From 41c24dfb9c0cade8e6a3489274442d3d62673afc Mon Sep 17 00:00:00 2001
From: Aleix Puig <94959119+aleixpuigb@users.noreply.github.com>
Date: Tue, 14 Jan 2025 11:32:34 +0000
Subject: [PATCH] Refresh imports for Uberon release (#3461)
* Refresh imports for Uberon release
* Remove UBERON_0011940 from the HRA subset
This term was wrongly added into HRA (human don't have whiskers) and it needs to be removed from the ASCT+B tables
---
src/mappings/biomappings.sssom.tsv | 40 +-
src/mappings/cl.sssom.tsv | 2855 +++++++++++-----------
src/mappings/fbbt.sssom.tsv | 24 +-
src/ontology/components/hra_subset.owl | 36 +-
src/ontology/components/mappings.owl | 1806 +++++++++++++-
src/ontology/imports/local-cl.owl | 3004 ++++++++++++++++++------
src/ontology/imports/local-fbbt.owl | 2526 ++++++++++----------
src/ontology/imports/local-fbdv.owl | 24 +-
src/ontology/imports/local-wbbt.owl | 2 +-
src/ontology/imports/local-wbls.owl | 4 +-
src/ontology/imports/merged_import.owl | 1678 +++++++++----
11 files changed, 8051 insertions(+), 3948 deletions(-)
diff --git a/src/mappings/biomappings.sssom.tsv b/src/mappings/biomappings.sssom.tsv
index 3ff7de99e..5cee6c511 100644
--- a/src/mappings/biomappings.sssom.tsv
+++ b/src/mappings/biomappings.sssom.tsv
@@ -1,26 +1,24 @@
#curie_map:
-# BTO: "http://purl.obolibrary.org/obo/BTO_"
-# IDOMAL: "http://purl.obolibrary.org/obo/IDOMAL_"
-# UBERON: "http://purl.obolibrary.org/obo/UBERON_"
-# VO: "http://purl.obolibrary.org/obo/VO_"
-# mesh: "http://id.nlm.nih.gov/mesh/"
-# obo: "http://purl.obolibrary.org/obo/"
-# orcid: "https://orcid.org/"
-#mapping_set_id: "https://w3id.org/biopragmatics/biomappings/sssom/biomappings.sssom.tsv"
-#mapping_set_version: "0.3.8.dev0"
-#mapping_set_title: "Biomappings"
-#mapping_set_description: "Biomappings is a repository of community curated and predicted equivalences and related mappings between named biological entities that are not available from primary sources. It's also a place where anyone can contribute curations of predicted mappings or their own novel mappings."
+# BTO: http://purl.obolibrary.org/obo/BTO_
+# IDOMAL: http://purl.obolibrary.org/obo/IDOMAL_
+# UBERON: http://purl.obolibrary.org/obo/UBERON_
+# VO: http://purl.obolibrary.org/obo/VO_
+# mesh: http://id.nlm.nih.gov/mesh/
+# orcid: https://orcid.org/
+#mapping_set_id: https://w3id.org/biopragmatics/biomappings/sssom/biomappings.sssom.tsv
+#mapping_set_version: 0.3.8.dev0
+#mapping_set_title: Biomappings
+#mapping_set_description: Biomappings is a repository of community curated and predicted equivalences and related mappings between named biological entities that are not available from primary sources. It's also a place where anyone can contribute curations of predicted mappings or their own novel mappings.
#creator_id:
-# - "orcid:0000-0001-9439-5346"
-# - "orcid:0000-0002-1216-4761"
-# - "orcid:0000-0002-2046-6145"
-# - "orcid:0000-0002-2627-0696"
-# - "orcid:0000-0002-6601-2165"
-# - "orcid:0000-0003-1307-2508"
-# - "orcid:0000-0003-4423-4370"
-#license: "https://creativecommons.org/publicdomain/zero/1.0/"
-#subject_source: "obo:uberon/core.owl"
-#mapping_provider: "https://github.com/biopragmatics/biomappings"
+# - orcid:0000-0001-9439-5346
+# - orcid:0000-0002-1216-4761
+# - orcid:0000-0002-2046-6145
+# - orcid:0000-0002-2627-0696
+# - orcid:0000-0002-6601-2165
+# - orcid:0000-0003-1307-2508
+# - orcid:0000-0003-4423-4370
+#license: https://creativecommons.org/publicdomain/zero/1.0/
+#mapping_provider: https://github.com/biopragmatics/biomappings
subject_id subject_label predicate_id predicate_modifier object_id object_label mapping_justification author_id mapping_tool confidence
UBERON:0000016 endocrine pancreas skos:exactMatch mesh:D007515 Islets of Langerhans semapv:LexicalMatching generate_uberon_mesh_mappings.py 0.9
UBERON:0000017 exocrine pancreas skos:exactMatch mesh:D046790 Pancreas, Exocrine semapv:ManualMappingCuration orcid:0000-0001-9439-5346
diff --git a/src/mappings/cl.sssom.tsv b/src/mappings/cl.sssom.tsv
index 496349d47..1c4efaf7d 100644
--- a/src/mappings/cl.sssom.tsv
+++ b/src/mappings/cl.sssom.tsv
@@ -1,1436 +1,1423 @@
#curie_map:
-# AAO: "http://purl.obolibrary.org/obo/AAO_"
-# CARO: "http://purl.obolibrary.org/obo/CARO_"
-# CL: "http://purl.obolibrary.org/obo/CL_"
-# EHDAA2: "http://purl.obolibrary.org/obo/EHDAA2_"
-# EMAPA: "http://purl.obolibrary.org/obo/EMAPA_"
-# EV: "http://purl.obolibrary.org/obo/EV_"
-# FBbt: "http://purl.obolibrary.org/obo/FBbt_"
-# FMA: "http://purl.org/sig/ont/fma/fma"
-# GO: "http://purl.obolibrary.org/obo/GO_"
-# KUPO: "http://purl.obolibrary.org/obo/KUPO_"
-# MA: "http://purl.obolibrary.org/obo/MA_"
-# NCIT: "http://purl.obolibrary.org/obo/NCIT_"
-# ORCID: "https://orcid.org/"
-# SCTID: "http://purl.obolibrary.org/obo/SCTID_"
-# VHOG: "http://purl.obolibrary.org/obo/VHOG_"
-# VSAO: "http://purl.obolibrary.org/obo/VSAO_"
-# WBbt: "http://purl.obolibrary.org/obo/WBbt_"
-# XAO: "http://purl.obolibrary.org/obo/XAO_"
-# ZFA: "http://purl.obolibrary.org/obo/ZFA_"
-# obo: "http://purl.obolibrary.org/obo/"
-#mapping_set_id: "http://purl.obolibrary.org/obo/cl/cl.sssom.tsv"
+# AAO: http://purl.obolibrary.org/obo/AAO_
+# CARO: http://purl.obolibrary.org/obo/CARO_
+# CL: http://purl.obolibrary.org/obo/CL_
+# EHDAA2: http://purl.obolibrary.org/obo/EHDAA2_
+# EMAPA: http://purl.obolibrary.org/obo/EMAPA_
+# EV: http://purl.obolibrary.org/obo/EV_
+# FBbt: http://purl.obolibrary.org/obo/FBbt_
+# FMA: http://purl.org/sig/ont/fma/fma
+# GO: http://purl.obolibrary.org/obo/GO_
+# KUPO: http://purl.obolibrary.org/obo/KUPO_
+# MA: http://purl.obolibrary.org/obo/MA_
+# NCIT: http://purl.obolibrary.org/obo/NCIT_
+# ORCID: https://orcid.org/
+# SCTID: http://purl.obolibrary.org/obo/SCTID_
+# VHOG: http://purl.obolibrary.org/obo/VHOG_
+# VSAO: http://purl.obolibrary.org/obo/VSAO_
+# WBbt: http://purl.obolibrary.org/obo/WBbt_
+# XAO: http://purl.obolibrary.org/obo/XAO_
+# ZFA: http://purl.obolibrary.org/obo/ZFA_
+# obo: http://purl.obolibrary.org/obo/
+#mapping_set_id: http://purl.obolibrary.org/obo/cl/cl.sssom.tsv
#creator_id:
-# - "ORCID:0000-0002-1373-1705"
-# - "ORCID:0000-0002-6095-8718"
-#license: "http://creativecommons.org/licenses/by/4.0/"
-subject_id subject_label predicate_id object_id object_label mapping_justification subject_source object_source mapping_date
-CL:0000000 semapv:crossSpeciesExactMatch FBbt:00007002 cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000000 semapv:crossSpeciesExactMatch ZFA:0009000 cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000000 cell skos:broadMatch VHOG:0001533 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000000 cell skos:exactMatch GO:0005623 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000000 cell semapv:crossSpeciesExactMatch KUPO:0000002 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000000 cell semapv:crossSpeciesExactMatch WBbt:0004017 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000000 cell semapv:crossSpeciesExactMatch XAO:0003012 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000000 cell semapv:crossSpeciesExactMatch FMA:68646 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000006 semapv:crossSpeciesExactMatch ZFA:0009001 receptor cell (sensu Animalia) semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000007 semapv:crossSpeciesExactMatch ZFA:0009002 early embryonic cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000008 semapv:crossSpeciesExactMatch ZFA:0007091 migratory cranial neural crest cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000011 semapv:crossSpeciesExactMatch ZFA:0007095 migratory trunk neural crest cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000014 semapv:crossSpeciesExactMatch FBbt:00004861 germline stem cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000014 semapv:crossSpeciesExactMatch ZFA:0005956 germline stem cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000015 male germ cell skos:broadMatch VHOG:0001531 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000015 male germ cell semapv:crossSpeciesExactMatch MA:0002765 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000015 male germ cell semapv:crossSpeciesExactMatch FMA:72290 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000016 semapv:crossSpeciesExactMatch FBbt:00004929 male germline stem cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000017 semapv:crossSpeciesExactMatch FBbt:00004936 spermatocyte semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000017 semapv:crossSpeciesExactMatch ZFA:0009005 spermatocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000017 spermatocyte semapv:crossSpeciesExactMatch EMAPA:31484 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000017 spermatocyte semapv:crossSpeciesExactMatch WBbt:0006799 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000017 spermatocyte semapv:crossSpeciesExactMatch FMA:84049 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000018 semapv:crossSpeciesExactMatch FBbt:00004942 spermatid semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000018 semapv:crossSpeciesExactMatch ZFA:0005769 spermatid semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000018 spermatid semapv:crossSpeciesExactMatch EMAPA:31486 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000018 spermatid semapv:crossSpeciesExactMatch WBbt:0006800 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000018 spermatid semapv:crossSpeciesExactMatch FMA:72294 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000019 semapv:crossSpeciesExactMatch FBbt:00004954 spermatozoon semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000019 semapv:crossSpeciesExactMatch ZFA:0009006 sperm semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000019 sperm semapv:crossSpeciesExactMatch WBbt:0006798 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000019 sperm semapv:crossSpeciesExactMatch FMA:67338 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000020 semapv:crossSpeciesExactMatch FBbt:00004934 primary gonial cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000020 semapv:crossSpeciesExactMatch FBbt:00004935 spermatogonium semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000020 semapv:crossSpeciesExactMatch ZFA:0009007 spermatogonium semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000020 spermatogonium semapv:crossSpeciesExactMatch EMAPA:31482 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000020 spermatogonium semapv:crossSpeciesExactMatch FMA:72291 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000021 female germ cell skos:broadMatch VHOG:0001530 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000021 female germ cell semapv:crossSpeciesExactMatch MA:0000388 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000022 semapv:crossSpeciesExactMatch FBbt:00004873 female germline stem cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000023 semapv:crossSpeciesExactMatch FBbt:00004886 oocyte semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000023 semapv:crossSpeciesExactMatch ZFA:0001109 oocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000023 oocyte semapv:crossSpeciesExactMatch WBbt:0006797 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000023 oocyte semapv:crossSpeciesExactMatch FMA:18644 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000024 semapv:crossSpeciesExactMatch ZFA:0005878 oogonia semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000024 oogonial cell semapv:crossSpeciesExactMatch FMA:83673 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000025 semapv:crossSpeciesExactMatch FBbt:00057012 female germline cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000025 semapv:crossSpeciesExactMatch ZFA:0001570 unfertilized egg semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000025 egg cell semapv:crossSpeciesExactMatch FMA:67343 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000026 semapv:crossSpeciesExactMatch FBbt:00004878 nurse cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000029 semapv:crossSpeciesExactMatch ZFA:0009009 neuron neural crest derived semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000030 semapv:crossSpeciesExactMatch ZFA:0009010 glioblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000031 semapv:crossSpeciesExactMatch ZFA:0009011 neuroblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000031 neuroblast (sensu Vertebrata) semapv:crossSpeciesExactMatch FMA:70563 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000032 semapv:crossSpeciesExactMatch ZFA:0009012 neuroplacodal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000034 semapv:crossSpeciesExactMatch ZFA:0005957 stem cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000034 stem cell semapv:crossSpeciesExactMatch FMA:63368 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000035 semapv:crossSpeciesExactMatch ZFA:0009013 single fate stem cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000035 single fate stem cell semapv:crossSpeciesExactMatch FMA:70569 semapv:UnspecifiedMatching obo:cl.owl
-CL:00000365 semapv:crossSpeciesExactMatch ZFA:0005772 fertilized egg semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000037 semapv:crossSpeciesExactMatch ZFA:0009014 hematopoietic stem cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000037 hematopoietic stem cell skos:broadMatch VHOG:0001485 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000037 hematopoietic stem cell semapv:crossSpeciesExactMatch FMA:86475 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000038 semapv:crossSpeciesExactMatch ZFA:0009015 erythroid progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000039 semapv:crossSpeciesExactMatch ZFA:0009016 germ line cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000040 semapv:crossSpeciesExactMatch ZFA:0009017 monoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000040 monoblast semapv:crossSpeciesExactMatch FMA:83553 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000042 semapv:crossSpeciesExactMatch ZFA:0009018 neutrophilic myeloblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000047 semapv:crossSpeciesExactMatch ZFA:0009019 neuronal stem cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000047 neural stem cell semapv:crossSpeciesExactMatch FMA:86684 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000048 semapv:crossSpeciesExactMatch ZFA:0009020 multi fate stem cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000048 multi fate stem cell semapv:crossSpeciesExactMatch FMA:84789 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000049 semapv:crossSpeciesExactMatch ZFA:0009021 common myeloid progenitor semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000050 semapv:crossSpeciesExactMatch ZFA:0009022 megakaryocyte erythroid progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000051 semapv:crossSpeciesExactMatch ZFA:0009023 common lymphoid progenitor semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000052 semapv:crossSpeciesExactMatch ZFA:0009024 totipotent stem cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000052 totipotent stem cell semapv:crossSpeciesExactMatch FMA:84790 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000055 non-terminally differentiated cell semapv:crossSpeciesExactMatch FMA:84782 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000056 semapv:crossSpeciesExactMatch FBbt:00005083 myoblast semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000056 semapv:crossSpeciesExactMatch ZFA:0009025 myoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000056 myoblast skos:broadMatch VHOG:0001529 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000056 myoblast semapv:crossSpeciesExactMatch FMA:70335 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000057 semapv:crossSpeciesExactMatch ZFA:0009026 fibroblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000057 fibroblast skos:broadMatch VHOG:0001482 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000057 fibroblast skos:narrowMatch NCIT:C12482 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000057 fibroblast semapv:crossSpeciesExactMatch FMA:63877 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000058 semapv:crossSpeciesExactMatch ZFA:0009027 chondroblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000058 chondroblast semapv:crossSpeciesExactMatch FMA:66783 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000059 ameloblast semapv:crossSpeciesExactMatch FMA:70576 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000060 semapv:crossSpeciesExactMatch ZFA:0009029 odontoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000060 odontoblast semapv:crossSpeciesExactMatch FMA:62999 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000061 semapv:crossSpeciesExactMatch ZFA:0009030 cementoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000061 cementoblast semapv:crossSpeciesExactMatch FMA:63002 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000062 semapv:crossSpeciesExactMatch ZFA:0009031 osteoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000062 osteoblast semapv:crossSpeciesExactMatch FMA:66780 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000064 semapv:crossSpeciesExactMatch ZFA:0009032 ciliated cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000064 ciliated cell skos:broadMatch VHOG:0001532 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000064 ciliated cell semapv:crossSpeciesExactMatch XAO:0000031 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000065 semapv:crossSpeciesExactMatch ZFA:0009033 ependymal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000065 ependymal cell semapv:crossSpeciesExactMatch FMA:70550 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000066 semapv:crossSpeciesExactMatch FBbt:00000124 epithelial cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000066 semapv:crossSpeciesExactMatch ZFA:0009034 epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000066 epithelial cell skos:exactMatch CARO:0000077 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000066 epithelial cell semapv:crossSpeciesExactMatch WBbt:0003672 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000066 epithelial cell semapv:crossSpeciesExactMatch FMA:66768 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000067 semapv:crossSpeciesExactMatch ZFA:0009035 ciliated epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000067 ciliated epithelial cell semapv:crossSpeciesExactMatch FMA:70605 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000068 semapv:crossSpeciesExactMatch ZFA:0009372 duct epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000071 semapv:crossSpeciesExactMatch ZFA:0009036 blood vessel endothelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000073 semapv:crossSpeciesExactMatch ZFA:0009037 barrier epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000075 semapv:crossSpeciesExactMatch ZFA:0009038 columnar/cuboidal epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000076 semapv:crossSpeciesExactMatch ZFA:0009039 squamous epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000077 semapv:crossSpeciesExactMatch ZFA:0009040 mesothelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000077 mesothelial cell semapv:crossSpeciesExactMatch FMA:66773 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000078 semapv:crossSpeciesExactMatch ZFA:0009041 peridermal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000079 semapv:crossSpeciesExactMatch ZFA:0009042 stratified epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000080 semapv:crossSpeciesExactMatch ZFA:0009043 circulating cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000081 semapv:crossSpeciesExactMatch ZFA:0009044 blood cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000081 blood cell semapv:crossSpeciesExactMatch FMA:62844 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000083 semapv:crossSpeciesExactMatch ZFA:0009045 epithelial cell of pancreas semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000084 semapv:crossSpeciesExactMatch ZFA:0009046 T cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000084 T cell skos:broadMatch VHOG:0001479 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000084 T cell semapv:crossSpeciesExactMatch FMA:62870 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000091 Kupffer cell semapv:crossSpeciesExactMatch FMA:14656 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000092 semapv:crossSpeciesExactMatch ZFA:0009047 osteoclast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000092 osteoclast semapv:crossSpeciesExactMatch FMA:66781 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000094 semapv:crossSpeciesExactMatch ZFA:0009048 granulocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000094 granulocyte semapv:crossSpeciesExactMatch FMA:62854 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000096 semapv:crossSpeciesExactMatch ZFA:0009049 mature neutrophil semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000097 mast cell semapv:crossSpeciesExactMatch FMA:66784 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000098 semapv:crossSpeciesExactMatch ZFA:0009050 sensory epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000099 semapv:crossSpeciesExactMatch FBbt:00005125 interneuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000099 semapv:crossSpeciesExactMatch ZFA:0009051 interneuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000099 interneuron semapv:crossSpeciesExactMatch WBbt:0005113 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000099 interneuron semapv:crossSpeciesExactMatch FMA:67313 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000100 semapv:crossSpeciesExactMatch FBbt:00005123 motor neuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000100 semapv:crossSpeciesExactMatch ZFA:0009052 motor neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000100 motor neuron semapv:crossSpeciesExactMatch WBbt:0005409 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000100 motor neuron semapv:crossSpeciesExactMatch FMA:83617 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000101 semapv:crossSpeciesExactMatch FBbt:00005124 sensory neuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000101 semapv:crossSpeciesExactMatch ZFA:0009053 sensory neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000101 sensory neuron semapv:crossSpeciesExactMatch WBbt:0005759 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000101 sensory neuron semapv:crossSpeciesExactMatch FMA:84649 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000102 semapv:crossSpeciesExactMatch ZFA:0009054 polymodal neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000103 semapv:crossSpeciesExactMatch ZFA:0009055 bipolar neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000103 bipolar neuron semapv:crossSpeciesExactMatch FMA:67282 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000104 semapv:crossSpeciesExactMatch ZFA:0009056 multipolar neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000104 multipolar neuron semapv:crossSpeciesExactMatch FMA:67287 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000105 semapv:crossSpeciesExactMatch ZFA:0009057 pseudounipolar neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000105 pseudounipolar neuron semapv:crossSpeciesExactMatch FMA:67305 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000106 semapv:crossSpeciesExactMatch ZFA:0009058 unipolar neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000106 unipolar neuron semapv:crossSpeciesExactMatch FMA:67278 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000107 semapv:crossSpeciesExactMatch ZFA:0009059 autonomic neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000107 autonomic neuron semapv:crossSpeciesExactMatch FMA:80121 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000108 semapv:crossSpeciesExactMatch FBbt:00007173 cholinergic neuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000108 semapv:crossSpeciesExactMatch ZFA:0009060 cholinergic neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000108 cholinergic neuron semapv:crossSpeciesExactMatch WBbt:0006840 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000108 cholinergic neuron semapv:crossSpeciesExactMatch FMA:84796 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000109 semapv:crossSpeciesExactMatch ZFA:0009061 adrenergic neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000110 semapv:crossSpeciesExactMatch FBbt:00004101 peptidergic neuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000110 semapv:crossSpeciesExactMatch ZFA:0009062 peptidergic neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000111 semapv:crossSpeciesExactMatch ZFA:0009063 peripheral neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000113 semapv:crossSpeciesExactMatch ZFA:0009064 mononuclear phagocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000114 surface ectodermal cell semapv:crossSpeciesExactMatch FMA:72552 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000115 semapv:crossSpeciesExactMatch ZFA:0009065 endothelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000115 endothelial cell semapv:crossSpeciesExactMatch FMA:66772 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000116 semapv:crossSpeciesExactMatch FBbt:00005128 pioneer neuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000116 semapv:crossSpeciesExactMatch ZFA:0009066 pioneer neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000117 semapv:crossSpeciesExactMatch ZFA:0009067 CNS neuron (sensu Vertebrata) semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000118 semapv:crossSpeciesExactMatch ZFA:0009068 basket cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000119 semapv:crossSpeciesExactMatch ZFA:0009069 Golgi cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000120 semapv:crossSpeciesExactMatch ZFA:0009070 granule cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000121 semapv:crossSpeciesExactMatch ZFA:0009071 Purkinje cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000121 Purkinje cell semapv:crossSpeciesExactMatch FMA:67969 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000122 semapv:crossSpeciesExactMatch ZFA:0009072 stellate cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000125 semapv:crossSpeciesExactMatch FBbt:00005144 glial cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000125 semapv:crossSpeciesExactMatch ZFA:0009073 glial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000125 glial cell semapv:crossSpeciesExactMatch FMA:54536 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000126 semapv:crossSpeciesExactMatch ZFA:0009074 macroglial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000126 macroglial cell semapv:crossSpeciesExactMatch FMA:54538 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000127 semapv:crossSpeciesExactMatch ZFA:0009075 astrocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000127 astrocyte semapv:crossSpeciesExactMatch FMA:54537 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000128 semapv:crossSpeciesExactMatch ZFA:0009076 oligodendrocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000128 oligodendrocyte semapv:crossSpeciesExactMatch FMA:54540 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000129 semapv:crossSpeciesExactMatch ZFA:0009077 microglial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000129 microglial cell semapv:crossSpeciesExactMatch FMA:54539 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000131 semapv:crossSpeciesExactMatch ZFA:0009078 gut endothelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000132 semapv:crossSpeciesExactMatch ZFA:0009079 corneal endothelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000132 corneal endothelial cell semapv:crossSpeciesExactMatch FMA:70614 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000133 semapv:crossSpeciesExactMatch ZFA:0009080 neurectodermal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000134 semapv:crossSpeciesExactMatch ZFA:0009081 mesenchymal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000134 mesenchymal stem cell semapv:crossSpeciesExactMatch FMA:70546 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000135 fibrocyte semapv:crossSpeciesExactMatch FMA:63879 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000136 semapv:crossSpeciesExactMatch ZFA:0009082 fat cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000136 adipocyte semapv:crossSpeciesExactMatch FMA:63880 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000137 semapv:crossSpeciesExactMatch ZFA:0009083 osteocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000137 osteocyte skos:exactMatch VSAO:0000124 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000137 osteocyte semapv:crossSpeciesExactMatch FMA:66779 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000138 semapv:crossSpeciesExactMatch ZFA:0009084 chondrocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000138 chondrocyte semapv:crossSpeciesExactMatch FMA:66782 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000140 semapv:crossSpeciesExactMatch ZFA:0009086 odontocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000141 semapv:crossSpeciesExactMatch ZFA:0009087 cementocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000141 cementocyte semapv:crossSpeciesExactMatch FMA:63003 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000142 hyalocyte semapv:crossSpeciesExactMatch FMA:70620 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000145 semapv:crossSpeciesExactMatch ZFA:0009088 professional antigen presenting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000146 semapv:crossSpeciesExactMatch ZFA:0009089 simple columnar epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000147 semapv:crossSpeciesExactMatch ZFA:0009090 pigment cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000147 pigment cell skos:broadMatch VHOG:0001678 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000148 semapv:crossSpeciesExactMatch ZFA:0009091 melanocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000148 melanocyte skos:broadMatch VHOG:0001679 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000148 melanocyte semapv:crossSpeciesExactMatch FMA:70545 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000150 glandular epithelial cell semapv:crossSpeciesExactMatch FMA:86494 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000151 secretory cell semapv:crossSpeciesExactMatch FMA:86916 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000152 semapv:crossSpeciesExactMatch ZFA:0009092 exocrine cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000152 exocrine cell semapv:crossSpeciesExactMatch FMA:16014 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000153 semapv:crossSpeciesExactMatch ZFA:0009093 GAG secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000155 peptic cell semapv:crossSpeciesExactMatch FMA:62902 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000158 club cell semapv:crossSpeciesExactMatch FMA:14119 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000160 semapv:crossSpeciesExactMatch ZFA:0009094 goblet cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000160 goblet cell semapv:crossSpeciesExactMatch FMA:13148 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000161 semapv:crossSpeciesExactMatch ZFA:0009095 acid secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000162 parietal cell semapv:crossSpeciesExactMatch FMA:62901 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000163 semapv:crossSpeciesExactMatch ZFA:0009096 endocrine cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000163 endocrine cell semapv:crossSpeciesExactMatch FMA:83809 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000164 semapv:crossSpeciesExactMatch ZFA:0009097 enteroendocrine cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000164 enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62930 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000165 semapv:crossSpeciesExactMatch FBbt:00005130 neurosecretory neuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000165 semapv:crossSpeciesExactMatch ZFA:0009098 neuroendocrine cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000165 neuroendocrine cell semapv:crossSpeciesExactMatch FMA:83810 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000166 semapv:crossSpeciesExactMatch ZFA:0009099 chromaffin cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000166 chromaffin cell semapv:crossSpeciesExactMatch FMA:69263 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000167 semapv:crossSpeciesExactMatch ZFA:0009100 peptide hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000168 semapv:crossSpeciesExactMatch ZFA:0009101 insulin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000169 semapv:crossSpeciesExactMatch ZFA:0009102 pancreatic B cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000169 type B pancreatic cell skos:narrowMatch EV:0200009 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000169 type B pancreatic cell semapv:crossSpeciesExactMatch MA:0002419 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000169 type B pancreatic cell semapv:crossSpeciesExactMatch FMA:70586 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000170 semapv:crossSpeciesExactMatch ZFA:0009103 glucagon secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000170 glucagon secreting cell semapv:crossSpeciesExactMatch FMA:84045 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000171 semapv:crossSpeciesExactMatch ZFA:0009104 pancreatic A cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000171 pancreatic A cell semapv:crossSpeciesExactMatch FMA:70585 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000172 semapv:crossSpeciesExactMatch ZFA:0009105 somatostatin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000173 semapv:crossSpeciesExactMatch ZFA:0005743 pancreatic D cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000173 pancreatic D cell semapv:crossSpeciesExactMatch FMA:70587 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000174 semapv:crossSpeciesExactMatch ZFA:0009106 steroid hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000175 luteal cell semapv:crossSpeciesExactMatch FMA:18688 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000177 semapv:crossSpeciesExactMatch ZFA:0009107 testosterone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000178 semapv:crossSpeciesExactMatch ZFA:0009108 Leydig cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000178 Leydig cell semapv:crossSpeciesExactMatch EMAPA:29655 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000178 Leydig cell semapv:crossSpeciesExactMatch FMA:72297 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000179 semapv:crossSpeciesExactMatch ZFA:0009109 progesterone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000180 semapv:crossSpeciesExactMatch ZFA:0009110 estradiol secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000182 semapv:crossSpeciesExactMatch ZFA:0009111 hepatocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000182 hepatocyte semapv:crossSpeciesExactMatch FMA:14515 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000185 semapv:crossSpeciesExactMatch ZFA:0009113 myoepithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000185 myoepithelial cell semapv:crossSpeciesExactMatch FMA:67799 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000187 semapv:crossSpeciesExactMatch FBbt:00005074 muscle cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000187 semapv:crossSpeciesExactMatch ZFA:0009114 muscle cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000187 muscle cell semapv:crossSpeciesExactMatch WBbt:0003675 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000187 muscle cell semapv:crossSpeciesExactMatch FMA:67328 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000188 semapv:crossSpeciesExactMatch ZFA:0009115 skeletal muscle cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000188 cell of skeletal muscle semapv:crossSpeciesExactMatch FMA:9727 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000189 semapv:crossSpeciesExactMatch ZFA:0009116 slow muscle cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000190 semapv:crossSpeciesExactMatch ZFA:0009117 fast muscle cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000192 semapv:crossSpeciesExactMatch ZFA:0009118 smooth muscle cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000192 smooth muscle cell semapv:crossSpeciesExactMatch FMA:14072 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000196 semapv:crossSpeciesExactMatch FBbt:00003360 flight muscle cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000198 semapv:crossSpeciesExactMatch ZFA:0009119 pain receptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000199 semapv:crossSpeciesExactMatch ZFA:0009120 mechanoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000202 semapv:crossSpeciesExactMatch ZFA:0009121 auditory receptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000205 semapv:crossSpeciesExactMatch ZFA:0009123 thermoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000206 semapv:crossSpeciesExactMatch ZFA:0009124 chemoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000207 semapv:crossSpeciesExactMatch ZFA:0009125 olfactory receptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000207 olfactory receptor cell semapv:crossSpeciesExactMatch FMA:67860 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000209 semapv:crossSpeciesExactMatch ZFA:0009126 taste receptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000209 taste receptor cell semapv:crossSpeciesExactMatch FMA:67910 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000210 semapv:crossSpeciesExactMatch FBbt:00004211 photoreceptor cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000210 semapv:crossSpeciesExactMatch ZFA:0009127 photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000210 photoreceptor cell semapv:crossSpeciesExactMatch FMA:86740 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000211 semapv:crossSpeciesExactMatch ZFA:0009128 electrically active cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000212 semapv:crossSpeciesExactMatch ZFA:0009129 absorptive cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000213 semapv:crossSpeciesExactMatch ZFA:0009130 lining cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000214 semapv:crossSpeciesExactMatch ZFA:0009131 synovial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000215 semapv:crossSpeciesExactMatch ZFA:0009132 barrier cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000216 semapv:crossSpeciesExactMatch ZFA:0009133 Sertoli cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000216 Sertoli cell skos:broadMatch VHOG:0001348 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000216 Sertoli cell semapv:crossSpeciesExactMatch FMA:72298 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000217 semapv:crossSpeciesExactMatch ZFA:0009134 insulating cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000218 semapv:crossSpeciesExactMatch ZFA:0009135 myelinating Schwann cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000218 myelinating Schwann cell semapv:crossSpeciesExactMatch FMA:62121 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000219 semapv:crossSpeciesExactMatch ZFA:0009136 motile cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000221 semapv:crossSpeciesExactMatch ZFA:0009137 ectodermal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000221 ectodermal cell semapv:crossSpeciesExactMatch FMA:72549 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000222 semapv:crossSpeciesExactMatch ZFA:0009138 mesodermal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000222 mesodermal cell semapv:crossSpeciesExactMatch FMA:72554 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000223 semapv:crossSpeciesExactMatch ZFA:0009139 endodermal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000223 endodermal cell semapv:crossSpeciesExactMatch FMA:72555 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000225 anucleate cell semapv:crossSpeciesExactMatch FMA:68647 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000232 erythrocyte semapv:crossSpeciesExactMatch FMA:81100 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000233 platelet semapv:crossSpeciesExactMatch FMA:62851 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000234 semapv:crossSpeciesExactMatch ZFA:0009140 phagocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000234 phagocyte semapv:crossSpeciesExactMatch FMA:83806 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000235 semapv:crossSpeciesExactMatch ZFA:0009141 macrophage semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000235 macrophage semapv:crossSpeciesExactMatch FMA:63261 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000235 macrophage semapv:crossSpeciesExactMatch FMA:83585 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000236 semapv:crossSpeciesExactMatch ZFA:0009142 B cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000236 B cell skos:broadMatch VHOG:0001480 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000236 B cell semapv:crossSpeciesExactMatch FMA:62869 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000239 semapv:crossSpeciesExactMatch ZFA:0009143 brush border epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000240 semapv:crossSpeciesExactMatch ZFA:0009144 stratified squamous epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000241 semapv:crossSpeciesExactMatch ZFA:0009145 stratified cuboidal epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000242 semapv:crossSpeciesExactMatch ZFA:0009146 Merkel cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000242 Merkel cell semapv:crossSpeciesExactMatch FMA:70548 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000243 semapv:crossSpeciesExactMatch ZFA:0009147 glial cell (sensu Vertebrata) semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000244 semapv:crossSpeciesExactMatch ZFA:0009148 transitional epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000244 transitional epithelial cell semapv:crossSpeciesExactMatch FMA:66778 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000246 semapv:crossSpeciesExactMatch ZFA:0009149 Mauthner neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000247 semapv:crossSpeciesExactMatch ZFA:0009150 Rohon-Beard neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000247 Rohon-Beard neuron skos:broadMatch VHOG:0001484 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000247 Rohon-Beard neuron semapv:crossSpeciesExactMatch AAO:0010316 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000247 Rohon-Beard neuron semapv:crossSpeciesExactMatch ZFA:0009150 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000249 semapv:crossSpeciesExactMatch ZFA:0009151 hatching gland cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000251 semapv:crossSpeciesExactMatch ZFA:0009152 extramedullary cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000253 semapv:crossSpeciesExactMatch ZFA:0009153 eurydendroid cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000287 semapv:crossSpeciesExactMatch ZFA:0009154 eye photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000293 semapv:crossSpeciesExactMatch ZFA:0005745 structural cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000295 semapv:crossSpeciesExactMatch ZFA:0009155 somatotropin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000300 semapv:crossSpeciesExactMatch FBbt:00005412 gamete semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000300 semapv:crossSpeciesExactMatch ZFA:0009156 gamete semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000300 gamete semapv:crossSpeciesExactMatch FMA:18649 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000301 semapv:crossSpeciesExactMatch FBbt:00000092 primordial germ cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000307 tracheal epithelial cell semapv:crossSpeciesExactMatch FMA:74793 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000311 semapv:crossSpeciesExactMatch ZFA:0009157 keratin accumulating cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000312 semapv:crossSpeciesExactMatch ZFA:0009158 keratinocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000312 keratinocyte semapv:crossSpeciesExactMatch FMA:62879 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000313 serous secreting cell semapv:crossSpeciesExactMatch FMA:62511 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000319 semapv:crossSpeciesExactMatch ZFA:0009159 mucus secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000321 semapv:crossSpeciesExactMatch ZFA:0009160 seminal fluid secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000322 pulmonary alveolar epithelial cell semapv:crossSpeciesExactMatch FMA:62499 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000327 semapv:crossSpeciesExactMatch ZFA:0009162 extracellular matrix secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000328 semapv:crossSpeciesExactMatch ZFA:0009163 myelin accumulating cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000329 semapv:crossSpeciesExactMatch ZFA:0009164 oxygen accumulating cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000333 semapv:crossSpeciesExactMatch ZFA:0007086 migratory neural crest cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000333 migratory neural crest cell semapv:crossSpeciesExactMatch FMA:86667 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000335 semapv:crossSpeciesExactMatch ZFA:0009166 mesenchyme condensation cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000336 semapv:crossSpeciesExactMatch ZFA:0009167 adrenal medulla cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000336 adrenal medulla chromaffin cell semapv:crossSpeciesExactMatch FMA:69262 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000337 semapv:crossSpeciesExactMatch ZFA:0009168 neuroblast (sensu Vertebrata) semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000338 semapv:crossSpeciesExactMatch FBbt:00005146 neuroblast semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000339 semapv:crossSpeciesExactMatch ZFA:0009169 glioblast (sensu Vertebrata) semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000339 glioblast (sensu Vertebrata) semapv:crossSpeciesExactMatch FMA:70564 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000340 semapv:crossSpeciesExactMatch FBbt:00005145 glioblast semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000342 semapv:crossSpeciesExactMatch ZFA:0009170 pigment cell (sensu Vertebrata) semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000343 semapv:crossSpeciesExactMatch ZFA:0009171 visual pigment cell (sensu Vertebrata) semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000343 visual pigment cell (sensu Vertebrata) semapv:crossSpeciesExactMatch FMA:63846 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000345 semapv:crossSpeciesExactMatch ZFA:0009173 dental papilla cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000347 semapv:crossSpeciesExactMatch ZFA:0009174 scleral cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000348 semapv:crossSpeciesExactMatch ZFA:0009175 choroidal cell of the eye semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000349 semapv:crossSpeciesExactMatch ZFA:0009176 extraembryonic cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000351 trophoblast cell semapv:crossSpeciesExactMatch FMA:83028 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000353 semapv:crossSpeciesExactMatch ZFA:0009177 blastoderm cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000353 blastoderm cell semapv:crossSpeciesExactMatch FMA:72551 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000354 semapv:crossSpeciesExactMatch ZFA:0009178 blastemal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000355 semapv:crossSpeciesExactMatch ZFA:0009179 muscle stem cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000355 multi-potent skeletal muscle stem cell semapv:crossSpeciesExactMatch FMA:86767 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000357 semapv:crossSpeciesExactMatch ZFA:0009180 stratified epithelial stem cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000359 semapv:crossSpeciesExactMatch ZFA:0009181 vascular associated smooth muscle cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000361 semapv:crossSpeciesExactMatch ZFA:0009182 gastrula cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000362 semapv:crossSpeciesExactMatch ZFA:0009183 epidermal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000362 epidermal cell semapv:crossSpeciesExactMatch FMA:62411 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000365 animal zygote semapv:crossSpeciesExactMatch EHDAA2:0004546 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000365 animal zygote semapv:crossSpeciesExactMatch FMA:72395 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000372 semapv:crossSpeciesExactMatch FBbt:00005171 tormogen cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000373 semapv:crossSpeciesExactMatch FBbt:00001789 histoblast semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000374 semapv:crossSpeciesExactMatch FBbt:00005169 trichogen cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000375 semapv:crossSpeciesExactMatch ZFA:0009184 osteoprogenitor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000379 semapv:crossSpeciesExactMatch ZFA:0009185 sensory processing neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000380 semapv:crossSpeciesExactMatch FBbt:00005173 thecogen cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000381 semapv:crossSpeciesExactMatch ZFA:0009186 neurosecretory neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000382 semapv:crossSpeciesExactMatch FBbt:00005219 scolopale cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000383 semapv:crossSpeciesExactMatch ZFA:0009187 nephrogenic mesenchyme stem cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000384 semapv:crossSpeciesExactMatch ZFA:0009188 ligament cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000385 semapv:crossSpeciesExactMatch FBbt:00005062 prohemocyte semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000387 semapv:crossSpeciesExactMatch FBbt:00005063 hemocyte semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000388 semapv:crossSpeciesExactMatch ZFA:0009189 tendon cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000393 semapv:crossSpeciesExactMatch ZFA:0009190 electrically responsive cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000394 semapv:crossSpeciesExactMatch FBbt:00001685 embryonic/larval plasmatocyte semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000395 semapv:crossSpeciesExactMatch FBbt:00001689 procrystal cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000396 semapv:crossSpeciesExactMatch FBbt:00001687 lamellocyte semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000398 semapv:crossSpeciesExactMatch FBbt:00001691 polygonal cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000402 semapv:crossSpeciesExactMatch ZFA:0009191 CNS interneuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000404 semapv:crossSpeciesExactMatch ZFA:0009193 electrically signaling cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000406 semapv:crossSpeciesExactMatch ZFA:0009194 CNS short range interneuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000407 semapv:crossSpeciesExactMatch FBbt:00005221 scolopidial ligament cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000410 semapv:crossSpeciesExactMatch ZFA:0009195 CNS long range interneuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000411 semapv:crossSpeciesExactMatch ZFA:0009196 hypodermal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000411 Caenorhabditis hypodermal cell semapv:crossSpeciesExactMatch WBbt:0007846 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000415 diploid cell semapv:crossSpeciesExactMatch FMA:72300 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000418 arcade cell semapv:crossSpeciesExactMatch WBbt:0005793 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000421 coelomocyte semapv:crossSpeciesExactMatch WBbt:0005751 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000424 excretory cell semapv:crossSpeciesExactMatch WBbt:0005812 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000428 semapv:crossSpeciesExactMatch ZFA:0000084 yolk semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000429 semapv:crossSpeciesExactMatch FBbt:00007108 imaginal disc epithelial cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000430 semapv:crossSpeciesExactMatch ZFA:0009198 xanthophore semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000431 semapv:crossSpeciesExactMatch ZFA:0009199 iridophore semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000432 semapv:crossSpeciesExactMatch ZFA:0009200 reticular cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000432 reticular cell semapv:crossSpeciesExactMatch FMA:62877 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000435 semapv:crossSpeciesExactMatch ZFA:0009201 alkali secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000437 semapv:crossSpeciesExactMatch ZFA:0009202 follicle stimulating hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000437 gonadtroph semapv:crossSpeciesExactMatch FMA:83100 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000438 semapv:crossSpeciesExactMatch ZFA:0009203 luteinizing hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000439 semapv:crossSpeciesExactMatch ZFA:0009204 prolactin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000440 semapv:crossSpeciesExactMatch ZFA:0009205 melanocyte stimulating hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000441 semapv:crossSpeciesExactMatch FBbt:00004903 follicle stem cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000442 follicular dendritic cell semapv:crossSpeciesExactMatch FMA:83037 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000443 semapv:crossSpeciesExactMatch ZFA:0009206 calcitonin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000446 chief cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69078 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000448 white adipocyte semapv:crossSpeciesExactMatch FMA:83434 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000449 brown adipocyte semapv:crossSpeciesExactMatch FMA:83435 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000450 semapv:crossSpeciesExactMatch ZFA:0009082 fat cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000451 semapv:crossSpeciesExactMatch ZFA:0009209 dendritic cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000451 dendritic cell semapv:crossSpeciesExactMatch FMA:83036 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000452 semapv:crossSpeciesExactMatch ZFA:0009210 thyroid hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000453 Langerhans cell semapv:crossSpeciesExactMatch FMA:63072 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000454 semapv:crossSpeciesExactMatch ZFA:0009211 epinephrin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000457 semapv:crossSpeciesExactMatch ZFA:0009212 biogenic amine secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000458 semapv:crossSpeciesExactMatch ZFA:0009213 serotonin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000459 semapv:crossSpeciesExactMatch ZFA:0009214 norepinephrine secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000460 semapv:crossSpeciesExactMatch ZFA:0009215 glucocorticoid secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000462 semapv:crossSpeciesExactMatch FBbt:00003219 adepithelial cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000463 semapv:crossSpeciesExactMatch FBbt:00007325 epidermal cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000464 semapv:crossSpeciesExactMatch FBbt:00004994 epidermoblast semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000465 semapv:crossSpeciesExactMatch FBbt:00001666 cardioblast semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000467 semapv:crossSpeciesExactMatch ZFA:0009216 adrenocorticotropic hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000468 semapv:crossSpeciesExactMatch FBbt:00005147 neuroglioblast semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000469 semapv:crossSpeciesExactMatch FBbt:00005149 ganglion mother cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000470 semapv:crossSpeciesExactMatch ZFA:0009217 digestive enzyme secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000474 semapv:crossSpeciesExactMatch FBbt:00005058 pericardial cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000476 semapv:crossSpeciesExactMatch ZFA:0009218 thyroid stimulating hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000476 thyrotroph semapv:crossSpeciesExactMatch FMA:83099 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000477 semapv:crossSpeciesExactMatch FBbt:00004904 follicle cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000482 semapv:crossSpeciesExactMatch FBbt:00058020 juvenile hormone secreting cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000486 semapv:crossSpeciesExactMatch FBbt:00005059 garland cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000487 semapv:crossSpeciesExactMatch FBbt:00004995 oenocyte semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000488 semapv:crossSpeciesExactMatch ZFA:0009219 visible light photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000490 semapv:crossSpeciesExactMatch ZFA:0009220 photopic photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000492 CD4-positive helper T cell semapv:crossSpeciesExactMatch FMA:70572 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000494 semapv:crossSpeciesExactMatch ZFA:0009221 UV sensitive photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000495 semapv:crossSpeciesExactMatch ZFA:0009222 blue sensitive photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000496 semapv:crossSpeciesExactMatch ZFA:0009223 green sensitive photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000497 semapv:crossSpeciesExactMatch ZFA:0009224 red sensitive photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000498 semapv:crossSpeciesExactMatch ZFA:0009225 inhibitory interneuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000498 inhibitory interneuron semapv:crossSpeciesExactMatch FMA:84776 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000499 semapv:crossSpeciesExactMatch ZFA:0009226 stromal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000499 stromal cell semapv:crossSpeciesExactMatch FMA:83624 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000501 semapv:crossSpeciesExactMatch ZFA:0009227 granulosa cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000501 granulosa cell semapv:crossSpeciesExactMatch FMA:18718 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000502 semapv:crossSpeciesExactMatch ZFA:0009228 D cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000502 type D enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62935 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000503 semapv:crossSpeciesExactMatch ZFA:0009229 theca cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000505 semapv:crossSpeciesExactMatch ZFA:0009230 substance P secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000506 semapv:crossSpeciesExactMatch ZFA:0009231 enkephalin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000507 semapv:crossSpeciesExactMatch ZFA:0009232 endorphin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000508 type G enteroendocrine cell semapv:crossSpeciesExactMatch FMA:67609 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000510 paneth cell semapv:crossSpeciesExactMatch FMA:62897 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000512 semapv:crossSpeciesExactMatch ZFA:0009233 paracrine cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000513 semapv:crossSpeciesExactMatch ZFA:0009234 cardiac muscle myoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000513 cardiac muscle myoblast semapv:crossSpeciesExactMatch FMA:84797 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000514 semapv:crossSpeciesExactMatch ZFA:0009235 smooth muscle myoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000514 smooth muscle myoblast semapv:crossSpeciesExactMatch FMA:84798 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000515 semapv:crossSpeciesExactMatch ZFA:0009236 skeletal muscle myoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000515 skeletal muscle myoblast semapv:crossSpeciesExactMatch FMA:84799 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000516 semapv:crossSpeciesExactMatch ZFA:0009237 perineuronal satellite cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000516 perineuronal satellite cell semapv:crossSpeciesExactMatch FMA:54550 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000523 mononuclear cytotrophoblast cell semapv:crossSpeciesExactMatch FMA:83042 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000525 syncytiotrophoblast cell semapv:crossSpeciesExactMatch FMA:83043 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000526 semapv:crossSpeciesExactMatch ZFA:0009238 afferent neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000526 afferent neuron semapv:crossSpeciesExactMatch FMA:87653 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000527 semapv:crossSpeciesExactMatch ZFA:0009239 efferent neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000528 semapv:crossSpeciesExactMatch ZFA:0009240 nitrergic neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000528 nitrergic neuron semapv:crossSpeciesExactMatch FMA:84792 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000529 semapv:crossSpeciesExactMatch ZFA:0009241 pigmented epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000530 semapv:crossSpeciesExactMatch ZFA:0009242 primary neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000532 semapv:crossSpeciesExactMatch ZFA:0009243 CaP motoneuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000533 semapv:crossSpeciesExactMatch ZFA:0009244 primary motor neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000534 semapv:crossSpeciesExactMatch ZFA:0009245 primary interneuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000535 semapv:crossSpeciesExactMatch ZFA:0009246 secondary neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000536 semapv:crossSpeciesExactMatch ZFA:0009247 secondary motor neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000540 semapv:crossSpeciesExactMatch FBbt:00005106 neuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000540 semapv:crossSpeciesExactMatch ZFA:0009248 neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000540 neuron skos:broadMatch VHOG:0001483 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000540 neuron semapv:crossSpeciesExactMatch WBbt:0003679 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000540 neuron semapv:crossSpeciesExactMatch FMA:54527 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000541 semapv:crossSpeciesExactMatch ZFA:0009249 melanoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000541 melanoblast semapv:crossSpeciesExactMatch FMA:83377 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000542 semapv:crossSpeciesExactMatch ZFA:0009250 lymphocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000542 lymphocyte skos:broadMatch VHOG:0001535 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000542 lymphocyte semapv:crossSpeciesExactMatch FMA:62863 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000545 T-helper 1 cell semapv:crossSpeciesExactMatch FMA:84382 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000546 T-helper 2 cell semapv:crossSpeciesExactMatch FMA:84385 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000547 proerythroblast semapv:crossSpeciesExactMatch FMA:83518 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000549 semapv:crossSpeciesExactMatch ZFA:0005236 basophilic erythroblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000549 basophilic erythroblast semapv:crossSpeciesExactMatch FMA:83505 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000550 semapv:crossSpeciesExactMatch ZFA:0005241 polychromatophilic erythroblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000550 polychromatophilic erythroblast semapv:crossSpeciesExactMatch FMA:83506 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000552 orthochromatic erythroblast semapv:crossSpeciesExactMatch FMA:84646 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000553 megakaryocyte progenitor cell semapv:crossSpeciesExactMatch FMA:84235 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000556 megakaryocyte semapv:crossSpeciesExactMatch FMA:83555 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000557 semapv:crossSpeciesExactMatch ZFA:0009251 granulocyte monocyte progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000558 semapv:crossSpeciesExactMatch ZFA:0009252 reticulocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000559 semapv:crossSpeciesExactMatch ZFA:0009253 promonocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000559 promonocyte semapv:crossSpeciesExactMatch FMA:83551 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000560 semapv:crossSpeciesExactMatch ZFA:0009254 band form neutrophil semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000561 semapv:crossSpeciesExactMatch ZFA:0009255 amacrine cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000561 amacrine cell semapv:crossSpeciesExactMatch FMA:67766 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000562 semapv:crossSpeciesExactMatch ZFA:0009256 nucleate erythrocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000564 semapv:crossSpeciesExactMatch ZFA:0009257 neutrophilic promyelocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000564 neutrophilic promyelocyte semapv:crossSpeciesExactMatch FMA:84196 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000566 semapv:crossSpeciesExactMatch ZFA:0009258 angioblastic mesenchymal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000568 amine precursor uptake and decarboxylation cell semapv:crossSpeciesExactMatch FMA:83114 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000569 semapv:crossSpeciesExactMatch ZFA:0009259 cardiac mesenchymal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000570 semapv:crossSpeciesExactMatch ZFA:0009260 parafollicular cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000570 parafollicular cell skos:narrowMatch SCTID:176770005 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000570 parafollicular cell semapv:crossSpeciesExactMatch FMA:68653 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000571 semapv:crossSpeciesExactMatch ZFA:0009261 leucophore semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000573 semapv:crossSpeciesExactMatch ZFA:0009262 retinal cone cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000573 retinal cone cell semapv:crossSpeciesExactMatch FMA:67748 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000574 semapv:crossSpeciesExactMatch ZFA:0009263 erythrophore semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000575 semapv:crossSpeciesExactMatch ZFA:0009264 corneal epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000575 corneal epithelial cell semapv:crossSpeciesExactMatch FMA:70551 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000576 semapv:crossSpeciesExactMatch ZFA:0009265 monocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000576 monocyte semapv:crossSpeciesExactMatch FMA:62864 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000577 type EC enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62934 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000577 type EC enteroendocrine cell semapv:crossSpeciesExactMatch FMA:83132 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000579 semapv:crossSpeciesExactMatch FBbt:00004905 border follicle cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000580 semapv:crossSpeciesExactMatch ZFA:0009266 neutrophilic myelocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000580 neutrophilic myelocyte semapv:crossSpeciesExactMatch FMA:83540 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000581 semapv:crossSpeciesExactMatch ZFA:0009267 peritoneal macrophage semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000581 peritoneal macrophage semapv:crossSpeciesExactMatch FMA:83025 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000582 semapv:crossSpeciesExactMatch ZFA:0009268 neutrophilic metamyelocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000582 neutrophilic metamyelocyte semapv:crossSpeciesExactMatch FMA:84197 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000583 alveolar macrophage semapv:crossSpeciesExactMatch FMA:83023 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000584 semapv:crossSpeciesExactMatch ZFA:0009269 enterocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000584 enterocyte semapv:crossSpeciesExactMatch FMA:62122 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000586 germ cell skos:broadMatch VHOG:0001534 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000586 germ cell skos:narrowMatch NCIT:C12597 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000586 germ cell semapv:crossSpeciesExactMatch WBbt:0006796 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000588 semapv:crossSpeciesExactMatch ZFA:0009270 odontoclast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000588 odontoclast semapv:crossSpeciesExactMatch FMA:83027 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000589 cochlear inner hair cell semapv:crossSpeciesExactMatch FMA:62365 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000590 small luteal cell semapv:crossSpeciesExactMatch FMA:18690 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000592 large luteal cell semapv:crossSpeciesExactMatch FMA:18689 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000593 semapv:crossSpeciesExactMatch ZFA:0009271 androgen secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000594 semapv:crossSpeciesExactMatch ZFA:0009272 skeletal muscle satellite cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000598 semapv:crossSpeciesExactMatch ZFA:0009273 pyramidal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000598 pyramidal neuron semapv:crossSpeciesExactMatch FMA:67310 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000598 pyramidal neuron semapv:crossSpeciesExactMatch FMA:86775 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000601 cochlear outer hair cell semapv:crossSpeciesExactMatch FMA:62366 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000602 semapv:crossSpeciesExactMatch ZFA:0009274 pressoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000604 semapv:crossSpeciesExactMatch ZFA:0009275 retinal rod cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000604 retinal rod cell semapv:crossSpeciesExactMatch FMA:67747 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000609 vestibular hair cell semapv:crossSpeciesExactMatch FMA:62351 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000612 eosinophilic myelocyte semapv:crossSpeciesExactMatch FMA:83542 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000614 basophilic myelocyte semapv:crossSpeciesExactMatch FMA:83543 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000617 semapv:crossSpeciesExactMatch FBbt:00007228 GABAergic neuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000617 semapv:crossSpeciesExactMatch ZFA:0009276 GABAergic neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000617 GABAergic neuron semapv:crossSpeciesExactMatch WBbt:0005190 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000617 GABAergic neuron semapv:crossSpeciesExactMatch FMA:84788 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000622 semapv:crossSpeciesExactMatch ZFA:0009277 acinar cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000622 acinar cell semapv:crossSpeciesExactMatch FMA:83625 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000623 semapv:crossSpeciesExactMatch ZFA:0009278 natural killer cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000623 natural killer cell skos:broadMatch VHOG:0001697 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000623 natural killer cell semapv:crossSpeciesExactMatch FMA:63147 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000623 natural killer cell semapv:crossSpeciesExactMatch FMA:83601 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000626 semapv:crossSpeciesExactMatch ZFA:0001694 olfactory granule cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000630 semapv:crossSpeciesExactMatch ZFA:0009387 supportive cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000632 semapv:crossSpeciesExactMatch ZFA:0009279 ito cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000632 hepatic stellate cell semapv:crossSpeciesExactMatch FMA:67763 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000633 Hensen cell semapv:crossSpeciesExactMatch FMA:79799 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000634 Claudius cell semapv:crossSpeciesExactMatch FMA:79802 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000635 Deiter's cell semapv:crossSpeciesExactMatch FMA:75725 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000636 semapv:crossSpeciesExactMatch ZFA:0009280 Muller cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000637 chromophil cell of anterior pituitary gland semapv:crossSpeciesExactMatch FMA:83089 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000638 acidophil cell of pars distalis of adenohypophysis semapv:crossSpeciesExactMatch FMA:83093 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000639 basophil cell of pars distalis of adenohypophysis semapv:crossSpeciesExactMatch FMA:83094 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000641 chromophobe cell semapv:crossSpeciesExactMatch FMA:83626 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000642 semapv:crossSpeciesExactMatch ZFA:0009281 folliculostellate cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000644 semapv:crossSpeciesExactMatch ZFA:0009282 Bergmann glial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000644 Bergmann glial cell semapv:crossSpeciesExactMatch FMA:54559 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000645 pituicyte semapv:crossSpeciesExactMatch FMA:83503 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000646 basal cell semapv:crossSpeciesExactMatch FMA:62516 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000647 multinucleated giant cell semapv:crossSpeciesExactMatch FMA:83035 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000648 semapv:crossSpeciesExactMatch ZFA:0005238 juxtaglomerular cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000648 kidney granular cell semapv:crossSpeciesExactMatch FMA:84138 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000649 prickle cell semapv:crossSpeciesExactMatch FMA:69059 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000650 semapv:crossSpeciesExactMatch ZFA:0009283 mesangial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000650 mesangial cell semapv:crossSpeciesExactMatch FMA:70972 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000652 semapv:crossSpeciesExactMatch ZFA:0009284 pinealocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000652 pinealocyte semapv:crossSpeciesExactMatch FMA:83417 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000653 semapv:crossSpeciesExactMatch ZFA:0009285 podocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000653 podocyte semapv:crossSpeciesExactMatch FMA:70967 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000654 primary oocyte semapv:crossSpeciesExactMatch FMA:18645 