondral element
 intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue
@@ -72334,6 +73339,7 @@ xref: TAO:0000472
 xref: VHOG:0001152
 xref: ZFA:0000472
 is_a: UBERON:0002513 ! endochondral bone
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011164 ! neurocranium bone
 is_a: UBERON:0015048 ! basioccipital endochondral element
 intersection_of: UBERON:0015048 ! basioccipital endochondral element
@@ -72368,6 +73374,7 @@ xref: TAO:0000661
 xref: VHOG:0001151
 xref: ZFA:0000661
 is_a: UBERON:0002513 {source="ZFA"} ! endochondral bone
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011164 ! neurocranium bone
 is_a: UBERON:0015051 ! exoccipital endochondral element
 intersection_of: UBERON:0015051 ! exoccipital endochondral element
@@ -73360,16 +74367,8 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre
 is_a: UBERON:0013765 ! digestive system element
 relationship: adjacent_to UBERON:0000166 ! oral opening
 relationship: contributes_to_morphology_of UBERON:0001007 ! digestive system
-relationship: develops_from UBERON:0000033 ! head
-relationship: develops_from UBERON:0000153 ! anterior region of body
-relationship: develops_from UBERON:0000165 ! mouth
-relationship: develops_from UBERON:0001007 ! digestive system
-relationship: develops_from UBERON:0001555 ! digestive tract
-relationship: develops_from UBERON:0007811 ! craniocervical region
 relationship: develops_from UBERON:0008814 ! pharyngeal arch system
 relationship: develops_from UBERON:0010056 ! future tongue
-relationship: develops_from UBERON:0013701 ! main body axis
-relationship: develops_from UBERON:0013702 ! body proper
 relationship: has_developmental_contribution_from UBERON:0006260 {notes="anterior 2/3"} ! lingual swellings
 relationship: has_developmental_contribution_from UBERON:0006756 {source="Wikipedia"} ! median lingual swelling
 relationship: has_developmental_contribution_from UBERON:0006757 {source="Wikipedia"} ! lateral lingual swelling
@@ -74281,6 +75280,7 @@ xref: Pinna:(anatomy)
 xref: UMLS:C0928075 {source="ncithesaurus:Auricle"}
 xref: VHOG:0000460
 is_a: UBERON:0001444 ! subdivision of head
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: continuous_with UBERON:0001352 ! external acoustic meatus
 relationship: develops_from UBERON:0006208 ! auditory hillocks
 relationship: has_quality PATO:0001297 ! reflectivity
@@ -74435,6 +75435,7 @@ xref: OpenCyc:Mx4rv07bVJwpEbGdrcN5Y29ycA
 xref: UMLS:C1266928 {source="ncithesaurus:Nasal_Turbinate"}
 is_a: UBERON:0002513 ! endochondral bone
 is_a: UBERON:0005913 ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011164 ! neurocranium bone
 is_a: UBERON:0035612 ! nasal turbinal
 intersection_of: UBERON:0035612 ! nasal turbinal
@@ -75105,7 +76106,6 @@ intersection_of: UBERON:0001781 ! layer of retina
 intersection_of: immediate_transformation_of UBERON:0005424 ! presumptive retinal pigmented epithelium
 relationship: adjacent_to UBERON:0001787 {source="Wikipedia"} ! photoreceptor layer of retina
 relationship: adjacent_to UBERON:0003902 ! retinal neural layer
-relationship: develops_from NCBITaxon:6072 ! Eumetazoa
 relationship: develops_from UBERON:0005424 ! presumptive retinal pigmented epithelium
 relationship: has_part GO:0048770 ! pigment granule
 relationship: immediate_transformation_of UBERON:0005424 ! presumptive retinal pigmented epithelium
@@ -75805,6 +76805,7 @@ xref: VHOG:0000550
 xref: ZFA:0005574
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005764 ! acellular membrane
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0000476 ! acellular anatomical structure
 intersection_of: bounding_layer_of UBERON:0000965 ! lens of camera-type eye
 relationship: bounding_layer_of UBERON:0000965 ! lens of camera-type eye
@@ -75869,7 +76870,7 @@ xref: NCIT:C12467
 xref: Sympathetic:ganglion
 xref: UMLS:C0017071 {source="ncithesaurus:Sympathetic_Ganglion"}
 is_a: UBERON:0001805 ! autonomic ganglion
-is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010313 ! neural crest-derived structure
 intersection_of: UBERON:0000045 ! ganglion
 intersection_of: part_of UBERON:0000013 ! sympathetic nervous system
 relationship: contributes_to_morphology_of UBERON:0000013 ! sympathetic nervous system
@@ -76064,8 +77065,8 @@ name: brachial nerve plexus
 def: "An arrangement of nerve fibers, running from the spine where it proceeds through the neck then the axilla and into the arm where it innervates skin and muscle. [WP,modified]." [http://en.wikipedia.org/wiki/Brachial_plexus, UBERON:cjm]
 subset: uberon_slim
 synonym: "brachial plexus" EXACT [MA:0001180]
-synonym: "plexus brachialis" RELATED LATIN [http://en.wikipedia.org/wiki/Brachial_plexus]
 synonym: "plexus brachialis" RELATED [http://en.wikipedia.org/wiki/Brachial_plexus]
+synonym: "plexus brachialis" RELATED LATIN [http://en.wikipedia.org/wiki/Brachial_plexus]
 xref: Brachial:plexus
 xref: EHDAA2:0000180
 xref: EHDAA:3782
@@ -76160,6 +77161,7 @@ xref: VHOG:0001476
 is_a: UBERON:0002365 ! exocrine gland
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0004859 ! eye gland
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0015154 ! lateral gland of orbital region
 intersection_of: UBERON:0002530 ! gland
 intersection_of: part_of UBERON:0001750 ! lacrimal apparatus
@@ -76546,6 +77548,7 @@ xref: UMLS:C0030580 {source="ncithesaurus:Parotid_Gland"}
 xref: VHOG:0000308
 is_a: UBERON:0000409 ! serous gland
 is_a: UBERON:0001829 ! major salivary gland
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0012102 ! buccal salivary gland
 disjoint_from: UBERON:0013219 ! parotoid gland
 relationship: develops_from UBERON:0008801 ! parotid gland primordium
@@ -76640,20 +77643,7 @@ is_a: UBERON:0001833 ! lip
 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0001833 ! lip
 intersection_of: part_of UBERON:0001709 ! upper jaw region
-relationship: develops_from UBERON:0000033 ! head
-relationship: develops_from UBERON:0000062 ! organ
-relationship: develops_from UBERON:0000153 ! anterior region of body
-relationship: develops_from UBERON:0000165 ! mouth
-relationship: develops_from UBERON:0001007 ! digestive system
-relationship: develops_from UBERON:0001456 ! face
-relationship: develops_from UBERON:0001555 ! digestive tract
-relationship: develops_from UBERON:0001709 ! upper jaw region
-relationship: develops_from UBERON:0004089 ! midface
-relationship: develops_from UBERON:0007811 ! craniocervical region
 relationship: develops_from UBERON:0011592 ! future upper lip
-relationship: develops_from UBERON:0011595 ! jaw region
-relationship: develops_from UBERON:0013701 ! main body axis
-relationship: develops_from UBERON:0013702 ! body proper
 relationship: immediate_transformation_of UBERON:0011592 ! future upper lip
 relationship: part_of UBERON:0001709 ! upper jaw region
 
@@ -76786,6 +77776,7 @@ xref: UMLS:C0458699 {source="ncithesaurus:Osseous_Labyrinth"}
 xref: VHOG:0001219
 xref: XAO:0000193
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0034921 ! multi organ part structure
 relationship: part_of UBERON:0001694 {source="FMA", source="MA"} ! petrous part of temporal bone
 relationship: part_of UBERON:0001846 {source="FMA"} ! internal ear
@@ -76823,6 +77814,7 @@ xref: XAO:0000198
 xref: ZFA:0000431
 is_a: UBERON:0000025 {source="GO"} ! tube
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: develops_from UBERON:0003051 ! ear vesicle
 relationship: part_of UBERON:0001846 {source="MA"} ! internal ear
 relationship: part_of UBERON:0001849 {source="OG"} ! membranous labyrinth
@@ -76943,6 +77935,7 @@ xref: VHOG:0000691
 xref: XAO:0000197
 xref: ZFA:0000374
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0034921 ! multi organ part structure
 relationship: contributes_to_morphology_of UBERON:0001846 ! internal ear
 relationship: has_quality PATO:0000404 {gci_relation="part_of", gci_filler="NCBITaxon:32525", source="Wikipedia"} ! coiled
@@ -77017,6 +78010,7 @@ xref: VHOG:0000284
 xref: XAO:0000192
 xref: ZFA:0000217
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0034921 ! multi organ part structure
 relationship: develops_from UBERON:0003051 {evidence="definitional"} ! ear vesicle
 relationship: part_of UBERON:0001690 ! ear
@@ -77043,6 +78037,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/362544006
 xref: MA:0002468
 xref: NCIT:C32999
 xref: UMLS:C0229315 {source="ncithesaurus:Lobule_of_the_Auricle"}
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0034929 ! external soft tissue zone
 relationship: contributes_to_morphology_of UBERON:0001691 ! external ear
 relationship: has_part UBERON:0001013 ! adipose tissue
@@ -77060,7 +78055,7 @@ xref: EMAPA:35158
 xref: FMA:61013
 xref: http://www.snomedbrowser.com/Codes/Details/279627003
 xref: MA:0001227
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0034944 ! zone of organ
 intersection_of: UBERON:0034944 ! zone of organ
 intersection_of: part_of UBERON:0001757 ! pinna
@@ -77093,6 +78088,7 @@ xref: VHOG:0000729
 xref: XAO:0000194
 is_a: UBERON:0000062 ! organ
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: develops_from UBERON:0003051 ! ear vesicle
 relationship: located_in UBERON:0004637 ! otic capsule
 relationship: part_of UBERON:0001846 {source="FMA", source="MA"} ! internal ear
@@ -77267,6 +78263,7 @@ xref: UMLS:C1323110 {source="BIRNLEX:2562"}
 xref: VHOG:0000507
 is_a: UBERON:0000025 ! tube
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0002499 {source="FMA", source="MA"} ! cochlear labyrinth
 
 [Term]
@@ -77285,6 +78282,7 @@ xref: UMLS:C1323109 {source="ncithesaurus:Semicircular_Duct"}
 xref: VHOG:0000238
 is_a: UBERON:0000025 ! tube
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001840 {source="MA"} ! semicircular canal
 relationship: part_of UBERON:0001862 {source="FMA", source="MA"} ! vestibular labyrinth
 
@@ -77356,6 +78354,7 @@ xref: TAO:0002194
 xref: ZFA:0001705
 is_a: UBERON:0000025 ! tube
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001849 ! membranous labyrinth
 
 [Term]
@@ -77374,6 +78373,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/279805009
 xref: MA:0000244
 is_a: UBERON:0000025 ! tube
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: connects UBERON:0001854 {source="Wikipedia"} ! saccule of membranous labyrinth
 relationship: connects UBERON:0001855 {source="Wikipedia"} ! cochlear duct of membranous labyrinth
 relationship: part_of UBERON:0001862 {source="EMAPA"} ! vestibular labyrinth
@@ -77403,6 +78403,7 @@ xref: UMLS:C0042606 {source="ncithesaurus:Vestibular_Labyrinth"}
 xref: XAO:0004145
 is_a: UBERON:0000064 ! organ part
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001849 ! membranous labyrinth
 
 [Term]
@@ -77453,6 +78454,7 @@ xref: FMA:61289
 xref: MA:0001234
 is_a: UBERON:0000025 ! tube
 is_a: UBERON:0004119 ! endoderm-derived structure
+is_a: UBERON:0004121 ! ectoderm-derived structure
 relationship: composed_primarily_of UBERON:0002418 ! cartilage tissue
 relationship: part_of UBERON:0001352 ! external acoustic meatus
 
@@ -78596,11 +79598,6 @@ xref: VHOG:0000741
 is_a: UBERON:0004733 ! segmental subdivision of hindbrain
 relationship: contributes_to_morphology_of UBERON:0002028 ! hindbrain
 property_value: dc-contributor https://github.com/cmungall
-relationship: develops_from NCBITaxon:6072 ! Eumetazoa
-relationship: develops_from UBERON:0000955 ! brain
-relationship: develops_from UBERON:0001016 ! nervous system
-relationship: develops_from UBERON:0001017 ! central nervous system
-relationship: develops_from UBERON:0002028 ! hindbrain
 relationship: develops_from UBERON:0010092 ! future metencephalon
 relationship: dubious_for_taxon NCBITaxon:7955 ! Danio rerio
 relationship: immediate_transformation_of UBERON:0010092 {evidence="definitional"} ! future metencephalon
@@ -82038,12 +83035,6 @@ intersection_of: part_of UBERON:0005386 ! olfactory segment of nasal mucosa
 relationship: capable_of_part_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell
 relationship: contributes_to_morphology_of UBERON:0000004 ! nose
 relationship: contributes_to_morphology_of UBERON:0005725 ! olfactory system
-relationship: develops_from UBERON:0000033 ! head
-relationship: develops_from UBERON:0000076 ! external ectoderm
-relationship: develops_from UBERON:0000153 ! anterior region of body
-relationship: develops_from UBERON:0007811 ! craniocervical region
-relationship: develops_from UBERON:0013701 ! main body axis
-relationship: develops_from UBERON:0013702 ! body proper
 relationship: develops_from UBERON:2001431 ! primitive olfactory epithelium
 relationship: has_part CL:0000207 {source="NBK26868"} ! olfactory receptor cell
 relationship: has_part CL:0000853 {source="NBK26868"} ! olfactory epithelial supporting cell
@@ -82228,7 +83219,7 @@ xref: MIAA:0000102
 xref: TAO:0001155
 xref: UMLS:C0206111 {source="BIRNLEX:1166"}
 xref: ZFA:0001155
-is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010313 ! neural crest-derived structure
 is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision
 relationship: contributes_to_morphology_of UBERON:0002410 ! autonomic nervous system
 relationship: develops_from UBERON:0005428 {source="https://github.com/obophenotype/uberon/wiki/The-neural-crest", source="Wikipedia", source="ZFA"} ! vagal neural crest
@@ -84189,8 +85180,6 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre
 is_a: UBERON:0013754 ! integumentary system layer
 relationship: composed_primarily_of UBERON:0002384 ! connective tissue
 relationship: deep_to UBERON:0001003 ! skin epidermis
-relationship: develops_from UBERON:0002199 ! integument
-relationship: develops_from UBERON:0002416 ! integumental system
 relationship: develops_from UBERON:0010083 ! future dermis
 relationship: has_developmental_contribution_from UBERON:0002342 {source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neural crest
 relationship: has_part GO:0071953 ! elastic fiber
@@ -88900,6 +89889,7 @@ xref: UMLS:C0004816 {source="BIRNLEX:2521"}
 xref: UMLS:C0004816 {source="ncithesaurus:Basilar_Membrane"}
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005764 {source="Wikipedia"} ! acellular membrane
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: adjacent_to UBERON:0001864 ! scala tympani
 relationship: adjacent_to UBERON:0002295 ! scala media
 relationship: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth
@@ -88940,6 +89930,7 @@ xref: UMLS:C0029207 {source="BIRNLEX:2526"}
 xref: VHOG:0001567
 is_a: UBERON:0000020 ! sense organ
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound
 relationship: dubious_for_taxon NCBITaxon:8292 ! Amphibia
 relationship: dubious_for_taxon NCBITaxon:8457 ! Sauropsida
@@ -89098,6 +90089,7 @@ xref: UMLS:C1184928 {source="BIRNLEX:2531"}
 is_a: CARO:0000003
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005764 {source="Wikipedia"} ! acellular membrane
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: attaches_to UBERON:0002276 {notes="limbal zone"} ! lamina of spiral limbus
 relationship: part_of RO:0002577 ! system
 relationship: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth
@@ -89288,8 +90280,6 @@ is_a: UBERON:0000489 ! cavitated compound organ
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005174 ! dorsal region element
 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
-relationship: develops_from UBERON:0001016 ! nervous system
-relationship: develops_from UBERON:0001017 ! central nervous system
 relationship: develops_from UBERON:0003076 ! posterior neural tube
 relationship: develops_from UBERON:0006241 ! future spinal cord
 relationship: has_developmental_contribution_from UBERON:0003853 {evidence="definitional"} ! spinal cord neural crest
@@ -89387,30 +90377,7 @@ xref: ZFA:0000567
 is_a: UBERON:0002514 ! intramembranous bone
 is_a: UBERON:0008907 ! dermal bone
 is_a: UBERON:0011597 ! bone of upper jaw
-relationship: develops_from UBERON:0000033 ! head
-relationship: develops_from UBERON:0000153 ! anterior region of body
-relationship: develops_from UBERON:0000165 ! mouth
-relationship: develops_from UBERON:0001007 ! digestive system
-relationship: develops_from UBERON:0001434 ! skeletal system
-relationship: develops_from UBERON:0001456 ! face
-relationship: develops_from UBERON:0001555 ! digestive tract
-relationship: develops_from UBERON:0001708 ! jaw skeleton
-relationship: develops_from UBERON:0001709 ! upper jaw region
-relationship: develops_from UBERON:0002204 ! musculoskeletal system
-relationship: develops_from UBERON:0003113 ! dermatocranium
-relationship: develops_from UBERON:0003129 ! skull
-relationship: develops_from UBERON:0003277 ! skeleton of upper jaw
-relationship: develops_from UBERON:0004089 ! midface
-relationship: develops_from UBERON:0004288 ! skeleton
-relationship: develops_from UBERON:0007811 ! craniocervical region
-relationship: develops_from UBERON:0010323 ! cranial skeletal system
-relationship: develops_from UBERON:0010364 ! dermal skeleton
-relationship: develops_from UBERON:0011137 ! axial skeletal system
-relationship: develops_from UBERON:0011156 ! facial skeleton
-relationship: develops_from UBERON:0011595 ! jaw region
 relationship: develops_from UBERON:0011628 ! early premaxilla
-relationship: develops_from UBERON:0013701 ! main body axis
-relationship: develops_from UBERON:0013702 ! body proper
 relationship: immediate_transformation_of UBERON:0011628 {source="Bgee:AN"} ! early premaxilla
 relationship: part_of UBERON:0003113 {source="ISBN:0073040584"} ! dermatocranium
 relationship: part_of UBERON:0003277 {source="VHOG"} ! skeleton of upper jaw
@@ -90262,6 +91229,7 @@ xref: http://en.wikipedia.org/wiki/Limbus_laminae_spiralis
 xref: MA:0001191
 is_a: UBERON:0000064 ! organ part
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001855 {source="MA"} ! cochlear duct of membranous labyrinth
 