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000655 secondary oocyte semapv:crossSpeciesExactMatch FMA:18646 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000656 primary spermatocyte semapv:crossSpeciesExactMatch FMA:72292 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000657 semapv:crossSpeciesExactMatch FBbt:00004941 secondary spermatocyte semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000657 secondary spermatocyte semapv:crossSpeciesExactMatch FMA:72293 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000666 semapv:crossSpeciesExactMatch ZFA:0009286 fenestrated cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000667 semapv:crossSpeciesExactMatch ZFA:0009287 collagen secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000669 semapv:crossSpeciesExactMatch ZFA:0009112 pericyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000669 pericyte semapv:crossSpeciesExactMatch FMA:63174 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000670 semapv:crossSpeciesExactMatch ZFA:0009288 primordial germ cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000670 primordial germ cell semapv:crossSpeciesExactMatch FMA:70567 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000671 semapv:crossSpeciesExactMatch FBbt:00004906 centripetal follicle cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000673 semapv:crossSpeciesExactMatch FBbt:00003686 Kenyon cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000674 semapv:crossSpeciesExactMatch FBbt:00004910 stalk follicle cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000677 semapv:crossSpeciesExactMatch ZFA:0009289 gut absorptive cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000679 semapv:crossSpeciesExactMatch FBbt:00100291 glutamatergic neuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000679 semapv:crossSpeciesExactMatch ZFA:0009290 glutamatergic neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000679 glutamatergic neuron semapv:crossSpeciesExactMatch WBbt:0006829 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000680 semapv:crossSpeciesExactMatch ZFA:0009291 muscle precursor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000681 semapv:crossSpeciesExactMatch ZFA:0009292 radial glial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000682 semapv:crossSpeciesExactMatch ZFA:0009293 M cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000682 M cell of gut semapv:crossSpeciesExactMatch FMA:62929 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000683 semapv:crossSpeciesExactMatch ZFA:0009294 ependymoglial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000686 semapv:crossSpeciesExactMatch ZFA:0009295 cerebrospinal fluid secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000687 semapv:crossSpeciesExactMatch FBbt:00004213 photoreceptor cell R1 semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000688 semapv:crossSpeciesExactMatch ZFA:0009296 perijunctional fibroblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000690 semapv:crossSpeciesExactMatch FBbt:00004215 photoreceptor cell R2 semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000691 semapv:crossSpeciesExactMatch ZFA:0009297 stellate interneuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000692 semapv:crossSpeciesExactMatch ZFA:0009298 terminal Schwann cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000693 semapv:crossSpeciesExactMatch ZFA:0009299 neuroglioform cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000694 semapv:crossSpeciesExactMatch FBbt:00004217 photoreceptor cell R3 semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000695 semapv:crossSpeciesExactMatch ZFA:0009300 Cajal-Retzius cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000696 PP cell semapv:crossSpeciesExactMatch FMA:62938 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000696 PP cell semapv:crossSpeciesExactMatch FMA:83409 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000697 semapv:crossSpeciesExactMatch FBbt:00004219 photoreceptor cell R4 semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000700 semapv:crossSpeciesExactMatch FBbt:00005131 dopaminergic neuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000700 semapv:crossSpeciesExactMatch ZFA:0009301 dopaminergic neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000700 dopaminergic neuron semapv:crossSpeciesExactMatch WBbt:0006746 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000700 dopaminergic neuron semapv:crossSpeciesExactMatch FMA:84787 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000702 semapv:crossSpeciesExactMatch FBbt:00004221 photoreceptor cell R5 semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000703 semapv:crossSpeciesExactMatch ZFA:0009302 sustentacular cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000704 semapv:crossSpeciesExactMatch ZFA:0009303 endothelial tip cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000705 semapv:crossSpeciesExactMatch FBbt:00004223 photoreceptor cell R6 semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000706 semapv:crossSpeciesExactMatch ZFA:0009304 choroid plexus epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000706 choroid plexus epithelial cell semapv:crossSpeciesExactMatch FMA:70549 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000707 semapv:crossSpeciesExactMatch FBbt:00004225 photoreceptor cell R7 semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000708 semapv:crossSpeciesExactMatch ZFA:0009305 leptomeningeal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000709 semapv:crossSpeciesExactMatch FBbt:00004227 photoreceptor cell R8 semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000710 neurecto-epithelial cell semapv:crossSpeciesExactMatch FMA:70557 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000715 semapv:crossSpeciesExactMatch FBbt:00001690 embryonic/larval crystal cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000718 semapv:crossSpeciesExactMatch FBbt:00004193 cone cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000723 semapv:crossSpeciesExactMatch ZFA:0009307 somatic stem cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000731 semapv:crossSpeciesExactMatch ZFA:0009308 urothelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000731 urothelial cell semapv:crossSpeciesExactMatch FMA:84127 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000735 semapv:crossSpeciesExactMatch FBbt:00005917 lymph gland derived hemocyte semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000737 semapv:crossSpeciesExactMatch ZFA:0005784 striated muscle cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000737 striated muscle cell semapv:crossSpeciesExactMatch FMA:86936 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000738 semapv:crossSpeciesExactMatch ZFA:0009309 leukocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000738 leukocyte skos:narrowMatch NCIT:C12529 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000738 leukocyte semapv:crossSpeciesExactMatch FMA:62852 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000740 semapv:crossSpeciesExactMatch ZFA:0009310 retinal ganglion cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000740 retinal ganglion cell semapv:crossSpeciesExactMatch FMA:67765 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000741 semapv:crossSpeciesExactMatch ZFA:0009311 spinal accessory motor neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000742 semapv:crossSpeciesExactMatch ZFA:0009312 periarticular chondrocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000743 semapv:crossSpeciesExactMatch ZFA:0009313 hypertrophic chondrocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000744 semapv:crossSpeciesExactMatch ZFA:0009314 columnar chondrocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000745 semapv:crossSpeciesExactMatch ZFA:0009315 horizontal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000746 semapv:crossSpeciesExactMatch ZFA:0009316 cardiac muscle cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000746 cardiac muscle cell semapv:crossSpeciesExactMatch FMA:14067 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000747 semapv:crossSpeciesExactMatch ZFA:0009317 cyanophore semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000748 semapv:crossSpeciesExactMatch ZFA:0009318 retinal bipolar neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000749 semapv:crossSpeciesExactMatch ZFA:0009319 ON-bipolar cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000750 semapv:crossSpeciesExactMatch ZFA:0009320 OFF-bipolar cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000751 semapv:crossSpeciesExactMatch ZFA:0009321 rod bipolar cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000751 rod bipolar cell semapv:crossSpeciesExactMatch FMA:67750 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000752 semapv:crossSpeciesExactMatch ZFA:0009322 cone retinal bipolar cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000762 semapv:crossSpeciesExactMatch ZFA:0009323 thrombocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000763 semapv:crossSpeciesExactMatch ZFA:0009324 myeloid cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000764 semapv:crossSpeciesExactMatch ZFA:0009325 erythroid lineage cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000764 erythroid lineage cell semapv:crossSpeciesExactMatch FMA:62845 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000764 erythroid lineage cell semapv:crossSpeciesExactMatch FMA:83516 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000765 semapv:crossSpeciesExactMatch ZFA:0005237 erythroblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000765 erythroblast semapv:crossSpeciesExactMatch FMA:83504 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000766 semapv:crossSpeciesExactMatch ZFA:0009326 myeloid leukocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000767 basophil semapv:crossSpeciesExactMatch FMA:62862 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000769 basophilic metamyelocyte semapv:crossSpeciesExactMatch FMA:84198 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000771 eosinophil semapv:crossSpeciesExactMatch FMA:62861 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000775 semapv:crossSpeciesExactMatch ZFA:0009327 neutrophil semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000775 neutrophil semapv:crossSpeciesExactMatch FMA:62860 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000776 semapv:crossSpeciesExactMatch ZFA:0009328 immature neutrophil semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000778 semapv:crossSpeciesExactMatch ZFA:0009329 mononuclear osteoclast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000781 semapv:crossSpeciesExactMatch ZFA:0009330 mononuclear odontoclast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000785 semapv:crossSpeciesExactMatch ZFA:0009331 mature B cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000786 semapv:crossSpeciesExactMatch ZFA:0009332 plasma cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000786 plasma cell semapv:crossSpeciesExactMatch FMA:70574 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000787 semapv:crossSpeciesExactMatch ZFA:0009333 memory B cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000788 semapv:crossSpeciesExactMatch ZFA:0009334 naive B cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000789 semapv:crossSpeciesExactMatch ZFA:0009335 alpha-beta T cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000798 semapv:crossSpeciesExactMatch ZFA:0009336 gamma-delta T cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000799 semapv:crossSpeciesExactMatch ZFA:0009337 immature gamma-delta T cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000800 semapv:crossSpeciesExactMatch ZFA:0009338 mature gamma-delta T cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000801 semapv:crossSpeciesExactMatch ZFA:0009339 gamma-delta intraepithelial T cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000813 semapv:crossSpeciesExactMatch ZFA:0009342 memory T cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000815 regulatory T cell semapv:crossSpeciesExactMatch FMA:84070 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000816 semapv:crossSpeciesExactMatch ZFA:0009343 immature B cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000817 semapv:crossSpeciesExactMatch ZFA:0009344 precursor B cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000818 semapv:crossSpeciesExactMatch ZFA:0009345 transitional stage B cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000823 semapv:crossSpeciesExactMatch ZFA:0009346 immature natural killer cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000824 semapv:crossSpeciesExactMatch ZFA:0009347 mature natural killer cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000825 semapv:crossSpeciesExactMatch ZFA:0009348 pro-NK cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000826 semapv:crossSpeciesExactMatch ZFA:0009349 pro-B cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000827 semapv:crossSpeciesExactMatch ZFA:0009350 pro-T cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000828 semapv:crossSpeciesExactMatch ZFA:0009351 thromboblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000830 basophilic promyelocyte semapv:crossSpeciesExactMatch FMA:84208 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000833 eosinophilic promyelocyte semapv:crossSpeciesExactMatch FMA:84199 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000834 semapv:crossSpeciesExactMatch ZFA:0009352 neutrophil progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000835 semapv:crossSpeciesExactMatch ZFA:0009353 myeloblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000835 myeloblast semapv:crossSpeciesExactMatch FMA:83524 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000836 promyelocyte semapv:crossSpeciesExactMatch FMA:83530 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000837 semapv:crossSpeciesExactMatch ZFA:0009354 hematopoietic multipotent progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000838 semapv:crossSpeciesExactMatch ZFA:0009355 lymphoid progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000838 lymphoid lineage restricted progenitor cell semapv:crossSpeciesExactMatch FMA:70338 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000839 semapv:crossSpeciesExactMatch ZFA:0009356 myeloid lineage restricted progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000839 myeloid lineage restricted progenitor cell semapv:crossSpeciesExactMatch FMA:70339 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000841 mature conventional dendritic cell semapv:crossSpeciesExactMatch FMA:83038 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000842 semapv:crossSpeciesExactMatch ZFA:0009357 mononuclear cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000842 mononuclear cell semapv:crossSpeciesExactMatch FMA:86713 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000847 semapv:crossSpeciesExactMatch ZFA:0009358 ciliated olfactory receptor neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000848 semapv:crossSpeciesExactMatch ZFA:0009359 microvillous olfactory receptor neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000849 semapv:crossSpeciesExactMatch ZFA:0009360 crypt olfactory receptor neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000850 semapv:crossSpeciesExactMatch FBbt:00005133 serotonergic neuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0000850 semapv:crossSpeciesExactMatch ZFA:0009361 serotonergic neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000850 serotonergic neuron semapv:crossSpeciesExactMatch WBbt:0006837 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000851 semapv:crossSpeciesExactMatch ZFA:0009362 neuromast mantle cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000852 semapv:crossSpeciesExactMatch ZFA:0009363 neuromast support cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000853 semapv:crossSpeciesExactMatch ZFA:0009364 olfactory epithelial support cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000853 olfactory epithelial supporting cell semapv:crossSpeciesExactMatch FMA:62302 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000854 semapv:crossSpeciesExactMatch ZFA:0009365 interneuromast cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000855 semapv:crossSpeciesExactMatch ZFA:0009366 hair cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000856 semapv:crossSpeciesExactMatch ZFA:0009367 neuromast hair cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000857 semapv:crossSpeciesExactMatch ZFA:0009368 slow muscle myoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000858 semapv:crossSpeciesExactMatch ZFA:0009369 fast muscle myoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000861 elicited macrophage semapv:crossSpeciesExactMatch FMA:84643 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000861 elicited macrophage semapv:crossSpeciesExactMatch FMA:84645 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000864 tissue-resident macrophage semapv:crossSpeciesExactMatch FMA:84642 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000864 tissue-resident macrophage semapv:crossSpeciesExactMatch FMA:84644 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000871 splenic macrophage semapv:crossSpeciesExactMatch FMA:83026 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000891 foam cell semapv:crossSpeciesExactMatch FMA:83586 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000893 thymocyte semapv:crossSpeciesExactMatch XAO:0003159 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000893 thymocyte semapv:crossSpeciesExactMatch FMA:72202 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000910 cytotoxic T cell semapv:crossSpeciesExactMatch FMA:70573 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000917 Tc1 cell semapv:crossSpeciesExactMatch FMA:84793 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000918 Tc2 cell semapv:crossSpeciesExactMatch FMA:84794 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000980 plasmablast semapv:crossSpeciesExactMatch FMA:84371 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000988 semapv:crossSpeciesExactMatch ZFA:0005830 hematopoietic cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0000988 hematopoietic cell semapv:crossSpeciesExactMatch FMA:70366 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000988 hematopoietic cell semapv:crossSpeciesExactMatch FMA:83598 semapv:UnspecifiedMatching obo:cl.owl
-CL:0000990 conventional dendritic cell semapv:crossSpeciesExactMatch FMA:84191 semapv:UnspecifiedMatching obo:cl.owl
-CL:0001031 semapv:crossSpeciesExactMatch ZFA:0001691 cerebellar granule cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0001039 terminally differentiated osteoblast skos:exactMatch VSAO:0000116 semapv:UnspecifiedMatching obo:cl.owl
-CL:0001040 non-terminally differentiated osteoblast skos:exactMatch VSAO:0000117 semapv:UnspecifiedMatching obo:cl.owl
-CL:0001658 semapv:crossSpeciesExactMatch FBbt:00004230 pigment cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0002003 CD34-positive, GlyA-negative erythroid progenitor cell semapv:crossSpeciesExactMatch FMA:83517 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002062 pulmonary alveolar type 1 cell semapv:crossSpeciesExactMatch FMA:62500 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002063 pulmonary alveolar type 2 cell semapv:crossSpeciesExactMatch FMA:62501 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002064 semapv:crossSpeciesExactMatch ZFA:0005739 pancreatic acinar cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002064 pancreatic acinar cell semapv:crossSpeciesExactMatch FMA:63032 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002066 Feyrter cell semapv:crossSpeciesExactMatch FMA:14118 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002067 type A enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62939 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002068 Purkinje myocyte semapv:crossSpeciesExactMatch FMA:14146 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002069 type II vestibular sensory cell semapv:crossSpeciesExactMatch FMA:67909 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002070 type I vestibular sensory cell semapv:crossSpeciesExactMatch FMA:62352 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002071 enterocyte of epithelium of large intestine semapv:crossSpeciesExactMatch FMA:63638 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002071 enterocyte of epithelium of large intestine semapv:crossSpeciesExactMatch FMA:66771 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002072 nodal myocyte semapv:crossSpeciesExactMatch FMA:67101 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002073 transitional myocyte semapv:crossSpeciesExactMatch FMA:67142 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002074 myocardial endocrine cell semapv:crossSpeciesExactMatch FMA:67111 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002076 semapv:crossSpeciesExactMatch ZFA:0009383 endo-epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002076 endo-epithelial cell semapv:crossSpeciesExactMatch FMA:69075 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002077 semapv:crossSpeciesExactMatch ZFA:0009385 ecto-epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002077 ecto-epithelial cell semapv:crossSpeciesExactMatch FMA:69074 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002078 semapv:crossSpeciesExactMatch ZFA:0009388 meso-epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002078 meso-epithelial cell semapv:crossSpeciesExactMatch FMA:69076 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002079 semapv:crossSpeciesExactMatch ZFA:0009380 pancreatic ductal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002079 pancreatic ductal cell semapv:crossSpeciesExactMatch FMA:63099 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002080 semapv:crossSpeciesExactMatch ZFA:0005740 pancreatic centroacinar cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002080 pancreatic centro-acinar cell semapv:crossSpeciesExactMatch FMA:62455 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002081 type II cell of carotid body semapv:crossSpeciesExactMatch FMA:84187 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002082 type II cell of adrenal medulla semapv:crossSpeciesExactMatch FMA:69322 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002083 type I cell of adrenal medulla semapv:crossSpeciesExactMatch FMA:69321 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002085 tanycyte semapv:crossSpeciesExactMatch FMA:54560 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002086 specialized cardiac myocyte semapv:crossSpeciesExactMatch FMA:67968 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002087 nongranular leukocyte semapv:crossSpeciesExactMatch FMA:62855 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002088 interstitial cell of Cajal semapv:crossSpeciesExactMatch FMA:86573 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002090 polar body semapv:crossSpeciesExactMatch EHDAA2:0004716 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002090 polar body semapv:crossSpeciesExactMatch WBbt:0008429 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002090 polar body semapv:crossSpeciesExactMatch XAO:0000262 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002090 polar body semapv:crossSpeciesExactMatch FMA:85543 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002091 primary polar body skos:broadMatch VHOG:0000464 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002091 primary polar body semapv:crossSpeciesExactMatch EHDAA2:0000541 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002091 primary polar body semapv:crossSpeciesExactMatch EMAPA:16032 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002091 primary polar body semapv:crossSpeciesExactMatch FMA:18650 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002092 bone marrow cell semapv:crossSpeciesExactMatch FMA:83621 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002093 secondary polar body semapv:crossSpeciesExactMatch EHDAA2:0001820 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002093 secondary polar body semapv:crossSpeciesExactMatch EMAPA:16034 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002093 secondary polar body semapv:crossSpeciesExactMatch EMAPA:16045 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002093 secondary polar body semapv:crossSpeciesExactMatch FMA:18651 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002094 interstitial cell of ovary semapv:crossSpeciesExactMatch FMA:18709 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002095 hilus cell of ovary semapv:crossSpeciesExactMatch FMA:18710 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002096 internodal tract myocyte semapv:crossSpeciesExactMatch FMA:223275 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002097 cortical cell of adrenal gland semapv:crossSpeciesExactMatch FMA:69545 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002098 regular cardiac myocyte semapv:crossSpeciesExactMatch FMA:67967 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002099 type I cell of adrenal cortex semapv:crossSpeciesExactMatch FMA:69273 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002100 regular interventricular cardiac myocyte semapv:crossSpeciesExactMatch FMA:228792 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002129 regular atrial cardiac myocyte semapv:crossSpeciesExactMatch FMA:83108 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002130 regular interatrial cardiac myocyte semapv:crossSpeciesExactMatch FMA:228790 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002131 regular ventricular cardiac myocyte semapv:crossSpeciesExactMatch FMA:83109 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002132 stromal cell of ovary semapv:crossSpeciesExactMatch FMA:72299 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002133 stromal cell of ovarian cortex semapv:crossSpeciesExactMatch FMA:256169 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002134 stromal cell of ovarian medulla semapv:crossSpeciesExactMatch FMA:256171 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002135 nonkeratinized cell of epidermis semapv:crossSpeciesExactMatch FMA:62880 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002136 type II cell of adrenal cortex semapv:crossSpeciesExactMatch FMA:69547 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002137 type III cell of adrenal cortex semapv:crossSpeciesExactMatch FMA:69564 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002138 endothelial cell of lymphatic vessel semapv:crossSpeciesExactMatch FMA:68458 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002139 endothelial cell of vascular tree semapv:crossSpeciesExactMatch FMA:67755 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002140 acinar cell of sebaceous gland semapv:crossSpeciesExactMatch FMA:70953 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002141 active chief cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69082 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002142 dark cell of eccrine sweat gland semapv:crossSpeciesExactMatch FMA:70659 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002143 dark chief cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69080 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002144 capillary endothelial cell semapv:crossSpeciesExactMatch FMA:67756 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002145 ciliated columnar cell of tracheobronchial tree semapv:crossSpeciesExactMatch FMA:70542 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002146 clear cell of eccrine sweat gland semapv:crossSpeciesExactMatch FMA:70658 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002147 clear chief cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69081 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002148 dental pulp cell semapv:crossSpeciesExactMatch FMA:87170 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002149 epithelial cell of uterus semapv:crossSpeciesExactMatch FMA:256161 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002150 epithelioid macrophage semapv:crossSpeciesExactMatch FMA:83514 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002151 late promyelocyte semapv:crossSpeciesExactMatch FMA:83534 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002152 columnar cell of endocervix semapv:crossSpeciesExactMatch FMA:86486 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002153 corneocyte semapv:crossSpeciesExactMatch FMA:68650 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002154 early promyelocyte semapv:crossSpeciesExactMatch FMA:83533 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002155 echinocyte semapv:crossSpeciesExactMatch FMA:81099 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002157 endosteal cell semapv:crossSpeciesExactMatch FMA:86495 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002158 external epithelial cell of tympanic membrane semapv:crossSpeciesExactMatch FMA:70558 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002159 general ecto-epithelial cell semapv:crossSpeciesExactMatch FMA:70556 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002162 internal epithelial cell of tympanic membrane semapv:crossSpeciesExactMatch FMA:70626 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002163 internal pillar cell of cochlea semapv:crossSpeciesExactMatch FMA:75726 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002164 external pillar cell of cochlea semapv:crossSpeciesExactMatch FMA:75727 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002165 phalangeal cell semapv:crossSpeciesExactMatch FMA:79800 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002166 epithelial cell of Malassez semapv:crossSpeciesExactMatch FMA:62987 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002167 olfactory epithelial cell semapv:crossSpeciesExactMatch FMA:67870 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002168 border cell of cochlea semapv:crossSpeciesExactMatch FMA:79798 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002169 basal cell of olfactory epithelium semapv:crossSpeciesExactMatch FMA:62303 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002171 globose cell of olfactory epithelium semapv:crossSpeciesExactMatch FMA:67874 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002172 interdental cell of cochlea semapv:crossSpeciesExactMatch FMA:79797 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002173 extraglomerular mesangial cell semapv:crossSpeciesExactMatch KUPO:0001033 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002173 extraglomerular mesangial cell semapv:crossSpeciesExactMatch FMA:84143 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002174 follicular cell of ovary semapv:crossSpeciesExactMatch EMAPA:31247 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002174 follicular cell of ovary semapv:crossSpeciesExactMatch FMA:70589 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002175 primary follicular cell of ovary semapv:crossSpeciesExactMatch FMA:70590 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002176 secondary follicular cell of ovary semapv:crossSpeciesExactMatch FMA:70591 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002177 folliculostellate cell of pars distalis of adenohypophysis semapv:crossSpeciesExactMatch FMA:83102 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002178 epithelial cell of stomach semapv:crossSpeciesExactMatch FMA:62948 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002179 foveolar cell of stomach semapv:crossSpeciesExactMatch FMA:86552 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002180 mucous cell of stomach semapv:crossSpeciesExactMatch FMA:63464 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002181 mucous neck cell of gastric gland semapv:crossSpeciesExactMatch FMA:62954 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002182 surface mucosal cell of stomach semapv:crossSpeciesExactMatch FMA:62949 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002183 stem cell of gastric gland semapv:crossSpeciesExactMatch FMA:62953 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002184 basal proper cell of olfactory epithelium semapv:crossSpeciesExactMatch FMA:62304 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002187 basal cell of epidermis semapv:crossSpeciesExactMatch FMA:70571 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002188 glomerular endothelial cell semapv:crossSpeciesExactMatch FMA:70970 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002189 granular cell of epidermis semapv:crossSpeciesExactMatch FMA:70543 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002190 squamous cell of epidermis semapv:crossSpeciesExactMatch FMA:86925 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002191 granulocytopoietic cell semapv:crossSpeciesExactMatch FMA:83519 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002192 metamyelocyte semapv:crossSpeciesExactMatch FMA:83541 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002193 myelocyte semapv:crossSpeciesExactMatch FMA:83525 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002194 monopoietic cell semapv:crossSpeciesExactMatch FMA:83552 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002195 hepatic stem cell semapv:crossSpeciesExactMatch FMA:86577 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002196 hepatic oval stem cell semapv:crossSpeciesExactMatch FMA:86576 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002198 oncocyte semapv:crossSpeciesExactMatch FMA:67606 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002199 oxyphil cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69084 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002200 oxyphil cell of thyroid semapv:crossSpeciesExactMatch FMA:87169 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002202 epithelial cell of tracheobronchial tree semapv:crossSpeciesExactMatch FMA:66816 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002203 brush cell of epithelium proper of large intestine semapv:crossSpeciesExactMatch FMA:263222 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002204 brush cell semapv:crossSpeciesExactMatch FMA:67978 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002205 brush cell of lobular bronchiole semapv:crossSpeciesExactMatch FMA:263220 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002206 brush cell of terminal bronchiole semapv:crossSpeciesExactMatch FMA:263228 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002207 brush cell of trachea semapv:crossSpeciesExactMatch FMA:263224 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002208 brush cell of bronchus semapv:crossSpeciesExactMatch FMA:263226 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002209 intermediate epitheliocyte semapv:crossSpeciesExactMatch FMA:69060 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002210 red muscle cell semapv:crossSpeciesExactMatch FMA:84448 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002211 type I muscle cell semapv:crossSpeciesExactMatch FMA:84413 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002212 type II muscle cell semapv:crossSpeciesExactMatch FMA:84414 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002213 white muscle cell semapv:crossSpeciesExactMatch FMA:84449 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002214 type IIa muscle cell semapv:crossSpeciesExactMatch FMA:84415 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002215 type IIb muscle cell semapv:crossSpeciesExactMatch FMA:84416 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002216 intermediate muscle cell semapv:crossSpeciesExactMatch FMA:84450 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002217 intermediate trophoblast cell semapv:crossSpeciesExactMatch FMA:86564 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002220 interstitial cell of pineal gland semapv:crossSpeciesExactMatch FMA:86575 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002221 keratinized squamous cell of esophagus semapv:crossSpeciesExactMatch FMA:86549 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002222 vertebrate lens cell semapv:crossSpeciesExactMatch FMA:70950 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002223 anterior lens cell semapv:crossSpeciesExactMatch FMA:63181 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002224 lens epithelial cell semapv:crossSpeciesExactMatch FMA:67559 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002226 non-nucleated secondary lens fiber semapv:crossSpeciesExactMatch FMA:67561 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002227 nucleated secondary lens fiber semapv:crossSpeciesExactMatch FMA:70949 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002228 primary lens fiber semapv:crossSpeciesExactMatch FMA:70613 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002229 light chief cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69079 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002231 epithelial cell of prostate semapv:crossSpeciesExactMatch FMA:256163 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002231 epithelial cell of prostate semapv:crossSpeciesExactMatch FMA:66817 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002232 epithelial cell of prostatic duct semapv:crossSpeciesExactMatch FMA:74224 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002233 epithelial cell of prostatic acinus semapv:crossSpeciesExactMatch FMA:74223 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002234 basal cell of prostatic acinus semapv:crossSpeciesExactMatch FMA:74265 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002235 luminal cell of prostatic acinus semapv:crossSpeciesExactMatch FMA:74266 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002236 basal epithelial cell of prostatic duct semapv:crossSpeciesExactMatch FMA:74226 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002237 luminal epithelial cell of prostatic duct semapv:crossSpeciesExactMatch FMA:74225 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002238 male gonocyte skos:broadMatch VHOG:0000662 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002238 male gonocyte semapv:crossSpeciesExactMatch EHDAA2:0001053 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002238 male gonocyte semapv:crossSpeciesExactMatch EMAPA:18686 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002238 male gonocyte semapv:crossSpeciesExactMatch FMA:84771 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002239 ooblast skos:broadMatch VHOG:0000661 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002239 ooblast semapv:crossSpeciesExactMatch EHDAA2:0000505 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002239 ooblast semapv:crossSpeciesExactMatch EMAPA:17965 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002239 ooblast semapv:crossSpeciesExactMatch FMA:84772 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002240 marrow fibroblast semapv:crossSpeciesExactMatch FMA:84377 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002241 pulmonary interstitial fibroblast semapv:crossSpeciesExactMatch FMA:84467 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002242 nucleate cell semapv:crossSpeciesExactMatch FMA:67513 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002243 smooth muscle cell of sphincter of pupil semapv:crossSpeciesExactMatch FMA:70611 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002244 squamous cell of ectocervix semapv:crossSpeciesExactMatch FMA:86483 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002246 peripheral blood stem cell semapv:crossSpeciesExactMatch FMA:86711 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002247 pleural macrophage semapv:crossSpeciesExactMatch FMA:83024 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002248 pluripotent stem cell semapv:crossSpeciesExactMatch FMA:70570 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002249 primitive cardiac myocyte semapv:crossSpeciesExactMatch FMA:75620 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002250 intestinal crypt stem cell semapv:crossSpeciesExactMatch FMA:63379 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002252 semapv:crossSpeciesExactMatch ZFA:0009400 epithelial cell of esophagus semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002252 epithelial cell of esophagus semapv:crossSpeciesExactMatch FMA:63071 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002253 epithelial cell of large intestine semapv:crossSpeciesExactMatch FMA:256157 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002254 epithelial cell of small intestine semapv:crossSpeciesExactMatch FMA:256159 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002255 stromal cell of endometrium semapv:crossSpeciesExactMatch FMA:86490 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002256 supporting cell of carotid body semapv:crossSpeciesExactMatch FMA:84188 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002257 epithelial cell of thyroid gland semapv:crossSpeciesExactMatch FMA:256167 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002258 thyroid follicular cell semapv:crossSpeciesExactMatch FMA:68782 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002259 neuroepithelial stem cell semapv:crossSpeciesExactMatch FMA:87171 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002260 epithelial cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:70547 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002261 endothelial cell of viscerocranial mucosa semapv:crossSpeciesExactMatch FMA:70627 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002262 endothelial cell of sinusoid semapv:crossSpeciesExactMatch FMA:63134 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002263 transitional cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69324 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002264 type A cell of stomach semapv:crossSpeciesExactMatch FMA:83411 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002265 type D cell of colon semapv:crossSpeciesExactMatch FMA:268744 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002266 type D cell of small intestine semapv:crossSpeciesExactMatch FMA:268736 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002267 type D cell of stomach semapv:crossSpeciesExactMatch FMA:83410 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002268 P/D1 enteroendocrine cell semapv:crossSpeciesExactMatch FMA:63418 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002270 type EC2 enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62941 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002271 type EC1 enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62940 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002273 type ECL enteroendocrine cell semapv:crossSpeciesExactMatch FMA:63208 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002275 semapv:crossSpeciesExactMatch ZFA:0005742 pancreatic PP cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002275 pancreatic PP cell semapv:crossSpeciesExactMatch FMA:70588 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002277 type I enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62937 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002278 GIP cell semapv:crossSpeciesExactMatch FMA:62942 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002279 type L enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62944 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002280 type N enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62943 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002281 type S enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62936 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002282 type TG enteroendocrine cell semapv:crossSpeciesExactMatch FMA:63421 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002283 ecto-epithelial cell of viscerocranial mucosa semapv:crossSpeciesExactMatch FMA:70581 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002284 type X enteroendocrine cell semapv:crossSpeciesExactMatch FMA:63209 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002285 type III taste bud cell semapv:crossSpeciesExactMatch FMA:67940 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002286 type II taste cell semapv:crossSpeciesExactMatch FMA:62381 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002287 type IV taste receptor cell semapv:crossSpeciesExactMatch FMA:62380 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002288 type V taste receptor cell semapv:crossSpeciesExactMatch FMA:67941 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002289 type I taste bud cell semapv:crossSpeciesExactMatch FMA:62356 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002290 Y chromosome-bearing sperm cell semapv:crossSpeciesExactMatch FMA:84058 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002291 X chromosome-bearing sperm cell semapv:crossSpeciesExactMatch FMA:84057 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002292 type I cell of carotid body semapv:crossSpeciesExactMatch FMA:84186 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002293 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72208 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002294 type-1 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72209 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002295 type-6 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72214 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002296 type-4 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72212 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002297 type-3 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72211 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002298 type-5 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72213 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002299 type-2 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72210 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002301 type B synovial cell semapv:crossSpeciesExactMatch FMA:66788 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002302 type A synovial cell semapv:crossSpeciesExactMatch FMA:66787 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002303 pigmented ciliary epithelial cell semapv:crossSpeciesExactMatch FMA:70606 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002304 non-pigmented ciliary epithelial cell semapv:crossSpeciesExactMatch FMA:70607 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002305 epithelial cell of distal tubule semapv:crossSpeciesExactMatch KUPO:0001055 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002305 epithelial cell of distal tubule semapv:crossSpeciesExactMatch FMA:70981 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002306 epithelial cell of proximal tubule semapv:crossSpeciesExactMatch KUPO:0001044 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002306 epithelial cell of proximal tubule semapv:crossSpeciesExactMatch FMA:70973 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002308 epithelial cell of skin gland semapv:crossSpeciesExactMatch FMA:70657 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002309 corticotroph semapv:crossSpeciesExactMatch FMA:83098 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002310 mammosomatotroph semapv:crossSpeciesExactMatch FMA:83097 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002311 mammotroph semapv:crossSpeciesExactMatch FMA:83096 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002312 somatotroph semapv:crossSpeciesExactMatch FMA:83095 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002313 endocrine-paracrine cell of prostate gland semapv:crossSpeciesExactMatch FMA:74390 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002313 endocrine-paracrine cell of prostate gland semapv:crossSpeciesExactMatch FMA:86774 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002314 external supporting cell of vestibular epithelium semapv:crossSpeciesExactMatch FMA:75809 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002315 supporting cell of cochlea semapv:crossSpeciesExactMatch FMA:79796 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002316 supporting cell of vestibular epithelium semapv:crossSpeciesExactMatch FMA:75607 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002317 external limiting cell of vestibular epithelium semapv:crossSpeciesExactMatch FMA:75808 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002318 peripheral blood mesothelial cell semapv:crossSpeciesExactMatch FMA:86712 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002319 neural cell semapv:crossSpeciesExactMatch FMA:70333 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002320 semapv:crossSpeciesExactMatch ZFA:0009392 connective tissue cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002320 connective tissue cell semapv:crossSpeciesExactMatch FMA:63875 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002321 semapv:crossSpeciesExactMatch ZFA:0007089 embryonic cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002321 embryonic cell (metazoa) semapv:crossSpeciesExactMatch WBbt:0007028 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002321 embryonic cell (metazoa) semapv:crossSpeciesExactMatch FMA:82840 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002322 embryonic stem cell semapv:crossSpeciesExactMatch FMA:82841 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002324 basal-myoepithelial cell of mammary gland semapv:crossSpeciesExactMatch FMA:67800 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002325 lactocyte semapv:crossSpeciesExactMatch FMA:74506 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002325 lactocyte semapv:crossSpeciesExactMatch FMA:79866 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002326 luminal epithelial cell of mammary gland semapv:crossSpeciesExactMatch FMA:73280 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002350 endocardial cell semapv:crossSpeciesExactMatch FMA:75621 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002371 semapv:crossSpeciesExactMatch ZFA:0009386 somatic cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002372 semapv:crossSpeciesExactMatch FBbt:00005812 myotube semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0002377 semapv:crossSpeciesExactMatch ZFA:0001725 immature Schwann cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002377 immature Schwann cell semapv:crossSpeciesExactMatch ZFA:0001725 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002379 meningothelial cell semapv:crossSpeciesExactMatch FMA:86588 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002422 enucleated reticulocyte semapv:crossSpeciesExactMatch FMA:66785 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002450 semapv:crossSpeciesExactMatch ZFA:0005565 tether cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002494 cardiocyte semapv:crossSpeciesExactMatch FMA:83808 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002494 cardiocyte semapv:crossSpeciesExactMatch FMA:84791 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002497 primary trophoblast giant cell semapv:crossSpeciesExactMatch EMAPA:16066 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002501 type D1 enteroendocrine cell semapv:crossSpeciesExactMatch FMA:63207 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002502 type M enteroendocrine cell semapv:crossSpeciesExactMatch FMA:63420 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002503 adventitial cell semapv:crossSpeciesExactMatch FMA:84639 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002518 semapv:crossSpeciesExactMatch ZFA:0009374 kidney epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002518 kidney epithelial cell semapv:crossSpeciesExactMatch KUPO:0001019 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002538 semapv:crossSpeciesExactMatch ZFA:0009379 intrahepatic bile duct epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002543 vein endothelial cell semapv:crossSpeciesExactMatch KUPO:0001099 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002543 vein endothelial cell semapv:crossSpeciesExactMatch FMA:62104 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002546 semapv:crossSpeciesExactMatch ZFA:0005773 embryonic blood vessel endothelial progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002563 semapv:crossSpeciesExactMatch ZFA:0009399 intestinal epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0002584 renal cortical epithelial cell semapv:crossSpeciesExactMatch KUPO:0001016 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002586 retinal pigment epithelial cell semapv:crossSpeciesExactMatch FMA:75802 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002597 smooth muscle cell of bladder semapv:crossSpeciesExactMatch KUPO:0001122 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002635 nonkeratinized epithelial cell of anal column semapv:crossSpeciesExactMatch FMA:263146 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002636 nonkeratinized epithelial cell of inferior part of anal canal semapv:crossSpeciesExactMatch FMA:263144 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002641 epithelial cell of esophageal gland proper semapv:crossSpeciesExactMatch FMA:256141 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002642 epithelial cell of esophageal cardiac gland semapv:crossSpeciesExactMatch FMA:256143 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002643 nonkeratinized cell of stratum corneum of esophageal epithelium semapv:crossSpeciesExactMatch FMA:263148 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002644 endo-epithelial cell of tympanic part of viscerocranial mucosa semapv:crossSpeciesExactMatch FMA:70628 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002645 endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa semapv:crossSpeciesExactMatch FMA:70629 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002651 endothelial cell of venous sinus of spleen semapv:crossSpeciesExactMatch FMA:72140 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002652 endothelial cell of high endothelial venule semapv:crossSpeciesExactMatch FMA:67759 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002654 epithelial cell of stratum corneum of esophageal epithelium semapv:crossSpeciesExactMatch FMA:70733 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002655 epithelial cell of stratum spinosum of esophageal epithelium semapv:crossSpeciesExactMatch FMA:70732 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002656 glandular cell of endometrium semapv:crossSpeciesExactMatch FMA:86489 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002657 glandular cell of esophagus semapv:crossSpeciesExactMatch FMA:86548 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002658 glandular cell of the large intestine semapv:crossSpeciesExactMatch FMA:87194 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002659 glandular epithelial cell of stomach semapv:crossSpeciesExactMatch FMA:86554 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002660 luminal cell of acinus of lactiferous gland semapv:crossSpeciesExactMatch FMA:74505 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002661 luminal cell of lactiferous terminal ductal lobular unit semapv:crossSpeciesExactMatch FMA:87168 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002662 luminal cell of lactiferous duct semapv:crossSpeciesExactMatch FMA:74504 semapv:UnspecifiedMatching obo:cl.owl
-CL:0002663 myocardial endocrine cell of atrium semapv:crossSpeciesExactMatch FMA:83389 semapv:UnspecifiedMatching obo:cl.owl
-CL:0005000 semapv:crossSpeciesExactMatch ZFA:0000778 spinal cord interneuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005001 semapv:crossSpeciesExactMatch ZFA:0005328 iridoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005002 semapv:crossSpeciesExactMatch ZFA:0005245 xanthoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005003 semapv:crossSpeciesExactMatch ZFA:0005329 leucoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005004 semapv:crossSpeciesExactMatch ZFA:0005331 pigment erythroblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005005 semapv:crossSpeciesExactMatch ZFA:0005332 cyanoblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005006 semapv:crossSpeciesExactMatch ZFA:0005323 ionocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005007 semapv:crossSpeciesExactMatch ZFA:0005240 Kolmer-Agduhr neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005009 semapv:crossSpeciesExactMatch ZFA:0005322 renal principal cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005010 semapv:crossSpeciesExactMatch ZFA:0009375 renal intercalated cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005010 renal intercalated cell semapv:crossSpeciesExactMatch FMA:86560 semapv:UnspecifiedMatching obo:cl.owl
-CL:0005011 semapv:crossSpeciesExactMatch ZFA:0009376 renal alpha-intercalated cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005012 semapv:crossSpeciesExactMatch ZFA:0005242 multi-ciliated epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005013 semapv:crossSpeciesExactMatch ZFA:0005243 single ciliated epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005014 semapv:crossSpeciesExactMatch ZFA:0005244 auditory epithelial support cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005015 inner phalangeal cell semapv:crossSpeciesExactMatch FMA:79801 semapv:UnspecifiedMatching obo:cl.owl
-CL:0005018 semapv:crossSpeciesExactMatch ZFA:0005599 ghrelin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005019 semapv:crossSpeciesExactMatch ZFA:0005598 pancreatic epsilon cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005020 semapv:crossSpeciesExactMatch ZFA:0009393 lymphangioblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005021 semapv:crossSpeciesExactMatch ZFA:0009394 mesenchymal lymphangioblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005022 semapv:crossSpeciesExactMatch ZFA:0009395 vascular lymphangioblast semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005023 semapv:crossSpeciesExactMatch ZFA:0005731 branchiomotor neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005024 semapv:crossSpeciesExactMatch ZFA:0005733 somatomotor neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0005025 semapv:crossSpeciesExactMatch ZFA:0005732 visceromotor neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0007004 semapv:crossSpeciesExactMatch ZFA:0007084 premigratory neural crest cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0007007 semapv:crossSpeciesExactMatch ZFA:0005744 notochord outer sheath cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0007011 semapv:crossSpeciesExactMatch ZFA:0005775 enteric neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0007016 semapv:crossSpeciesExactMatch ZFA:0000003 adaxial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0007022 semapv:crossSpeciesExactMatch ZFA:0005239 micropylar cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0008004 semapv:crossSpeciesExactMatch FBbt:00005073 somatic muscle cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0008007 semapv:crossSpeciesExactMatch FBbt:00005070 visceral muscle cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0008025 semapv:crossSpeciesExactMatch ZFA:0005873 noradrenergic neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0008026 semapv:crossSpeciesExactMatch FBbt:00005038 tracheocyte semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0008034 semapv:crossSpeciesExactMatch ZFA:0005944 mural cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0008037 gamma motor neuron semapv:crossSpeciesExactMatch FMA:83660 semapv:UnspecifiedMatching obo:cl.owl
-CL:0008039 lower motor neuron semapv:crossSpeciesExactMatch FMA:84632 semapv:UnspecifiedMatching obo:cl.owl
-CL:0010012 cerebral cortex neuron semapv:crossSpeciesExactMatch FMA:84104 semapv:UnspecifiedMatching obo:cl.owl
-CL:0011004 semapv:crossSpeciesExactMatch ZFA:0009401 lens fiber cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:0011102 semapv:crossSpeciesExactMatch ZFA:0005776 parasympathetic neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0011103 semapv:crossSpeciesExactMatch ZFA:0005777 sympathetic neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0011109 semapv:crossSpeciesExactMatch ZFA:0005778 hypocretin-secreting neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0011110 semapv:crossSpeciesExactMatch FBbt:00007367 histaminergic neuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:0015000 semapv:crossSpeciesExactMatch ZFA:0005730 cranial motor neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:0017005 lymphoblast semapv:crossSpeciesExactMatch FMA:83030 semapv:UnspecifiedMatching obo:cl.owl
-CL:0017006 B-lymphoblast semapv:crossSpeciesExactMatch FMA:83031 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000082 semapv:crossSpeciesExactMatch ZFA:0009370 stretch receptor cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:1000083 semapv:crossSpeciesExactMatch ZFA:0009371 stratified keratinized epithelial stem cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:1000147 semapv:crossSpeciesExactMatch ZFA:0009402 heart valve cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:1000155 semapv:crossSpeciesExactMatch FBbt:00005797 Malpighian tubule Type II cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:1000191 pillar cell semapv:crossSpeciesExactMatch FMA:75722 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000275 smooth muscle cell of small intestine semapv:crossSpeciesExactMatch FMA:15050 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000276 smooth muscle fiber of duodenum semapv:crossSpeciesExactMatch FMA:15058 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000277 smooth muscle fiber of jejunum semapv:crossSpeciesExactMatch FMA:15062 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000278 smooth muscle fiber of ileum semapv:crossSpeciesExactMatch FMA:15066 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000279 smooth muscle cell of large intestine semapv:crossSpeciesExactMatch FMA:15653 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000280 smooth muscle cell of colon semapv:crossSpeciesExactMatch FMA:15663 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000281 smooth muscle cell of cecum semapv:crossSpeciesExactMatch FMA:15681 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000282 smooth muscle fiber of ascending colon semapv:crossSpeciesExactMatch FMA:17518 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000283 smooth muscle fiber of transverse colon semapv:crossSpeciesExactMatch FMA:17519 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000284 smooth muscle fiber of descending colon semapv:crossSpeciesExactMatch FMA:17520 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000285 smooth muscle cell of sigmoid colon semapv:crossSpeciesExactMatch FMA:17521 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000286 smooth muscle cell of rectum semapv:crossSpeciesExactMatch FMA:17522 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000287 myocyte of anterior internodal tract semapv:crossSpeciesExactMatch FMA:223276 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000288 myocyte of atrial branch of anterior internodal tract semapv:crossSpeciesExactMatch FMA:223277 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000289 myocyte of atrial septal branch of anterior internodal tract semapv:crossSpeciesExactMatch FMA:223278 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000290 myocyte of middle internodal tract semapv:crossSpeciesExactMatch FMA:223279 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000291 myocyte of posterior internodal tract semapv:crossSpeciesExactMatch FMA:223280 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000296 epithelial cell of urethra semapv:crossSpeciesExactMatch FMA:256165 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000298 mesothelial cell of dura mater semapv:crossSpeciesExactMatch FMA:256516 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000299 fibroblast of connective tissue of prostate semapv:crossSpeciesExactMatch FMA:261271 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000300 fibroblast of outer membrane of prostatic capsule semapv:crossSpeciesExactMatch FMA:261273 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000301 fibroblast of subepithelial connective tissue of prostatic gland semapv:crossSpeciesExactMatch FMA:261275 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000302 fibroblast of papillary layer of dermis semapv:crossSpeciesExactMatch FMA:261277 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000303 fibroblast of areolar connective tissue semapv:crossSpeciesExactMatch FMA:261279 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000304 fibroblast of connective tissue of nonglandular part of prostate semapv:crossSpeciesExactMatch FMA:261281 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000305 fibroblast of connective tissue of glandular part of prostate semapv:crossSpeciesExactMatch FMA:261283 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000306 fibroblast of tunica adventitia of artery semapv:crossSpeciesExactMatch FMA:261285 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000307 fibroblast of dense regular elastic tissue semapv:crossSpeciesExactMatch FMA:261287 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000308 fibrocyte of adventitia of ureter semapv:crossSpeciesExactMatch FMA:261289 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000309 epicardial adipocyte semapv:crossSpeciesExactMatch FMA:261293 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000310 adipocyte of epicardial fat of right ventricle semapv:crossSpeciesExactMatch FMA:261297 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000311 adipocyte of epicardial fat of left ventricle semapv:crossSpeciesExactMatch FMA:261300 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000312 bronchial goblet cell semapv:crossSpeciesExactMatch FMA:263032 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000313 gastric goblet cell semapv:crossSpeciesExactMatch FMA:263035 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000314 gastric cardiac gland goblet cell semapv:crossSpeciesExactMatch FMA:263038 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000315 principal gastric gland goblet cell semapv:crossSpeciesExactMatch FMA:263040 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000317 intestinal villus goblet cell semapv:crossSpeciesExactMatch FMA:263046 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000320 large intestine goblet cell semapv:crossSpeciesExactMatch FMA:263054 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000321 large intestine crypt goblet cell semapv:crossSpeciesExactMatch FMA:263056 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000322 pancreatic goblet cell semapv:crossSpeciesExactMatch FMA:263058 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000323 pyloric gastric gland goblet cell semapv:crossSpeciesExactMatch FMA:263061 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000324 duodenal goblet cell semapv:crossSpeciesExactMatch FMA:263063 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000325 jejunal goblet cell semapv:crossSpeciesExactMatch FMA:263065 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000326 ileal goblet cell semapv:crossSpeciesExactMatch FMA:263067 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000327 appendix goblet cell semapv:crossSpeciesExactMatch FMA:263069 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000329 tracheal goblet cell semapv:crossSpeciesExactMatch FMA:263075 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000330 serous cell of epithelium of trachea semapv:crossSpeciesExactMatch FMA:263078 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000331 serous cell of epithelium of bronchus semapv:crossSpeciesExactMatch FMA:263080 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000332 serous cell of epithelium of terminal bronchiole semapv:crossSpeciesExactMatch FMA:263082 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000333 serous cell of epithelium of lobular bronchiole semapv:crossSpeciesExactMatch FMA:263084 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000334 enterocyte of epithelium of small intestine semapv:crossSpeciesExactMatch FMA:263086 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000335 enterocyte of epithelium of intestinal villus semapv:crossSpeciesExactMatch FMA:263088 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000337 enterocyte of epithelium of duodenal gland semapv:crossSpeciesExactMatch FMA:263092 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000338 enterocyte of epithelium of crypt of Lieberkuhn of small intestine semapv:crossSpeciesExactMatch FMA:263094 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000339 enterocyte of epithelium proper of small intestine semapv:crossSpeciesExactMatch FMA:263096 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000340 enterocyte of epithelium proper of duodenum semapv:crossSpeciesExactMatch FMA:263098 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000341 enterocyte of epithelium proper of jejunum semapv:crossSpeciesExactMatch FMA:263100 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000342 enterocyte of epithelium proper of ileum semapv:crossSpeciesExactMatch FMA:263102 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000343 paneth cell of epithelium of small intestine semapv:crossSpeciesExactMatch FMA:263104 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000344 paneth cell of epithelium proper of small intestine semapv:crossSpeciesExactMatch FMA:263106 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000345 paneth cell of epithelium of crypt of Lieberkuhn of small intestine semapv:crossSpeciesExactMatch FMA:263108 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000346 enterocyte of epithelium proper of large intestine semapv:crossSpeciesExactMatch FMA:263090 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000346 enterocyte of epithelium proper of large intestine semapv:crossSpeciesExactMatch FMA:263112 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000347 colonocyte semapv:crossSpeciesExactMatch FMA:263114 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000348 basal cell of epithelium of trachea semapv:crossSpeciesExactMatch FMA:263118 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000349 basal cell of epithelium of bronchus semapv:crossSpeciesExactMatch FMA:263120 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000350 basal cell of epithelium of terminal bronchiole semapv:crossSpeciesExactMatch FMA:263122 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000351 basal cell of epithelium of respiratory bronchiole semapv:crossSpeciesExactMatch FMA:263124 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000352 basal cell of epithelium of lobular bronchiole semapv:crossSpeciesExactMatch FMA:263126 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000353 microfold cell of epithelium of small intestine semapv:crossSpeciesExactMatch FMA:263128 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000354 microfold cell of epithelium of intestinal villus semapv:crossSpeciesExactMatch FMA:263130 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000355 microfold cell of epithelium proper of small intestine semapv:crossSpeciesExactMatch FMA:263132 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000356 microfold cell of epithelium proper of duodenum semapv:crossSpeciesExactMatch FMA:263134 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000357 microfold cell of epithelium proper of jejunum semapv:crossSpeciesExactMatch FMA:263136 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000358 microfold cell of epithelium proper of ileum semapv:crossSpeciesExactMatch FMA:263138 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000359 microfold cell of epithelium proper of appendix semapv:crossSpeciesExactMatch FMA:263140 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000360 microfold cell of epithelium proper of large intestine semapv:crossSpeciesExactMatch FMA:263142 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000361 transitional myocyte of interatrial septum semapv:crossSpeciesExactMatch FMA:263152 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000362 transitional myocyte of interventricular septum semapv:crossSpeciesExactMatch FMA:263154 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000363 transitional myocyte of atrial branch of anterior internodal tract semapv:crossSpeciesExactMatch FMA:263156 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000364 transitional myocyte of anterior internodal tract semapv:crossSpeciesExactMatch FMA:263158 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000365 transitional myocyte of atrial septal branch of anterior internodal tract semapv:crossSpeciesExactMatch FMA:263160 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000366 transitional myocyte of middle internodal tract semapv:crossSpeciesExactMatch FMA:263162 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000367 transitional myocyte of posterior internodal tract semapv:crossSpeciesExactMatch FMA:263164 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000368 transitional myocyte of anterior division of left branch of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263166 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000369 transitional myocyte of septal division of left branch of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263168 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000370 transitional myocyte of left branch of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263170 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000371 transitional myocyte of right branch of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263172 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000372 transitional myocyte of atrial part of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263174 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000373 transitional myocyte of ventricular part of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263176 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000374 transitional myocyte of posterior division of left branch of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263178 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000375 myocardial endocrine cell of septal division of left branch of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263180 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000376 Purkinje myocyte of interventricular septum semapv:crossSpeciesExactMatch FMA:263182 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000377 dense-core granulated cell of epithelium of trachea semapv:crossSpeciesExactMatch FMA:263184 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000378 type 1 vestibular sensory cell of stato-acoustic epithelium semapv:crossSpeciesExactMatch FMA:263186 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000379 type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth semapv:crossSpeciesExactMatch FMA:263188 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000380 type 1 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth semapv:crossSpeciesExactMatch FMA:263190 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000381 type 1 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth semapv:crossSpeciesExactMatch FMA:263192 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000382 type 2 vestibular sensory cell of stato-acoustic epithelium semapv:crossSpeciesExactMatch FMA:263194 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000383 type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth semapv:crossSpeciesExactMatch FMA:263196 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000384 type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth semapv:crossSpeciesExactMatch FMA:263198 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000385 type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth semapv:crossSpeciesExactMatch FMA:263200 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000391 melanocyte of eyelid semapv:crossSpeciesExactMatch FMA:59175 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000394 myoepithelial cell of intralobular lactiferous duct semapv:crossSpeciesExactMatch FMA:62158 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000397 endothelial cell of venous sinus of red pulp of spleen semapv:crossSpeciesExactMatch FMA:62817 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000398 endothelial cell of hepatic sinusoid semapv:crossSpeciesExactMatch FMA:62911 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000405 epithelial cell of appendix semapv:crossSpeciesExactMatch FMA:63602 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000409 myocyte of sinoatrial node semapv:crossSpeciesExactMatch FMA:67102 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000410 myocyte of atrioventricular node semapv:crossSpeciesExactMatch FMA:67106 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000411 endothelial cell of Peyer's patch semapv:crossSpeciesExactMatch FMA:67757 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000412 endothelial cell of arteriole semapv:crossSpeciesExactMatch KUPO:0001097 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000412 endothelial cell of arteriole semapv:crossSpeciesExactMatch FMA:67760 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000413 endothelial cell of artery semapv:crossSpeciesExactMatch KUPO:0001095 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000413 endothelial cell of artery semapv:crossSpeciesExactMatch FMA:67761 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000414 endothelial cell of venule semapv:crossSpeciesExactMatch FMA:67762 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000415 epithelial cell of gallbladder semapv:crossSpeciesExactMatch FMA:67780 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000417 myoepithelial cell of sweat gland semapv:crossSpeciesExactMatch FMA:67801 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000418 myoepithelial cell of lactiferous alveolus semapv:crossSpeciesExactMatch FMA:67802 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000419 myoepithelial cell of lactiferous duct semapv:crossSpeciesExactMatch FMA:67803 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000420 myoepithelial cell of terminal lactiferous duct semapv:crossSpeciesExactMatch FMA:67804 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000424 chromaffin cell of paraaortic body semapv:crossSpeciesExactMatch FMA:69328 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000425 chromaffin cell of paraganglion semapv:crossSpeciesExactMatch FMA:69335 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000426 chromaffin cell of adrenal gland semapv:crossSpeciesExactMatch FMA:69794 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000427 adrenal cortex chromaffin cell semapv:crossSpeciesExactMatch FMA:69795 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000428 semapv:crossSpeciesExactMatch ZFA:0007122 epidermal stem cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:1000428 stem cell of epidermis semapv:crossSpeciesExactMatch FMA:70541 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000432 conjunctival epithelial cell semapv:crossSpeciesExactMatch FMA:70552 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000433 epithelial cell of lacrimal canaliculus semapv:crossSpeciesExactMatch FMA:70553 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000434 epithelial cell of external acoustic meatus semapv:crossSpeciesExactMatch FMA:70555 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000435 epithelial cell of lacrimal drainage system semapv:crossSpeciesExactMatch FMA:70559 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000436 epithelial cell of lacrimal sac semapv:crossSpeciesExactMatch FMA:70560 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000437 epithelial cell of nasolacrimal duct semapv:crossSpeciesExactMatch FMA:70561 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000438 epithelial cell of wall of inferior part of anal canal semapv:crossSpeciesExactMatch FMA:70562 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000441 epithelial cell of viscerocranial mucosa semapv:crossSpeciesExactMatch FMA:70583 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000442 urothelial cell of trigone of urinary bladder semapv:crossSpeciesExactMatch FMA:70598 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000443 ciliary muscle cell semapv:crossSpeciesExactMatch FMA:70610 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000444 mesothelial cell of anterior chamber of eye semapv:crossSpeciesExactMatch FMA:70615 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000445 myoepithelial cell of dilator pupillae semapv:crossSpeciesExactMatch FMA:70619 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000447 epithelial cell of stratum germinativum of esophagus semapv:crossSpeciesExactMatch FMA:70731 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000448 epithelial cell of sweat gland semapv:crossSpeciesExactMatch FMA:70952 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000449 epithelial cell of nephron semapv:crossSpeciesExactMatch FMA:70965 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000450 epithelial cell of glomerular capsule semapv:crossSpeciesExactMatch KUPO:0001034 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000450 epithelial cell of glomerular capsule semapv:crossSpeciesExactMatch FMA:70966 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000452 parietal epithelial cell semapv:crossSpeciesExactMatch KUPO:0001035 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000452 parietal epithelial cell semapv:crossSpeciesExactMatch FMA:70968 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000453 epithelial cell of intermediate tubule semapv:crossSpeciesExactMatch FMA:70980 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000454 kidney collecting duct epithelial cell semapv:crossSpeciesExactMatch KUPO:0001059 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000454 kidney collecting duct epithelial cell semapv:crossSpeciesExactMatch FMA:70982 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000456 mesothelial cell of parietal peritoneum semapv:crossSpeciesExactMatch FMA:72142 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000457 mesothelial cell of visceral peritoneum semapv:crossSpeciesExactMatch FMA:72143 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000458 melanocyte of skin semapv:crossSpeciesExactMatch FMA:72144 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000465 chromaffin cell of ovary semapv:crossSpeciesExactMatch FMA:74319 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000466 chromaffin cell of right ovary semapv:crossSpeciesExactMatch FMA:74320 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000467 chromaffin cell of left ovary semapv:crossSpeciesExactMatch FMA:74321 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000468 myoepithelial cell of acinus of lactiferous gland semapv:crossSpeciesExactMatch FMA:74469 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000469 myoepithelial cell of main lactiferous duct semapv:crossSpeciesExactMatch FMA:74499 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000470 myoepithelial cell of primary lactiferous duct semapv:crossSpeciesExactMatch FMA:74500 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000471 myoepithelial cell of secondary lactiferous duct semapv:crossSpeciesExactMatch FMA:74501 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000472 myoepithelial cell of tertiary lactiferous duct semapv:crossSpeciesExactMatch FMA:74502 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000473 myoepithelial cell of quarternary lactiferous duct semapv:crossSpeciesExactMatch FMA:74503 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000477 cardiac pacemaker cell of sinoatrial node semapv:crossSpeciesExactMatch FMA:83383 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000478 transitional myocyte of sinoatrial node semapv:crossSpeciesExactMatch FMA:83384 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000479 Purkinje myocyte of atrioventricular node semapv:crossSpeciesExactMatch FMA:83386 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000480 transitional myocyte of internodal tract semapv:crossSpeciesExactMatch FMA:83387 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000481 transitional myocyte of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:83388 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000482 myocardial endocrine cell of interventricular septum semapv:crossSpeciesExactMatch FMA:83390 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000483 Purkinje myocyte of internodal tract semapv:crossSpeciesExactMatch FMA:83392 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000484 Purkinje myocyte of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:83393 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000486 basal cell of urothelium semapv:crossSpeciesExactMatch FMA:84150 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000487 smooth muscle cell of prostate semapv:crossSpeciesExactMatch FMA:84583 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000488 semapv:crossSpeciesExactMatch ZFA:0009397 cholangiocyte semapv:UnspecifiedMatching obo:zfa.owl