 [Term]
@@ -90308,6 +91276,7 @@ xref: MA:0001186
 xref: MESH:D014723
 xref: Vestibular:aqueduct
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0013685 ! foramen of skull
 intersection_of: UBERON:0013685 ! foramen of skull
 intersection_of: conduit_for UBERON:0036074 ! vein of vestibular aqueduct
@@ -90343,6 +91312,7 @@ xref: UMLS:C0029894 {source="ncithesaurus:Otolith"}
 xref: ZFA:0001617
 is_a: UBERON:0000476 ! acellular anatomical structure
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: capable_of_part_of GO:0009590 ! detection of gravity
 relationship: composed_primarily_of CHEBI:3311 ! calcium carbonate
 relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
@@ -90371,6 +91341,7 @@ xref: NCIT:C33083
 xref: Reissner's:membrane
 is_a: UBERON:0000094 ! membrane organ
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: adjacent_to UBERON:0001863 ! scala vestibuli
 relationship: adjacent_to UBERON:0002295 ! scala media
 relationship: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth
@@ -90667,6 +91638,7 @@ xref: UMLS:C0007769 {source="ncithesaurus:Aqueduct_of_Sylvius"}
 xref: VHOG:0000832
 xref: ZFA:0000159
 is_a: UBERON:0004086 ! brain ventricle
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: develops_from UBERON:0013148 {source="EHDAA2"} ! early midbrain vesicle
 relationship: part_of UBERON:0001891 ! midbrain
 
@@ -92616,10 +93588,7 @@ is_a: UBERON:0000094 {source="FMA"} ! membrane organ
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: composed_primarily_of UBERON:0002384 ! connective tissue
-relationship: develops_from UBERON:0001016 ! nervous system
-relationship: develops_from UBERON:0001017 ! central nervous system
 relationship: develops_from UBERON:0007645 ! future meninx
-relationship: develops_from UBERON:0010743 ! meningeal cluster
 relationship: fma_set_term FMA:76821
 relationship: immediate_transformation_of UBERON:0007645 {source="Bgee:AN"} ! future meninx
 relationship: part_of UBERON:0010743 ! meningeal cluster
@@ -92755,8 +93724,8 @@ xref: Tympanic:membrane
 xref: UMLS:C0041445 {source="ncithesaurus:Tympanic_Membrane"}
 xref: VHOG:0001146
 xref: XAO:0000212
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0000094 {source="FMA"} ! membrane organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: adjacent_to UBERON:0004114 {source="cjm"} ! tympanic cavity
 relationship: contributes_to_morphology_of UBERON:0001756 ! middle ear
 relationship: develops_from UBERON:0009213 {source="Wikipedia"} ! pharyngeal membrane of 1st arch
@@ -93735,6 +94704,7 @@ xref: VHOG:0000664
 is_a: UBERON:0000025 ! tube
 is_a: UBERON:0000058 ! duct
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: channel_for UBERON:0001827 ! secretion of lacrimal gland
 relationship: connects UBERON:0001351 ! lacrimal sac
 relationship: connects UBERON:0001707 ! nasal cavity
@@ -93772,8 +94742,8 @@ xref: NCIT:C12500
 xref: UMLS:C0015183 {source="ncithesaurus:Eustachian_Tube"}
 xref: VHOG:0001145
 xref: XAO:0000213
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0000062 {source="FMA"} ! organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: has_developmental_contribution_from UBERON:0010020 {source="UBERON:0010062"} ! tubotympanic recess epithelium
 relationship: has_part UBERON:0010062 ! pharyngotympanic tube epithelium
 relationship: part_of UBERON:0001756 ! middle ear
@@ -96891,6 +97861,7 @@ xref: NCIT:C32336
 xref: UMLS:C0931689 {source="ncithesaurus:Cochlear_Labyrinth"}
 is_a: UBERON:0000064 ! organ part
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: located_in UBERON:0001844 ! cochlea
 relationship: part_of UBERON:0001849 {source="FMA"} ! membranous labyrinth
 
@@ -97017,6 +97988,7 @@ xref: MA:0002824
 is_a: UBERON:0001637 ! artery
 is_a: UBERON:0003496 ! head blood vessel
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: branching_part_of UBERON:0018231 ! labyrinthine artery
 relationship: located_in UBERON:0006723 ! cochlear modiolus
 relationship: part_of UBERON:0001846 ! internal ear
@@ -97331,6 +98303,7 @@ xref: VHOG:0001676
 xref: ZFA:0000559
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0006585 ! vestibular organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: capable_of_part_of GO:0060007 ! linear vestibuloocular reflex
 relationship: develops_from UBERON:0003051 ! ear vesicle
 relationship: part_of UBERON:0001862 ! vestibular labyrinth
@@ -97353,6 +98326,7 @@ xref: MESH:D010037
 xref: Otolithic:membrane
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005764 ! acellular membrane
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0005764 ! acellular membrane
 intersection_of: composed_primarily_of UBERON:0002280 ! otolith
 intersection_of: part_of UBERON:0016567 ! statoconial membrane
@@ -98400,8 +99374,8 @@ xref: DMBA:16589
 xref: EMAPA:37921 {source="MA:th"}
 xref: FMA:72405
 xref: HBA:9086
-xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=472 {source="BIRNLEX:1037"}
 xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=472
+xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=472 {source="BIRNLEX:1037"}
 xref: http://en.wikipedia.org/wiki/Olivary_pretectal_nucleus
 xref: http://linkedlifedata.com/resource/umls/id/C0175359
 xref: MBA:706
@@ -104838,6 +105812,7 @@ xref: UMLS:C0458765 {source="BIRNLEX:2555"}
 xref: UMLS:C1184827 {source="BIRNLEX:2523"}
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005913 ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: capable_of_part_of GO:0019230 {source="Wikipedia"} ! proprioception
 relationship: part_of UBERON:0006106 ! cochlear canal
 
@@ -110208,6 +111183,7 @@ xref: ZFA:0000051
 is_a: UBERON:0005291 ! embryonic tissue
 is_a: UBERON:0006598 ! presumptive structure
 is_a: UBERON:0007499 ! epithelial sac
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0010371 ! ecto-epithelium
 intersection_of: UBERON:0007499 ! epithelial sac
 intersection_of: has_potential_to_develop_into UBERON:0001846 ! internal ear
@@ -110246,7 +111222,6 @@ xref: ZFA:0000042
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0007651 {inconsistent_with="ZFA", source="https://sourceforge.net/p/obo/zebrafish-anatomy-zfa-term-requests/106/"} ! anatomical junction
 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
-relationship: develops_from UBERON:0003075 ! neural plate
 relationship: develops_from UBERON:0009615 ! midbrain hindbrain boundary neural plate
 relationship: immediate_transformation_of UBERON:0009615 {source="ZFA"} ! midbrain hindbrain boundary neural plate
 relationship: part_of UBERON:0000955 {source="ZFA"} ! brain
@@ -110383,7 +111358,6 @@ xref: XAO:0000056
 xref: ZFA:0000031
 is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0000479 ! tissue
-relationship: develops_from UBERON:0000922 ! embryo
 relationship: develops_from UBERON:0006599 ! presumptive hypochord
 relationship: immediate_transformation_of UBERON:0006599 {source="Bgee:AN"} ! presumptive hypochord
 relationship: only_in_taxon NCBITaxon:7711 ! Chordata
@@ -110896,9 +111870,7 @@ is_a: UBERON:0010371 ! ecto-epithelium
 is_a: UBERON:0016879 ! future central nervous system
 disjoint_from: UBERON:0011669 ! neural plate of carapace
 relationship: developmentally_induced_by UBERON:0002328 {source="Wikipedia"} ! notochord
-relationship: develops_from UBERON:0004734 ! gastrula
 relationship: develops_from UBERON:0007284 ! presumptive neural plate
-relationship: develops_from UBERON:0016880 ! future nervous system
 relationship: immediate_transformation_of UBERON:0007284 {source="Bgee:AN"} ! presumptive neural plate
 relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
 
@@ -110943,7 +111915,6 @@ xref: ZFA:0000255
 is_a: UBERON:0005291 ! embryonic tissue
 is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue
 is_a: UBERON:0015212 ! lateral structure
-relationship: develops_from UBERON:0000307 ! blastula
 relationship: develops_from UBERON:0007285 ! presumptive paraxial mesoderm
 relationship: existence_starts_during UBERON:0000109 ! gastrula stage
 relationship: immediate_transformation_of UBERON:0007285 {source="Bgee:AN"} ! presumptive paraxial mesoderm
@@ -113133,6 +114104,7 @@ xref: UMLS:C0447640 {source="BIRNLEX:941"}
 xref: VHOG:0001180
 is_a: UBERON:0002616 ! regional part of brain
 is_a: UBERON:0004120 ! mesoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: develops_from UBERON:0006250 {source="MP-def"} ! infundibular recess of 3rd ventricle
 relationship: part_of UBERON:0002198 ! neurohypophysis
 
@@ -113329,8 +114301,7 @@ xref: EHDAA:5155
 xref: EHDAA:6180
 xref: EMAPA:17491
 xref: VHOG:0000779
-is_a: CARO:0000000 ! anatomical entity
-is_a: UBERON:0000483 ! epithelium
+is_a: UBERON:0010371 ! ecto-epithelium
 intersection_of: UBERON:0000483 ! epithelium
 intersection_of: part_of UBERON:0001464 ! hip
 relationship: develops_from UBERON:0003371 {source="EHDAA2"} ! pelvic appendage bud ectoderm
@@ -113348,8 +114319,7 @@ xref: EHDAA:5161
 xref: EHDAA:6186
 xref: EMAPA:17494
 xref: VHOG:0000810
-is_a: CARO:0000000 ! anatomical entity
-is_a: UBERON:0000483 ! epithelium
+is_a: UBERON:0010371 ! ecto-epithelium
 intersection_of: UBERON:0000483 ! epithelium
 intersection_of: part_of UBERON:0001465 ! knee
 relationship: develops_from UBERON:0003371 {source="EHDAA2"} ! pelvic appendage bud ectoderm
@@ -114330,9 +115300,6 @@ xref: VHOG:0000011
 is_a: UBERON:0003547 ! brain meninx
 intersection_of: UBERON:0002360 ! meninx
 intersection_of: part_of UBERON:0002028 ! hindbrain
-relationship: develops_from NCBITaxon:6072 ! Eumetazoa
-relationship: develops_from UBERON:0000955 ! brain
-relationship: develops_from UBERON:0002028 ! hindbrain
 relationship: develops_from UBERON:0010091 ! future hindbrain meninx
 relationship: immediate_transformation_of UBERON:0010091 {evidence="definitional"} ! future hindbrain meninx
 relationship: part_of UBERON:0002028 ! hindbrain
@@ -114963,6 +115930,7 @@ xref: EHDAA:8031
 xref: EMAPA:17929
 xref: VHOG:0001099
 is_a: UBERON:0009891 ! facial mesenchyme
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0034995 ! jaw mesenchyme
 intersection_of: UBERON:0003104 ! mesenchyme
 intersection_of: part_of UBERON:0001709 ! upper jaw region
@@ -115008,8 +115976,8 @@ xref: EHDAA2:0001469
 xref: EHDAA:8981
 xref: EMAPA:17591
 xref: VHOG:0000747
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0005253 ! head mesenchyme
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0003104 ! mesenchyme
 intersection_of: part_of UBERON:0001757 ! pinna
 relationship: part_of UBERON:0001757 ! pinna
@@ -115488,8 +116456,8 @@ synonym: "incisor tooth epithelial tissue" EXACT [OBOL:automatic]
 synonym: "incisor tooth epithelium" EXACT [OBOL:automatic]
 xref: EMAPA:32890
 xref: MA:0003223
-is_a: UBERON:0000483 ! epithelium
 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
+is_a: UBERON:0010371 ! ecto-epithelium
 intersection_of: UBERON:0000483 ! epithelium
 intersection_of: part_of UBERON:0001098 ! incisor tooth
 relationship: part_of UBERON:0001098 ! incisor tooth
@@ -115700,6 +116668,7 @@ xref: FMA:301283
 xref: MA:0001328
 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
 is_a: UBERON:0005911 ! endo-epithelium
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0019306 ! nose epithelium
 intersection_of: UBERON:0000483 ! epithelium
 intersection_of: part_of UBERON:0002255 ! vomeronasal organ
@@ -115750,9 +116719,9 @@ synonym: "pelvic fin bud ectoderm" NARROW SENSU []
 xref: EHDAA2:0001034
 xref: EMAPA:16780
 xref: VHOG:0001048
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0000490 ! unilaminar epithelium
 is_a: UBERON:0005291 ! embryonic tissue
+is_a: UBERON:0010371 ! ecto-epithelium
 intersection_of: UBERON:0000490 ! unilaminar epithelium
 intersection_of: bounding_layer_of UBERON:0005420 ! pelvic appendage bud
 relationship: bounding_layer_of UBERON:0005420 ! pelvic appendage bud
@@ -121680,6 +122649,7 @@ xref: MESH:A14.254.900.710
 xref: NCIT:C32375
 xref: UMLS:C0226993 {source="ncithesaurus:Corona_Dentis"}
 is_a: UBERON:0000063 ! organ subunit
+is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001091 ! calcareous tooth
 
@@ -121720,6 +122690,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/245728004
 xref: MESH:A14.254.900.750
 is_a: CARO:0000003
 is_a: UBERON:0000063 ! organ subunit
+is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: attaches_to UBERON:0001091 ! calcareous tooth
 relationship: part_of RO:0002577 ! system
@@ -122301,7 +123272,7 @@ xref: MESH:D013704
 xref: NCIT:C32888
 xref: Temporomandibular:joint
 xref: UMLS:C0039493 {source="ncithesaurus:Jaw_Joint"}
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011171 ! joint connecting upper and lower jaws
 is_a: UBERON:0015212 ! lateral structure
 intersection_of: UBERON:0000982 ! skeletal joint
@@ -122479,6 +123450,7 @@ xref: NCIT:C33557
 xref: UMLS:C0503361 {source="ncithesaurus:Sinus_of_Valsava"}
 is_a: UBERON:0000064 ! organ part
 is_a: UBERON:0004120 ! mesoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: contributes_to_morphology_of UBERON:0010172 ! bulb of aorta
 relationship: part_of UBERON:0010172 {source="FMA", source="MP"} ! bulb of aorta
 
@@ -124627,7 +125599,6 @@ is_a: UBERON:0001781 ! layer of retina
 intersection_of: UBERON:0001781 ! layer of retina
 intersection_of: immediate_transformation_of UBERON:0005425 ! presumptive neural retina
 relationship: developmentally_induced_by UBERON:0005426 ! lens vesicle
-relationship: develops_from NCBITaxon:6072 ! Eumetazoa
 relationship: develops_from UBERON:0005425 ! presumptive neural retina
 relationship: has_part CL:0000210 ! photoreceptor cell
 relationship: has_part CL:0000540 ! neuron
@@ -125628,11 +126599,6 @@ xref: FMA:6965
 xref: http://www.snomedbrowser.com/Codes/Details/280364004
 xref: Pterygopalatine:ganglion
 is_a: UBERON:0001808 ! parasympathetic ganglion
-relationship: develops_from RO:0002577 ! system
-relationship: develops_from UBERON:0000010 ! peripheral nervous system
-relationship: develops_from UBERON:0000011 ! parasympathetic nervous system
-relationship: develops_from UBERON:0001016 ! nervous system
-relationship: develops_from UBERON:0002410 ! autonomic nervous system
 relationship: develops_from UBERON:0010128 ! future pterygopalatine ganglion
 relationship: immediate_transformation_of UBERON:0010128 {evidence="definitional"} ! future pterygopalatine ganglion
 
@@ -125831,6 +126797,7 @@ xref: FMA:77825
 xref: http://www.snomedbrowser.com/Codes/Details/279829002
 is_a: UBERON:0000025 ! tube
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: connects UBERON:0001854 ! saccule of membranous labyrinth
 relationship: connects UBERON:0001860 ! endolymphatic duct
 relationship: part_of UBERON:0011774 ! utriculosaccular duct
@@ -125847,6 +126814,7 @@ xref: FMA:77824
 xref: http://www.snomedbrowser.com/Codes/Details/279819009
 is_a: UBERON:0000025 ! tube
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: connects UBERON:0001853 ! utricle of membranous labyrinth
 relationship: connects UBERON:0001860 ! endolymphatic duct
 relationship: part_of UBERON:0011774 ! utriculosaccular duct
@@ -125872,6 +126840,7 @@ def: "The utriculo-endolymphatic (UE) valve which is located in the antero-infer
 subset: pheno_slim
 is_a: UBERON:0003978 ! valve
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: contributes_to_morphology_of UBERON:0001853 ! utricle of membranous labyrinth
 relationship: part_of UBERON:0001853 ! utricle of membranous labyrinth
 
@@ -126878,6 +127847,7 @@ xref: MA:0002770
 xref: Osseous:ampullae
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0010000 ! multicellular anatomical structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001840 ! semicircular canal
 relationship: part_of UBERON:0001856 {source="MA"} ! semicircular duct
 
@@ -127143,8 +128113,6 @@ is_a: UBERON:0005291 ! embryonic tissue
 is_a: UBERON:0010371 ! ecto-epithelium
 is_a: UBERON:0034706 {source="NCBIBook:NBK10047"} ! proliferating neuroepithelium
 relationship: adjacent_to UBERON:0003842 ! neural tube lumen
-relationship: develops_from UBERON:0001016 ! nervous system
-relationship: develops_from UBERON:0001049 ! neural tube
 relationship: develops_from UBERON:0004022 ! germinal neuroepithelium
 relationship: immediate_transformation_of UBERON:0004022 {source="NCBIBook:NBK10047"} ! germinal neuroepithelium
 relationship: part_of UBERON:0001049 ! neural tube
@@ -128525,7 +129493,6 @@ xref: ZFA:0000360
 is_a: UBERON:0003914 ! epithelial tube
 is_a: UBERON:0005291 ! embryonic tissue
 is_a: UBERON:0012275 ! meso-epithelium
-relationship: develops_from NCBITaxon:6072 ! Eumetazoa
 relationship: develops_from UBERON:0005498 ! primitive heart tube
 relationship: immediate_transformation_of UBERON:0005498 {source="ZFA-modified"} ! primitive heart tube
 relationship: part_of UBERON:0000922 ! embryo
@@ -128774,6 +129741,7 @@ xref: XAO:0004325
 is_a: CARO:0000003
 is_a: UBERON:0001630 ! muscle organ
 is_a: UBERON:0004120 ! mesoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: composed_primarily_of UBERON:0001134 ! skeletal muscle tissue
 relationship: develops_from UBERON:0010360 {source="http://www.ncbi.nlm.nih.gov/pubmed/21610022"} ! pharyngeal arch mesenchyme from head mesenchyme
 relationship: innervated_by UBERON:0001785 {source="ISBN:0073040584"} ! cranial nerve
@@ -136071,6 +137039,7 @@ xref: AAO:0010143
 xref: http://www.snomedbrowser.com/Codes/Details/361515007
 xref: VHOG:0000854
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0010363 ! endochondral element
 relationship: part_of UBERON:0001703 ! neurocranium
 relationship: part_of UBERON:0001846 ! internal ear
@@ -136634,8 +137603,8 @@ xref: http://www.snomedbrowser.com/Codes/Details/278228007
 xref: MA:0002939
 xref: VHOG:0000927
 is_a: UBERON:0000158 ! membranous layer
-is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005983 ! heart layer
+is_a: UBERON:0010313 ! neural crest-derived structure
 intersection_of: UBERON:0000158 ! membranous layer
 intersection_of: part_of UBERON:0002094 ! interventricular septum
 relationship: contributes_to_morphology_of UBERON:0002094 ! interventricular septum
@@ -137805,6 +138774,7 @@ xref: NCIT:C32063
 xref: UMLS:C0229465 {source="ncithesaurus:Ampullary_Crest"}
 is_a: UBERON:0000020 ! sense organ
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: contributes_to_morphology_of UBERON:0004043 ! semicircular canal ampulla
 relationship: part_of UBERON:0004043 {source="MA"} ! semicircular canal ampulla
 
@@ -138322,6 +139292,7 @@ xref: TAO:0000575
 xref: ZFA:0000575
 is_a: UBERON:0002513 ! endochondral bone
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011164 ! neurocranium bone
 relationship: develops_from UBERON:0004637 ! otic capsule
 relationship: develops_from UBERON:0005410 ! cartilaginous otic capsule
@@ -138344,6 +139315,7 @@ xref: TAO:0000595
 xref: VHOG:0001150
 xref: ZFA:0000595
 is_a: UBERON:0002513 ! endochondral bone
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011164 ! neurocranium bone
 is_a: UBERON:0015015 ! supraoccipital endochondral element
 intersection_of: UBERON:0015015 ! supraoccipital endochondral element
@@ -139743,6 +140715,7 @@ synonym: "epithelium of lacrimal gland" EXACT [OBOL:automatic]
 synonym: "lacrimal gland epithelial tissue" EXACT [OBOL:automatic]
 xref: EMAPA:36515
 xref: MA:0001297
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0015808 ! eye epithelium
 intersection_of: UBERON:0000483 ! epithelium
 intersection_of: part_of UBERON:0001817 ! lacrimal gland
@@ -143374,6 +144347,7 @@ synonym: "organ mucosa of nasolacrimal duct" EXACT [OBOL:automatic]
 xref: FMA:59664
 is_a: UBERON:0000344 ! mucosa
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0000344 ! mucosa
 intersection_of: part_of UBERON:0002392 ! nasolacrimal duct
 relationship: part_of UBERON:0002392 ! nasolacrimal duct
@@ -144258,10 +145232,8 @@ is_a: UBERON:0001285 ! nephron
 is_a: UBERON:0004120 ! mesoderm-derived structure
 intersection_of: UBERON:0001285 ! nephron
 intersection_of: part_of UBERON:0000081 ! metanephros
-relationship: develops_from UBERON:0000081 ! metanephros
 relationship: develops_from UBERON:0003220 {source="http://en.wikipedia.org/wiki/Nephron"} ! metanephric mesenchyme
 relationship: develops_from UBERON:0003220 {source="Wikipedia"} ! metanephric mesenchyme
-relationship: develops_from UBERON:0005113 ! metanephric cortex mesenchyme
 relationship: develops_from UBERON:0010535 ! primitive metanephric nephron
 relationship: immediate_transformation_of UBERON:0010535 {source="Bgee:AN"} ! primitive metanephric nephron
 relationship: part_of UBERON:0000081 ! metanephros
@@ -145589,8 +146561,7 @@ def: "An epithelium that is part of a hindlimb stylopod [Automatically generated
 xref: EHDAA2:0002131
 xref: EMAPA:17500
 xref: VHOG:0001041
-is_a: CARO:0000000 ! anatomical entity
-is_a: UBERON:0000483 ! epithelium
+is_a: UBERON:0010371 ! ecto-epithelium
 intersection_of: UBERON:0000483 ! epithelium
 intersection_of: part_of UBERON:0000376 ! hindlimb stylopod
 relationship: develops_from UBERON:0003371 {source="EHDAA2"} ! pelvic appendage bud ectoderm
@@ -145649,8 +146620,7 @@ def: "An epithelium that is part of a lower leg [Automatically generated definit
 xref: EHDAA2:0001031
 xref: EMAPA:17497
 xref: VHOG:0001050
-is_a: CARO:0000000 ! anatomical entity
-is_a: UBERON:0000483 ! epithelium
+is_a: UBERON:0010371 ! ecto-epithelium
 intersection_of: UBERON:0000483 ! epithelium
 intersection_of: part_of UBERON:0003823 ! hindlimb zeugopod
 relationship: develops_from UBERON:0003371 {source="EHDAA2"} ! pelvic appendage bud ectoderm
@@ -145722,6 +146692,7 @@ xref: VHOG:0001220
 xref: XAO:0000199
 is_a: UBERON:0000064 ! organ part
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: contributes_to_morphology_of UBERON:0001846 ! internal ear
 relationship: part_of UBERON:0001839 ! bony labyrinth
 
@@ -146308,6 +147279,7 @@ xref: TAO:0005157
 xref: ZFA:0005157
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005283 ! tela choroidea
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0005283 ! tela choroidea
 intersection_of: part_of UBERON:0002289 ! midbrain cerebral aqueduct
 relationship: part_of UBERON:0002289 ! midbrain cerebral aqueduct
@@ -146405,11 +147377,6 @@ xref: http://en.wikipedia.org/wiki/Myelencephalon
 xref: MA:0000205
 xref: VHOG:0000456
 is_a: UBERON:0004733 ! segmental subdivision of hindbrain
-relationship: develops_from NCBITaxon:6072 ! Eumetazoa
-relationship: develops_from UBERON:0000955 ! brain
-relationship: develops_from UBERON:0001016 ! nervous system
-relationship: develops_from UBERON:0001017 ! central nervous system
-relationship: develops_from UBERON:0002028 ! hindbrain
 relationship: develops_from UBERON:0010096 ! future myelencephalon
 relationship: dubious_for_taxon NCBITaxon:7955 ! Danio rerio
 relationship: immediate_transformation_of UBERON:0010096 {evidence="definitional"} ! future myelencephalon
@@ -146561,8 +147528,6 @@ is_a: UBERON:0004910 ! epithelium of male gonad
 is_a: UBERON:0005295 ! sex cord
 intersection_of: UBERON:0005295 ! sex cord
 intersection_of: part_of UBERON:0000473 ! testis
-relationship: develops_from UBERON:0000990 ! reproductive system
-relationship: develops_from UBERON:0009196 ! indifferent external genitalia
 relationship: develops_from UBERON:0010141 ! primitive sex cord of indifferent gonad
 relationship: immediate_transformation_of UBERON:0010141 {source="Bgee:AN"} ! primitive sex cord of indifferent gonad
 relationship: part_of UBERON:0000473 ! testis
@@ -147534,8 +148499,8 @@ synonym: "inferior ganglion of glossopharyngeal nerve" EXACT [FMA:53475]
 synonym: "inferior glossopharyngeal ganglion" EXACT [FMA:53475]
 synonym: "inferior glossopharyngeal ganglion of the glossopharyngeal (IX) nerve" EXACT [MP:0001084]
 synonym: "ninth cranial nerve inferior ganglion" EXACT [FMA:53475]
-synonym: "petrosal ganglion" RELATED [MP:0001084]
 synonym: "petrosal ganglion" RELATED [http://www.merriam-webster.com/medical/petrosal%20ganglion, MP:0001084]
+synonym: "petrosal ganglion" RELATED [MP:0001084]
 synonym: "petrous ganglion" RELATED [http://en.wikipedia.org/wiki/File\:Gray791.png, http://en.wikipedia.org/wiki/Inferior_ganglion_of_glossopharyngeal_nerve, http://www.merriam-webster.com/medical/petrous%20ganglion]
 xref: EHDAA2:0000711
 xref: EMAPA:17153
@@ -151224,6 +152189,7 @@ xref: MA:0001210
 xref: VHOG:0001344
 is_a: UBERON:0000025 ! tube
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001856 ! semicircular duct
 
 [Term]
@@ -153110,6 +154076,7 @@ xref: EHDAA:5707
 xref: http://www.snomedbrowser.com/Codes/Details/343518007
 is_a: UBERON:0000476 {inconsistent_with="MP-def", source="EHDAA2"} ! acellular anatomical structure
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: develops_from UBERON:0003902 {source="EHDAA2"} ! retinal neural layer
 relationship: located_in UBERON:0005606 {source="EHDAA2"} ! hyaloid cavity
 relationship: part_of UBERON:0008816 {source="cjm"} ! embryonic head
@@ -155147,6 +156114,7 @@ name: blood-inner ear barrier
 def: "The function of the group of barriers and transport systems which regulate the transport of various substances from blood to inner ear tissue and maintain the microhomeostasis and functional integrity of the inner ear; the endothelial cells of the inner ear blood capillaries, linked to each other by tight junctions, represent the main component of the blood-inner ear barrier." [MP:0004999]
 is_a: UBERON:0003496 ! head blood vessel
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001846 ! internal ear
 
 [Term]
@@ -157067,6 +158035,7 @@ xref: UMLS:C0009198 {source="BIRNLEX:2553"}
 xref: UMLS:C0458767 {source="BIRNLEX:2553"}
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005913 ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001844 ! cochlea
 
 [Term]
@@ -157938,8 +158907,8 @@ xref: EHDAA2:0000136
 xref: EHDAA:2592
 xref: EMAPA:16827
 xref: VHOG:0000502
-is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0004142 ! outflow tract septum
+is_a: UBERON:0010313 ! neural crest-derived structure
 intersection_of: UBERON:0002099 ! cardiac septum
 intersection_of: adjacent_to UBERON:0002333 ! pulmonary trunk
 intersection_of: adjacent_to UBERON:0005805 ! dorsal aorta
@@ -157978,6 +158947,7 @@ xref: VHOG:0001124
 is_a: UBERON:0003932 ! cartilage element of chondrocranium
 is_a: UBERON:0005253 ! head mesenchyme
 is_a: UBERON:0005863 ! cartilaginous condensation
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0015048 ! basioccipital endochondral element
 intersection_of: UBERON:0015048 ! basioccipital endochondral element
 intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue
@@ -158630,6 +159600,7 @@ xref: Infundibular:recess
 is_a: UBERON:0002050 ! embryonic structure
 is_a: UBERON:0005291 ! embryonic tissue
 is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0010371 ! ecto-epithelium
 is_a: UBERON:0012275 ! meso-epithelium
 relationship: develops_from UBERON:0003309 {source="EHDAA2"} ! floor plate of diencephalon
@@ -158812,7 +159783,6 @@ xref: EHDAA2:0001055
 xref: EHDAA:9026
 xref: EMAPA:17826
 xref: VHOG:0000958
-is_a: UBERON:0010313 ! neural crest-derived structure
 is_a: UBERON:0015018 ! malleus endochondral element
 is_a: UBERON:0035132 ! auditory ossicle pre-cartilage element
 intersection_of: UBERON:0015018 ! malleus endochondral element
@@ -158884,6 +159854,7 @@ xref: UMLS:C1513875 {source="ncithesaurus:Nasolacrimal_Groove"}
 xref: VHOG:0001307
 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
 is_a: UBERON:0005291 ! embryonic tissue
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0019306 ! nose epithelium
 relationship: adjacent_to UBERON:0004067 ! lateral nasal prominence
 relationship: adjacent_to UBERON:0005868 ! maxillary prominence
@@ -161333,6 +162304,7 @@ xref: EMAPA:35621
 xref: FMA:75666
 xref: MA:0001183
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0013685 ! foramen of skull
 relationship: part_of UBERON:0007223 {source="MA"} ! osseus cochlea
 
@@ -161347,6 +162319,7 @@ xref: EMAPA:37526 {source="MA:th"}
 xref: FMA:61290
 xref: MA:0001235
 is_a: UBERON:0004119 ! endoderm-derived structure
+is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0034921 ! multi organ part structure
 relationship: part_of UBERON:0001352 ! external acoustic meatus
 
@@ -162136,11 +163109,7 @@ is_a: UBERON:0004120 ! mesoderm-derived structure
 is_a: UBERON:0006590 ! remnant of embryonic structure
 intersection_of: UBERON:0006590 ! remnant of embryonic structure
 intersection_of: immediate_transformation_of UBERON:0001637 ! artery
-relationship: develops_from UBERON:0001009 ! circulatory system
 relationship: develops_from UBERON:0001637 ! artery
-relationship: develops_from UBERON:0004535 ! cardiovascular system
-relationship: develops_from UBERON:0004537 ! blood vasculature
-relationship: develops_from UBERON:0004572 ! arterial system
 relationship: immediate_transformation_of UBERON:0001637 ! artery
 
 [Term]
@@ -162152,11 +163121,7 @@ is_a: UBERON:0004120 ! mesoderm-derived structure
 is_a: UBERON:0006590 ! remnant of embryonic structure
 intersection_of: UBERON:0006590 ! remnant of embryonic structure
 intersection_of: immediate_transformation_of UBERON:0001638 ! vein
-relationship: develops_from UBERON:0001009 ! circulatory system
 relationship: develops_from UBERON:0001638 ! vein
-relationship: develops_from UBERON:0004535 ! cardiovascular system
-relationship: develops_from UBERON:0004537 ! blood vasculature
-relationship: develops_from UBERON:0004582 ! venous system
 relationship: immediate_transformation_of UBERON:0001638 ! vein
 
 [Term]
@@ -162360,6 +163325,7 @@ xref: Symphysis:menti
 xref: TAO:0001851
 xref: ZFA:0005488
 is_a: UBERON:0002216 {source="FMA"} ! symphysis
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0002213 ! cartilaginous joint
 intersection_of: connects UBERON:0004742 {minCardinality="2", maxCardinality="2"} ! dentary
 relationship: connects UBERON:0004742 {notes="connects adjacent mandibles"} ! dentary
@@ -162708,14 +163674,7 @@ xref: http://en.wikipedia.org/wiki/Median_umbilical_ligament
 xref: http://www.snomedbrowser.com/Codes/Details/89583000
 is_a: UBERON:0004120 ! mesoderm-derived structure
 is_a: UBERON:0006590 {source="FMA"} ! remnant of embryonic structure
-relationship: develops_from NCBITaxon:6072 ! Eumetazoa
-relationship: develops_from UBERON:0001008 ! renal system
-relationship: develops_from UBERON:0001255 ! urinary bladder
-relationship: develops_from UBERON:0001556 ! lower urinary tract
 relationship: develops_from UBERON:0002068 ! urachus
-relationship: develops_from UBERON:0002100 ! trunk
-relationship: develops_from UBERON:0013701 ! main body axis
-relationship: develops_from UBERON:0013702 ! body proper
 relationship: immediate_transformation_of UBERON:0002068 ! urachus
 relationship: part_of UBERON:0000916 ! abdomen
 
@@ -163317,8 +164276,8 @@ synonym: "canales alveolares maxillae" RELATED LATIN [http://en.wikipedia.org/wi
 xref: Alveolar:canals
 xref: EMAPA:25099
 xref: FMA:57743
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0005744 ! bone foramen
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: conduit_for UBERON:0018397 ! posterior superior alveolar artery
 relationship: conduit_for UBERON:0018401 ! posterior superior alveolar nerve
 relationship: part_of UBERON:0001710 {source="EMAPA"} ! lower jaw region
@@ -163344,7 +164303,6 @@ is_a: UBERON:0000043 ! tendon
 is_a: UBERON:0003570 ! respiratory system connective tissue
 is_a: UBERON:0003837 ! thoracic segment connective tissue
 relationship: attaches_to UBERON:0002359 ! fibrous pericardium
-relationship: develops_from UBERON:0002204 ! musculoskeletal system
 relationship: develops_from UBERON:0006239 ! future central tendon
 relationship: immediate_transformation_of UBERON:0006239 {evidence="definitional"} ! future central tendon
 relationship: part_of RO:0002577 ! system
@@ -163854,12 +164812,9 @@ xref: http://www.snomedbrowser.com/Codes/Details/368738001
 xref: MA:0000725
 is_a: UBERON:0004119 ! endoderm-derived structure
 is_a: UBERON:0005160 ! vestigial structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 disjoint_from: UBERON:0006713 ! foramen cecum of frontal bone
-relationship: develops_from UBERON:0000949 ! endocrine system
-relationship: develops_from UBERON:0001004 ! respiratory system
-relationship: develops_from UBERON:0001042 ! chordate pharynx
 relationship: develops_from UBERON:0001761 ! future foramen cecum
-relationship: develops_from UBERON:0003091 ! thyroid primordium
 relationship: immediate_transformation_of UBERON:0001761 ! future foramen cecum
 relationship: part_of UBERON:0003357 {source="EHDAA2"} ! epithelium of tongue
 relationship: part_of UBERON:0009471 ! dorsum of tongue
@@ -164114,6 +165069,7 @@ xref: NCIT:C33135
 xref: UMLS:C0229503 {source="ncithesaurus:Modiolus"}
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005913 ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 disjoint_from: UBERON:0011386 ! facial modiolus
 relationship: contributes_to_morphology_of UBERON:0001844 ! cochlea
 relationship: part_of UBERON:0007223 {source="MA"} ! osseus cochlea
@@ -164137,6 +165093,7 @@ xref: MA:0001184
 xref: MESH:D013137
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005913 ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0006723 {source="FMA"} ! cochlear modiolus
 relationship: part_of UBERON:0007223 {source="MA"} ! osseus cochlea
 