-CL:1000488 cholangiocyte semapv:crossSpeciesExactMatch FMA:86481 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000489 reticular cell of splenic cord semapv:crossSpeciesExactMatch FMA:86497 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000490 mesothelial cell of peritoneum semapv:crossSpeciesExactMatch FMA:86736 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000491 mesothelial cell of pleura semapv:crossSpeciesExactMatch FMA:86737 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000492 mesothelial cell of parietal pleura semapv:crossSpeciesExactMatch FMA:86738 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000493 mesothelial cell of visceral pleura semapv:crossSpeciesExactMatch FMA:86739 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000494 nephron tubule epithelial cell semapv:crossSpeciesExactMatch KUPO:0001022 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000494 nephron tubule epithelial cell semapv:crossSpeciesExactMatch FMA:86785 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000495 small intestine goblet cell semapv:crossSpeciesExactMatch FMA:86929 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000497 semapv:crossSpeciesExactMatch ZFA:0009389 kidney cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:1000497 kidney cell semapv:crossSpeciesExactMatch KUPO:0001010 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000500 semapv:crossSpeciesExactMatch ZFA:0009390 kidney interstitial cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:1000500 kidney interstitial cell semapv:crossSpeciesExactMatch KUPO:0001013 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000504 semapv:crossSpeciesExactMatch ZFA:0009391 kidney medulla cell semapv:UnspecifiedMatching obo:zfa.owl
-CL:1000504 kidney medulla cell semapv:crossSpeciesExactMatch KUPO:0001017 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000505 kidney pelvis cell semapv:crossSpeciesExactMatch KUPO:0001018 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000507 kidney tubule cell semapv:crossSpeciesExactMatch KUPO:0001020 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000510 kidney glomerular epithelial cell semapv:crossSpeciesExactMatch KUPO:0001023 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000546 kidney medulla collecting duct epithelial cell semapv:crossSpeciesExactMatch KUPO:0001060 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000547 kidney inner medulla collecting duct epithelial cell semapv:crossSpeciesExactMatch KUPO:0001061 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000548 kidney outer medulla collecting duct epithelial cell semapv:crossSpeciesExactMatch KUPO:0001062 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000549 kidney cortex collecting duct epithelial cell semapv:crossSpeciesExactMatch KUPO:0001063 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000550 kidney papillary duct principal epithelial cell semapv:crossSpeciesExactMatch KUPO:0001064 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000596 inner renal cortex cell semapv:crossSpeciesExactMatch KUPO:0001111 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000597 papillary tips cell semapv:crossSpeciesExactMatch KUPO:0001112 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000600 lower urinary tract cell semapv:crossSpeciesExactMatch KUPO:0001115 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000601 ureteral cell semapv:crossSpeciesExactMatch KUPO:0001116 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000606 kidney nerve cell semapv:crossSpeciesExactMatch KUPO:0001015 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000612 kidney corpuscule cell semapv:crossSpeciesExactMatch KUPO:0001021 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000615 kidney cortex tubule cell semapv:crossSpeciesExactMatch KUPO:0001024 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000616 kidney outer medulla cell semapv:crossSpeciesExactMatch KUPO:0001025 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000617 kidney inner medulla cell semapv:crossSpeciesExactMatch KUPO:0001026 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000618 juxtaglomerular complex cell semapv:crossSpeciesExactMatch KUPO:0001028 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000681 kidney cortex interstitial cell semapv:crossSpeciesExactMatch KUPO:0001091 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000682 kidney medulla interstitial cell semapv:crossSpeciesExactMatch KUPO:0001092 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000691 kidney interstitial myofibroblast semapv:crossSpeciesExactMatch KUPO:0001101 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000692 kidney interstitial fibroblast semapv:crossSpeciesExactMatch KUPO:0001102 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000693 kidney interstitial fibrocyte semapv:crossSpeciesExactMatch KUPO:0001103 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000695 kidney interstitial alternatively activated macrophage semapv:crossSpeciesExactMatch KUPO:0001106 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000696 kidney interstitial inflammatory macrophage semapv:crossSpeciesExactMatch KUPO:0001107 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000697 kidney interstitial suppressor macrophage semapv:crossSpeciesExactMatch KUPO:0001108 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000698 kidney resident macrophage semapv:crossSpeciesExactMatch KUPO:0001109 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000699 kidney resident dendritic cell semapv:crossSpeciesExactMatch KUPO:0001110 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000702 kidney pelvis smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001113 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000703 kidney pelvis urothelial cell semapv:crossSpeciesExactMatch KUPO:0001114 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000706 ureter urothelial cell semapv:crossSpeciesExactMatch KUPO:0001117 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000708 ureter adventitial cell semapv:crossSpeciesExactMatch KUPO:0001119 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000714 kidney cortex collecting duct principal cell semapv:crossSpeciesExactMatch KUPO:0001130 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000715 kidney cortex collecting duct intercalated cell semapv:crossSpeciesExactMatch KUPO:0001131 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000716 kidney outer medulla collecting duct principal cell semapv:crossSpeciesExactMatch KUPO:0001132 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000717 kidney outer medulla collecting duct intercalated cell semapv:crossSpeciesExactMatch KUPO:0001133 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000718 kidney inner medulla collecting duct principal cell semapv:crossSpeciesExactMatch KUPO:0001134 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000719 kidney inner medulla collecting duct intercalated cell semapv:crossSpeciesExactMatch KUPO:0001135 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000720 kidney papillary duct intercalated cell semapv:crossSpeciesExactMatch KUPO:0001136 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000721 kidney papillary duct principal cell semapv:crossSpeciesExactMatch KUPO:0001137 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000742 glomerular mesangial cell semapv:crossSpeciesExactMatch KUPO:0001032 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000746 glomerular cell semapv:crossSpeciesExactMatch KUPO:0001036 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000768 kidney connecting tubule epithelial cell semapv:crossSpeciesExactMatch KUPO:0001058 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000803 kidney inner medulla interstitial cell semapv:crossSpeciesExactMatch KUPO:0001093 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000804 kidney outer medulla interstitial cell semapv:crossSpeciesExactMatch KUPO:0001094 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000838 kidney proximal convoluted tubule epithelial cell semapv:crossSpeciesExactMatch KUPO:0001045 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000839 kidney proximal straight tubule epithelial cell semapv:crossSpeciesExactMatch KUPO:0001046 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000849 kidney distal convoluted tubule epithelial cell semapv:crossSpeciesExactMatch KUPO:0001056 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000850 macula densa epithelial cell semapv:crossSpeciesExactMatch KUPO:0001057 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000854 kidney blood vessel cell semapv:crossSpeciesExactMatch KUPO:0001014 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000891 kidney arterial blood vessel cell semapv:crossSpeciesExactMatch KUPO:0001029 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000892 kidney capillary endothelial cell semapv:crossSpeciesExactMatch KUPO:0001030 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000893 kidney venous blood vessel cell semapv:crossSpeciesExactMatch KUPO:0001031 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000909 kidney loop of Henle epithelial cell semapv:crossSpeciesExactMatch KUPO:0001047 semapv:UnspecifiedMatching obo:cl.owl
-CL:1000979 ureter smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001118 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001005 glomerular capillary endothelial cell semapv:crossSpeciesExactMatch KUPO:0001037 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001006 kidney afferent arteriole cell semapv:crossSpeciesExactMatch KUPO:0001038 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001009 kidney efferent arteriole cell semapv:crossSpeciesExactMatch KUPO:0001041 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001016 kidney loop of Henle ascending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001048 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001021 kidney loop of Henle descending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001053 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001033 peritubular capillary endothelial cell semapv:crossSpeciesExactMatch KUPO:0001065 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001036 vasa recta cell semapv:crossSpeciesExactMatch KUPO:0001068 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001045 kidney cortex artery cell semapv:crossSpeciesExactMatch KUPO:0001077 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001052 kidney cortex vein cell semapv:crossSpeciesExactMatch KUPO:0001084 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001064 kidney artery smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001096 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001066 kidney arteriole smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001098 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001068 kidney venous system smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001100 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001096 kidney afferent arteriole endothelial cell semapv:crossSpeciesExactMatch KUPO:0001039 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001097 kidney afferent arteriole smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001040 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001099 kidney efferent arteriole endothelial cell semapv:crossSpeciesExactMatch KUPO:0001042 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001100 kidney efferent arteriole smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001043 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001106 kidney loop of Henle thick ascending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001049 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001107 kidney loop of Henle thin ascending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001050 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001108 kidney loop of Henle medullary thick ascending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001051 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001109 kidney loop of Henle cortical thick ascending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001052 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001111 kidney loop of Henle thin descending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001054 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001123 kidney outer medulla peritubular capillary cell semapv:crossSpeciesExactMatch KUPO:0001066 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001124 kidney cortex peritubular capillary cell semapv:crossSpeciesExactMatch KUPO:0001067 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001126 inner renal medulla vasa recta cell semapv:crossSpeciesExactMatch KUPO:0001069 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001127 outer renal medulla vasa recta cell semapv:crossSpeciesExactMatch KUPO:0001070 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001131 vasa recta ascending limb cell semapv:crossSpeciesExactMatch KUPO:0001074 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001135 arcuate artery cell semapv:crossSpeciesExactMatch KUPO:0001078 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001138 interlobular artery cell semapv:crossSpeciesExactMatch KUPO:0001081 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001142 arcuate vein cell semapv:crossSpeciesExactMatch KUPO:0001085 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001145 interlobular vein cell semapv:crossSpeciesExactMatch KUPO:0001088 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001209 inner medulla vasa recta ascending limb cell semapv:crossSpeciesExactMatch KUPO:0001075 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001210 outer medulla vasa recta ascending limb cell semapv:crossSpeciesExactMatch KUPO:0001076 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001213 arcuate artery endothelial cell semapv:crossSpeciesExactMatch KUPO:0001079 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001214 arcuate artery smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001080 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001216 interlobulary artery endothelial cell semapv:crossSpeciesExactMatch KUPO:0001082 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001217 interlobulary artery smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001083 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001220 arcuate vein endothelial cell semapv:crossSpeciesExactMatch KUPO:0001086 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001221 arcuate vein smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001087 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001223 interlobulary vein endothelial cell semapv:crossSpeciesExactMatch KUPO:0001089 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001224 interlobulary vein smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001090 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001225 kidney collecting duct cell semapv:crossSpeciesExactMatch KUPO:0001012 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001285 vasa recta descending limb cell semapv:crossSpeciesExactMatch KUPO:0001071 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001286 inner medulla vasa recta descending limb cell semapv:crossSpeciesExactMatch KUPO:0001072 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001287 outer medulla vasa recta descending limb cell semapv:crossSpeciesExactMatch KUPO:0001073 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001318 renal interstitial pericyte semapv:crossSpeciesExactMatch KUPO:0001104 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001319 bladder cell semapv:crossSpeciesExactMatch KUPO:0001120 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001320 urethra cell semapv:crossSpeciesExactMatch KUPO:0001123 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001428 bladder urothelial cell skos:narrowMatch NCIT:C32210 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001428 bladder urothelial cell semapv:crossSpeciesExactMatch KUPO:0001121 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001430 urethra urothelial cell semapv:crossSpeciesExactMatch KUPO:0001124 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001431 kidney collecting duct principal cell semapv:crossSpeciesExactMatch KUPO:0001128 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001432 kidney collecting duct intercalated cell semapv:crossSpeciesExactMatch KUPO:0001129 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001433 epithelial cell of exocrine pancreas semapv:crossSpeciesExactMatch FMA:70986 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001509 semapv:crossSpeciesExactMatch FBbt:00048032 glycinergic neuron semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:1001509 semapv:crossSpeciesExactMatch ZFA:0009396 glycinergic neuron semapv:UnspecifiedMatching obo:zfa.owl
-CL:1001569 hippocampal interneuron semapv:crossSpeciesExactMatch FMA:84777 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001598 small intestine glandular cell semapv:crossSpeciesExactMatch FMA:86928 semapv:UnspecifiedMatching obo:cl.owl
-CL:1001611 cerebellar neuron semapv:crossSpeciesExactMatch FMA:84665 semapv:UnspecifiedMatching obo:cl.owl
-CL:2000002 decidual cell skos:narrowMatch NCIT:C32429 semapv:UnspecifiedMatching obo:cl.owl
-CL:2000019 semapv:crossSpeciesExactMatch FBbt:00006009 eye photoreceptor cell semapv:ManualMappingCuration obo:cl.owl obo:fbbt.owl 2024-07-12
-CL:2000032 peripheral nervous system neuron semapv:crossSpeciesExactMatch FMA:84664 semapv:UnspecifiedMatching obo:cl.owl
-CL:2000048 anterior horn motor neuron skos:narrowMatch NCIT:C12645 semapv:UnspecifiedMatching obo:cl.owl
-CL:4023120 cochlea auditory hair cell semapv:crossSpeciesExactMatch FMA:62364 semapv:UnspecifiedMatching obo:cl.owl
-CL:4030055 intermediate cell of urothelium semapv:crossSpeciesExactMatch FMA:84155 semapv:UnspecifiedMatching obo:cl.owl
-CL:4030056 umbrella cell of urothelium semapv:crossSpeciesExactMatch FMA:84149 semapv:UnspecifiedMatching obo:cl.owl
+# - ORCID:0000-0002-1373-1705
+# - ORCID:0000-0002-6095-8718
+#license: http://creativecommons.org/licenses/by/4.0/
+#subject_source: obo:cl.owl
+subject_id subject_label predicate_id object_id object_label mapping_justification object_source mapping_date
+CL:0000000 cell skos:broadMatch VHOG:0001533 semapv:UnspecifiedMatching
+CL:0000000 cell skos:exactMatch GO:0005623 semapv:UnspecifiedMatching
+CL:0000000 cell semapv:crossSpeciesExactMatch FBbt:00007002 cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000000 cell semapv:crossSpeciesExactMatch KUPO:0000002 semapv:UnspecifiedMatching
+CL:0000000 cell semapv:crossSpeciesExactMatch WBbt:0004017 semapv:UnspecifiedMatching
+CL:0000000 cell semapv:crossSpeciesExactMatch XAO:0003012 semapv:UnspecifiedMatching
+CL:0000000 cell semapv:crossSpeciesExactMatch ZFA:0009000 cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000000 cell semapv:crossSpeciesExactMatch FMA:68646 semapv:UnspecifiedMatching
+CL:0000006 neuronal receptor cell semapv:crossSpeciesExactMatch ZFA:0009001 receptor cell (sensu Animalia) semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000007 early embryonic cell (metazoa) semapv:crossSpeciesExactMatch ZFA:0009002 early embryonic cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000008 migratory cranial neural crest cell semapv:crossSpeciesExactMatch ZFA:0007091 migratory cranial neural crest cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000011 migratory trunk neural crest cell semapv:crossSpeciesExactMatch ZFA:0007095 migratory trunk neural crest cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000014 germ line stem cell semapv:crossSpeciesExactMatch FBbt:00004861 germline stem cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000014 germ line stem cell semapv:crossSpeciesExactMatch ZFA:0005956 germline stem cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000015 male germ cell skos:broadMatch VHOG:0001531 semapv:UnspecifiedMatching
+CL:0000015 male germ cell semapv:crossSpeciesExactMatch MA:0002765 semapv:UnspecifiedMatching
+CL:0000015 male germ cell semapv:crossSpeciesExactMatch FMA:72290 semapv:UnspecifiedMatching
+CL:0000016 male germ line stem cell semapv:crossSpeciesExactMatch FBbt:00004929 male germline stem cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000017 spermatocyte semapv:crossSpeciesExactMatch EMAPA:31484 semapv:UnspecifiedMatching
+CL:0000017 spermatocyte semapv:crossSpeciesExactMatch FBbt:00004936 spermatocyte semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000017 spermatocyte semapv:crossSpeciesExactMatch WBbt:0006799 semapv:UnspecifiedMatching
+CL:0000017 spermatocyte semapv:crossSpeciesExactMatch ZFA:0009005 spermatocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000017 spermatocyte semapv:crossSpeciesExactMatch FMA:84049 semapv:UnspecifiedMatching
+CL:0000018 spermatid semapv:crossSpeciesExactMatch EMAPA:31486 semapv:UnspecifiedMatching
+CL:0000018 spermatid semapv:crossSpeciesExactMatch FBbt:00004942 spermatid semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000018 spermatid semapv:crossSpeciesExactMatch WBbt:0006800 semapv:UnspecifiedMatching
+CL:0000018 spermatid semapv:crossSpeciesExactMatch ZFA:0005769 spermatid semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000018 spermatid semapv:crossSpeciesExactMatch FMA:72294 semapv:UnspecifiedMatching
+CL:0000019 sperm semapv:crossSpeciesExactMatch FBbt:00004954 spermatozoon semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000019 sperm semapv:crossSpeciesExactMatch WBbt:0006798 semapv:UnspecifiedMatching
+CL:0000019 sperm semapv:crossSpeciesExactMatch ZFA:0009006 sperm semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000019 sperm semapv:crossSpeciesExactMatch FMA:67338 semapv:UnspecifiedMatching
+CL:0000020 spermatogonium semapv:crossSpeciesExactMatch EMAPA:31482 semapv:UnspecifiedMatching
+CL:0000020 spermatogonium semapv:crossSpeciesExactMatch FBbt:00004934 primary gonial cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000020 spermatogonium semapv:crossSpeciesExactMatch FBbt:00004935 spermatogonium semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000020 spermatogonium semapv:crossSpeciesExactMatch ZFA:0009007 spermatogonium semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000020 spermatogonium semapv:crossSpeciesExactMatch FMA:72291 semapv:UnspecifiedMatching
+CL:0000021 female germ cell skos:broadMatch VHOG:0001530 semapv:UnspecifiedMatching
+CL:0000021 female germ cell semapv:crossSpeciesExactMatch MA:0000388 semapv:UnspecifiedMatching
+CL:0000022 female germ line stem cell semapv:crossSpeciesExactMatch FBbt:00004873 female germline stem cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000023 oocyte semapv:crossSpeciesExactMatch FBbt:00004886 oocyte semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000023 oocyte semapv:crossSpeciesExactMatch WBbt:0006797 semapv:UnspecifiedMatching
+CL:0000023 oocyte semapv:crossSpeciesExactMatch ZFA:0001109 oocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000023 oocyte semapv:crossSpeciesExactMatch FMA:18644 semapv:UnspecifiedMatching
+CL:0000024 oogonial cell semapv:crossSpeciesExactMatch ZFA:0005878 oogonia semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000024 oogonial cell semapv:crossSpeciesExactMatch FMA:83673 semapv:UnspecifiedMatching
+CL:0000025 egg cell semapv:crossSpeciesExactMatch FBbt:00057012 female germline cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000025 egg cell semapv:crossSpeciesExactMatch ZFA:0001570 unfertilized egg semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000025 egg cell semapv:crossSpeciesExactMatch FMA:67343 semapv:UnspecifiedMatching
+CL:0000026 invertebrate nurse cell semapv:crossSpeciesExactMatch FBbt:00004878 nurse cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000029 neural crest derived neuron semapv:crossSpeciesExactMatch ZFA:0009009 neuron neural crest derived semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000030 glioblast semapv:crossSpeciesExactMatch ZFA:0009010 glioblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000031 neuroblast (sensu Vertebrata) semapv:crossSpeciesExactMatch ZFA:0009011 neuroblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000031 neuroblast (sensu Vertebrata) semapv:crossSpeciesExactMatch FMA:70563 semapv:UnspecifiedMatching
+CL:0000032 neuroplacodal cell semapv:crossSpeciesExactMatch ZFA:0009012 neuroplacodal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000034 stem cell semapv:crossSpeciesExactMatch ZFA:0005957 stem cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000034 stem cell semapv:crossSpeciesExactMatch FMA:63368 semapv:UnspecifiedMatching
+CL:0000035 single fate stem cell semapv:crossSpeciesExactMatch ZFA:0009013 single fate stem cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000035 single fate stem cell semapv:crossSpeciesExactMatch FMA:70569 semapv:UnspecifiedMatching
+CL:0000037 hematopoietic stem cell skos:broadMatch VHOG:0001485 semapv:UnspecifiedMatching
+CL:0000037 hematopoietic stem cell semapv:crossSpeciesExactMatch ZFA:0009014 hematopoietic stem cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000037 hematopoietic stem cell semapv:crossSpeciesExactMatch FMA:86475 semapv:UnspecifiedMatching
+CL:0000038 erythroid progenitor cell semapv:crossSpeciesExactMatch ZFA:0009015 erythroid progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000039 germ line cell semapv:crossSpeciesExactMatch ZFA:0009016 germ line cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000040 monoblast semapv:crossSpeciesExactMatch ZFA:0009017 monoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000040 monoblast semapv:crossSpeciesExactMatch FMA:83553 semapv:UnspecifiedMatching
+CL:0000042 neutrophilic myeloblast semapv:crossSpeciesExactMatch ZFA:0009018 neutrophilic myeloblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000047 neural stem cell semapv:crossSpeciesExactMatch ZFA:0009019 neuronal stem cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000047 neural stem cell semapv:crossSpeciesExactMatch FMA:86684 semapv:UnspecifiedMatching
+CL:0000048 multi fate stem cell semapv:crossSpeciesExactMatch ZFA:0009020 multi fate stem cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000048 multi fate stem cell semapv:crossSpeciesExactMatch FMA:84789 semapv:UnspecifiedMatching
+CL:0000049 common myeloid progenitor semapv:crossSpeciesExactMatch ZFA:0009021 common myeloid progenitor semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000050 megakaryocyte-erythroid progenitor cell semapv:crossSpeciesExactMatch ZFA:0009022 megakaryocyte erythroid progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000051 common lymphoid progenitor semapv:crossSpeciesExactMatch ZFA:0009023 common lymphoid progenitor semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000052 totipotent stem cell semapv:crossSpeciesExactMatch ZFA:0009024 totipotent stem cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000052 totipotent stem cell semapv:crossSpeciesExactMatch FMA:84790 semapv:UnspecifiedMatching
+CL:0000055 non-terminally differentiated cell semapv:crossSpeciesExactMatch FMA:84782 semapv:UnspecifiedMatching
+CL:0000056 myoblast skos:broadMatch VHOG:0001529 semapv:UnspecifiedMatching
+CL:0000056 myoblast semapv:crossSpeciesExactMatch FBbt:00005083 myoblast semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000056 myoblast semapv:crossSpeciesExactMatch ZFA:0009025 myoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000056 myoblast semapv:crossSpeciesExactMatch FMA:70335 semapv:UnspecifiedMatching
+CL:0000057 fibroblast skos:broadMatch VHOG:0001482 semapv:UnspecifiedMatching
+CL:0000057 fibroblast skos:narrowMatch NCIT:C12482 semapv:UnspecifiedMatching
+CL:0000057 fibroblast semapv:crossSpeciesExactMatch ZFA:0009026 fibroblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000057 fibroblast semapv:crossSpeciesExactMatch FMA:63877 semapv:UnspecifiedMatching
+CL:0000058 chondroblast semapv:crossSpeciesExactMatch ZFA:0009027 chondroblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000058 chondroblast semapv:crossSpeciesExactMatch FMA:66783 semapv:UnspecifiedMatching
+CL:0000059 ameloblast semapv:crossSpeciesExactMatch FMA:70576 semapv:UnspecifiedMatching
+CL:0000060 odontoblast semapv:crossSpeciesExactMatch ZFA:0009029 odontoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000060 odontoblast semapv:crossSpeciesExactMatch FMA:62999 semapv:UnspecifiedMatching
+CL:0000061 cementoblast semapv:crossSpeciesExactMatch ZFA:0009030 cementoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000061 cementoblast semapv:crossSpeciesExactMatch FMA:63002 semapv:UnspecifiedMatching
+CL:0000062 osteoblast semapv:crossSpeciesExactMatch ZFA:0009031 osteoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000062 osteoblast semapv:crossSpeciesExactMatch FMA:66780 semapv:UnspecifiedMatching
+CL:0000064 ciliated cell skos:broadMatch VHOG:0001532 semapv:UnspecifiedMatching
+CL:0000064 ciliated cell semapv:crossSpeciesExactMatch XAO:0000031 semapv:UnspecifiedMatching
+CL:0000064 ciliated cell semapv:crossSpeciesExactMatch ZFA:0009032 ciliated cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000065 ependymal cell semapv:crossSpeciesExactMatch ZFA:0009033 ependymal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000065 ependymal cell semapv:crossSpeciesExactMatch FMA:70550 semapv:UnspecifiedMatching
+CL:0000066 epithelial cell skos:exactMatch CARO:0000077 semapv:UnspecifiedMatching
+CL:0000066 epithelial cell semapv:crossSpeciesExactMatch FBbt:00000124 epithelial cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000066 epithelial cell semapv:crossSpeciesExactMatch WBbt:0003672 semapv:UnspecifiedMatching
+CL:0000066 epithelial cell semapv:crossSpeciesExactMatch ZFA:0009034 epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000066 epithelial cell semapv:crossSpeciesExactMatch FMA:66768 semapv:UnspecifiedMatching
+CL:0000067 ciliated epithelial cell semapv:crossSpeciesExactMatch ZFA:0009035 ciliated epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000067 ciliated epithelial cell semapv:crossSpeciesExactMatch FMA:70605 semapv:UnspecifiedMatching
+CL:0000068 duct epithelial cell semapv:crossSpeciesExactMatch ZFA:0009372 duct epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000071 blood vessel endothelial cell semapv:crossSpeciesExactMatch ZFA:0009036 blood vessel endothelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000075 columnar/cuboidal epithelial cell semapv:crossSpeciesExactMatch ZFA:0009038 columnar/cuboidal epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000076 squamous epithelial cell semapv:crossSpeciesExactMatch ZFA:0009039 squamous epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000077 mesothelial cell semapv:crossSpeciesExactMatch ZFA:0009040 mesothelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000077 mesothelial cell semapv:crossSpeciesExactMatch FMA:66773 semapv:UnspecifiedMatching
+CL:0000078 peridermal cell semapv:crossSpeciesExactMatch ZFA:0009041 peridermal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000079 stratified epithelial cell semapv:crossSpeciesExactMatch ZFA:0009042 stratified epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000080 circulating cell semapv:crossSpeciesExactMatch ZFA:0009043 circulating cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000081 blood cell semapv:crossSpeciesExactMatch ZFA:0009044 blood cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000081 blood cell semapv:crossSpeciesExactMatch FMA:62844 semapv:UnspecifiedMatching
+CL:0000083 epithelial cell of pancreas semapv:crossSpeciesExactMatch ZFA:0009045 epithelial cell of pancreas semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000084 T cell skos:broadMatch VHOG:0001479 semapv:UnspecifiedMatching
+CL:0000084 T cell semapv:crossSpeciesExactMatch ZFA:0009046 T cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000084 T cell semapv:crossSpeciesExactMatch FMA:62870 semapv:UnspecifiedMatching
+CL:0000091 Kupffer cell semapv:crossSpeciesExactMatch FMA:14656 semapv:UnspecifiedMatching
+CL:0000092 osteoclast semapv:crossSpeciesExactMatch ZFA:0009047 osteoclast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000092 osteoclast semapv:crossSpeciesExactMatch FMA:66781 semapv:UnspecifiedMatching
+CL:0000094 granulocyte semapv:crossSpeciesExactMatch ZFA:0009048 granulocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000094 granulocyte semapv:crossSpeciesExactMatch FMA:62854 semapv:UnspecifiedMatching
+CL:0000096 mature neutrophil semapv:crossSpeciesExactMatch ZFA:0009049 mature neutrophil semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000097 mast cell semapv:crossSpeciesExactMatch FMA:66784 semapv:UnspecifiedMatching
+CL:0000098 sensory epithelial cell semapv:crossSpeciesExactMatch ZFA:0009050 sensory epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000099 interneuron semapv:crossSpeciesExactMatch FBbt:00005125 interneuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000099 interneuron semapv:crossSpeciesExactMatch WBbt:0005113 semapv:UnspecifiedMatching
+CL:0000099 interneuron semapv:crossSpeciesExactMatch ZFA:0009051 interneuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000099 interneuron semapv:crossSpeciesExactMatch FMA:67313 semapv:UnspecifiedMatching
+CL:0000100 motor neuron semapv:crossSpeciesExactMatch FBbt:00005123 motor neuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000100 motor neuron semapv:crossSpeciesExactMatch WBbt:0005409 semapv:UnspecifiedMatching
+CL:0000100 motor neuron semapv:crossSpeciesExactMatch ZFA:0009052 motor neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000100 motor neuron semapv:crossSpeciesExactMatch FMA:83617 semapv:UnspecifiedMatching
+CL:0000101 sensory neuron semapv:crossSpeciesExactMatch FBbt:00005124 sensory neuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000101 sensory neuron semapv:crossSpeciesExactMatch WBbt:0005759 semapv:UnspecifiedMatching
+CL:0000101 sensory neuron semapv:crossSpeciesExactMatch ZFA:0009053 sensory neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000101 sensory neuron semapv:crossSpeciesExactMatch FMA:84649 semapv:UnspecifiedMatching
+CL:0000102 polymodal neuron semapv:crossSpeciesExactMatch ZFA:0009054 polymodal neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000103 bipolar neuron semapv:crossSpeciesExactMatch ZFA:0009055 bipolar neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000103 bipolar neuron semapv:crossSpeciesExactMatch FMA:67282 semapv:UnspecifiedMatching
+CL:0000104 multipolar neuron semapv:crossSpeciesExactMatch ZFA:0009056 multipolar neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000104 multipolar neuron semapv:crossSpeciesExactMatch FMA:67287 semapv:UnspecifiedMatching
+CL:0000105 pseudounipolar neuron semapv:crossSpeciesExactMatch ZFA:0009057 pseudounipolar neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000105 pseudounipolar neuron semapv:crossSpeciesExactMatch FMA:67305 semapv:UnspecifiedMatching
+CL:0000106 unipolar neuron semapv:crossSpeciesExactMatch ZFA:0009058 unipolar neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000106 unipolar neuron semapv:crossSpeciesExactMatch FMA:67278 semapv:UnspecifiedMatching
+CL:0000107 autonomic neuron semapv:crossSpeciesExactMatch ZFA:0009059 autonomic neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000107 autonomic neuron semapv:crossSpeciesExactMatch FMA:80121 semapv:UnspecifiedMatching
+CL:0000108 cholinergic neuron semapv:crossSpeciesExactMatch FBbt:00007173 cholinergic neuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000108 cholinergic neuron semapv:crossSpeciesExactMatch WBbt:0006840 semapv:UnspecifiedMatching
+CL:0000108 cholinergic neuron semapv:crossSpeciesExactMatch ZFA:0009060 cholinergic neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000108 cholinergic neuron semapv:crossSpeciesExactMatch FMA:84796 semapv:UnspecifiedMatching
+CL:0000109 adrenergic neuron semapv:crossSpeciesExactMatch ZFA:0009061 adrenergic neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000110 peptidergic neuron semapv:crossSpeciesExactMatch FBbt:00004101 peptidergic neuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000110 peptidergic neuron semapv:crossSpeciesExactMatch ZFA:0009062 peptidergic neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000113 mononuclear phagocyte semapv:crossSpeciesExactMatch ZFA:0009064 mononuclear phagocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000114 surface ectodermal cell semapv:crossSpeciesExactMatch FMA:72552 semapv:UnspecifiedMatching
+CL:0000115 endothelial cell semapv:crossSpeciesExactMatch ZFA:0009065 endothelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000115 endothelial cell semapv:crossSpeciesExactMatch FMA:66772 semapv:UnspecifiedMatching
+CL:0000116 pioneer neuron semapv:crossSpeciesExactMatch FBbt:00005128 pioneer neuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000116 pioneer neuron semapv:crossSpeciesExactMatch ZFA:0009066 pioneer neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000117 CNS neuron (sensu Vertebrata) semapv:crossSpeciesExactMatch ZFA:0009067 CNS neuron (sensu Vertebrata) semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000118 basket cell semapv:crossSpeciesExactMatch ZFA:0009068 basket cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000119 cerebellar Golgi cell semapv:crossSpeciesExactMatch ZFA:0009069 Golgi cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000120 granule cell semapv:crossSpeciesExactMatch ZFA:0009070 granule cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000121 Purkinje cell semapv:crossSpeciesExactMatch ZFA:0009071 Purkinje cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000121 Purkinje cell semapv:crossSpeciesExactMatch FMA:67969 semapv:UnspecifiedMatching
+CL:0000122 stellate neuron semapv:crossSpeciesExactMatch ZFA:0009072 stellate cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000125 glial cell semapv:crossSpeciesExactMatch FBbt:00005144 glial cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000125 glial cell semapv:crossSpeciesExactMatch ZFA:0009073 glial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000125 glial cell semapv:crossSpeciesExactMatch FMA:54536 semapv:UnspecifiedMatching
+CL:0000126 macroglial cell semapv:crossSpeciesExactMatch ZFA:0009074 macroglial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000126 macroglial cell semapv:crossSpeciesExactMatch FMA:54538 semapv:UnspecifiedMatching
+CL:0000127 astrocyte semapv:crossSpeciesExactMatch ZFA:0009075 astrocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000127 astrocyte semapv:crossSpeciesExactMatch FMA:54537 semapv:UnspecifiedMatching
+CL:0000128 oligodendrocyte semapv:crossSpeciesExactMatch ZFA:0009076 oligodendrocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000128 oligodendrocyte semapv:crossSpeciesExactMatch FMA:54540 semapv:UnspecifiedMatching
+CL:0000129 microglial cell semapv:crossSpeciesExactMatch ZFA:0009077 microglial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000129 microglial cell semapv:crossSpeciesExactMatch FMA:54539 semapv:UnspecifiedMatching
+CL:0000131 gut endothelial cell semapv:crossSpeciesExactMatch ZFA:0009078 gut endothelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000132 corneal endothelial cell semapv:crossSpeciesExactMatch ZFA:0009079 corneal endothelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000132 corneal endothelial cell semapv:crossSpeciesExactMatch FMA:70614 semapv:UnspecifiedMatching
+CL:0000133 neurectodermal cell semapv:crossSpeciesExactMatch ZFA:0009080 neurectodermal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000134 mesenchymal stem cell semapv:crossSpeciesExactMatch ZFA:0009081 mesenchymal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000134 mesenchymal stem cell semapv:crossSpeciesExactMatch FMA:70546 semapv:UnspecifiedMatching
+CL:0000135 fibrocyte semapv:crossSpeciesExactMatch FMA:63879 semapv:UnspecifiedMatching
+CL:0000136 adipocyte semapv:crossSpeciesExactMatch ZFA:0009082 fat cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000136 adipocyte semapv:crossSpeciesExactMatch FMA:63880 semapv:UnspecifiedMatching
+CL:0000137 osteocyte skos:exactMatch VSAO:0000124 semapv:UnspecifiedMatching
+CL:0000137 osteocyte semapv:crossSpeciesExactMatch ZFA:0009083 osteocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000137 osteocyte semapv:crossSpeciesExactMatch FMA:66779 semapv:UnspecifiedMatching
+CL:0000138 chondrocyte semapv:crossSpeciesExactMatch ZFA:0009084 chondrocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000138 chondrocyte semapv:crossSpeciesExactMatch FMA:66782 semapv:UnspecifiedMatching
+CL:0000140 odontocyte semapv:crossSpeciesExactMatch ZFA:0009086 odontocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000141 cementocyte semapv:crossSpeciesExactMatch ZFA:0009087 cementocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000141 cementocyte semapv:crossSpeciesExactMatch FMA:63003 semapv:UnspecifiedMatching
+CL:0000142 hyalocyte semapv:crossSpeciesExactMatch FMA:70620 semapv:UnspecifiedMatching
+CL:0000145 professional antigen presenting cell semapv:crossSpeciesExactMatch ZFA:0009088 professional antigen presenting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000146 simple columnar epithelial cell semapv:crossSpeciesExactMatch ZFA:0009089 simple columnar epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000147 pigment cell skos:broadMatch VHOG:0001678 semapv:UnspecifiedMatching
+CL:0000147 pigment cell semapv:crossSpeciesExactMatch ZFA:0009090 pigment cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000148 melanocyte skos:broadMatch VHOG:0001679 semapv:UnspecifiedMatching
+CL:0000148 melanocyte semapv:crossSpeciesExactMatch ZFA:0009091 melanocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000148 melanocyte semapv:crossSpeciesExactMatch FMA:70545 semapv:UnspecifiedMatching
+CL:0000150 glandular secretory epithelial cell semapv:crossSpeciesExactMatch FMA:86494 semapv:UnspecifiedMatching
+CL:0000151 secretory cell semapv:crossSpeciesExactMatch FMA:86916 semapv:UnspecifiedMatching
+CL:0000152 exocrine cell semapv:crossSpeciesExactMatch ZFA:0009092 exocrine cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000152 exocrine cell semapv:crossSpeciesExactMatch FMA:16014 semapv:UnspecifiedMatching
+CL:0000153 glycosaminoglycan secreting cell semapv:crossSpeciesExactMatch ZFA:0009093 GAG secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000155 peptic cell semapv:crossSpeciesExactMatch FMA:62902 semapv:UnspecifiedMatching
+CL:0000158 club cell semapv:crossSpeciesExactMatch FMA:14119 semapv:UnspecifiedMatching
+CL:0000160 goblet cell semapv:crossSpeciesExactMatch ZFA:0009094 goblet cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000160 goblet cell semapv:crossSpeciesExactMatch FMA:13148 semapv:UnspecifiedMatching
+CL:0000162 parietal cell semapv:crossSpeciesExactMatch FMA:62901 semapv:UnspecifiedMatching
+CL:0000163 endocrine cell semapv:crossSpeciesExactMatch ZFA:0009096 endocrine cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000163 endocrine cell semapv:crossSpeciesExactMatch FMA:83809 semapv:UnspecifiedMatching
+CL:0000164 enteroendocrine cell semapv:crossSpeciesExactMatch ZFA:0009097 enteroendocrine cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000164 enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62930 semapv:UnspecifiedMatching
+CL:0000165 neuroendocrine cell semapv:crossSpeciesExactMatch FBbt:00005130 neurosecretory neuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000165 neuroendocrine cell semapv:crossSpeciesExactMatch ZFA:0009098 neuroendocrine cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000165 neuroendocrine cell semapv:crossSpeciesExactMatch FMA:83810 semapv:UnspecifiedMatching
+CL:0000166 chromaffin cell semapv:crossSpeciesExactMatch ZFA:0009099 chromaffin cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000166 chromaffin cell semapv:crossSpeciesExactMatch FMA:69263 semapv:UnspecifiedMatching
+CL:0000167 peptide hormone secreting cell semapv:crossSpeciesExactMatch ZFA:0009100 peptide hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000168 insulin secreting cell semapv:crossSpeciesExactMatch ZFA:0009101 insulin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000169 type B pancreatic cell skos:narrowMatch EV:0200009 semapv:UnspecifiedMatching
+CL:0000169 type B pancreatic cell semapv:crossSpeciesExactMatch MA:0002419 semapv:UnspecifiedMatching
+CL:0000169 type B pancreatic cell semapv:crossSpeciesExactMatch ZFA:0009102 pancreatic B cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000169 type B pancreatic cell semapv:crossSpeciesExactMatch FMA:70586 semapv:UnspecifiedMatching
+CL:0000170 glucagon secreting cell semapv:crossSpeciesExactMatch ZFA:0009103 glucagon secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000170 glucagon secreting cell semapv:crossSpeciesExactMatch FMA:84045 semapv:UnspecifiedMatching
+CL:0000171 pancreatic A cell semapv:crossSpeciesExactMatch ZFA:0009104 pancreatic A cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000171 pancreatic A cell semapv:crossSpeciesExactMatch FMA:70585 semapv:UnspecifiedMatching
+CL:0000172 somatostatin secreting cell semapv:crossSpeciesExactMatch ZFA:0009105 somatostatin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000173 pancreatic D cell semapv:crossSpeciesExactMatch ZFA:0005743 pancreatic D cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000173 pancreatic D cell semapv:crossSpeciesExactMatch FMA:70587 semapv:UnspecifiedMatching
+CL:0000174 steroid hormone secreting cell semapv:crossSpeciesExactMatch ZFA:0009106 steroid hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000175 luteal cell semapv:crossSpeciesExactMatch FMA:18688 semapv:UnspecifiedMatching
+CL:0000177 testosterone secreting cell semapv:crossSpeciesExactMatch ZFA:0009107 testosterone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000178 Leydig cell semapv:crossSpeciesExactMatch EMAPA:29655 semapv:UnspecifiedMatching
+CL:0000178 Leydig cell semapv:crossSpeciesExactMatch ZFA:0009108 Leydig cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000178 Leydig cell semapv:crossSpeciesExactMatch FMA:72297 semapv:UnspecifiedMatching
+CL:0000179 progesterone secreting cell semapv:crossSpeciesExactMatch ZFA:0009109 progesterone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000180 estradiol secreting cell semapv:crossSpeciesExactMatch ZFA:0009110 estradiol secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000182 hepatocyte semapv:crossSpeciesExactMatch ZFA:0009111 hepatocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000182 hepatocyte semapv:crossSpeciesExactMatch FMA:14515 semapv:UnspecifiedMatching
+CL:0000185 myoepithelial cell semapv:crossSpeciesExactMatch ZFA:0009113 myoepithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000185 myoepithelial cell semapv:crossSpeciesExactMatch FMA:67799 semapv:UnspecifiedMatching
+CL:0000187 muscle cell semapv:crossSpeciesExactMatch FBbt:00005074 muscle cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000187 muscle cell semapv:crossSpeciesExactMatch WBbt:0003675 semapv:UnspecifiedMatching
+CL:0000187 muscle cell semapv:crossSpeciesExactMatch ZFA:0009114 muscle cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000187 muscle cell semapv:crossSpeciesExactMatch FMA:67328 semapv:UnspecifiedMatching
+CL:0000188 cell of skeletal muscle semapv:crossSpeciesExactMatch ZFA:0009115 skeletal muscle cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000188 cell of skeletal muscle semapv:crossSpeciesExactMatch FMA:9727 semapv:UnspecifiedMatching
+CL:0000189 slow muscle cell semapv:crossSpeciesExactMatch ZFA:0009116 slow muscle cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000190 fast muscle cell semapv:crossSpeciesExactMatch ZFA:0009117 fast muscle cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000192 smooth muscle cell semapv:crossSpeciesExactMatch ZFA:0009118 smooth muscle cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000192 smooth muscle cell semapv:crossSpeciesExactMatch FMA:14072 semapv:UnspecifiedMatching
+CL:0000196 insect flight muscle cell semapv:crossSpeciesExactMatch FBbt:00003360 flight muscle cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000198 pain receptor cell semapv:crossSpeciesExactMatch ZFA:0009119 pain receptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000199 mechanoreceptor cell semapv:crossSpeciesExactMatch ZFA:0009120 mechanoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000202 auditory hair cell semapv:crossSpeciesExactMatch ZFA:0009121 auditory receptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000205 thermoreceptor cell semapv:crossSpeciesExactMatch ZFA:0009123 thermoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000206 chemoreceptor cell semapv:crossSpeciesExactMatch ZFA:0009124 chemoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000207 olfactory receptor cell semapv:crossSpeciesExactMatch ZFA:0009125 olfactory receptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000207 olfactory receptor cell semapv:crossSpeciesExactMatch FMA:67860 semapv:UnspecifiedMatching
+CL:0000209 taste receptor cell semapv:crossSpeciesExactMatch ZFA:0009126 taste receptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000209 taste receptor cell semapv:crossSpeciesExactMatch FMA:67910 semapv:UnspecifiedMatching
+CL:0000210 photoreceptor cell semapv:crossSpeciesExactMatch FBbt:00004211 photoreceptor cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000210 photoreceptor cell semapv:crossSpeciesExactMatch ZFA:0009127 photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000210 photoreceptor cell semapv:crossSpeciesExactMatch FMA:86740 semapv:UnspecifiedMatching
+CL:0000211 electrically active cell semapv:crossSpeciesExactMatch ZFA:0009128 electrically active cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000212 absorptive cell semapv:crossSpeciesExactMatch ZFA:0009129 absorptive cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000213 lining cell semapv:crossSpeciesExactMatch ZFA:0009130 lining cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000214 synovial cell semapv:crossSpeciesExactMatch ZFA:0009131 synovial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000215 barrier cell semapv:crossSpeciesExactMatch ZFA:0009132 barrier cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000216 Sertoli cell skos:broadMatch VHOG:0001348 semapv:UnspecifiedMatching
+CL:0000216 Sertoli cell semapv:crossSpeciesExactMatch ZFA:0009133 Sertoli cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000216 Sertoli cell semapv:crossSpeciesExactMatch FMA:72298 semapv:UnspecifiedMatching
+CL:0000217 insulating cell semapv:crossSpeciesExactMatch ZFA:0009134 insulating cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000218 myelinating Schwann cell semapv:crossSpeciesExactMatch ZFA:0009135 myelinating Schwann cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000218 myelinating Schwann cell semapv:crossSpeciesExactMatch FMA:62121 semapv:UnspecifiedMatching
+CL:0000219 motile cell semapv:crossSpeciesExactMatch ZFA:0009136 motile cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000221 ectodermal cell semapv:crossSpeciesExactMatch ZFA:0009137 ectodermal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000221 ectodermal cell semapv:crossSpeciesExactMatch FMA:72549 semapv:UnspecifiedMatching
+CL:0000222 mesodermal cell semapv:crossSpeciesExactMatch ZFA:0009138 mesodermal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000222 mesodermal cell semapv:crossSpeciesExactMatch FMA:72554 semapv:UnspecifiedMatching
+CL:0000223 endodermal cell semapv:crossSpeciesExactMatch ZFA:0009139 endodermal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000223 endodermal cell semapv:crossSpeciesExactMatch FMA:72555 semapv:UnspecifiedMatching
+CL:0000225 anucleate cell semapv:crossSpeciesExactMatch FMA:68647 semapv:UnspecifiedMatching
+CL:0000232 erythrocyte semapv:crossSpeciesExactMatch FMA:81100 semapv:UnspecifiedMatching
+CL:0000233 platelet semapv:crossSpeciesExactMatch FMA:62851 semapv:UnspecifiedMatching
+CL:0000234 phagocyte semapv:crossSpeciesExactMatch ZFA:0009140 phagocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000234 phagocyte semapv:crossSpeciesExactMatch FMA:83806 semapv:UnspecifiedMatching
+CL:0000235 macrophage semapv:crossSpeciesExactMatch ZFA:0009141 macrophage semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000235 macrophage semapv:crossSpeciesExactMatch FMA:63261 semapv:UnspecifiedMatching
+CL:0000235 macrophage semapv:crossSpeciesExactMatch FMA:83585 semapv:UnspecifiedMatching
+CL:0000236 B cell skos:broadMatch VHOG:0001480 semapv:UnspecifiedMatching
+CL:0000236 B cell semapv:crossSpeciesExactMatch ZFA:0009142 B cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000236 B cell semapv:crossSpeciesExactMatch FMA:62869 semapv:UnspecifiedMatching
+CL:0000239 brush border epithelial cell semapv:crossSpeciesExactMatch ZFA:0009143 brush border epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000240 stratified squamous epithelial cell semapv:crossSpeciesExactMatch ZFA:0009144 stratified squamous epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000241 stratified cuboidal epithelial cell semapv:crossSpeciesExactMatch ZFA:0009145 stratified cuboidal epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000242 Merkel cell semapv:crossSpeciesExactMatch ZFA:0009146 Merkel cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000242 Merkel cell semapv:crossSpeciesExactMatch FMA:70548 semapv:UnspecifiedMatching
+CL:0000244 transitional epithelial cell semapv:crossSpeciesExactMatch ZFA:0009148 transitional epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000244 transitional epithelial cell semapv:crossSpeciesExactMatch FMA:66778 semapv:UnspecifiedMatching
+CL:0000246 Mauthner neuron semapv:crossSpeciesExactMatch ZFA:0009149 Mauthner neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000247 Rohon-Beard neuron skos:broadMatch VHOG:0001484 semapv:UnspecifiedMatching
+CL:0000247 Rohon-Beard neuron semapv:crossSpeciesExactMatch AAO:0010316 semapv:UnspecifiedMatching
+CL:0000247 Rohon-Beard neuron semapv:crossSpeciesExactMatch ZFA:0009150 semapv:UnspecifiedMatching
+CL:0000247 Rohon-Beard neuron semapv:crossSpeciesExactMatch ZFA:0009150 Rohon-Beard neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000249 hatching gland cell semapv:crossSpeciesExactMatch ZFA:0009151 hatching gland cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000251 extramedullary cell semapv:crossSpeciesExactMatch ZFA:0009152 extramedullary cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000253 eurydendroid cell semapv:crossSpeciesExactMatch ZFA:0009153 eurydendroid cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000287 eye photoreceptor cell semapv:crossSpeciesExactMatch ZFA:0009154 eye photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000293 structural cell semapv:crossSpeciesExactMatch ZFA:0005745 structural cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000295 somatotropin secreting cell semapv:crossSpeciesExactMatch ZFA:0009155 somatotropin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000300 gamete semapv:crossSpeciesExactMatch FBbt:00005412 gamete semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000300 gamete semapv:crossSpeciesExactMatch ZFA:0009156 gamete semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000300 gamete semapv:crossSpeciesExactMatch FMA:18649 semapv:UnspecifiedMatching
+CL:0000301 pole cell semapv:crossSpeciesExactMatch FBbt:00000092 primordial germ cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000307 tracheal epithelial cell semapv:crossSpeciesExactMatch FMA:74793 semapv:UnspecifiedMatching
+CL:0000311 keratin accumulating cell semapv:crossSpeciesExactMatch ZFA:0009157 keratin accumulating cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000312 keratinocyte semapv:crossSpeciesExactMatch ZFA:0009158 keratinocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000312 keratinocyte semapv:crossSpeciesExactMatch FMA:62879 semapv:UnspecifiedMatching
+CL:0000313 serous secreting cell semapv:crossSpeciesExactMatch FMA:62511 semapv:UnspecifiedMatching
+CL:0000319 mucus secreting cell semapv:crossSpeciesExactMatch ZFA:0009159 mucus secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000322 pulmonary alveolar epithelial cell semapv:crossSpeciesExactMatch FMA:62499 semapv:UnspecifiedMatching
+CL:0000327 extracellular matrix secreting cell semapv:crossSpeciesExactMatch ZFA:0009162 extracellular matrix secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000329 oxygen accumulating cell semapv:crossSpeciesExactMatch ZFA:0009164 oxygen accumulating cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000333 migratory neural crest cell semapv:crossSpeciesExactMatch ZFA:0007086 migratory neural crest cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000333 migratory neural crest cell semapv:crossSpeciesExactMatch FMA:86667 semapv:UnspecifiedMatching
+CL:0000335 mesenchyme condensation cell semapv:crossSpeciesExactMatch ZFA:0009166 mesenchyme condensation cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000336 adrenal medulla chromaffin cell semapv:crossSpeciesExactMatch ZFA:0009167 adrenal medulla cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000336 adrenal medulla chromaffin cell semapv:crossSpeciesExactMatch FMA:69262 semapv:UnspecifiedMatching
+CL:0000338 neuroblast (sensu Nematoda and Protostomia) semapv:crossSpeciesExactMatch FBbt:00005146 neuroblast semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000339 glioblast (sensu Vertebrata) semapv:crossSpeciesExactMatch ZFA:0009169 glioblast (sensu Vertebrata) semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000339 glioblast (sensu Vertebrata) semapv:crossSpeciesExactMatch FMA:70564 semapv:UnspecifiedMatching
+CL:0000340 glioblast (sensu Nematoda and Protostomia) semapv:crossSpeciesExactMatch FBbt:00005145 glioblast semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000342 pigment cell (sensu Vertebrata) semapv:crossSpeciesExactMatch ZFA:0009170 pigment cell (sensu Vertebrata) semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000343 visual pigment cell (sensu Vertebrata) semapv:crossSpeciesExactMatch ZFA:0009171 visual pigment cell (sensu Vertebrata) semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000343 visual pigment cell (sensu Vertebrata) semapv:crossSpeciesExactMatch FMA:63846 semapv:UnspecifiedMatching
+CL:0000345 dental papilla cell semapv:crossSpeciesExactMatch ZFA:0009173 dental papilla cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000347 scleral cell semapv:crossSpeciesExactMatch ZFA:0009174 scleral cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000348 choroidal cell of the eye semapv:crossSpeciesExactMatch ZFA:0009175 choroidal cell of the eye semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000349 extraembryonic cell semapv:crossSpeciesExactMatch ZFA:0009176 extraembryonic cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000351 trophoblast cell semapv:crossSpeciesExactMatch FMA:83028 semapv:UnspecifiedMatching
+CL:0000353 blastoderm cell semapv:crossSpeciesExactMatch ZFA:0009177 blastoderm cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000353 blastoderm cell semapv:crossSpeciesExactMatch FMA:72551 semapv:UnspecifiedMatching
+CL:0000354 blastemal cell semapv:crossSpeciesExactMatch ZFA:0009178 blastemal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000355 multi-potent skeletal muscle stem cell semapv:crossSpeciesExactMatch ZFA:0009179 muscle stem cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000355 multi-potent skeletal muscle stem cell semapv:crossSpeciesExactMatch FMA:86767 semapv:UnspecifiedMatching
+CL:0000357 stratified epithelial stem cell semapv:crossSpeciesExactMatch ZFA:0009180 stratified epithelial stem cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000359 vascular associated smooth muscle cell semapv:crossSpeciesExactMatch ZFA:0009181 vascular associated smooth muscle cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000361 gastrula cell semapv:crossSpeciesExactMatch ZFA:0009182 gastrula cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000362 epidermal cell semapv:crossSpeciesExactMatch ZFA:0009183 epidermal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000362 epidermal cell semapv:crossSpeciesExactMatch FMA:62411 semapv:UnspecifiedMatching
+CL:0000365 animal zygote semapv:crossSpeciesExactMatch EHDAA2:0004546 semapv:UnspecifiedMatching
+CL:0000365 animal zygote semapv:crossSpeciesExactMatch FMA:72395 semapv:UnspecifiedMatching
+CL:0000372 tormogen cell semapv:crossSpeciesExactMatch FBbt:00005171 tormogen cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000373 histoblast semapv:crossSpeciesExactMatch FBbt:00001789 histoblast semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000374 trichogen cell semapv:crossSpeciesExactMatch FBbt:00005169 trichogen cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000379 sensory processing neuron semapv:crossSpeciesExactMatch ZFA:0009185 sensory processing neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000380 thecogen cell semapv:crossSpeciesExactMatch FBbt:00005173 thecogen cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000382 scolopale cell semapv:crossSpeciesExactMatch FBbt:00005219 scolopale cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000383 nephrogenic mesenchyme stem cell semapv:crossSpeciesExactMatch ZFA:0009187 nephrogenic mesenchyme stem cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000384 ligament cell semapv:crossSpeciesExactMatch ZFA:0009188 ligament cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000385 prohemocyte (sensu Nematoda and Protostomia) semapv:crossSpeciesExactMatch FBbt:00005062 prohemocyte semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000387 hemocyte (sensu Arthropoda) semapv:crossSpeciesExactMatch FBbt:00005063 hemocyte semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000388 tendon cell semapv:crossSpeciesExactMatch ZFA:0009189 tendon cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000393 electrically responsive cell semapv:crossSpeciesExactMatch ZFA:0009190 electrically responsive cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000394 plasmatocyte semapv:crossSpeciesExactMatch FBbt:00001685 embryonic/larval plasmatocyte semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000395 procrystal cell semapv:crossSpeciesExactMatch FBbt:00001689 procrystal cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000396 lamellocyte semapv:crossSpeciesExactMatch FBbt:00001687 lamellocyte semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000404 electrically signaling cell semapv:crossSpeciesExactMatch ZFA:0009193 electrically signaling cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000406 CNS short range interneuron semapv:crossSpeciesExactMatch ZFA:0009194 CNS short range interneuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000407 scolopidial ligament cell semapv:crossSpeciesExactMatch FBbt:00005221 scolopidial ligament cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000410 CNS long range interneuron semapv:crossSpeciesExactMatch ZFA:0009195 CNS long range interneuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000411 Caenorhabditis hypodermal cell semapv:crossSpeciesExactMatch WBbt:0007846 semapv:UnspecifiedMatching
+CL:0000411 Caenorhabditis hypodermal cell semapv:crossSpeciesExactMatch ZFA:0009196 hypodermal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000415 diploid cell semapv:crossSpeciesExactMatch FMA:72300 semapv:UnspecifiedMatching
+CL:0000418 arcade cell semapv:crossSpeciesExactMatch WBbt:0005793 semapv:UnspecifiedMatching
+CL:0000421 coelomocyte semapv:crossSpeciesExactMatch WBbt:0005751 semapv:UnspecifiedMatching
+CL:0000424 excretory cell semapv:crossSpeciesExactMatch WBbt:0005812 semapv:UnspecifiedMatching
+CL:0000428 yolk cell semapv:crossSpeciesExactMatch ZFA:0000084 yolk semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000429 imaginal disc cell semapv:crossSpeciesExactMatch FBbt:00007108 imaginal disc epithelial cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000430 xanthophore cell semapv:crossSpeciesExactMatch ZFA:0009198 xanthophore semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000431 iridophore semapv:crossSpeciesExactMatch ZFA:0009199 iridophore semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000432 reticular cell semapv:crossSpeciesExactMatch ZFA:0009200 reticular cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000432 reticular cell semapv:crossSpeciesExactMatch FMA:62877 semapv:UnspecifiedMatching
+CL:0000435 alkali secreting cell semapv:crossSpeciesExactMatch ZFA:0009201 alkali secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000437 gonadtroph semapv:crossSpeciesExactMatch ZFA:0009202 follicle stimulating hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000437 gonadtroph semapv:crossSpeciesExactMatch FMA:83100 semapv:UnspecifiedMatching
+CL:0000438 luteinizing hormone secreting cell semapv:crossSpeciesExactMatch ZFA:0009203 luteinizing hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000439 prolactin secreting cell semapv:crossSpeciesExactMatch ZFA:0009204 prolactin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000440 melanocyte stimulating hormone secreting cell semapv:crossSpeciesExactMatch ZFA:0009205 melanocyte stimulating hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000441 follicle stem cell (sensu Arthropoda) semapv:crossSpeciesExactMatch FBbt:00004903 follicle stem cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000442 follicular dendritic cell semapv:crossSpeciesExactMatch FMA:83037 semapv:UnspecifiedMatching