@@ -164161,6 +165118,7 @@ xref: Spiral:ligament
 is_a: CARO:0000003
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0008845 ! nonskeletal ligament
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: attaches_to UBERON:0006106 {source="MESH-def"} ! cochlear canal
 relationship: has_part CL:0002665 ! otic fibrocyte
 relationship: part_of RO:0002577 ! system
@@ -164424,6 +165382,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/362524000
 xref: ZFA:0005573
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0008841 {source="Obol"} ! suspensory ligament
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: continuous_with UBERON:0000965 ! lens of camera-type eye
 relationship: continuous_with UBERON:0001775 ! ciliary body
 relationship: develops_from UBERON:0001797 {source="ZFA"} ! vitreous humor
@@ -165119,6 +166078,7 @@ xref: AAO:0000330
 xref: Exoccipital:condyle
 xref: FMA:52861
 is_a: UBERON:0005913 ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001693 ! exoccipital bone
 
 [Term]
@@ -165474,6 +166434,7 @@ xref: TAO:0001973
 xref: UMLS:C0226994 {source="ncithesaurus:Tooth_Cusp"}
 xref: ZFA:0005434
 is_a: UBERON:0000476 {source="ZFA"} ! acellular anatomical structure
+is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0003675 {source="FMA"} ! tooth crown
 
@@ -166447,6 +167408,7 @@ def: "The epithelial cell layer containing the sensory hair cells and their asso
 subset: pheno_slim
 xref: EMAPA:32883
 xref: MA:0001189
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0010371 ! ecto-epithelium
 is_a: UBERON:0015807 ! ear epithelium
 intersection_of: UBERON:0000483 ! epithelium
@@ -166461,7 +167423,7 @@ xref: EHDAA2:0001470
 xref: EHDAA:8983
 xref: EMAPA:17592
 xref: VHOG:0000632
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0015814 ! outer ear epithelium
 intersection_of: UBERON:0000483 ! epithelium
 intersection_of: part_of UBERON:0001757 ! pinna
@@ -168456,8 +169418,8 @@ xref: EHDAA2:0002093
 xref: EMAPA:16182
 xref: TAO:0000999
 xref: ZFA:0000999
-is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005256 ! trunk mesenchyme
+is_a: UBERON:0014387 ! mesenchyme derived from neural crest
 intersection_of: UBERON:0003104 ! mesenchyme
 intersection_of: develops_from UBERON:0003083 ! trunk neural crest
 relationship: develops_from UBERON:0003083 ! trunk neural crest
@@ -169599,6 +170561,7 @@ synonym: "choroid plexus tectal ventricles" RELATED PLURAL [ZFA:0001445]
 xref: TAO:0001445
 xref: ZFA:0001445
 is_a: UBERON:0001886 ! choroid plexus
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0001886 ! choroid plexus
 intersection_of: part_of UBERON:0002289 ! midbrain cerebral aqueduct
 relationship: part_of UBERON:0002289 ! midbrain cerebral aqueduct
@@ -169924,6 +170887,7 @@ def: "A rhamphotheca that is part of a lower beak." [OBOL:automatic]
 synonym: "gnathotheca" RELATED [http://en.wikipedia.org/wiki/Beak#Rhamphotheca]
 synonym: "mandibular beak" RELATED []
 is_a: UBERON:0007330 ! rhamphotheca
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0007330 ! rhamphotheca
 intersection_of: part_of UBERON:0010013 ! lower beak
 relationship: part_of UBERON:0010013 ! lower beak
@@ -172901,6 +173865,7 @@ xref: FMA:77849
 xref: MA:0001194
 is_a: UBERON:0001967 ! reticular lamina of epithelium
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0001967 ! reticular lamina of epithelium
 intersection_of: part_of UBERON:0002227 ! spiral organ of cochlea
 relationship: part_of UBERON:0002227 ! spiral organ of cochlea
@@ -173077,6 +174042,7 @@ synonym: "osseous semicircular canal" EXACT [OBOL:automatic]
 xref: MA:0000250
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005913 {notes="checkme"} ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001839 {source="MA"} ! bony labyrinth
 relationship: part_of UBERON:0001840 {source="MA"} ! semicircular canal
 
@@ -173581,6 +174547,7 @@ xref: MESH:D002680
 xref: NCIT:C81169
 xref: TAO:0002254
 is_a: UBERON:0001444 ! subdivision of head
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001456 {source="MESH"} ! face
 relationship: part_of UBERON:0001710 {source="FMA"} ! lower jaw region
 
@@ -176715,6 +177682,7 @@ xref: NCIT:C32723
 xref: UMLS:C0229512 {source="ncithesaurus:Helicotrema"}
 is_a: UBERON:0000161 {source="FMA"} ! orifice
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0002499 {source="Wikipedia"} ! cochlear labyrinth
 
 [Term]
@@ -177615,6 +178583,7 @@ xref: FMA:61035
 xref: http://www.snomedbrowser.com/Codes/Details/362548009
 xref: MA:0001228
 is_a: UBERON:0008846 {source="FMA"} ! skeletal ligament
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001757 {source="MA"} ! pinna
 
 [Term]
@@ -179203,8 +180172,8 @@ id: UBERON:0009029
 name: pudendal vein
 def: "Either the internal or external pudendal vein, running from the genital-vulvar area and abdomen and down the leg." [http://orcid.org/0000-0002-6601-2165, https://veintreatmentcenter.com/vein-information/pudendal-veins/]
 synonym: "pudic vein" RELATED []
-synonym: "vena pudendae" EXACT DEPRECATED [https://doi.org/10.1002/ca.23705]
 synonym: "vena pudendae" EXACT LATIN [https://doi.org/10.1002/ca.23705]
+synonym: "vena pudendae" EXACT DEPRECATED [https://doi.org/10.1002/ca.23705]
 synonym: "vena pudendales" EXACT LATIN [https://doi.org/10.1002/ca.23705]
 xref: EMAPA:37184 {source="MA:th"}
 xref: http://www.snomedbrowser.com/Codes/Details/395225000
@@ -180024,6 +180993,7 @@ is_a: UBERON:0000487 ! simple squamous epithelium
 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
 is_a: UBERON:0002166 ! endocardium of atrium
 is_a: UBERON:0005291 ! embryonic tissue
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0012275 ! meso-epithelium
 intersection_of: UBERON:0002165 ! endocardium
 intersection_of: part_of UBERON:0002078 ! right cardiac atrium
@@ -180960,9 +181930,9 @@ synonym: "mesenchyme of maxillary prominence" EXACT [https://orcid.org/0000-0002
 xref: EHDAA2:0001071
 xref: EMAPA:17361
 xref: FMA:312691
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0003104 ! mesenchyme
 is_a: UBERON:0005291 ! embryonic tissue
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0003104 ! mesenchyme
 intersection_of: part_of UBERON:0005868 ! maxillary prominence
 relationship: part_of UBERON:0005868 ! maxillary prominence
@@ -181758,7 +182728,6 @@ synonym: "midbrain-hindbrain boundary neural plate" EXACT [ZFA:0007044]
 xref: TAO:0007044
 xref: ZFA:0007044
 is_a: UBERON:0006598 ! presumptive structure
-relationship: develops_from UBERON:0006238 ! future brain
 relationship: develops_from UBERON:0007281 ! presumptive midbrain hindbrain boundary
 relationship: immediate_transformation_of UBERON:0007281 {notes="https://github.com/obophenotype/uberon/issues/438", source="Bgee:AN"} ! presumptive midbrain hindbrain boundary
 relationship: part_of UBERON:0003075 {source="ZFA"} ! neural plate
@@ -182457,6 +183426,7 @@ xref: FMA:295942
 is_a: UBERON:0000481 {source="EHDAA2"} ! multi-tissue structure
 is_a: UBERON:0004119 ! endoderm-derived structure
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: develops_from UBERON:0009671 {notes="posterior portion", source="EHDAA2"} ! nasal fin
 relationship: part_of UBERON:0000166 {source="EHDAA2"} ! oral opening
 relationship: part_of UBERON:0005384 {source="EHDAA2"} ! nasal cavity epithelium
@@ -182730,6 +183700,7 @@ xref: NCIT:C102343
 xref: VHOG:0001235
 is_a: CARO:0000003
 is_a: UBERON:0001081 ! endocardium of ventricle
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0001081 ! endocardium of ventricle
 intersection_of: part_of UBERON:0002080 ! heart right ventricle
 relationship: attaches_to UBERON:0006567 {source="FMA"} ! right ventricle myocardium
@@ -185145,8 +186116,8 @@ name: lower beak
 synonym: "lower mandible" RELATED SENSU []
 synonym: "mandibular beak" RELATED []
 synonym: "rostrum mandibulare" RELATED []
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0003102 ! surface structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001710 ! lower jaw region
 relationship: part_of UBERON:0005094 ! beak
 
@@ -185664,7 +186635,6 @@ id: UBERON:0010054
 name: malleus cartilage element
 def: "A malleus endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic]
 xref: EMAPA:18229
-is_a: UBERON:0010313 ! neural crest-derived structure
 is_a: UBERON:0015018 ! malleus endochondral element
 is_a: UBERON:0035131 ! auditory ossicle cartilage element
 intersection_of: UBERON:0015018 ! malleus endochondral element
@@ -185768,6 +186738,7 @@ xref: FMA:285217
 xref: MA:0003142
 is_a: UBERON:0003914 {source="EHDAA2"} ! epithelial tube
 is_a: UBERON:0005911 ! endo-epithelium
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0015813 ! middle ear epithelium
 relationship: develops_from UBERON:0010020 ! tubotympanic recess epithelium
 relationship: develops_from_part_of UBERON:0010020 {source="EHDAA2"} ! tubotympanic recess epithelium
@@ -185779,6 +186750,7 @@ name: tympanic cavity epithelium
 xref: EHDAA2:0004116
 is_a: UBERON:0005911 ! endo-epithelium
 is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0015813 ! middle ear epithelium
 relationship: develops_from UBERON:0010020 ! tubotympanic recess epithelium
 relationship: develops_from_part_of UBERON:0010020 {source="EHDAA2"} ! tubotympanic recess epithelium
@@ -185804,6 +186776,7 @@ name: auditory meatus epithelium
 xref: EHDAA2:0004114
 is_a: UBERON:0003914 {source="EHDAA2"} ! epithelial tube
 is_a: UBERON:0005911 ! endo-epithelium
+is_a: UBERON:0010371 ! ecto-epithelium
 is_a: UBERON:0015814 ! outer ear epithelium
 relationship: develops_from UBERON:0005872 {source="http://www.ncbi.nlm.nih.gov/pubmed/16313389", source="EHDAA2"} ! 1st arch pharyngeal cleft
 relationship: part_of UBERON:0001691 {source="EHDAA2"} ! external ear
@@ -185824,6 +186797,7 @@ xref: FMA:52880
 xref: http://en.wikipedia.org/wiki/Tympanic_part_of_the_temporal_bone
 xref: http://www.snomedbrowser.com/Codes/Details/138773005
 is_a: UBERON:0005913 {source="cjm"} ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: develops_from UBERON:0002218 ! tympanic ring
 relationship: part_of UBERON:0001678 ! temporal bone
 
@@ -185840,6 +186814,7 @@ xref: FMA:56819
 xref: http://www.snomedbrowser.com/Codes/Details/39725007
 is_a: UBERON:0005911 ! endo-epithelium
 is_a: UBERON:0009647 ! tympanic membrane epithelium
+is_a: UBERON:0010371 ! ecto-epithelium
 is_a: UBERON:0015814 ! outer ear epithelium
 intersection_of: UBERON:0009647 ! tympanic membrane epithelium
 intersection_of: part_of UBERON:0001352 ! external acoustic meatus
@@ -185866,8 +186841,8 @@ name: layer of tympanic membrane
 subset: grouping_class
 synonym: "tympanic membrane layer" EXACT [FMA:56732]
 xref: FMA:56732
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0000064 ! organ part
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0002364 ! tympanic membrane
 
 [Term]
@@ -186672,6 +187647,7 @@ xref: FMA:3740
 xref: http://www.snomedbrowser.com/Codes/Details/362032000
 is_a: UBERON:0000064 ! organ part
 is_a: UBERON:0004120 ! mesoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: contributes_to_morphology_of UBERON:0001496 ! ascending aorta
 relationship: part_of UBERON:0001496 {source="FMA"} ! ascending aorta
 
@@ -186684,6 +187660,7 @@ synonym: "sinotubular ridge" EXACT [MP:0011572]
 xref: EMAPA:37951 {source="MA:th"}
 is_a: UBERON:0004120 ! mesoderm-derived structure
 is_a: UBERON:0007651 ! anatomical junction
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: contributes_to_morphology_of UBERON:0001496 ! ascending aorta
 relationship: part_of UBERON:0001496 {source="MP"} ! ascending aorta
 
@@ -188409,7 +189386,6 @@ xref: EHDAA2:0004602
 is_a: UBERON:0003104 {source="EHDAA2"} ! mesenchyme
 is_a: UBERON:0004120 ! mesoderm-derived structure
 is_a: UBERON:0009526 ! maxillary process mesenchyme
-is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0003104 ! mesenchyme
 intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
 intersection_of: part_of UBERON:0009526 ! maxillary process mesenchyme
@@ -191889,6 +192865,7 @@ xref: EMAPA:18339
 is_a: UBERON:0003932 ! cartilage element of chondrocranium
 is_a: UBERON:0005253 ! head mesenchyme
 is_a: UBERON:0005863 ! cartilaginous condensation
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0015051 ! exoccipital endochondral element
 intersection_of: UBERON:0015051 ! exoccipital endochondral element
 intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue
@@ -192539,7 +193516,7 @@ def: "An endochondral element of the nasal capsule that forms septum between nas
 synonym: "mesethmoid" RELATED [AAO:0000303]
 synonym: "ventral nasal capsule" EXACT [http://www.ncbi.nlm.nih.gov/pubmed/21270050]
 xref: AAO:0000303
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0010363 {source="TAO"} ! endochondral element
 relationship: develops_from UBERON:0005945 {source="TAO"} ! neurocranial trabecula
 relationship: dubious_for_taxon NCBITaxon:8292 {editor_note="check AAO"} ! Amphibia
@@ -192728,6 +193705,7 @@ comment: see TAO:0000474 - intercalar "Small membrane bone homologous with a car
 xref: AAO:0010835
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005913 ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0004637 {source="AAO"} ! otic capsule
 
 [Term]
@@ -193868,6 +194846,7 @@ xref: Perilymphatic:duct
 xref: ZFA:0005461
 is_a: UBERON:0000025 ! tube
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001846 {source="MA"} ! internal ear
 relationship: surrounds UBERON:0001845 ! perilymph
 
@@ -194787,6 +195766,7 @@ synonym: "supra-occipital cartilage condensation" EXACT []
 synonym: "supraoccipital cartilage condensation" EXACT [EMAPA:18341]
 xref: EMAPA:18341
 is_a: UBERON:0003932 ! cartilage element of chondrocranium
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0015015 ! supraoccipital endochondral element
 intersection_of: UBERON:0015015 ! supraoccipital endochondral element
 intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue
@@ -195741,6 +196721,7 @@ xref: EFO:0003685
 xref: TAO:0001405
 xref: ZFA:0001405
 is_a: UBERON:0003932 {source="TAO"} ! cartilage element of chondrocranium
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: develops_from UBERON:0005945 {source="ISBN:0073040584"} ! neurocranial trabecula
 relationship: part_of UBERON:0002517 {source="FMA"} ! basicranium
 relationship: part_of UBERON:0011241 {source="AAO"} ! ethmoid region
@@ -196589,6 +197570,7 @@ xref: http://en.wikipedia.org/wiki/Capsule_of_temporomandibular_joint
 xref: http://www.snomedbrowser.com/Codes/Details/303404000
 xref: MFMO:0000046
 is_a: UBERON:0001484 ! articular capsule
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0013765 ! digestive system element
 intersection_of: UBERON:0001484 ! articular capsule
 intersection_of: part_of UBERON:0003700 ! temporomandibular joint
@@ -196615,6 +197597,7 @@ xref: http://en.wikipedia.org/wiki/Articular_disk_of_the_temporomandibular_joint
 xref: http://www.snomedbrowser.com/Codes/Details/282433007
 xref: MESH:D019224
 is_a: UBERON:0007844 {source="FMA"} ! cartilage element
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0013765 ! digestive system element
 relationship: part_of UBERON:0003700 {source="BTO"} ! temporomandibular joint
 
@@ -196626,6 +197609,7 @@ xref: FMA:57070
 xref: http://www.snomedbrowser.com/Codes/Details/127861009
 xref: Ligaments
 is_a: UBERON:0008846 ! skeletal ligament
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0013765 ! digestive system element
 intersection_of: UBERON:0008846 ! skeletal ligament
 intersection_of: part_of UBERON:0003700 ! temporomandibular joint
@@ -197811,6 +198795,7 @@ synonym: "upper jaw future lip" EXACT [EHDAA2:0002120]
 xref: EHDAA2:0002120
 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
 is_a: UBERON:0003235 ! epithelium of upper jaw
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: develops_from UBERON:0004068 {notes="fusion"} ! medial nasal prominence
 relationship: develops_from UBERON:0005868 {notes="fusion"} ! maxillary prominence
 relationship: part_of UBERON:0001709 {source="EHDAA2"} ! upper jaw region
@@ -197910,9 +198895,8 @@ synonym: "processus lenticularis incudis" EXACT LATIN [FMA:52775, FMA:TA]
 xref: FMA:52775
 xref: http://palaeos.com/vertebrates/bones/ear/images/Incus3.gif
 xref: http://www.snomedbrowser.com/Codes/Details/368928003
-is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0004530 ! bony projection
-is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
+is_a: UBERON:0010313 ! neural crest-derived structure
 relationship: develops_from UBERON:0005689 ! 2nd arch mesenchyme
 relationship: part_of UBERON:0001688 {source="FMA"} ! incus bone
 
@@ -197955,6 +198939,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0227123
 xref: http://www.snomedbrowser.com/Codes/Details/304704007
 xref: NCIT:C54204
 is_a: UBERON:0001828 ! gingiva
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0001828 ! gingiva
 intersection_of: part_of UBERON:0001710 ! lower jaw region
 relationship: part_of UBERON:0001710 ! lower jaw region
@@ -199188,6 +200173,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/279811007
 xref: NCIT:C33845
 is_a: UBERON:0000025 ! tube
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0000025 ! tube
 intersection_of: connects UBERON:0001853 ! utricle of membranous labyrinth
 intersection_of: connects UBERON:0001854 ! saccule of membranous labyrinth
@@ -199432,6 +200418,7 @@ name: dermal pulp of feather shaft
 def: "A tissue that is part of a cavity of feather shaft." [OBOL:automatic]
 is_a: UBERON:0000479 ! tissue
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0000479 ! tissue
 intersection_of: part_of UBERON:0011784 ! feather shaft
 relationship: develops_from UBERON:0011803 ! feather bud, dermal component
@@ -199470,6 +200457,7 @@ synonym: "dermal papilla of feather bud" EXACT []
 synonym: "dermal papilla of feather papilla" EXACT []
 is_a: UBERON:0003104 ! mesenchyme
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0003104 ! mesenchyme
 intersection_of: part_of UBERON:0011802 ! feather bud
 relationship: develops_from UBERON:0011801 ! dermal condensation of feather follicle
@@ -199806,6 +200794,7 @@ synonym: "parotid gland acinus" EXACT [FMA:59863]
 xref: EMAPA:37933 {source="MA:th"}
 xref: FMA:59863
 xref: http://www.snomedbrowser.com/Codes/Details/46926004
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011850 ! acinus of salivary gland
 is_a: UBERON:0013232 ! serous acinus
 intersection_of: UBERON:0009842 ! glandular acinus
@@ -199856,6 +200845,7 @@ def: "An acinus that is part of a lacrimal gland." [OBOL:automatic]
 synonym: "lacrimal gland acinus" EXACT [FMA:85250]
 xref: FMA:85250
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011858 ! acinus of exocrine gland
 intersection_of: UBERON:0009842 ! glandular acinus
 intersection_of: part_of UBERON:0001817 ! lacrimal gland
@@ -199890,6 +200880,7 @@ xref: NCIT:C95443
 xref: UMLS:C0149591 {source="ncithesaurus:Internal_Auditory_Canal_of_Ear"}
 is_a: UBERON:0004111 ! anatomical conduit
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: conduit_for UBERON:0001647 ! facial nerve
 relationship: conduit_for UBERON:0001648 ! vestibulocochlear nerve
 relationship: contributes_to_morphology_of UBERON:0001846 ! internal ear
@@ -200464,6 +201455,7 @@ synonym: "cochlea basement membrane" EXACT []
 xref: EMAPA:37830 {source="MA:th"}
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005769 ! basement membrane of epithelium
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0005769 ! basement membrane of epithelium
 intersection_of: part_of UBERON:0002499 ! cochlear labyrinth
 relationship: part_of UBERON:0002499 ! cochlear labyrinth
@@ -202267,7 +203259,7 @@ xref: CALOHA:TS-1079
 xref: Cord:blood
 xref: EFO:0001942
 xref: MESH:D005312
-is_a: UBERON:0000178 ! blood
+is_a: UBERON:0013755 ! arterial blood
 intersection_of: UBERON:0000178 ! blood
 intersection_of: located_in UBERON:0001310 ! umbilical artery
 relationship: located_in UBERON:0001310 ! umbilical artery
@@ -203615,9 +204607,9 @@ name: maxillary process ectoderm
 xref: EHDAA2:0004599
 xref: EMAPA:17637
 xref: FMA:312685
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
 is_a: UBERON:0005291 ! embryonic tissue
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0005868 {source="EHDAA2"} ! maxillary prominence
 
 [Term]
@@ -203628,6 +204620,7 @@ xref: EHDAA2:0000039
 xref: EMAPA:16389
 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
 is_a: UBERON:0005291 ! embryonic tissue
+is_a: UBERON:0010371 ! ecto-epithelium
 is_a: UBERON:0015833 ! foregut epithelium
 relationship: develops_from UBERON:0000076 {source="EHDAA2"} ! external ectoderm
 relationship: part_of UBERON:0000076 {source="EHDAA2"} ! external ectoderm
@@ -206209,6 +207202,7 @@ xref: EHDAA2:0000032
 xref: EMAPA:16383
 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
 is_a: UBERON:0005291 ! embryonic tissue
+is_a: UBERON:0010371 ! ecto-epithelium
 is_a: UBERON:0015833 ! foregut epithelium
 relationship: develops_from UBERON:0000076 {source="EHDAA2"} ! external ectoderm
 relationship: part_of UBERON:0000076 {source="EHDAA2"} ! external ectoderm
@@ -206464,6 +207458,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/368942006
 xref: NCIT:C32117
 xref: UMLS:C1510916 {source="ncithesaurus:Anterior_Wall_of_the_Tympanum"}
 is_a: UBERON:0005913 ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0010066 ! tympanic plate
 
 [Term]
@@ -210401,6 +211396,7 @@ xref: VHOG:0001567
 xref: XAO:0003145
 is_a: UBERON:0000020 ! sense organ
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound
 relationship: has_part CL:0000202 ! auditory hair cell
 relationship: part_of UBERON:0001855 {source="MA-abduced"} ! cochlear duct of membranous labyrinth
@@ -210698,8 +211694,8 @@ synonym: "portion of arterial blood" EXACT [FMA:83066]
 xref: FMA:83066
 is_a: UBERON:0000178 ! blood
 intersection_of: UBERON:0000178 ! blood
-intersection_of: part_of UBERON:0001637 ! artery
-relationship: part_of UBERON:0001637 ! artery
+intersection_of: located_in UBERON:0001637 ! artery
+relationship: located_in UBERON:0001637 ! artery
 
 [Term]
 id: UBERON:0013756
@@ -210711,8 +211707,8 @@ synonym: "venous blood" EXACT [FMA:83067]
 xref: FMA:83067
 is_a: UBERON:0000178 ! blood
 intersection_of: UBERON:0000178 ! blood
-intersection_of: part_of UBERON:0001638 ! vein
-relationship: part_of UBERON:0001638 ! vein
+intersection_of: located_in UBERON:0001638 ! vein
+relationship: located_in UBERON:0001638 ! vein
 
 [Term]
 id: UBERON:0013757
@@ -210725,8 +211721,8 @@ xref: FMA:263901
 xref: NCIT:C32212
 is_a: UBERON:0000178 ! blood
 intersection_of: UBERON:0000178 ! blood
-intersection_of: part_of UBERON:0001982 ! capillary
-relationship: part_of UBERON:0001982 ! capillary
+intersection_of: located_in UBERON:0001982 ! capillary
+relationship: located_in UBERON:0001982 ! capillary
 
 [Term]
 id: UBERON:0013758
@@ -210821,6 +211817,7 @@ xref: TAO:0005411
 xref: ZFA:0005411
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0010000 ! multicellular anatomical structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001856 ! semicircular duct
 
 [Term]
@@ -213878,6 +214875,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/279799003
 xref: UMLS:C0458781 {source="BIRNLEX:2522"}
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005913 ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0006723 ! cochlear modiolus
 
 [Term]
@@ -213890,6 +214888,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/279778001
 xref: UMLS:C0458766 {source="BIRNLEX:2556"}
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005913 ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0006106 ! cochlear canal
 
 [Term]
@@ -213902,6 +214901,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/279772000
 xref: UMLS:C0458761 {source="BIRNLEX:2558"}
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005913 ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0006106 ! cochlear canal
 
 [Term]
@@ -213914,6 +214914,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/279780007
 xref: UMLS:C0458768 {source="BIRNLEX:2559"}
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005913 ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0006106 ! cochlear canal
 
 [Term]
@@ -214621,9 +215622,9 @@ name: frontonasal process epithelium
 def: "An epithelium that is part of a frontonasal prominence." [OBOL:automatic]
 xref: EHDAA2:0004108
 xref: EMAPA:32918
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
 is_a: UBERON:0005291 ! embryonic tissue
+is_a: UBERON:0010371 ! ecto-epithelium
 intersection_of: UBERON:0000483 ! epithelium
 intersection_of: part_of UBERON:0004066 ! frontonasal prominence
 relationship: develops_from UBERON:0000076 {source="EHDAA2"} ! external ectoderm
@@ -214731,9 +215732,8 @@ relationship: part_of UBERON:0014710 ! carapacial ridge
 id: UBERON:0014712
 name: carapacial ridge ectoderm
 def: "An epithelium that is part of a carapacial ridge." [OBOL:automatic]
-is_a: CARO:0000000 ! anatomical entity
-is_a: UBERON:0000483 ! epithelium
 is_a: UBERON:0005291 ! embryonic tissue
+is_a: UBERON:0010371 ! ecto-epithelium
 intersection_of: UBERON:0000483 ! epithelium
 intersection_of: part_of UBERON:0014710 ! carapacial ridge
 relationship: develops_from UBERON:0000076 {source="cjm"} ! external ectoderm
@@ -217965,7 +218965,6 @@ xref: Lamina:terminalis
 xref: VHOG:0001547
 is_a: UBERON:0014532 {source="FMA"} ! white matter lamina of cerebral hemisphere
 relationship: develops_from UBERON:0005078 ! lamina terminalis of neural tube
-relationship: develops_from UBERON:0006222 ! future diencephalon
 relationship: immediate_transformation_of UBERON:0005078 ! lamina terminalis of neural tube
 relationship: part_of UBERON:0002437 {source="FMA"} ! cerebral hemisphere white matter
 
@@ -218642,6 +219641,7 @@ xref: FMA:55627
 xref: http://www.snomedbrowser.com/Codes/Details/28638008
 xref: NCIT:C32346
 is_a: UBERON:0001560 ! neck of organ
+is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0001560 ! neck of organ
 intersection_of: part_of UBERON:0001091 ! calcareous tooth
@@ -222091,6 +223091,7 @@ synonym: "otolith membrane" NARROW []
 xref: FMA:75570
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005764 {source="FMA"} ! acellular membrane
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: bounding_layer_of UBERON:0002518 {source="Wikipedia"} ! otolith organ
 relationship: part_of UBERON:0001862 {source="MA-abduced"} ! vestibular labyrinth
 relationship: part_of UBERON:0002518 ! otolith organ
@@ -222101,6 +223102,7 @@ name: gelatinous layer of statoconial membrane
 xref: FMA:75588
 is_a: UBERON:0000476 {source="FMA"} ! acellular anatomical structure
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0016567 {source="FMA"} ! statoconial membrane
 
 [Term]
@@ -222109,6 +223111,7 @@ name: subcupular meshwork of statoconial membrane
 def: "An acellular membrane in the inner ear that is part of the statoconial membrane and consists of long branching filaments cross-bridged to one another. The filaments are continuous with those of the otolithic membrane on one side and with the surface of the epithelium on the other." [ISBN:1565939948]
 is_a: UBERON:0000476 ! acellular anatomical structure
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0000476 ! acellular anatomical structure
 intersection_of: adjacent_to UBERON:0000483 ! epithelium
 intersection_of: adjacent_to UBERON:0002519 ! otolithic part of statoconial membrane
@@ -222339,8 +223342,8 @@ relationship: part_of UBERON:0016618 ! baleen feeding system
 id: UBERON:0016621
 name: lunge feeding organ
 def: "A fibrous capsule located between the jaws of rorqual whales that contains a gelatinous substance and papillae bearing mechanorecaptors." [http://www.ncbi.nlm.nih.gov/pubmed/22622577]
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0000020 ! sense organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0013765 ! digestive system element
 relationship: has_part UBERON:0016630 ! neurovascular bundle
 relationship: only_in_taxon NCBITaxon:9765 ! Balaenopteridae
@@ -222350,7 +223353,7 @@ relationship: part_of UBERON:0016618 ! baleen feeding system
 [Term]
 id: UBERON:0016622
 name: lunge feeding organ papilla
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:2001995 ! papilla
 intersection_of: UBERON:2001995 ! papilla
 intersection_of: part_of UBERON:0016621 ! lunge feeding organ
@@ -223204,6 +224207,7 @@ def: "A linear flat evelation on a tooth." [http://en.wikipedia.org/wiki/Dental_
 synonym: "crista of tooth" EXACT []
 synonym: "tooth ridge" EXACT []
 xref: http://www.snomedbrowser.com/Codes/Details/245699009
+is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:4100000 ! skeletal element projection
 relationship: part_of UBERON:0001091 ! calcareous tooth
@@ -224589,8 +225593,8 @@ xref: BAMS:APS
 xref: BIRNLEX:1096
 xref: DHBA:10642
 xref: FMA:61891
-xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=282
 xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=282 {source="BIRNLEX:1096"}
+xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=282
 xref: http://en.wikipedia.org/wiki/Anterior_perforated_substance
 xref: http://linkedlifedata.com/resource/umls/id/C0162436
 xref: http://www.snomedbrowser.com/Codes/Details/369108006
@@ -224728,8 +225732,8 @@ synonym: "Shrapnell's membrane" EXACT [FMA:56721]
 xref: FMA:56721
 xref: http://en.wikipedia.org/wiki/Pars_flaccida_of_tympanic_membrane
 xref: http://www.snomedbrowser.com/Codes/Details/279594005
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0000064 ! organ part
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0002364 {source="FMA"} ! tympanic membrane
 
 [Term]
@@ -224739,8 +225743,8 @@ synonym: "pars tensa (membrana tympanica)" EXACT [FMA:56722]
 synonym: "pars tensa membranae tympanicae" EXACT LATIN [FMA:56722, FMA:TA]
 xref: FMA:56722
 xref: http://www.snomedbrowser.com/Codes/Details/362555006
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0000064 ! organ part
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0002364 {source="FMA"} ! tympanic membrane
 
 [Term]
@@ -224914,6 +225918,7 @@ xref: NCIT:C32834
 is_a: UBERON:0001637 ! artery
 is_a: UBERON:0003496 ! head blood vessel
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: branching_part_of UBERON:0001633 {gci_relation="part_of", gci_filler="NCBITaxon:9606", cases="15%", source="WP"} ! basilar artery
 relationship: branching_part_of UBERON:0009689 {gci_relation="part_of", gci_filler="NCBITaxon:9606", cases="85-100%", source="WP"} ! anterior inferior cerebellar artery
 relationship: connected_to UBERON:0009689 {subset="human_reference_atlas"} ! anterior inferior cerebellar artery
@@ -225849,6 +226854,7 @@ def: "Area on the otic capsule for the articulation of the hyoid." [PHENOSCAPE:a
 xref: UBERONTEMP:e1c1764a-61b5-4dce-8a59-7ca5a9de0a0b
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0004905 ! articulation
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0004637 ! otic capsule
 
 [Term]
@@ -225998,6 +227004,7 @@ def: "An embryonic fissure between the otic capsule and the arches which develop
 xref: UBERONTEMP:41980771-8a82-40d2-877e-3156cc80857b
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0006846 ! surface groove
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0004637 ! otic capsule
 
 [Term]
@@ -226049,6 +227056,7 @@ relationship: part_of UBERON:0018345 ! stylar shelf
 id: UBERON:0018345
 name: stylar shelf
 def: "The stylar shelf is an an expansion of the cingulum; it often bears small cusps (each with its own name...)." [http://animaldiversity.ummz.umich.edu/collections/mammal_anatomy/cheek_teeth_structure, PHENOSCAPE:curators]
+is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:4100000 ! skeletal element projection
 relationship: part_of UBERON:0013164 ! molariform tooth
@@ -226297,6 +227305,7 @@ def: "A unit of the tectoral membrane that is shaped like string of flat, pearls
 xref: UBERONTEMP:caa10252-5f7e-4a55-a72c-cf7986a89363
 is_a: UBERON:0000063 ! organ subunit
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: only_in_taxon NCBITaxon:8504 {source="ISBN:9780387714691"} ! Lepidosauria
 relationship: part_of UBERON:0002233 ! tectorial membrane of cochlea
 relationship: present_in_taxon NCBITaxon:35033 {source="ISBN:9780387714691"}
@@ -227737,6 +228746,7 @@ def: "An opening of the otic duct within the inner ear. The recessus basilaris c
 synonym: "basilar papillar recess" EXACT []
 is_a: UBERON:0000064 ! organ part
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001846 ! internal ear
 
 [Term]
@@ -233812,6 +234822,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/279843007
 xref: MA:0003003
 is_a: UBERON:0000481 ! multi-tissue structure
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001855 {source="MA"} ! cochlear duct of membranous labyrinth
 
 [Term]
@@ -237629,6 +238640,7 @@ id: UBERON:0035045
 name: parotid gland intralobular duct
 def: "Any of the tubular canals of the parotid gland located within the parenchymal (secretory) tissue i.e. within lobules; both intercalated and striated (secretory) ducts are intralobular ducts." [MP:0013746]
 is_a: UBERON:0001837 ! duct of salivary gland
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0014719 ! intralobular duct
 intersection_of: UBERON:0014719 ! intralobular duct
 intersection_of: part_of UBERON:0001831 ! parotid gland
@@ -237658,6 +238670,7 @@ relationship: part_of UBERON:0001831 ! parotid gland
 id: UBERON:0035048
 name: parotid gland excretory duct
 def: "Any of the interlobular excretory ducts of the parotid gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts; ultimately, the excretory ducts of the parotid gland coalesce and form a single main excretory duct (Stensen's duct) that opens into the oral cavity; excretory ducts do not change the secretory product." [MP:0013750]
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0035049 ! excretory duct of salivary gland
 intersection_of: UBERON:0035050 ! excretory duct
 intersection_of: part_of UBERON:0001831 ! parotid gland
@@ -238321,8 +239334,7 @@ synonym: "ossicle element" BROAD [EMAPA:17824, http://en.wikipedia.org/wiki/Audi
 synonym: "ossicle element of ear" RELATED []
 synonym: "ossicle element of inner ear" RELATED []
 synonym: "ossicular chain element" RELATED PLURAL []
-is_a: UBERON:0004121 ! ectoderm-derived structure
-is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
+is_a: UBERON:0010313 ! neural crest-derived structure
 is_a: UBERON:0010363 ! endochondral element
 relationship: contributes_to_morphology_of UBERON:0001756 ! middle ear
 relationship: develops_from UBERON:0003099 {source="http://www.ncbi.nlm.nih.gov/pubmed/11237469", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! cranial neural crest
@@ -240706,11 +241718,6 @@ synonym: "ophthalmic part of trigeminal ganglion" RELATED []
 synonym: "profundal ganglion" NARROW SENSU []
 is_a: UBERON:0001714 ! cranial ganglion
 is_a: UBERON:0010313 ! neural crest-derived structure
-relationship: develops_from UBERON:0000033 ! head
-relationship: develops_from UBERON:0000153 ! anterior region of body
-relationship: develops_from UBERON:0007811 ! craniocervical region
-relationship: develops_from UBERON:0013701 ! main body axis
-relationship: develops_from UBERON:0013702 ! body proper
 relationship: develops_from UBERON:0035597 ! profundal placode
 relationship: immediate_transformation_of UBERON:0035597 ! profundal placode
 relationship: part_of UBERON:0001675 ! trigeminal ganglion
@@ -240724,11 +241731,6 @@ synonym: "ophthalmic ganglion" NARROW SENSU []
 synonym: "profundal ganglion" NARROW SENSU []
 is_a: UBERON:0001714 ! cranial ganglion
 is_a: UBERON:0010313 ! neural crest-derived structure
-relationship: develops_from UBERON:0000033 ! head
-relationship: develops_from UBERON:0000153 ! anterior region of body
-relationship: develops_from UBERON:0007811 ! craniocervical region
-relationship: develops_from UBERON:0013701 ! main body axis
-relationship: develops_from UBERON:0013702 ! body proper
 relationship: develops_from UBERON:0035598 ! maxillomandibular placode
 relationship: immediate_transformation_of UBERON:0035598 ! maxillomandibular placode
 relationship: part_of UBERON:0001675 ! trigeminal ganglion
@@ -240771,6 +241773,7 @@ synonym: "cartilago meatus acustici" EXACT [FMA:TA]
 synonym: "external acoustic meatus cartilage" EXACT [FMA:61298]
 xref: FMA:61298
 is_a: UBERON:0004119 ! endoderm-derived structure
+is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0034944 ! zone of organ
 intersection_of: UBERON:0034944 ! zone of organ
 intersection_of: part_of UBERON:0001352 ! external acoustic meatus
@@ -241553,6 +242556,7 @@ def: "The dark, nonstriated, V-shaped band (ridge) found on the underside of the
 synonym: "Hensen's stripe" EXACT [MGI:anna]
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005764 {source="cjm"} ! acellular membrane
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: adjacent_to UBERON:0002233 ! tectorial membrane of cochlea
 relationship: part_of UBERON:0001855 {source="cjm"} ! cochlear duct of membranous labyrinth
 