+CL:0000443 calcitonin secreting cell semapv:crossSpeciesExactMatch ZFA:0009206 calcitonin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000446 chief cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69078 semapv:UnspecifiedMatching
+CL:0000448 white adipocyte semapv:crossSpeciesExactMatch FMA:83434 semapv:UnspecifiedMatching
+CL:0000449 brown adipocyte semapv:crossSpeciesExactMatch FMA:83435 semapv:UnspecifiedMatching
+CL:0000451 dendritic cell semapv:crossSpeciesExactMatch ZFA:0009209 dendritic cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000451 dendritic cell semapv:crossSpeciesExactMatch FMA:83036 semapv:UnspecifiedMatching
+CL:0000452 thyroid hormone secreting cell semapv:crossSpeciesExactMatch ZFA:0009210 thyroid hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000453 Langerhans cell semapv:crossSpeciesExactMatch FMA:63072 semapv:UnspecifiedMatching
+CL:0000454 epinephrine secreting cell semapv:crossSpeciesExactMatch ZFA:0009211 epinephrin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000457 biogenic amine secreting cell semapv:crossSpeciesExactMatch ZFA:0009212 biogenic amine secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000458 serotonin secreting cell semapv:crossSpeciesExactMatch ZFA:0009213 serotonin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000459 noradrenergic cell semapv:crossSpeciesExactMatch ZFA:0009214 norepinephrine secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000460 glucocorticoid secreting cell semapv:crossSpeciesExactMatch ZFA:0009215 glucocorticoid secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000462 adepithelial cell semapv:crossSpeciesExactMatch FBbt:00003219 adepithelial cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000463 epidermal cell (sensu Arthropoda) semapv:crossSpeciesExactMatch FBbt:00007325 epidermal cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000464 epidermoblast semapv:crossSpeciesExactMatch FBbt:00004994 epidermoblast semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000465 cardioblast (sensu Arthropoda) semapv:crossSpeciesExactMatch FBbt:00001666 cardioblast semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000467 adrenocorticotropic hormone secreting cell semapv:crossSpeciesExactMatch ZFA:0009216 adrenocorticotropic hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000468 neuroglioblast (sensu Nematoda and Protostomia) semapv:crossSpeciesExactMatch FBbt:00005147 neuroglioblast semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000469 ganglion mother cell semapv:crossSpeciesExactMatch FBbt:00005149 ganglion mother cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000470 digestive enzyme secreting cell semapv:crossSpeciesExactMatch ZFA:0009217 digestive enzyme secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000474 pericardial nephrocyte semapv:crossSpeciesExactMatch FBbt:00005058 pericardial cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000476 thyrotroph semapv:crossSpeciesExactMatch ZFA:0009218 thyroid stimulating hormone secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000476 thyrotroph semapv:crossSpeciesExactMatch FMA:83099 semapv:UnspecifiedMatching
+CL:0000477 follicle cell of egg chamber semapv:crossSpeciesExactMatch FBbt:00004904 follicle cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000482 juvenile hormone secreting cell semapv:crossSpeciesExactMatch FBbt:00058020 juvenile hormone secreting cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000486 garland cell semapv:crossSpeciesExactMatch FBbt:00005059 garland cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000487 oenocyte semapv:crossSpeciesExactMatch FBbt:00004995 oenocyte semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000488 visible light photoreceptor cell semapv:crossSpeciesExactMatch ZFA:0009219 visible light photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000490 photopic photoreceptor cell semapv:crossSpeciesExactMatch ZFA:0009220 photopic photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000492 CD4-positive helper T cell semapv:crossSpeciesExactMatch FMA:70572 semapv:UnspecifiedMatching
+CL:0000494 UV sensitive photoreceptor cell semapv:crossSpeciesExactMatch ZFA:0009221 UV sensitive photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000495 blue sensitive photoreceptor cell semapv:crossSpeciesExactMatch ZFA:0009222 blue sensitive photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000496 green sensitive photoreceptor cell semapv:crossSpeciesExactMatch ZFA:0009223 green sensitive photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000497 red sensitive photoreceptor cell semapv:crossSpeciesExactMatch ZFA:0009224 red sensitive photoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000498 inhibitory interneuron semapv:crossSpeciesExactMatch ZFA:0009225 inhibitory interneuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000498 inhibitory interneuron semapv:crossSpeciesExactMatch FMA:84776 semapv:UnspecifiedMatching
+CL:0000499 stromal cell semapv:crossSpeciesExactMatch ZFA:0009226 stromal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000499 stromal cell semapv:crossSpeciesExactMatch FMA:83624 semapv:UnspecifiedMatching
+CL:0000501 granulosa cell semapv:crossSpeciesExactMatch ZFA:0009227 granulosa cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000501 granulosa cell semapv:crossSpeciesExactMatch FMA:18718 semapv:UnspecifiedMatching
+CL:0000502 type D enteroendocrine cell semapv:crossSpeciesExactMatch ZFA:0009228 D cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000502 type D enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62935 semapv:UnspecifiedMatching
+CL:0000503 theca cell semapv:crossSpeciesExactMatch ZFA:0009229 theca cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000505 substance P secreting cell semapv:crossSpeciesExactMatch ZFA:0009230 substance P secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000506 enkephalin secreting cell semapv:crossSpeciesExactMatch ZFA:0009231 enkephalin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000507 endorphin secreting cell semapv:crossSpeciesExactMatch ZFA:0009232 endorphin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000508 type G enteroendocrine cell semapv:crossSpeciesExactMatch FMA:67609 semapv:UnspecifiedMatching
+CL:0000510 paneth cell semapv:crossSpeciesExactMatch FMA:62897 semapv:UnspecifiedMatching
+CL:0000513 cardiac muscle myoblast semapv:crossSpeciesExactMatch ZFA:0009234 cardiac muscle myoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000513 cardiac muscle myoblast semapv:crossSpeciesExactMatch FMA:84797 semapv:UnspecifiedMatching
+CL:0000514 smooth muscle myoblast semapv:crossSpeciesExactMatch ZFA:0009235 smooth muscle myoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000514 smooth muscle myoblast semapv:crossSpeciesExactMatch FMA:84798 semapv:UnspecifiedMatching
+CL:0000515 skeletal muscle myoblast semapv:crossSpeciesExactMatch ZFA:0009236 skeletal muscle myoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000515 skeletal muscle myoblast semapv:crossSpeciesExactMatch FMA:84799 semapv:UnspecifiedMatching
+CL:0000516 perineuronal satellite cell semapv:crossSpeciesExactMatch ZFA:0009237 perineuronal satellite cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000516 perineuronal satellite cell semapv:crossSpeciesExactMatch FMA:54550 semapv:UnspecifiedMatching
+CL:0000523 mononuclear cytotrophoblast cell semapv:crossSpeciesExactMatch FMA:83042 semapv:UnspecifiedMatching
+CL:0000525 syncytiotrophoblast cell semapv:crossSpeciesExactMatch FMA:83043 semapv:UnspecifiedMatching
+CL:0000526 afferent neuron semapv:crossSpeciesExactMatch ZFA:0009238 afferent neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000526 afferent neuron semapv:crossSpeciesExactMatch FMA:87653 semapv:UnspecifiedMatching
+CL:0000527 efferent neuron semapv:crossSpeciesExactMatch ZFA:0009239 efferent neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000528 nitrergic neuron semapv:crossSpeciesExactMatch ZFA:0009240 nitrergic neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000528 nitrergic neuron semapv:crossSpeciesExactMatch FMA:84792 semapv:UnspecifiedMatching
+CL:0000529 pigmented epithelial cell semapv:crossSpeciesExactMatch ZFA:0009241 pigmented epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000530 primary neuron (sensu Teleostei) semapv:crossSpeciesExactMatch ZFA:0009242 primary neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000532 CAP motoneuron semapv:crossSpeciesExactMatch ZFA:0009243 CaP motoneuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000533 primary motor neuron (sensu Teleostei) semapv:crossSpeciesExactMatch ZFA:0009244 primary motor neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000534 primary interneuron (sensu Teleostei) semapv:crossSpeciesExactMatch ZFA:0009245 primary interneuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000535 secondary neuron (sensu Teleostei) semapv:crossSpeciesExactMatch ZFA:0009246 secondary neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000536 secondary motor neuron (sensu Teleostei) semapv:crossSpeciesExactMatch ZFA:0009247 secondary motor neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000540 neuron skos:broadMatch VHOG:0001483 semapv:UnspecifiedMatching
+CL:0000540 neuron semapv:crossSpeciesExactMatch FBbt:00005106 neuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000540 neuron semapv:crossSpeciesExactMatch WBbt:0003679 semapv:UnspecifiedMatching
+CL:0000540 neuron semapv:crossSpeciesExactMatch ZFA:0009248 neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000540 neuron semapv:crossSpeciesExactMatch FMA:54527 semapv:UnspecifiedMatching
+CL:0000541 melanoblast semapv:crossSpeciesExactMatch ZFA:0009249 melanoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000541 melanoblast semapv:crossSpeciesExactMatch FMA:83377 semapv:UnspecifiedMatching
+CL:0000542 lymphocyte skos:broadMatch VHOG:0001535 semapv:UnspecifiedMatching
+CL:0000542 lymphocyte semapv:crossSpeciesExactMatch ZFA:0009250 lymphocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000542 lymphocyte semapv:crossSpeciesExactMatch FMA:62863 semapv:UnspecifiedMatching
+CL:0000545 T-helper 1 cell semapv:crossSpeciesExactMatch FMA:84382 semapv:UnspecifiedMatching
+CL:0000546 T-helper 2 cell semapv:crossSpeciesExactMatch FMA:84385 semapv:UnspecifiedMatching
+CL:0000547 proerythroblast semapv:crossSpeciesExactMatch FMA:83518 semapv:UnspecifiedMatching
+CL:0000549 basophilic erythroblast semapv:crossSpeciesExactMatch ZFA:0005236 basophilic erythroblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000549 basophilic erythroblast semapv:crossSpeciesExactMatch FMA:83505 semapv:UnspecifiedMatching
+CL:0000550 polychromatophilic erythroblast semapv:crossSpeciesExactMatch ZFA:0005241 polychromatophilic erythroblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000550 polychromatophilic erythroblast semapv:crossSpeciesExactMatch FMA:83506 semapv:UnspecifiedMatching
+CL:0000552 orthochromatic erythroblast semapv:crossSpeciesExactMatch FMA:84646 semapv:UnspecifiedMatching
+CL:0000553 megakaryocyte progenitor cell semapv:crossSpeciesExactMatch FMA:84235 semapv:UnspecifiedMatching
+CL:0000556 megakaryocyte semapv:crossSpeciesExactMatch FMA:83555 semapv:UnspecifiedMatching
+CL:0000557 granulocyte monocyte progenitor cell semapv:crossSpeciesExactMatch ZFA:0009251 granulocyte monocyte progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000558 reticulocyte semapv:crossSpeciesExactMatch ZFA:0009252 reticulocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000559 promonocyte semapv:crossSpeciesExactMatch ZFA:0009253 promonocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000559 promonocyte semapv:crossSpeciesExactMatch FMA:83551 semapv:UnspecifiedMatching
+CL:0000560 band form neutrophil semapv:crossSpeciesExactMatch ZFA:0009254 band form neutrophil semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000561 amacrine cell semapv:crossSpeciesExactMatch ZFA:0009255 amacrine cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000561 amacrine cell semapv:crossSpeciesExactMatch FMA:67766 semapv:UnspecifiedMatching
+CL:0000562 nucleate erythrocyte semapv:crossSpeciesExactMatch ZFA:0009256 nucleate erythrocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000564 neutrophilic promyelocyte semapv:crossSpeciesExactMatch ZFA:0009257 neutrophilic promyelocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000564 neutrophilic promyelocyte semapv:crossSpeciesExactMatch FMA:84196 semapv:UnspecifiedMatching
+CL:0000566 angioblastic mesenchymal cell semapv:crossSpeciesExactMatch ZFA:0009258 angioblastic mesenchymal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000568 amine precursor uptake and decarboxylation cell semapv:crossSpeciesExactMatch FMA:83114 semapv:UnspecifiedMatching
+CL:0000569 cardiac mesenchymal cell semapv:crossSpeciesExactMatch ZFA:0009259 cardiac mesenchymal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000570 parafollicular cell skos:narrowMatch SCTID:176770005 semapv:UnspecifiedMatching
+CL:0000570 parafollicular cell semapv:crossSpeciesExactMatch ZFA:0009260 parafollicular cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000570 parafollicular cell semapv:crossSpeciesExactMatch FMA:68653 semapv:UnspecifiedMatching
+CL:0000571 leucophore semapv:crossSpeciesExactMatch ZFA:0009261 leucophore semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000573 retinal cone cell semapv:crossSpeciesExactMatch ZFA:0009262 retinal cone cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000573 retinal cone cell semapv:crossSpeciesExactMatch FMA:67748 semapv:UnspecifiedMatching
+CL:0000574 erythrophore semapv:crossSpeciesExactMatch ZFA:0009263 erythrophore semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000575 corneal epithelial cell semapv:crossSpeciesExactMatch ZFA:0009264 corneal epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000575 corneal epithelial cell semapv:crossSpeciesExactMatch FMA:70551 semapv:UnspecifiedMatching
+CL:0000576 monocyte semapv:crossSpeciesExactMatch ZFA:0009265 monocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000576 monocyte semapv:crossSpeciesExactMatch FMA:62864 semapv:UnspecifiedMatching
+CL:0000577 type EC enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62934 semapv:UnspecifiedMatching
+CL:0000577 type EC enteroendocrine cell semapv:crossSpeciesExactMatch FMA:83132 semapv:UnspecifiedMatching
+CL:0000579 border follicle cell semapv:crossSpeciesExactMatch FBbt:00004905 border follicle cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000580 neutrophilic myelocyte semapv:crossSpeciesExactMatch ZFA:0009266 neutrophilic myelocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000580 neutrophilic myelocyte semapv:crossSpeciesExactMatch FMA:83540 semapv:UnspecifiedMatching
+CL:0000581 peritoneal macrophage semapv:crossSpeciesExactMatch ZFA:0009267 peritoneal macrophage semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000581 peritoneal macrophage semapv:crossSpeciesExactMatch FMA:83025 semapv:UnspecifiedMatching
+CL:0000582 neutrophilic metamyelocyte semapv:crossSpeciesExactMatch ZFA:0009268 neutrophilic metamyelocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000582 neutrophilic metamyelocyte semapv:crossSpeciesExactMatch FMA:84197 semapv:UnspecifiedMatching
+CL:0000583 alveolar macrophage semapv:crossSpeciesExactMatch FMA:83023 semapv:UnspecifiedMatching
+CL:0000584 enterocyte semapv:crossSpeciesExactMatch ZFA:0009269 enterocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000584 enterocyte semapv:crossSpeciesExactMatch FMA:62122 semapv:UnspecifiedMatching
+CL:0000586 germ cell skos:broadMatch VHOG:0001534 semapv:UnspecifiedMatching
+CL:0000586 germ cell skos:narrowMatch NCIT:C12597 semapv:UnspecifiedMatching
+CL:0000586 germ cell semapv:crossSpeciesExactMatch WBbt:0006796 semapv:UnspecifiedMatching
+CL:0000588 odontoclast semapv:crossSpeciesExactMatch ZFA:0009270 odontoclast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000588 odontoclast semapv:crossSpeciesExactMatch FMA:83027 semapv:UnspecifiedMatching
+CL:0000589 cochlear inner hair cell semapv:crossSpeciesExactMatch FMA:62365 semapv:UnspecifiedMatching
+CL:0000590 small luteal cell semapv:crossSpeciesExactMatch FMA:18690 semapv:UnspecifiedMatching
+CL:0000592 large luteal cell semapv:crossSpeciesExactMatch FMA:18689 semapv:UnspecifiedMatching
+CL:0000593 androgen secreting cell semapv:crossSpeciesExactMatch ZFA:0009271 androgen secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000594 skeletal muscle satellite cell semapv:crossSpeciesExactMatch ZFA:0009272 skeletal muscle satellite cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000598 pyramidal neuron semapv:crossSpeciesExactMatch ZFA:0009273 pyramidal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000598 pyramidal neuron semapv:crossSpeciesExactMatch FMA:67310 semapv:UnspecifiedMatching
+CL:0000598 pyramidal neuron semapv:crossSpeciesExactMatch FMA:86775 semapv:UnspecifiedMatching
+CL:0000601 cochlear outer hair cell semapv:crossSpeciesExactMatch FMA:62366 semapv:UnspecifiedMatching
+CL:0000602 pressoreceptor cell semapv:crossSpeciesExactMatch ZFA:0009274 pressoreceptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000604 retinal rod cell semapv:crossSpeciesExactMatch ZFA:0009275 retinal rod cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000604 retinal rod cell semapv:crossSpeciesExactMatch FMA:67747 semapv:UnspecifiedMatching
+CL:0000609 vestibular hair cell semapv:crossSpeciesExactMatch FMA:62351 semapv:UnspecifiedMatching
+CL:0000612 eosinophilic myelocyte semapv:crossSpeciesExactMatch FMA:83542 semapv:UnspecifiedMatching
+CL:0000614 basophilic myelocyte semapv:crossSpeciesExactMatch FMA:83543 semapv:UnspecifiedMatching
+CL:0000617 GABAergic neuron semapv:crossSpeciesExactMatch FBbt:00007228 GABAergic neuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000617 GABAergic neuron semapv:crossSpeciesExactMatch WBbt:0005190 semapv:UnspecifiedMatching
+CL:0000617 GABAergic neuron semapv:crossSpeciesExactMatch ZFA:0009276 GABAergic neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000617 GABAergic neuron semapv:crossSpeciesExactMatch FMA:84788 semapv:UnspecifiedMatching
+CL:0000622 acinar cell semapv:crossSpeciesExactMatch ZFA:0009277 acinar cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000622 acinar cell semapv:crossSpeciesExactMatch FMA:83625 semapv:UnspecifiedMatching
+CL:0000623 natural killer cell skos:broadMatch VHOG:0001697 semapv:UnspecifiedMatching
+CL:0000623 natural killer cell semapv:crossSpeciesExactMatch ZFA:0009278 natural killer cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000623 natural killer cell semapv:crossSpeciesExactMatch FMA:63147 semapv:UnspecifiedMatching
+CL:0000623 natural killer cell semapv:crossSpeciesExactMatch FMA:83601 semapv:UnspecifiedMatching
+CL:0000626 olfactory granule cell semapv:crossSpeciesExactMatch ZFA:0001694 olfactory granule cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000630 supporting cell semapv:crossSpeciesExactMatch ZFA:0009387 supportive cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000632 hepatic stellate cell semapv:crossSpeciesExactMatch ZFA:0009279 ito cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000632 hepatic stellate cell semapv:crossSpeciesExactMatch FMA:67763 semapv:UnspecifiedMatching
+CL:0000633 Hensen cell semapv:crossSpeciesExactMatch FMA:79799 semapv:UnspecifiedMatching
+CL:0000634 Claudius cell semapv:crossSpeciesExactMatch FMA:79802 semapv:UnspecifiedMatching
+CL:0000635 Deiter's cell semapv:crossSpeciesExactMatch FMA:75725 semapv:UnspecifiedMatching
+CL:0000636 Mueller cell semapv:crossSpeciesExactMatch ZFA:0009280 Muller cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000637 chromophil cell of anterior pituitary gland semapv:crossSpeciesExactMatch FMA:83089 semapv:UnspecifiedMatching
+CL:0000638 acidophil cell of pars distalis of adenohypophysis semapv:crossSpeciesExactMatch FMA:83093 semapv:UnspecifiedMatching
+CL:0000639 basophil cell of pars distalis of adenohypophysis semapv:crossSpeciesExactMatch FMA:83094 semapv:UnspecifiedMatching
+CL:0000641 chromophobe cell semapv:crossSpeciesExactMatch FMA:83626 semapv:UnspecifiedMatching
+CL:0000642 folliculostellate cell semapv:crossSpeciesExactMatch ZFA:0009281 folliculostellate cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000644 Bergmann glial cell semapv:crossSpeciesExactMatch ZFA:0009282 Bergmann glial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000644 Bergmann glial cell semapv:crossSpeciesExactMatch FMA:54559 semapv:UnspecifiedMatching
+CL:0000645 pituicyte semapv:crossSpeciesExactMatch FMA:83503 semapv:UnspecifiedMatching
+CL:0000646 basal cell semapv:crossSpeciesExactMatch FMA:62516 semapv:UnspecifiedMatching
+CL:0000647 multinucleated giant cell semapv:crossSpeciesExactMatch FMA:83035 semapv:UnspecifiedMatching
+CL:0000648 kidney granular cell semapv:crossSpeciesExactMatch ZFA:0005238 juxtaglomerular cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000648 kidney granular cell semapv:crossSpeciesExactMatch FMA:84138 semapv:UnspecifiedMatching
+CL:0000649 prickle cell semapv:crossSpeciesExactMatch FMA:69059 semapv:UnspecifiedMatching
+CL:0000650 mesangial cell semapv:crossSpeciesExactMatch ZFA:0009283 mesangial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000650 mesangial cell semapv:crossSpeciesExactMatch FMA:70972 semapv:UnspecifiedMatching
+CL:0000652 pinealocyte semapv:crossSpeciesExactMatch ZFA:0009284 pinealocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000652 pinealocyte semapv:crossSpeciesExactMatch FMA:83417 semapv:UnspecifiedMatching
+CL:0000653 podocyte semapv:crossSpeciesExactMatch ZFA:0009285 podocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000653 podocyte semapv:crossSpeciesExactMatch FMA:70967 semapv:UnspecifiedMatching
+CL:0000654 primary oocyte semapv:crossSpeciesExactMatch FMA:18645 semapv:UnspecifiedMatching
+CL:0000655 secondary oocyte semapv:crossSpeciesExactMatch FMA:18646 semapv:UnspecifiedMatching
+CL:0000656 primary spermatocyte semapv:crossSpeciesExactMatch FMA:72292 semapv:UnspecifiedMatching
+CL:0000657 secondary spermatocyte semapv:crossSpeciesExactMatch FBbt:00004941 secondary spermatocyte semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000657 secondary spermatocyte semapv:crossSpeciesExactMatch FMA:72293 semapv:UnspecifiedMatching
+CL:0000666 fenestrated endothelial cell semapv:crossSpeciesExactMatch ZFA:0009286 fenestrated cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000667 collagen secreting cell semapv:crossSpeciesExactMatch ZFA:0009287 collagen secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000669 pericyte semapv:crossSpeciesExactMatch ZFA:0009112 pericyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000669 pericyte semapv:crossSpeciesExactMatch FMA:63174 semapv:UnspecifiedMatching
+CL:0000670 primordial germ cell semapv:crossSpeciesExactMatch ZFA:0009288 primordial germ cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000670 primordial germ cell semapv:crossSpeciesExactMatch FMA:70567 semapv:UnspecifiedMatching
+CL:0000671 centripetally migrating follicle cell semapv:crossSpeciesExactMatch FBbt:00004906 centripetal follicle cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000673 Kenyon cell semapv:crossSpeciesExactMatch FBbt:00003686 Kenyon cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000674 interfollicle cell semapv:crossSpeciesExactMatch FBbt:00004910 stalk follicle cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000677 gut absorptive cell semapv:crossSpeciesExactMatch ZFA:0009289 gut absorptive cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000679 glutamatergic neuron semapv:crossSpeciesExactMatch FBbt:00100291 glutamatergic neuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000679 glutamatergic neuron semapv:crossSpeciesExactMatch WBbt:0006829 semapv:UnspecifiedMatching
+CL:0000679 glutamatergic neuron semapv:crossSpeciesExactMatch ZFA:0009290 glutamatergic neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000680 muscle precursor cell semapv:crossSpeciesExactMatch ZFA:0009291 muscle precursor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000681 radial glial cell semapv:crossSpeciesExactMatch ZFA:0009292 radial glial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000682 M cell of gut semapv:crossSpeciesExactMatch ZFA:0009293 M cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000682 M cell of gut semapv:crossSpeciesExactMatch FMA:62929 semapv:UnspecifiedMatching
+CL:0000683 ependymoglial cell semapv:crossSpeciesExactMatch ZFA:0009294 ependymoglial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000686 cerebrospinal fluid secreting cell semapv:crossSpeciesExactMatch ZFA:0009295 cerebrospinal fluid secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000687 R1 photoreceptor cell semapv:crossSpeciesExactMatch FBbt:00004213 photoreceptor cell R1 semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000688 perijunctional fibroblast semapv:crossSpeciesExactMatch ZFA:0009296 perijunctional fibroblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000690 R2 photoreceptor cell semapv:crossSpeciesExactMatch FBbt:00004215 photoreceptor cell R2 semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000691 stellate interneuron semapv:crossSpeciesExactMatch ZFA:0009297 stellate interneuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000692 terminal Schwann cell semapv:crossSpeciesExactMatch ZFA:0009298 terminal Schwann cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000693 neurogliaform cell semapv:crossSpeciesExactMatch ZFA:0009299 neuroglioform cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000694 R3 photoreceptor cell semapv:crossSpeciesExactMatch FBbt:00004217 photoreceptor cell R3 semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000695 Cajal-Retzius cell semapv:crossSpeciesExactMatch ZFA:0009300 Cajal-Retzius cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000696 PP cell semapv:crossSpeciesExactMatch FMA:62938 semapv:UnspecifiedMatching
+CL:0000696 PP cell semapv:crossSpeciesExactMatch FMA:83409 semapv:UnspecifiedMatching
+CL:0000697 R4 photoreceptor cell semapv:crossSpeciesExactMatch FBbt:00004219 photoreceptor cell R4 semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000700 dopaminergic neuron semapv:crossSpeciesExactMatch FBbt:00005131 dopaminergic neuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000700 dopaminergic neuron semapv:crossSpeciesExactMatch WBbt:0006746 semapv:UnspecifiedMatching
+CL:0000700 dopaminergic neuron semapv:crossSpeciesExactMatch ZFA:0009301 dopaminergic neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000700 dopaminergic neuron semapv:crossSpeciesExactMatch FMA:84787 semapv:UnspecifiedMatching
+CL:0000702 R5 photoreceptor cell semapv:crossSpeciesExactMatch FBbt:00004221 photoreceptor cell R5 semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000703 sustentacular cell semapv:crossSpeciesExactMatch ZFA:0009302 sustentacular cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000704 endothelial tip cell semapv:crossSpeciesExactMatch ZFA:0009303 endothelial tip cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000705 R6 photoreceptor cell semapv:crossSpeciesExactMatch FBbt:00004223 photoreceptor cell R6 semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000706 choroid plexus epithelial cell semapv:crossSpeciesExactMatch ZFA:0009304 choroid plexus epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000706 choroid plexus epithelial cell semapv:crossSpeciesExactMatch FMA:70549 semapv:UnspecifiedMatching
+CL:0000707 R7 photoreceptor cell semapv:crossSpeciesExactMatch FBbt:00004225 photoreceptor cell R7 semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000708 leptomeningeal cell semapv:crossSpeciesExactMatch ZFA:0009305 leptomeningeal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000709 R8 photoreceptor cell semapv:crossSpeciesExactMatch FBbt:00004227 photoreceptor cell R8 semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000710 neurecto-epithelial cell semapv:crossSpeciesExactMatch FMA:70557 semapv:UnspecifiedMatching
+CL:0000715 embryonic crystal cell semapv:crossSpeciesExactMatch FBbt:00001690 embryonic/larval crystal cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000718 compound eye cone cell semapv:crossSpeciesExactMatch FBbt:00004193 cone cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000723 somatic stem cell semapv:crossSpeciesExactMatch ZFA:0009307 somatic stem cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000731 urothelial cell semapv:crossSpeciesExactMatch ZFA:0009308 urothelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000731 urothelial cell semapv:crossSpeciesExactMatch FMA:84127 semapv:UnspecifiedMatching
+CL:0000735 lymph gland hemocyte semapv:crossSpeciesExactMatch FBbt:00005917 lymph gland derived hemocyte semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000737 striated muscle cell semapv:crossSpeciesExactMatch ZFA:0005784 striated muscle cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000737 striated muscle cell semapv:crossSpeciesExactMatch FMA:86936 semapv:UnspecifiedMatching
+CL:0000738 leukocyte skos:narrowMatch NCIT:C12529 semapv:UnspecifiedMatching
+CL:0000738 leukocyte semapv:crossSpeciesExactMatch ZFA:0009309 leukocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000738 leukocyte semapv:crossSpeciesExactMatch FMA:62852 semapv:UnspecifiedMatching
+CL:0000740 retinal ganglion cell semapv:crossSpeciesExactMatch ZFA:0009310 retinal ganglion cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000740 retinal ganglion cell semapv:crossSpeciesExactMatch FMA:67765 semapv:UnspecifiedMatching
+CL:0000741 spinal accessory motor neuron semapv:crossSpeciesExactMatch ZFA:0009311 spinal accessory motor neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000742 periarticular chondrocyte semapv:crossSpeciesExactMatch ZFA:0009312 periarticular chondrocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000743 hypertrophic chondrocyte semapv:crossSpeciesExactMatch ZFA:0009313 hypertrophic chondrocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000744 columnar chondrocyte semapv:crossSpeciesExactMatch ZFA:0009314 columnar chondrocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000745 retina horizontal cell semapv:crossSpeciesExactMatch ZFA:0009315 horizontal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000746 cardiac muscle cell semapv:crossSpeciesExactMatch ZFA:0009316 cardiac muscle cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000746 cardiac muscle cell semapv:crossSpeciesExactMatch FMA:14067 semapv:UnspecifiedMatching
+CL:0000747 cyanophore semapv:crossSpeciesExactMatch ZFA:0009317 cyanophore semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000748 retinal bipolar neuron semapv:crossSpeciesExactMatch ZFA:0009318 retinal bipolar neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000749 ON-bipolar cell semapv:crossSpeciesExactMatch ZFA:0009319 ON-bipolar cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000750 OFF-bipolar cell semapv:crossSpeciesExactMatch ZFA:0009320 OFF-bipolar cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000751 rod bipolar cell semapv:crossSpeciesExactMatch ZFA:0009321 rod bipolar cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000751 rod bipolar cell semapv:crossSpeciesExactMatch FMA:67750 semapv:UnspecifiedMatching
+CL:0000752 cone retinal bipolar cell semapv:crossSpeciesExactMatch ZFA:0009322 cone retinal bipolar cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000762 nucleated thrombocyte semapv:crossSpeciesExactMatch ZFA:0009323 thrombocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000763 myeloid cell semapv:crossSpeciesExactMatch ZFA:0009324 myeloid cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000764 erythroid lineage cell semapv:crossSpeciesExactMatch ZFA:0009325 erythroid lineage cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000764 erythroid lineage cell semapv:crossSpeciesExactMatch FMA:62845 semapv:UnspecifiedMatching
+CL:0000764 erythroid lineage cell semapv:crossSpeciesExactMatch FMA:83516 semapv:UnspecifiedMatching
+CL:0000765 erythroblast semapv:crossSpeciesExactMatch ZFA:0005237 erythroblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000765 erythroblast semapv:crossSpeciesExactMatch FMA:83504 semapv:UnspecifiedMatching
+CL:0000766 myeloid leukocyte semapv:crossSpeciesExactMatch ZFA:0009326 myeloid leukocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000767 basophil semapv:crossSpeciesExactMatch FMA:62862 semapv:UnspecifiedMatching
+CL:0000769 basophilic metamyelocyte semapv:crossSpeciesExactMatch FMA:84198 semapv:UnspecifiedMatching
+CL:0000771 eosinophil semapv:crossSpeciesExactMatch FMA:62861 semapv:UnspecifiedMatching
+CL:0000775 neutrophil semapv:crossSpeciesExactMatch ZFA:0009327 neutrophil semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000775 neutrophil semapv:crossSpeciesExactMatch FMA:62860 semapv:UnspecifiedMatching
+CL:0000776 immature neutrophil semapv:crossSpeciesExactMatch ZFA:0009328 immature neutrophil semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000778 mononuclear osteoclast semapv:crossSpeciesExactMatch ZFA:0009329 mononuclear osteoclast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000781 mononuclear odontoclast semapv:crossSpeciesExactMatch ZFA:0009330 mononuclear odontoclast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000785 mature B cell semapv:crossSpeciesExactMatch ZFA:0009331 mature B cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000786 plasma cell semapv:crossSpeciesExactMatch ZFA:0009332 plasma cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000786 plasma cell semapv:crossSpeciesExactMatch FMA:70574 semapv:UnspecifiedMatching
+CL:0000787 memory B cell semapv:crossSpeciesExactMatch ZFA:0009333 memory B cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000788 naive B cell semapv:crossSpeciesExactMatch ZFA:0009334 naive B cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000789 alpha-beta T cell semapv:crossSpeciesExactMatch ZFA:0009335 alpha-beta T cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000798 gamma-delta T cell semapv:crossSpeciesExactMatch ZFA:0009336 gamma-delta T cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000799 immature gamma-delta T cell semapv:crossSpeciesExactMatch ZFA:0009337 immature gamma-delta T cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000800 mature gamma-delta T cell semapv:crossSpeciesExactMatch ZFA:0009338 mature gamma-delta T cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000801 gamma-delta intraepithelial T cell semapv:crossSpeciesExactMatch ZFA:0009339 gamma-delta intraepithelial T cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000813 memory T cell semapv:crossSpeciesExactMatch ZFA:0009342 memory T cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000815 regulatory T cell semapv:crossSpeciesExactMatch FMA:84070 semapv:UnspecifiedMatching
+CL:0000816 immature B cell semapv:crossSpeciesExactMatch ZFA:0009343 immature B cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000817 precursor B cell semapv:crossSpeciesExactMatch ZFA:0009344 precursor B cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000818 transitional stage B cell semapv:crossSpeciesExactMatch ZFA:0009345 transitional stage B cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000823 immature natural killer cell semapv:crossSpeciesExactMatch ZFA:0009346 immature natural killer cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000824 mature natural killer cell semapv:crossSpeciesExactMatch ZFA:0009347 mature natural killer cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000825 pro-NK cell semapv:crossSpeciesExactMatch ZFA:0009348 pro-NK cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000826 pro-B cell semapv:crossSpeciesExactMatch ZFA:0009349 pro-B cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000827 pro-T cell semapv:crossSpeciesExactMatch ZFA:0009350 pro-T cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000828 thromboblast semapv:crossSpeciesExactMatch ZFA:0009351 thromboblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000830 basophilic promyelocyte semapv:crossSpeciesExactMatch FMA:84208 semapv:UnspecifiedMatching
+CL:0000833 eosinophilic promyelocyte semapv:crossSpeciesExactMatch FMA:84199 semapv:UnspecifiedMatching
+CL:0000834 neutrophil progenitor cell semapv:crossSpeciesExactMatch ZFA:0009352 neutrophil progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000835 myeloblast semapv:crossSpeciesExactMatch ZFA:0009353 myeloblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000835 myeloblast semapv:crossSpeciesExactMatch FMA:83524 semapv:UnspecifiedMatching
+CL:0000836 promyelocyte semapv:crossSpeciesExactMatch FMA:83530 semapv:UnspecifiedMatching
+CL:0000837 hematopoietic multipotent progenitor cell semapv:crossSpeciesExactMatch ZFA:0009354 hematopoietic multipotent progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000838 lymphoid lineage restricted progenitor cell semapv:crossSpeciesExactMatch ZFA:0009355 lymphoid progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000838 lymphoid lineage restricted progenitor cell semapv:crossSpeciesExactMatch FMA:70338 semapv:UnspecifiedMatching
+CL:0000839 myeloid lineage restricted progenitor cell semapv:crossSpeciesExactMatch ZFA:0009356 myeloid lineage restricted progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000839 myeloid lineage restricted progenitor cell semapv:crossSpeciesExactMatch FMA:70339 semapv:UnspecifiedMatching
+CL:0000841 mature conventional dendritic cell semapv:crossSpeciesExactMatch FMA:83038 semapv:UnspecifiedMatching
+CL:0000842 mononuclear cell semapv:crossSpeciesExactMatch ZFA:0009357 mononuclear cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000842 mononuclear cell semapv:crossSpeciesExactMatch FMA:86713 semapv:UnspecifiedMatching
+CL:0000847 ciliated olfactory receptor neuron semapv:crossSpeciesExactMatch ZFA:0009358 ciliated olfactory receptor neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000848 microvillous olfactory receptor neuron semapv:crossSpeciesExactMatch ZFA:0009359 microvillous olfactory receptor neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000849 crypt olfactory receptor neuron semapv:crossSpeciesExactMatch ZFA:0009360 crypt olfactory receptor neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000850 serotonergic neuron semapv:crossSpeciesExactMatch FBbt:00005133 serotonergic neuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0000850 serotonergic neuron semapv:crossSpeciesExactMatch WBbt:0006837 semapv:UnspecifiedMatching
+CL:0000850 serotonergic neuron semapv:crossSpeciesExactMatch ZFA:0009361 serotonergic neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000851 neuromast mantle cell semapv:crossSpeciesExactMatch ZFA:0009362 neuromast mantle cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000852 neuromast supporting cell semapv:crossSpeciesExactMatch ZFA:0009363 neuromast support cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000853 olfactory epithelial supporting cell semapv:crossSpeciesExactMatch ZFA:0009364 olfactory epithelial support cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000853 olfactory epithelial supporting cell semapv:crossSpeciesExactMatch FMA:62302 semapv:UnspecifiedMatching
+CL:0000854 interneuromast cell semapv:crossSpeciesExactMatch ZFA:0009365 interneuromast cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000855 sensory hair cell semapv:crossSpeciesExactMatch ZFA:0009366 hair cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000856 neuromast hair cell semapv:crossSpeciesExactMatch ZFA:0009367 neuromast hair cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000857 slow muscle myoblast semapv:crossSpeciesExactMatch ZFA:0009368 slow muscle myoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000858 fast muscle myoblast semapv:crossSpeciesExactMatch ZFA:0009369 fast muscle myoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000861 elicited macrophage semapv:crossSpeciesExactMatch FMA:84643 semapv:UnspecifiedMatching
+CL:0000861 elicited macrophage semapv:crossSpeciesExactMatch FMA:84645 semapv:UnspecifiedMatching
+CL:0000864 tissue-resident macrophage semapv:crossSpeciesExactMatch FMA:84642 semapv:UnspecifiedMatching
+CL:0000864 tissue-resident macrophage semapv:crossSpeciesExactMatch FMA:84644 semapv:UnspecifiedMatching
+CL:0000871 splenic macrophage semapv:crossSpeciesExactMatch FMA:83026 semapv:UnspecifiedMatching
+CL:0000891 foam cell semapv:crossSpeciesExactMatch FMA:83586 semapv:UnspecifiedMatching
+CL:0000893 thymocyte semapv:crossSpeciesExactMatch XAO:0003159 semapv:UnspecifiedMatching
+CL:0000893 thymocyte semapv:crossSpeciesExactMatch FMA:72202 semapv:UnspecifiedMatching
+CL:0000910 cytotoxic T cell semapv:crossSpeciesExactMatch FMA:70573 semapv:UnspecifiedMatching
+CL:0000917 Tc1 cell semapv:crossSpeciesExactMatch FMA:84793 semapv:UnspecifiedMatching
+CL:0000918 Tc2 cell semapv:crossSpeciesExactMatch FMA:84794 semapv:UnspecifiedMatching
+CL:0000980 plasmablast semapv:crossSpeciesExactMatch FMA:84371 semapv:UnspecifiedMatching
+CL:0000988 hematopoietic cell semapv:crossSpeciesExactMatch ZFA:0005830 hematopoietic cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0000988 hematopoietic cell semapv:crossSpeciesExactMatch FMA:70366 semapv:UnspecifiedMatching
+CL:0000988 hematopoietic cell semapv:crossSpeciesExactMatch FMA:83598 semapv:UnspecifiedMatching
+CL:0000990 conventional dendritic cell semapv:crossSpeciesExactMatch FMA:84191 semapv:UnspecifiedMatching
+CL:0001031 cerebellar granule cell semapv:crossSpeciesExactMatch ZFA:0001691 cerebellar granule cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0001039 terminally differentiated osteoblast skos:exactMatch VSAO:0000116 semapv:UnspecifiedMatching
+CL:0001040 non-terminally differentiated osteoblast skos:exactMatch VSAO:0000117 semapv:UnspecifiedMatching
+CL:0001658 visual pigment cell (sensu Nematoda and Protostomia) semapv:crossSpeciesExactMatch FBbt:00004230 pigment cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0002003 CD34-positive, GlyA-negative erythroid progenitor cell semapv:crossSpeciesExactMatch FMA:83517 semapv:UnspecifiedMatching
+CL:0002062 pulmonary alveolar type 1 cell semapv:crossSpeciesExactMatch FMA:62500 semapv:UnspecifiedMatching
+CL:0002063 pulmonary alveolar type 2 cell semapv:crossSpeciesExactMatch FMA:62501 semapv:UnspecifiedMatching
+CL:0002064 pancreatic acinar cell semapv:crossSpeciesExactMatch ZFA:0005739 pancreatic acinar cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002064 pancreatic acinar cell semapv:crossSpeciesExactMatch FMA:63032 semapv:UnspecifiedMatching
+CL:0002066 Feyrter cell semapv:crossSpeciesExactMatch FMA:14118 semapv:UnspecifiedMatching
+CL:0002067 type A enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62939 semapv:UnspecifiedMatching
+CL:0002068 Purkinje myocyte semapv:crossSpeciesExactMatch FMA:14146 semapv:UnspecifiedMatching
+CL:0002069 type II vestibular sensory cell semapv:crossSpeciesExactMatch FMA:67909 semapv:UnspecifiedMatching
+CL:0002070 type I vestibular sensory cell semapv:crossSpeciesExactMatch FMA:62352 semapv:UnspecifiedMatching
+CL:0002071 enterocyte of epithelium of large intestine semapv:crossSpeciesExactMatch FMA:63638 semapv:UnspecifiedMatching
+CL:0002071 enterocyte of epithelium of large intestine semapv:crossSpeciesExactMatch FMA:66771 semapv:UnspecifiedMatching
+CL:0002072 nodal myocyte semapv:crossSpeciesExactMatch FMA:67101 semapv:UnspecifiedMatching
+CL:0002073 transitional myocyte semapv:crossSpeciesExactMatch FMA:67142 semapv:UnspecifiedMatching
+CL:0002074 myocardial endocrine cell semapv:crossSpeciesExactMatch FMA:67111 semapv:UnspecifiedMatching
+CL:0002076 endo-epithelial cell semapv:crossSpeciesExactMatch ZFA:0009383 endo-epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002076 endo-epithelial cell semapv:crossSpeciesExactMatch FMA:69075 semapv:UnspecifiedMatching
+CL:0002077 ecto-epithelial cell semapv:crossSpeciesExactMatch ZFA:0009385 ecto-epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002077 ecto-epithelial cell semapv:crossSpeciesExactMatch FMA:69074 semapv:UnspecifiedMatching
+CL:0002078 meso-epithelial cell semapv:crossSpeciesExactMatch ZFA:0009388 meso-epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002078 meso-epithelial cell semapv:crossSpeciesExactMatch FMA:69076 semapv:UnspecifiedMatching
+CL:0002079 pancreatic ductal cell semapv:crossSpeciesExactMatch ZFA:0009380 pancreatic ductal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002079 pancreatic ductal cell semapv:crossSpeciesExactMatch FMA:63099 semapv:UnspecifiedMatching
+CL:0002080 pancreatic centro-acinar cell semapv:crossSpeciesExactMatch ZFA:0005740 pancreatic centroacinar cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002080 pancreatic centro-acinar cell semapv:crossSpeciesExactMatch FMA:62455 semapv:UnspecifiedMatching
+CL:0002081 type II cell of carotid body semapv:crossSpeciesExactMatch FMA:84187 semapv:UnspecifiedMatching
+CL:0002082 type II cell of adrenal medulla semapv:crossSpeciesExactMatch FMA:69322 semapv:UnspecifiedMatching
+CL:0002083 type I cell of adrenal medulla semapv:crossSpeciesExactMatch FMA:69321 semapv:UnspecifiedMatching
+CL:0002085 tanycyte semapv:crossSpeciesExactMatch FMA:54560 semapv:UnspecifiedMatching
+CL:0002086 specialized cardiac myocyte semapv:crossSpeciesExactMatch FMA:67968 semapv:UnspecifiedMatching
+CL:0002087 nongranular leukocyte semapv:crossSpeciesExactMatch FMA:62855 semapv:UnspecifiedMatching
+CL:0002088 interstitial cell of Cajal semapv:crossSpeciesExactMatch FMA:86573 semapv:UnspecifiedMatching
+CL:0002090 polar body semapv:crossSpeciesExactMatch EHDAA2:0004716 semapv:UnspecifiedMatching
+CL:0002090 polar body semapv:crossSpeciesExactMatch WBbt:0008429 semapv:UnspecifiedMatching
+CL:0002090 polar body semapv:crossSpeciesExactMatch XAO:0000262 semapv:UnspecifiedMatching
+CL:0002090 polar body semapv:crossSpeciesExactMatch FMA:85543 semapv:UnspecifiedMatching
+CL:0002091 primary polar body skos:broadMatch VHOG:0000464 semapv:UnspecifiedMatching
+CL:0002091 primary polar body semapv:crossSpeciesExactMatch EHDAA2:0000541 semapv:UnspecifiedMatching
+CL:0002091 primary polar body semapv:crossSpeciesExactMatch EMAPA:16032 semapv:UnspecifiedMatching
+CL:0002091 primary polar body semapv:crossSpeciesExactMatch FMA:18650 semapv:UnspecifiedMatching
+CL:0002092 bone marrow cell semapv:crossSpeciesExactMatch FMA:83621 semapv:UnspecifiedMatching
+CL:0002093 secondary polar body semapv:crossSpeciesExactMatch EHDAA2:0001820 semapv:UnspecifiedMatching
+CL:0002093 secondary polar body semapv:crossSpeciesExactMatch EMAPA:16034 semapv:UnspecifiedMatching
+CL:0002093 secondary polar body semapv:crossSpeciesExactMatch EMAPA:16045 semapv:UnspecifiedMatching
+CL:0002093 secondary polar body semapv:crossSpeciesExactMatch FMA:18651 semapv:UnspecifiedMatching
+CL:0002094 interstitial cell of ovary semapv:crossSpeciesExactMatch FMA:18709 semapv:UnspecifiedMatching
+CL:0002095 hilus cell of ovary semapv:crossSpeciesExactMatch FMA:18710 semapv:UnspecifiedMatching
+CL:0002096 internodal tract myocyte semapv:crossSpeciesExactMatch FMA:223275 semapv:UnspecifiedMatching
+CL:0002097 cortical cell of adrenal gland semapv:crossSpeciesExactMatch FMA:69545 semapv:UnspecifiedMatching
+CL:0002098 regular cardiac myocyte semapv:crossSpeciesExactMatch FMA:67967 semapv:UnspecifiedMatching
+CL:0002099 type I cell of adrenal cortex semapv:crossSpeciesExactMatch FMA:69273 semapv:UnspecifiedMatching
+CL:0002100 regular interventricular cardiac myocyte semapv:crossSpeciesExactMatch FMA:228792 semapv:UnspecifiedMatching
+CL:0002129 regular atrial cardiac myocyte semapv:crossSpeciesExactMatch FMA:83108 semapv:UnspecifiedMatching
+CL:0002130 regular interatrial cardiac myocyte semapv:crossSpeciesExactMatch FMA:228790 semapv:UnspecifiedMatching
+CL:0002131 regular ventricular cardiac myocyte semapv:crossSpeciesExactMatch FMA:83109 semapv:UnspecifiedMatching
+CL:0002132 stromal cell of ovary semapv:crossSpeciesExactMatch FMA:72299 semapv:UnspecifiedMatching
+CL:0002133 stromal cell of ovarian cortex semapv:crossSpeciesExactMatch FMA:256169 semapv:UnspecifiedMatching
+CL:0002134 stromal cell of ovarian medulla semapv:crossSpeciesExactMatch FMA:256171 semapv:UnspecifiedMatching
+CL:0002135 nonkeratinized cell of epidermis semapv:crossSpeciesExactMatch FMA:62880 semapv:UnspecifiedMatching
+CL:0002136 type II cell of adrenal cortex semapv:crossSpeciesExactMatch FMA:69547 semapv:UnspecifiedMatching
+CL:0002137 type III cell of adrenal cortex semapv:crossSpeciesExactMatch FMA:69564 semapv:UnspecifiedMatching
+CL:0002138 endothelial cell of lymphatic vessel semapv:crossSpeciesExactMatch FMA:68458 semapv:UnspecifiedMatching
+CL:0002139 endothelial cell of vascular tree semapv:crossSpeciesExactMatch FMA:67755 semapv:UnspecifiedMatching
+CL:0002140 skin sebocyte semapv:crossSpeciesExactMatch FMA:70953 semapv:UnspecifiedMatching
+CL:0002141 active chief cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69082 semapv:UnspecifiedMatching
+CL:0002142 dark cell of eccrine sweat gland semapv:crossSpeciesExactMatch FMA:70659 semapv:UnspecifiedMatching
+CL:0002143 dark chief cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69080 semapv:UnspecifiedMatching
+CL:0002144 capillary endothelial cell semapv:crossSpeciesExactMatch FMA:67756 semapv:UnspecifiedMatching
+CL:0002145 multiciliated columnar cell of tracheobronchial tree semapv:crossSpeciesExactMatch FMA:70542 semapv:UnspecifiedMatching
+CL:0002146 clear cell of eccrine sweat gland semapv:crossSpeciesExactMatch FMA:70658 semapv:UnspecifiedMatching
+CL:0002147 clear chief cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69081 semapv:UnspecifiedMatching
+CL:0002148 dental pulp cell semapv:crossSpeciesExactMatch FMA:87170 semapv:UnspecifiedMatching
+CL:0002149 epithelial cell of uterus semapv:crossSpeciesExactMatch FMA:256161 semapv:UnspecifiedMatching
+CL:0002150 epithelioid macrophage semapv:crossSpeciesExactMatch FMA:83514 semapv:UnspecifiedMatching
+CL:0002151 late promyelocyte semapv:crossSpeciesExactMatch FMA:83534 semapv:UnspecifiedMatching
+CL:0002152 columnar cell of endocervix semapv:crossSpeciesExactMatch FMA:86486 semapv:UnspecifiedMatching
+CL:0002153 corneocyte semapv:crossSpeciesExactMatch FMA:68650 semapv:UnspecifiedMatching
+CL:0002154 early promyelocyte semapv:crossSpeciesExactMatch FMA:83533 semapv:UnspecifiedMatching
+CL:0002155 echinocyte semapv:crossSpeciesExactMatch FMA:81099 semapv:UnspecifiedMatching
+CL:0002157 endosteal cell semapv:crossSpeciesExactMatch FMA:86495 semapv:UnspecifiedMatching
+CL:0002158 external epithelial cell of tympanic membrane semapv:crossSpeciesExactMatch FMA:70558 semapv:UnspecifiedMatching
+CL:0002159 general ecto-epithelial cell semapv:crossSpeciesExactMatch FMA:70556 semapv:UnspecifiedMatching
+CL:0002162 internal epithelial cell of tympanic membrane semapv:crossSpeciesExactMatch FMA:70626 semapv:UnspecifiedMatching
+CL:0002163 internal pillar cell of cochlea semapv:crossSpeciesExactMatch FMA:75726 semapv:UnspecifiedMatching
+CL:0002164 external pillar cell of cochlea semapv:crossSpeciesExactMatch FMA:75727 semapv:UnspecifiedMatching
+CL:0002165 phalangeal cell semapv:crossSpeciesExactMatch FMA:79800 semapv:UnspecifiedMatching
+CL:0002166 epithelial cell of Malassez semapv:crossSpeciesExactMatch FMA:62987 semapv:UnspecifiedMatching
+CL:0002167 olfactory epithelial cell semapv:crossSpeciesExactMatch FMA:67870 semapv:UnspecifiedMatching
+CL:0002168 border cell of cochlea semapv:crossSpeciesExactMatch FMA:79798 semapv:UnspecifiedMatching
+CL:0002169 basal cell of olfactory epithelium semapv:crossSpeciesExactMatch FMA:62303 semapv:UnspecifiedMatching
+CL:0002171 globose cell of olfactory epithelium semapv:crossSpeciesExactMatch FMA:67874 semapv:UnspecifiedMatching
+CL:0002172 interdental cell of cochlea semapv:crossSpeciesExactMatch FMA:79797 semapv:UnspecifiedMatching
+CL:0002173 extraglomerular mesangial cell semapv:crossSpeciesExactMatch KUPO:0001033 semapv:UnspecifiedMatching
+CL:0002173 extraglomerular mesangial cell semapv:crossSpeciesExactMatch FMA:84143 semapv:UnspecifiedMatching
+CL:0002174 follicular cell of ovary semapv:crossSpeciesExactMatch EMAPA:31247 semapv:UnspecifiedMatching
+CL:0002174 follicular cell of ovary semapv:crossSpeciesExactMatch FMA:70589 semapv:UnspecifiedMatching
+CL:0002175 primary follicular cell of ovary semapv:crossSpeciesExactMatch FMA:70590 semapv:UnspecifiedMatching
+CL:0002176 secondary follicular cell of ovary semapv:crossSpeciesExactMatch FMA:70591 semapv:UnspecifiedMatching
+CL:0002177 folliculostellate cell of pars distalis of adenohypophysis semapv:crossSpeciesExactMatch FMA:83102 semapv:UnspecifiedMatching
+CL:0002178 epithelial cell of stomach semapv:crossSpeciesExactMatch FMA:62948 semapv:UnspecifiedMatching
+CL:0002179 foveolar cell of stomach semapv:crossSpeciesExactMatch FMA:62949 semapv:UnspecifiedMatching
+CL:0002179 foveolar cell of stomach semapv:crossSpeciesExactMatch FMA:86552 semapv:UnspecifiedMatching
+CL:0002180 mucous cell of stomach semapv:crossSpeciesExactMatch FMA:63464 semapv:UnspecifiedMatching
+CL:0002181 mucous neck cell of gastric gland semapv:crossSpeciesExactMatch FMA:62954 semapv:UnspecifiedMatching
+CL:0002183 stem cell of gastric gland semapv:crossSpeciesExactMatch FMA:62953 semapv:UnspecifiedMatching
+CL:0002184 basal proper cell of olfactory epithelium semapv:crossSpeciesExactMatch FMA:62304 semapv:UnspecifiedMatching
+CL:0002187 basal cell of epidermis semapv:crossSpeciesExactMatch FMA:70571 semapv:UnspecifiedMatching
+CL:0002188 glomerular endothelial cell semapv:crossSpeciesExactMatch FMA:70970 semapv:UnspecifiedMatching
+CL:0002189 granular cell of epidermis semapv:crossSpeciesExactMatch FMA:70543 semapv:UnspecifiedMatching
+CL:0002190 squamous cell of epidermis semapv:crossSpeciesExactMatch FMA:86925 semapv:UnspecifiedMatching
+CL:0002191 granulocytopoietic cell semapv:crossSpeciesExactMatch FMA:83519 semapv:UnspecifiedMatching
+CL:0002192 metamyelocyte semapv:crossSpeciesExactMatch FMA:83541 semapv:UnspecifiedMatching
+CL:0002193 myelocyte semapv:crossSpeciesExactMatch FMA:83525 semapv:UnspecifiedMatching
+CL:0002194 monopoietic cell semapv:crossSpeciesExactMatch FMA:83552 semapv:UnspecifiedMatching
+CL:0002195 hepatic stem cell semapv:crossSpeciesExactMatch FMA:86577 semapv:UnspecifiedMatching
+CL:0002196 hepatic oval stem cell semapv:crossSpeciesExactMatch FMA:86576 semapv:UnspecifiedMatching
+CL:0002198 oncocyte semapv:crossSpeciesExactMatch FMA:67606 semapv:UnspecifiedMatching
+CL:0002199 oxyphil cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69084 semapv:UnspecifiedMatching
+CL:0002200 oxyphil cell of thyroid semapv:crossSpeciesExactMatch FMA:87169 semapv:UnspecifiedMatching
+CL:0002202 epithelial cell of tracheobronchial tree semapv:crossSpeciesExactMatch FMA:66816 semapv:UnspecifiedMatching
+CL:0002203 brush cell of epithelium proper of large intestine semapv:crossSpeciesExactMatch FMA:263222 semapv:UnspecifiedMatching
+CL:0002204 brush cell semapv:crossSpeciesExactMatch FMA:67978 semapv:UnspecifiedMatching
+CL:0002205 brush cell of lobular bronchiole semapv:crossSpeciesExactMatch FMA:263220 semapv:UnspecifiedMatching
+CL:0002206 brush cell of terminal bronchiole semapv:crossSpeciesExactMatch FMA:263228 semapv:UnspecifiedMatching
+CL:0002207 brush cell of trachea semapv:crossSpeciesExactMatch FMA:263224 semapv:UnspecifiedMatching
+CL:0002208 brush cell of bronchus semapv:crossSpeciesExactMatch FMA:263226 semapv:UnspecifiedMatching
+CL:0002209 intermediate epitheliocyte semapv:crossSpeciesExactMatch FMA:69060 semapv:UnspecifiedMatching
+CL:0002210 red muscle cell semapv:crossSpeciesExactMatch FMA:84448 semapv:UnspecifiedMatching
+CL:0002211 type I muscle cell semapv:crossSpeciesExactMatch FMA:84413 semapv:UnspecifiedMatching
+CL:0002212 type II muscle cell semapv:crossSpeciesExactMatch FMA:84414 semapv:UnspecifiedMatching
+CL:0002213 white muscle cell semapv:crossSpeciesExactMatch FMA:84449 semapv:UnspecifiedMatching
+CL:0002214 type IIa muscle cell semapv:crossSpeciesExactMatch FMA:84415 semapv:UnspecifiedMatching
+CL:0002215 type IIb muscle cell semapv:crossSpeciesExactMatch FMA:84416 semapv:UnspecifiedMatching
+CL:0002216 intermediate muscle cell semapv:crossSpeciesExactMatch FMA:84450 semapv:UnspecifiedMatching
+CL:0002217 intermediate trophoblast cell semapv:crossSpeciesExactMatch FMA:86564 semapv:UnspecifiedMatching
+CL:0002220 interstitial cell of pineal gland semapv:crossSpeciesExactMatch FMA:86575 semapv:UnspecifiedMatching
+CL:0002221 keratinized squamous cell of esophagus semapv:crossSpeciesExactMatch FMA:86549 semapv:UnspecifiedMatching
+CL:0002222 vertebrate lens cell semapv:crossSpeciesExactMatch FMA:70950 semapv:UnspecifiedMatching
+CL:0002223 anterior lens cell semapv:crossSpeciesExactMatch FMA:63181 semapv:UnspecifiedMatching
+CL:0002224 lens epithelial cell semapv:crossSpeciesExactMatch FMA:67559 semapv:UnspecifiedMatching
+CL:0002226 non-nucleated secondary lens fiber semapv:crossSpeciesExactMatch FMA:67561 semapv:UnspecifiedMatching
+CL:0002227 nucleated secondary lens fiber semapv:crossSpeciesExactMatch FMA:70949 semapv:UnspecifiedMatching
+CL:0002228 primary lens fiber semapv:crossSpeciesExactMatch FMA:70613 semapv:UnspecifiedMatching
+CL:0002229 light chief cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69079 semapv:UnspecifiedMatching
+CL:0002231 epithelial cell of prostate semapv:crossSpeciesExactMatch FMA:256163 semapv:UnspecifiedMatching
+CL:0002231 epithelial cell of prostate semapv:crossSpeciesExactMatch FMA:66817 semapv:UnspecifiedMatching
+CL:0002232 epithelial cell of prostatic duct semapv:crossSpeciesExactMatch FMA:74224 semapv:UnspecifiedMatching
+CL:0002233 epithelial cell of prostatic acinus semapv:crossSpeciesExactMatch FMA:74223 semapv:UnspecifiedMatching
+CL:0002234 basal cell of prostatic acinus semapv:crossSpeciesExactMatch FMA:74265 semapv:UnspecifiedMatching
+CL:0002235 luminal cell of prostatic acinus semapv:crossSpeciesExactMatch FMA:74266 semapv:UnspecifiedMatching
+CL:0002236 basal epithelial cell of prostatic duct semapv:crossSpeciesExactMatch FMA:74226 semapv:UnspecifiedMatching
+CL:0002237 luminal epithelial cell of prostatic duct semapv:crossSpeciesExactMatch FMA:74225 semapv:UnspecifiedMatching
+CL:0002238 male gonocyte skos:broadMatch VHOG:0000662 semapv:UnspecifiedMatching
+CL:0002238 male gonocyte semapv:crossSpeciesExactMatch EHDAA2:0001053 semapv:UnspecifiedMatching
+CL:0002238 male gonocyte semapv:crossSpeciesExactMatch EMAPA:18686 semapv:UnspecifiedMatching
+CL:0002238 male gonocyte semapv:crossSpeciesExactMatch FMA:84771 semapv:UnspecifiedMatching
+CL:0002239 ooblast skos:broadMatch VHOG:0000661 semapv:UnspecifiedMatching
+CL:0002239 ooblast semapv:crossSpeciesExactMatch EHDAA2:0000505 semapv:UnspecifiedMatching
+CL:0002239 ooblast semapv:crossSpeciesExactMatch EMAPA:17965 semapv:UnspecifiedMatching
+CL:0002239 ooblast semapv:crossSpeciesExactMatch FMA:84772 semapv:UnspecifiedMatching
+CL:0002240 marrow fibroblast semapv:crossSpeciesExactMatch FMA:84377 semapv:UnspecifiedMatching
+CL:0002241 pulmonary interstitial fibroblast semapv:crossSpeciesExactMatch FMA:84467 semapv:UnspecifiedMatching
+CL:0002242 nucleate cell semapv:crossSpeciesExactMatch FMA:67513 semapv:UnspecifiedMatching
+CL:0002243 smooth muscle cell of sphincter of pupil semapv:crossSpeciesExactMatch FMA:70611 semapv:UnspecifiedMatching
+CL:0002244 squamous cell of ectocervix semapv:crossSpeciesExactMatch FMA:86483 semapv:UnspecifiedMatching
+CL:0002246 peripheral blood stem cell semapv:crossSpeciesExactMatch FMA:86711 semapv:UnspecifiedMatching
+CL:0002247 pleural macrophage semapv:crossSpeciesExactMatch FMA:83024 semapv:UnspecifiedMatching
+CL:0002248 pluripotent stem cell semapv:crossSpeciesExactMatch FMA:70570 semapv:UnspecifiedMatching
+CL:0002249 primitive cardiac myocyte semapv:crossSpeciesExactMatch FMA:75620 semapv:UnspecifiedMatching
+CL:0002250 intestinal crypt stem cell semapv:crossSpeciesExactMatch FMA:63379 semapv:UnspecifiedMatching
+CL:0002252 epithelial cell of esophagus semapv:crossSpeciesExactMatch ZFA:0009400 epithelial cell of esophagus semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002252 epithelial cell of esophagus semapv:crossSpeciesExactMatch FMA:63071 semapv:UnspecifiedMatching
+CL:0002253 epithelial cell of large intestine semapv:crossSpeciesExactMatch FMA:256157 semapv:UnspecifiedMatching
+CL:0002254 epithelial cell of small intestine semapv:crossSpeciesExactMatch FMA:256159 semapv:UnspecifiedMatching
+CL:0002255 stromal cell of endometrium semapv:crossSpeciesExactMatch FMA:86490 semapv:UnspecifiedMatching
+CL:0002256 supporting cell of carotid body semapv:crossSpeciesExactMatch FMA:84188 semapv:UnspecifiedMatching
+CL:0002257 epithelial cell of thyroid gland semapv:crossSpeciesExactMatch FMA:256167 semapv:UnspecifiedMatching
+CL:0002258 thyroid follicular cell semapv:crossSpeciesExactMatch FMA:68782 semapv:UnspecifiedMatching
+CL:0002259 neuroepithelial stem cell semapv:crossSpeciesExactMatch FMA:87171 semapv:UnspecifiedMatching
+CL:0002260 epithelial cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:70547 semapv:UnspecifiedMatching
+CL:0002261 endothelial cell of viscerocranial mucosa semapv:crossSpeciesExactMatch FMA:70627 semapv:UnspecifiedMatching
+CL:0002262 endothelial cell of sinusoid semapv:crossSpeciesExactMatch FMA:63134 semapv:UnspecifiedMatching
+CL:0002263 transitional cell of parathyroid gland semapv:crossSpeciesExactMatch FMA:69324 semapv:UnspecifiedMatching
+CL:0002264 type A cell of stomach semapv:crossSpeciesExactMatch FMA:83411 semapv:UnspecifiedMatching
+CL:0002265 type D cell of colon semapv:crossSpeciesExactMatch FMA:268744 semapv:UnspecifiedMatching
+CL:0002266 type D cell of small intestine semapv:crossSpeciesExactMatch FMA:268736 semapv:UnspecifiedMatching
+CL:0002267 type D cell of stomach semapv:crossSpeciesExactMatch FMA:83410 semapv:UnspecifiedMatching
+CL:0002268 P/D1 enteroendocrine cell semapv:crossSpeciesExactMatch FMA:63418 semapv:UnspecifiedMatching
+CL:0002270 type EC2 enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62941 semapv:UnspecifiedMatching
+CL:0002271 type EC1 enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62940 semapv:UnspecifiedMatching
+CL:0002273 type ECL enteroendocrine cell semapv:crossSpeciesExactMatch FMA:63208 semapv:UnspecifiedMatching
+CL:0002275 pancreatic PP cell semapv:crossSpeciesExactMatch ZFA:0005742 pancreatic PP cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002275 pancreatic PP cell semapv:crossSpeciesExactMatch FMA:70588 semapv:UnspecifiedMatching
+CL:0002277 type I enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62937 semapv:UnspecifiedMatching
+CL:0002278 GIP cell semapv:crossSpeciesExactMatch FMA:62942 semapv:UnspecifiedMatching
+CL:0002279 type L enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62944 semapv:UnspecifiedMatching
+CL:0002280 type N enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62943 semapv:UnspecifiedMatching
+CL:0002281 type S enteroendocrine cell semapv:crossSpeciesExactMatch FMA:62936 semapv:UnspecifiedMatching
+CL:0002282 type TG enteroendocrine cell semapv:crossSpeciesExactMatch FMA:63421 semapv:UnspecifiedMatching
+CL:0002283 ecto-epithelial cell of viscerocranial mucosa semapv:crossSpeciesExactMatch FMA:70581 semapv:UnspecifiedMatching
+CL:0002284 type X enteroendocrine cell semapv:crossSpeciesExactMatch FMA:63209 semapv:UnspecifiedMatching
+CL:0002285 type III taste bud cell semapv:crossSpeciesExactMatch FMA:67940 semapv:UnspecifiedMatching
+CL:0002286 type II taste cell semapv:crossSpeciesExactMatch FMA:62381 semapv:UnspecifiedMatching
+CL:0002287 type IV taste receptor cell semapv:crossSpeciesExactMatch FMA:62380 semapv:UnspecifiedMatching
+CL:0002288 type V taste receptor cell semapv:crossSpeciesExactMatch FMA:67941 semapv:UnspecifiedMatching
+CL:0002289 type I taste bud cell semapv:crossSpeciesExactMatch FMA:62356 semapv:UnspecifiedMatching
+CL:0002290 Y chromosome-bearing sperm cell semapv:crossSpeciesExactMatch FMA:84058 semapv:UnspecifiedMatching
+CL:0002291 X chromosome-bearing sperm cell semapv:crossSpeciesExactMatch FMA:84057 semapv:UnspecifiedMatching
+CL:0002292 type I cell of carotid body semapv:crossSpeciesExactMatch FMA:84186 semapv:UnspecifiedMatching
+CL:0002293 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72208 semapv:UnspecifiedMatching
+CL:0002294 type-1 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72209 semapv:UnspecifiedMatching
+CL:0002295 type-6 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72214 semapv:UnspecifiedMatching
+CL:0002296 type-4 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72212 semapv:UnspecifiedMatching
+CL:0002297 type-3 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72211 semapv:UnspecifiedMatching
+CL:0002298 type-5 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72213 semapv:UnspecifiedMatching
+CL:0002299 type-2 epithelial cell of thymus semapv:crossSpeciesExactMatch FMA:72210 semapv:UnspecifiedMatching
+CL:0002301 type B synovial cell semapv:crossSpeciesExactMatch FMA:66788 semapv:UnspecifiedMatching
+CL:0002302 type A synovial cell semapv:crossSpeciesExactMatch FMA:66787 semapv:UnspecifiedMatching
+CL:0002303 pigmented ciliary epithelial cell semapv:crossSpeciesExactMatch FMA:70606 semapv:UnspecifiedMatching
+CL:0002304 non-pigmented ciliary epithelial cell semapv:crossSpeciesExactMatch FMA:70607 semapv:UnspecifiedMatching
+CL:0002305 epithelial cell of distal tubule semapv:crossSpeciesExactMatch KUPO:0001055 semapv:UnspecifiedMatching
+CL:0002305 epithelial cell of distal tubule semapv:crossSpeciesExactMatch FMA:70981 semapv:UnspecifiedMatching
+CL:0002306 epithelial cell of proximal tubule semapv:crossSpeciesExactMatch KUPO:0001044 semapv:UnspecifiedMatching
+CL:0002306 epithelial cell of proximal tubule semapv:crossSpeciesExactMatch FMA:70973 semapv:UnspecifiedMatching
+CL:0002308 epithelial cell of skin gland semapv:crossSpeciesExactMatch FMA:70657 semapv:UnspecifiedMatching
+CL:0002309 corticotroph semapv:crossSpeciesExactMatch FMA:83098 semapv:UnspecifiedMatching
+CL:0002310 mammosomatotroph semapv:crossSpeciesExactMatch FMA:83097 semapv:UnspecifiedMatching
+CL:0002311 mammotroph semapv:crossSpeciesExactMatch FMA:83096 semapv:UnspecifiedMatching
+CL:0002312 somatotroph semapv:crossSpeciesExactMatch FMA:83095 semapv:UnspecifiedMatching
+CL:0002313 endocrine-paracrine cell of prostate gland semapv:crossSpeciesExactMatch FMA:74390 semapv:UnspecifiedMatching
+CL:0002313 endocrine-paracrine cell of prostate gland semapv:crossSpeciesExactMatch FMA:86774 semapv:UnspecifiedMatching
+CL:0002314 external supporting cell of vestibular epithelium semapv:crossSpeciesExactMatch FMA:75809 semapv:UnspecifiedMatching
+CL:0002315 supporting cell of cochlea semapv:crossSpeciesExactMatch FMA:79796 semapv:UnspecifiedMatching
+CL:0002316 supporting cell of vestibular epithelium semapv:crossSpeciesExactMatch FMA:75607 semapv:UnspecifiedMatching
+CL:0002317 external limiting cell of vestibular epithelium semapv:crossSpeciesExactMatch FMA:75808 semapv:UnspecifiedMatching
+CL:0002318 peripheral blood mesothelial cell semapv:crossSpeciesExactMatch FMA:86712 semapv:UnspecifiedMatching
+CL:0002319 neural cell semapv:crossSpeciesExactMatch FMA:70333 semapv:UnspecifiedMatching
+CL:0002320 connective tissue cell semapv:crossSpeciesExactMatch ZFA:0009392 connective tissue cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002320 connective tissue cell semapv:crossSpeciesExactMatch FMA:63875 semapv:UnspecifiedMatching
+CL:0002321 embryonic cell (metazoa) semapv:crossSpeciesExactMatch WBbt:0007028 semapv:UnspecifiedMatching
+CL:0002321 embryonic cell (metazoa) semapv:crossSpeciesExactMatch ZFA:0007089 embryonic cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002321 embryonic cell (metazoa) semapv:crossSpeciesExactMatch FMA:82840 semapv:UnspecifiedMatching
+CL:0002322 embryonic stem cell semapv:crossSpeciesExactMatch FMA:82841 semapv:UnspecifiedMatching
+CL:0002324 basal-myoepithelial cell of mammary gland semapv:crossSpeciesExactMatch FMA:67800 semapv:UnspecifiedMatching
+CL:0002325 lactocyte semapv:crossSpeciesExactMatch FMA:74506 semapv:UnspecifiedMatching
+CL:0002325 lactocyte semapv:crossSpeciesExactMatch FMA:79866 semapv:UnspecifiedMatching
+CL:0002326 luminal epithelial cell of mammary gland semapv:crossSpeciesExactMatch FMA:73280 semapv:UnspecifiedMatching
+CL:0002350 endocardial cell semapv:crossSpeciesExactMatch FMA:75621 semapv:UnspecifiedMatching
+CL:0002372 myotube semapv:crossSpeciesExactMatch FBbt:00005812 myotube semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0002377 immature Schwann cell semapv:crossSpeciesExactMatch ZFA:0001725 semapv:UnspecifiedMatching
+CL:0002377 immature Schwann cell semapv:crossSpeciesExactMatch ZFA:0001725 immature Schwann cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002379 meningothelial cell semapv:crossSpeciesExactMatch FMA:86588 semapv:UnspecifiedMatching
+CL:0002422 enucleated reticulocyte semapv:crossSpeciesExactMatch FMA:66785 semapv:UnspecifiedMatching
+CL:0002450 tether cell semapv:crossSpeciesExactMatch ZFA:0005565 tether cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002494 cardiocyte semapv:crossSpeciesExactMatch FMA:83808 semapv:UnspecifiedMatching
+CL:0002494 cardiocyte semapv:crossSpeciesExactMatch FMA:84791 semapv:UnspecifiedMatching
+CL:0002497 primary trophoblast giant cell semapv:crossSpeciesExactMatch EMAPA:16066 semapv:UnspecifiedMatching
+CL:0002501 type D1 enteroendocrine cell semapv:crossSpeciesExactMatch FMA:63207 semapv:UnspecifiedMatching
+CL:0002502 type M enteroendocrine cell semapv:crossSpeciesExactMatch FMA:63420 semapv:UnspecifiedMatching
+CL:0002503 adventitial cell semapv:crossSpeciesExactMatch FMA:84639 semapv:UnspecifiedMatching
+CL:0002518 kidney epithelial cell semapv:crossSpeciesExactMatch KUPO:0001019 semapv:UnspecifiedMatching
+CL:0002518 kidney epithelial cell semapv:crossSpeciesExactMatch ZFA:0009374 kidney epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002538 intrahepatic cholangiocyte semapv:crossSpeciesExactMatch ZFA:0009379 intrahepatic bile duct epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002543 vein endothelial cell semapv:crossSpeciesExactMatch KUPO:0001099 semapv:UnspecifiedMatching
+CL:0002543 vein endothelial cell semapv:crossSpeciesExactMatch FMA:62104 semapv:UnspecifiedMatching
+CL:0002546 embryonic blood vessel endothelial progenitor cell semapv:crossSpeciesExactMatch ZFA:0005773 embryonic blood vessel endothelial progenitor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002563 intestinal epithelial cell semapv:crossSpeciesExactMatch ZFA:0009399 intestinal epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0002584 renal cortical epithelial cell semapv:crossSpeciesExactMatch KUPO:0001016 semapv:UnspecifiedMatching
+CL:0002586 retinal pigment epithelial cell semapv:crossSpeciesExactMatch FMA:75802 semapv:UnspecifiedMatching
+CL:0002597 smooth muscle cell of bladder semapv:crossSpeciesExactMatch KUPO:0001122 semapv:UnspecifiedMatching
+CL:0002635 nonkeratinized epithelial cell of anal column semapv:crossSpeciesExactMatch FMA:263146 semapv:UnspecifiedMatching
+CL:0002636 nonkeratinized epithelial cell of inferior part of anal canal semapv:crossSpeciesExactMatch FMA:263144 semapv:UnspecifiedMatching
+CL:0002641 epithelial cell of esophageal gland proper semapv:crossSpeciesExactMatch FMA:256141 semapv:UnspecifiedMatching
+CL:0002642 epithelial cell of esophageal cardiac gland semapv:crossSpeciesExactMatch FMA:256143 semapv:UnspecifiedMatching
+CL:0002643 nonkeratinized cell of stratum corneum of esophageal epithelium semapv:crossSpeciesExactMatch FMA:263148 semapv:UnspecifiedMatching
+CL:0002644 endo-epithelial cell of tympanic part of viscerocranial mucosa semapv:crossSpeciesExactMatch FMA:70628 semapv:UnspecifiedMatching
+CL:0002645 endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa semapv:crossSpeciesExactMatch FMA:70629 semapv:UnspecifiedMatching
+CL:0002651 endothelial cell of venous sinus of spleen semapv:crossSpeciesExactMatch FMA:72140 semapv:UnspecifiedMatching
+CL:0002652 endothelial cell of high endothelial venule semapv:crossSpeciesExactMatch FMA:67759 semapv:UnspecifiedMatching
+CL:0002654 epithelial cell of stratum corneum of esophageal epithelium semapv:crossSpeciesExactMatch FMA:70733 semapv:UnspecifiedMatching
+CL:0002655 epithelial cell of stratum spinosum of esophageal epithelium semapv:crossSpeciesExactMatch FMA:70732 semapv:UnspecifiedMatching
+CL:0002656 glandular endometrial unciliated epithelial cell semapv:crossSpeciesExactMatch FMA:86489 semapv:UnspecifiedMatching
+CL:0002657 glandular cell of esophagus semapv:crossSpeciesExactMatch FMA:86548 semapv:UnspecifiedMatching
+CL:0002658 glandular cell of the large intestine semapv:crossSpeciesExactMatch FMA:87194 semapv:UnspecifiedMatching
+CL:0002659 glandular epithelial cell of stomach semapv:crossSpeciesExactMatch FMA:86554 semapv:UnspecifiedMatching
+CL:0002660 luminal cell of acinus of lactiferous gland semapv:crossSpeciesExactMatch FMA:74505 semapv:UnspecifiedMatching
+CL:0002661 luminal cell of lactiferous terminal ductal lobular unit semapv:crossSpeciesExactMatch FMA:87168 semapv:UnspecifiedMatching
+CL:0002662 luminal cell of lactiferous duct semapv:crossSpeciesExactMatch FMA:74504 semapv:UnspecifiedMatching
+CL:0002663 myocardial endocrine cell of atrium semapv:crossSpeciesExactMatch FMA:83389 semapv:UnspecifiedMatching
+CL:0005000 spinal cord interneuron semapv:crossSpeciesExactMatch ZFA:0000778 spinal cord interneuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005001 iridoblast semapv:crossSpeciesExactMatch ZFA:0005328 iridoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005002 xanthoblast semapv:crossSpeciesExactMatch ZFA:0005245 xanthoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005003 leucoblast semapv:crossSpeciesExactMatch ZFA:0005329 leucoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005004 pigment erythroblast semapv:crossSpeciesExactMatch ZFA:0005331 pigment erythroblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005005 cyanoblast semapv:crossSpeciesExactMatch ZFA:0005332 cyanoblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005006 ionocyte semapv:crossSpeciesExactMatch ZFA:0005323 ionocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005007 Kolmer-Agduhr neuron semapv:crossSpeciesExactMatch ZFA:0005240 Kolmer-Agduhr neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005009 renal principal cell semapv:crossSpeciesExactMatch ZFA:0005322 renal principal cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005010 renal intercalated cell semapv:crossSpeciesExactMatch ZFA:0009375 renal intercalated cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005010 renal intercalated cell semapv:crossSpeciesExactMatch FMA:86560 semapv:UnspecifiedMatching
+CL:0005011 renal alpha-intercalated cell semapv:crossSpeciesExactMatch ZFA:0009376 renal alpha-intercalated cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005012 multiciliated epithelial cell semapv:crossSpeciesExactMatch ZFA:0005242 multi-ciliated epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005013 single ciliated epithelial cell semapv:crossSpeciesExactMatch ZFA:0005243 single ciliated epithelial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005014 auditory epithelial supporting cell semapv:crossSpeciesExactMatch ZFA:0005244 auditory epithelial support cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005015 inner phalangeal cell semapv:crossSpeciesExactMatch FMA:79801 semapv:UnspecifiedMatching
+CL:0005018 ghrelin secreting cell semapv:crossSpeciesExactMatch ZFA:0005599 ghrelin secreting cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005019 pancreatic epsilon cell semapv:crossSpeciesExactMatch ZFA:0005598 pancreatic epsilon cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005020 lymphangioblast semapv:crossSpeciesExactMatch ZFA:0009393 lymphangioblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005021 mesenchymal lymphangioblast semapv:crossSpeciesExactMatch ZFA:0009394 mesenchymal lymphangioblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005022 vascular lymphangioblast semapv:crossSpeciesExactMatch ZFA:0009395 vascular lymphangioblast semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005023 branchiomotor neuron semapv:crossSpeciesExactMatch ZFA:0005731 branchiomotor neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005024 somatomotor neuron semapv:crossSpeciesExactMatch ZFA:0005733 somatomotor neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0005025 visceromotor neuron semapv:crossSpeciesExactMatch ZFA:0005732 visceromotor neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0007004 premigratory neural crest cell semapv:crossSpeciesExactMatch ZFA:0007084 premigratory neural crest cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0007007 notochordal sheath cell semapv:crossSpeciesExactMatch ZFA:0005744 notochord outer sheath cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0007011 enteric neuron semapv:crossSpeciesExactMatch ZFA:0005775 enteric neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0007016 adaxial cell semapv:crossSpeciesExactMatch ZFA:0000003 adaxial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0007022 micropylar cell semapv:crossSpeciesExactMatch ZFA:0005239 micropylar cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0008004 somatic muscle cell semapv:crossSpeciesExactMatch FBbt:00005073 somatic muscle cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0008007 visceral muscle cell semapv:crossSpeciesExactMatch FBbt:00005070 visceral muscle cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0008025 noradrenergic neuron semapv:crossSpeciesExactMatch ZFA:0005873 noradrenergic neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0008026 open tracheal system tracheocyte semapv:crossSpeciesExactMatch FBbt:00005038 tracheocyte semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0008034 mural cell semapv:crossSpeciesExactMatch ZFA:0005944 mural cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0008037 gamma motor neuron semapv:crossSpeciesExactMatch FMA:83660 semapv:UnspecifiedMatching
+CL:0008039 lower motor neuron semapv:crossSpeciesExactMatch FMA:84632 semapv:UnspecifiedMatching
+CL:0010012 cerebral cortex neuron semapv:crossSpeciesExactMatch FMA:84104 semapv:UnspecifiedMatching
+CL:0011004 lens fiber cell semapv:crossSpeciesExactMatch ZFA:0009401 lens fiber cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:0011102 parasympathetic neuron semapv:crossSpeciesExactMatch ZFA:0005776 parasympathetic neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0011103 sympathetic neuron semapv:crossSpeciesExactMatch ZFA:0005777 sympathetic neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0011109 hypocretin-secreting neuron semapv:crossSpeciesExactMatch ZFA:0005778 hypocretin-secreting neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0011110 histaminergic neuron semapv:crossSpeciesExactMatch FBbt:00007367 histaminergic neuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:0015000 cranial motor neuron semapv:crossSpeciesExactMatch ZFA:0005730 cranial motor neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:0017005 lymphoblast semapv:crossSpeciesExactMatch FMA:83030 semapv:UnspecifiedMatching
+CL:0017006 B-lymphoblast semapv:crossSpeciesExactMatch FMA:83031 semapv:UnspecifiedMatching
+CL:1000082 stretch receptor cell semapv:crossSpeciesExactMatch ZFA:0009370 stretch receptor cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:1000083 stratified keratinized epithelial stem cell semapv:crossSpeciesExactMatch ZFA:0009371 stratified keratinized epithelial stem cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:1000147 cardiac valve cell semapv:crossSpeciesExactMatch ZFA:0009402 heart valve cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:1000155 Malpighian tubule stellate cell semapv:crossSpeciesExactMatch FBbt:00005797 Malpighian tubule Type II cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:1000191 pillar cell semapv:crossSpeciesExactMatch FMA:75722 semapv:UnspecifiedMatching
+CL:1000275 smooth muscle cell of small intestine semapv:crossSpeciesExactMatch FMA:15050 semapv:UnspecifiedMatching
+CL:1000276 smooth muscle fiber of duodenum semapv:crossSpeciesExactMatch FMA:15058 semapv:UnspecifiedMatching
+CL:1000277 smooth muscle fiber of jejunum semapv:crossSpeciesExactMatch FMA:15062 semapv:UnspecifiedMatching
+CL:1000278 smooth muscle fiber of ileum semapv:crossSpeciesExactMatch FMA:15066 semapv:UnspecifiedMatching
+CL:1000279 smooth muscle cell of large intestine semapv:crossSpeciesExactMatch FMA:15653 semapv:UnspecifiedMatching
+CL:1000280 smooth muscle cell of colon semapv:crossSpeciesExactMatch FMA:15663 semapv:UnspecifiedMatching
+CL:1000281 smooth muscle cell of cecum semapv:crossSpeciesExactMatch FMA:15681 semapv:UnspecifiedMatching
+CL:1000282 smooth muscle fiber of ascending colon semapv:crossSpeciesExactMatch FMA:17518 semapv:UnspecifiedMatching
+CL:1000283 smooth muscle fiber of transverse colon semapv:crossSpeciesExactMatch FMA:17519 semapv:UnspecifiedMatching
+CL:1000284 smooth muscle fiber of descending colon semapv:crossSpeciesExactMatch FMA:17520 semapv:UnspecifiedMatching
+CL:1000285 smooth muscle cell of sigmoid colon semapv:crossSpeciesExactMatch FMA:17521 semapv:UnspecifiedMatching
+CL:1000286 smooth muscle cell of rectum semapv:crossSpeciesExactMatch FMA:17522 semapv:UnspecifiedMatching
+CL:1000287 myocyte of anterior internodal tract semapv:crossSpeciesExactMatch FMA:223276 semapv:UnspecifiedMatching
+CL:1000288 myocyte of atrial branch of anterior internodal tract semapv:crossSpeciesExactMatch FMA:223277 semapv:UnspecifiedMatching
+CL:1000289 myocyte of atrial septal branch of anterior internodal tract semapv:crossSpeciesExactMatch FMA:223278 semapv:UnspecifiedMatching
+CL:1000290 myocyte of middle internodal tract semapv:crossSpeciesExactMatch FMA:223279 semapv:UnspecifiedMatching
+CL:1000291 myocyte of posterior internodal tract semapv:crossSpeciesExactMatch FMA:223280 semapv:UnspecifiedMatching
+CL:1000296 epithelial cell of urethra semapv:crossSpeciesExactMatch FMA:256165 semapv:UnspecifiedMatching
+CL:1000298 mesothelial cell of dura mater semapv:crossSpeciesExactMatch FMA:256516 semapv:UnspecifiedMatching
+CL:1000299 fibroblast of connective tissue of prostate semapv:crossSpeciesExactMatch FMA:261271 semapv:UnspecifiedMatching
+CL:1000300 fibroblast of outer membrane of prostatic capsule semapv:crossSpeciesExactMatch FMA:261273 semapv:UnspecifiedMatching
+CL:1000301 fibroblast of subepithelial connective tissue of prostatic gland semapv:crossSpeciesExactMatch FMA:261275 semapv:UnspecifiedMatching
+CL:1000302 fibroblast of papillary layer of dermis semapv:crossSpeciesExactMatch FMA:261277 semapv:UnspecifiedMatching
+CL:1000303 fibroblast of areolar connective tissue semapv:crossSpeciesExactMatch FMA:261279 semapv:UnspecifiedMatching
+CL:1000304 fibroblast of connective tissue of nonglandular part of prostate semapv:crossSpeciesExactMatch FMA:261281 semapv:UnspecifiedMatching
+CL:1000305 fibroblast of connective tissue of glandular part of prostate semapv:crossSpeciesExactMatch FMA:261283 semapv:UnspecifiedMatching
+CL:1000306 fibroblast of tunica adventitia of artery semapv:crossSpeciesExactMatch FMA:261285 semapv:UnspecifiedMatching
+CL:1000307 fibroblast of dense regular elastic tissue semapv:crossSpeciesExactMatch FMA:261287 semapv:UnspecifiedMatching
+CL:1000308 fibrocyte of adventitia of ureter semapv:crossSpeciesExactMatch FMA:261289 semapv:UnspecifiedMatching
+CL:1000309 epicardial adipocyte semapv:crossSpeciesExactMatch FMA:261293 semapv:UnspecifiedMatching
+CL:1000310 adipocyte of epicardial fat of right ventricle semapv:crossSpeciesExactMatch FMA:261297 semapv:UnspecifiedMatching
+CL:1000311 adipocyte of epicardial fat of left ventricle semapv:crossSpeciesExactMatch FMA:261300 semapv:UnspecifiedMatching
+CL:1000312 bronchial goblet cell semapv:crossSpeciesExactMatch FMA:263032 semapv:UnspecifiedMatching
+CL:1000313 gastric goblet cell semapv:crossSpeciesExactMatch FMA:263035 semapv:UnspecifiedMatching
+CL:1000314 gastric cardiac gland goblet cell semapv:crossSpeciesExactMatch FMA:263038 semapv:UnspecifiedMatching
+CL:1000315 principal gastric gland goblet cell semapv:crossSpeciesExactMatch FMA:263040 semapv:UnspecifiedMatching
+CL:1000317 intestinal villus goblet cell semapv:crossSpeciesExactMatch FMA:263046 semapv:UnspecifiedMatching
+CL:1000320 large intestine goblet cell semapv:crossSpeciesExactMatch FMA:263054 semapv:UnspecifiedMatching
+CL:1000321 large intestine crypt goblet cell semapv:crossSpeciesExactMatch FMA:263056 semapv:UnspecifiedMatching
+CL:1000322 pancreatic goblet cell semapv:crossSpeciesExactMatch FMA:263058 semapv:UnspecifiedMatching
+CL:1000323 pyloric gastric gland goblet cell semapv:crossSpeciesExactMatch FMA:263061 semapv:UnspecifiedMatching
+CL:1000324 duodenal goblet cell semapv:crossSpeciesExactMatch FMA:263063 semapv:UnspecifiedMatching
+CL:1000325 jejunal goblet cell semapv:crossSpeciesExactMatch FMA:263065 semapv:UnspecifiedMatching
+CL:1000326 ileal goblet cell semapv:crossSpeciesExactMatch FMA:263067 semapv:UnspecifiedMatching
+CL:1000327 appendix goblet cell semapv:crossSpeciesExactMatch FMA:263069 semapv:UnspecifiedMatching
+CL:1000329 tracheal goblet cell semapv:crossSpeciesExactMatch FMA:263075 semapv:UnspecifiedMatching
+CL:1000330 serous cell of epithelium of trachea semapv:crossSpeciesExactMatch FMA:263078 semapv:UnspecifiedMatching
+CL:1000331 serous cell of epithelium of bronchus semapv:crossSpeciesExactMatch FMA:263080 semapv:UnspecifiedMatching
+CL:1000332 serous cell of epithelium of terminal bronchiole semapv:crossSpeciesExactMatch FMA:263082 semapv:UnspecifiedMatching
+CL:1000333 serous cell of epithelium of lobular bronchiole semapv:crossSpeciesExactMatch FMA:263084 semapv:UnspecifiedMatching
+CL:1000334 enterocyte of epithelium of small intestine semapv:crossSpeciesExactMatch FMA:263086 semapv:UnspecifiedMatching
+CL:1000335 enterocyte of epithelium of intestinal villus semapv:crossSpeciesExactMatch FMA:263088 semapv:UnspecifiedMatching
+CL:1000337 enterocyte of epithelium of duodenal gland semapv:crossSpeciesExactMatch FMA:263092 semapv:UnspecifiedMatching
+CL:1000338 enterocyte of epithelium of crypt of Lieberkuhn of small intestine semapv:crossSpeciesExactMatch FMA:263094 semapv:UnspecifiedMatching
+CL:1000339 enterocyte of epithelium proper of small intestine semapv:crossSpeciesExactMatch FMA:263096 semapv:UnspecifiedMatching
+CL:1000340 enterocyte of epithelium proper of duodenum semapv:crossSpeciesExactMatch FMA:263098 semapv:UnspecifiedMatching
+CL:1000341 enterocyte of epithelium proper of jejunum semapv:crossSpeciesExactMatch FMA:263100 semapv:UnspecifiedMatching
+CL:1000342 enterocyte of epithelium proper of ileum semapv:crossSpeciesExactMatch FMA:263102 semapv:UnspecifiedMatching
+CL:1000343 paneth cell of epithelium of small intestine semapv:crossSpeciesExactMatch FMA:263104 semapv:UnspecifiedMatching
+CL:1000344 paneth cell of epithelium proper of small intestine semapv:crossSpeciesExactMatch FMA:263106 semapv:UnspecifiedMatching
+CL:1000345 paneth cell of epithelium of crypt of Lieberkuhn of small intestine semapv:crossSpeciesExactMatch FMA:263108 semapv:UnspecifiedMatching
+CL:1000346 enterocyte of epithelium proper of large intestine semapv:crossSpeciesExactMatch FMA:263090 semapv:UnspecifiedMatching
+CL:1000346 enterocyte of epithelium proper of large intestine semapv:crossSpeciesExactMatch FMA:263112 semapv:UnspecifiedMatching
+CL:1000347 colonocyte semapv:crossSpeciesExactMatch FMA:263114 semapv:UnspecifiedMatching
+CL:1000348 basal cell of epithelium of trachea semapv:crossSpeciesExactMatch FMA:263118 semapv:UnspecifiedMatching
+CL:1000349 basal cell of epithelium of bronchus semapv:crossSpeciesExactMatch FMA:263120 semapv:UnspecifiedMatching
+CL:1000350 basal cell of epithelium of terminal bronchiole semapv:crossSpeciesExactMatch FMA:263122 semapv:UnspecifiedMatching
+CL:1000351 basal cell of epithelium of respiratory bronchiole semapv:crossSpeciesExactMatch FMA:263124 semapv:UnspecifiedMatching
+CL:1000352 basal cell of epithelium of lobular bronchiole semapv:crossSpeciesExactMatch FMA:263126 semapv:UnspecifiedMatching
+CL:1000353 microfold cell of epithelium of small intestine semapv:crossSpeciesExactMatch FMA:263128 semapv:UnspecifiedMatching
+CL:1000354 microfold cell of epithelium of intestinal villus semapv:crossSpeciesExactMatch FMA:263130 semapv:UnspecifiedMatching
+CL:1000355 microfold cell of epithelium proper of small intestine semapv:crossSpeciesExactMatch FMA:263132 semapv:UnspecifiedMatching
+CL:1000356 microfold cell of epithelium proper of duodenum semapv:crossSpeciesExactMatch FMA:263134 semapv:UnspecifiedMatching
+CL:1000357 microfold cell of epithelium proper of jejunum semapv:crossSpeciesExactMatch FMA:263136 semapv:UnspecifiedMatching
+CL:1000358 microfold cell of epithelium proper of ileum semapv:crossSpeciesExactMatch FMA:263138 semapv:UnspecifiedMatching
+CL:1000359 microfold cell of epithelium proper of appendix semapv:crossSpeciesExactMatch FMA:263140 semapv:UnspecifiedMatching
+CL:1000360 microfold cell of epithelium proper of large intestine semapv:crossSpeciesExactMatch FMA:263142 semapv:UnspecifiedMatching
+CL:1000361 transitional myocyte of interatrial septum semapv:crossSpeciesExactMatch FMA:263152 semapv:UnspecifiedMatching
+CL:1000362 transitional myocyte of interventricular septum semapv:crossSpeciesExactMatch FMA:263154 semapv:UnspecifiedMatching
+CL:1000363 transitional myocyte of atrial branch of anterior internodal tract semapv:crossSpeciesExactMatch FMA:263156 semapv:UnspecifiedMatching
+CL:1000364 transitional myocyte of anterior internodal tract semapv:crossSpeciesExactMatch FMA:263158 semapv:UnspecifiedMatching
+CL:1000365 transitional myocyte of atrial septal branch of anterior internodal tract semapv:crossSpeciesExactMatch FMA:263160 semapv:UnspecifiedMatching
+CL:1000366 transitional myocyte of middle internodal tract semapv:crossSpeciesExactMatch FMA:263162 semapv:UnspecifiedMatching
+CL:1000367 transitional myocyte of posterior internodal tract semapv:crossSpeciesExactMatch FMA:263164 semapv:UnspecifiedMatching
+CL:1000368 transitional myocyte of anterior division of left branch of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263166 semapv:UnspecifiedMatching
+CL:1000369 transitional myocyte of septal division of left branch of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263168 semapv:UnspecifiedMatching
+CL:1000370 transitional myocyte of left branch of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263170 semapv:UnspecifiedMatching
+CL:1000371 transitional myocyte of right branch of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263172 semapv:UnspecifiedMatching
+CL:1000372 transitional myocyte of atrial part of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263174 semapv:UnspecifiedMatching
+CL:1000373 transitional myocyte of ventricular part of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263176 semapv:UnspecifiedMatching
+CL:1000374 transitional myocyte of posterior division of left branch of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263178 semapv:UnspecifiedMatching
+CL:1000375 myocardial endocrine cell of septal division of left branch of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:263180 semapv:UnspecifiedMatching
+CL:1000376 Purkinje myocyte of interventricular septum semapv:crossSpeciesExactMatch FMA:263182 semapv:UnspecifiedMatching
+CL:1000377 dense-core granulated cell of epithelium of trachea semapv:crossSpeciesExactMatch FMA:263184 semapv:UnspecifiedMatching
+CL:1000378 type 1 vestibular sensory cell of stato-acoustic epithelium semapv:crossSpeciesExactMatch FMA:263186 semapv:UnspecifiedMatching
+CL:1000379 type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth semapv:crossSpeciesExactMatch FMA:263188 semapv:UnspecifiedMatching
+CL:1000380 type 1 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth semapv:crossSpeciesExactMatch FMA:263190 semapv:UnspecifiedMatching
+CL:1000381 type 1 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth semapv:crossSpeciesExactMatch FMA:263192 semapv:UnspecifiedMatching
+CL:1000382 type 2 vestibular sensory cell of stato-acoustic epithelium semapv:crossSpeciesExactMatch FMA:263194 semapv:UnspecifiedMatching
+CL:1000383 type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth semapv:crossSpeciesExactMatch FMA:263196 semapv:UnspecifiedMatching
+CL:1000384 type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth semapv:crossSpeciesExactMatch FMA:263198 semapv:UnspecifiedMatching
+CL:1000385 type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth semapv:crossSpeciesExactMatch FMA:263200 semapv:UnspecifiedMatching
+CL:1000391 melanocyte of eyelid semapv:crossSpeciesExactMatch FMA:59175 semapv:UnspecifiedMatching
+CL:1000394 myoepithelial cell of intralobular lactiferous duct semapv:crossSpeciesExactMatch FMA:62158 semapv:UnspecifiedMatching
+CL:1000397 endothelial cell of venous sinus of red pulp of spleen semapv:crossSpeciesExactMatch FMA:62817 semapv:UnspecifiedMatching
+CL:1000398 endothelial cell of hepatic sinusoid semapv:crossSpeciesExactMatch FMA:62911 semapv:UnspecifiedMatching
+CL:1000405 epithelial cell of appendix semapv:crossSpeciesExactMatch FMA:63602 semapv:UnspecifiedMatching
+CL:1000409 myocyte of sinoatrial node semapv:crossSpeciesExactMatch FMA:67102 semapv:UnspecifiedMatching
+CL:1000410 myocyte of atrioventricular node semapv:crossSpeciesExactMatch FMA:67106 semapv:UnspecifiedMatching
+CL:1000411 endothelial cell of Peyer's patch semapv:crossSpeciesExactMatch FMA:67757 semapv:UnspecifiedMatching
+CL:1000412 endothelial cell of arteriole semapv:crossSpeciesExactMatch KUPO:0001097 semapv:UnspecifiedMatching
+CL:1000412 endothelial cell of arteriole semapv:crossSpeciesExactMatch FMA:67760 semapv:UnspecifiedMatching
+CL:1000413 endothelial cell of artery semapv:crossSpeciesExactMatch KUPO:0001095 semapv:UnspecifiedMatching
+CL:1000413 endothelial cell of artery semapv:crossSpeciesExactMatch FMA:67761 semapv:UnspecifiedMatching
+CL:1000414 endothelial cell of venule semapv:crossSpeciesExactMatch FMA:67762 semapv:UnspecifiedMatching
+CL:1000415 epithelial cell of gallbladder semapv:crossSpeciesExactMatch FMA:67780 semapv:UnspecifiedMatching
+CL:1000417 myoepithelial cell of sweat gland semapv:crossSpeciesExactMatch FMA:67801 semapv:UnspecifiedMatching
+CL:1000418 myoepithelial cell of lactiferous alveolus semapv:crossSpeciesExactMatch FMA:67802 semapv:UnspecifiedMatching
+CL:1000419 myoepithelial cell of lactiferous duct semapv:crossSpeciesExactMatch FMA:67803 semapv:UnspecifiedMatching
+CL:1000420 myoepithelial cell of terminal lactiferous duct semapv:crossSpeciesExactMatch FMA:67804 semapv:UnspecifiedMatching
+CL:1000424 chromaffin cell of paraaortic body semapv:crossSpeciesExactMatch FMA:69328 semapv:UnspecifiedMatching
+CL:1000425 chromaffin cell of paraganglion semapv:crossSpeciesExactMatch FMA:69335 semapv:UnspecifiedMatching
+CL:1000426 chromaffin cell of adrenal gland semapv:crossSpeciesExactMatch FMA:69794 semapv:UnspecifiedMatching
+CL:1000427 adrenal cortex chromaffin cell semapv:crossSpeciesExactMatch FMA:69795 semapv:UnspecifiedMatching
+CL:1000428 stem cell of epidermis semapv:crossSpeciesExactMatch ZFA:0007122 epidermal stem cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:1000428 stem cell of epidermis semapv:crossSpeciesExactMatch FMA:70541 semapv:UnspecifiedMatching
+CL:1000432 conjunctival epithelial cell semapv:crossSpeciesExactMatch FMA:70552 semapv:UnspecifiedMatching
+CL:1000433 epithelial cell of lacrimal canaliculus semapv:crossSpeciesExactMatch FMA:70553 semapv:UnspecifiedMatching
+CL:1000434 epithelial cell of external acoustic meatus semapv:crossSpeciesExactMatch FMA:70555 semapv:UnspecifiedMatching
+CL:1000435 epithelial cell of lacrimal drainage system semapv:crossSpeciesExactMatch FMA:70559 semapv:UnspecifiedMatching
+CL:1000436 epithelial cell of lacrimal sac semapv:crossSpeciesExactMatch FMA:70560 semapv:UnspecifiedMatching
+CL:1000437 epithelial cell of nasolacrimal duct semapv:crossSpeciesExactMatch FMA:70561 semapv:UnspecifiedMatching
+CL:1000438 epithelial cell of wall of inferior part of anal canal semapv:crossSpeciesExactMatch FMA:70562 semapv:UnspecifiedMatching
+CL:1000441 epithelial cell of viscerocranial mucosa semapv:crossSpeciesExactMatch FMA:70583 semapv:UnspecifiedMatching
+CL:1000442 urothelial cell of trigone of urinary bladder semapv:crossSpeciesExactMatch FMA:70598 semapv:UnspecifiedMatching
+CL:1000443 ciliary muscle cell semapv:crossSpeciesExactMatch FMA:70610 semapv:UnspecifiedMatching
+CL:1000444 mesothelial cell of anterior chamber of eye semapv:crossSpeciesExactMatch FMA:70615 semapv:UnspecifiedMatching
+CL:1000445 myoepithelial cell of dilator pupillae semapv:crossSpeciesExactMatch FMA:70619 semapv:UnspecifiedMatching
+CL:1000447 epithelial cell of stratum germinativum of esophagus semapv:crossSpeciesExactMatch FMA:70731 semapv:UnspecifiedMatching
+CL:1000448 epithelial cell of sweat gland semapv:crossSpeciesExactMatch FMA:70952 semapv:UnspecifiedMatching
+CL:1000449 epithelial cell of nephron semapv:crossSpeciesExactMatch FMA:70965 semapv:UnspecifiedMatching
+CL:1000450 epithelial cell of glomerular capsule semapv:crossSpeciesExactMatch KUPO:0001034 semapv:UnspecifiedMatching
+CL:1000450 epithelial cell of glomerular capsule semapv:crossSpeciesExactMatch FMA:70966 semapv:UnspecifiedMatching
+CL:1000452 parietal epithelial cell semapv:crossSpeciesExactMatch KUPO:0001035 semapv:UnspecifiedMatching
+CL:1000452 parietal epithelial cell semapv:crossSpeciesExactMatch FMA:70968 semapv:UnspecifiedMatching
+CL:1000453 epithelial cell of intermediate tubule semapv:crossSpeciesExactMatch FMA:70980 semapv:UnspecifiedMatching
+CL:1000454 kidney collecting duct epithelial cell semapv:crossSpeciesExactMatch KUPO:0001059 semapv:UnspecifiedMatching
+CL:1000454 kidney collecting duct epithelial cell semapv:crossSpeciesExactMatch FMA:70982 semapv:UnspecifiedMatching
+CL:1000456 mesothelial cell of parietal peritoneum semapv:crossSpeciesExactMatch FMA:72142 semapv:UnspecifiedMatching
+CL:1000457 mesothelial cell of visceral peritoneum semapv:crossSpeciesExactMatch FMA:72143 semapv:UnspecifiedMatching
+CL:1000458 melanocyte of skin semapv:crossSpeciesExactMatch FMA:72144 semapv:UnspecifiedMatching
+CL:1000465 chromaffin cell of ovary semapv:crossSpeciesExactMatch FMA:74319 semapv:UnspecifiedMatching
+CL:1000466 chromaffin cell of right ovary semapv:crossSpeciesExactMatch FMA:74320 semapv:UnspecifiedMatching
+CL:1000467 chromaffin cell of left ovary semapv:crossSpeciesExactMatch FMA:74321 semapv:UnspecifiedMatching
+CL:1000468 myoepithelial cell of acinus of lactiferous gland semapv:crossSpeciesExactMatch FMA:74469 semapv:UnspecifiedMatching
+CL:1000469 myoepithelial cell of main lactiferous duct semapv:crossSpeciesExactMatch FMA:74499 semapv:UnspecifiedMatching
+CL:1000470 myoepithelial cell of primary lactiferous duct semapv:crossSpeciesExactMatch FMA:74500 semapv:UnspecifiedMatching
+CL:1000471 myoepithelial cell of secondary lactiferous duct semapv:crossSpeciesExactMatch FMA:74501 semapv:UnspecifiedMatching
+CL:1000472 myoepithelial cell of tertiary lactiferous duct semapv:crossSpeciesExactMatch FMA:74502 semapv:UnspecifiedMatching
+CL:1000473 myoepithelial cell of quarternary lactiferous duct semapv:crossSpeciesExactMatch FMA:74503 semapv:UnspecifiedMatching
+CL:1000477 cardiac pacemaker cell of sinoatrial node semapv:crossSpeciesExactMatch FMA:83383 semapv:UnspecifiedMatching
+CL:1000478 transitional myocyte of sinoatrial node semapv:crossSpeciesExactMatch FMA:83384 semapv:UnspecifiedMatching
+CL:1000479 Purkinje myocyte of atrioventricular node semapv:crossSpeciesExactMatch FMA:83386 semapv:UnspecifiedMatching
+CL:1000480 transitional myocyte of internodal tract semapv:crossSpeciesExactMatch FMA:83387 semapv:UnspecifiedMatching
+CL:1000481 transitional myocyte of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:83388 semapv:UnspecifiedMatching
+CL:1000482 myocardial endocrine cell of interventricular septum semapv:crossSpeciesExactMatch FMA:83390 semapv:UnspecifiedMatching
+CL:1000483 Purkinje myocyte of internodal tract semapv:crossSpeciesExactMatch FMA:83392 semapv:UnspecifiedMatching
+CL:1000484 Purkinje myocyte of atrioventricular bundle semapv:crossSpeciesExactMatch FMA:83393 semapv:UnspecifiedMatching
+CL:1000486 basal cell of urothelium semapv:crossSpeciesExactMatch FMA:84150 semapv:UnspecifiedMatching
+CL:1000487 smooth muscle cell of prostate semapv:crossSpeciesExactMatch FMA:84583 semapv:UnspecifiedMatching
+CL:1000488 cholangiocyte semapv:crossSpeciesExactMatch ZFA:0009397 cholangiocyte semapv:UnspecifiedMatching obo:zfa.owl
+CL:1000488 cholangiocyte semapv:crossSpeciesExactMatch FMA:86481 semapv:UnspecifiedMatching
+CL:1000489 reticular cell of splenic cord semapv:crossSpeciesExactMatch FMA:86497 semapv:UnspecifiedMatching
+CL:1000490 mesothelial cell of peritoneum semapv:crossSpeciesExactMatch FMA:86736 semapv:UnspecifiedMatching
+CL:1000491 mesothelial cell of pleura semapv:crossSpeciesExactMatch FMA:86737 semapv:UnspecifiedMatching
+CL:1000492 mesothelial cell of parietal pleura semapv:crossSpeciesExactMatch FMA:86738 semapv:UnspecifiedMatching
+CL:1000493 mesothelial cell of visceral pleura semapv:crossSpeciesExactMatch FMA:86739 semapv:UnspecifiedMatching
+CL:1000494 nephron tubule epithelial cell semapv:crossSpeciesExactMatch KUPO:0001022 semapv:UnspecifiedMatching
+CL:1000494 nephron tubule epithelial cell semapv:crossSpeciesExactMatch FMA:86785 semapv:UnspecifiedMatching
+CL:1000495 small intestine goblet cell semapv:crossSpeciesExactMatch FMA:86929 semapv:UnspecifiedMatching
+CL:1000497 kidney cell semapv:crossSpeciesExactMatch KUPO:0001010 semapv:UnspecifiedMatching
+CL:1000497 kidney cell semapv:crossSpeciesExactMatch ZFA:0009389 kidney cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:1000500 kidney interstitial cell semapv:crossSpeciesExactMatch KUPO:0001013 semapv:UnspecifiedMatching
+CL:1000500 kidney interstitial cell semapv:crossSpeciesExactMatch ZFA:0009390 kidney interstitial cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:1000504 kidney medulla cell semapv:crossSpeciesExactMatch KUPO:0001017 semapv:UnspecifiedMatching
+CL:1000504 kidney medulla cell semapv:crossSpeciesExactMatch ZFA:0009391 kidney medulla cell semapv:UnspecifiedMatching obo:zfa.owl
+CL:1000505 kidney pelvis cell semapv:crossSpeciesExactMatch KUPO:0001018 semapv:UnspecifiedMatching
+CL:1000507 kidney tubule cell semapv:crossSpeciesExactMatch KUPO:0001020 semapv:UnspecifiedMatching
+CL:1000510 kidney glomerular epithelial cell semapv:crossSpeciesExactMatch KUPO:0001023 semapv:UnspecifiedMatching
+CL:1000546 kidney medulla collecting duct epithelial cell semapv:crossSpeciesExactMatch KUPO:0001060 semapv:UnspecifiedMatching
+CL:1000547 kidney inner medulla collecting duct epithelial cell semapv:crossSpeciesExactMatch KUPO:0001061 semapv:UnspecifiedMatching
+CL:1000548 kidney outer medulla collecting duct epithelial cell semapv:crossSpeciesExactMatch KUPO:0001062 semapv:UnspecifiedMatching
+CL:1000549 kidney cortex collecting duct epithelial cell semapv:crossSpeciesExactMatch KUPO:0001063 semapv:UnspecifiedMatching
+CL:1000550 kidney papillary duct principal epithelial cell semapv:crossSpeciesExactMatch KUPO:0001064 semapv:UnspecifiedMatching
+CL:1000596 inner renal cortex cell semapv:crossSpeciesExactMatch KUPO:0001111 semapv:UnspecifiedMatching
+CL:1000597 papillary tips cell semapv:crossSpeciesExactMatch KUPO:0001112 semapv:UnspecifiedMatching
+CL:1000600 lower urinary tract cell semapv:crossSpeciesExactMatch KUPO:0001115 semapv:UnspecifiedMatching
+CL:1000601 ureteral cell semapv:crossSpeciesExactMatch KUPO:0001116 semapv:UnspecifiedMatching
+CL:1000606 kidney nerve cell semapv:crossSpeciesExactMatch KUPO:0001015 semapv:UnspecifiedMatching
+CL:1000612 kidney corpuscule cell semapv:crossSpeciesExactMatch KUPO:0001021 semapv:UnspecifiedMatching
+CL:1000615 kidney cortex tubule cell semapv:crossSpeciesExactMatch KUPO:0001024 semapv:UnspecifiedMatching
+CL:1000616 kidney outer medulla cell semapv:crossSpeciesExactMatch KUPO:0001025 semapv:UnspecifiedMatching
+CL:1000617 kidney inner medulla cell semapv:crossSpeciesExactMatch KUPO:0001026 semapv:UnspecifiedMatching
+CL:1000618 juxtaglomerular complex cell semapv:crossSpeciesExactMatch KUPO:0001028 semapv:UnspecifiedMatching
+CL:1000681 kidney cortex interstitial cell semapv:crossSpeciesExactMatch KUPO:0001091 semapv:UnspecifiedMatching
+CL:1000682 kidney medulla interstitial cell semapv:crossSpeciesExactMatch KUPO:0001092 semapv:UnspecifiedMatching
+CL:1000691 kidney interstitial myofibroblast semapv:crossSpeciesExactMatch KUPO:0001101 semapv:UnspecifiedMatching
+CL:1000692 kidney interstitial fibroblast semapv:crossSpeciesExactMatch KUPO:0001102 semapv:UnspecifiedMatching
+CL:1000693 kidney interstitial fibrocyte semapv:crossSpeciesExactMatch KUPO:0001103 semapv:UnspecifiedMatching
+CL:1000695 kidney interstitial alternatively activated macrophage semapv:crossSpeciesExactMatch KUPO:0001106 semapv:UnspecifiedMatching
+CL:1000696 kidney interstitial inflammatory macrophage semapv:crossSpeciesExactMatch KUPO:0001107 semapv:UnspecifiedMatching
+CL:1000697 kidney interstitial suppressor macrophage semapv:crossSpeciesExactMatch KUPO:0001108 semapv:UnspecifiedMatching
+CL:1000698 kidney resident macrophage semapv:crossSpeciesExactMatch KUPO:0001109 semapv:UnspecifiedMatching
+CL:1000699 kidney resident dendritic cell semapv:crossSpeciesExactMatch KUPO:0001110 semapv:UnspecifiedMatching
+CL:1000702 kidney pelvis smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001113 semapv:UnspecifiedMatching
+CL:1000703 kidney pelvis urothelial cell semapv:crossSpeciesExactMatch KUPO:0001114 semapv:UnspecifiedMatching
+CL:1000706 ureter urothelial cell semapv:crossSpeciesExactMatch KUPO:0001117 semapv:UnspecifiedMatching
+CL:1000708 ureter adventitial cell semapv:crossSpeciesExactMatch KUPO:0001119 semapv:UnspecifiedMatching
+CL:1000714 kidney cortex collecting duct principal cell semapv:crossSpeciesExactMatch KUPO:0001130 semapv:UnspecifiedMatching
+CL:1000715 kidney cortex collecting duct intercalated cell semapv:crossSpeciesExactMatch KUPO:0001131 semapv:UnspecifiedMatching
+CL:1000716 kidney outer medulla collecting duct principal cell semapv:crossSpeciesExactMatch KUPO:0001132 semapv:UnspecifiedMatching
+CL:1000717 kidney outer medulla collecting duct intercalated cell semapv:crossSpeciesExactMatch KUPO:0001133 semapv:UnspecifiedMatching
+CL:1000718 kidney inner medulla collecting duct principal cell semapv:crossSpeciesExactMatch KUPO:0001134 semapv:UnspecifiedMatching
+CL:1000719 kidney inner medulla collecting duct intercalated cell semapv:crossSpeciesExactMatch KUPO:0001135 semapv:UnspecifiedMatching
+CL:1000720 kidney papillary duct intercalated cell semapv:crossSpeciesExactMatch KUPO:0001136 semapv:UnspecifiedMatching
+CL:1000721 kidney papillary duct principal cell semapv:crossSpeciesExactMatch KUPO:0001137 semapv:UnspecifiedMatching
+CL:1000742 glomerular mesangial cell semapv:crossSpeciesExactMatch KUPO:0001032 semapv:UnspecifiedMatching
+CL:1000746 glomerular cell semapv:crossSpeciesExactMatch KUPO:0001036 semapv:UnspecifiedMatching
+CL:1000768 kidney connecting tubule epithelial cell semapv:crossSpeciesExactMatch KUPO:0001058 semapv:UnspecifiedMatching
+CL:1000803 kidney inner medulla interstitial cell semapv:crossSpeciesExactMatch KUPO:0001093 semapv:UnspecifiedMatching
+CL:1000804 kidney outer medulla interstitial cell semapv:crossSpeciesExactMatch KUPO:0001094 semapv:UnspecifiedMatching
+CL:1000838 kidney proximal convoluted tubule epithelial cell semapv:crossSpeciesExactMatch KUPO:0001045 semapv:UnspecifiedMatching
+CL:1000839 kidney proximal straight tubule epithelial cell semapv:crossSpeciesExactMatch KUPO:0001046 semapv:UnspecifiedMatching
+CL:1000849 kidney distal convoluted tubule epithelial cell semapv:crossSpeciesExactMatch KUPO:0001056 semapv:UnspecifiedMatching
+CL:1000850 macula densa epithelial cell semapv:crossSpeciesExactMatch KUPO:0001057 semapv:UnspecifiedMatching
+CL:1000854 kidney blood vessel cell semapv:crossSpeciesExactMatch KUPO:0001014 semapv:UnspecifiedMatching
+CL:1000891 kidney arterial blood vessel cell semapv:crossSpeciesExactMatch KUPO:0001029 semapv:UnspecifiedMatching
+CL:1000892 kidney capillary endothelial cell semapv:crossSpeciesExactMatch KUPO:0001030 semapv:UnspecifiedMatching
+CL:1000893 kidney venous blood vessel cell semapv:crossSpeciesExactMatch KUPO:0001031 semapv:UnspecifiedMatching
+CL:1000909 kidney loop of Henle epithelial cell semapv:crossSpeciesExactMatch KUPO:0001047 semapv:UnspecifiedMatching
+CL:1000979 ureter smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001118 semapv:UnspecifiedMatching
+CL:1001005 glomerular capillary endothelial cell semapv:crossSpeciesExactMatch KUPO:0001037 semapv:UnspecifiedMatching
+CL:1001006 kidney afferent arteriole cell semapv:crossSpeciesExactMatch KUPO:0001038 semapv:UnspecifiedMatching
+CL:1001009 kidney efferent arteriole cell semapv:crossSpeciesExactMatch KUPO:0001041 semapv:UnspecifiedMatching
+CL:1001016 kidney loop of Henle ascending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001048 semapv:UnspecifiedMatching
+CL:1001021 kidney loop of Henle descending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001053 semapv:UnspecifiedMatching
+CL:1001033 peritubular capillary endothelial cell semapv:crossSpeciesExactMatch KUPO:0001065 semapv:UnspecifiedMatching
+CL:1001036 vasa recta cell semapv:crossSpeciesExactMatch KUPO:0001068 semapv:UnspecifiedMatching
+CL:1001045 kidney cortex artery cell semapv:crossSpeciesExactMatch KUPO:0001077 semapv:UnspecifiedMatching
+CL:1001052 kidney cortex vein cell semapv:crossSpeciesExactMatch KUPO:0001084 semapv:UnspecifiedMatching
+CL:1001064 kidney artery smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001096 semapv:UnspecifiedMatching
+CL:1001066 kidney arteriole smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001098 semapv:UnspecifiedMatching
+CL:1001068 kidney venous system smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001100 semapv:UnspecifiedMatching
+CL:1001096 kidney afferent arteriole endothelial cell semapv:crossSpeciesExactMatch KUPO:0001039 semapv:UnspecifiedMatching
+CL:1001097 kidney afferent arteriole smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001040 semapv:UnspecifiedMatching
+CL:1001099 kidney efferent arteriole endothelial cell semapv:crossSpeciesExactMatch KUPO:0001042 semapv:UnspecifiedMatching
+CL:1001100 kidney efferent arteriole smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001043 semapv:UnspecifiedMatching
+CL:1001106 kidney loop of Henle thick ascending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001049 semapv:UnspecifiedMatching
+CL:1001107 kidney loop of Henle thin ascending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001050 semapv:UnspecifiedMatching
+CL:1001108 kidney loop of Henle medullary thick ascending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001051 semapv:UnspecifiedMatching
+CL:1001109 kidney loop of Henle cortical thick ascending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001052 semapv:UnspecifiedMatching
+CL:1001111 kidney loop of Henle thin descending limb epithelial cell semapv:crossSpeciesExactMatch KUPO:0001054 semapv:UnspecifiedMatching
+CL:1001123 kidney outer medulla peritubular capillary cell semapv:crossSpeciesExactMatch KUPO:0001066 semapv:UnspecifiedMatching
+CL:1001124 kidney cortex peritubular capillary cell semapv:crossSpeciesExactMatch KUPO:0001067 semapv:UnspecifiedMatching
+CL:1001126 inner renal medulla vasa recta cell semapv:crossSpeciesExactMatch KUPO:0001069 semapv:UnspecifiedMatching
+CL:1001127 outer renal medulla vasa recta cell semapv:crossSpeciesExactMatch KUPO:0001070 semapv:UnspecifiedMatching
+CL:1001131 vasa recta ascending limb cell semapv:crossSpeciesExactMatch KUPO:0001074 semapv:UnspecifiedMatching
+CL:1001135 arcuate artery cell semapv:crossSpeciesExactMatch KUPO:0001078 semapv:UnspecifiedMatching
+CL:1001138 interlobular artery cell semapv:crossSpeciesExactMatch KUPO:0001081 semapv:UnspecifiedMatching
+CL:1001142 arcuate vein cell semapv:crossSpeciesExactMatch KUPO:0001085 semapv:UnspecifiedMatching
+CL:1001145 interlobular vein cell semapv:crossSpeciesExactMatch KUPO:0001088 semapv:UnspecifiedMatching
+CL:1001209 inner medulla vasa recta ascending limb cell semapv:crossSpeciesExactMatch KUPO:0001075 semapv:UnspecifiedMatching
+CL:1001210 outer medulla vasa recta ascending limb cell semapv:crossSpeciesExactMatch KUPO:0001076 semapv:UnspecifiedMatching
+CL:1001213 arcuate artery endothelial cell semapv:crossSpeciesExactMatch KUPO:0001079 semapv:UnspecifiedMatching
+CL:1001214 arcuate artery smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001080 semapv:UnspecifiedMatching
+CL:1001216 interlobulary artery endothelial cell semapv:crossSpeciesExactMatch KUPO:0001082 semapv:UnspecifiedMatching
+CL:1001217 interlobulary artery smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001083 semapv:UnspecifiedMatching
+CL:1001220 arcuate vein endothelial cell semapv:crossSpeciesExactMatch KUPO:0001086 semapv:UnspecifiedMatching
+CL:1001221 arcuate vein smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001087 semapv:UnspecifiedMatching
+CL:1001223 interlobulary vein endothelial cell semapv:crossSpeciesExactMatch KUPO:0001089 semapv:UnspecifiedMatching
+CL:1001224 interlobulary vein smooth muscle cell semapv:crossSpeciesExactMatch KUPO:0001090 semapv:UnspecifiedMatching
+CL:1001225 kidney collecting duct cell semapv:crossSpeciesExactMatch KUPO:0001012 semapv:UnspecifiedMatching
+CL:1001285 vasa recta descending limb cell semapv:crossSpeciesExactMatch KUPO:0001071 semapv:UnspecifiedMatching
+CL:1001286 inner medulla vasa recta descending limb cell semapv:crossSpeciesExactMatch KUPO:0001072 semapv:UnspecifiedMatching
+CL:1001287 outer medulla vasa recta descending limb cell semapv:crossSpeciesExactMatch KUPO:0001073 semapv:UnspecifiedMatching
+CL:1001318 renal interstitial pericyte semapv:crossSpeciesExactMatch KUPO:0001104 semapv:UnspecifiedMatching
+CL:1001319 bladder cell semapv:crossSpeciesExactMatch KUPO:0001120 semapv:UnspecifiedMatching
+CL:1001320 urethra cell semapv:crossSpeciesExactMatch KUPO:0001123 semapv:UnspecifiedMatching
+CL:1001428 bladder urothelial cell skos:narrowMatch NCIT:C32210 semapv:UnspecifiedMatching
+CL:1001428 bladder urothelial cell semapv:crossSpeciesExactMatch KUPO:0001121 semapv:UnspecifiedMatching
+CL:1001430 urethra urothelial cell semapv:crossSpeciesExactMatch KUPO:0001124 semapv:UnspecifiedMatching
+CL:1001431 kidney collecting duct principal cell semapv:crossSpeciesExactMatch KUPO:0001128 semapv:UnspecifiedMatching
+CL:1001432 kidney collecting duct intercalated cell semapv:crossSpeciesExactMatch KUPO:0001129 semapv:UnspecifiedMatching
+CL:1001433 epithelial cell of exocrine pancreas semapv:crossSpeciesExactMatch FMA:70986 semapv:UnspecifiedMatching
+CL:1001509 glycinergic neuron semapv:crossSpeciesExactMatch FBbt:00048032 glycinergic neuron semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:1001509 glycinergic neuron semapv:crossSpeciesExactMatch ZFA:0009396 glycinergic neuron semapv:UnspecifiedMatching obo:zfa.owl
+CL:1001569 hippocampal interneuron semapv:crossSpeciesExactMatch FMA:84777 semapv:UnspecifiedMatching
+CL:1001598 small intestine secretory cell semapv:crossSpeciesExactMatch FMA:86928 semapv:UnspecifiedMatching
+CL:1001611 cerebellar neuron semapv:crossSpeciesExactMatch FMA:84665 semapv:UnspecifiedMatching
+CL:2000002 decidual cell skos:narrowMatch NCIT:C32429 semapv:UnspecifiedMatching
+CL:2000019 compound eye photoreceptor cell semapv:crossSpeciesExactMatch FBbt:00006009 eye photoreceptor cell semapv:ManualMappingCuration obo:fbbt.owl 2024-07-12
+CL:2000032 peripheral nervous system neuron semapv:crossSpeciesExactMatch FMA:84664 semapv:UnspecifiedMatching
+CL:2000048 anterior horn motor neuron skos:narrowMatch NCIT:C12645 semapv:UnspecifiedMatching
+CL:4023120 cochlea auditory hair cell semapv:crossSpeciesExactMatch FMA:62364 semapv:UnspecifiedMatching
+CL:4030055 intermediate cell of urothelium semapv:crossSpeciesExactMatch FMA:84155 semapv:UnspecifiedMatching
+CL:4030056 umbrella cell of urothelium semapv:crossSpeciesExactMatch FMA:84149 semapv:UnspecifiedMatching
+CL:4042041 middle primary motoneuron semapv:crossSpeciesExactMatch ZFA:0005179 semapv:UnspecifiedMatching
diff --git a/src/mappings/fbbt.sssom.tsv b/src/mappings/fbbt.sssom.tsv
index 67f075b15..32f505ef2 100644
--- a/src/mappings/fbbt.sssom.tsv
+++ b/src/mappings/fbbt.sssom.tsv
@@ -1,17 +1,17 @@
#curie_map:
-# FBbt: "http://purl.obolibrary.org/obo/FBbt_"
-# ORCID: "https://orcid.org/"
-# UBERON: "http://purl.obolibrary.org/obo/UBERON_"
-# obo: "http://purl.obolibrary.org/obo/"
-#mapping_set_id: "http://purl.obolibrary.org/obo/fbbt/fbbt-mappings.sssom.tsv"
-#mapping_set_description: "Mappings between the Drosophila Anatomy Ontology and foreign ontologies."
+# FBbt: http://purl.obolibrary.org/obo/FBbt_
+# ORCID: https://orcid.org/
+# UBERON: http://purl.obolibrary.org/obo/UBERON_
+# obo: http://purl.obolibrary.org/obo/
+#mapping_set_id: http://purl.obolibrary.org/obo/fbbt/fbbt-mappings.sssom.tsv
+#mapping_set_description: Mappings between the Drosophila Anatomy Ontology and foreign ontologies.
#creator_id:
-# - "ORCID:0000-0002-1373-1705"
-# - "ORCID:0000-0002-6095-8718"
-#license: "https://creativecommons.org/licenses/by/4.0/"
-#subject_source: "obo:fbbt.owl"
-#object_source: "obo:uberon/core.owl"
-#mapping_date: "2024-07-12"
+# - ORCID:0000-0002-1373-1705
+# - ORCID:0000-0002-6095-8718
+#license: https://creativecommons.org/licenses/by/4.0/
+#subject_source: obo:fbbt.owl
+#object_source: obo:uberon.owl
+#mapping_date: 2024-07-12
subject_id subject_label predicate_id object_id object_label mapping_justification comment
FBbt:00000001 organism semapv:crossSpeciesExactMatch UBERON:0000468 multicellular organism semapv:ManualMappingCuration
FBbt:00000002 tagma semapv:crossSpeciesExactMatch UBERON:6000002 arthropod tagma semapv:ManualMappingCuration
diff --git a/src/ontology/components/hra_subset.owl b/src/ontology/components/hra_subset.owl
index 9a9bc198d..aac7fe90c 100644
--- a/src/ontology/components/hra_subset.owl
+++ b/src/ontology/components/hra_subset.owl
@@ -4987,15 +4987,6 @@
-
-
-
-
-
-
-
-
-
@@ -9847,6 +9838,15 @@
+
+
+
+
+
+
+
+
+
@@ -10531,6 +10531,15 @@
+
+
+
+
+
+
+
+
+
@@ -11719,15 +11728,6 @@
-
-
-
-
-
-
-
-
-
diff --git a/src/ontology/components/mappings.owl b/src/ontology/components/mappings.owl
index 15c4ef7d6..0e6b54176 100644
--- a/src/ontology/components/mappings.owl
+++ b/src/ontology/components/mappings.owl
@@ -158,6 +158,329 @@
FBbt:00007001
+
+ HsapDv:0010000
+ MmusDv:0000092
+ obo:BtauDv_0000078
+ obo:CfamDv_0000007
+ obo:DpseDv_0000005
+ obo:DsimDv_0000005
+ obo:EcabDv_0000007
+ obo:FcatDv_0000007
+ obo:GgalDv_0000076
+ obo:GgorDv_0000032
+ obo:MmulDv_0000052
+ obo:OanaDv_0000007
+ obo:OariDv_0000024
+ obo:PpanDv_0000041
+ obo:PtroDv_0000052
+ obo:RnorDv_0000061
+ obo:SsalDv_0000040
+ obo:SscrDv_0000084
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+ HsapDv:0010000
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+ MmusDv:0000092
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+ obo:CfamDv_0000007
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+ obo:DpseDv_0000005
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+ obo:EcabDv_0000007
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+ obo:FcatDv_0000007
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+ obo:GgalDv_0000076
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+ obo:GgorDv_0000032
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+ obo:MmulDv_0000052
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+ obo:OanaDv_0000007
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+ obo:PpanDv_0000041
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+ obo:SscrDv_0000084
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+ HsapDv:0000045
+ MmusDv:0000042
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+ obo:BtauDv_0000002
+ obo:CfamDv_0000002
+ obo:CporDv_0000002
+ obo:DpseDv_0000002
+ obo:DsimDv_0000002
+ obo:EcabDv_0000002
+ obo:FcatDv_0000002
+ obo:GgalDv_0000002
+ obo:GgorDv_0000002
+ obo:MdomDv_0000002
+ obo:MmulDv_0000002
+ obo:OanaDv_0000002
+ obo:OariDv_0000002
+ obo:OcunDv_0000002
+ obo:PpanDv_0000002
+ obo:PtroDv_0000002
+ obo:RnorDv_0000002
+ obo:SsalDv_0000002
+ obo:SscrDv_0000002
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+
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+ HsapDv:0000045
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+ MmusDv:0000042
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+ obo:AcarDv_0000002
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+ obo:BtauDv_0000002
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+ obo:CfamDv_0000002
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+ obo:EcabDv_0000002
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+ obo:FcatDv_0000002
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+ obo:GgalDv_0000002
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+ obo:GgorDv_0000002
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+ obo:MdomDv_0000002
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+ obo:MmulDv_0000002
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+ obo:OanaDv_0000002
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+ obo:OariDv_0000002
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+ obo:OcunDv_0000002
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+ obo:PpanDv_0000002
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+ obo:PtroDv_0000002
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+ obo:RnorDv_0000002
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+ obo:SsalDv_0000002
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+ obo:SscrDv_0000002
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+ obo:DpseDv_0000003
+ obo:DsimDv_0000003
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+ obo:DsimDv_0000004
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BTO:0006242
@@ -173,21 +496,916 @@
FBbt:00004927
-
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+
+ FBbt:00004927
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+
+ obo:SsalDv_0000038
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+ obo:SsalDv_0000038
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+ obo:EcabDv_0000001
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+ obo:GgalDv_0000001
+ obo:GgorDv_0000001
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+ obo:MmulDv_0000001
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+ obo:OcunDv_0000001
+ obo:PpanDv_0000001
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+ HsapDv:0000000
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+ obo:BtauDv_0000000
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+ obo:CporDv_0000000
+ obo:DpseDv_0000000
+ obo:DsimDv_0000000
+ obo:EcabDv_0000000
+ obo:FcatDv_0000000
+ obo:GgalDv_0000000
+ obo:GgorDv_0000000
+ obo:MdomDv_0000000
+ obo:MmulDv_0000000
+ obo:OanaDv_0000000
+ obo:OariDv_0000000
+ obo:OcunDv_0000000
+ obo:PpanDv_0000000
+ obo:PtroDv_0000000
+ obo:RnorDv_0000000
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+
+
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+ HsapDv:0000003
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+
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+ IDOMAL:0000302
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+
+ https://github.com/biopragmatics/biomappings
+
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+ obo:MdomDv_0000006
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+ HsapDv:0000258
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+ MmusDv:0000110
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- FBbt:00004927
-
+ obo:SsalDv_0000042
+
-
- IDOMAL:0000302
-
-
+
- IDOMAL:0000302
-
-
- https://github.com/biopragmatics/biomappings
+ obo:SscrDv_0000006
+
MESH:D001812
@@ -3020,6 +4238,242 @@
https://github.com/biopragmatics/biomappings
+
+ HsapDv:0000037
+ MmusDv:0000031
+ obo:RnorDv_0000011
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+ HsapDv:0000262
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+ obo:MdomDv_0000004
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+ obo:CfamDv_0000006
+ obo:CporDv_0000006
+ obo:EcabDv_0000006
+ obo:FcatDv_0000006
+ obo:GgalDv_0000080
+ obo:GgorDv_0000008
+ obo:MdomDv_0000025
+ obo:MmulDv_0000045
+ obo:OanaDv_0000006
+ obo:OariDv_0000008
+ obo:OcunDv_0000006
+ obo:PpanDv_0000040
+ obo:PtroDv_0000039
+ obo:RnorDv_0000060
+ obo:SscrDv_0000008
+
+
+
+
+ HsapDv:0000227
+
+
+
+
+
+ MmusDv:0000134
+
+
+
+
+
+ obo:AcarDv_0000006
+
+
+
+
+
+ obo:BtauDv_0000006
+
+
+
+
+
+ obo:CfamDv_0000006
+
+
+
+
+
+ obo:CporDv_0000006
+
+
+
+
+
+ obo:EcabDv_0000006
+
+
+
+
+
+ obo:FcatDv_0000006
+
+
+
+
+
+ obo:GgalDv_0000080
+
+
+
+
+
+ obo:GgorDv_0000008
+
+
+
+
+
+ obo:MdomDv_0000025
+
+
+
+
+
+ obo:MmulDv_0000045
+
+
+
+
+
+ obo:OanaDv_0000006
+
+
+
+
+
+ obo:OariDv_0000008
+
+
+
+
+
+ obo:OcunDv_0000006
+
+
+
+
+
+ obo:PpanDv_0000040
+
+
+
+
+
+ obo:PtroDv_0000039
+
+
+
+
+
+ obo:RnorDv_0000060
+
+
+
+
+
+ obo:SscrDv_0000008
+
+
+
+ obo:SsalDv_0000005
+
+
+
+
+ obo:SsalDv_0000005
+
+
+
+ obo:SsalDv_0000006
+
+
+
+
+ obo:SsalDv_0000006
+
+
+
+ obo:SsalDv_0000007
+
+
+
+
+ obo:SsalDv_0000007
+
+
MESH:D011301
@@ -3695,6 +5149,141 @@
https://github.com/biopragmatics/biomappings
+
+ HsapDv:0000226
+ MmusDv:0000136
+ obo:AcarDv_0000005
+ obo:BtauDv_0000005
+ obo:CfamDv_0000005
+ obo:CporDv_0000005
+ obo:EcabDv_0000005
+ obo:FcatDv_0000005
+ obo:GgalDv_0000077
+ obo:GgorDv_0000007
+ obo:MdomDv_0000007
+ obo:MmulDv_0000022
+ obo:OanaDv_0000005
+ obo:OariDv_0000007
+ obo:OcunDv_0000005
+ obo:PpanDv_0000017
+ obo:PtroDv_0000012
+ obo:RnorDv_0000059
+ obo:SscrDv_0000007
+
+
+
+
+ HsapDv:0000226
+
+
+
+
+
+ MmusDv:0000136
+
+
+
+
+
+ obo:AcarDv_0000005
+
+
+
+
+
+ obo:BtauDv_0000005
+
+
+
+
+
+ obo:CfamDv_0000005
+
+
+
+
+
+ obo:CporDv_0000005
+
+
+
+
+
+ obo:EcabDv_0000005
+
+
+
+
+
+ obo:FcatDv_0000005
+
+
+
+
+
+ obo:GgalDv_0000077
+
+
+
+
+
+ obo:GgorDv_0000007
+
+
+
+
+
+ obo:MdomDv_0000007
+
+
+
+
+
+ obo:MmulDv_0000022
+
+
+
+
+
+ obo:OanaDv_0000005
+
+
+
+
+
+ obo:OariDv_0000007
+
+
+
+
+
+ obo:OcunDv_0000005
+
+
+
+
+
+ obo:PpanDv_0000017
+
+
+
+
+
+ obo:PtroDv_0000012
+
+
+
+
+
+ obo:RnorDv_0000059
+
+
+
+
+
+ obo:SscrDv_0000007
+
+
FBbt:00005338
@@ -3724,6 +5313,201 @@
FBbt:00004987
+
+ HsapDv:0000260
+ MmusDv:0000138
+ obo:GgorDv_0000004
+ obo:MdomDv_0000032
+ obo:MmulDv_0000004
+ obo:OariDv_0000004
+ obo:PpanDv_0000004
+ obo:PtroDv_0000004
+ obo:RnorDv_0000056
+ obo:SscrDv_0000004
+
+
+
+
+ HsapDv:0000260
+
+
+
+
+
+ MmusDv:0000138
+
+
+
+
+
+ obo:GgorDv_0000004
+
+
+
+
+
+ obo:MdomDv_0000032
+
+
+
+
+
+ obo:MmulDv_0000004
+
+
+
+
+
+ obo:OariDv_0000004
+
+
+
+
+
+ obo:PpanDv_0000004
+
+
+
+
+
+ obo:PtroDv_0000004
+
+
+
+
+
+ obo:RnorDv_0000056
+
+
+
+
+
+ obo:SscrDv_0000004
+
+
+
+ HsapDv:0000271
+ MmusDv:0000178
+ obo:GgalDv_0000005
+ obo:GgorDv_0000005
+ obo:MdomDv_0000005
+ obo:MmulDv_0000014
+ obo:OariDv_0000005
+ obo:PpanDv_0000005
+ obo:PtroDv_0000005
+ obo:RnorDv_0000058
+ obo:SscrDv_0000005
+
+
+
+
+ HsapDv:0000271
+
+
+
+
+
+ MmusDv:0000178
+
+
+
+
+
+ obo:GgalDv_0000005
+
+
+
+
+
+ obo:GgorDv_0000005
+
+
+
+
+
+ obo:MdomDv_0000005
+
+
+
+
+
+ obo:MmulDv_0000014
+
+
+
+
+
+ obo:OariDv_0000005
+
+
+
+
+
+ obo:PpanDv_0000005
+
+
+
+
+
+ obo:PtroDv_0000005
+
+
+
+
+
+ obo:RnorDv_0000058
+
+
+
+
+
+ obo:SscrDv_0000005
+
+
+
+ HsapDv:0000261
+ MmusDv:0000177
+ obo:MdomDv_0000033
+ obo:MmulDv_0000053
+ obo:RnorDv_0000057
+ obo:SscrDv_0000085
+
+
+
+
+ HsapDv:0000261
+
+
+
+
+
+ MmusDv:0000177
+
+
+
+
+
+ obo:MdomDv_0000033
+
+
+
+
+
+ obo:MmulDv_0000053
+
+
+
+
+
+ obo:RnorDv_0000057
+
+
+
+
+
+ obo:SscrDv_0000085
+
+
FBbt:00007276
diff --git a/src/ontology/imports/local-cl.owl b/src/ontology/imports/local-cl.owl
index 87f71d139..48429879c 100644
--- a/src/ontology/imports/local-cl.owl
+++ b/src/ontology/imports/local-cl.owl
@@ -22,7 +22,7 @@ Prefix(ncbitaxon:=)
Ontology(
-
+
Annotation(obo:IAO_0000700 obo:CL_0000000)
Annotation(dc:description "An ontology of cell types.")
Annotation(dc:title "Cell Ontology")
@@ -38,9 +38,50 @@ Annotation(terms:contributor )
Annotation(terms:contributor )
Annotation(terms:license )
Annotation(rdfs:comment "See PMID:15693950, PMID:12799354, PMID:20123131, PMID:21208450; Contact Alexander Diehl, addiehl@buffalo.edu, university at buffalo.")
-Annotation(owl:versionInfo "2024-09-26")
+Annotation(owl:versionInfo "2025-01-08")
Declaration(Class(obo:BFO_0000002))
+Declaration(Class(obo:CLM_1000001))
+Declaration(Class(obo:CLM_1000002))
+Declaration(Class(obo:CLM_1000003))
+Declaration(Class(obo:CLM_1000004))
+Declaration(Class(obo:CLM_1000005))
+Declaration(Class(obo:CLM_1000006))
+Declaration(Class(obo:CLM_1000008))
+Declaration(Class(obo:CLM_1000009))
+Declaration(Class(obo:CLM_1000010))
+Declaration(Class(obo:CLM_1000026))
+Declaration(Class(obo:CLM_1000027))
+Declaration(Class(obo:CLM_1000031))
+Declaration(Class(obo:CLM_1000032))
+Declaration(Class(obo:CLM_1000041))
+Declaration(Class(obo:CLM_1000043))
+Declaration(Class(obo:CLM_1000046))
+Declaration(Class(obo:CLM_1000047))
+Declaration(Class(obo:CLM_1000052))
+Declaration(Class(obo:CLM_1000053))
+Declaration(Class(obo:CLM_1000054))
+Declaration(Class(obo:CLM_1000056))
+Declaration(Class(obo:CLM_1000059))
+Declaration(Class(obo:CLM_1000061))
+Declaration(Class(obo:CLM_1000063))
+Declaration(Class(obo:CLM_1000065))
+Declaration(Class(obo:CLM_1000066))
+Declaration(Class(obo:CLM_1000067))
+Declaration(Class(obo:CLM_1000068))
+Declaration(Class(obo:CLM_1000069))
+Declaration(Class(obo:CLM_1000070))
+Declaration(Class(obo:CLM_1000071))
+Declaration(Class(obo:CLM_1000072))
+Declaration(Class(obo:CLM_1000073))
+Declaration(Class(obo:CLM_1000074))
+Declaration(Class(obo:CLM_1000075))
+Declaration(Class(obo:CLM_1000079))
+Declaration(Class(obo:CLM_1000080))
+Declaration(Class(obo:CLM_1000081))
+Declaration(Class(obo:CLM_1000082))
+Declaration(Class(obo:CLM_1000083))
+Declaration(Class(obo:CLM_1000085))
Declaration(Class(obo:CL_0000000))
Declaration(Class(obo:CL_0000001))
Declaration(Class(obo:CL_0000002))
@@ -2643,6 +2684,7 @@ Declaration(Class(obo:CL_1001608))
Declaration(Class(obo:CL_1001609))
Declaration(Class(obo:CL_1001610))
Declaration(Class(obo:CL_1001611))
+Declaration(Class(obo:CL_1100001))
Declaration(Class(obo:CL_2000000))
Declaration(Class(obo:CL_2000001))
Declaration(Class(obo:CL_2000002))
@@ -3047,6 +3089,15 @@ Declaration(Class(obo:CL_4033081))
Declaration(Class(obo:CL_4033082))
Declaration(Class(obo:CL_4033083))
Declaration(Class(obo:CL_4033084))
+Declaration(Class(obo:CL_4033085))
+Declaration(Class(obo:CL_4033086))
+Declaration(Class(obo:CL_4033087))
+Declaration(Class(obo:CL_4033088))
+Declaration(Class(obo:CL_4033089))
+Declaration(Class(obo:CL_4033090))
+Declaration(Class(obo:CL_4033091))
+Declaration(Class(obo:CL_4033092))
+Declaration(Class(obo:CL_4033093))
Declaration(Class(obo:CL_4040000))
Declaration(Class(obo:CL_4040001))
Declaration(Class(obo:CL_4040002))
@@ -3081,6 +3132,20 @@ Declaration(Class(obo:CL_4042024))
Declaration(Class(obo:CL_4042025))
Declaration(Class(obo:CL_4042026))
Declaration(Class(obo:CL_4042027))
+Declaration(Class(obo:CL_4042028))
+Declaration(Class(obo:CL_4042029))
+Declaration(Class(obo:CL_4042030))
+Declaration(Class(obo:CL_4042031))
+Declaration(Class(obo:CL_4042032))
+Declaration(Class(obo:CL_4042033))
+Declaration(Class(obo:CL_4042034))
+Declaration(Class(obo:CL_4042035))
+Declaration(Class(obo:CL_4042036))
+Declaration(Class(obo:CL_4042037))
+Declaration(Class(obo:CL_4042038))
+Declaration(Class(obo:CL_4042039))
+Declaration(Class(obo:CL_4042040))
+Declaration(Class(obo:CL_4042041))
Declaration(Class(obo:CL_4047001))
Declaration(Class(obo:CL_4047002))
Declaration(Class(obo:CL_4047003))
@@ -3090,10 +3155,19 @@ Declaration(Class(obo:CL_4047006))
Declaration(Class(obo:CL_4047007))
Declaration(Class(obo:CL_4047011))
Declaration(Class(obo:CL_4047012))
+Declaration(Class(obo:CL_4047017))
Declaration(Class(obo:CL_4047018))
Declaration(Class(obo:CL_4047019))
+Declaration(Class(obo:CL_4047023))
+Declaration(Class(obo:CL_4047025))
+Declaration(Class(obo:CL_4047029))
+Declaration(Class(obo:CL_4047030))
+Declaration(Class(obo:CL_4047032))
+Declaration(Class(obo:CL_4047034))
+Declaration(Class(obo:CL_4047035))
Declaration(Class(obo:CL_4047051))
Declaration(Class(obo:CL_4047052))
+Declaration(Class(obo:CL_4047101))
Declaration(Class(obo:CL_4052001))
Declaration(Class(obo:CL_4052002))
Declaration(Class(obo:CL_4052003))
@@ -3105,14 +3179,36 @@ Declaration(Class(obo:CL_4052008))
Declaration(Class(obo:CL_4052009))
Declaration(Class(obo:CL_4052010))
Declaration(Class(obo:CL_4052011))
+Declaration(Class(obo:CL_4052012))
+Declaration(Class(obo:CL_4052013))
+Declaration(Class(obo:CL_4052014))
+Declaration(Class(obo:CL_4052015))
+Declaration(Class(obo:CL_4052016))
+Declaration(Class(obo:CL_4052017))
+Declaration(Class(obo:CL_4052018))
+Declaration(Class(obo:CL_4052019))
+Declaration(Class(obo:CL_4052020))
+Declaration(Class(obo:CL_4052021))
+Declaration(Class(obo:CL_4052022))
+Declaration(Class(obo:CL_4052023))
+Declaration(Class(obo:CL_4052024))
+Declaration(Class(obo:CL_4052025))
+Declaration(Class(obo:CL_4052026))
+Declaration(Class(obo:CL_4052027))
+Declaration(Class(obo:CL_4052028))
+Declaration(Class(obo:CL_4052029))
+Declaration(Class(obo:CL_4052030))
+Declaration(Class(obo:CL_4052031))
Declaration(Class(obo:CL_4052048))
Declaration(Class(obo:CL_4052049))
Declaration(Class(obo:GO_0000278))
Declaration(Class(obo:GO_0000768))
Declaration(Class(obo:GO_0000791))
Declaration(Class(obo:GO_0000792))
+Declaration(Class(obo:GO_0001552))
Declaration(Class(obo:GO_0001667))
Declaration(Class(obo:GO_0001675))
+Declaration(Class(obo:GO_0001696))
Declaration(Class(obo:GO_0001816))
Declaration(Class(obo:GO_0001820))
Declaration(Class(obo:GO_0001821))
@@ -3163,10 +3259,12 @@ Declaration(Class(obo:GO_0005576))
Declaration(Class(obo:GO_0005634))
Declaration(Class(obo:GO_0005730))
Declaration(Class(obo:GO_0005737))
+Declaration(Class(obo:GO_0005773))
Declaration(Class(obo:GO_0005794))
Declaration(Class(obo:GO_0005840))
Declaration(Class(obo:GO_0005902))
Declaration(Class(obo:GO_0005903))
+Declaration(Class(obo:GO_0005927))
Declaration(Class(obo:GO_0005929))
Declaration(Class(obo:GO_0006699))
Declaration(Class(obo:GO_0006909))
@@ -3201,6 +3299,7 @@ Declaration(Class(obo:GO_0016446))
Declaration(Class(obo:GO_0016477))
Declaration(Class(obo:GO_0017145))
Declaration(Class(obo:GO_0019226))
+Declaration(Class(obo:GO_0019626))
Declaration(Class(obo:GO_0019724))
Declaration(Class(obo:GO_0019814))
Declaration(Class(obo:GO_0019815))
@@ -3267,6 +3366,8 @@ Declaration(Class(obo:GO_0033380))
Declaration(Class(obo:GO_0034102))
Declaration(Class(obo:GO_0035010))
Declaration(Class(obo:GO_0035369))
+Declaration(Class(obo:GO_0035377))
+Declaration(Class(obo:GO_0035898))
Declaration(Class(obo:GO_0035929))
Declaration(Class(obo:GO_0035931))
Declaration(Class(obo:GO_0035933))
@@ -3315,6 +3416,7 @@ Declaration(Class(obo:GO_0045058))
Declaration(Class(obo:GO_0045087))
Declaration(Class(obo:GO_0045190))
Declaration(Class(obo:GO_0045191))
+Declaration(Class(obo:GO_0045428))
Declaration(Class(obo:GO_0045443))
Declaration(Class(obo:GO_0045453))
Declaration(Class(obo:GO_0045457))
@@ -3322,10 +3424,12 @@ Declaration(Class(obo:GO_0045580))
Declaration(Class(obo:GO_0045627))
Declaration(Class(obo:GO_0045630))
Declaration(Class(obo:GO_0045730))
+Declaration(Class(obo:GO_0045765))
Declaration(Class(obo:GO_0045766))
Declaration(Class(obo:GO_0045830))
Declaration(Class(obo:GO_0046649))
Declaration(Class(obo:GO_0046651))
+Declaration(Class(obo:GO_0046697))
Declaration(Class(obo:GO_0046717))
Declaration(Class(obo:GO_0046879))
Declaration(Class(obo:GO_0048103))
@@ -3341,6 +3445,7 @@ Declaration(Class(obo:GO_0050728))
Declaration(Class(obo:GO_0050729))
Declaration(Class(obo:GO_0050776))
Declaration(Class(obo:GO_0050777))
+Declaration(Class(obo:GO_0050893))
Declaration(Class(obo:GO_0050906))
Declaration(Class(obo:GO_0050907))
Declaration(Class(obo:GO_0050908))
@@ -3353,7 +3458,6 @@ Declaration(Class(obo:GO_0050976))
Declaration(Class(obo:GO_0051024))
Declaration(Class(obo:GO_0051321))
Declaration(Class(obo:GO_0051458))
-Declaration(Class(obo:GO_0051767))
Declaration(Class(obo:GO_0060047))
Declaration(Class(obo:GO_0060054))
Declaration(Class(obo:GO_0060096))
@@ -3392,6 +3496,8 @@ Declaration(Class(obo:GO_0090023))
Declaration(Class(obo:GO_0097186))
Declaration(Class(obo:GO_0097722))
Declaration(Class(obo:GO_0097729))
+Declaration(Class(obo:GO_0098522))
+Declaration(Class(obo:GO_0098535))
Declaration(Class(obo:GO_0098594))
Declaration(Class(obo:GO_0098754))
Declaration(Class(obo:GO_0098976))
@@ -3543,6 +3649,7 @@ Declaration(Class(obo:PR_000001402))
Declaration(Class(obo:PR_000001408))
Declaration(Class(obo:PR_000001412))
Declaration(Class(obo:PR_000001438))
+Declaration(Class(obo:PR_000001440))
Declaration(Class(obo:PR_000001444))
Declaration(Class(obo:PR_000001447))
Declaration(Class(obo:PR_000001456))
@@ -3630,6 +3737,7 @@ Declaration(Class(obo:PR_000003460))
Declaration(Class(obo:PR_000003463))
Declaration(Class(obo:PR_000003466))
Declaration(Class(obo:PR_000003469))
+Declaration(Class(obo:PR_000003472))
Declaration(Class(obo:PR_000003499))
Declaration(Class(obo:PR_000003516))
Declaration(Class(obo:PR_000004919))
@@ -3675,7 +3783,9 @@ Declaration(Class(obo:PR_000010543))
Declaration(Class(obo:PR_000010799))
Declaration(Class(obo:PR_000011178))
Declaration(Class(obo:PR_000011467))
+Declaration(Class(obo:PR_000012318))
Declaration(Class(obo:PR_000012526))
+Declaration(Class(obo:PR_000013015))
Declaration(Class(obo:PR_000013047))
Declaration(Class(obo:PR_000013433))
Declaration(Class(obo:PR_000013502))
@@ -3693,6 +3803,7 @@ Declaration(Class(obo:PR_000015665))
Declaration(Class(obo:PR_000016004))
Declaration(Class(obo:PR_000016043))
Declaration(Class(obo:PR_000016401))
+Declaration(Class(obo:PR_000016626))
Declaration(Class(obo:PR_000017298))
Declaration(Class(obo:PR_000017299))
Declaration(Class(obo:PR_000022006))
@@ -3700,7 +3811,6 @@ Declaration(Class(obo:PR_000025402))
Declaration(Class(obo:PR_000025403))
Declaration(Class(obo:PR_000032148))
Declaration(Class(obo:PR_000032533))
-Declaration(Class(obo:PR_000050567))
Declaration(Class(obo:PR_O43699))
Declaration(Class(obo:PR_O76036))
Declaration(Class(obo:PR_O95944))
@@ -3759,6 +3869,9 @@ Declaration(Class(obo:UBERON_0000114))
Declaration(Class(obo:UBERON_0000115))
Declaration(Class(obo:UBERON_0000121))
Declaration(Class(obo:UBERON_0000122))
+Declaration(Class(obo:UBERON_0000155))
+Declaration(Class(obo:UBERON_0000156))
+Declaration(Class(obo:UBERON_0000157))
Declaration(Class(obo:UBERON_0000159))
Declaration(Class(obo:UBERON_0000160))
Declaration(Class(obo:UBERON_0000173))
@@ -3776,6 +3889,7 @@ Declaration(Class(obo:UBERON_0000378))
Declaration(Class(obo:UBERON_0000391))
Declaration(Class(obo:UBERON_0000395))
Declaration(Class(obo:UBERON_0000397))
+Declaration(Class(obo:UBERON_0000400))
Declaration(Class(obo:UBERON_0000403))
Declaration(Class(obo:UBERON_0000412))
Declaration(Class(obo:UBERON_0000423))
@@ -3784,6 +3898,7 @@ Declaration(Class(obo:UBERON_0000437))
Declaration(Class(obo:UBERON_0000473))
Declaration(Class(obo:UBERON_0000478))
Declaration(Class(obo:UBERON_0000479))
+Declaration(Class(obo:UBERON_0000482))
Declaration(Class(obo:UBERON_0000483))
Declaration(Class(obo:UBERON_0000916))
Declaration(Class(obo:UBERON_0000922))
@@ -3838,9 +3953,9 @@ Declaration(Class(obo:UBERON_0001156))
Declaration(Class(obo:UBERON_0001157))
Declaration(Class(obo:UBERON_0001158))
Declaration(Class(obo:UBERON_0001159))
-Declaration(Class(obo:UBERON_0001160))
Declaration(Class(obo:UBERON_0001178))
Declaration(Class(obo:UBERON_0001179))
+Declaration(Class(obo:UBERON_0001206))
Declaration(Class(obo:UBERON_0001211))
Declaration(Class(obo:UBERON_0001212))
Declaration(Class(obo:UBERON_0001213))
@@ -3855,7 +3970,6 @@ Declaration(Class(obo:UBERON_0001236))
Declaration(Class(obo:UBERON_0001237))
Declaration(Class(obo:UBERON_0001238))
Declaration(Class(obo:UBERON_0001241))
-Declaration(Class(obo:UBERON_0001242))
Declaration(Class(obo:UBERON_0001243))
Declaration(Class(obo:UBERON_0001249))
Declaration(Class(obo:UBERON_0001250))
@@ -3881,7 +3995,6 @@ Declaration(Class(obo:UBERON_0001291))
Declaration(Class(obo:UBERON_0001292))
Declaration(Class(obo:UBERON_0001293))
Declaration(Class(obo:UBERON_0001294))
-Declaration(Class(obo:UBERON_0001295))
Declaration(Class(obo:UBERON_0001296))
Declaration(Class(obo:UBERON_0001301))
Declaration(Class(obo:UBERON_0001305))
@@ -4092,6 +4205,7 @@ Declaration(Class(obo:UBERON_0002363))
Declaration(Class(obo:UBERON_0002364))
Declaration(Class(obo:UBERON_0002365))
Declaration(Class(obo:UBERON_0002367))
+Declaration(Class(obo:UBERON_0002368))
Declaration(Class(obo:UBERON_0002369))
Declaration(Class(obo:UBERON_0002370))
Declaration(Class(obo:UBERON_0002371))
@@ -4107,6 +4221,7 @@ Declaration(Class(obo:UBERON_0002410))
Declaration(Class(obo:UBERON_0002412))
Declaration(Class(obo:UBERON_0002418))
Declaration(Class(obo:UBERON_0002419))
+Declaration(Class(obo:UBERON_0002420))
Declaration(Class(obo:UBERON_0002421))
Declaration(Class(obo:UBERON_0002424))
Declaration(Class(obo:UBERON_0002435))
@@ -4118,6 +4233,7 @@ Declaration(Class(obo:UBERON_0002485))
Declaration(Class(obo:UBERON_0002506))
Declaration(Class(obo:UBERON_0002512))
Declaration(Class(obo:UBERON_0002521))
+Declaration(Class(obo:UBERON_0002530))
Declaration(Class(obo:UBERON_0002548))
Declaration(Class(obo:UBERON_0002707))
Declaration(Class(obo:UBERON_0002829))
@@ -4134,6 +4250,7 @@ Declaration(Class(obo:UBERON_0003214))
Declaration(Class(obo:UBERON_0003241))
Declaration(Class(obo:UBERON_0003242))
Declaration(Class(obo:UBERON_0003244))
+Declaration(Class(obo:UBERON_0003335))
Declaration(Class(obo:UBERON_0003354))
Declaration(Class(obo:UBERON_0003367))
Declaration(Class(obo:UBERON_0003422))
@@ -4165,6 +4282,7 @@ Declaration(Class(obo:UBERON_0004026))
Declaration(Class(obo:UBERON_0004044))
Declaration(Class(obo:UBERON_0004059))
Declaration(Class(obo:UBERON_0004088))
+Declaration(Class(obo:UBERON_0004119))
Declaration(Class(obo:UBERON_0004120))
Declaration(Class(obo:UBERON_0004121))
Declaration(Class(obo:UBERON_0004129))
@@ -4228,7 +4346,6 @@ Declaration(Class(obo:UBERON_0004823))
Declaration(Class(obo:UBERON_0004872))
Declaration(Class(obo:UBERON_0004880))
Declaration(Class(obo:UBERON_0004903))
-Declaration(Class(obo:UBERON_0004997))
Declaration(Class(obo:UBERON_0005096))
Declaration(Class(obo:UBERON_0005097))
Declaration(Class(obo:UBERON_0005099))
@@ -4256,7 +4373,6 @@ Declaration(Class(obo:UBERON_0005271))
Declaration(Class(obo:UBERON_0005310))
Declaration(Class(obo:UBERON_0005317))
Declaration(Class(obo:UBERON_0005329))
-Declaration(Class(obo:UBERON_0005357))
Declaration(Class(obo:UBERON_0005375))
Declaration(Class(obo:UBERON_0005376))
Declaration(Class(obo:UBERON_0005377))
@@ -4293,7 +4409,7 @@ Declaration(Class(obo:UBERON_0006334))
Declaration(Class(obo:UBERON_0006341))
Declaration(Class(obo:UBERON_0006376))
Declaration(Class(obo:UBERON_0006725))
-Declaration(Class(obo:UBERON_0006799))
+Declaration(Class(obo:UBERON_0006761))
Declaration(Class(obo:UBERON_0006815))
Declaration(Class(obo:UBERON_0006841))
Declaration(Class(obo:UBERON_0006851))
@@ -4311,6 +4427,7 @@ Declaration(Class(obo:UBERON_0007100))
Declaration(Class(obo:UBERON_0007177))
Declaration(Class(obo:UBERON_0007196))
Declaration(Class(obo:UBERON_0007221))
+Declaration(Class(obo:UBERON_0007240))
Declaration(Class(obo:UBERON_0007376))
Declaration(Class(obo:UBERON_0007589))
Declaration(Class(obo:UBERON_0007846))
@@ -4318,6 +4435,7 @@ Declaration(Class(obo:UBERON_0008198))
Declaration(Class(obo:UBERON_0008266))
Declaration(Class(obo:UBERON_0008305))
Declaration(Class(obo:UBERON_0008339))
+Declaration(Class(obo:UBERON_0008345))
Declaration(Class(obo:UBERON_0008346))
Declaration(Class(obo:UBERON_0008397))
Declaration(Class(obo:UBERON_0008404))
@@ -4363,9 +4481,11 @@ Declaration(Class(obo:UBERON_0009969))
Declaration(Class(obo:UBERON_0009970))
Declaration(Class(obo:UBERON_0009971))
Declaration(Class(obo:UBERON_0010005))
+Declaration(Class(obo:UBERON_0010038))
Declaration(Class(obo:UBERON_0010077))
Declaration(Class(obo:UBERON_0010225))
Declaration(Class(obo:UBERON_0010302))
+Declaration(Class(obo:UBERON_0010313))
Declaration(Class(obo:UBERON_0010397))
Declaration(Class(obo:UBERON_0010402))
Declaration(Class(obo:UBERON_0010403))
@@ -4391,6 +4511,7 @@ Declaration(Class(obo:UBERON_0012399))
Declaration(Class(obo:UBERON_0012419))
Declaration(Class(obo:UBERON_0012429))
Declaration(Class(obo:UBERON_0012441))
+Declaration(Class(obo:UBERON_0012498))
Declaration(Class(obo:UBERON_0013192))
Declaration(Class(obo:UBERON_0013485))
Declaration(Class(obo:UBERON_0013486))
@@ -4410,8 +4531,10 @@ Declaration(Class(obo:UBERON_0014451))
Declaration(Class(obo:UBERON_0014727))
Declaration(Class(obo:UBERON_0014729))
Declaration(Class(obo:UBERON_0015172))
+Declaration(Class(obo:UBERON_0015716))
Declaration(Class(obo:UBERON_0015766))
Declaration(Class(obo:UBERON_0016405))
+Declaration(Class(obo:UBERON_0022281))
Declaration(Class(obo:UBERON_0022315))
Declaration(Class(obo:UBERON_0027368))
Declaration(Class(obo:UBERON_0027371))
@@ -4491,6 +4614,7 @@ Declaration(ObjectProperty(obo:RO_0002596))
Declaration(ObjectProperty(obo:RO_0003000))
Declaration(ObjectProperty(obo:RO_0013001))
Declaration(ObjectProperty(obo:RO_0013007))
+Declaration(ObjectProperty(obo:RO_0015004))
Declaration(ObjectProperty(obo:RO_0015015))
Declaration(ObjectProperty(obo:RO_0015016))
Declaration(AnnotationProperty(obo:IAO_0000028))
@@ -4504,8 +4628,8 @@ Declaration(AnnotationProperty(obo:IAO_0100001))
Declaration(AnnotationProperty(obo:RO_0002161))
Declaration(AnnotationProperty(obo:RO_0002175))
Declaration(AnnotationProperty(obo:RO_0004050))
-Declaration(AnnotationProperty(dc:date))
Declaration(AnnotationProperty(dc:description))
+Declaration(AnnotationProperty(dc:license))
Declaration(AnnotationProperty(dc:title))
Declaration(AnnotationProperty(dc:type))
Declaration(AnnotationProperty(terms:contributor))
@@ -4514,9 +4638,7 @@ Declaration(AnnotationProperty(terms:description))
Declaration(AnnotationProperty(terms:license))
Declaration(AnnotationProperty(oboInOwl:SynonymTypeProperty))
Declaration(AnnotationProperty(oboInOwl:consider))
-Declaration(AnnotationProperty(oboInOwl:created_by))
Declaration(AnnotationProperty(oboInOwl:creation_date))
-Declaration(AnnotationProperty(oboInOwl:hasAlternativeId))
Declaration(AnnotationProperty(oboInOwl:hasBroadSynonym))
Declaration(AnnotationProperty(oboInOwl:hasDbXref))
Declaration(AnnotationProperty(oboInOwl:hasExactSynonym))
@@ -4527,7 +4649,6 @@ Declaration(AnnotationProperty(oboInOwl:hasSynonymType))
Declaration(AnnotationProperty(oboInOwl:id))
Declaration(AnnotationProperty(oboInOwl:inSubset))
Declaration(AnnotationProperty(oboInOwl:is_inferred))
-Declaration(AnnotationProperty(oboInOwl:note))
Declaration(AnnotationProperty(oboInOwl:source))
Declaration(AnnotationProperty(foaf:depiction))
Declaration(AnnotationProperty(sssom:mapping_justification))
@@ -4610,7 +4731,6 @@ AnnotationAssertion(obo:IAO_0000233 obo:CL_0000003 ) oboInOwl:hasDbXref obo:CL_0000019 "ZFA:0009006")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000019 "https://cellxgene.cziscience.com/cellguide/CL_0000019")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000019 "sperm cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000019 "spermatozoid")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000019 "spermatozoon")
@@ -4903,7 +5035,7 @@ SubClassOf(obo:CL_0000027 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000008))
AnnotationAssertion(rdfs:label obo:CL_0000028 "CNS neuron (sensu Nematoda and Protostomia)")
SubClassOf(obo:CL_0000028 obo:BFO_0000002)
-SubClassOf(obo:CL_0000028 obo:CL_0000540)
+SubClassOf(obo:CL_0000028 obo:CL_2000029)
SubClassOf(obo:CL_0000028 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001017))
SubClassOf(obo:CL_0000028 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000338))
@@ -4920,6 +5052,7 @@ SubClassOf(obo:CL_0000029 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002676))
# Class: obo:CL_0000030 (glioblast)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37824650") Annotation(oboInOwl:hasDbXref "Wikipedia:Glioblast") obo:IAO_0000115 obo:CL_0000030 "A non-terminally differentiated cell that develops form the neuroectoderm. Glioblast has the potential to differentiate into various types of glial cells, including astrocytes and oligodendrocytes.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000030 "ZFA:0009010")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000030 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000030 "glioblast")
@@ -5082,7 +5215,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000040 "monoblast")
EquivalentClasses(obo:CL_0000040 ObjectIntersectionOf(obo:CL_0002194 ObjectSomeValuesFrom(obo:BFO_0000051 obo:CL_0017503) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0000791) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005730) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0030224)))
SubClassOf(obo:CL_0000040 obo:CL_0000763)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000040 obo:CL_0002194)
-SubClassOf(obo:CL_0000040 obo:PR_000050567)
SubClassOf(obo:CL_0000040 ObjectSomeValuesFrom(obo:BFO_0000051 obo:CL_0017503))
SubClassOf(obo:CL_0000040 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0000791))
SubClassOf(obo:CL_0000040 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005730))
@@ -5128,7 +5260,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000042 "neutrophilic myeloblast")
EquivalentClasses(obo:CL_0000042 ObjectIntersectionOf(obo:CL_0000835 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001944) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000005307) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007857) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000010799) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000014362) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0030223)))
SubClassOf(obo:CL_0000042 obo:CL_0000834)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000042 obo:CL_0000835)
-SubClassOf(obo:CL_0000042 obo:PR_000050567)
SubClassOf(obo:CL_0000042 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001944))
SubClassOf(obo:CL_0000042 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000005307))
SubClassOf(obo:CL_0000042 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007857))
@@ -5320,6 +5451,7 @@ AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000056 "ZFA:0009025")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000056 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000056 "myoblast")
SubClassOf(obo:CL_0000056 obo:CL_0000680)
@@ -5338,9 +5470,7 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0000057 cl:general_cell_types_upper
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000057 core:human_reference_atlas)
AnnotationAssertion(rdfs:comment obo:CL_0000057 "These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.")