@@ -242610,6 +243614,7 @@ name: Kimura membrane
 def: "The thickening of the lower surface of the tectorial membrane into which the hair bundles of the outer hair cells are embedded." [http://www.ncbi.nlm.nih.gov/pubmed/18797289, https://github.com/obophenotype/mammalian-phenotype-ontology/issues/2141, https://github.com/obophenotype/uberon/issues/1200, MGI:smith]
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005764 {source="cjm"} ! acellular membrane
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0002233 ! tectorial membrane of cochlea
 
 [Term]
@@ -243622,8 +244627,8 @@ synonym: "sulcus auriculae anterior" RELATED [http://en.wikipedia.org/wiki/Incis
 xref: FMA:61175
 xref: http://en.wikipedia.org/wiki/Incisura_anterior_auris
 xref: http://www.snomedbrowser.com/Codes/Details/362542005
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0006846 ! surface groove
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0006846 ! surface groove
 intersection_of: adjacent_to UBERON:0010887 ! tragus
 intersection_of: adjacent_to UBERON:0016467 ! antitragus
@@ -243843,6 +244848,7 @@ synonym: "zone of organ of corti" RELATED []
 xref: http://www.snomedbrowser.com/Codes/Details/361065006
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005764 ! acellular membrane
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0005764 ! acellular membrane
 intersection_of: part_of UBERON:0002226 ! basilar membrane of cochlea
 relationship: part_of UBERON:0002226 ! basilar membrane of cochlea
@@ -244380,6 +245386,7 @@ id: UBERON:0036655
 name: wall of cerebral aqueduct
 xref: FMA:242774
 is_a: UBERON:0005358 {source="FMA"} ! ventricle of nervous system
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0036661 ! wall of ventricular system of brain
 intersection_of: UBERON:0000060 ! anatomical wall
 intersection_of: part_of UBERON:0002289 ! midbrain cerebral aqueduct
@@ -244496,6 +245503,7 @@ synonym: "membranous labyrinth wall" EXACT [FMA:79837]
 xref: FMA:79837
 is_a: UBERON:0000060 {source="FMA"} ! anatomical wall
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 intersection_of: UBERON:0000060 ! anatomical wall
 intersection_of: part_of UBERON:0001849 ! membranous labyrinth
 relationship: part_of UBERON:0001849 {source="FMA"} ! membranous labyrinth
@@ -245967,8 +246975,8 @@ name: rima vulvae
 def: "The fissure between the labia majora" [https://www.thefreedictionary.com/pudendal+cleft]
 synonym: "pudendal cleft" EXACT DEPRECATED [https://doi.org/10.1002/ca.23705]
 synonym: "pudendal cleft" EXACT [FMA:19995]
-synonym: "rima pudendi" EXACT LATIN [A09.2.01.006]
 synonym: "rima pudendi" EXACT DEPRECATED [https://doi.org/10.1002/ca.23705]
+synonym: "rima pudendi" EXACT LATIN [A09.2.01.006]
 synonym: "urogenital cleft" BROAD [https://www.thefreedictionary.com/pudendal+cleft]
 synonym: "vulvar slit" EXACT [https://www.thefreedictionary.com/pudendal+cleft]
 xref: FMA:19995
@@ -246222,6 +247230,7 @@ name: chin ventral margin
 def: "Subdivision of the head consisting of the area along the lower edge of the chin." [https://github.com/obophenotype/uberon/issues/34, UBERON:EJS]
 subset: phenotype_rcn
 is_a: UBERON:0001444 ! subdivision of head
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 property_value: dc-contributor https://github.com/cmungall
 property_value: dc-contributor https://github.com/seger
 relationship: part_of UBERON:0008199 ! chin
@@ -247018,6 +248027,7 @@ def: "Brightly refractile stone-like organ within the otic vesicle and positione
 synonym: "immature otoliths" EXACT PLURAL [TAO:0000139]
 is_a: UBERON:0003103 ! compound organ
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0003051 ! ear vesicle
 
 [Term]
@@ -247355,6 +248365,7 @@ synonym: "pleurethmoïde" EXACT [PSPUB:0000134]
 synonym: "éthmoïde latéral" EXACT [PSPUB:0000164]
 xref: ZFA:0000226
 is_a: UBERON:0002513 ! endochondral bone
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011164 ! neurocranium bone
 is_a: UBERON:4300111 ! lateral ethmoid element
 relationship: composed_primarily_of UBERON:0002481 ! bone tissue
@@ -247875,6 +248886,7 @@ name: basioccipital posterodorsal region
 def: "Endochondral bone which is the posterodorsal region of the basioccipital bone." [TAO:wd]
 xref: ZFA:0001598
 is_a: UBERON:0002513 ! endochondral bone
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011164 ! neurocranium bone
 relationship: part_of UBERON:0001692 ! basioccipital bone
 relationship: part_of UBERON:2001620 ! lagenar capsule
@@ -247918,6 +248930,7 @@ name: exoccipital posteroventral region
 def: "Endochondral bone which is the posterodorsal region of the exoccipital bone." [TAO:wd]
 xref: ZFA:0001597
 is_a: UBERON:0002513 ! endochondral bone
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011164 ! neurocranium bone
 relationship: part_of UBERON:0001693 ! exoccipital bone
 relationship: part_of UBERON:2001620 ! lagenar capsule
@@ -248226,6 +249239,7 @@ synonym: "alisphenoid" EXACT [TAO:0000419]
 synonym: "pterosphenoids" EXACT PLURAL [TAO:0000419]
 xref: ZFA:0000419
 is_a: UBERON:0002513 ! endochondral bone
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011164 ! neurocranium bone
 relationship: develops_from UBERON:2001515 ! taenia marginalis posterior
 relationship: part_of UBERON:0002241 ! chondrocranium
@@ -249000,6 +250014,7 @@ synonym: "autosphenotic" EXACT [TAO:0000587]
 synonym: "sphenotics" EXACT PLURAL [TAO:0000587]
 xref: ZFA:0000587
 is_a: UBERON:0002513 ! endochondral bone
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011164 ! neurocranium bone
 relationship: develops_from UBERON:0006605 ! tectum synoticum
 relationship: develops_from UBERON:2001515 ! taenia marginalis posterior
@@ -249612,7 +250627,6 @@ synonym: "pharyngeal teeth" EXACT [TAO:0000694]
 xref: ZFA:0000694
 is_a: CARO:0000003
 is_a: UBERON:0001091 ! calcareous tooth
-is_a: UBERON:0004121 ! ectoderm-derived structure
 intersection_of: UBERON:0001091 ! calcareous tooth
 intersection_of: attaches_to UBERON:2001239 ! ceratobranchial 5 bone
 relationship: attaches_to UBERON:2001239 ! ceratobranchial 5 bone
@@ -253389,6 +254403,7 @@ name: preethmoid bone
 def: "Small rounded to egg-shaped cartilage bone that sits in an anterolateral depression on the prevomer. Articulates with the autopalatine in all cypriniforms." [ZFIN:curator]
 xref: ZFA:0001404
 is_a: UBERON:0002513 ! endochondral bone
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011164 ! neurocranium bone
 relationship: develops_from UBERON:0011242 ! ethmoid cartilage
 relationship: part_of UBERON:0002241 ! chondrocranium
@@ -253441,6 +254456,7 @@ synonym: "epioccipitals" EXACT PLURAL [TAO:0001412]
 xref: ZFA:0001412
 is_a: UBERON:0002513 ! endochondral bone
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011164 ! neurocranium bone
 relationship: develops_from UBERON:0005410 ! cartilaginous otic capsule
 relationship: part_of UBERON:0002241 ! chondrocranium
@@ -254363,6 +255379,7 @@ name: lateral ethmoid palatine process
 def: "Lateral bony projection proximal to lateral ethmoid-palatine joint, and located anterior to orbital region and posterior to olfactory region." [TAO:wd]
 synonym: "antorbital process" RELATED [TAO:0001604]
 is_a: UBERON:0004530 ! bony projection
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:2000226 ! lateral ethmoid bone
 
 [Term]
@@ -254470,7 +255487,7 @@ id: UBERON:2001615
 name: sphenotic spine
 def: "Process of the sphenotic. The process may project antero-laterally or laterally or ventro-laterally and it has different development in different fish groups. The sphenotic spine is paired." [TAO:GA_TG]
 synonym: "sphenotic process" EXACT [TAO:0001615]
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:4100000 ! skeletal element projection
 relationship: part_of UBERON:2000587 ! sphenotic
 
@@ -254480,7 +255497,7 @@ name: lateral ethmoid wing
 def: "Superficial and lateral bony projection anterior to orbital region. Sometimes with superficial ornamentation where in direct contact with skin." [TAO:wd]
 comment: Synonym of lateral ethmoid wing: lateral ethmoid ventral wing (characiforms).
 synonym: "lateral ethmoid ventral wing" EXACT [TAO:0001616]
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:4100000 ! skeletal element projection
 relationship: part_of UBERON:2000226 ! lateral ethmoid bone
 
@@ -254843,7 +255860,7 @@ def: "Bony projection that extends from the mesethmoid anteriorly. Mesethmoid co
 synonym: "cornu" EXACT [TAO:0001675]
 synonym: "cornua" EXACT PLURAL [TAO:0001675]
 synonym: "cornuae" EXACT PLURAL [TAO:0001675]
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:4100000 ! skeletal element projection
 relationship: part_of UBERON:0011238 ! mesethmoid bone
 
@@ -254909,7 +255926,7 @@ relationship: connects UBERON:0011238 ! mesethmoid bone
 id: UBERON:2001681
 name: cornu mesial process
 def: "Bony projection that is mesially-directed and off the anteromedial corner of each mesethmoid cornu." [TAO:pem]
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:4100000 ! skeletal element projection
 relationship: part_of UBERON:2001675 ! mesethmoid cornu
 
@@ -255326,7 +256343,7 @@ id: UBERON:2001733
 name: mesethmoid ventral diverging lamella
 def: "Bony projection that is the posterolaterally oriented projection on the ventral region of the mesethmoid. Mesethmoid ventral diverging lamellae are paired and posteriorly contact the lateral ethmoid bones." [TAO:wd]
 comment: Reference: Weitzman 1962.
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:4100000 ! skeletal element projection
 relationship: part_of UBERON:0011238 ! mesethmoid bone
 
@@ -255421,7 +256438,7 @@ def: "Bony projection located on the anteroventral region of the mesethmoid whic
 comment: Synonyms: mesethmoid lateral wing (Zanata and Vari 2005) lateral ethmoid wing (Weitzman 1962) premaxillary articular process (Fink and Fink 1996).
 synonym: "mesethmoid lateral wing" EXACT [TAO:0001747]
 synonym: "premaxillary articular process" EXACT [TAO:0001747]
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:4100000 ! skeletal element projection
 relationship: part_of UBERON:0011238 ! mesethmoid bone
 
@@ -255699,7 +256716,7 @@ def: "Process that is part of the supraoccipital. It is a posteriorly directed a
 comment: The supraoccipital crest may be small and restricted to the dorsal part of the supraoccipital, or may be large and long and extending ventrally to the dorsal margin of the foramen magnum. The supraoccipital crest may be a large process extending above the skull roof in some teleostean subgroups.
 synonym: "supraoccipital process" EXACT [TAO:0001783]
 synonym: "supraoccipital spine" EXACT [TAO:0001783]
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:4100000 ! skeletal element projection
 relationship: part_of UBERON:0004747 ! supraoccipital bone
 
@@ -256826,6 +257843,7 @@ name: epioccipital posterior process
 def: "Process of the epioccipital that extends posteriorly, is laminar in form and is usually attached to Weberian apparatus." [TAO:wd]
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0004530 ! bony projection
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:2001412 ! epiotic
 
 [Term]
@@ -257621,6 +258639,7 @@ id: UBERON:2002023
 name: second preethmoid bone
 def: "Endochondral bone found between the preethmoid and maxilla." [TAO:wd]
 is_a: UBERON:0002513 ! endochondral bone
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0011164 ! neurocranium bone
 is_a: UBERON:4300286 ! second preethmoid element
 relationship: develops_from UBERON:4300285 ! second preethmoid cartilage
@@ -258069,7 +259088,7 @@ is_a: UBERON:0002548 ! larva
 id: UBERON:2002080
 name: spina occipitalis
 def: "Process that is a ventral projection from the supraoccipital that extends between the exoccipitals to the dorsal margin of the foramen magnum." [TAO:wd]
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:4100000 ! skeletal element projection
 relationship: part_of UBERON:0004747 ! supraoccipital bone
 
@@ -258698,6 +259717,7 @@ synonym: "dorsal bar" RELATED [TAO:0002193]
 xref: ZFA:0001672
 is_a: UBERON:0000479 ! tissue
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001841 ! anterior semicircular canal
 relationship: part_of UBERON:0001842 ! posterior semicircular canal
 
@@ -258811,6 +259831,7 @@ name: otic vesicle protrusion
 xref: ZFA:0001715
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005291 ! embryonic tissue
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0003051 ! ear vesicle
 
 [Term]
@@ -258866,6 +259887,7 @@ name: pillar of the semicircular canal
 xref: ZFA:0001717
 is_a: UBERON:0000479 ! tissue
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001840 ! semicircular canal
 
 [Term]
@@ -261115,6 +262137,7 @@ name: common crus
 xref: ZFA:0005411
 is_a: UBERON:0000058 ! duct
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:2005409 ! pars superior ear
 
 [Term]
@@ -261132,6 +262155,7 @@ def: "Foramen in the inner ear." [ZFIN:curator]
 xref: ZFA:0005415
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005744 ! bone foramen
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001846 ! internal ear
 
 [Term]
@@ -261493,7 +262517,6 @@ synonym: "ventral bar" EXACT [TAO:0007055]
 synonym: "ventral pillar" EXACT [TAO:0007055]
 synonym: "ventral piller of the semicircular canal" EXACT [TAO:0007055]
 xref: ZFA:0007055
-is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:2002223 ! pillar of the semicircular canal
 relationship: develops_from UBERON:2001716 ! caudal principal ray 4
 relationship: part_of UBERON:0001843 ! lateral semicircular canal
@@ -262688,6 +263711,7 @@ id: UBERON:3000141
 name: endolymphatic system
 is_a: UBERON:0000467 ! anatomical system
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001846 ! internal ear
 
 [Term]
@@ -262773,8 +263797,7 @@ synonym: "otostapes" RELATED [UBERON:3000178]
 synonym: "pars otica columellae" RELATED [UBERON:3000178]
 synonym: "pseudooperculum" RELATED [UBERON:3000178]
 is_a: UBERON:0000064 ! organ part
-is_a: UBERON:0004121 ! ectoderm-derived structure
-is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
+is_a: UBERON:0010313 ! neural crest-derived structure
 relationship: part_of UBERON:3000408 ! pars media plectri
 
 [Term]
@@ -263249,6 +264272,7 @@ id: UBERON:3000393
 name: pars amphibiorum
 is_a: UBERON:0000479 ! tissue
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001854 ! saccule of membranous labyrinth
 
 [Term]
@@ -263264,6 +264288,7 @@ id: UBERON:3000395
 name: pars basilaris
 is_a: UBERON:0000479 ! tissue
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001854 ! saccule of membranous labyrinth
 
 [Term]
@@ -263292,8 +264317,7 @@ synonym: "hyostapes" RELATED [UBERON:3000399]
 synonym: "medio-stapedial" RELATED [UBERON:3000399]
 synonym: "pars quadrata columellae" RELATED [UBERON:3000399]
 is_a: UBERON:0000064 ! organ part
-is_a: UBERON:0004121 ! ectoderm-derived structure
-is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
+is_a: UBERON:0010313 ! neural crest-derived structure
 relationship: part_of UBERON:3000443 ! plectral apparatus
 
 [Term]
@@ -263315,6 +264339,7 @@ id: UBERON:3000405
 name: pars inferior of labyrinth
 is_a: UBERON:0000064 ! organ part
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001846 ! internal ear
 
 [Term]
@@ -263324,16 +264349,14 @@ def: "Plate-like structure that lies in the fenestra ovalis. It arises within th
 synonym: "operculum auris" RELATED [UBERON:3000406]
 synonym: "operculum fenestrae ovalis" RELATED [UBERON:3000406]
 is_a: UBERON:0000064 ! organ part
-is_a: UBERON:0004121 ! ectoderm-derived structure
-is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
+is_a: UBERON:0010313 ! neural crest-derived structure
 relationship: part_of UBERON:3000443 ! plectral apparatus
 
 [Term]
 id: UBERON:3000408
 name: pars media plectri
 is_a: UBERON:0000064 ! organ part
-is_a: UBERON:0004121 ! ectoderm-derived structure
-is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
+is_a: UBERON:0010313 ! neural crest-derived structure
 relationship: part_of UBERON:3000443 ! plectral apparatus
 
 [Term]
@@ -263357,6 +264380,7 @@ name: perilymphatic system
 def: "Consists of enlarged cistern against which the operculum and footplate of the columella rest in the oval window. Together with the endolymphatic systems comprises the membranous labryinth of the inner ear. Duellman and Trueb 1994." [PHENOSCAPE]
 is_a: UBERON:0001032 ! sensory system
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001846 ! internal ear
 
 [Term]
@@ -263526,8 +264550,7 @@ synonym: "processus ascendens columellae" RELATED [UBERON:3000486]
 synonym: "processus dorsalis columellae" RELATED [UBERON:3000486]
 synonym: "processus superior columellae" RELATED [UBERON:3000486]
 synonym: "suprastapediale" RELATED [UBERON:3000486]
-is_a: UBERON:0004121 ! ectoderm-derived structure
-is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
+is_a: UBERON:0010313 ! neural crest-derived structure
 is_a: UBERON:4100000 ! skeletal element projection
 relationship: part_of UBERON:3000399 ! pars externa plectri
 
@@ -263658,6 +264681,7 @@ id: UBERON:3000538
 name: recessus fenestrae ovalis
 is_a: UBERON:0000064 ! organ part
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:3000428 ! perilymphatic system
 
 [Term]
@@ -263700,6 +264724,7 @@ name: septum semicircularium anterior
 def: "The anterior connective tissue partition between walls of otic capsule around which the membranous semicircular canals pass." [PHENOSCAPE]
 is_a: UBERON:0003037 ! septum
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001846 ! internal ear
 
 [Term]
@@ -263708,6 +264733,7 @@ name: septum semicircularium laterale
 def: "The lateral connective tissue partition between walls of otic capsule around which the membranous semicircular canals pass." [PHENOSCAPE]
 is_a: UBERON:0003037 ! septum
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001846 ! internal ear
 
 [Term]
@@ -263716,6 +264742,7 @@ name: septum semircularium posterior
 def: "The posterior connective tissue partition between walls of otic capsule around which the membranous semicircular canals pass." [PHENOSCAPE]
 is_a: UBERON:0003037 ! septum
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001846 ! internal ear
 
 [Term]
@@ -263749,6 +264776,7 @@ id: UBERON:3000570
 name: spatium sacculare
 is_a: UBERON:0000064 ! organ part
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:3000428 ! perilymphatic system
 
 [Term]
@@ -263781,8 +264809,7 @@ synonym: "stapes" RELATED [UBERON:3000580]
 synonym: "stelidium" RELATED [UBERON:3000580]
 synonym: "stilus columellare" RELATED [UBERON:3000580]
 is_a: UBERON:0000064 ! organ part
-is_a: UBERON:0004121 ! ectoderm-derived structure
-is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
+is_a: UBERON:0010313 ! neural crest-derived structure
 relationship: part_of UBERON:3000408 ! pars media plectri
 
 [Term]
@@ -263974,8 +265001,7 @@ relationship: part_of UBERON:3000492 ! processus infrafenestralis
 id: UBERON:3000648
 name: crista praeopercularis
 def: "Synchondrotic or synostotic connection between the footplate of the pars media plectri and the ventral margin of the fenestra ovalis." [AAO:LAP]
-is_a: UBERON:0004121 ! ectoderm-derived structure
-is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
+is_a: UBERON:0010313 ! neural crest-derived structure
 is_a: UBERON:4100000 ! skeletal element projection
 relationship: part_of UBERON:3000408 ! pars media plectri
 
@@ -266197,8 +267223,8 @@ relationship: part_of UBERON:3000993 ! otic and occipital
 id: UBERON:3010144
 name: odontoids
 def: "Toothlike processes found on the mandible of some anurans; can be formed by dentary or dentary + mentomeckelian bones; odontoids lack enamel and dentine present in true teeth." [AAO:EJS]
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0000064 ! organ part
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001710 ! lower jaw region
 
 [Term]
@@ -268033,6 +269059,7 @@ name: ramus anterior of CN VIII
 def: "Formed by fibers from the anterior semicircular canal and sacculus." [AAO:EJS]
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0004529 ! anatomical projection
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001648 ! vestibulocochlear nerve
 
 [Term]
@@ -268041,6 +269068,7 @@ name: ramus posterior of CN VIII
 def: "Composed of two rami: a short ventral ramus innervating the cochlea (lagena and papille basilar), and a long dorsal ramus innervating the posterior semicircular canal." [AAO:EJS]
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0004529 ! anatomical projection
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 relationship: part_of UBERON:0001648 ! vestibulocochlear nerve
 
 [Term]
@@ -271906,6 +272934,7 @@ name: tectorial restraint system
 def: "Tectorial restraint system is a type of ciliary restraint system for hair cells in the inner ear.  In tectorial restraint systems, the tectorial membrane restrains the cilia of the hair cells by attaching either directly to ciliary tufts or indirectly through various kinds of fibrous structure (simple fibers, fibrous strands, finger-like processes, tectorial plates) [Phylogenetic Relationships of the Lizard Families: Essays Commemorating Charles L. Camp. 1988. Eds. R Estes, GK Pregill. Stanford University Press]." [PHENOSCAPE]
 is_a: UBERON:0000467 ! anatomical system
 is_a: UBERON:0004121 ! ectoderm-derived structure
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 property_value: dc-contributor https://orcid.org/0000-0003-3162-7490
 relationship: part_of UBERON:0001846 ! internal ear
 
@@ -272712,7 +273741,7 @@ id: UBERON:4300249
 name: lateral occipital foramen
 def: "Foramen that has the exoccipital as the anterior and dorsal rim. The occipital forms the anterior rim during early development. [database_cross_reference: GOC:cvs][database_cross_reference: https://orcid.org/0000-0002-2244-7917][database_cross_reference: ZFIN:ZDB-PUB-961014-192]." [ZFIN:ZDB-PUB-961014-192]
 xref: ZFA:0005892
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 is_a: UBERON:0013685 ! foramen of skull
 relationship: part_of UBERON:0001693 ! exoccipital bone
 
@@ -272814,6 +273843,7 @@ def: "Extension of the exoccipital that extends over the posttemporal fossa." [h
 synonym: "epiotic bridge" EXACT []
 is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005913 ! zone of bone organ
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
 property_value: dc-contributor https://orcid.org/0000-0003-3162-7490
 relationship: part_of UBERON:2001412 ! epiotic
 
@@ -275468,7 +276498,7 @@ name: insect tergite
 def: "The dorsal plate (sclerite) of an adult abdominal segment." [FlyBase:FBrf0007734, FlyBase:FBrf0111704]
 synonym: "abdominal tergite" EXACT []
 xref: FBbt:00004476
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:6004475 ! insect sclerite
 relationship: develops_from UBERON:6001792 ! insect anterior dorsal histoblast nest abdominal
 relationship: develops_from UBERON:6001809 ! insect posterior dorsal histoblast nest abdominal
@@ -276063,7 +277093,7 @@ relationship: part_of UBERON:0000924 ! ectoderm
 id: UBERON:6007046
 name: insect dorsal ectoderm derivative
 xref: FBbt:00007046
-is_a: CARO:0000000 ! anatomical entity
+is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0010000 ! multicellular anatomical structure
 relationship: develops_from UBERON:6000112 ! insect dorsal ectoderm
 
@@ -276273,8 +277303,8 @@ relationship: part_of UBERON:0000922 ! embryo
 id: UBERON:6017021
 name: insect abdominal histoblast anlage
 xref: FBbt:00017021
-is_a: CARO:0000000 ! anatomical entity
 is_a: UBERON:0002050 ! embryonic structure
+is_a: UBERON:0004121 ! ectoderm-derived structure
 is_a: UBERON:0005291 ! embryonic tissue
 is_a: UBERON:0007688 ! anlage
 relationship: develops_from UBERON:6005526 ! insect dorsal epidermis primordium
@@ -278385,6 +279415,16 @@ synonym: "RP3V" EXACT [http://www.ncbi.nlm.nih.gov/pubmed/17604108]
 is_a: UBERON:0035014 ! functional part of brain
 relationship: part_of UBERON:0006569 ! diencephalic nucleus
 
+[Term]
+id: UBERON:8470000
+name: placental blood
+def: "Blood located in the placenta." [http://orcid.org/0000-0001-6595-0902, https://www.ncbi.nlm.nih.gov/books/NBK53254/]
+is_a: UBERON:0000178 ! blood
+intersection_of: UBERON:0000178 ! blood
+intersection_of: located_in UBERON:0001987 ! placenta
+property_value: dc-contributor http://orcid.org/0000-0002-1773-2692
+relationship: located_in UBERON:0001987 ! placenta
+
 [Term]
 id: http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=10848
 name: SHH (human)
@@ -278566,6 +279606,7 @@ is_metadata_tag: true
 id: acts_upstream_of
 name: acts upstream of
 def: "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." []
+subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
 xref: RO:0002263
 holds_over_chain: enables causally_upstream_of
 is_a: acts_upstream_of_or_within ! acts upstream of or within
@@ -278574,24 +279615,32 @@ is_a: acts_upstream_of_or_within ! acts upstream of or within
 id: acts_upstream_of,_negative_effect
 name: acts upstream of, negative effect
 def: "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" []
+subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
 xref: RO:0004035
 holds_over_chain: enables causally_upstream_of,_negative_effect
 is_a: acts_upstream_of ! acts upstream of
 is_a: acts_upstream_of_or_within,_negative_effect ! acts upstream of or within, negative effect
+created_by: cjm
+creation_date: 2018-01-26T23:53:22Z
 
 [Typedef]
 id: acts_upstream_of,_positive_effect
 name: acts upstream of, positive effect
 def: "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" []
+subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
 xref: RO:0004034
 holds_over_chain: enables causally_upstream_of,_positive_effect
 is_a: acts_upstream_of ! acts upstream of
 is_a: acts_upstream_of_or_within,_positive_effect ! acts upstream of or within, positive effect
+created_by: cjm
+creation_date: 2018-01-26T23:53:14Z
 
 [Typedef]
 id: acts_upstream_of_or_within
 name: acts upstream of or within
 def: "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." []
+subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
+synonym: "affects" RELATED []
 xref: RO:0002264
 holds_over_chain: enables causally_upstream_of_or_within
 is_a: causal_agent_in_process ! causal agent in process
@@ -278599,21 +279648,28 @@ is_a: causal_agent_in_process ! causal agent in process
 [Typedef]
 id: acts_upstream_of_or_within,_negative_effect
 name: acts upstream of or within, negative effect
+subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
 xref: RO:0004033
 holds_over_chain: enables causally_upstream_of_or_within,_negative_effect
 is_a: acts_upstream_of_or_within ! acts upstream of or within
+created_by: cjm
+creation_date: 2018-01-26T23:49:51Z
 
 [Typedef]
 id: acts_upstream_of_or_within,_positive_effect
 name: acts upstream of or within, positive effect
+subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
 xref: RO:0004032
 holds_over_chain: enables causally_upstream_of_or_within,_positive_effect
 is_a: acts_upstream_of_or_within ! acts upstream of or within
+created_by: cjm
+creation_date: 2018-01-26T23:49:30Z
 
 [Typedef]
 id: adjacent_to
 name: adjacent to
 def: "x adjacent to y if and only if x and y share a boundary." []
+def: "x adjacent_to y iff: x and y share a boundary" []
 def: "x adjacent_to y iff: x and y share a boundary." []
 xref: RO:0002220
 domain: BFO:0000004 ! independent continuant
@@ -278639,10 +279695,12 @@ id: anterior_to
 name: anterior to
 name: anterior_to
 def: "x anterior to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail." [BSPO:cjm]
+def: "x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer" [http://orcid.org/0000-0002-6601-2165]
 def: "x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer." [http://orcid.org/0000-0002-6601-2165]
 xref: BSPO:0000096
 is_transitive: true
 inverse_of: posterior_to ! posterior to
+created_by: cjm
 creation_date: 2009-07-31T02:15:46Z
 
 [Typedef]
@@ -278695,6 +279753,7 @@ is_metadata_tag: true
 [Typedef]
 id: bearer_of
 name: has characteristic
+def: "a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence" []
 def: "Inverse of characteristic_of" []
 xref: RO:0000053
 range: BFO:0000020 ! specifically dependent continuant
@@ -278759,6 +279818,7 @@ range: BFO:0000015 ! process
 is_transitive: false
 is_a: capable_of_part_of ! capable of part of
 is_a: functionally_related_to ! functionally related to
+expand_expression_to: "RO_0000053 some (RO_0000054 only ?Y)" []
 
 [Typedef]
 id: capable_of_negatively_regulating
@@ -278776,6 +279836,7 @@ xref: RO:0002216
 holds_over_chain: capable_of part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
 is_a: causal_agent_in_process ! causal agent in process
 is_a: functionally_related_to ! functionally related to
+expand_expression_to: "RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y))" []
 
 [Typedef]
 id: capable_of_positively_regulating
@@ -278840,6 +279901,7 @@ inverse_of: causally_upstream_of ! causally upstream of
 id: causally_downstream_of_or_within
 name: causally downstream of or within
 def: "inverse of causally upstream of or within" []
+subset: RO:0002259
 xref: RO:0002427
 is_transitive: true
 is_a: causal_relation_between_processes ! causal relation between processes
@@ -278870,6 +279932,8 @@ xref: RO:0002410
 id: causally_upstream_of
 name: causally upstream of
 def: "p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain" []
+subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
+subset: http://purl.obolibrary.org/obo/valid_for_gocam
 xref: RO:0002411
 is_transitive: true
 is_a: causally_upstream_of_or_within ! causally upstream of or within
@@ -278878,6 +279942,7 @@ is_a: precedes ! precedes
 [Typedef]
 id: causally_upstream_of,_negative_effect
 name: causally upstream of, negative effect
+comment: holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y
 xref: RO:0002305
 is_a: causally_upstream_of ! causally upstream of
 is_a: causally_upstream_of_or_within,_negative_effect ! causally upstream of or within, negative effect
@@ -278885,6 +279950,9 @@ is_a: causally_upstream_of_or_within,_negative_effect ! causally upstream of or
 [Typedef]
 id: causally_upstream_of,_positive_effect
 name: causally upstream of, positive effect
+comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y
+subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
+subset: http://purl.obolibrary.org/obo/valid_for_gocam
 xref: RO:0002304
 is_a: causally_upstream_of ! causally upstream of
 is_a: causally_upstream_of_or_within,_positive_effect ! causally upstream of or within, positive effect
@@ -278893,6 +279961,7 @@ is_a: causally_upstream_of_or_within,_positive_effect ! causally upstream of or
 id: causally_upstream_of_or_within
 name: causally upstream of or within
 def: "p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q." []
+synonym: "affects" RELATED []
 xref: RO:0002418
 is_transitive: true
 is_a: causal_relation_between_processes ! causal relation between processes
@@ -278903,12 +279972,16 @@ id: causally_upstream_of_or_within,_negative_effect
 name: causally upstream of or within, negative effect
 xref: RO:0004046
 is_a: causally_upstream_of_or_within ! causally upstream of or within
+created_by: cjm
+creation_date: 2018-03-13T23:55:05Z
 
 [Typedef]
 id: causally_upstream_of_or_within,_positive_effect
 name: causally upstream of or within, positive effect
 xref: RO:0004047
 is_a: causally_upstream_of_or_within ! causally upstream of or within
+created_by: cjm
+creation_date: 2018-03-13T23:55:19Z
 
 [Typedef]
 id: channel_for
@@ -278934,6 +280007,7 @@ is_transitive: true
 id: characteristic_of
 name: characteristic of
 def: "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence." []
+def: "a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence" []
 xref: RO:0000052
 is_functional: true
 is_a: characteristic_of_part_of ! characteristic of part of
@@ -278943,6 +280017,7 @@ inverse_of: bearer_of ! has characteristic
 id: characteristic_of_part_of
 name: characteristic of part of
 def: "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." []
+def: "q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w." []
 xref: RO:0002314
 holds_over_chain: characteristic_of part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
 is_a: depends_on ! depends on
@@ -278975,11 +280050,12 @@ is_a: child_nucleus_of ! child nucleus of
 id: composed_primarily_of
 name: composed primarily of
 def: "x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y." []
+def: "x composed_primarily_of y iff: more than half of the mass of x is made from parts of y" []
 def: "x composed_primarily_of y iff: more than half of the mass of x is made from parts of y." []
 xref: RO:0002473
 domain: BFO:0000040 ! material entity
 range: BFO:0000040 ! material entity
-is_a: has_part ! has part
+is_a: has_part ! has_part
 
 [Typedef]
 id: conduit_for
@@ -279032,6 +280108,7 @@ xref: RO:0001019
 id: contains_process
 name: contains process
 def: "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" []
+comment: Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant
 xref: BFO:0000067
 
 [Typedef]
@@ -279118,6 +280195,7 @@ id: deep_to
 name: deep to
 name: deep_to
 def: "Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines." [BSPO:cjm]
+def: "Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines." [http://orcid.org/0000-0002-6601-2165]
 xref: BSPO:0000107
 is_transitive: true
 inverse_of: superficial_to ! superficial_to
@@ -279160,6 +280238,7 @@ is_metadata_tag: true
 id: developmentally_contributes_to
 name: developmentally contributes to
 def: "inverse of has developmental contribution from" []
+subset: RO:0002259
 xref: RO:0002255
 holds_over_chain: develops_into part_of
 is_a: developmentally_succeeded_by ! developmentally succeeded by
@@ -279189,6 +280268,7 @@ is_a: has_potential_to_developmentally_induce ! has potential to developmentally
 id: developmentally_preceded_by
 name: developmentally preceded by
 def: "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" []
+comment: This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from
 xref: RO:0002258
 domain: BFO:0000002 ! continuant
 range: BFO:0000002 ! continuant
@@ -279228,6 +280308,7 @@ is_transitive: true
 is_a: developmentally_preceded_by ! developmentally preceded by
 is_a: has_developmental_contribution_from ! has developmental contribution from
 inverse_of: develops_into ! develops into
+transitive_over: part_of ! part_of
 
 [Typedef]
 id: develops_from_part_of
@@ -279251,6 +280332,7 @@ is_a: developmentally_preceded_by ! developmentally preceded by
 id: develops_into
 name: develops into
 def: "inverse of develops from" []
+subset: RO:0002259
 xref: RO:0002203
 is_transitive: true
 is_a: developmentally_succeeded_by ! developmentally succeeded by
@@ -279279,11 +280361,16 @@ def: "Process(P2) is directly negatively regulated by process(P1) iff: P1 negati
 xref: RO:0002023
 is_a: directly_regulated_by ! directly regulated by
 inverse_of: directly_negatively_regulates ! directly negatively regulates
+created_by: dos
+creation_date: 2017-09-17T13:52:38Z
 