AnnotationAssertion(rdfs:label obo:CL_0000057 "fibroblast")
-SubClassOf(obo:CL_0000057 obo:BFO_0000002)
-SubClassOf(obo:CL_0000057 obo:CL_0002320)
-SubClassOf(obo:CL_0000057 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000134))
+SubClassOf(obo:CL_0000057 obo:CL_0000499)
# Class: obo:CL_0000058 (chondroblast)
@@ -5366,8 +5496,8 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000059 "enamel secreting ce
AnnotationAssertion(rdfs:comment obo:CL_0000059 "non-encoded relationship from VSAO produces VSAO:0000066")
AnnotationAssertion(rdfs:label obo:CL_0000059 "ameloblast")
SubClassOf(obo:CL_0000059 obo:CL_0000146)
-SubClassOf(obo:CL_0000059 obo:CL_0000151)
SubClassOf(obo:CL_0000059 obo:CL_0002077)
+SubClassOf(obo:CL_0000059 obo:CL_1100001)
SubClassOf(obo:CL_0000059 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005176))
SubClassOf(obo:CL_0000059 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0007000))
SubClassOf(obo:CL_0000059 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0097186))
@@ -5443,7 +5573,6 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0000064 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000064 "ciliated cell")
EquivalentClasses(obo:CL_0000064 ObjectIntersectionOf(obo:CL_0000000 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005929)))
SubClassOf(obo:CL_0000064 obo:CL_0000255)
-SubClassOf(obo:CL_0000064 obo:PR_000050567)
SubClassOf(obo:CL_0000064 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005929))
# Class: obo:CL_0000065 (ependymal cell)
@@ -5457,7 +5586,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.53347/rID-51713") oboI
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000065 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000065 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0000065 "ependymal cell")
-EquivalentClasses(obo:CL_0000065 ObjectIntersectionOf(obo:CL_0000710 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004670)))
+EquivalentClasses(obo:CL_0000065 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004670)))
SubClassOf(obo:CL_0000065 obo:CL_0000067)
SubClassOf(obo:CL_0000065 obo:CL_0000125)
SubClassOf(obo:CL_0000065 obo:CL_0000710)
@@ -5641,6 +5770,7 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000083 "BTO:0000028")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000083 "ZFA:0009045")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000083 "pancreas epithelial cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000083 "pancreatic epithelial cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000083 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000083 "epithelial cell of pancreas")
EquivalentClasses(obo:CL_0000083 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001264)))
SubClassOf(obo:CL_0000083 obo:CL_0002076)
@@ -5723,7 +5853,7 @@ AnnotationAssertion(owl:deprecated obo:CL_0000090 "true"^^xsd:boolean)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:add") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") Annotation(oboInOwl:hasDbXref "MESH:D007728") Annotation(oboInOwl:hasDbXref "PMID:15771589") Annotation(oboInOwl:hasDbXref "PMID:17105582") obo:IAO_0000115 obo:CL_0000091 "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000091 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/cphy.c120026") Annotation(oboInOwl:hasDbXref "DOI:10.1007/978-1-4939-1311-4_10") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.immuni.2022.08.002") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri.2017.11") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1478-3231.2006.01342.x") terms:description obo:CL_0000091 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/cphy.c120026") Annotation(oboInOwl:hasDbXref "DOI:10.1007/978-1-4939-1311-4_10") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.immuni.2022.08.002") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri.2017.11") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1478-3231.2006.01342.x") terms:description obo:CL_0000091 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Kupffer cells are tissue-resident macrophages located in the liver. They are an integral part of the mononuclear phagocyte system and are responsible for the phagocytosis of dead or dying cells, microbes, and other foreign substances. Kupffer cells account for approximately 80-90% of tissue-resident macrophages in the body. They are found within the lumen of liver sinusoids and interface with microbial populations and products.
The primary role of Kupffer cells is to maintain homeostasis in the liver. They continuously filter and cleanse the blood that flows through the liver, removing pathogens, endotoxins, particulate matter, aged and dysfunctional red blood cells, and miscellaneous waste products. These cells also play an important role in maintaining iron homeostasis. During the process of phagocytosis, Kupffer cells recycle iron from degraded red blood cells, which is then utilized in the formation of new erythrocytes.
@@ -5743,7 +5873,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000091 "Markers: Mouse: F4/80+, CD11b-l
AnnotationAssertion(rdfs:label obo:CL_0000091 "Kupffer cell")
EquivalentClasses(obo:CL_0000091 ObjectIntersectionOf(obo:CL_0000864 ObjectSomeValuesFrom(obo:RO_0001025 obo:UBERON_0001281) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001813) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001925) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002064) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0034102) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001012)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000091 obo:CL_0000864)
-SubClassOf(obo:CL_0000091 obo:PR_000050567)
SubClassOf(obo:CL_0000091 ObjectSomeValuesFrom(obo:RO_0001025 obo:UBERON_0001281))
SubClassOf(obo:CL_0000091 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001813))
SubClassOf(obo:CL_0000091 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001925))
@@ -5754,11 +5883,16 @@ SubClassOf(obo:CL_0000091 ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001012))
# Class: obo:CL_0000092 (osteoclast)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:add") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "ISBN:0781735149") Annotation(oboInOwl:hasDbXref "PMID:10428500") Annotation(oboInOwl:hasDbXref "PMID:15055519") Annotation(oboInOwl:hasDbXref "PMID:17380158") obo:IAO_0000115 obo:CL_0000092 "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.3389/fmed.2017.00234") Annotation(oboInOwl:hasDbXref "DOI:10.37175/stemedicine.v1i4.57") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/medicine-and-dentistry/osteoclast") terms:description obo:CL_0000092 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Osteoclasts, derived from the monocyte/macrophage lineage, play a crucial role in bone remodeling through bone resorption. They are distinguished from other cells by their large size and their unique ability to secrete enzymes and acids that dissolve the calcium phosphate in bone. The formation of osteoclasts is influenced by two primary factors: macrophage colony-stimulating factor (M-CSF) and the ligand-activated receptor (RANKL) of nuclear factor kappa B (NF-κB).
+Osteoclasts also collaborate with osteoblasts, responsible for new bone formation, to maintain bone health and adapt bone structure. Their coordinated actions allow continuous remodeling while preserving overall bone strength and integrity. Imbalances in osteoclast activity can lead to pathological conditions. For example, excessive activity may contribute to diseases like osteoporosis, periprosthetic osteolysis, bone tumors, and Paget's disease. Other the other hand, osteoclast deficiency ca result in conditions like osteopetrosis.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000092 "BTO:0000968")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000092 "CALOHA:TS-0721")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000092 "FMA:66781")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000092 "MESH:D010010")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000092 "ZFA:0009047")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000092 "https://cellxgene.cziscience.com/cellguide/CL_0000092")
AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_0000092 "chondroclast")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000092 cl:cellxgene_subset)
AnnotationAssertion(rdfs:comment obo:CL_0000092 "Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.")
@@ -5767,7 +5901,6 @@ EquivalentClasses(obo:CL_0000092 ObjectIntersectionOf(obo:CL_0000766 ObjectSomeV
SubClassOf(obo:CL_0000092 obo:CL_0000518)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000092 obo:CL_0000766)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000092 obo:CL_0001035)
-SubClassOf(obo:CL_0000092 obo:PR_000050567)
SubClassOf(obo:CL_0000092 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001850))
SubClassOf(obo:CL_0000092 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001937))
SubClassOf(obo:CL_0000092 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001944))
@@ -5803,7 +5936,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000094 "granulocyte")
EquivalentClasses(obo:CL_0000094 ObjectIntersectionOf(obo:CL_0000766 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0030141) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001332) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001969) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0008015)))
SubClassOf(obo:CL_0000094 obo:CL_0000081)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000094 obo:CL_0000766)
-SubClassOf(obo:CL_0000094 obo:PR_000050567)
SubClassOf(obo:CL_0000094 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0030141))
SubClassOf(obo:CL_0000094 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002))
SubClassOf(obo:CL_0000094 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020))
@@ -5880,7 +6012,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000097 "mast cell")
EquivalentClasses(obo:CL_0000097 ObjectIntersectionOf(obo:CL_0000766 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0030141) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001865) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001255) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000006169) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002349) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002539) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002660) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002690) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002830) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0030210) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000002065) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000007431)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000097 obo:CL_0000766)
SubClassOf(obo:CL_0000097 obo:CL_0002274)
-SubClassOf(obo:CL_0000097 obo:PR_000050567)
SubClassOf(obo:CL_0000097 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0030141))
SubClassOf(obo:CL_0000097 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001865))
SubClassOf(obo:CL_0000097 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001255))
@@ -5916,10 +6047,11 @@ AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000099 "ZFA:0009051")
+AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_0000099 "CNS interneuron")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000099 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000099 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0000099 "interneuron")
-SubClassOf(obo:CL_0000099 obo:CL_0000540)
+SubClassOf(obo:CL_0000099 obo:CL_2000029)
# Class: obo:CL_0000100 (motor neuron)
@@ -5946,6 +6078,7 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000101 "FMA:84649")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000101 "MESH:D011984")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000101 "WBbt:0005759")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000101 "ZFA:0009053")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000101 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000101 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0000101 "sensory neuron")
EquivalentClasses(obo:CL_0000101 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050906)))
@@ -5954,9 +6087,11 @@ SubClassOf(obo:CL_0000101 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050906))
# Class: obo:CL_0000102 (polymodal neuron)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:23749412") Annotation(oboInOwl:hasDbXref "PMID:36381588") obo:IAO_0000115 obo:CL_0000102 "A neuron type that respond to multiple stimuli such as mechanical, thermal and chemical. This neuron type is responsible for integrating different types of sensory inputs, allowing organisms to respond appropriately to diverse environmental challenges.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000102 "ZFA:0009054")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:23749412") oboInOwl:hasRelatedSynonym obo:CL_0000102 "polymodal sensory neuron")
AnnotationAssertion(rdfs:label obo:CL_0000102 "polymodal neuron")
-SubClassOf(obo:CL_0000102 obo:CL_0000540)
+SubClassOf(obo:CL_0000102 obo:CL_2000032)
# Class: obo:CL_0000103 (bipolar neuron)
@@ -5977,8 +6112,7 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000104 "FMA:67287")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000104 "ZFA:0009056")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000104 cl:BDS_subset)
AnnotationAssertion(rdfs:label obo:CL_0000104 "multipolar neuron")
-EquivalentClasses(obo:CL_0000104 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070026)))
-SubClassOf(obo:CL_0000104 obo:CL_0000540)
+SubClassOf(obo:CL_0000104 obo:CL_2000029)
SubClassOf(obo:CL_0000104 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070026))
# Class: obo:CL_0000105 (pseudounipolar neuron)
@@ -5987,7 +6121,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:67305") Annotation(oboInO
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000105 "FMA:67305")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000105 "ZFA:0009057")
AnnotationAssertion(rdfs:label obo:CL_0000105 "pseudounipolar neuron")
-SubClassOf(obo:CL_0000105 obo:CL_0000540)
+SubClassOf(obo:CL_0000105 obo:CL_2000032)
# Class: obo:CL_0000106 (unipolar neuron)
@@ -5996,7 +6130,7 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000106 "FMA:67278")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000106 "ZFA:0009058")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000106 cl:BDS_subset)
AnnotationAssertion(rdfs:label obo:CL_0000106 "unipolar neuron")
-SubClassOf(obo:CL_0000106 obo:CL_0000540)
+SubClassOf(obo:CL_0000106 obo:CL_2000032)
# Class: obo:CL_0000107 (autonomic neuron)
@@ -6052,15 +6186,18 @@ AnnotationAssertion(owl:deprecated obo:CL_0000111 "true"^^xsd:boolean)
# Class: obo:CL_0000112 (columnar neuron)
-AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_0000112 "columnar neuron")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34696823") Annotation(oboInOwl:hasDbXref "PMID:37608556") obo:IAO_0000115 obo:CL_0000112 "A neuron of the invertebrate central nervous system. This neuron innervates the central complex (CX) of an invertebrate brain and it forms columnar patterns with its dendrites. It is involved in navigation and spatial processing.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18837039") Annotation(oboInOwl:hasDbXref "PMID:32374034") Annotation(oboInOwl:hasDbXref "PMID:34696823") Annotation(oboInOwl:hasDbXref "PMID:37608556") Annotation(oboInOwl:hasDbXref "PMID:9153131") rdfs:comment obo:CL_0000112 "Columnar neurons have been widely studied in Diptera, locusts, honey bees and other insects. In the mammalian brain, a \"columnar organisation\" is referred to neurons of the neocortex, however these differ from columnar neurons which are found in the insects central nervous system.")
AnnotationAssertion(rdfs:label obo:CL_0000112 "columnar neuron")
-SubClassOf(obo:CL_0000112 obo:CL_0000540)
+SubClassOf(obo:CL_0000112 obo:CL_0000028)
+SubClassOf(obo:CL_0000112 obo:CL_0008028)
+SubClassOf(obo:CL_0000112 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0007601))
# Class: obo:CL_0000113 (mononuclear phagocyte)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:add") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0781735149") obo:IAO_0000115 obo:CL_0000113 "A vertebrate phagocyte with a single nucleus.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000113 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.coi.2005.11.008") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri3087") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2019.01893") terms:description obo:CL_0000113 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.coi.2005.11.008") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri3087") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2019.01893") terms:description obo:CL_0000113 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Mononuclear phagocytes are immune cells that form a critical part of the body's innate immune system, the body's first line of defense against infections. Mononuclear phagocytes are characterized by the presence of a single, large nucleus. The ‘Mononuclear Phagocyte System’ nomenclature was introduced to distinguish mononuclear monocytes and macrophages from other cells with multiple nuclei. However, the cells within the mononuclear phagocyte system represent a highly heterogeneous group, all of which are able to perform highly efficient phagocytosis - engulfing and digesting microbes and cellular debris to fight infections and to maintain normal tissue homeostasis.
In addition to phagocytosis, mononuclear phagocytes also secrete chemical compounds to recruit other immune cells to a site of infection. These cells produce different types of signaling molecules, including cytokines, chemokines, and reactive oxygen species, triggering a cascade of responses to ensure rapid and efficient containment and neutralization of invading pathogens. These cells are also involved in antigen presentation, a process essential for stimulating an adaptive immune response. They can process and present antigens to T cells, thereby linking the innate and adaptive immune responses.
@@ -6077,7 +6214,12 @@ SubClassOf(obo:CL_0000113 obo:CL_0000842)
# Class: obo:CL_0000114 (surface ectodermal cell)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/srep32007") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK539836/") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK563130") terms:description obo:CL_0000114 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Surface ectoderm cells give rise to external structures such as the epidermis, hair, nails, and sweat glands. They are critical during the early stages of embryonic development, where they delineate and create the organism's exterior body plan. Beyond forming the organism's physical exterior, surface ectodermal cells have other significant roles. For instance, these cells lead to the development of the anterior pituitary gland and the enamel of the teeth. They are also integral to the formation of the sensory organs, including the eyes and the ears. In the eyes, they form the cornea and lens epithelium. In the ears, they form the external ear canal and certain parts of the inner ear. Therefore, these cells are instrumental in the development of various sensory systems in an organism.
+Certain abnormalities or mutations in surface ectodermal cells could lead to medical conditions known as ectodermal dysplasias. These are a group of inherited disorders affecting the development or function of teeth, hair, nails, and sweat glands. Therefore, understanding the formation and function of surface ectodermal cells is also important in identifying and addressing certain genetic disorders and conditions. In summary, surface ectodermal cells are essential in embryonic development, contributing to the creation of the external physical appearance and the sensory organs of an organism.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000114 "FMA:72552")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000114 "https://cellxgene.cziscience.com/cellguide/CL_0000114")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000114 "cell of surface ectoderm")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000114 "surface ectoderm cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000114 cl:cellxgene_subset)
@@ -6114,10 +6256,8 @@ SubClassOf(obo:CL_0000116 obo:CL_0000540)
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000117 "ZFA:0009067")
AnnotationAssertion(rdfs:label obo:CL_0000117 "CNS neuron (sensu Vertebrata)")
-SubClassOf(obo:CL_0000117 obo:BFO_0000002)
-SubClassOf(obo:CL_0000117 obo:CL_0000540)
+SubClassOf(obo:CL_0000117 obo:CL_2000029)
SubClassOf(obo:CL_0000117 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001017))
-SubClassOf(obo:CL_0000117 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000031))
# Class: obo:CL_0000118 (basket cell)
@@ -6127,7 +6267,6 @@ AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000120 "ZFA:0009070")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000120 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000120 "granule cell")
-SubClassOf(obo:CL_0000120 obo:CL_0000117)
+SubClassOf(obo:CL_0000120 obo:CL_2000029)
# Class: obo:CL_0000121 (Purkinje cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MESH:D011689") Annotation(oboInOwl:hasDbXref "PMID:12907269") Annotation(oboInOwl:hasDbXref "PMID:14568361") Annotation(oboInOwl:hasDbXref "PMID:31424738") Annotation(oboInOwl:hasDbXref "PMID:33288911") Annotation(oboInOwl:hasDbXref "PMID:38168772") obo:IAO_0000115 obo:CL_0000121 "An inhibitory neuron and the sole output neuron of the cerebellar cortex, the Purkinje cell's soma is located between the granular and molecular layers of the cerebellum. It is one of the largest neural cells in the mammalian brain, ranging from 50 to 80 micrometres in diameter. Purkinje cells have planar, fan-shaped dendrites that branch extensively with little overlap. This cell type receives synaptic input from parallel fibres, which modulate high-frequency spike activity known as \"simple spikes,\" and climbing fibres, which modulate infrequent calcium spike activity known as \"complex spikes\". Purkinje cells are involved in motor coordination, particularly in correcting movements in progress.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s12311-018-0985-7") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrn3886") Annotation(oboInOwl:hasDbXref "DOI:10.7554/eLife.63668") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK545154/") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/purkinje-cell") terms:description obo:CL_0000121 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s12311-018-0985-7") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrn3886") Annotation(oboInOwl:hasDbXref "DOI:10.7554/eLife.63668") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK545154/") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/purkinje-cell") terms:description obo:CL_0000121 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Purkinje cells, named after the Czech anatomist Jan Evangelista Purkyně who discovered them, are unique inhibitory neurons in the cerebellar cortex. They are a critical part of the vertebrate nervous system as they provide the only signal output from the cortex to the cerebellar nuclei. They are one of the few types of neurons that are large enough to be seen with the naked eye. The most distinct hallmark of Purkinje cells is their elaborate dendritic arbor, which forms a broad and intricately branching structure resembling a tree. These numerous branches each receive excitatory synaptic inputs from more than 100,000 parallel fibers; in addition, a single climbing fiber makes hundreds of synapses to the soma and proximal dendrites. A single long axon forms an inhibitory projection to the cerebellar nuclei.
Purkinje cells play key roles in the coordination of fine, voluntary motor movements and balance. As the sole output of all motor coordination in the cerebellar cortex, they serve as a central relay in the cerebro-cerebellar loop. Each Purkinje cell receives two types of synaptic input: one from parallel fibers (which are axons of granule cells), and the other from climbing fibers (originating from the inferior olivary nucleus). The Purkinje cells process and integrate these diverse kinds of input signals to generate output that controls timing and coordination of movements.
@@ -6174,8 +6313,6 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:28821816") Annotation(ob
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000121 cl:cellxgene_subset)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:17535929") Annotation(oboInOwl:hasDbXref "PMID:27215193") Annotation(oboInOwl:hasDbXref "PMID:37426070") Annotation(oboInOwl:hasDbXref "https://doi.org/10.1016/j.stem.2023.11.013") rdfs:comment obo:CL_0000121 "Neurodegenerative disorders affecting Purkinje cells disrupt motor functions. Some of the neurodegenerative disorders that causes loss and degeration of Purkinje cells are Spinocerebellar ataxias (SCAs) (Josef P Kapfhammer and Etsuko Shimobayashi 2023), Friedreich's ataxia (FRDA) (Kevin C Kemp et al., 2016), Fetal alcohol syndrome (Laurent Servais et al., 2016), Dandy-Walker malformation (Alexander Atamian et al., 2024).")
AnnotationAssertion(rdfs:label obo:CL_0000121 "Purkinje cell")
-SubClassOf(obo:CL_0000121 obo:CL_0000117)
-SubClassOf(obo:CL_0000121 obo:CL_0000527)
SubClassOf(obo:CL_0000121 obo:CL_1001611)
SubClassOf(obo:CL_0000121 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002129))
@@ -6187,9 +6324,8 @@ AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000129 "ZFA:0009077")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000129 "https://cellxgene.cziscience.com/cellguide/CL_0000129")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000129 "brain-resident macrophage")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "http://www.copewithcytokines.de/") oboInOwl:hasExactSynonym obo:CL_0000129 "hortega cells")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "http://www.copewithcytokines.de/") oboInOwl:hasExactSynonym obo:CL_0000129 "microgliocyte")
@@ -6302,7 +6446,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000129 "microglial cell")
EquivalentClasses(obo:CL_0000129 ObjectIntersectionOf(obo:CL_0000125 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001017) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001813) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002064) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0045087)))
SubClassOf(obo:CL_0000129 obo:CL_0000125)
SubClassOf(obo:CL_0000129 obo:CL_0000878)
-SubClassOf(obo:CL_0000129 obo:PR_000050567)
SubClassOf(obo:CL_0000129 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001012))
SubClassOf(obo:CL_0000129 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001813))
SubClassOf(obo:CL_0000129 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002064))
@@ -6318,7 +6461,13 @@ SubClassOf(obo:CL_0000130 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_3331
# Class: obo:CL_0000131 (gut endothelial cell)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri2171") Annotation(oboInOwl:hasDbXref "DOI:10.1111/bph.14527") Annotation(oboInOwl:hasDbXref "DOI:10.3390/ijms23073698") Annotation(oboInOwl:hasDbXref "DOI:10.3748/wjg.v17.i5.578") Annotation(oboInOwl:hasDbXref "DOI:full/10.15252/emmm.202114121") terms:description obo:CL_0000131 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Gut endothelial cells are a crucial component of the endothelium, a thin layer of single cells that line the interior surface of blood vessels and lymphatic vessels, including those in the digestive system or \"gut\". These cells plays an integral role in various physiological and metabolic functions, actively participating in nutrient absorption, host defense, and vascular homeostasis in the gut.
+The primary function of gut endothelial cells lies in their ability to control the passage of materials and the transit of white blood cells into and out of the bloodstream. They achieve this through the formation of a semi-permeable barrier, in which permeability is regulated by tight junctions; complex structures that bring the cells together, sealing the space between them. This ensures a controlled, selective passage of nutrients, ions, and water from the bloodstream into the gut and vice versa, helping maintain homeostasis and overall health.
+Gut endothelial cells also play a significant role in angiogenesis and serve as a critical regulator of the gut immune responses playing a modulative role in gut immune homeostasis and inflammatory responses. In addition, they generate nitric oxide, a potent vasodilator, which helps in maintaining vascular tonus, preventing platelet and leukocyte adhesion, and decreasing smooth muscle proliferation. These multi-faceted roles make gut endothelial cells indispensable for the normal functioning of the gut and overall health.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000131 "ZFA:0009078")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000131 "https://cellxgene.cziscience.com/cellguide/CL_0000131")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000131 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000131 "gut endothelial cell")
SubClassOf(obo:CL_0000131 obo:CL_0000115)
@@ -6524,12 +6673,17 @@ SubClassOf(obo:CL_0000147 obo:CL_0000325)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "SANBI:mhl") obo:IAO_0000115 obo:CL_0000148 "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000148 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/med.21754") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrc.2016.37") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1751-1097.2007.00226.x") Annotation(oboInOwl:hasDbXref "DOI:10.3390/ijms21249769") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/melanocyte") terms:description obo:CL_0000148 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Melanocytes are specialized cells prevalently found in the skin, but also present in the hair follicles, eyes, inner ear, bones, heart, and brain. Their primary function is the synthesis of melanin, a pigment responsible for coloration of skin, hair, and eyes. The presence and distribution of this pigment play a crucial role in the body's defense mechanism against harmful ultraviolet radiation.
+In addition to melanin production, melanocytes also engage in a variety of other biological functions. They play a fundamental role in the immune response, owing to their ability to present antigens to T cells. Furthermore, they contribute to the maintenance of the skin's homeostasis by regulating processes such as extracellular matrix remodeling and cytokine production. A balance in melanocyte function is pivotal, as dysfunctions often result in dermatological disorders. For instance, the loss of melanocytes or reduction in their function may lead to hypopigmentation conditions such as vitiligo, whereas an abnormal increase could result in hyperpigmentation disorders or melanoma, a dangerous type of skin cancer.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000148 "BTO:0000847")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000148 "CALOHA:TS-0613")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000148 "FMA:70545")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000148 "MESH:D008544")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000148 "VHOG:0001679")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000148 "ZFA:0009091")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000148 "https://cellxgene.cziscience.com/cellguide/CL_0000148")
AnnotationAssertion(oboInOwl:hasNarrowSynonym obo:CL_0000148 "melanophore")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000148 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000148 cl:general_cell_types_upper_slim)
@@ -6548,16 +6702,17 @@ AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_0000149 "pigment cell")
AnnotationAssertion(rdfs:label obo:CL_0000149 "visual pigment cell")
SubClassOf(obo:CL_0000149 obo:CL_0000147)
-# Class: obo:CL_0000150 (glandular epithelial cell)
+# Class: obo:CL_0000150 (glandular secretory epithelial cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0000150 "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ORCID:0000-0002-7073-9172") obo:IAO_0000115 obo:CL_0000150 "An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000150 "CALOHA:TS-2085")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000150 "FMA:86494")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000150 "glandular epithelial cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000150 cl:cellxgene_subset)
-AnnotationAssertion(rdfs:label obo:CL_0000150 "glandular epithelial cell")
-SubClassOf(obo:CL_0000150 obo:CL_0000066)
-SubClassOf(obo:CL_0000150 obo:CL_0000151)
-SubClassOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0006799))
+AnnotationAssertion(rdfs:label obo:CL_0000150 "glandular secretory epithelial cell")
+EquivalentClasses(obo:CL_0000150 ObjectIntersectionOf(obo:CL_0000066 obo:CL_0000151 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002530)))
+SubClassOf(obo:CL_0000150 obo:CL_1100001)
+SubClassOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002530))
# Class: obo:CL_0000151 (secretory cell)
@@ -6602,16 +6757,18 @@ SubClassOf(obo:CL_0000154 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0009306))
# Class: obo:CL_0000155 (peptic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0000155 "A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:21907708") Annotation(oboInOwl:hasDbXref "PMID:30571046") Annotation(oboInOwl:hasDbXref "Wikipedia:Gastric_chief_cell") obo:IAO_0000115 obo:CL_0000155 "An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by a basally located nucleus, abundant rough endoplasmic reticulum, and large apical secretory granules. It produces and secretes pepsinogen, the inactive precursor of the digestive enzyme pepsin.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000155 "FMA:62902")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000155 "chief cell of stomach")
-AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000155 "gastric chief cell")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "Wikipedia:Chief_cell") oboInOwl:hasExactSynonym obo:CL_0000155 "gastric chief cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000155 "pepsinogen secreting cell")
-AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000155 "zymogenic cell")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "Wikipedia:Chief_cell") oboInOwl:hasExactSynonym obo:CL_0000155 "zymogenic cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000155 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000155 "peptic cell")
+SubClassOf(obo:CL_0000155 obo:CL_0000152)
SubClassOf(obo:CL_0000155 obo:CL_0000154)
SubClassOf(obo:CL_0000155 obo:CL_0002659)
+SubClassOf(obo:CL_0000155 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0010038))
# Class: obo:CL_0000156 (obsolete antibody secreting cell)
@@ -6641,6 +6798,7 @@ AnnotationAssertion(rdfs:label obo:CL_0000158 "club cell")
SubClassOf(obo:CL_0000158 obo:CL_0000157)
SubClassOf(obo:CL_0000158 obo:CL_0002202)
SubClassOf(obo:CL_0000158 obo:CL_0011026)
+SubClassOf(obo:CL_0000158 obo:CL_1100001)
SubClassOf(obo:CL_0000158 ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0005902))
# Class: obo:CL_0000159 (seromucus secreting cell)
@@ -6651,7 +6809,7 @@ SubClassOf(obo:CL_0000159 obo:CL_0000151)
# Class: obo:CL_0000160 (goblet cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MESH:D020397") Annotation(oboInOwl:hasDbXref "http://en.wikipedia.org/wiki/Goblet_cell") obo:IAO_0000115 obo:CL_0000160 "A specialized, columnar, mucus secreting epithelial cell shaped like a flask or goblet. A narrow basal end contains the nucleus while the apical end is swollen by the accumulation of mucus laden secretory granules. Short microvilli project from the apical plasma membrane.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/S1357-2725(02)00083-3") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-022-00675-x") Annotation(oboInOwl:hasDbXref "DOI:10.1165/ajrcmb.25.5.f218") Annotation(oboInOwl:hasDbXref "DOI:10.1242/bio.20121701") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK553208/") terms:description obo:CL_0000160 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/S1357-2725(02)00083-3") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-022-00675-x") Annotation(oboInOwl:hasDbXref "DOI:10.1165/ajrcmb.25.5.f218") Annotation(oboInOwl:hasDbXref "DOI:10.1242/bio.20121701") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK553208/") terms:description obo:CL_0000160 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Goblet cells are specialized, simple columnar, secretory epithelial cells that are mostly found in the respiratory and intestinal tracts. The term \"goblet\" refers to their shape, which resembles a flask or goblet, specially at their apical end which is swollen due to the accumulation of secretory granules.
The primary function of goblet cells is to to protect and lubricate the underlying tissues by secreting large quantities of mucin, a complex glycoprotein, which forms mucus when hydrated. In the respiratory tract, the mucus secreted by these cells traps dust, bacteria, viruses, and other potentially harmful particles in the inhaled air, preventing them from reaching the delicate tissues of the lungs. In the intestines, the goblet cells secrete mucus that acts as a protective barrier shielding the intestinal epithelium from dietary antigens, pathogens and prevents the intestinal epithelium from being eroded by the actions of the digestive enzymes and the abrasive action of passing food material.
@@ -6665,10 +6823,10 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000160 "chalice cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000160 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000160 "goblet cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref ) Annotation(oboInOwl:hasDbXref ) foaf:depiction obo:CL_0000160 "https://upload.wikimedia.org/wikipedia/commons/thumb/c/c4/404_Goblet_Cell_new.jpg/800px-404_Goblet_Cell_new.jpg")
-SubClassOf(obo:CL_0000160 obo:CL_0000066)
+SubClassOf(obo:CL_0000160 obo:CL_0000319)
+SubClassOf(obo:CL_0000160 obo:CL_1100001)
SubClassOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005902))
SubClassOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0098594))
-SubClassOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0070254))
# Class: obo:CL_0000161 (obsolete acid secreting cell)
@@ -6679,14 +6837,19 @@ AnnotationAssertion(owl:deprecated obo:CL_0000161 "true"^^xsd:boolean)
# Class: obo:CL_0000162 (parietal cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") obo:IAO_0000115 obo:CL_0000162 "A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") Annotation(oboInOwl:hasDbXref "PMID:31613538") Annotation(oboInOwl:hasDbXref "PMID:31670611") obo:IAO_0000115 obo:CL_0000162 "An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by its pyramidal shape, abundant mitochondria, and a complex network of secretory canaliculi lined with microvilli. It secretes hydrochloric acid into the stomach lumen and produces intrinsic factor, essential for vitamin B12 absorption.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000162 "BTO:0001780")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000162 "FMA:62901")
-AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000162 "oxyntic cell")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:29263912") oboInOwl:hasExactSynonym obo:CL_0000162 "gastric parietal cell")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "Wikipedia:Parietal_cell") oboInOwl:hasExactSynonym obo:CL_0000162 "oxyntic cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000162 cl:cellxgene_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:29263912") Annotation(oboInOwl:hasDbXref "PMID:31613538") rdfs:comment obo:CL_0000162 "Parietal cells have dynamic, actin-supported microvilli that increase in number during active secretion, playing a crucial role in secreting hydrochloric acid and intrinsic factor. The structure and regulation of these microvilli are influenced by proteins such as ASAP3, which modulates Arf6 activity and actin assembly, thereby controlling microvilli formation and parietal cell function.")
AnnotationAssertion(rdfs:label obo:CL_0000162 "parietal cell")
+SubClassOf(obo:CL_0000162 obo:CL_0000152)
SubClassOf(obo:CL_0000162 obo:CL_0002659)
-SubClassOf(obo:CL_0000162 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0046717))
+SubClassOf(obo:CL_0000162 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0010038))
+SubClassOf(obo:CL_0000162 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005902))
+SubClassOf(obo:CL_0000162 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0001696))
# Class: obo:CL_0000163 (endocrine cell)
@@ -6708,7 +6871,7 @@ SubClassOf(obo:CL_0000163 ObjectSomeValuesFrom(obo:RO_0002215 ObjectIntersection
# Class: obo:CL_0000164 (enteroendocrine cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "SANBI:mhl") obo:IAO_0000115 obo:CL_0000164 "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41574-019-0168-8") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1463-1326.2011.01438.x") Annotation(oboInOwl:hasDbXref "DOI:10.1196/annals.1294.001") Annotation(oboInOwl:hasDbXref "DOI:10.1210/endrev/bnaa018") Annotation(oboInOwl:hasDbXref "DOI:10.7554/elife.78512") terms:description obo:CL_0000164 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41574-019-0168-8") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1463-1326.2011.01438.x") Annotation(oboInOwl:hasDbXref "DOI:10.1196/annals.1294.001") Annotation(oboInOwl:hasDbXref "DOI:10.1210/endrev/bnaa018") Annotation(oboInOwl:hasDbXref "DOI:10.7554/elife.78512") terms:description obo:CL_0000164 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Enteroendocrine cells are a specialized subset of cells located within the epithelial lining of both the small and large intestines, as well as the stomach and pancreas. Constituting less than 1% of the total population of intestinal cells, they are differentiated from a common intestinal cell progenitor, thus sharing lineage with absorptive and goblet cells of the intestines.
The distinct characteristic feature of an enteroendocrine cell is its inherent capacity to synthesize and secrete a plethora of gut hormones such as serotonin, somatostatin, neurotensin, cholecystokinin, secretin, gastric inhibitory peptide, motilin, and glucagon-like peptide-1. Integrated within this complex network of signaling agents, these substances control various aspects of the digestive system. Each enteroendocrine cell has its unique combination of hormones to release, determined by its position along the intestinal tract. Intriguingly, these hormones not only modulate local gut function, including motility, absorption and secretion, but also potentiate distant actions on other systems such as endocrine, nervous and immune and play a role in the feeling of satiety.
@@ -6720,8 +6883,8 @@ AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000188 "ZFA:0009115")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000188 "https://cellxgene.cziscience.com/cellguide/CL_0000188")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000188 "skeletal muscle cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000188 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000188 cl:general_cell_types_upper_slim)
@@ -7074,7 +7244,13 @@ SubClassOf(obo:CL_0000188 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000113
# Class: obo:CL_0000189 (slow muscle cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0323052908") obo:IAO_0000115 obo:CL_0000189 "A muscle cell that develops tension more slowly than a fast-twitch fiber.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1093/ptj/81.11.1810") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s13578-015-0054-6") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2021.747214") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/slow-muscle-fiber") terms:description obo:CL_0000189 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Slow muscle cells, as the name implies, are a type of muscle cell well known for their slow contractile speed. They are also referred to as type I, slow-twitch, or red muscles because of their high myoglobin content which gives them a dark, reddish appearance. These cells are predominantly found in the postural muscles of the body, such as those in the back and lower limbs.
+A defining characteristic of slow muscle cells is their significant resistance to fatigue. This is largely due to their efficient oxidative metabolism, which allows them to continuously contract over extended periods without succumbing to fatigue. This extraordinary endurance is facilitated by a high concentration of mitochondria, which enables the efficient use of oxygen for energy production, and capillaries, which supplies the necessary oxygen and nutrients. Additionally, these cells have an abundant supply of myoglobin, a protein that stores and transports oxygen within the muscle cell, further supporting their aerobic metabolism.
+The primary role of slow muscle cells in the human body is to provide sustained, low-intensity contractions over a prolonged period. They are responsible for maintaining posture and providing stability, rather than delivering short, powerful bursts of activity. They play a pivotal role in supporting various physical activities such as standing, walking, or any form of exercise that requires endurance over speed.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000189 "ZFA:0009116")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000189 "https://cellxgene.cziscience.com/cellguide/CL_0000189")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "ISBN:0815316208") oboInOwl:hasRelatedSynonym obo:CL_0000189 "slow muscle fiber")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000189 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000189 "slow muscle cell")
@@ -7084,7 +7260,13 @@ SubClassOf(obo:CL_0000189 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000857))
# Class: obo:CL_0000190 (fast muscle cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0323052908") obo:IAO_0000115 obo:CL_0000190 "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1152/japplphysiol.00636.2019") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fcell.2018.00125") Annotation(oboInOwl:hasDbXref "DOI:10.4161/org.4.3.6312") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/fast-muscle-fiber") terms:description obo:CL_0000190 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Fast muscle cells, also known as type II muscle fibers, are a particular type of muscle cell that specializes in conducting rapid, high-intensity contractions. These cells are primarily found within skeletal muscle groups that are directly involved in gross motor activities, such as running, jumping, or lifting heavy weights. The designation \"fast\" refers to their speed of contraction in response to neural stimuli, which is significantly quicker when compared to other muscle cell types such as slow-twitch or type I muscle fibers.
+The primary function of fast muscle cells revolves around their role in anaerobic metabolism, which provides the energy needed for short, forceful bursts of power. They contain a high concentration of glycolytic enzymes that facilitate this process, leading to a swift break down of glucose to generate ATP (adenosine triphosphate), the primary energy currency in biological systems. On the downside, the byproduct of this very rapid, anaerobic metabolic process is lactic acid, which can build up and cause muscle fatigue.
+Fast muscle cells can be further classified into two subtypes based on their metabolic characteristics: type IIa and type IIb/x. Type IIa cells, also known as fast oxidative-glycolytic fibers, possess a good oxygen supply and can function in both anaerobic and aerobic conditions, exhibiting moderate resistance to fatigue. On the other hand, type IIb/x cells, also known as fast glycolytic fibers, primarily rely on anaerobic metabolism and tire out a lot quicker. Both these subtypes can adapt to changing demands due to exercise and conditioning, highlighting the plasticity that is a key characteristic of these versatile muscle cells.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000190 "ZFA:0009117")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000190 "https://cellxgene.cziscience.com/cellguide/CL_0000190")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000190 "glycolytic muscle fiber")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000190 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000190 "fast muscle cell")
@@ -7101,11 +7283,17 @@ AnnotationAssertion(owl:deprecated obo:CL_0000191 "true"^^xsd:boolean)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MESH:D032389") Annotation(oboInOwl:hasDbXref "PMID:9315361") Annotation(oboInOwl:hasDbXref "http://en.wikipedia.org/wiki/Smooth_muscle_cell") obo:IAO_0000115 obo:CL_0000192 "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast).")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000192 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1093/ptj/81.11.1810") Annotation(oboInOwl:hasDbXref "https://training.seer.cancer.gov/anatomy/muscular/types.html") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK10854/") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK526125") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK556137/") terms:description obo:CL_0000192 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Smooth muscle cells are a specialized type of muscle cells that are primarily found within the walls of hollow organs such as the intestine, stomach, bladder, uterus, and blood vessels. These cells are an essential component of the autonomic nervous system controling involuntary movements within the body.
+Smooth muscle cells play a vital role in many physiological processes due to their unique functionality. They can contract and relax in a slow, sustained, and controlled manner to help modulate the size and shape of the lumens of the organs they surround. For example, in the digestive system, coordinated contraction and relaxation of smooth muscle cells propels food along the gastrointestinal tract - a process known as peristalsis. In the blood vessels, the smooth muscle cells, by contracting or relaxing, either constrict or dilate the vessels, which in turn, help regulate blood flow and pressure.
+On a cellular level, smooth muscle cells possess a single, centrally located nucleus and contain an arranged network of actin and myosin filaments, which are the proteins responsible for muscle contraction. Unlike their counterparts in skeletal or cardiac muscles, these cells lack specific contact points for these filaments, hence the lack of visible striations. Furthermore, the contraction of smooth muscle cells is regulated by hormones and neurotransmitters, such as acetylcholine and norepinephrine, adding an additional layer of complex regulation to these highly specialized cells.")
AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_0000192 "non-striated muscle cell")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000192 "BTO:0004576")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000192 "CALOHA:TS-2159")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000192 "FMA:14072")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000192 "ZFA:0009118")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000192 "https://cellxgene.cziscience.com/cellguide/CL_0000192")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:9315361") oboInOwl:hasExactSynonym obo:CL_0000192 "SMCs")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MESH:D032389") oboInOwl:hasExactSynonym obo:CL_0000192 "myocytes, smooth muscle")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000192 "smooth muscle fiber")
@@ -7242,6 +7430,7 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000207 "Schultze's cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000207 "odorant receptor cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000207 "olfactory receptor neuron")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000207 "olfactory sensory neuron")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000207 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000207 "olfactory receptor cell")
EquivalentClasses(obo:CL_0000207 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050911)))
SubClassOf(obo:CL_0000207 obo:CL_0000006)
@@ -7296,6 +7485,7 @@ SubClassOf(obo:CL_0000211 obo:CL_0000000)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CL:CVS") obo:IAO_0000115 obo:CL_0000212 "A cell that takes up and metabolizes substances.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000212 obo:NCBITaxon_9606)
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000212 "ZFA:0009129")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000212 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000212 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0000212 "absorptive cell")
SubClassOf(obo:CL_0000212 obo:CL_0000000)
@@ -7340,6 +7530,7 @@ EquivalentClasses(obo:CL_0000216 ObjectIntersectionOf(obo:CL_0000630 ObjectSomeV
SubClassOf(obo:CL_0000216 obo:CL_0000511)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000216 obo:CL_0000630)
SubClassOf(obo:CL_0000216 obo:CL_0002625)
+SubClassOf(obo:CL_0000216 obo:CL_1100001)
# Class: obo:CL_0000217 (insulating cell)
@@ -7356,6 +7547,7 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000218 "CALOHA:TS-0898")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000218 "FMA:62121")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000218 "ZFA:0009135")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000218 "neurilemmal cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000218 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000218 "myelinating Schwann cell")
SubClassOf(obo:CL_0000218 obo:CL_0000217)
SubClassOf(obo:CL_0000218 obo:CL_0002573)
@@ -7386,6 +7578,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MESH:D004475") obo:IAO_000011
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000221 "FMA:72549")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000221 "ZFA:0009137")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000221 "ectoderm cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000221 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000221 "ectodermal cell")
SubClassOf(obo:CL_0000221 obo:CL_0000255)
SubClassOf(obo:CL_0000221 obo:CL_0002321)
@@ -7394,8 +7587,13 @@ SubClassOf(obo:CL_0000221 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000092
# Class: obo:CL_0000222 (mesodermal cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MESH:D008648") obo:IAO_0000115 obo:CL_0000222 "A cell of the middle germ layer of the embryo.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.ceb.2019.07.012") Annotation(oboInOwl:hasDbXref "DOI:10.5535/arm.2016.40.1.162") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/mesoderm") terms:description obo:CL_0000222 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Mesodermal cells are pluripotent and the most abundant in the human body. They contribute to the development of several structures such as the skeletal muscles, bones, heart and blood vessels, kidneys, gonads, connective tissues, and certain layers of the skin. Hence, the mesoderm is often regarded as an active and diverse layer due to its role in forming many bodily structures.
+In embryonic development, these cells are instrumental, contributing to the body's structures through a carefully coordinated sequence of morphogenetic movements. This process forms the complex multicellular architecture of tissues and organs from a simple ball of cells. Without the function of mesodermal cells, the body's integral structures and systems would cease to form correctly, leading to developmental disorders such as axial mesodermal dysplasia complex")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000222 "FMA:72554")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000222 "ZFA:0009138")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000222 "https://cellxgene.cziscience.com/cellguide/CL_0000222")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000222 "mesoblast")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000222 "mesoderm cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000222 cl:cellxgene_subset)
@@ -7537,7 +7735,6 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000234 "BTO:0001044")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000234 "FMA:83806")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000234 "MESH:D010586")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000234 "ZFA:0009140")
-AnnotationAssertion(oboInOwl:inSubset obo:CL_0000234 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000234 "phagocyte")
EquivalentClasses(obo:CL_0000234 ObjectIntersectionOf(obo:CL_0000000 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0006909)))
SubClassOf(obo:CL_0000234 obo:CL_0000219)
@@ -7697,9 +7894,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "VHOG:0001484") oboInOwl:hasEx
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000247 "Rohon-Beard cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "VHOG:0001484") oboInOwl:hasRelatedSynonym obo:CL_0000247 "RB neuron")
AnnotationAssertion(rdfs:label obo:CL_0000247 "Rohon-Beard neuron")
-SubClassOf(obo:CL_0000247 obo:CL_0000006)
SubClassOf(obo:CL_0000247 obo:CL_0000531)
-SubClassOf(obo:CL_0000247 obo:CL_4023168)
# Class: obo:CL_0000248 (obsolete microsporocyte)
@@ -7755,7 +7950,6 @@ AnnotationAssertion(owl:deprecated obo:CL_0000254 "true"^^xsd:boolean)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_0000255 "Any cell that in taxon some Eukaryota.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000255 "MESH:D005057")
-AnnotationAssertion(oboInOwl:inSubset obo:CL_0000255 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000255 "eukaryotic cell")
EquivalentClasses(obo:CL_0000255 ObjectIntersectionOf(obo:CL_0000000 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_2759)))
SubClassOf(obo:CL_0000255 obo:CL_0000000)
@@ -8069,10 +8263,16 @@ AnnotationAssertion(owl:deprecated obo:CL_0000299 "true"^^xsd:boolean)
# Class: obo:CL_0000300 (gamete)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0721662544") obo:IAO_0000115 obo:CL_0000300 "A mature sexual reproductive cell having a single set of unpaired chromosomes.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41586-020-2347-0") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fcell.2022.1040708") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK10008/") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK553142/") terms:description obo:CL_0000300 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Gametes are reproductive cells essential for sexual reproduction in eukaryotic organisms, including humans, animals, and many plants. These cells are haploid, containing half the genome or only one set of chromosomes, which is a contrast to the diploid state (two sets of chromosomes) found in most cells in a multicellular organism. This reduction in genetic material is crucial since it allows for the re-establishment of the diploid number of chromosomes when two gametes merge to form a diploid zygote during fertilization.
+There are two major types of gametes in animals: sperm cells in males and egg (or ova) in females. These gametes contribute equally to the genetic makeup of the offspring but are morphologically and functionally distinct. Sperm cells (or spermatozoa) are characterized by their motility, small size, and large quantities; they are produced continuously in vast numbers through a process called spermatogenesis in the male gonads or testes. Female gametes are much larger, fewer in numbers, and are not motile; they undergo a development process known as oogenesis, which takes place within the ovaries. The egg also contributes most of the cytoplasm and organelles (including mitochondria) to the zygote that are required for initial cell division stages after fertilization.
+Gametes have a primary role in sexual reproduction and genetic variation, which aids in evolution. The formation of gametes involves a special type of cell division called meiosis that introduces genetic diversity via the process of recombination and independent assortment. Following the fusion of male and female gametes, the combination of paternal and maternal genetic material in the zygote allows for genetic recombination, which is a fundamental source of genetic variation and, thus, evolution. Therefore, gametes not only are critical to the inception of new individuals but also contribute to species survival and evolution.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000300 "CALOHA:TS-0395")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000300 "FBbt:00005412")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000300 "FMA:18649")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000300 "ZFA:0009156")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000300 "https://cellxgene.cziscience.com/cellguide/CL_0000300")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000300 "haploid nucleated cell")
AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_0000300 "haploid germ cell")
AnnotationAssertion(rdfs:label obo:CL_0000300 "gamete")
@@ -8209,15 +8409,19 @@ AnnotationAssertion(obo:IAO_0100001 obo:CL_0000316 obo:PO_0000082)
AnnotationAssertion(rdfs:label obo:CL_0000316 "obsolete ray initial")
AnnotationAssertion(owl:deprecated obo:CL_0000316 "true"^^xsd:boolean)
-# Class: obo:CL_0000317 (sebum secreting cell)
+# Class: obo:CL_0000317 (sebocyte)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MESH:D012629") obo:IAO_0000115 obo:CL_0000317 "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MESH:D012629") Annotation(oboInOwl:hasDbXref "PMID:19944183") obo:IAO_0000115 obo:CL_0000317 "An epithelial cell that is part of a sebaceous gland. This cell produces and secretes sebum, an oily, lipid-rich substance, through holocrine secretion where the entire cell ruptures to release its contents.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000317 obo:NCBITaxon_9606)
-AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000317 "sebocyte")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000317 "sebum secreting cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000317 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000317 core:human_reference_atlas)
-AnnotationAssertion(rdfs:label obo:CL_0000317 "sebum secreting cell")
-EquivalentClasses(obo:CL_0000317 ObjectIntersectionOf(obo:CL_0000151 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001821)))
+AnnotationAssertion(rdfs:label obo:CL_0000317 "sebocyte")
+EquivalentClasses(obo:CL_0000317 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001821)))
+SubClassOf(obo:CL_0000317 obo:CL_0000150)
SubClassOf(obo:CL_0000317 obo:CL_0000152)
+SubClassOf(obo:CL_0000317 obo:CL_0000362)
+SubClassOf(obo:CL_0000317 obo:CL_0002308)
SubClassOf(obo:CL_0000317 obo:CL_2000021)
# Class: obo:CL_0000318 (sweat secreting cell)
@@ -8228,13 +8432,13 @@ SubClassOf(obo:CL_0000318 obo:CL_0000150)
# Class: obo:CL_0000319 (mucus secreting cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_0000319 "Any secretory cell that is capable of some mucus secretion.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_0000319 "Any cell that is capable of some mucus secretion.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000319 "BTO:0003689")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000319 "ZFA:0009159")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000319 "mucous cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000319 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000319 "mucus secreting cell")
-EquivalentClasses(obo:CL_0000319 ObjectIntersectionOf(obo:CL_0000151 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0070254)))
+EquivalentClasses(obo:CL_0000319 ObjectIntersectionOf(obo:CL_0000000 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0070254)))
SubClassOf(obo:CL_0000319 obo:CL_0000159)
SubClassOf(obo:CL_0000319 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0070254))
@@ -8283,6 +8487,7 @@ SubClassOf(obo:CL_0000323 obo:CL_0000154)
# Class: obo:CL_0000324 (metanephric mesenchyme stem cell)
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000324 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000324 "metanephric mesenchyme stem cell")
SubClassOf(obo:CL_0000324 obo:BFO_0000002)
SubClassOf(obo:CL_0000324 obo:CL_0000134)
@@ -8501,6 +8706,7 @@ SubClassOf(obo:CL_0000348 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000008))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_0000349 "Any cell that is part of some extraembryonic structure.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000349 "ZFA:0009176")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000349 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000349 cl:general_cell_types_upper_slim)
AnnotationAssertion(rdfs:label obo:CL_0000349 "extraembryonic cell")
EquivalentClasses(obo:CL_0000349 ObjectIntersectionOf(obo:CL_0000000 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000478)))
@@ -8518,7 +8724,13 @@ SubClassOf(obo:CL_0000350 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_001030
# Class: obo:CL_0000351 (trophoblast cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "MESH:D014327") Annotation(oboInOwl:hasDbXref "PMID:37630754") Annotation(oboInOwl:hasDbXref "doi:10.1007/978-3-030-84725-8") obo:IAO_0000115 obo:CL_0000351 "An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.jri.2023.103811") Annotation(oboInOwl:hasDbXref "DOI:10.1530/JOE-17-0402") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK53245") terms:description obo:CL_0000351 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Trophoblast cells, originating from the blastocyst's outer layer, are highly specialized and pivotal for embryo development. Their crucial roles include facilitating implantation and contributing to the formation of the placenta, an essential organ for fetal nutrition, gas exchange, and waste removal during pregnancy.
+These cells play a crucial role in implantation by adhering to the uterus lining. Post-implantation, some trophoblast cells differentiate, forming syncytiotrophoblasts. These multi-nucleated cells absorb nutrients, release waste, and secrete hormones, including human chorionic gonadotropin (hCG), sustaining pregnancy.
+Trophoblast cells also play a crucial role in immune tolerance, preventing the maternal immune system from treating the fetus as foreign. This balance is vital for a healthy pregnancy. Dysfunctional trophoblast cells may lead to complications like miscarriages or preeclampsia, emphasizing their importance in both embryology and reproductive medicine.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000351 "FMA:83028")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000351 "https://cellxgene.cziscience.com/cellguide/CL_0000351")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1007/978-3-030-84725-8") oboInOwl:hasExactSynonym obo:CL_0000351 "trophoblastic cell")
AnnotationAssertion(rdfs:label obo:CL_0000351 "trophoblast cell")
SubClassOf(obo:CL_0000351 obo:BFO_0000002)
@@ -8574,6 +8786,11 @@ SubClassOf(obo:CL_0000357 obo:CL_0000036)
# Class: obo:CL_0000358 (sphincter associated smooth muscle cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:cjm") obo:IAO_0000115 obo:CL_0000358 "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK482438/") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK532857/") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK557452/") terms:description obo:CL_0000358 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Smooth muscle cells, as a broader category, are non-striated, involuntary muscle cells that usually exhibit contractions and dilation to facilitate numerous physiological functions. Sphincter associated smooth muscle cells are a specific type of smooth muscle cell that are primarily associated with the functioning of various anatomical sphincters in the human body.
+The traits that distinguishes sphincter associated smooth muscle cells from other smooth muscle cells are their location and specialized function in sphincter mechanisms. Sphincter associated smooth muscle cells play a pivotal role in regulating the opening and closure of the bodily sphincters. These sphincters can be found at multiple locations within the body including the gastrointestinal tract (namely the esophagus, stomach, small intestine, and rectum), the urinary tract, and the circulatory system. Upon receiving signals from the autonomous nervous system, these cells contract or relax to modulate the aperture of sphincters, thus controlling the movement of substances through them. Due to their precise and vital functional role, any dysfunction or dysregulation in these cells can lead to serious medical conditions, such as gastroesophageal reflux or urinary incontinence.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000358 "https://cellxgene.cziscience.com/cellguide/CL_0000358")
AnnotationAssertion(rdfs:label obo:CL_0000358 "sphincter associated smooth muscle cell")
EquivalentClasses(obo:CL_0000358 ObjectIntersectionOf(obo:CL_0000192 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004590)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000358 obo:CL_0000192)
@@ -8583,7 +8800,13 @@ SubClassOf(obo:CL_0000358 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000459
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:dsd") Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0000359 "A smooth muscle cell associated with the vasculature.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000359 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1093/cvr/cvs135") Annotation(oboInOwl:hasDbXref "DOI:10.1093/cvr/cvy023") Annotation(oboInOwl:hasDbXref "DOI:10.1161/ATVBAHA.118.311229") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2020.599415") Annotation(oboInOwl:hasDbXref "DOI:10.3390/ijms20225694") terms:description obo:CL_0000359 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Vascular associated smooth muscle cells (VSMCs) are specialized cells that constitute a major component of the blood vessel wall in the circulatory system. They derive their name from the predominantly smooth appearance under microscopic examination, as opposed to the striated appearance of cardiac and skeletal muscles.
+A principal function of VSMCs is to regulate vascular tone, which directly dictates blood pressure and blood flow distribution across various body parts. This is achieved through coordinated contraction and relaxation of the muscles in response to a variety of extracellular signals. When a blood vessel is exposed to stimuli like pressure or injury, VSMCs contract, resulting in vasoconstriction and ultimately, an increase in blood pressure. Conversely, in response to vasodilators, these cells relax, leading to vasodilation and a consequent decrease in blood pressure.
+VSMCs are also involved in vascular remodeling, a process where blood vessels adapt their structure to long-term changes in hemodynamic conditions or disease states. In diseases like atherosclerosis and hypertension, an aberrant proliferative and synthetic phenotype of VSMCs contributes to the formation of plaques, leading to vessel hardening or even occlusion. Recent research has further implicated these cells in immune responses, recognizing their function in leukocyte recruitment and inflammation, factors that are largely instrumental in vascular pathologies.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000359 "ZFA:0009181")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000359 "https://cellxgene.cziscience.com/cellguide/CL_0000359")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000359 "VSMC")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000359 "vascular smooth muscle cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000359 cl:cellxgene_subset)
@@ -8750,7 +8973,8 @@ SubClassOf(obo:CL_0000378 obo:CL_0000630)
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000379 "ZFA:0009185")
AnnotationAssertion(rdfs:label obo:CL_0000379 "sensory processing neuron")
-SubClassOf(obo:CL_0000379 obo:CL_0000540)
+SubClassOf(obo:CL_0000379 obo:CL_2000029)
+SubClassOf(obo:CL_0000379 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050893))
# Class: obo:CL_0000380 (thecogen cell)
@@ -8925,17 +9149,17 @@ AnnotationAssertion(rdfs:comment obo:CL_0000401 "Obsoleted as plasmatocytes are
AnnotationAssertion(rdfs:label obo:CL_0000401 "obsolete macrophage (sensu Diptera)")
AnnotationAssertion(owl:deprecated obo:CL_0000401 "true"^^xsd:boolean)
-# Class: obo:CL_0000402 (CNS interneuron)
+# Class: obo:CL_0000402 (obsolete CNS interneuron)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/B978-0-12-817424-1.00001-X") obo:IAO_0000115 obo:CL_0000402 "An interneuron that has its cell body in a central nervous system.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/B978-0-12-817424-1.00001-X") obo:IAO_0000115 obo:CL_0000402 "OBSOLETE. An interneuron that has its cell body in a central nervous system.")
+AnnotationAssertion(obo:IAO_0000233 obo:CL_0000402 )
+AnnotationAssertion(obo:IAO_0100001 obo:CL_0000402 obo:CL_0000099)
AnnotationAssertion(obo:RO_0002175 obo:CL_0000402 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000402 "ZFA:0009191")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000402 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000402 core:human_reference_atlas)
AnnotationAssertion(rdfs:comment obo:CL_0000402 "Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system.")
-AnnotationAssertion(rdfs:label obo:CL_0000402 "CNS interneuron")
-EquivalentClasses(obo:CL_0000402 ObjectIntersectionOf(obo:CL_0000099 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0001017)))
-SubClassOf(obo:CL_0000402 obo:CL_0000099)
-SubClassOf(obo:CL_0000402 obo:CL_2000029)
+AnnotationAssertion(rdfs:label obo:CL_0000402 "obsolete CNS interneuron")
+AnnotationAssertion(owl:deprecated obo:CL_0000402 "true"^^xsd:boolean)
# Class: obo:CL_0000403 (obo:CL_0000403)
@@ -8961,7 +9185,7 @@ AnnotationAssertion(owl:deprecated obo:CL_0000405 "true"^^xsd:boolean)
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000406 "ZFA:0009194")
AnnotationAssertion(rdfs:label obo:CL_0000406 "CNS short range interneuron")
-SubClassOf(obo:CL_0000406 obo:CL_0000402)
+SubClassOf(obo:CL_0000406 obo:CL_0000099)
# Class: obo:CL_0000407 (scolopidial ligament cell)
@@ -8975,8 +9199,14 @@ SubClassOf(obo:CL_0000407 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000103
# Class: obo:CL_0000408 (male gamete)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_0000408 "Any male germ cell that has characteristic some haploid and is capable of some fertilization.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.semcdb.2016.04.009") Annotation(oboInOwl:hasDbXref "DOI:10.1242/dev.202046") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK26843/") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK553142/") terms:description obo:CL_0000408 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+The male gamete, also known as a sperm cell, is a highly specialized cell type critical to sexual reproduction. Sperm are produced during a process called spermatogenesis within the male reproductive organ, specifically the testes. They are haploid cells, carrying the genetic material from the male parent, and fuse with the ovum, the female gamete, to form a diploid zygote during fertilization, thereby initiating gestation and the development of a new organism.
+The male gamete is distinguished by its morphology, notably its elongated shape which is geared towards locomotion. One of the primary characteristics of a male gamete is its flagellum, or tail, which propels the cell towards the female gamete. It additionally contains an elongated head region housing the nucleus, where the genetic material is stored. The anterior section of the head, the acrosome, releases enzymes essential for penetrating the protective layers of the ovum during the fertilization process.