 [Typedef]
 id: directly_negatively_regulates
 name: directly negatively regulates
 def: "Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2." []
+subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
+subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
+subset: http://purl.obolibrary.org/obo/valid_for_gocam
 xref: RO:0002630
 is_a: directly_regulates ! directly regulates
 is_a: negatively_regulates ! negatively regulates
@@ -279292,6 +280379,7 @@ is_a: negatively_regulates ! negatively regulates
 id: directly_negatively_regulates_activity_of
 name: directly negatively regulates activity of
 def: "The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B." []
+synonym: "molecularly decreases activity of" EXACT []
 xref: RO:0002449
 domain: BFO:0000040 ! material entity
 range: BFO:0000040 ! material entity
@@ -279304,11 +280392,16 @@ def: "Process(P2) is directly postively regulated by process(P1) iff: P1 positiv
 xref: RO:0002024
 is_a: directly_regulated_by ! directly regulated by
 inverse_of: directly_positively_regulates ! directly positively regulates
+created_by: dos
+creation_date: 2017-09-17T13:52:47Z
 
 [Typedef]
 id: directly_positively_regulates
 name: directly positively regulates
 def: "Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2." []
+subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
+subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
+subset: http://purl.obolibrary.org/obo/valid_for_gocam
 xref: RO:0002629
 is_a: directly_regulates ! directly regulates
 is_a: positively_regulates ! positively regulates
@@ -279317,6 +280410,7 @@ is_a: positively_regulates ! positively regulates
 id: directly_positively_regulates_activity_of
 name: directly positively regulates activity of
 def: "The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B." []
+synonym: "molecularly increases activity of" EXACT []
 xref: RO:0002450
 domain: BFO:0000040 ! material entity
 range: BFO:0000040 ! material entity
@@ -279325,14 +280419,20 @@ is_a: directly_regulates_activity_of ! directly regulates activity of
 [Typedef]
 id: directly_regulated_by
 name: directly regulated by
+comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2. {xref="GOC:dos"}
 xref: RO:0002022
 is_a: regulated_by ! regulated by
 inverse_of: directly_regulates ! directly regulates
+created_by: dos
+creation_date: 2017-09-17T13:52:24Z
 
 [Typedef]
 id: directly_regulates
 name: directly regulates
 def: "Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2." []
+subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
+subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
+subset: http://purl.obolibrary.org/obo/valid_for_gocam
 xref: RO:0002578
 is_a: immediately_causally_upstream_of ! immediately causally upstream of
 is_a: regulates ! regulates
@@ -279341,6 +280441,7 @@ is_a: regulates ! regulates
 id: directly_regulates_activity_of
 name: directly regulates activity of
 def: "The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.\n\nA and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B." []
+synonym: "molecularly controls" EXACT []
 xref: RO:0002448
 domain: BFO:0000040 ! material entity
 range: BFO:0000040 ! material entity
@@ -279379,6 +280480,7 @@ id: distalmost_part_of
 name: distalmost part of
 name: distalmost_part_of
 def: "X distalmost part of Y <=> X is in distal side of Y and X is adjacent to the distal boundary of Y" [https://orcid.org/0000-0002-6601-2165]
+def: "X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y" [https://orcid.org/0000-0002-6601-2165]
 def: "X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y." [https://orcid.org/0000-0002-6601-2165]
 xref: BSPO:0001108
 is_a: in_distal_side_of ! in distal side of
@@ -279459,6 +280561,7 @@ is_metadata_tag: true
 id: enabled_by
 name: enabled by
 def: "inverse of enables" []
+subset: http://purl.obolibrary.org/obo/valid_for_gocam
 xref: RO:0002333
 is_a: functionally_related_to ! functionally related to
 is_a: has_participant ! has participant
@@ -279466,11 +280569,12 @@ is_a: has_participant ! has participant
 [Typedef]
 id: enables
 name: enables
+subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
 xref: RO:0002327
 is_a: capable_of ! capable of
 inverse_of: enabled_by ! enabled by
 transitive_over: has_component_activity ! has component activity
-transitive_over: has_part ! has part
+transitive_over: has_part ! has_part
 
 [Typedef]
 id: enables_subfunction
@@ -279479,6 +280583,8 @@ def: "Holds between an entity and an process P where the entity enables some lar
 xref: RO:0004031
 holds_over_chain: enables has_part
 is_a: functionally_related_to ! functionally related to
+created_by: cjm
+creation_date: 2018-01-25T23:20:13Z
 
 [Typedef]
 id: ends
@@ -279494,6 +280600,8 @@ inverse_of: ends_with ! ends with
 [Typedef]
 id: ends_after
 name: ends after
+comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)
+subset: ro-eco
 xref: RO:0002086
 is_transitive: true
 is_a: temporally_related_to ! temporally related to
@@ -279504,7 +280612,7 @@ name: ends with
 def: "x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." []
 xref: RO:0002230
 is_transitive: true
-is_a: has_part ! has part
+is_a: has_part ! has_part
 is_a: temporally_related_to ! temporally related to
 
 [Typedef]
@@ -279696,15 +280804,19 @@ id: has_component
 name: has component
 namespace: protein
 def: "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." []
+subset: ro-eco
 xref: RO:0002180
 is_transitive: false
-is_a: has_part ! has part
+is_a: has_part ! has_part
 
 [Typedef]
 id: has_component_activity
 name: has component activity
+comment: A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.
 xref: RO:0002017
 is_a: has_component_process ! has component process
+created_by: dos
+creation_date: 2017-05-24T09:44:33Z
 
 [Typedef]
 id: has_component_process
@@ -279714,6 +280826,8 @@ xref: RO:0002018
 domain: BFO:0000015 ! process
 range: BFO:0000015 ! process
 is_a: has_component ! has component
+created_by: dos
+creation_date: 2017-05-24T09:49:21Z
 
 [Typedef]
 id: has_derived_by_descendant
@@ -279758,9 +280872,13 @@ inverse_of: disposition_of ! disposition of
 id: has_effector_activity
 name: has effector activity
 def: "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674),  A 'has component activity' B and B is the effector (output function) of B.  Each compound function has only one effector activity." [GOC:dos]
+comment: This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.
 xref: RO:0002025
 is_functional: true
 is_a: has_component_activity ! has component activity
+is_a: regulates ! regulates
+created_by: dos
+creation_date: 2017-09-22T14:14:36Z
 
 [Typedef]
 id: has_end_location
@@ -279801,8 +280919,13 @@ is_transitive: false
 id: has_input
 name: has input
 def: "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." []
+subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
+subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
+subset: http://purl.obolibrary.org/obo/valid_for_gocam
+subset: ro-eco
 xref: RO:0002233
 domain: BFO:0000015 ! process
+range: BFO:0000040 ! material entity
 holds_over_chain: starts_with has_input
 is_a: has_participant ! has participant
 inverse_of: input_of ! input of
@@ -279812,7 +280935,7 @@ id: has_member
 name: has member
 def: "has member is a mereological relation between a collection and an item." []
 xref: RO:0002351
-is_a: has_part ! has part
+is_a: has_part ! has_part
 
 [Typedef]
 id: has_muscle_antagonist
@@ -279848,9 +280971,12 @@ is_a: biomechanically_related_to ! biomechanically related to
 id: has_negative_regulatory_component_activity
 name: has negative regulatory component activity
 def: "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." []
+comment: By convention GO molecular functions are classified by their effector function.  Internal regulatory functions are treated as components.  For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'.
 xref: RO:0002014
 is_a: has_regulatory_component_activity ! has regulatory component activity
 is_a: negatively_regulated_by ! negatively regulated by
+created_by: dos
+creation_date: 2017-05-24T09:31:01Z
 
 [Typedef]
 id: has_no_connections_with
@@ -279880,14 +281006,18 @@ inverse_of: output_of ! output of
 id: has_part
 name: has part
 name: has_part
+namespace: chebi_ontology
 namespace: external
 namespace: protein
 namespace: quality
 def: "a core relation that holds between a whole and its part" []
+def: "Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2." [PATOC:CJM]
+comment: We use the has_part relation to relate complex qualities to more primitive ones. A complex quality is a collection of qualities. The complex quality cannot exist without the sub-qualities. For example, the quality 'swollen' necessarily comes with the qualities of 'protruding' and 'increased size'.
 subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
 subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
 subset: http://purl.obolibrary.org/obo/valid_for_gocam
 xref: BFO:0000051
+is_cyclic: false
 is_transitive: true
 is_a: overlaps ! overlaps
 
@@ -279904,6 +281034,7 @@ is_a: functionally_related_to ! functionally related to
 id: has_part_that_occurs_in
 name: has part that occurs in
 def: "p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c." []
+subset: ro-eco
 xref: RO:0002479
 domain: BFO:0000003 ! occurrent
 range: BFO:0000004 ! independent continuant
@@ -279924,9 +281055,12 @@ holds_over_chain: has_part has_participant
 id: has_positive_regulatory_component_activity
 name: has positive regulatory component activity
 def: "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." []
+comment: By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components.  So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.
 xref: RO:0002015
 is_a: has_regulatory_component_activity ! has regulatory component activity
 is_a: positively_regulated_by ! positively regulated by
+created_by: dos
+creation_date: 2017-05-24T09:31:17Z
 
 [Typedef]
 id: has_potential_to_develop_into
@@ -279976,6 +281110,8 @@ def: "A 'has regulatory component activity' B if A and B are GO molecular functi
 xref: RO:0002013
 is_a: has_component_activity ! has component activity
 is_a: regulated_by ! regulated by
+created_by: dos
+creation_date: 2017-05-24T09:30:46Z
 
 [Typedef]
 id: has_relational_adjective
@@ -279986,10 +281122,13 @@ is_metadata_tag: true
 [Typedef]
 id: has_role
 name: has role
+namespace: chebi_ontology
 def: "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence" []
 xref: RO:0000087
 domain: BFO:0000004 ! independent continuant
 range: BFO:0000023 ! role
+is_cyclic: false
+is_transitive: false
 is_a: bearer_of ! has characteristic
 
 [Typedef]
@@ -280004,7 +281143,7 @@ domain: CARO:0000003
 domain: UBERON:0000475 ! organism subdivision
 range: CARO:0000006 {http://purl.obolibrary.org/obo/IAO_0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."}
 range: UBERON:0010912 ! subdivision of skeleton
-is_a: has_part ! has part
+is_a: has_part ! has_part
 inverse_of: skeleton_of ! skeleton of
 is_asymmetric: true
 
@@ -280111,7 +281250,9 @@ is_a: posterior_to ! posterior to
 [Typedef]
 id: immediately_preceded_by
 name: immediately preceded by
+def: "X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)" []
 def: "X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)." []
+comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
 synonym: "directly preceded by" EXACT []
 synonym: "is directly preceded by" EXACT []
 synonym: "is immediately preceded by" EXACT [SIO:000251]
@@ -280124,6 +281265,8 @@ inverse_of: immediately_precedes ! immediately precedes
 [Typedef]
 id: immediately_precedes
 name: immediately precedes
+comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)
+subset: ro-eco
 xref: RO:0002090
 holds_over_chain: ends_with starts_with
 is_a: precedes ! precedes
@@ -280206,6 +281349,7 @@ id: in_lateral_side_of
 name: in lateral side of
 name: in_lateral_side_of
 def: "X in lateral side of Y <=> if X is in left side of Y or X is in right side of Y. X is often, but not always a paired structure" [UBERON:cjm]
+def: "X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure" [https://orcid.org/0000-0002-6601-2165]
 def: "X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure." [https://orcid.org/0000-0002-6601-2165]
 xref: BSPO:0000126
 is_a: part_of ! part_of
@@ -280333,6 +281477,8 @@ transitive_over: part_of ! part_of
 id: input_of
 name: input of
 def: "inverse of has input" []
+subset: ro-eco
+subset: RO:0002259
 xref: RO:0002352
 is_a: functionally_related_to ! functionally related to
 is_a: participates_in ! participates in
@@ -280347,6 +281493,8 @@ is_a: helper_property_(not_for_use_in_curation) ! helper property (not for use i
 id: interacts_with
 name: interacts with
 def: "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." []
+subset: ro-eco
+synonym: "in pairwise interaction with" EXACT []
 xref: RO:0002434
 domain: BFO:0000040 ! material entity
 range: BFO:0000040 ! material entity
@@ -280412,6 +281560,7 @@ is_a: involved_in_or_involved_in_regulation_of ! involved in or involved in regu
 id: is_active_in
 name: is active in
 def: "c executes activity in d if and only if c enables p and p occurs_in d.  Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." [GOC:cjm, GOC:dos]
+synonym: "enables activity in" EXACT []
 xref: RO:0002432
 holds_over_chain: enables occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
 is_a: functionally_related_to ! functionally related to
@@ -280517,6 +281666,7 @@ is_class_level: true
 id: negatively_regulated_by
 name: negatively regulated by
 def: "inverse of negatively regulates" []
+subset: RO:0002259
 xref: RO:0002335
 is_a: regulated_by ! regulated by
 
@@ -280524,6 +281674,10 @@ is_a: regulated_by ! regulated by
 id: negatively_regulates
 name: negatively regulates
 def: "Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2." []
+subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
+subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
+subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
+subset: http://purl.obolibrary.org/obo/valid_for_gocam
 xref: RO:0002212
 holds_over_chain: ends_with negatively_regulates
 is_a: causally_upstream_of,_negative_effect ! causally upstream of, negative effect
@@ -280546,6 +281700,10 @@ is_class_level: true
 id: occurs_in
 name: occurs in
 def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" []
+comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant
+subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
+subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
+subset: http://purl.obolibrary.org/obo/valid_for_gocam
 xref: BFO:0000066
 domain: BFO:0000003 ! occurrent
 range: BFO:0000004 ! independent continuant
@@ -280589,6 +281747,9 @@ is_a: participates_in ! participates in
 id: overlaps
 name: overlaps
 def: "x overlaps y if and only if there exists some z such that x has part z and z part of y" []
+subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
+subset: http://purl.obolibrary.org/obo/valid_for_gocam
+subset: ro-eco
 xref: RO:0002131
 holds_over_chain: has_part overlaps
 holds_over_chain: has_part part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
@@ -280596,6 +281757,7 @@ holds_over_chain: part_of part_of
 is_a: mereotopologically_related_to ! mereotopologically related to
 transitive_over: part_of ! part_of
 expand_expression_to: "BFO_0000051 some (BFO_0000050 some ?Y)" []
+expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)" []
 
 [Typedef]
 id: paired_appendage_number
@@ -280619,7 +281781,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_gocam
 xref: BFO:0000050
 is_transitive: true
 is_a: overlaps ! overlaps
-inverse_of: has_part ! has part
+inverse_of: has_part ! has_part
 
 [Typedef]
 id: part_of_developmental_precursor_of
@@ -280670,6 +281832,7 @@ is_a: molecularly_interacts_with ! molecularly interacts with
 id: positively_regulated_by
 name: positively regulated by
 def: "inverse of positively regulates" []
+subset: RO:0002259
 xref: RO:0002336
 is_a: regulated_by ! regulated by
 
@@ -280677,6 +281840,10 @@ is_a: regulated_by ! regulated by
 id: positively_regulates
 name: positively regulates
 def: "Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2." []
+subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
+subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
+subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
+subset: http://purl.obolibrary.org/obo/valid_for_gocam
 xref: RO:0002213
 holds_over_chain: ends_with positively_regulates
 holds_over_chain: negatively_regulates negatively_regulates
@@ -280740,7 +281907,9 @@ id: preceded_by
 name: preceded by
 name: preceded_by
 def: "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." []
+def: "X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)" []
 def: "X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)." []
+subset: ro-eco
 synonym: "is preceded by" EXACT [SIO:000249]
 synonym: "takes place after" EXACT [Allen:precedes]
 xref: BFO:0000062
@@ -280755,6 +281924,7 @@ inverse_of: precedes ! precedes
 id: precedes
 name: precedes
 def: "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." []
+subset: ro-eco
 xref: BFO:0000063
 domain: BFO:0000003 ! occurrent
 range: BFO:0000003 ! occurrent
@@ -280838,6 +282008,7 @@ id: proximalmost_part_of
 name: proximalmost part of
 name: proximalmost_part_of
 def: "X proximalmost part of Y <=> X is in proximal side of Y and X is adjacent to the proximal boundary of Y" [https://orcid.org/0000-0002-6601-2165]
+def: "X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y" [https://orcid.org/0000-0002-6601-2165]
 def: "X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y." [https://orcid.org/0000-0002-6601-2165]
 xref: BSPO:0001106
 is_a: in_proximal_side_of ! in_proximal_side_of
@@ -280862,6 +282033,7 @@ is_metadata_tag: true
 id: regulated_by
 name: regulated by
 def: "inverse of regulates" []
+subset: RO:0002259
 xref: RO:0002334
 domain: BFO:0000015 ! process
 range: BFO:0000015 ! process
@@ -280871,7 +282043,12 @@ is_a: causally_downstream_of_or_within ! causally downstream of or within
 [Typedef]
 id: regulates
 name: regulates
+namespace: external
 def: "process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2." []
+subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
+subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
+subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
+subset: http://purl.obolibrary.org/obo/valid_for_gocam
 xref: RO:0002211
 domain: BFO:0000015 ! process
 range: BFO:0000015 ! process
@@ -281019,7 +282196,7 @@ name: starts with
 def: "x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." []
 xref: RO:0002224
 is_transitive: true
-is_a: has_part ! has part
+is_a: has_part ! has_part
 is_a: temporally_related_to ! temporally related to
 
 [Typedef]
@@ -281039,6 +282216,7 @@ xref: subdivision_of
 id: superficial_to
 name: superficial to
 name: superficial_to
+def: "Near the outer surface of the organism. Thus, skin is superficial to the muscle layer." [http://orcid.org/0000-0002-6601-2165]
 def: "Near the outer surface of the organism. Thus, skin is superficial to the muscle layer." [BSPO:cjm]
 xref: BSPO:0000108
 is_transitive: true
@@ -281058,6 +282236,7 @@ is_a: connected_to ! connected to
 id: surrounded_by
 name: surrounded by
 def: "x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x" []
+def: "x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y" [https://orcid.org/0000-0002-6601-2165]
 def: "x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y." [https://orcid.org/0000-0002-6601-2165]
 xref: RO:0002219
 is_a: adjacent_to ! adjacent to
@@ -281067,6 +282246,7 @@ inverse_of: surrounds ! surrounds
 id: surrounds
 name: surrounds
 def: "inverse of surrounded by" []
+def: "inverse of surrounded_by" [https://orcid.org/0000-0002-6601-2165]
 def: "inverse of surrounded_by." [https://orcid.org/0000-0002-6601-2165]
 xref: RO:0002221
 is_a: adjacent_to ! adjacent to
@@ -281087,6 +282267,8 @@ is_metadata_tag: true
 [Typedef]
 id: temporally_related_to
 name: temporally related to
+comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.
+subset: ro-eco
 xref: RO:0002222
 domain: BFO:0000003 ! occurrent
 range: BFO:0000003 ! occurrent