+The function of male gametes does not cease upon fertilization. In addition to delivering the paternal set of chromosomes, fusion of the sperm cell with the ovum causes an increase in cytosolic Ca2+ which then activates the female egg cell to undergo the so-called cortical reaction during which the egg’s zona pellucida is changed so fusion with additional sperm is prevented. The Ca2+ signal also initiates the development of the zygote and eventual formation of an embryo. Male gametes also contribute towards forming the placenta, which supplies nutrients and removes waste products during gestation.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000408 "BTO:0001277")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000408 "CALOHA:TS-0949")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000408 "https://cellxgene.cziscience.com/cellguide/CL_0000408")
AnnotationAssertion(rdfs:label obo:CL_0000408 "male gamete")
EquivalentClasses(obo:CL_0000408 ObjectIntersectionOf(obo:CL_0000015 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0001375) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0009566)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000408 obo:CL_0000015)
@@ -8993,7 +9223,7 @@ AnnotationAssertion(owl:deprecated obo:CL_0000409 "true"^^xsd:boolean)
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000410 "ZFA:0009195")
AnnotationAssertion(rdfs:label obo:CL_0000410 "CNS long range interneuron")
-SubClassOf(obo:CL_0000410 obo:CL_0000402)
+SubClassOf(obo:CL_0000410 obo:CL_0000099)
# Class: obo:CL_0000411 (Caenorhabditis hypodermal cell)
@@ -9099,7 +9329,7 @@ SubClassOf(obo:CL_0000423 obo:CL_0000422)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:19783135") obo:IAO_0000115 obo:CL_0000424 "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000424 "WBbt:0005812")
AnnotationAssertion(rdfs:label obo:CL_0000424 "excretory cell")
-SubClassOf(obo:CL_0000424 obo:CL_0000151)
+SubClassOf(obo:CL_0000424 obo:CL_0000000)
# Class: obo:CL_0000425 (pore cell)
@@ -9185,7 +9415,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "ISBN:0198547684") obo:IAO_000
AnnotationAssertion(obo:RO_0002175 obo:CL_0000434 obo:NCBITaxon_9606)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000434 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0000434 "eccrine cell")
-SubClassOf(obo:CL_0000434 obo:CL_0000150)
+SubClassOf(obo:CL_0000434 obo:CL_1100001)
# Class: obo:CL_0000435 (alkali secreting cell)
@@ -9304,8 +9534,9 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000446 "parathyroid gland c
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000446 "parathyroid hormone secreting cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000446 "principal cell of parathyroid gland")
AnnotationAssertion(rdfs:label obo:CL_0000446 "chief cell of parathyroid gland")
-SubClassOf(obo:CL_0000446 obo:CL_0000167)
-SubClassOf(obo:CL_0000446 obo:CL_0002260)
+SubClassOf(obo:CL_0000446 obo:CL_1001593)
+SubClassOf(obo:CL_0000446 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0011197))
+SubClassOf(obo:CL_0000446 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0035898))
# Class: obo:CL_0000447 (carbohydrate secreting cell)
@@ -9331,6 +9562,7 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000449 "CALOHA:TS-0099")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000449 "FMA:83435")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000449 "brown adipose cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000449 "brown fat cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000449 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000449 "brown adipocyte")
SubClassOf(obo:CL_0000449 obo:CL_0000136)
SubClassOf(obo:CL_0000449 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001348))
@@ -9360,7 +9592,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000451 "dendritic cell")
EquivalentClasses(obo:CL_0000451 ObjectIntersectionOf(obo:CL_0000738 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0042613) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001003) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0001407) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0001816) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002504) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0019882) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0045580)))
SubClassOf(obo:CL_0000451 obo:CL_0000113)
SubClassOf(obo:CL_0000451 obo:CL_0000145)
-SubClassOf(obo:CL_0000451 obo:PR_000050567)
SubClassOf(obo:CL_0000451 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0042613))
SubClassOf(obo:CL_0000451 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002))
SubClassOf(obo:CL_0000451 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001003))
@@ -9447,6 +9678,7 @@ AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000503 "ZFA:0009229")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000503 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000503 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0000503 "theca cell")
-SubClassOf(obo:CL_0000503 obo:CL_0000593)
SubClassOf(obo:CL_0000503 obo:CL_0002132)
-SubClassOf(obo:CL_0000503 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001305))
+SubClassOf(obo:CL_0000503 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000155))
# Class: obo:CL_0000504 (enterochromaffin-like cell)
@@ -9895,17 +10128,16 @@ SubClassOf(obo:CL_0000507 obo:CL_0000167)
# Class: obo:CL_0000508 (type G enteroendocrine cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") Annotation(oboInOwl:hasDbXref "MESH:D019863") obo:IAO_0000115 obo:CL_0000508 "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") Annotation(oboInOwl:hasDbXref "MESH:D019863") Annotation(oboInOwl:hasDbXref "PMID:10700044") Annotation(oboInOwl:hasDbXref "PMID:35674015") Annotation(oboInOwl:hasDbXref "PMID:37240181") obo:IAO_0000115 obo:CL_0000508 "An endocrine cell found in the stomach and duodenum and is responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000508 "BTO:0004108")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000508 "FMA:67609")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000508 "G cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000508 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000508 "type G enteroendocrine cell")
SubClassOf(obo:CL_0000508 obo:CL_0000164)
+SubClassOf(obo:CL_0000508 obo:CL_0000165)
SubClassOf(obo:CL_0000508 obo:CL_0000506)
SubClassOf(obo:CL_0000508 obo:CL_0000509)
-SubClassOf(obo:CL_0000508 obo:CL_0002659)
-SubClassOf(obo:CL_0000508 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004997))
# Class: obo:CL_0000509 (gastrin secreting cell)
@@ -9917,8 +10149,8 @@ SubClassOf(obo:CL_0000509 obo:CL_0000167)
# Class: obo:CL_0000510 (paneth cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") Annotation(oboInOwl:hasDbXref "MESH:D019879") Annotation(oboInOwl:hasDbXref "PMID:29184701") Annotation(oboInOwl:hasDbXref "PMID:32308658") obo:IAO_0000115 obo:CL_0000510 "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00018-002-8412-z") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nature09637") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrmicro2546") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-030212-183744") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2020.00587") terms:description obo:CL_0000510 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") Annotation(oboInOwl:hasDbXref "MESH:D019879") Annotation(oboInOwl:hasDbXref "PMID:29184701") Annotation(oboInOwl:hasDbXref "PMID:32308658") Annotation(oboInOwl:hasDbXref "PMID:33484640") obo:IAO_0000115 obo:CL_0000510 "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00018-002-8412-z") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nature09637") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrmicro2546") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-030212-183744") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2020.00587") terms:description obo:CL_0000510 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Paneth cells are specialized epithelial cells that are primarily located at the bottom of the crypts of Lieberkühn in the small intestine, where they play a pivotal role in maintaining gut homeostasis. They have also been found in smaller numbers in the colonic crypts and other parts of the gastrointestinal tract. Paneth cells are characterized by large acidophilic granules, which take up most of the cytoplasmic volume, causing the nucleus to be pushed toward the base of the cell.
Paneth cells function as a part of the innate immune system. The large granules inside the cells are filled with antimicrobial peptides, such as defensins and lysozymes. Upon bacterial intrusion or cellular signaling indicating a potential infection, Paneth cells release the granules containing the antimicrobial substances into the crypt lumen, effectively serving as the first line of defense against bacterial invasion within the gastrointestinal tract. In essence, Paneth cells serve as guardians, protecting the intestinal stem cells from harmful pathogens that may disturb the gut ecosystem.
@@ -9928,10 +10160,13 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000510 "FMA:62897")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000510 "https://cellxgene.cziscience.com/cellguide/CL_0000510")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000510 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000510 "paneth cell")
-SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000510 obo:CL_0000150)
+SubClassOf(obo:CL_0000510 obo:CL_0000150)
SubClassOf(obo:CL_0000510 obo:CL_0000323)
SubClassOf(obo:CL_0000510 obo:CL_0002563)
-SubClassOf(obo:CL_0000510 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001983))
+SubClassOf(obo:CL_0000510 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0011184))
+SubClassOf(obo:CL_0000510 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005773))
+SubClassOf(obo:CL_0000510 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005902))
+SubClassOf(obo:CL_0000510 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_4047017))
# Class: obo:CL_0000511 (androgen binding protein secreting cell)
@@ -9963,8 +10198,14 @@ SubClassOf(obo:CL_0000513 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000113
# Class: obo:CL_0000514 (smooth muscle myoblast)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "MESH:D032390") obo:IAO_0000115 obo:CL_0000514 "A precursor cell destined to differentiate into smooth muscle myocytes.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1074/jbc.RA118.001739") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK544225/") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/medicine-and-dentistry/smooth-muscle") terms:description obo:CL_0000514 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+A precursor to the smooth muscle cell, the smooth muscle myoblast, is integral to various body systems, including the cardiovascular, gastrointestinal, and respiratory systems. Smooth muscle myoblasts arise from the differentiation of mesenchymal stem cells, a process tightly regulated by specific genetic factors and environmental signals. Their role extends to myogenesis, particularly in the formation of muscular tissue, especially during embryonic development.
+Smooth muscle myoblasts possess distinctive cellular characteristics. In contrast to skeletal muscle myoblasts, they do not fuse to create multinucleated fibers. Instead, they differentiate into individual, uninucleated smooth muscle cells. This differentiation unfolds in two distinct phases: proliferation, marked by rapid division to increase cell numbers, and differentiation, involving structural and functional transformation into mature smooth muscle cells. This intricate process is intricately mediated by various signaling molecules and transcription factors.
+Functionally, smooth muscle myoblasts and the mature muscle cells they generate play pivotal roles in various physiological processes. Smooth muscle cells orchestrate involuntary muscle responses and are integral to body systems that regulate blood flow, propel food along the digestive tract, and control airflow in the respiratory tract. These diverse functions underscore the significance of smooth muscle myoblasts in the body's growth, maintenance, and overall function.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000514 "FMA:84798")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000514 "ZFA:0009235")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000514 "https://cellxgene.cziscience.com/cellguide/CL_0000514")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MESH:D032390") oboInOwl:hasExactSynonym obo:CL_0000514 "myoblast, smooth muscle")
AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_0000514 "satellite cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000514 cl:cellxgene_subset)
@@ -9995,6 +10236,7 @@ AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000527 "ZFA:0009239")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000527 "output neuron")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000527 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000527 "efferent neuron")
SubClassOf(obo:CL_0000527 obo:CL_0000540)
@@ -10120,7 +10363,8 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:1842357") Annotation(obo
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000530 "ZFA:0009242")
AnnotationAssertion(rdfs:label obo:CL_0000530 "primary neuron (sensu Teleostei)")
SubClassOf(obo:CL_0000530 obo:BFO_0000002)
-SubClassOf(obo:CL_0000530 obo:CL_0000540)
+SubClassOf(obo:CL_0000530 obo:CL_2000029)
+SubClassOf(obo:CL_0000530 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002240))
SubClassOf(Annotation(obo:IAO_0000233 "https://github.com/obophenotype/cell-ontology/pull/1950") obo:CL_0000530 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_32443))
# Class: obo:CL_0000531 (primary sensory neuron (sensu Teleostei))
@@ -10134,7 +10378,11 @@ SubClassOf(obo:CL_0000531 obo:CL_0000530)
# Class: obo:CL_0000532 (CAP motoneuron)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:17971221") Annotation(oboInOwl:hasDbXref "PMID:35431796") obo:IAO_0000115 obo:CL_0000532 "A primary motor neuron with its soma in the caudal region of a spinal cord. The axon of this motoneuron exit the spinal cord from one single point and innervates the lateral surface of ventral axial muscles")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000532 "ZFA:0009243")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:3746410") oboInOwl:hasExactSynonym obo:CL_0000532 "CaP motorneuron")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:17971221") oboInOwl:hasRelatedSynonym obo:CL_0000532 "cap cell")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18077593") oboInOwl:hasRelatedSynonym obo:CL_0000532 "caudal primary motor neuron")
AnnotationAssertion(rdfs:label obo:CL_0000532 "CAP motoneuron")
SubClassOf(obo:CL_0000532 obo:CL_0000533)
@@ -10143,24 +10391,25 @@ SubClassOf(obo:CL_0000532 obo:CL_0000533)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:1842357") obo:IAO_0000115 obo:CL_0000533 "A primary neuron (sensu Teleostei) that has a motor function.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000533 "ZFA:0009244")
AnnotationAssertion(rdfs:label obo:CL_0000533 "primary motor neuron (sensu Teleostei)")
-SubClassOf(obo:CL_0000533 obo:CL_0000100)
SubClassOf(obo:CL_0000533 obo:CL_0000530)
+SubClassOf(obo:CL_0000533 obo:CL_0011001)
# Class: obo:CL_0000534 (primary interneuron (sensu Teleostei))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:1842357") obo:IAO_0000115 obo:CL_0000534 "A primary neuron (sensu Teleostei) that is neither a sensory neuron or a motor neuron.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000534 "ZFA:0009245")
AnnotationAssertion(rdfs:label obo:CL_0000534 "primary interneuron (sensu Teleostei)")
-SubClassOf(obo:CL_0000534 obo:CL_0000099)
SubClassOf(obo:CL_0000534 obo:CL_0000530)
+SubClassOf(obo:CL_0000534 obo:CL_0005000)
# Class: obo:CL_0000535 (secondary neuron (sensu Teleostei))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:1842357") Annotation(oboInOwl:hasDbXref "doi:10.1242/dev.108.1.121") obo:IAO_0000115 obo:CL_0000535 "A neuron of teleosts that develops later than a primary neuron, typically during the larval stages.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000535 "ZFA:0009246")
AnnotationAssertion(rdfs:label obo:CL_0000535 "secondary neuron (sensu Teleostei)")
-SubClassOf(obo:CL_0000535 obo:BFO_0000002)
-SubClassOf(obo:CL_0000535 obo:CL_0000540)
+SubClassOf(obo:CL_0000535 obo:CL_2000029)
+SubClassOf(obo:CL_0000535 obo:UBERON_0010313)
+SubClassOf(obo:CL_0000535 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002240))
SubClassOf(Annotation(obo:IAO_0000233 "https://github.com/obophenotype/cell-ontology/pull/1950") obo:CL_0000535 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_32443))
# Class: obo:CL_0000536 (secondary motor neuron (sensu Teleostei))
@@ -10169,8 +10418,8 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:1842357") obo:IAO_000011
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000536 "ZFA:0009247")
AnnotationAssertion(rdfs:label obo:CL_0000536 "secondary motor neuron (sensu Teleostei)")
EquivalentClasses(obo:CL_0000536 ObjectIntersectionOf(obo:CL_0000100 obo:CL_0000535))
-SubClassOf(obo:CL_0000536 obo:CL_0000100)
SubClassOf(obo:CL_0000536 obo:CL_0000535)
+SubClassOf(obo:CL_0000536 obo:CL_0011001)
# Class: obo:CL_0000537 (obsolete antipodal cell)
@@ -10325,7 +10574,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000547 "proerythroblast")
EquivalentClasses(obo:CL_0000547 ObjectIntersectionOf(obo:CL_0000764 ObjectSomeValuesFrom(obo:BFO_0000051 obo:CL_0017503) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005730) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001083) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001839) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001889) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002978) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0002505) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0040072) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001945)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000547 obo:CL_0000764)
SubClassOf(obo:CL_0000547 obo:CL_0002242)
-SubClassOf(obo:CL_0000547 obo:PR_000050567)
SubClassOf(obo:CL_0000547 ObjectSomeValuesFrom(obo:BFO_0000051 obo:CL_0017503))
SubClassOf(obo:CL_0000547 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005730))
SubClassOf(obo:CL_0000547 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002))
@@ -10349,7 +10597,6 @@ AnnotationAssertion(obo:IAO_0000115 obo:CL_0000548 "OBSOLETE. A native cell that
AnnotationAssertion(obo:IAO_0000233 obo:CL_0000548 )
AnnotationAssertion(obo:IAO_0100001 obo:CL_0000548 obo:CL_0000000)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000548 "metazoan cell")
-AnnotationAssertion(oboInOwl:inSubset obo:CL_0000548 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000548 ubprop:_upper_level)
AnnotationAssertion(rdfs:label obo:CL_0000548 "obsolete animal cell")
AnnotationAssertion(owl:deprecated obo:CL_0000548 "true"^^xsd:boolean)
@@ -10367,7 +10614,6 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "ISBN:0721601464") oboInOwl:ha
AnnotationAssertion(rdfs:label obo:CL_0000549 "basophilic erythroblast")
EquivalentClasses(obo:CL_0000549 ObjectIntersectionOf(obo:CL_0000765 ObjectSomeValuesFrom(obo:BFO_0000051 obo:CL_0017503) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0000792) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001945)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000549 obo:CL_0000765)
-SubClassOf(obo:CL_0000549 obo:PR_000050567)
SubClassOf(obo:CL_0000549 ObjectSomeValuesFrom(obo:BFO_0000051 obo:CL_0017503))
SubClassOf(obo:CL_0000549 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0000792))
SubClassOf(obo:CL_0000549 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001945))
@@ -10386,7 +10632,6 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "ISBN:0721601464") oboInOwl:ha
AnnotationAssertion(rdfs:label obo:CL_0000550 "polychromatophilic erythroblast")
EquivalentClasses(obo:CL_0000550 ObjectIntersectionOf(obo:CL_0000765 ObjectSomeValuesFrom(obo:BFO_0000051 obo:CL_0017504) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0000792) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001945)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000550 obo:CL_0000765)
-SubClassOf(obo:CL_0000550 obo:PR_000050567)
SubClassOf(obo:CL_0000550 ObjectSomeValuesFrom(obo:BFO_0000051 obo:CL_0017504))
SubClassOf(obo:CL_0000550 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0000792))
SubClassOf(obo:CL_0000550 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001945))
@@ -10464,7 +10709,7 @@ SubClassOf(obo:CL_0000554 obo:CL_0000167)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000555 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000555 "neuronal brush cell")
-SubClassOf(obo:CL_0000555 obo:CL_0000117)
+SubClassOf(obo:CL_0000555 obo:CL_2000029)
# Class: obo:CL_0000556 (megakaryocyte)
@@ -10490,8 +10735,13 @@ DisjointClasses(obo:CL_0000556 obo:CL_0000764)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:dsd") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "ISBN:0721601464") Annotation(oboInOwl:hasDbXref "MESH:D055014") Annotation(oboInOwl:hasDbXref "PMCID:PMC2213186") Annotation(oboInOwl:hasDbXref "PMCID:PMC548021") Annotation(oboInOwl:hasDbXref "PMID:16551251") Annotation(oboInOwl:hasDbXref "PMID:16647566") Annotation(oboInOwl:hasDbXref "http://en.wikipedia.org/wiki/CFU-GM") Annotation(oboInOwl:hasDbXref "http://www.copewithcytokines.de") obo:IAO_0000115 obo:CL_0000557 "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000557 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.immuni.2017.10.021") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-immunol-081022113627") Annotation(oboInOwl:hasDbXref "DOI:10.1186/2050-7771-2-1") terms:description obo:CL_0000557 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Granulocyte monocyte progenitor cells (GMP cells), originating from hematopoietic stem cells in the bone marrow, are a critical intermediate in myeloid cell development. Positioned at a key differentiation juncture, these cells exhibit bidirectional potential, giving rise to both granulocyte and monocyte lineages.
+Their primary role is to generate mature granulocytes and monocytes, essential components of the body's innate immunity and inflammatory responses. Granulocytes, such as neutrophils, eosinophils, and basophils, contribute to the first line of defense against infections by migrating to the infection site and phagocytosing pathogens. Monocytes can differentiate into macrophages or dendritic cells, playing diverse roles in immune responses.")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "http://www.copewithcytokines.de") oboInOwl:hasBroadSynonym obo:CL_0000557 "CFU-C , Colony forming unit in culture")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000557 "ZFA:0009251")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000557 "https://cellxgene.cziscience.com/cellguide/CL_0000557")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "ISBN:0721601464") Annotation(oboInOwl:hasDbXref "PMCID:PMC2213186") Annotation(oboInOwl:hasDbXref "PMCID:PMC548021") oboInOwl:hasExactSynonym obo:CL_0000557 "colony forming unit granulocyte macrophage")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "ISBN:0721601464") Annotation(oboInOwl:hasDbXref "PMCID:PMC2213186") Annotation(oboInOwl:hasDbXref "PMCID:PMC548021") oboInOwl:hasExactSynonym obo:CL_0000557 "granulocyte-macrophage progenitor")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000557 "granulocyte/monocyte precursor")
@@ -10505,9 +10755,7 @@ AnnotationAssertion(rdfs:label obo:CL_0000557 "granulocyte monocyte progenitor c
EquivalentClasses(obo:CL_0000557 ObjectIntersectionOf(obo:CL_0002032 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002371) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001944) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000005307) ObjectSomeValuesFrom(obo:CL_4030045 obo:PR_000007857) ObjectSomeValuesFrom(obo:CL_4030045 obo:PR_000007858) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001865) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0030225) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0030851)))
SubClassOf(obo:CL_0000557 obo:CL_0000763)
SubClassOf(obo:CL_0000557 obo:CL_0001012)
-SubClassOf(obo:CL_0000557 obo:CL_0011026)
SubClassOf(obo:CL_0000557 obo:CL_1001610)
-SubClassOf(obo:CL_0000557 obo:PR_000050567)
SubClassOf(obo:CL_0000557 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001944))
SubClassOf(obo:CL_0000557 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000005307))
SubClassOf(obo:CL_0000557 ObjectSomeValuesFrom(obo:CL_4030045 obo:PR_000007857))
@@ -10528,7 +10776,6 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0000558 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000558 "reticulocyte")
EquivalentClasses(obo:CL_0000558 ObjectIntersectionOf(obo:CL_0000764 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001083) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001839) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001889) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002978) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001945) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0071971)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000558 obo:CL_0000764)
-SubClassOf(obo:CL_0000558 obo:PR_000050567)
SubClassOf(obo:CL_0000558 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002))
SubClassOf(obo:CL_0000558 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004))
SubClassOf(obo:CL_0000558 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012))
@@ -10558,7 +10805,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000559 "promonocyte")
EquivalentClasses(obo:CL_0000559 ObjectIntersectionOf(obo:CL_0002194 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0042582) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0030224)))
SubClassOf(obo:CL_0000559 obo:CL_0000763)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000559 obo:CL_0002194)
-SubClassOf(obo:CL_0000559 obo:PR_000050567)
SubClassOf(obo:CL_0000559 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0042582))
SubClassOf(obo:CL_0000559 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001012))
SubClassOf(obo:CL_0000559 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000040))
@@ -10664,7 +10910,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000566 "angioblastic mesenchymal cell")
EquivalentClasses(obo:CL_0000566 ObjectIntersectionOf(obo:CL_0000134 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001444) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002112) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000016043)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000566 obo:CL_0000134)
SubClassOf(obo:CL_0000566 obo:CL_0011026)
-SubClassOf(obo:CL_0000566 obo:PR_000050567)
SubClassOf(obo:CL_0000566 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001444))
SubClassOf(obo:CL_0000566 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002112))
SubClassOf(obo:CL_0000566 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000016043))
@@ -10709,10 +10954,10 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:68653") oboInOwl:hasExact
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:68653") oboInOwl:hasExactSynonym obo:CL_0000570 "thyroid parafollicular cell")
AnnotationAssertion(rdfs:label obo:CL_0000570 "parafollicular cell")
EquivalentClasses(obo:CL_0000570 ObjectIntersectionOf(obo:CL_0000710 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001024) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0001820) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0014046) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0036161)))
+SubClassOf(obo:CL_0000570 obo:CL_0000150)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000570 obo:CL_0000443)
SubClassOf(obo:CL_0000570 obo:CL_0000458)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000570 obo:CL_0000710)
-SubClassOf(obo:CL_0000570 obo:PR_000050567)
SubClassOf(obo:CL_0000570 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001747))
SubClassOf(obo:CL_0000570 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001024))
SubClassOf(obo:CL_0000570 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000333))
@@ -10804,7 +11049,7 @@ SubClassOf(obo:CL_0000576 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0043011))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:9505449") obo:IAO_0000115 obo:CL_0000577 "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain).")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000577 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/0166-4328(96)00075-7") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.cell.2017.05.034") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41574-019-0168-8") Annotation(oboInOwl:hasDbXref "DOI:10.1073/pnas.1804938115") terms:description obo:CL_0000577 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/0166-4328(96)00075-7") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.cell.2017.05.034") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41574-019-0168-8") Annotation(oboInOwl:hasDbXref "DOI:10.1073/pnas.1804938115") terms:description obo:CL_0000577 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Type EC enteroendocrine cells, also known as enterochromaffin cells, are a vital hormone-secreting cell type found in the gastrointestinal tract. These cells are named after their location in the intestines (“entero”) and because they are stainable by chromium salts (“chromaffin”).
The primary function of type EC enteroendocrine cells is to act as chemosensors and lies in their capacity to produce and secrete serotonin, also known as 5-hydroxytryptamine (5-HT). Serotonin is a neurotransmitter that plays a significant role in modulating motility, secretion, vasodilation, perception of pain, and appetite in the gastrointestinal system. However, its function is not limited to the gastrointestinal tract; once secreted, serotonin is distributed via the bloodstream and contributes to regulating mood, appetite, and sleep in the brain.
@@ -10823,7 +11068,6 @@ SubClassOf(obo:CL_0000577 obo:CL_0000164)
SubClassOf(obo:CL_0000577 obo:CL_0000166)
SubClassOf(obo:CL_0000577 obo:CL_0000458)
SubClassOf(obo:CL_0000577 obo:CL_0000506)
-SubClassOf(obo:CL_0000577 obo:CL_0002251)
SubClassOf(obo:CL_0000577 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004786))
# Class: obo:CL_0000578 (experimentally modified cell in vitro)
@@ -10877,7 +11121,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000581 "Markers: Mouse: F4/80-high, CD1
AnnotationAssertion(rdfs:label obo:CL_0000581 "peritoneal macrophage")
EquivalentClasses(obo:CL_0000581 ObjectIntersectionOf(obo:CL_0000864 ObjectSomeValuesFrom(obo:CL_4030046 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0001025 obo:UBERON_0001179) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001807) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002064) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000006172) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0042742) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001813) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000002062)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000581 obo:CL_0000864)
-SubClassOf(obo:CL_0000581 obo:PR_000050567)
SubClassOf(obo:CL_0000581 ObjectSomeValuesFrom(obo:CL_4030046 obo:GO_0042613))
SubClassOf(obo:CL_0000581 ObjectSomeValuesFrom(obo:RO_0001025 obo:UBERON_0001179))
SubClassOf(obo:CL_0000581 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001807))
@@ -10922,7 +11165,7 @@ SubClassOf(obo:CL_0000582 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000580))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:ana") Annotation(oboInOwl:hasDbXref "GOC:dsd") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "MESH:D016676") obo:IAO_0000115 obo:CL_0000583 "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000583 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00424-017-1965-3") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.cellimm.2018.01.005") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri3600") Annotation(oboInOwl:hasDbXref "DOI:10.14348/molcells.2021.0058") terms:description obo:CL_0000583 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00424-017-1965-3") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.cellimm.2018.01.005") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri3600") Annotation(oboInOwl:hasDbXref "DOI:10.14348/molcells.2021.0058") terms:description obo:CL_0000583 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Alveolar macrophages are unique tissue-resident macrophages found in the lungs, specifically in the air sacs or alveoli where gas exchange occurs. They are characterized by specific surface markers including: F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative. These specialized immune cells form a crucial part of the body's defense mechanism, playing important roles in pulmonary health and homeostasis. They are the first line of defense in the pulmonary immune response, acting as scavengers that patrol the alveoli and engulf foreign particles like bacteria, dust, and other debris that enter the lungs through inhalation.
The primary function of these alveolar macrophages is phagocytosis, whereby they consume and digest foreign substances, dead cells, and other particulates. In the lung, alveolar macrophages are also responsible for clearing surfactant. Additionally, alveolar macrophages also play an integral role in initiating the immune response, as they secrete several pro-inflammatory cytokines and chemokines that recruit other immune cells to the site of infection or inflammation.
@@ -10936,11 +11179,11 @@ AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_0000583 "MF.Lu")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000583 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000583 core:human_reference_atlas)
AnnotationAssertion(rdfs:comment obo:CL_0000583 "Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_0000583 "The marker set MSR1, FABP4 can identify the Human cell type alveolar macrophage in the Lung with a confidence of 0.80 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_0000583 "alveolar macrophage")
EquivalentClasses(obo:CL_0000583 ObjectIntersectionOf(obo:CL_0000864 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001206) ObjectSomeValuesFrom(obo:RO_0001025 obo:UBERON_8850000) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001013) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001807) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001813) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001931) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002064) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002972) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0019882) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001012)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000583 obo:CL_0000864)
SubClassOf(obo:CL_0000583 obo:CL_1001603)
-SubClassOf(obo:CL_0000583 obo:PR_000050567)
SubClassOf(obo:CL_0000583 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001206))
SubClassOf(obo:CL_0000583 ObjectSomeValuesFrom(obo:RO_0001025 obo:UBERON_8850000))
SubClassOf(obo:CL_0000583 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001013))
@@ -10949,6 +11192,7 @@ SubClassOf(obo:CL_0000583 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001813))
SubClassOf(obo:CL_0000583 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001931))
SubClassOf(obo:CL_0000583 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002064))
SubClassOf(obo:CL_0000583 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002972))
+SubClassOf(obo:CL_0000583 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000003))
SubClassOf(obo:CL_0000583 ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001012))
# Class: obo:CL_0000584 (enterocyte)
@@ -10967,6 +11211,7 @@ AnnotationAssertion(rdfs:label obo:CL_0000584 "enterocyte")
SubClassOf(obo:CL_0000584 obo:CL_0000239)
SubClassOf(obo:CL_0000584 obo:CL_0000677)
SubClassOf(obo:CL_0000584 obo:CL_0002563)
+SubClassOf(obo:CL_0000584 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_4047019))
# Class: obo:CL_0000585 (obsolete null cell)
@@ -11053,7 +11298,13 @@ SubClassOf(obo:CL_0000593 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0035935))
# Class: obo:CL_0000594 (skeletal muscle satellite cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "MESH:D032496") Annotation(oboInOwl:hasDbXref "PMID:21849021") Annotation(oboInOwl:hasDbXref "PMID:23303905") obo:IAO_0000115 obo:CL_0000594 "An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/s1357-2725(03)00042-6") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00061.2017") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s13287-022-02706-5") Annotation(oboInOwl:hasDbXref "DOI:10.1369/0022155411426780") Annotation(oboInOwl:hasDbXref "DOI:10.22074/cellj.2016.4714") terms:description obo:CL_0000594 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Skeletal muscle satellite cells (SMSCs) are a type of adult stem cell that nestles on the outer surface of the myofiber, positioned between the sarcolemma (plasma membrane of the muscle cell) and peripheral basement membrane.
+The primary function of SMSCs lies in their capacity to facilitate the growth and repair of damaged skeletal muscle. Upon muscle injury or trauma, these normally quiescent cells activate, proliferate, and differentiate into myoblasts. These myoblasts subsequently mature and fuse to form myotubes, which ultimately help in the repair and rebuilding of muscle fibers. This response is an integral part of the skeletal muscle's ability to recover from injury and adapt to enhanced or changing physical demands, thereby maintaining and improving muscle function.
+Furthermore, SMSCs also contribute to hypertrophic muscle growth due to resistance exercise and endurance training, with the notable feature of their multi-nucleated nature resulting from the fusion of differentiated myoblasts. The additional nuclei support enhanced protein synthesis, thus allowing the muscle fibers to grow and strengthen in response to exercise. In aging and in diseases, the number or functionality of these cells can decrease, leading to impaired muscle regeneration and progressive muscle weakness.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000594 "ZFA:0009272")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000594 "https://cellxgene.cziscience.com/cellguide/CL_0000594")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000594 cl:cellxgene_subset)
AnnotationAssertion(rdfs:comment obo:CL_0000594 "Skeletal muscle satellite cells are not traditionally referred to as myoblasts. They are a heterogeneous population whose division, following activiation, contributes to the formation of skeletal muscle fibers and to maintenance of the skeletal muscle statelite cell population.")
AnnotationAssertion(rdfs:label obo:CL_0000594 "skeletal muscle satellite cell")
@@ -11101,7 +11352,7 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0000598 cl:BDS_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000598 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000598 "pyramidal neuron")
EquivalentClasses(obo:CL_0000598 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070015)))
-SubClassOf(obo:CL_0000598 obo:CL_0000104)
+SubClassOf(obo:CL_0000598 obo:CL_2000029)
SubClassOf(obo:CL_0000598 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070015))
# Class: obo:CL_0000599 (conidium)
@@ -11212,7 +11463,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000611 "eosinophil progenitor cell")
EquivalentClasses(obo:CL_0000611 ObjectIntersectionOf(obo:CL_0002191 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001944) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000005307) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007857) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001083) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001839) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001889) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002978) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002981) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001408) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001865) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001867) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002065) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0030222)))
SubClassOf(obo:CL_0000611 obo:CL_0000763)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000611 obo:CL_0002191)
-SubClassOf(obo:CL_0000611 obo:PR_000050567)
SubClassOf(obo:CL_0000611 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001944))
SubClassOf(obo:CL_0000611 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000005307))
SubClassOf(obo:CL_0000611 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007857))
@@ -11266,7 +11516,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000613 "basophil progenitor cell")
EquivalentClasses(obo:CL_0000613 ObjectIntersectionOf(obo:CL_0002191 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000005307) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007857) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007858) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001083) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001839) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001889) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002065) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002978) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002981) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0030221) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000007431) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000016401)))
SubClassOf(obo:CL_0000613 obo:CL_0000763)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000613 obo:CL_0002191)
-SubClassOf(obo:CL_0000613 obo:PR_000050567)
SubClassOf(obo:CL_0000613 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000005307))
SubClassOf(obo:CL_0000613 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007857))
SubClassOf(obo:CL_0000613 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007858))
@@ -11363,7 +11612,7 @@ SubClassOf(obo:CL_0000621 obo:CL_0008018)
# Class: obo:CL_0000622 (acinar cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.copewithcytokines.de") obo:IAO_0000115 obo:CL_0000622 "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus).")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/BF00710764") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrgastro.2013.36") Annotation(oboInOwl:hasDbXref "DOI:10.1097/MOG.0b013e32832ebfac") Annotation(oboInOwl:hasDbXref "DOI:10.1111/prd.12116") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00011.2011") terms:description obo:CL_0000622 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/BF00710764") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrgastro.2013.36") Annotation(oboInOwl:hasDbXref "DOI:10.1097/MOG.0b013e32832ebfac") Annotation(oboInOwl:hasDbXref "DOI:10.1111/prd.12116") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00011.2011") terms:description obo:CL_0000622 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Acinar cells are specialized exocrine gland cells that secrete specific enzymes and fluids to aid in digestion. Found primarily in the pancreas and salivary glands, the term acinar is derived from the Latin word 'acinus' which means 'grape'; this is because acinar cells are arranged in a grape-like cluster around small ducts, formulating an acinus structure.
In the salivary glands, acinar cells secrete digestive enzymes as well as other substances such as mucus and water. These secretions service the initial stages of the digestive process, preparing the consumed food for onward digestion in the stomach and intestines by lubricating and partially breaking it down.
@@ -11377,6 +11626,7 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000622 "acinic cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000622 "acinous cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000622 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000622 "acinar cell")
+EquivalentClasses(obo:CL_0000622 ObjectIntersectionOf(obo:CL_0000150 obo:CL_0000154 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009842)))
SubClassOf(obo:CL_0000622 obo:CL_0000150)
SubClassOf(obo:CL_0000622 obo:CL_0000154)
SubClassOf(obo:CL_0000622 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009842))
@@ -11448,7 +11698,6 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1038/s41598-018-27692-
AnnotationAssertion(rdfs:label obo:CL_0000626 "olfactory granule cell")
EquivalentClasses(obo:CL_0000626 ObjectIntersectionOf(obo:CL_0000120 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005378)))
SubClassOf(obo:CL_0000626 obo:CL_0000120)
-SubClassOf(obo:CL_0000626 obo:CL_0012001)
SubClassOf(obo:CL_0000626 obo:CL_1001434)
SubClassOf(obo:CL_0000626 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005378))
SubClassOf(obo:CL_0000626 ObjectSomeValuesFrom(obo:RO_0002103 obo:CL_1001502))
@@ -11514,7 +11763,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000632 "hepatic stellate cell")
EquivalentClasses(obo:CL_0000632 ObjectIntersectionOf(obo:CL_0002320 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002107) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000007939)))
SubClassOf(obo:CL_0000632 obo:CL_0000057)
SubClassOf(obo:CL_0000632 obo:CL_0000327)
-SubClassOf(obo:CL_0000632 obo:PR_000050567)
SubClassOf(obo:CL_0000632 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002107))
SubClassOf(obo:CL_0000632 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000007939))
@@ -11748,7 +11996,9 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000652 "BTO:0001068")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000652 "FMA:83417")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000652 "ZFA:0009284")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000652 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000652 "pinealocyte")
+SubClassOf(obo:CL_0000652 obo:CL_0000150)
SubClassOf(obo:CL_0000652 obo:CL_0000163)
SubClassOf(obo:CL_0000652 obo:CL_0000710)
SubClassOf(obo:CL_0000652 obo:CL_0002319)
@@ -11759,7 +12009,7 @@ SubClassOf(obo:CL_0000652 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0030187))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "https://doi.org/10.1101/2021.10.10.463829") obo:IAO_0000115 obo:CL_0000653 "A specialized kidney epithelial cell, contained within a glomerulus, that contains \"feet\" that interdigitate with the \"feet\" of other podocytes.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000653 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41467-022-33748-1") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41572-020-0196-7") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-020911-153238") Annotation(oboInOwl:hasDbXref "DOI:10.1159/000481633") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fcell.2021.771931") terms:description obo:CL_0000653 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41467-022-33748-1") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41572-020-0196-7") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-020911-153238") Annotation(oboInOwl:hasDbXref "DOI:10.1159/000481633") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fcell.2021.771931") terms:description obo:CL_0000653 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Podocytes are highly specialized, terminally differentiated glomerular visceral epithelial cells that wrap around the capillaries in the kidneys. They play an essential role in kidney function, particularly in the filtration selectivity of the glomerulus. Each podocyte is characterized by a unique architecture with a large cell body, ‘major processes’ extending outwardly from the cell body and ‘foot processes’, also known as pedicels, which surround. the glomerular capillary loops
Podocytes represent the last barrier of the glomerular filtration membrane in the kidney. This barrier prevents the leakage of plasma proteins from the blood into the urine, hence maintaining protein homeostasis in the body. The foot processes of the podocytes interdigitate with those from neighboring cells. The cell-cell junctions between the foot processes, the slit-diaphragms, are thought to create a molecular sensor of renal filtration that prevents the passage of macromolecules while allowing water and small solutes to pass.
@@ -11891,7 +12141,7 @@ AnnotationAssertion(owl:deprecated obo:CL_0000665 "true"^^xsd:boolean)
# Class: obo:CL_0000666 (fenestrated endothelial cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/978-3-211-99390-3_133") obo:IAO_0000115 obo:CL_0000666 "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/ar.1092200109") Annotation(oboInOwl:hasDbXref "DOI:10.1016/0306-4522(86)90162-4") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.devcel.2012.11.003") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41467-022-31571-2") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajprenal.90601.2008") terms:description obo:CL_0000666 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/ar.1092200109") Annotation(oboInOwl:hasDbXref "DOI:10.1016/0306-4522(86)90162-4") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.devcel.2012.11.003") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41467-022-31571-2") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajprenal.90601.2008") terms:description obo:CL_0000666 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Fenestrated cells are specialized epithelial cells that are characterized by a distinctive structural feature, fenestrations or tiny pores, which allow an exchange of substances such as fluids, nutrients, and waste between blood vessels and the surrounding tissue environments. These cells are present in various types of epithelial tissues in the human body, including the intestinal tract, endocrine glands, and certain parts of the renal system.
There are multiple types of endothelial cell fenestrations. The most common type is found in systemic capillaries of the endocrine tissue (e.g., pancreatic islets), gastrointestinal mucosa, and renal peritubular capillaries. Here, the fenestrated cells have fenestrations in their peripheral cytoplasm with a unique thin and permeable diaphragm that provides a high degree of selectivity, blocking the passage of larger molecules while allowing the free movement of smaller ones. In contrast, other types of fenestrations, such as the discontinuous epithelium of the liver sinusoidal endothelial cells, do not have diaphragms.
@@ -12018,8 +12268,10 @@ SubClassOf(obo:CL_0000677 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000127
# Class: obo:CL_0000678 (commissural neuron)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:17560562") Annotation(oboInOwl:hasDbXref "PMID:31693445") obo:IAO_0000115 obo:CL_0000678 "A neuron with soma location in the central nervous system that project its axon to the contralateral side of a central nervous system. This neuron can have its soma in the spinal cord, in the hemisphere of the brain, in the retina or in the ventral nerve cord of invertebrates.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25960414") Annotation(oboInOwl:hasDbXref "PMID:27532244") Annotation(oboInOwl:hasDbXref "PMID:31514748") Annotation(oboInOwl:hasDbXref "PMID:33438755") rdfs:comment obo:CL_0000678 "Historically, commissural neurons, particularly in the spinal cord, have been used as a model to understand axon guidance during development.")
AnnotationAssertion(rdfs:label obo:CL_0000678 "commissural neuron")
-SubClassOf(obo:CL_0000678 obo:CL_0000540)
+SubClassOf(obo:CL_0000678 obo:CL_2000029)
# Class: obo:CL_0000679 (glutamatergic neuron)
@@ -12065,7 +12317,7 @@ SubClassOf(obo:CL_0000681 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000710))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:jb") Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0000682 "An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000682 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nature08529") Annotation(oboInOwl:hasDbXref "DOI:10.1093/jb/mvv121") Annotation(oboInOwl:hasDbXref "DOI:10.1136/gut.47.5.735") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK534232/") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/medicine-and-dentistry/microfold-cell") terms:description obo:CL_0000682 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nature08529") Annotation(oboInOwl:hasDbXref "DOI:10.1093/jb/mvv121") Annotation(oboInOwl:hasDbXref "DOI:10.1136/gut.47.5.735") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK534232/") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/medicine-and-dentistry/microfold-cell") terms:description obo:CL_0000682 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
M cells, or microfold cells, of the gut are specialized epithelial cells found in the lining of the gut, specifically in the follicle-associated epithelium of mucosa-associated lymphoid tissue, where they function as sentries against toxins and pathogens. M cells are characterized by apical microfolds (hence their alternate name) which express unique adhesion molecules that enable them to sample the luminal macromolecules.
Other morphological features that distinguish M cells from other intestinal mucosal cells include sparse microvilli and a reduced thickness of the glycocalyx, which permits adhesion while not hindering the transport of molecules. They also have unique intraepithelial invaginations on the basolateral side which are filled with macrophages and other immune cells that can process the engulfed macromolecules quickly.
@@ -12084,7 +12336,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000682 "M cell of gut")
SubClassOf(obo:CL_0000682 obo:CL_0000473)
SubClassOf(obo:CL_0000682 obo:CL_0000627)
SubClassOf(obo:CL_0000682 obo:CL_0002251)
-SubClassOf(obo:CL_0000682 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003929))
# Class: obo:CL_0000683 (ependymoglial cell)
@@ -12114,8 +12365,8 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000686 "ZFA:0009295")
AnnotationAssertion(rdfs:label obo:CL_0000686 "cerebrospinal fluid secreting cell")
EquivalentClasses(obo:CL_0000686 ObjectIntersectionOf(obo:CL_0000151 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0033326)))
-SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000686 obo:CL_0000151)
SubClassOf(obo:CL_0000686 obo:CL_0000710)
+SubClassOf(obo:CL_0000686 obo:CL_1100001)
SubClassOf(obo:CL_0000686 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000333))
SubClassOf(obo:CL_0000686 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0033326))
@@ -12159,8 +12410,7 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0000691 cl:BDS_subset)
AnnotationAssertion(rdfs:label obo:CL_0000691 "stellate interneuron")
EquivalentClasses(obo:CL_0000691 ObjectIntersectionOf(obo:CL_0000099 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070010)))
SubClassOf(obo:CL_0000691 obo:CL_0000099)
-SubClassOf(obo:CL_0000691 obo:CL_0000104)
-SubClassOf(obo:CL_0000691 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070010))
+SubClassOf(obo:CL_0000691 obo:CL_0000122)
# Class: obo:CL_0000692 (terminal Schwann cell)
@@ -12185,7 +12435,6 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0000693 cl:BDS_subset)
AnnotationAssertion(rdfs:label obo:CL_0000693 "neurogliaform cell")
EquivalentClasses(obo:CL_0000693 ObjectIntersectionOf(obo:CL_0000099 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070001)))
SubClassOf(obo:CL_0000693 obo:CL_0000099)
-SubClassOf(obo:CL_0000693 obo:CL_0000104)
SubClassOf(obo:CL_0000693 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070001))
# Class: obo:CL_0000694 (R3 photoreceptor cell)
@@ -12207,7 +12456,6 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "WikipediaVersioned:Cajal–Re
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000695 cl:cellxgene_subset)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:10600995") rdfs:comment obo:CL_0000695 "While previously called 'pioneer neurons' of the marginal zone, Cajal-Retzius cells are differentiated from pioneer neurons (which are Reln-negative) by their Reln-immunoreactivity.")
AnnotationAssertion(rdfs:label obo:CL_0000695 "Cajal-Retzius cell")
-SubClassOf(obo:CL_0000695 obo:CL_0000117)
SubClassOf(obo:CL_0000695 obo:CL_2000029)
SubClassOf(obo:CL_0000695 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070006))
SubClassOf(obo:CL_0000695 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0010403))
@@ -12215,7 +12463,7 @@ SubClassOf(obo:CL_0000695 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0010403
# Class: obo:CL_0000696 (PP cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "JB:jb") Annotation(oboInOwl:hasDbXref "PMID:15153415") obo:IAO_0000115 obo:CL_0000696 "A cell that stores and secretes pancreatic polypeptide hormone.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.febslet.2014.07.005") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.mce.2015.06.028") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41580-020-00317-7") Annotation(oboInOwl:hasDbXref "DOI:10.1210/jc.2003-030630") Annotation(oboInOwl:hasDbXref "DOI:10.1369/00221554155835") terms:description obo:CL_0000696 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.febslet.2014.07.005") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.mce.2015.06.028") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41580-020-00317-7") Annotation(oboInOwl:hasDbXref "DOI:10.1210/jc.2003-030630") Annotation(oboInOwl:hasDbXref "DOI:10.1369/00221554155835") terms:description obo:CL_0000696 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
PP cells, also known as pancreatic polypeptide cells (and previously called F cells or gamma cells), are enteroendocrine cells predominantly found in the islets of Langerhans in the head of the pancreas. They are one of the four main endocrine cell types present in the pancreatic islets, along with type A, B and D cells. PP cells are notable for their production of pancreatic polypeptide, an anorexigenic hormone that modulates food intake and energy homeostasis.
By secreting pancreatic polypeptide, PP cells play a significant role in the management of both digestive and appetite regulation. Upon ingestion of food, there is a significant increase in the secretion of pancreatic polypeptide, which then reduces biliary secretion and helps slow down the movement of food through the digestive tract. This allows more time for digestion to take place and nutrients to be absorbed, promoting the efficient use of dietary intake. The pancreatic polypeptide further reduces appetite by interacting with the hypothalamus, the area of the brain responsible for control of hunger.
@@ -12522,7 +12770,7 @@ SubClassOf(obo:CL_0000730 obo:CL_0000066)
# Class: obo:CL_0000731 (urothelial cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "MA:ma") Annotation(oboInOwl:hasDbXref "doi:10.1038/s41385-022-00565-0") obo:IAO_0000115 obo:CL_0000731 "A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/nau.22195") Annotation(oboInOwl:hasDbXref "DOI:10.1038/ki.2009.73") Annotation(oboInOwl:hasDbXref "DOI:10.1038/ncpuro0672") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41579-020-0324-0") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00041.2019") terms:description obo:CL_0000731 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/nau.22195") Annotation(oboInOwl:hasDbXref "DOI:10.1038/ki.2009.73") Annotation(oboInOwl:hasDbXref "DOI:10.1038/ncpuro0672") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41579-020-0324-0") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00041.2019") terms:description obo:CL_0000731 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Urothelial cells are a unique type of epithelial cell found lining the urinary tract system. They form the urothelium, a specialized, multi-layered epithelium that lines major portions of the urinary tract, including the renal pelvis, ureters, bladder, and the proximal part of the urethra. The distinct characteristic of urothelial cells is their ability to stretch and contract depending on the volume of liquid they contain - a feature that facilitates the essential role they play in maintaining the functionality and integrity of the urinary system.
The primary function of urothelial cells is to provide an impermeable barrier to urine, preventing the toxic components present in the urine from seeping back into the body's bloodstream. The urothelium consists of a superficial umbrella cell layer, 1–2 layers of intermediate cells, and a basal cell layer. The umbrella layer is composed of large, mostly binucleated cells that are covered in an asymmetrical unit membrane, the uroplakin plaques. These plaques function to seal the apical membrane of the bladder from the toxic and highly variable contents of urine. The lipid bilayer structure of uroplakin plaques has an exceptionally high concentration of uroplakins that contribute to the barrier function of the urothelium.
@@ -12633,7 +12881,7 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0000740 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000740 cl:eye_upper_slim)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000740 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0000740 "retinal ganglion cell")
-SubClassOf(obo:CL_0000740 obo:CL_0000117)
+SubClassOf(obo:CL_0000740 obo:CL_0000540)
SubClassOf(obo:CL_0000740 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000966))
# Class: obo:CL_0000741 (spinal accessory motor neuron)
@@ -12688,13 +12936,18 @@ SubClassOf(obo:CL_0000745 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0003902
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:mtg_cardiacconduct_nov11") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0323052908") Annotation(oboInOwl:hasDbXref "PMID:22426062") Annotation(oboInOwl:hasDbXref "PMID:4711263") obo:IAO_0000115 obo:CL_0000746 "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000746 obo:NCBITaxon_9606)
-AnnotationAssertion(oboInOwl:hasAlternativeId obo:CL_0000746 "FMA:83808")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.ccep.2010.10.012") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrcardio.2016.203") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK572070") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/cardiac-muscle") terms:description obo:CL_0000746 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Cardiac muscle cells, also known as cardiomyocytes or cardiac myocytes, are specialized cells that form the heart tissue. These cells are elongated, branched, and contain a single centrally located nucleus. Their anatomy is composed primarily of densely packed myofibrils, which are protein structures that consist of sarcomeres - the fundamental units of muscle contraction. Cardiac muscle cells are united at their ends through specialized junctions known as intercalated discs, which allow the heart to contract in a unified, powerful and rhythmic way.
+Functionally, cardiac muscle cells are responsible for the heart's consistent pumping action that circulates blood throughout the body. Unlike most cells in the body, cardiac muscle cells spontaneously depolarize and generate action potentials without external stimulation. This unique trait stems from the presence of ion channels in the cells' membrane that allow a cyclic flow of ions across the membrane, which create the electrical impulses necessary for heart contraction. The spread of these electrical signals from one cardiac muscle cell to another - facilitated by the interconnected network made by the intercalated disks - results in a synchronized contraction of the heart muscle.
+Unlike skeletal muscle cells which can tire and need rest, cardiac muscle cells have to work ceaselessly throughout the entire lifespan, without the opportunity for rest, to ensure continuous circulation of blood. This is made possible through the high volume of mitochondria and a constant supply of oxygen from coronary circulation. In conclusion, cardiac muscle cells, through their unique structure and vital functionality, play a pivotal role in sustaining life by providing the means for blood to reach every cell in the body.")
AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_0000746 "cardiocyte")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000746 "BTO:0001539")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000746 "CALOHA:TS-0115")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000746 "FMA:14067")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000746 "MESH:D032383")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000746 "ZFA:0009316")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000746 "https://cellxgene.cziscience.com/cellguide/CL_0000746")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GO:0048739") oboInOwl:hasExactSynonym obo:CL_0000746 "cardiac muscle fiber")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000746 "cardiac myocyte")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000746 "cardiomyocyte")
@@ -12734,8 +12987,7 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0000748 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000748 cl:eye_upper_slim)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000748 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0000748 "retinal bipolar neuron")
-EquivalentClasses(obo:CL_0000748 ObjectIntersectionOf(obo:CL_0000103 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0001791)))
-SubClassOf(obo:CL_0000748 obo:CL_0000103)
+EquivalentClasses(obo:CL_0000748 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0001791)))
SubClassOf(obo:CL_0000748 obo:CL_0000679)
SubClassOf(obo:CL_0000748 obo:CL_0008028)
SubClassOf(obo:CL_0000748 obo:CL_0009004)
@@ -12766,11 +13018,9 @@ SubClassOf(obo:CL_0000750 obo:CL_0000748)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:14689473") obo:IAO_0000115 obo:CL_0000751 "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells. These neurons depolarize in response to light.")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:38627529") obo:RO_0002175 obo:CL_0000751 obo:NCBITaxon_32443)
-AnnotationAssertion(obo:RO_0002175 obo:CL_0000751 obo:NCBITaxon_9606)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000751 "FMA:67750")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000751 "ZFA:0009321")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000751 cl:cellxgene_subset)
-AnnotationAssertion(oboInOwl:inSubset obo:CL_0000751 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0000751 "rod bipolar cell")
SubClassOf(obo:CL_0000751 obo:CL_0000749)
SubClassOf(obo:CL_0000751 ObjectSomeValuesFrom(obo:RO_0002102 obo:UBERON_0008925))
@@ -12781,6 +13031,7 @@ SubClassOf(obo:CL_0000751 ObjectSomeValuesFrom(obo:RO_0002103 obo:CL_0000604))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:14689473") obo:IAO_0000115 obo:CL_0000752 "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0000752 "ZFA:0009322")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000752 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000752 "cone retinal bipolar cell")
EquivalentClasses(obo:CL_0000752 ObjectIntersectionOf(obo:CL_0000748 ObjectSomeValuesFrom(obo:RO_0002103 obo:CL_0000573)))
SubClassOf(obo:CL_0000752 obo:CL_0000748)
@@ -12790,6 +13041,7 @@ SubClassOf(obo:CL_0000752 ObjectSomeValuesFrom(obo:RO_0002103 obo:CL_0000573))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:14689473") obo:IAO_0000115 obo:CL_0000753 "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000753 "DB1 cone bipolar cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000753 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000753 "type 1 cone bipolar cell (sensu Mus)")
SubClassOf(obo:CL_0000753 obo:CL_0000752)
SubClassOf(obo:CL_0000753 ObjectSomeValuesFrom(obo:RO_0002102 obo:UBERON_0008922))
@@ -12798,6 +13050,7 @@ SubClassOf(obo:CL_0000753 ObjectSomeValuesFrom(obo:RO_0002102 obo:UBERON_0008922
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:14689473") Annotation(oboInOwl:hasDbXref "PMID:27565351") obo:IAO_0000115 obo:CL_0000754 "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1 (Ghosh et al., 2004). It can be differentiated from other retinal bipolar neurons by its expression of marker genes: Neto1, Lhx3 and Irx-6 (Shekhar, 2016).")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000754 "FMB cone bipolar cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000754 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000754 "type 2 cone bipolar cell (sensu Mus)")
EquivalentClasses(Annotation(oboInOwl:hasDbXref "PMID:27565351") obo:CL_0000754 ObjectIntersectionOf(obo:CL_0000748 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_P50481) ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_Q8R4I7) ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_Q9ER75)))
SubClassOf(obo:CL_0000754 obo:BFO_0000002)
@@ -12820,6 +13073,7 @@ SubClassOf(obo:CL_0000755 ObjectSomeValuesFrom(obo:RO_0002103 obo:CL_0000604))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:14689473") obo:IAO_0000115 obo:CL_0000756 "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000756 "DB3 cone bipolar cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000756 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000756 "type 4 cone bipolar cell (sensu Mus)")
SubClassOf(obo:CL_0000756 obo:CL_0000752)
SubClassOf(obo:CL_0000756 ObjectSomeValuesFrom(obo:RO_0002102 obo:UBERON_0008923))
@@ -12830,6 +13084,7 @@ SubClassOf(obo:CL_0000756 ObjectSomeValuesFrom(obo:RO_0002103 obo:CL_0000604))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:14689473") obo:IAO_0000115 obo:CL_0000757 "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000757 "DB4 cone bipolar cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000757 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000757 "type 5 cone bipolar cell (sensu Mus)")
SubClassOf(obo:CL_0000757 obo:CL_0000752)
SubClassOf(obo:CL_0000757 ObjectSomeValuesFrom(obo:RO_0002102 obo:UBERON_0008924))
@@ -12838,6 +13093,7 @@ SubClassOf(obo:CL_0000757 ObjectSomeValuesFrom(obo:RO_0002102 obo:UBERON_0008924
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:14689473") obo:IAO_0000115 obo:CL_0000758 "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000758 "DB5 cone bipolar cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000758 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000758 "type 6 cone bipolar cell (sensu Mus)")
SubClassOf(obo:CL_0000758 obo:CL_0000752)
SubClassOf(obo:CL_0000758 ObjectSomeValuesFrom(obo:RO_0002102 obo:UBERON_0008925))
@@ -12846,6 +13102,7 @@ SubClassOf(obo:CL_0000758 ObjectSomeValuesFrom(obo:RO_0002102 obo:UBERON_0008925
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:14689473") obo:IAO_0000115 obo:CL_0000759 "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000759 "IMB cone bipolar cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000759 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000759 "type 7 cone bipolar cell (sensu Mus)")
SubClassOf(obo:CL_0000759 obo:CL_0000752)
SubClassOf(obo:CL_0000759 ObjectSomeValuesFrom(obo:RO_0002102 obo:UBERON_0008925))
@@ -12854,6 +13111,7 @@ SubClassOf(obo:CL_0000759 ObjectSomeValuesFrom(obo:RO_0002102 obo:UBERON_0008925
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:14689473") obo:IAO_0000115 obo:CL_0000760 "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000760 "DB6 cone bipolar cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000760 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000760 "type 8 cone bipolar cell (sensu Mus)")
SubClassOf(obo:CL_0000760 obo:CL_0000752)
SubClassOf(obo:CL_0000760 ObjectSomeValuesFrom(obo:RO_0002102 obo:UBERON_0008925))
@@ -12863,6 +13121,7 @@ SubClassOf(obo:CL_0000760 ObjectSomeValuesFrom(obo:RO_0002102 obo:UBERON_0008926
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:14689473") obo:IAO_0000115 obo:CL_0000761 "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000761 "BB cone bipolar cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000761 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000761 "type 9 cone bipolar cell (sensu Mus)")
SubClassOf(obo:CL_0000761 obo:CL_0000752)
SubClassOf(obo:CL_0000761 ObjectSomeValuesFrom(obo:RO_0002102 obo:UBERON_0008926))
@@ -13268,7 +13527,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000786 "Plasma cells develop in the spl
AnnotationAssertion(rdfs:label obo:CL_0000786 "plasma cell")
EquivalentClasses(obo:CL_0000786 ObjectIntersectionOf(obo:CL_0000946 ObjectSomeValuesFrom(obo:BFO_0000051 obo:CL_0017508) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005794) ObjectSomeValuesFrom(obo:CL_4030046 obo:GO_0019814) ObjectSomeValuesFrom(obo:CL_4030046 obo:GO_0042613) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001935)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000786 obo:CL_0000946)
-SubClassOf(obo:CL_0000786 obo:PR_000050567)
SubClassOf(obo:CL_0000786 ObjectSomeValuesFrom(obo:BFO_0000051 obo:CL_0017508))
SubClassOf(obo:CL_0000786 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005794))
SubClassOf(obo:CL_0000786 ObjectSomeValuesFrom(obo:CL_4030046 obo:GO_0019814))
@@ -13328,7 +13586,6 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0000789 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000789 "alpha-beta T cell")
EquivalentClasses(obo:CL_0000789 ObjectIntersectionOf(obo:CL_0000084 ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0042105)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000789 obo:CL_0000084)
-SubClassOf(obo:CL_0000789 obo:PR_000050567)
SubClassOf(obo:CL_0000789 ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0042105))
DisjointClasses(obo:CL_0000789 obo:CL_0000798)
@@ -13489,7 +13746,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000798 "Note that gamma-delta T cells h
AnnotationAssertion(rdfs:label obo:CL_0000798 "gamma-delta T cell")
EquivalentClasses(obo:CL_0000798 ObjectIntersectionOf(obo:CL_0000084 ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0042106)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000798 obo:CL_0000084)
-SubClassOf(obo:CL_0000798 obo:PR_000050567)
SubClassOf(obo:CL_0000798 ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0042106))
# Class: obo:CL_0000799 (immature gamma-delta T cell)
@@ -13583,7 +13839,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000805 "Note that this type of thymocyt
AnnotationAssertion(rdfs:label obo:CL_0000805 "immature single positive thymocyte")
EquivalentClasses(obo:CL_0000805 ObjectIntersectionOf(obo:CL_0000893 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001307) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001380) ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0043384) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000025402) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001932)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000805 obo:CL_0000893)
-SubClassOf(obo:CL_0000805 obo:PR_000050567)
SubClassOf(obo:CL_0000805 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004))
SubClassOf(obo:CL_0000805 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001307))
SubClassOf(obo:CL_0000805 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001380))
@@ -13608,7 +13863,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000806 "Note that this type of thymocyt
AnnotationAssertion(rdfs:label obo:CL_0000806 "DN2 thymocyte")
EquivalentClasses(obo:CL_0000806 ObjectIntersectionOf(obo:CL_0000893 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000025402) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001307) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001380)))
SubClassOf(obo:CL_0000806 obo:CL_0002489)
-SubClassOf(obo:CL_0000806 obo:PR_000050567)
SubClassOf(obo:CL_0000806 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001307))
SubClassOf(obo:CL_0000806 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001380))
SubClassOf(obo:CL_0000806 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000894))
@@ -13631,7 +13885,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000807 "There is growing evidence that
AnnotationAssertion(rdfs:label obo:CL_0000807 "DN3 thymocyte")
EquivalentClasses(obo:CL_0000807 ObjectIntersectionOf(obo:CL_0000893 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001307) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000025402) ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0043384) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001380)))
SubClassOf(obo:CL_0000807 obo:CL_0002489)
-SubClassOf(obo:CL_0000807 obo:PR_000050567)
SubClassOf(obo:CL_0000807 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001307))
SubClassOf(obo:CL_0000807 ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0043384))
SubClassOf(obo:CL_0000807 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001380))
@@ -13653,7 +13906,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000808 "Note that this type of thymocyt
AnnotationAssertion(rdfs:label obo:CL_0000808 "DN4 thymocyte")
EquivalentClasses(obo:CL_0000808 ObjectIntersectionOf(obo:CL_0000893 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001307) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001380) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000025402) ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0043384)))
SubClassOf(obo:CL_0000808 obo:CL_0002489)
-SubClassOf(obo:CL_0000808 obo:PR_000050567)
SubClassOf(obo:CL_0000808 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001307))
SubClassOf(obo:CL_0000808 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001380))
SubClassOf(obo:CL_0000808 ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0043384))
@@ -13965,7 +14217,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000825 "Most markers only described for
AnnotationAssertion(rdfs:label obo:CL_0000825 "pro-NK cell")
EquivalentClasses(obo:CL_0000825 ObjectIntersectionOf(obo:CL_0000838 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001874) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002065) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001015) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001381) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001898)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000825 obo:CL_0000838)
-SubClassOf(obo:CL_0000825 obo:PR_000050567)
SubClassOf(obo:CL_0000825 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001874))
SubClassOf(obo:CL_0000825 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002065))
SubClassOf(obo:CL_0000825 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003))
@@ -13995,7 +14246,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000826 "Human pro-B cells are reportedl
AnnotationAssertion(rdfs:label obo:CL_0000826 "pro-B cell")
EquivalentClasses(obo:CL_0000826 ObjectIntersectionOf(obo:CL_0000838 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001903) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000006611) ObjectSomeValuesFrom(obo:RO_0000056 obo:GO_0033152)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000826 obo:CL_0000838)
-SubClassOf(obo:CL_0000826 obo:PR_000050567)
SubClassOf(obo:CL_0000826 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001903))
SubClassOf(obo:CL_0000826 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000006611))
SubClassOf(obo:CL_0000826 ObjectSomeValuesFrom(obo:RO_0000056 obo:GO_0033152))
@@ -14061,7 +14311,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000831 "mast cell progenitor")
EquivalentClasses(obo:CL_0000831 ObjectIntersectionOf(obo:CL_0000839 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007857) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007858) ObjectSomeValuesFrom(obo:CL_4030045 obo:PR_000005307) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001083) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001839) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001889) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001963) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002978) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002979) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002980) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002981) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000005178) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000016401) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0060374) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000009143) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000002065) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000007431)))
SubClassOf(obo:CL_0000831 obo:CL_0000763)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000831 obo:CL_0000839)
-SubClassOf(obo:CL_0000831 obo:PR_000050567)
SubClassOf(obo:CL_0000831 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007857))
SubClassOf(obo:CL_0000831 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007858))
SubClassOf(obo:CL_0000831 ObjectSomeValuesFrom(obo:CL_4030045 obo:PR_000005307))
@@ -14148,7 +14397,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000836 "promyelocyte")
EquivalentClasses(obo:CL_0000836 ObjectIntersectionOf(obo:CL_0000839 ObjectSomeValuesFrom(obo:BFO_0000051 obo:CL_0017503) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005730) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0042582) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001483) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001932) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0040072) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001456) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001892)))
SubClassOf(obo:CL_0000836 obo:CL_0000763)
SubClassOf(obo:CL_0000836 obo:CL_0002191)
-SubClassOf(obo:CL_0000836 obo:PR_000050567)
SubClassOf(obo:CL_0000836 ObjectSomeValuesFrom(obo:BFO_0000051 obo:CL_0017503))
SubClassOf(obo:CL_0000836 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005730))
SubClassOf(obo:CL_0000836 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0042582))
@@ -14178,7 +14426,6 @@ EquivalentClasses(obo:CL_0000837 ObjectIntersectionOf(obo:CL_0000988 ObjectSomeV
SubClassOf(obo:CL_0000837 obo:BFO_0000002)
SubClassOf(obo:CL_0000837 obo:CL_0000255)
SubClassOf(obo:CL_0000837 obo:CL_0008001)
-SubClassOf(obo:CL_0000837 obo:PR_000050567)
SubClassOf(obo:CL_0000837 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002))
SubClassOf(obo:CL_0000837 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004))
SubClassOf(obo:CL_0000837 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012))
@@ -14493,7 +14740,7 @@ AnnotationAssertion(owl:deprecated obo:CL_0000859 "true"^^xsd:boolean)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:add") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMID:16322748") Annotation(oboInOwl:hasDbXref "PMID:18303997") Annotation(oboInOwl:hasDbXref "PMID:20628149") Annotation(oboInOwl:hasDbXref "PMID:20870168") obo:IAO_0000115 obo:CL_0000860 "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000860 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri.2017.28") Annotation(oboInOwl:hasDbXref "DOI:10.1111/sji.12883") Annotation(oboInOwl:hasDbXref "DOI:10.1182/blood-2009-07-235028") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2015.00423/full") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2019.02035") terms:description obo:CL_0000860 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri.2017.28") Annotation(oboInOwl:hasDbXref "DOI:10.1111/sji.12883") Annotation(oboInOwl:hasDbXref "DOI:10.1182/blood-2009-07-235028") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2015.00423/full") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2019.02035") terms:description obo:CL_0000860 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Classical monocytes are a subtype of monocytes that are characterized by high CD14 but no CD16 expression. Emerging from the bone marrow and entering the bloodstream, these cells play central roles in immune responses and regulation of inflammation. CD14-positive CD16-negative monocytes form the majority of circulating monocytes in the body, typically contributing to around 80-90% of the total monocyte pool.
The primary function of the classical monocytes is to serve in the frontline of host defense against infections. They are primed to migrate to sites of infection, and they express pattern recognition receptors that help them identify and phagocytose pathogens, leading to their destruction. Classical monocytes also contribute to inflammation by producing several pro-inflammatory cytokines including interleukins and tumor necrosis factors.
@@ -14506,7 +14753,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000860 "Markers: CCR2+CXCCR1 (huma
AnnotationAssertion(rdfs:label obo:CL_0000860 "classical monocyte")
EquivalentClasses(obo:CL_0000860 ObjectIntersectionOf(obo:CL_0000576 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002548) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0006909) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0006954) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001199)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000860 obo:CL_0000576)
-SubClassOf(obo:CL_0000860 obo:PR_000050567)
SubClassOf(obo:CL_0000860 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002))
SubClassOf(obo:CL_0000860 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020))
SubClassOf(obo:CL_0000860 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289))
@@ -14526,7 +14772,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000861 "Markers: CD11b+, CD68+; Mouse:
AnnotationAssertion(rdfs:label obo:CL_0000861 "elicited macrophage")
EquivalentClasses(obo:CL_0000861 ObjectIntersectionOf(obo:CL_0000235 ObjectSomeValuesFrom(obo:RO_0000056 obo:GO_0006954) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001813) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002064)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000861 obo:CL_0000235)
-SubClassOf(obo:CL_0000861 obo:PR_000050567)
SubClassOf(obo:CL_0000861 ObjectSomeValuesFrom(obo:RO_0000056 obo:GO_0006954))
SubClassOf(obo:CL_0000861 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001012))
SubClassOf(obo:CL_0000861 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001813))
@@ -14545,7 +14790,7 @@ SubClassOf(obo:CL_0000862 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050777))
# Class: obo:CL_0000863 (inflammatory macrophage)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:ana") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMID:19132917") obo:IAO_0000115 obo:CL_0000863 "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41392-023-01452-1") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s12935-021-02089-2") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2015.00263") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2020.583084") terms:description obo:CL_0000863 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41392-023-01452-1") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s12935-021-02089-2") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2015.00263") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2020.583084") terms:description obo:CL_0000863 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Inflammatory macrophages, also sometimes referred to as M1 or classically activated macrophages, play an important role in the inflammatory response. The M1/M2 classification is based upon macrophage polarization rather than macrophage location and refers to macrophage activation towards either a more inflammatory or more resolving phenotype, respectively, although the functional diversity of macrophages is more nuanced than such a dichotomy suggests.
Inflammatory macrophages are derived from monocytes recruited to a site of infection or injury. M1 macrophages are classically activated, typically by IFN-γ or lipopolysaccharide (LPS). Upon sensing signs of inflammation, they quickly respond by increasing their pro-inflammatory activity. They achieve this by producing a range of signaling molecules, such as nitric oxide, reactive oxygen species, and numerous cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1, -6 and -12. The release of these potent molecules helps to recruit other immune cells to the site, killing off pathogenic organisms and facilitation inflammation. At the same time, M1 macrophages can also present antigens to T cells, thereby helping to induce an adaptive immune response. Over time, these macrophages may transition in phenotype and function to help resolve the inflammation and promote tissue repair.
@@ -14556,14 +14801,14 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:28923980") oboInOwl:hasR
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000863 cl:cellxgene_subset)
AnnotationAssertion(rdfs:comment obo:CL_0000863 "Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response).")
AnnotationAssertion(rdfs:label obo:CL_0000863 "inflammatory macrophage")
-EquivalentClasses(obo:CL_0000863 ObjectIntersectionOf(obo:CL_0000861 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032611) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032635) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032640) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0042554) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0042742) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0051767)))
+EquivalentClasses(obo:CL_0000863 ObjectIntersectionOf(obo:CL_0000861 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032611) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032635) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032640) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0042554) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0042742) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0045428)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000863 obo:CL_0000861)
SubClassOf(obo:CL_0000863 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032611))
SubClassOf(obo:CL_0000863 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032635))
SubClassOf(obo:CL_0000863 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032640))
SubClassOf(obo:CL_0000863 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0042554))
SubClassOf(obo:CL_0000863 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0042742))
-SubClassOf(obo:CL_0000863 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0051767))
+SubClassOf(obo:CL_0000863 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0045428))
# Class: obo:CL_0000864 (tissue-resident macrophage)
@@ -14615,7 +14860,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000868 "Marker was observed on rat cell
AnnotationAssertion(rdfs:label obo:CL_0000868 "lymph node macrophage")
EquivalentClasses(obo:CL_0000868 ObjectIntersectionOf(obo:CL_0000867 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000029) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001931) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001813)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000868 obo:CL_0000867)
-SubClassOf(obo:CL_0000868 obo:PR_000050567)
SubClassOf(obo:CL_0000868 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000029))
SubClassOf(obo:CL_0000868 ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001931))
SubClassOf(obo:CL_0000868 ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001012))
@@ -14658,7 +14902,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000872 "Markers: Mouse: F4/80-, MARCO+,
AnnotationAssertion(rdfs:label obo:CL_0000872 "splenic marginal zone macrophage")
EquivalentClasses(obo:CL_0000872 ObjectIntersectionOf(obo:CL_0000871 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001251) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001806) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001884) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001885) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000006172)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000872 obo:CL_0000871)
-SubClassOf(obo:CL_0000872 obo:PR_000050567)
SubClassOf(obo:CL_0000872 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001251))
SubClassOf(obo:CL_0000872 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012))
SubClassOf(obo:CL_0000872 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001806))
@@ -14673,7 +14916,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000873 "Markers: Mouse: F4/80-, Dectin2
AnnotationAssertion(rdfs:label obo:CL_0000873 "splenic metallophillic macrophage")
EquivalentClasses(obo:CL_0000873 ObjectIntersectionOf(obo:CL_0000871 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001251) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001813) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001931) ObjectSomeValuesFrom(obo:RO_0002220 obo:UBERON_0001959) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001806)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000873 obo:CL_0000871)
-SubClassOf(obo:CL_0000873 obo:PR_000050567)
SubClassOf(obo:CL_0000873 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001251))
SubClassOf(obo:CL_0000873 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001813))
SubClassOf(obo:CL_0000873 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001931))
@@ -14689,7 +14931,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000874 "Markers: Mouse: F4/80+, CD68+,
AnnotationAssertion(rdfs:label obo:CL_0000874 "splenic red pulp macrophage")
EquivalentClasses(obo:CL_0000874 ObjectIntersectionOf(obo:CL_0000871 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001250) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001013) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001806) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001813) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002064) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002972) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0006955) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0034102) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001931)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000874 obo:CL_0000871)
-SubClassOf(obo:CL_0000874 obo:PR_000050567)
SubClassOf(obo:CL_0000874 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001250))
SubClassOf(obo:CL_0000874 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001013))
SubClassOf(obo:CL_0000874 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001806))
@@ -14712,7 +14953,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000875 "Markers: CCR2-CX3CCR1+ (human,
AnnotationAssertion(rdfs:label obo:CL_0000875 "non-classical monocyte")
EquivalentClasses(obo:CL_0000875 ObjectIntersectionOf(obo:CL_0000576 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0000587) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0031294) ObjectSomeValuesFrom(obo:RO_0002353 obo:GO_0030224) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001206)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000875 obo:CL_0000576)
-SubClassOf(obo:CL_0000875 obo:PR_000050567)
SubClassOf(obo:CL_0000875 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002))
SubClassOf(obo:CL_0000875 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020))
SubClassOf(obo:CL_0000875 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289))
@@ -14731,7 +14971,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000876 "Markers: Mouse: F4/80-, CD68+,
AnnotationAssertion(rdfs:label obo:CL_0000876 "splenic white pulp macrophage")
EquivalentClasses(obo:CL_0000876 ObjectIntersectionOf(obo:CL_0000871 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001959) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001813) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002064)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000876 obo:CL_0000871)
-SubClassOf(obo:CL_0000876 obo:PR_000050567)
SubClassOf(obo:CL_0000876 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001959))
SubClassOf(obo:CL_0000876 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001813))
SubClassOf(obo:CL_0000876 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002064))
@@ -14751,6 +14990,13 @@ SubClassOf(obo:CL_0000877 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0043277))
# Class: obo:CL_0000878 (central nervous system macrophage)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMID:16322748") obo:IAO_0000115 obo:CL_0000878 "A tissue-resident macrophage found in the central nervous system.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00281-013-0382-8") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.immuni.2022.10.005") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.tins.2021.07.002") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41583-019-0201-x") terms:description obo:CL_0000878 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Central Nervous System (CNS) macrophages represent an integral part of the brain's innate immune system. These immune cells play crucial roles in maintenance and regulation, homeostasis, and disease response, thereby helping in the overall cognitive functioning of an organism.
+There are different macrophage populations in the CNS, often classified into microglial cells, which reside in the parenchyma, and non-parenchymal macrophages at the interface between the brain and the periphery, including the perivascular spaces, the choroid plexus, and the meninges. CNS macrophages are derived from erythromyeloid progenitors in the yolk sac. CNS macrophages have distinct morphologies: Meningeal and perivascular macrophages have a more elongated shape than microglia, which are characterized by a small cell body with fine processes; in contrast, choroid plexus macrophages typically have a stellate shape.
+Microglia are the most abundant abundant mononuclear phagocytes and have been shown to play a number of physiological roles, including proinflammatory and anti-inflammatory functions, synaptic pruning and remodeling, and apoptotic cell removal through phagocytosis. Non-parenchymal CAMs primarily support the barrier function against external antigens. Meningeal macrophages have been shown to respond to peripheral microbial challenges and to protect the brain against fatal viral infection.
+CNS macrophages are also involved in the initiation and progression of many neurological diseases, such as Alzheimer's disease and Parkinson's disease as well as multiple sclerosis.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000878 "https://cellxgene.cziscience.com/cellguide/CL_0000878")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000878 "CNS macrophage")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000878 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000878 "central nervous system macrophage")
@@ -14767,6 +15013,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:28323268") oboInOwl:hasE
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33556248") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_0000879 "MM")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:38347231") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_0000879 "MnMΦ")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37232741") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_0000879 "sdΜΦ")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000879 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000879 "meningeal macrophage")
EquivalentClasses(obo:CL_0000879 ObjectIntersectionOf(obo:CL_4042003 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002360) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0005044)))
SubClassOf(obo:CL_0000879 obo:CL_4042003)
@@ -14791,7 +15038,6 @@ AnnotationAssertion(rdfs:label obo:CL_0000881 "perivascular macrophage")
EquivalentClasses(obo:CL_0000881 ObjectIntersectionOf(obo:CL_4042003 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001981) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001483) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001889) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001925)))
SubClassOf(obo:CL_0000881 obo:CL_4033054)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000881 obo:CL_4042003)
-SubClassOf(obo:CL_0000881 obo:PR_000050567)
SubClassOf(obo:CL_0000881 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001981))
SubClassOf(obo:CL_0000881 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001483))
SubClassOf(obo:CL_0000881 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001889))
@@ -14871,11 +15117,11 @@ SubClassOf(obo:CL_0000888 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0043277))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:add") Annotation(oboInOwl:hasDbXref "GOC:ana") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMID:16168663") Annotation(oboInOwl:hasDbXref "PMID:17016554") Annotation(oboInOwl:hasDbXref "PMID:17016559") obo:IAO_0000115 obo:CL_0000889 "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive.")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000889 cl:blood_and_immune_upper_slim)
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000889 cl:cellxgene_subset)
AnnotationAssertion(rdfs:comment obo:CL_0000889 "Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis.")
AnnotationAssertion(rdfs:label obo:CL_0000889 "myeloid suppressor cell")
EquivalentClasses(obo:CL_0000889 ObjectIntersectionOf(obo:CL_0000766 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0001501) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001006) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050777)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000889 obo:CL_0000766)
-SubClassOf(obo:CL_0000889 obo:PR_000050567)
SubClassOf(obo:CL_0000889 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0001501))
SubClassOf(obo:CL_0000889 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001006))
SubClassOf(obo:CL_0000889 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001012))
@@ -14884,7 +15130,7 @@ SubClassOf(obo:CL_0000889 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050777))
# Class: obo:CL_0000890 (alternatively activated macrophage)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:ana") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMID:20510870") obo:IAO_0000115 obo:CL_0000890 "An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41392-023-01452-1") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s12935-021-02089-2") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2015.00263") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2020.583084") terms:description obo:CL_0000890 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41392-023-01452-1") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s12935-021-02089-2") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2015.00263") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2020.583084") terms:description obo:CL_0000890 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Alternatively activated macrophages, also referred to as M2 macrophages, are immune cells originating from monocytes. The M1/M2 classification is based upon macrophage polarization rather than macrophage location and refers to macrophage activation towards either a more inflammatory or more resolving phenotype, respectively, although the functional diversity of macrophages is more nuanced than such a dichotomy suggests.
M2 macrophages cells are differentiated from their precursors generally in response to Th2 cytokines, such as interleukin-4 (IL-4), interleukin-10 (IL-10), and interleukin-13 (IL-13). Tissue-resident macrophages are also sometimes said to have an “M2-like” phenotype. M2 macrophages play key roles in immunoregulation and disease resolution.
@@ -14951,7 +15197,6 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0000894 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000894 "DN1 thymic pro-T cell")
EquivalentClasses(obo:CL_0000894 ObjectIntersectionOf(obo:CL_0000827 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002370) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001380) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001307)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000894 obo:CL_0000827)
-SubClassOf(obo:CL_0000894 obo:PR_000050567)
SubClassOf(obo:CL_0000894 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002370))
SubClassOf(obo:CL_0000894 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004))
SubClassOf(obo:CL_0000894 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084))
@@ -15361,6 +15606,7 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000917 "Tc1 T-cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000917 "Tc1 T-lymphocyte")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000917 "Th1 CD8-positive T cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000917 "Th1 non-TFH CD8-positive T cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000917 cl:cellxgene_subset)
AnnotationAssertion(rdfs:comment obo:CL_0000917 "This cell type is compatible with the HIPC Lyoplate markers for 'Tc1 CD8+ T cell', but its logical definition includes additional known characteristics of Tc1 T cells.")
AnnotationAssertion(rdfs:label obo:CL_0000917 "Tc1 cell")
EquivalentClasses(obo:CL_0000917 ObjectIntersectionOf(obo:CL_0000908 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001835) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000003463) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001202) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001207) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032609)))
@@ -15544,6 +15790,7 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000928 "activated CD4-negat
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000928 "activated CD4-negative, CD8-negative type I NK T-cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000928 "activated CD4-negative, CD8-negative type I NK T-lymphocyte")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000928 "activated CD4-negative, CD8-negative type I NKT cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000928 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0000928 "activated CD4-negative, CD8-negative type I NK T cell")
EquivalentClasses(obo:CL_0000928 ObjectIntersectionOf(obo:CL_0000921 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001343) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002369)))
SubClassOf(obo:CL_0000928 obo:CL_0000924)
@@ -15686,7 +15933,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000937 "These cells are also reportedly
AnnotationAssertion(rdfs:label obo:CL_0000937 "pre-natural killer cell")
EquivalentClasses(obo:CL_0000937 ObjectIntersectionOf(obo:CL_0000623 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001381) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002065)))
SubClassOf(obo:CL_0000937 obo:CL_0000623)
-SubClassOf(obo:CL_0000937 obo:PR_000050567)
SubClassOf(obo:CL_0000937 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003))
SubClassOf(obo:CL_0000937 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001381))
SubClassOf(obo:CL_0000937 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002065))
@@ -15705,7 +15951,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000938 "This cell type is compatible wi
AnnotationAssertion(rdfs:label obo:CL_0000938 "CD16-negative, CD56-bright natural killer cell, human")
EquivalentClasses(obo:CL_0000938 ObjectIntersectionOf(obo:CL_0000824 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001483) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002015) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001319) ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032609) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001024)))
SubClassOf(obo:CL_0000938 obo:CL_0000824)
-SubClassOf(obo:CL_0000938 obo:PR_000050567)
SubClassOf(obo:CL_0000938 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001483))
SubClassOf(obo:CL_0000938 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002015))
SubClassOf(obo:CL_0000938 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001319))
@@ -15728,7 +15973,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0000939 "This cell type is compatible wi
AnnotationAssertion(rdfs:label obo:CL_0000939 "CD16-positive, CD56-dim natural killer cell, human")
EquivalentClasses(obo:CL_0000939 ObjectIntersectionOf(obo:CL_0000824 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002015) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001483) ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0001816) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0042267) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001024)))
SubClassOf(obo:CL_0000939 obo:CL_0000824)
-SubClassOf(obo:CL_0000939 obo:PR_000050567)
SubClassOf(obo:CL_0000939 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002015))
SubClassOf(obo:CL_0000939 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001483))
SubClassOf(obo:CL_0000939 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606))
@@ -15810,6 +16054,7 @@ SubClassOf(obo:CL_0000944 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0045630))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:add") Annotation(oboInOwl:hasDbXref "GOC:rhs") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "ISBN:0781735149") obo:IAO_0000115 obo:CL_0000945 "A lymphocyte of B lineage with the commitment to express an immunoglobulin complex.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0000945 obo:NCBITaxon_9606)
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0000945 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0000945 core:human_reference_atlas)
AnnotationAssertion(rdfs:comment obo:CL_0000945 "Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex).")
AnnotationAssertion(rdfs:label obo:CL_0000945 "lymphocyte of B lineage")
@@ -16475,6 +16720,7 @@ AnnotationAssertion(rdfs:comment obo:CL_0000995 "Originally described in the den
AnnotationAssertion(rdfs:label obo:CL_0000995 "CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor")
EquivalentClasses(obo:CL_0000995 ObjectUnionOf(obo:CL_0001021 obo:CL_0001026))
SubClassOf(obo:CL_0000995 obo:CL_0001060)
+SubClassOf(obo:CL_0000995 obo:CL_0011026)
# Class: obo:CL_0000996 (mature CD11c-negative plasmacytoid dendritic cell)
@@ -16489,22 +16735,22 @@ SubClassOf(obo:CL_0000996 ObjectSomeValuesFrom(obo:RO_0015015 obo:GO_0042613))
SubClassOf(obo:CL_0000996 ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001412))
SubClassOf(obo:CL_0000996 ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001438))
-# Class: obo:CL_0000997 (immature CD8_alpha-negative CD11b-positive dendritic cell)
+# Class: obo:CL_0000997 (immature CD8-alpha-negative CD11b-positive dendritic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0000997 "Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0000997 "Immature CD8-alpha-negative CD11b-positive dendritic cell is a CD8-alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low.")
AnnotationAssertion(rdfs:comment obo:CL_0000997 "Originally described in the dendritic cell ontology (DC_CL:0000010)(PMID:19243617).")
-AnnotationAssertion(rdfs:label obo:CL_0000997 "immature CD8_alpha-negative CD11b-positive dendritic cell")
+AnnotationAssertion(rdfs:label obo:CL_0000997 "immature CD8-alpha-negative CD11b-positive dendritic cell")
EquivalentClasses(obo:CL_0000997 ObjectIntersectionOf(obo:CL_0000999 ObjectSomeValuesFrom(obo:RO_0015016 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001438)))
SubClassOf(obo:CL_0000997 obo:CL_0000840)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000997 obo:CL_0000999)
-# Class: obo:CL_0000998 (CD8_alpha-negative CD11b-negative dendritic cell)
+# Class: obo:CL_0000998 (CD8-alpha-negative CD11b-negative dendritic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0000998 "CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0000998 "CD8-alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8-alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000998 "DC.8-4-11b-")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000998 "triple negative dendritic cell")
AnnotationAssertion(rdfs:comment obo:CL_0000998 "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000011)(PMID:19243617).")
-AnnotationAssertion(rdfs:label obo:CL_0000998 "CD8_alpha-negative CD11b-negative dendritic cell")
+AnnotationAssertion(rdfs:label obo:CL_0000998 "CD8-alpha-negative CD11b-negative dendritic cell")
EquivalentClasses(obo:CL_0000998 ObjectIntersectionOf(obo:CL_0000990 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001026) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002474)))
SubClassOf(obo:CL_0000998 obo:CL_0000766)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000998 obo:CL_0000990)
@@ -16517,7 +16763,7 @@ SubClassOf(obo:CL_0000998 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002474))
# Class: obo:CL_0000999 (CD4-positive CD11b-positive dendritic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0000999 "CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0000999 "CD8-alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8-alpha-negative.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000999 "DC.4+")
AnnotationAssertion(rdfs:comment obo:CL_0000999 "Defined as having a disposition to secreting anti-inflammatory cytokines. These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000012)(PMID:19243617).")
AnnotationAssertion(rdfs:label obo:CL_0000999 "CD4-positive CD11b-positive dendritic cell")
@@ -16530,12 +16776,12 @@ SubClassOf(obo:CL_0000999 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001004))
SubClassOf(obo:CL_0000999 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002010))
SubClassOf(obo:CL_0000999 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050728))
-# Class: obo:CL_0001000 (CD8_alpha-positive CD11b-negative dendritic cell)
+# Class: obo:CL_0001000 (CD8-alpha-positive CD11b-negative dendritic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001000 "CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001000 "CD8-alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8-alpha-positive.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0001000 "DC.8+")
AnnotationAssertion(rdfs:comment obo:CL_0001000 "Cells are defined as having a disposition to secreting inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000013)(PMID:19243617).")
-AnnotationAssertion(rdfs:label obo:CL_0001000 "CD8_alpha-positive CD11b-negative dendritic cell")
+AnnotationAssertion(rdfs:label obo:CL_0001000 "CD8-alpha-positive CD11b-negative dendritic cell")
EquivalentClasses(obo:CL_0001000 ObjectIntersectionOf(obo:CL_0000990 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001026) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001084) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0001816) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0042590) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050729)))
SubClassOf(obo:CL_0001000 obo:CL_0000766)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001000 obo:CL_0000990)
@@ -16547,49 +16793,49 @@ SubClassOf(obo:CL_0001000 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002010))
SubClassOf(obo:CL_0001000 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0042590))
SubClassOf(obo:CL_0001000 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050729))
-# Class: obo:CL_0001001 (immature CD8_alpha-negative CD11b-negative dendritic cell)
+# Class: obo:CL_0001001 (immature CD8-alpha-negative CD11b-negative dendritic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001001 "Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001001 "Immature CD8-alpha-negative CD11b-negative dendritic cell is a CD8-alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low.")
AnnotationAssertion(rdfs:comment obo:CL_0001001 "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000014)(PMID:19243617).")
-AnnotationAssertion(rdfs:label obo:CL_0001001 "immature CD8_alpha-negative CD11b-negative dendritic cell")
+AnnotationAssertion(rdfs:label obo:CL_0001001 "immature CD8-alpha-negative CD11b-negative dendritic cell")
EquivalentClasses(obo:CL_0001001 ObjectIntersectionOf(obo:CL_0000998 ObjectSomeValuesFrom(obo:RO_0015016 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001438)))
SubClassOf(obo:CL_0001001 obo:CL_0000840)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001001 obo:CL_0000998)
-# Class: obo:CL_0001002 (mature CD8_alpha-negative CD11b-negative dendritic cell)
+# Class: obo:CL_0001002 (mature CD8-alpha-negative CD11b-negative dendritic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001002 "Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001002 "Mature CD8-alpha-negative CD11b-negative dendritic cell is a CD8-alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive.")
AnnotationAssertion(rdfs:comment obo:CL_0001002 "These markers are associated with mouse cells. Defined as having a disposition to secretion of anti-inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000015)(PMID:19243617).")
-AnnotationAssertion(rdfs:label obo:CL_0001002 "mature CD8_alpha-negative CD11b-negative dendritic cell")
+AnnotationAssertion(rdfs:label obo:CL_0001002 "mature CD8-alpha-negative CD11b-negative dendritic cell")
EquivalentClasses(obo:CL_0001002 ObjectIntersectionOf(obo:CL_0000998 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001310) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0001816) ObjectSomeValuesFrom(obo:RO_0015015 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001438)))
SubClassOf(obo:CL_0001002 obo:CL_0000841)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001002 obo:CL_0000998)
SubClassOf(obo:CL_0001002 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0001001))
-# Class: obo:CL_0001003 (mature CD8_alpha-negative CD11b-positive dendritic cell)
+# Class: obo:CL_0001003 (mature CD8-alpha-negative CD11b-positive dendritic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001003 "Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001003 "Mature CD8-alpha-negative CD11b-positive dendritic cell is a CD8-alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive.")
AnnotationAssertion(rdfs:comment obo:CL_0001003 "Originally described in the dendritic cell ontology (DC_CL:0000016)(PMID:19243617).")
-AnnotationAssertion(rdfs:label obo:CL_0001003 "mature CD8_alpha-negative CD11b-positive dendritic cell")
+AnnotationAssertion(rdfs:label obo:CL_0001003 "mature CD8-alpha-negative CD11b-positive dendritic cell")
EquivalentClasses(obo:CL_0001003 ObjectIntersectionOf(obo:CL_0000999 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001310) ObjectSomeValuesFrom(obo:RO_0015015 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001438)))
SubClassOf(obo:CL_0001003 obo:CL_0000841)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001003 obo:CL_0000999)
SubClassOf(obo:CL_0001003 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000997))
-# Class: obo:CL_0001004 (immature CD8_alpha-positive CD11b-negative dendritic cell)
+# Class: obo:CL_0001004 (immature CD8-alpha-positive CD11b-negative dendritic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001004 "Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001004 "Immature CD8-alpha-positive CD11b-negative dendritic cell is a CD8-alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low.")
AnnotationAssertion(rdfs:comment obo:CL_0001004 "Originally described in the dendritic cell ontology (DC_CL:0000017)(PMID:19243617).")
-AnnotationAssertion(rdfs:label obo:CL_0001004 "immature CD8_alpha-positive CD11b-negative dendritic cell")
+AnnotationAssertion(rdfs:label obo:CL_0001004 "immature CD8-alpha-positive CD11b-negative dendritic cell")
EquivalentClasses(obo:CL_0001004 ObjectIntersectionOf(obo:CL_0001000 ObjectSomeValuesFrom(obo:RO_0015016 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001438)))
SubClassOf(obo:CL_0001004 obo:CL_0000840)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001004 obo:CL_0001000)
-# Class: obo:CL_0001005 (mature CD8_alpha-positive CD11b-negative dendritic cell)
+# Class: obo:CL_0001005 (mature CD8-alpha-positive CD11b-negative dendritic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001005 "Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001005 "Mature CD8-alpha-positive CD11b-negative dendritic cell is a CD8-alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive.")
AnnotationAssertion(rdfs:comment obo:CL_0001005 "Originally described in the dendritic cell ontology (DC_CL:0000018)(PMID:19243617).")
-AnnotationAssertion(rdfs:label obo:CL_0001005 "mature CD8_alpha-positive CD11b-negative dendritic cell")
+AnnotationAssertion(rdfs:label obo:CL_0001005 "mature CD8-alpha-positive CD11b-negative dendritic cell")
EquivalentClasses(obo:CL_0001005 ObjectIntersectionOf(obo:CL_0001000 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001310) ObjectSomeValuesFrom(obo:RO_0015015 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001438)))
SubClassOf(obo:CL_0001005 obo:CL_0000841)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001005 obo:CL_0001000)
@@ -16630,7 +16876,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0001008 "Cell markers are associated wit
AnnotationAssertion(rdfs:label obo:CL_0001008 "Kit and Sca1-positive hematopoietic stem cell")
EquivalentClasses(obo:CL_0001008 ObjectIntersectionOf(obo:CL_0000037 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001014) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001308) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001839) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001869) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001896) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002977) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002981) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001833) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002065) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002979)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001008 obo:CL_0000037)
-SubClassOf(obo:CL_0001008 obo:PR_000050567)
SubClassOf(obo:CL_0001008 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001014))
SubClassOf(obo:CL_0001008 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001308))
SubClassOf(obo:CL_0001008 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001869))
@@ -16675,6 +16920,7 @@ AnnotationAssertion(rdfs:comment obo:CL_0001012 "Originally described in the den
AnnotationAssertion(rdfs:label obo:CL_0001012 "CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor")
EquivalentClasses(obo:CL_0001012 ObjectUnionOf(obo:CL_0000557 obo:CL_0001027))
SubClassOf(obo:CL_0001012 obo:CL_0001060)
+SubClassOf(obo:CL_0001012 obo:CL_0011026)
# Class: obo:CL_0001013 (mature interstitial dendritic cell)
@@ -16697,11 +16943,11 @@ SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001014 obo:CL_0000453
SubClassOf(obo:CL_0001014 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001447))
SubClassOf(obo:CL_0001014 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002025))
-# Class: obo:CL_0001015 (CD8_alpha-low Langerhans cell)
+# Class: obo:CL_0001015 (CD8-alpha-low Langerhans cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001015 "CD8_alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8_alpha-low.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001015 "CD8-alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8-alpha-low.")
AnnotationAssertion(rdfs:comment obo:CL_0001015 "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000027)(PMID:19243617). They are also CD205-high, CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD285-positive (TLR5), CD286-positive (TLR6), and CD289-positive (TLR9).")
-AnnotationAssertion(rdfs:label obo:CL_0001015 "CD8_alpha-low Langerhans cell")
+AnnotationAssertion(rdfs:label obo:CL_0001015 "CD8-alpha-low Langerhans cell")
EquivalentClasses(obo:CL_0001015 ObjectIntersectionOf(obo:CL_0000453 ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001026) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001084)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001015 obo:CL_0000453)
SubClassOf(obo:CL_0001015 ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001026))
@@ -16726,11 +16972,11 @@ SubClassOf(obo:CL_0001017 obo:CL_0000841)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001017 obo:CL_0001014)
SubClassOf(obo:CL_0001017 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0001016))
-# Class: obo:CL_0001018 (immature CD8_alpha-low Langerhans cell)
+# Class: obo:CL_0001018 (immature CD8-alpha-low Langerhans cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001018 "Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001018 "Immature CD8-alpha-low Langerhans cell is a CD8-alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low.")
AnnotationAssertion(rdfs:comment obo:CL_0001018 "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000030)(PMID:19243617).")
-AnnotationAssertion(rdfs:label obo:CL_0001018 "immature CD8_alpha-low Langerhans cell")
+AnnotationAssertion(rdfs:label obo:CL_0001018 "immature CD8-alpha-low Langerhans cell")
EquivalentClasses(obo:CL_0001018 ObjectIntersectionOf(obo:CL_0001015 ObjectSomeValuesFrom(obo:RO_0015016 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001438)))
SubClassOf(obo:CL_0001018 obo:CL_0000840)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001018 obo:CL_0001015)
@@ -16740,13 +16986,14 @@ SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001018 obo:CL_0001015
AnnotationAssertion(rdfs:comment obo:CL_0001019 "Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617).")
AnnotationAssertion(rdfs:label obo:CL_0001019 "CD115-positive monocyte OR common dendritic progenitor")
EquivalentClasses(obo:CL_0001019 ObjectUnionOf(obo:CL_0001022 obo:CL_0001029))
+SubClassOf(obo:CL_0001019 obo:CL_0000763)
SubClassOf(obo:CL_0001019 obo:CL_0002031)
-# Class: obo:CL_0001020 (mature CD8_alpha-low Langerhans cell)
+# Class: obo:CL_0001020 (mature CD8-alpha-low Langerhans cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001020 "Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001020 "Mature CD8-alpha-low Langerhans cell is a CD8-alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive.")
AnnotationAssertion(rdfs:comment obo:CL_0001020 "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000031)(PMID:19243617).")
-AnnotationAssertion(rdfs:label obo:CL_0001020 "mature CD8_alpha-low Langerhans cell")
+AnnotationAssertion(rdfs:label obo:CL_0001020 "mature CD8-alpha-low Langerhans cell")
EquivalentClasses(obo:CL_0001020 ObjectIntersectionOf(obo:CL_0001015 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001310) ObjectSomeValuesFrom(obo:RO_0015015 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001438)))
SubClassOf(obo:CL_0001020 obo:CL_0000841)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001020 obo:CL_0001015)
@@ -16763,7 +17010,6 @@ AnnotationAssertion(rdfs:label obo:CL_0001021 "CD34-positive, CD38-positive comm
EquivalentClasses(obo:CL_0001021 ObjectIntersectionOf(obo:CL_0000051 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001015) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001408) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001898)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001021 obo:CL_0000051)
SubClassOf(obo:CL_0001021 obo:CL_0000995)
-SubClassOf(obo:CL_0001021 obo:PR_000050567)
SubClassOf(obo:CL_0001021 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003))
SubClassOf(obo:CL_0001021 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001015))
SubClassOf(obo:CL_0001021 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001408))
@@ -16780,7 +17026,6 @@ EquivalentClasses(obo:CL_0001022 ObjectIntersectionOf(obo:CL_0000576 ObjectSomeV
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001022 obo:CL_0000576)
SubClassOf(obo:CL_0001022 obo:CL_0000839)
SubClassOf(obo:CL_0001022 obo:CL_0001019)
-SubClassOf(obo:CL_0001022 obo:PR_000050567)
SubClassOf(obo:CL_0001022 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001012))
SubClassOf(obo:CL_0001022 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002062))
SubClassOf(obo:CL_0001022 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002001))
@@ -16812,7 +17057,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0001024 "Cell markers are associated wit
AnnotationAssertion(rdfs:label obo:CL_0001024 "CD34-positive, CD38-negative hematopoietic stem cell")
EquivalentClasses(obo:CL_0001024 ObjectIntersectionOf(obo:CL_0000037 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001408) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001483) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001892) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001945) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001786) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001809) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001843)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001024 obo:CL_0000037)
-SubClassOf(obo:CL_0001024 obo:PR_000050567)
SubClassOf(obo:CL_0001024 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001408))
SubClassOf(obo:CL_0001024 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001483))
SubClassOf(obo:CL_0001024 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001892))
@@ -16833,7 +17077,6 @@ AnnotationAssertion(rdfs:label obo:CL_0001025 "Kit-positive, Sca1-positive commo
EquivalentClasses(obo:CL_0001025 ObjectIntersectionOf(obo:CL_0000051 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001014) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001869) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001963) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002001) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002037) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000002065) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000002979)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001025 obo:CL_0000051)
SubClassOf(obo:CL_0001025 obo:CL_0001030)
-SubClassOf(obo:CL_0001025 obo:PR_000050567)
SubClassOf(obo:CL_0001025 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001014))
SubClassOf(obo:CL_0001025 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001869))
SubClassOf(obo:CL_0001025 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001963))
@@ -16869,7 +17112,6 @@ AnnotationAssertion(rdfs:label obo:CL_0001027 "CD7-negative lymphoid progenitor
EquivalentClasses(obo:CL_0001027 ObjectIntersectionOf(obo:CL_0000051 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001015) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001836) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001027 obo:CL_0000051)
SubClassOf(obo:CL_0001027 obo:CL_0001012)
-SubClassOf(obo:CL_0001027 obo:PR_000050567)
SubClassOf(obo:CL_0001027 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001015))
SubClassOf(obo:CL_0001027 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001836))
SubClassOf(obo:CL_0001027 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003))
@@ -16883,7 +17125,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0001028 "These markers are associated wi
AnnotationAssertion(rdfs:label obo:CL_0001028 "CD7-positive lymphoid progenitor cell")
EquivalentClasses(obo:CL_0001028 ObjectIntersectionOf(obo:CL_0000051 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001015) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001836)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001028 obo:CL_0000051)
-SubClassOf(obo:CL_0001028 obo:PR_000050567)
SubClassOf(obo:CL_0001028 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001015))
SubClassOf(obo:CL_0001028 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003))
SubClassOf(obo:CL_0001028 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001836))
@@ -16899,9 +17140,7 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0001029 cl:cellxgene_subset)
AnnotationAssertion(rdfs:comment obo:CL_0001029 "Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617).")
AnnotationAssertion(rdfs:label obo:CL_0001029 "common dendritic progenitor")
EquivalentClasses(obo:CL_0001029 ObjectIntersectionOf(obo:CL_0002031 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001083) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001839) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001889) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002978) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002981) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002001) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002062) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000002065)))
-SubClassOf(obo:CL_0001029 obo:CL_0000763)
SubClassOf(obo:CL_0001029 obo:CL_0001019)
-SubClassOf(obo:CL_0001029 obo:PR_000050567)
SubClassOf(obo:CL_0001029 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002))
SubClassOf(obo:CL_0001029 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004))
SubClassOf(obo:CL_0001029 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012))
@@ -16925,6 +17164,7 @@ AnnotationAssertion(rdfs:comment obo:CL_0001030 "Originally described in the den
AnnotationAssertion(rdfs:label obo:CL_0001030 "CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor")
EquivalentClasses(obo:CL_0001030 ObjectUnionOf(obo:CL_0001023 obo:CL_0001025))
SubClassOf(obo:CL_0001030 obo:CL_0001060)
+SubClassOf(obo:CL_0001030 obo:CL_0011026)
# Class: obo:CL_0001031 (cerebellar granule cell)
@@ -16948,7 +17188,6 @@ AnnotationAssertion(rdfs:label obo:CL_0001032 "cortical granule cell")
EquivalentClasses(obo:CL_0001032 ObjectIntersectionOf(obo:CL_0000120 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000956)))
SubClassOf(obo:CL_0001032 obo:CL_0000120)
SubClassOf(obo:CL_0001032 obo:CL_0010012)
-SubClassOf(obo:CL_0001032 obo:CL_0012001)
# Class: obo:CL_0001033 (hippocampal granule cell)
@@ -16972,7 +17211,14 @@ SubClassOf(obo:CL_0001034 obo:CL_0000000)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:add") Annotation(oboInOwl:hasDbXref "GO_REF:0000034") obo:IAO_0000115 obo:CL_0001035 "A connective tissue cell found in bone.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0001035 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0001035 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00795-015-0099-y") Annotation(oboInOwl:hasDbXref "DOI:10.1007/s11914-012-0105-4") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.jot.2021.04.005") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41413-020-0099-y") terms:description obo:CL_0001035 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Bone cells, also known as osteocytes, form the building blocks of the skeletal system. They represent the most common type of bone cell, making up approximately 95% of the total bone cell population in mature adult bone tissue. Osteocytes are a stellate shape with numerous long, slender dendritic processes.
+The formation of bone is a complex process involving the action of osteoclasts - cells that break down and reabsorb old bone, followed by osteoblasts that rebuild the bone. Osteocytes serve as coordinators for these two types of bone cells to ensure a balance in the bone remodeling process, contributing to maintaining both bone strength and mineral homeostasis.
+The primary functions of osteocytes involve the creation, maintenance, and repair of bone tissue. They ensure that bone remodeling is performed by forming a network within the bone and communicating with other cells to help them respond to mechanical strain and damage.
+A remarkable aspect of osteocytes is their ability to perceive mechanical forces, translating them into biochemical signals that regulate bone remodeling and adaptation. Defects in osteocyte function, aside from other bone cells, have been associated with several bone disorders such as osteoporosis, renal osteodystrophy, and skeletal manifestations of diabetes.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0001035 "2011-11-16T04:28:16Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0001035 "https://cellxgene.cziscience.com/cellguide/CL_0001035")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0001035 cl:general_cell_types_upper_slim)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0001035 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0001035 "bone cell")
@@ -17204,7 +17450,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0001054 "This cell type is compatible wi
AnnotationAssertion(rdfs:label obo:CL_0001054 "CD14-positive monocyte")
EquivalentClasses(obo:CL_0001054 ObjectIntersectionOf(obo:CL_0000576 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001889)))
SubClassOf(obo:CL_0001054 obo:CL_0000576)
-SubClassOf(obo:CL_0001054 obo:PR_000050567)
SubClassOf(obo:CL_0001054 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002))
SubClassOf(obo:CL_0001054 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020))
SubClassOf(obo:CL_0001054 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289))
@@ -17278,7 +17523,6 @@ AnnotationAssertion(rdfs:label obo:CL_0001059 "common myeloid progenitor, CD34-p
EquivalentClasses(obo:CL_0001059 ObjectIntersectionOf(obo:CL_0000049 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001944) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000005307) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007857) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007858) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002573) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0043011)))
SubClassOf(obo:CL_0001059 obo:CL_0000049)
SubClassOf(obo:CL_0001059 obo:CL_0011026)
-SubClassOf(obo:CL_0001059 obo:PR_000050567)
SubClassOf(obo:CL_0001059 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001944))
SubClassOf(obo:CL_0001059 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000005307))
SubClassOf(obo:CL_0001059 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007857))
@@ -17400,7 +17644,6 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0001066 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0001066 "erythroid progenitor cell, mammalian")
EquivalentClasses(obo:CL_0001066 ObjectIntersectionOf(obo:CL_0000038 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001083) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001839) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001889) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002978) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001945) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0030218)))
SubClassOf(obo:CL_0001066 obo:CL_0000038)
-SubClassOf(obo:CL_0001066 obo:PR_000050567)
SubClassOf(obo:CL_0001066 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002))
SubClassOf(obo:CL_0001066 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004))
SubClassOf(obo:CL_0001066 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012))
@@ -17479,7 +17722,6 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0001071 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0001071 "group 3 innate lymphoid cell")
EquivalentClasses(obo:CL_0001071 ObjectIntersectionOf(obo:CL_0001065 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000003455)))
SubClassOf(obo:CL_0001071 obo:CL_0001065)
-SubClassOf(obo:CL_0001071 obo:PR_000050567)
SubClassOf(obo:CL_0001071 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000003455))
# Class: obo:CL_0001072 (CD34-negative, CD117-positive innate lymphoid cell, human)
@@ -17491,7 +17733,6 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0001072 "CD34-negative, CD11
AnnotationAssertion(rdfs:label obo:CL_0001072 "CD34-negative, CD117-positive innate lymphoid cell, human")
EquivalentClasses(obo:CL_0001072 ObjectIntersectionOf(obo:CL_0001065 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_P28906) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0001501) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P10721) ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606)))
SubClassOf(obo:CL_0001072 obo:CL_0001082)
-SubClassOf(obo:CL_0001072 obo:PR_000050567)
SubClassOf(obo:CL_0001072 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_P28906))
SubClassOf(obo:CL_0001072 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P10721))
SubClassOf(obo:CL_0001072 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606))
@@ -17516,7 +17757,6 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0001074 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0001074 "CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human")
EquivalentClasses(obo:CL_0001074 ObjectIntersectionOf(obo:CL_0001065 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0001501) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P10721) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P13591) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P28906) ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606)))
SubClassOf(obo:CL_0001074 obo:CL_0001082)
-SubClassOf(obo:CL_0001074 obo:PR_000050567)
SubClassOf(obo:CL_0001074 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P10721))
SubClassOf(obo:CL_0001074 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P13591))
SubClassOf(obo:CL_0001074 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P28906))
@@ -17549,7 +17789,6 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0001077 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0001077 "ILC1, human")
EquivalentClasses(obo:CL_0001077 ObjectIntersectionOf(obo:CL_0001068 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_Q9UL17) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P16871) ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606)))
SubClassOf(obo:CL_0001077 obo:CL_0001068)
-SubClassOf(obo:CL_0001077 obo:PR_000050567)
SubClassOf(obo:CL_0001077 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_Q9UL17))
SubClassOf(obo:CL_0001077 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P16871))
SubClassOf(obo:CL_0001077 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606))
@@ -17593,7 +17832,6 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0001081 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0001081 "group 2 innate lymphoid cell, human")
EquivalentClasses(obo:CL_0001081 ObjectIntersectionOf(obo:CL_0001069 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_P23771) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P01589) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P16871) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_Q12918) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_Q9Y5Y4) ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606)))
SubClassOf(obo:CL_0001081 obo:CL_0001069)
-SubClassOf(obo:CL_0001081 obo:PR_000050567)
SubClassOf(obo:CL_0001081 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_P23771))
SubClassOf(obo:CL_0001081 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P01589))
SubClassOf(obo:CL_0001081 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_P16871))
@@ -17640,7 +17878,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0001200 "Types of B lineage lymphocytes
AnnotationAssertion(rdfs:label obo:CL_0001200 "lymphocyte of B lineage, CD19-positive")
EquivalentClasses(obo:CL_0001200 ObjectIntersectionOf(obo:CL_0000945 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001002) ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_40674)))
SubClassOf(obo:CL_0001200 obo:CL_0000945)
-SubClassOf(obo:CL_0001200 obo:PR_000050567)
SubClassOf(obo:CL_0001200 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020))
SubClassOf(obo:CL_0001200 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001002))
SubClassOf(obo:CL_0001200 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_40674))
@@ -17802,7 +18039,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002005 "Markers are associated with hum
AnnotationAssertion(rdfs:label obo:CL_0002005 "CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell")
EquivalentClasses(obo:CL_0002005 ObjectIntersectionOf(obo:CL_0000050 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001015) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001865) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001408)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002005 obo:CL_0000050)
-SubClassOf(obo:CL_0002005 obo:PR_000050567)
SubClassOf(obo:CL_0002005 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001015))
SubClassOf(obo:CL_0002005 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001865))
SubClassOf(obo:CL_0002005 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003))
@@ -17817,7 +18053,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002006 "Markers are associated with mou
AnnotationAssertion(rdfs:label obo:CL_0002006 "Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell")
EquivalentClasses(obo:CL_0002006 ObjectIntersectionOf(obo:CL_0000050 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001003) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001479) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001843) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001869) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002979) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002065) ObjectSomeValuesFrom(obo:RO_0015016 obo:GO_0033001)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002006 obo:CL_0000050)
-SubClassOf(obo:CL_0002006 obo:PR_000050567)
SubClassOf(obo:CL_0002006 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001003))
SubClassOf(obo:CL_0002006 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001479))
SubClassOf(obo:CL_0002006 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001843))
@@ -17876,7 +18111,6 @@ AnnotationAssertion(rdfs:label obo:CL_0002010 "pre-conventional dendritic cell")
EquivalentClasses(obo:CL_0002010 ObjectIntersectionOf(obo:CL_0002031 ObjectSomeValuesFrom(obo:CL_4030046 obo:GO_0042613) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001083) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001289) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001839) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001889) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002978) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002981) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001013) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001968) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002001)))
SubClassOf(obo:CL_0002010 obo:CL_0000763)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002010 obo:CL_0002031)
-SubClassOf(obo:CL_0002010 obo:PR_000050567)
SubClassOf(obo:CL_0002010 ObjectSomeValuesFrom(obo:CL_4030046 obo:GO_0042613))
SubClassOf(obo:CL_0002010 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002))
SubClassOf(obo:CL_0002010 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004))
@@ -17905,7 +18139,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002011 "Markers are associated with mou
AnnotationAssertion(rdfs:label obo:CL_0002011 "Kit-positive macrophage dendritic cell progenitor")
EquivalentClasses(obo:CL_0002011 ObjectIntersectionOf(obo:CL_0002009 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001206) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002001) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002062) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000002065)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002011 obo:CL_0002009)
-SubClassOf(obo:CL_0002011 obo:PR_000050567)
SubClassOf(obo:CL_0002011 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001206))
SubClassOf(obo:CL_0002011 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002001))
SubClassOf(obo:CL_0002011 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002062))
@@ -17993,7 +18226,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002017 "Cell surface markers associated
AnnotationAssertion(rdfs:label obo:CL_0002017 "Kit-negative, Ly-76 high orthochromatophilic erythroblasts")
EquivalentClasses(obo:CL_0002017 ObjectIntersectionOf(obo:CL_0000552 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001869) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002065) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002979) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000002981) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001945)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002017 obo:CL_0000552)
-SubClassOf(obo:CL_0002017 obo:PR_000050567)
SubClassOf(obo:CL_0002017 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001869))
SubClassOf(obo:CL_0002017 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002065))
SubClassOf(obo:CL_0002017 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002979))
@@ -18010,7 +18242,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002018 "Markers associated with human c
AnnotationAssertion(rdfs:label obo:CL_0002018 "CD71-negative, GlyA-positive orthochromatic erythroblast")
EquivalentClasses(obo:CL_0002018 ObjectIntersectionOf(obo:CL_0000552 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001945) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001460)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002018 obo:CL_0000552)
-SubClassOf(obo:CL_0002018 obo:PR_000050567)
SubClassOf(obo:CL_0002018 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001945))
SubClassOf(obo:CL_0002018 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001460))
SubClassOf(obo:CL_0002018 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002016))
@@ -18048,7 +18279,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002021 "Marker is associated with human
AnnotationAssertion(rdfs:label obo:CL_0002021 "GlyA-positive erythrocyte")
EquivalentClasses(obo:CL_0002021 ObjectIntersectionOf(obo:CL_0000595 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001460)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002021 obo:CL_0000595)
-SubClassOf(obo:CL_0002021 obo:PR_000050567)
SubClassOf(obo:CL_0002021 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001460))
SubClassOf(obo:CL_0002021 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002020))
@@ -18061,7 +18291,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002022 "Marker is associated with mouse
AnnotationAssertion(rdfs:label obo:CL_0002022 "Ly-76 high positive erythrocyte")
EquivalentClasses(obo:CL_0002022 ObjectIntersectionOf(obo:CL_0000595 ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000002981)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002022 obo:CL_0000595)
-SubClassOf(obo:CL_0002022 obo:PR_000050567)
SubClassOf(obo:CL_0002022 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002019))
SubClassOf(obo:CL_0002022 ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000002981))
@@ -18074,7 +18303,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002023 "Markers are associated with hum
AnnotationAssertion(rdfs:label obo:CL_0002023 "CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell")
EquivalentClasses(obo:CL_0002023 ObjectIntersectionOf(obo:CL_0000553 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001907) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000009127)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002023 obo:CL_0000553)
-SubClassOf(obo:CL_0002023 obo:PR_000050567)
SubClassOf(obo:CL_0002023 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003))
SubClassOf(obo:CL_0002023 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001907))
SubClassOf(obo:CL_0002023 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000009127))
@@ -18089,7 +18317,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002024 "Markers are associated with mou
AnnotationAssertion(rdfs:label obo:CL_0002024 "Kit-positive megakaryocyte progenitor cell")
EquivalentClasses(obo:CL_0002024 ObjectIntersectionOf(obo:CL_0000553 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001833) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001869) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002979) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002065) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000005178) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001479) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001483)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002024 obo:CL_0000553)
-SubClassOf(obo:CL_0002024 obo:PR_000050567)
SubClassOf(obo:CL_0002024 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001833))
SubClassOf(obo:CL_0002024 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001869))
SubClassOf(obo:CL_0002024 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002979))
@@ -18108,7 +18335,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002025 "Markers are commonly associated
AnnotationAssertion(rdfs:label obo:CL_0002025 "CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell")
EquivalentClasses(obo:CL_0002025 ObjectIntersectionOf(obo:CL_0000553 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001907) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000009127)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002025 obo:CL_0000553)
-SubClassOf(obo:CL_0002025 obo:PR_000050567)
SubClassOf(obo:CL_0002025 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001907))
SubClassOf(obo:CL_0002025 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001003))
SubClassOf(obo:CL_0002025 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000009127))
@@ -18123,7 +18349,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002026 "Markers are commonly associated
AnnotationAssertion(rdfs:label obo:CL_0002026 "CD34-negative, CD41-positive, CD42-positive megakaryocyte cell")
EquivalentClasses(obo:CL_0002026 ObjectIntersectionOf(obo:CL_0000556 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001003) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001907) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000009127)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002026 obo:CL_0000556)
-SubClassOf(obo:CL_0002026 obo:PR_000050567)
SubClassOf(obo:CL_0002026 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001003))
SubClassOf(obo:CL_0002026 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001907))
SubClassOf(obo:CL_0002026 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000009127))
@@ -18138,7 +18363,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002027 "Markers are commonly associated
AnnotationAssertion(rdfs:label obo:CL_0002027 "CD9-positive, CD41-positive megakaryocyte cell")
EquivalentClasses(obo:CL_0002027 ObjectIntersectionOf(obo:CL_0000556 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000005178) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000009127)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002027 obo:CL_0000556)
-SubClassOf(obo:CL_0002027 obo:PR_000050567)
SubClassOf(obo:CL_0002027 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000005178))
SubClassOf(obo:CL_0002027 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000009127))
SubClassOf(obo:CL_0002027 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002024))
@@ -18155,7 +18379,6 @@ AnnotationAssertion(rdfs:label obo:CL_0002028 "basophil mast progenitor cell")
EquivalentClasses(obo:CL_0002028 ObjectIntersectionOf(obo:CL_0000839 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000005307) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007857) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007858) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000007431) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000016401) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001867) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0030221) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0060374)))
SubClassOf(obo:CL_0002028 obo:CL_0000763)
SubClassOf(obo:CL_0002028 obo:CL_0002191)
-SubClassOf(obo:CL_0002028 obo:PR_000050567)
SubClassOf(obo:CL_0002028 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000005307))
SubClassOf(obo:CL_0002028 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007857))
SubClassOf(obo:CL_0002028 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000007858))
@@ -18647,16 +18870,16 @@ SubClassOf(obo:CL_0002058 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002398))
SubClassOf(obo:CL_0002058 ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001199))
SubClassOf(obo:CL_0002058 ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000002980))
-# Class: obo:CL_0002059 (CD8alpha-positive thymic conventional dendritic cell)
+# Class: obo:CL_0002059 (CD8-alpha-positive thymic conventional dendritic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:19273629") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002059 "A conventional thymic dendritic cell that is CD8alpha-positive.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:19273629") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002059 "A conventional thymic dendritic cell that is CD8-alpha-positive.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002059 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002059 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002059 "2010-06-07T02:48:36Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002059 "CD8alpha-alpha-positive thymic conventional dendritic cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002059 "DC.8+.Th")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002059 core:human_reference_atlas)
-AnnotationAssertion(rdfs:label obo:CL_0002059 "CD8alpha-positive thymic conventional dendritic cell")
+AnnotationAssertion(rdfs:label obo:CL_0002059 "CD8-alpha-positive thymic conventional dendritic cell")
EquivalentClasses(obo:CL_0002059 ObjectIntersectionOf(obo:CL_0000941 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001084)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002059 obo:CL_0000941)
SubClassOf(obo:CL_0002059 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001084))
@@ -18708,10 +18931,12 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:29463737") Annotation(ob
AnnotationAssertion(Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_0002062 "ATI")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002062 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002062 core:human_reference_atlas)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_0002062 "The marker set AGER can identify the Human cell type pulmonary alveolar type 1 cell in the Lung with a confidence of 0.85 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_0002062 "pulmonary alveolar type 1 cell")
EquivalentClasses(obo:CL_0002062 ObjectIntersectionOf(obo:CL_0000322 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0007585)))
SubClassOf(obo:CL_0002062 obo:CL_0000322)
SubClassOf(obo:CL_0002062 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0007585))
+SubClassOf(obo:CL_0002062 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000008))
# Class: obo:CL_0002063 (pulmonary alveolar type 2 cell)
@@ -18738,19 +18963,22 @@ AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_0002063 "TII")
AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_0002063 "lung type II cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002063 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002063 core:human_reference_atlas)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_0002063 "The marker set SFTPA1 can identify the Human cell type pulmonary alveolar type 2 cell in the Lung with a confidence of 0.95 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_0002063 "pulmonary alveolar type 2 cell")
EquivalentClasses(obo:CL_0002063 ObjectIntersectionOf(obo:CL_0000322 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032940) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0043129)))
SubClassOf(obo:CL_0002063 obo:CL_0000157)
SubClassOf(obo:CL_0002063 obo:CL_0000322)
SubClassOf(obo:CL_0002063 obo:CL_1000272)
+SubClassOf(obo:CL_0002063 obo:CL_1100001)
SubClassOf(obo:CL_0002063 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_4040003))
+SubClassOf(obo:CL_0002063 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000009))
# Class: obo:CL_0002064 (pancreatic acinar cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") Annotation(oboInOwl:hasDbXref "PMID:20395539") Annotation(oboInOwl:hasDbXref "http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells") obo:IAO_0000115 obo:CL_0002064 "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002064 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002064 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/0165-6147(89)90192-2") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrgastro.2013.36") Annotation(oboInOwl:hasDbXref "DOI:10.1097/01.mog.0000239863.96833.c0") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK54134/") terms:description obo:CL_0002064 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/0165-6147(89)90192-2") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrgastro.2013.36") Annotation(oboInOwl:hasDbXref "DOI:10.1097/01.mog.0000239863.96833.c0") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK54134/") terms:description obo:CL_0002064 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Pancreatic acinar cells are the functional units of the exocrine pancreas. These cells are structurally arranged in small clusters - or acini - with a small central lumen, and their primary function is to produce and secrete enzymes that facilitate digestion of proteins, carbohydrates, and fats within the small intestine.
Some of the most important digestive enzymes synthesized by the pancreatic acinar cells include amylase, which digests carbohydrates, lipase, which breaks down fats, and several proteases such as trypsin and chymotrypsin which are vital for the digestion of proteins. Importantly, these enzymes are produced as proenzymes or zymogens to avoid autolysis, or the breakdown of the pancreas itself.
@@ -18795,7 +19023,7 @@ SubClassOf(obo:CL_0002066 obo:CL_0000165)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0412046911") obo:IAO_0000115 obo:CL_0002067 "An enteroendocrine cell that produces glucagon.")
AnnotationAssertion(terms:contributor obo:CL_0002067 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.diabres.2018.06.013") Annotation(oboInOwl:hasDbXref "DOI:10.1210/en.2016-1748") Annotation(oboInOwl:hasDbXref "DOI:10.2337/db15-1541") Annotation(oboInOwl:hasDbXref "DOI:10.2337/dbi19-0002") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2012.00349/full") terms:description obo:CL_0002067 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.diabres.2018.06.013") Annotation(oboInOwl:hasDbXref "DOI:10.1210/en.2016-1748") Annotation(oboInOwl:hasDbXref "DOI:10.2337/db15-1541") Annotation(oboInOwl:hasDbXref "DOI:10.2337/dbi19-0002") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2012.00349/full") terms:description obo:CL_0002067 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Type A enteroendocrine cells, also known as alpha cells or A cells, are a species of endocrine cells primarily located in the pancreatic islets of Langerhans; they have also been identified within the lining of the stomach. Functionally, these cells are pivotal in glucose metabolism and homeostasis, accounting for about 20% of the total population of cells in the pancreatic islets.
The primary role of type A enteroendocrine cells involves the synthesis, storage, and secretion of the peptide hormone glucagon, which is critical in energy regulation throughout the body. In response to a decrease in blood glucose levels, the pancreatic A cells are stimulated to secrete glucagon into the bloodstream. Glucagon acts on its target cells, mainly in the liver, to stimulate glycogenolysis and gluconeogenesis processes, thereby increasing blood glucose levels back to normal. In this way, pancreatic A cells play an integral role in maintaining glucose homeostasis and preventing hypoglycemia.
@@ -18804,6 +19032,7 @@ Until recently, glucagon has been considered a pancreas-specific hormone; howeve
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002067 "2010-09-10T10:48:54Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002067 "FMA:62939")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002067 "https://cellxgene.cziscience.com/cellguide/CL_0002067")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002067 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002067 "type A enteroendocrine cell")
EquivalentClasses(obo:CL_0002067 ObjectIntersectionOf(obo:CL_0000164 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0070091)))
SubClassOf(obo:CL_0002067 obo:CL_0000164)
@@ -18866,7 +19095,6 @@ AnnotationAssertion(rdfs:label obo:CL_0002071 "enterocyte of epithelium of large
EquivalentClasses(obo:CL_0002071 ObjectIntersectionOf(obo:CL_0000584 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001278)))
SubClassOf(obo:CL_0002071 obo:CL_0000584)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002071 obo:CL_0002253)
-SubClassOf(obo:CL_0002071 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001278))
# Class: obo:CL_0002072 (nodal myocyte)
@@ -18903,15 +19131,19 @@ SubClassOf(obo:CL_0002074 obo:CL_0002086)
# Class: obo:CL_0002075 (brush cell of tracheobronchial tree)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") Annotation(oboInOwl:hasDbXref "PMID:15817800") obo:IAO_0000115 obo:CL_0002075 "Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") Annotation(oboInOwl:hasDbXref "PMID:15817800") Annotation(oboInOwl:hasDbXref "PMID:30291131") Annotation(oboInOwl:hasDbXref "PMID:37925434") obo:IAO_0000115 obo:CL_0002075 "A rare type of columnar epithelial cell that is part of the tracheobronchial epithelium. This cell is characterized by a distinctive tuft of apical microvilli, which extends into the cytoplasm, and a pear-shaped morphology, broad at the base and tapering to a narrow apex. It plays vital roles in chemosensation, producing cytokines like IL-25, and enhancing mucociliary clearance through acetylcholine release to support mucus movement and airway defense.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_0002075 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002075 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002075 "2010-06-29T03:22:46Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_0002075 "pulmonary brush cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002075 cl:cellxgene_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_0002075 "The marker set POU2F3, HOMER3, MYB can identify the Human cell type brush cell of tracheobronchial tree in the Lung with a confidence of 0.56 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_0002075 "brush cell of tracheobronchial tree")
EquivalentClasses(obo:CL_0002075 ObjectIntersectionOf(obo:CL_0002204 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008397)))
+SubClassOf(obo:CL_0002075 obo:CL_0000075)
SubClassOf(obo:CL_0002075 obo:CL_0002202)
SubClassOf(obo:CL_0002075 obo:CL_0002204)
+SubClassOf(obo:CL_0002075 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000061))
# Class: obo:CL_0002076 (endo-epithelial cell)
@@ -18920,6 +19152,7 @@ AnnotationAssertion(terms:contributor obo:CL_0002076 ) oboInOwl:hasDbXref obo:CL_0002076 "ZFA:0009383")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002076 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002076 "endo-epithelial cell")
EquivalentClasses(obo:CL_0002076 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000223)))
SubClassOf(obo:CL_0002076 obo:BFO_0000002)
@@ -19097,7 +19330,6 @@ AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_0002089 "nuocyte")
AnnotationAssertion(rdfs:label obo:CL_0002089 "group 2 innate lymphoid cell, mouse")
EquivalentClasses(obo:CL_0002089 ObjectIntersectionOf(obo:CL_0001069 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001008) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001326) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001893) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001927) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000007431) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001860) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001869) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000008982) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000008994) ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_10090) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002830) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032616)))
SubClassOf(obo:CL_0002089 obo:CL_0001069)
-SubClassOf(obo:CL_0002089 obo:PR_000050567)
SubClassOf(obo:CL_0002089 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004))
SubClassOf(obo:CL_0002089 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001008))
SubClassOf(obo:CL_0002089 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012))
@@ -19225,8 +19457,13 @@ SubClassOf(obo:CL_0002097 obo:CL_1001601)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002098 "A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval.")
AnnotationAssertion(terms:contributor obo:CL_0002098 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2013.00102") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK572070") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164530") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/cardiac-muscle") terms:description obo:CL_0002098 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Cardiac myocytes, also known as cardiac muscle cells, form the majority of the cardiac tissue and are responsible for the contractile function of the heart. These myocytes are columnar-shaped cells with centrally located nuclei, and they exhibit visibly striated cytoplasm due to the organized array of myofibrils, which are composed of filaments of actin and myosin. Cardiac myocytes connect with each other through specialized structures called intercalated discs, facilitating electrical and mechanical continuity and enabling synchronous contraction of the heart. They also possess a high number of mitochondria to meet their high energy demand for continuous heartbeat action.
+Cardiac myocytes are capable of automaticity, meaning they have the unique ability to spontaneously and rhythmically generate their electrical impulses, a characteristic led by pacemaker cells. The electrical signals initiated and propagated in these cells are responsible for heartbeats. They also respond to the electrical signals transmitted by the autonomic nervous system and chemical signals like hormones. Thus, cardiac myocytes not only participate in maintaining the heart’s function but also play a role in modulating heart rate and strength of contraction in response to the body's changing needs. Consequently, malfunction of these cells leads to serious cardiac diseases such as heart failure and arrhythmias.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002098 "2010-08-23T11:33:10Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002098 "FMA:67967")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002098 "https://cellxgene.cziscience.com/cellguide/CL_0002098")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002098 "regular cardiac muscle cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002098 "regular cardiac muscle fiber")
AnnotationAssertion(rdfs:label obo:CL_0002098 "regular cardiac myocyte")
@@ -19239,6 +19476,7 @@ AnnotationAssertion(terms:contributor obo:CL_0002099 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.bbamcr.2015.11.025") Annotation(oboInOwl:hasDbXref "DOI:10.1111/pace.14107") Annotation(oboInOwl:hasDbXref "DOI:10.1172/JCI25417") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/cardiac-muscle") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/neuroscience/cardiac-action-potential") terms:description obo:CL_0002129 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Regular atrial cardiac myocytes, also known as atrial myocytes, are specialized muscle cells found in the atria – the upper chambers of the heart. They contract and relax during the heart's cycle, modulating the pumping of blood through the atria and into the ventricles. Additionally, endowed with inherent rhythmic electrical activity, atrial myocytes contribute significantly to the initiation and propagation of the heart’s electrical impulses.
+A distinguishing feature that separates atrial myocytes from other cardiac myocytes is their ability to synthesize and secrete atrial natriuretic peptide (ANP) in response to atrial stretch or dilatation. ANP acts as a potent vasodilator and diuretic, helping to maintain blood pressure and volume homeostasis. The phenomena of atrial stretch or distension, which triggers ANP release, is often in response to excess blood volume entering the heart, providing a mechanism at the cellular level which actively regulates systemic cardiovascular balance.
+Like all cardiac myocytes, atrial myocytes are embedded in a dense network of connective tissue that provides structural support. These cells are characterized by a single, centrally located nucleus, and overall, have a rod-like appearance with branching ends that connect with adjacent cells to form a continuous, synchronized ensemble. Their cytoplasm is abundant with mitochondria, reflecting the high energy demand associated with constant contraction and relaxation. At the ultrastructural level, atrial myocytes display striations due to the regular arrangement of actin and myosin proteins, which facilitate the contraction process essential for the heart's pump function.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002129 "2010-08-23T11:41:03Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002129 "FMA:83108")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002129 "https://cellxgene.cziscience.com/cellguide/CL_0002129")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:pr") oboInOwl:hasExactSynonym obo:CL_0002129 "atrial cardiac muscle cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002129 "atrial myocyte")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002129 "regular atrial cardiac muscle fiber")
@@ -19706,9 +19951,15 @@ SubClassOf(obo:CL_0002137 obo:CL_0002097)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:17846148") obo:IAO_0000115 obo:CL_0002138 "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002138 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002138 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.it.2022.10.010") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41577-020-0281-x") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2019.00036") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2020.00509/full") Annotation(oboInOwl:hasDbXref "DOI:10.3892/mco.2017.1356") terms:description obo:CL_0002138 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Endothelial cells of lymphatic vessels are specialized type of cells that form the interior lining of the lymphatic system, which primarily comprises the lymph vessels and nodes. These cells play a critical role in creating a barrier between the lymphatic system and the surrounding tissues. They are structurally different from the endothelial cells of the blood vessels due to the presence of anchoring filaments and lack of a continuous basement membrane, and have a unique phenotype marked by the expression of various cell-specific markers such as Prox-1, VEGFR-3, and LYVE-1.
+A significant function of these endothelial cells is to maintain the fluid balance within the body. They facilitate the uptake of excess interstitial fluid that collects in the body tissues, and ensure its transport back into the bloodstream via the lymphatic vessels. These cells also enable the absorption of fats and fat-soluble vitamins from the digestive system, and their subsequent transport in the form of chyle, a milky fluid, to the blood.
+Furthermore, endothelial cells of lymphatic vessels play a pivotal role in the body's immune response. They enable the passage of lymphocytes, that are crucial for the body's defense mechanism, from the tissues into the lymph where these cells are activated to fight against foreign bodies and infections. Also, they regulate inflammation reactions by controlling the migration of inflammatory cells, and are thus involved in pathological conditions with an inflammatory component. Lastly, these cells have been noted for their involvement in various disease states related to tissue edema, metastasis, and tumor growth, thus highlighting their importance in both health and disease states.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002138 "2010-08-24T02:05:28Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002138 "BTO:0004167")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002138 "FMA:68458")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002138 "https://cellxgene.cziscience.com/cellguide/CL_0002138")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002138 "LEC")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002138 "lymphatic endothelial cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002138 cl:cellxgene_subset)
@@ -19723,10 +19974,16 @@ SubClassOf(obo:CL_0002138 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0005022))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:dsd") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:12768659") obo:IAO_0000115 obo:CL_0002139 "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.")
AnnotationAssertion(terms:contributor obo:CL_0002139 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41569-022-00770-1") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s12872-015-0124-z") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2022.863265/full") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/medicine-and-dentistry/vascular-endothelial-cell") terms:description obo:CL_0002139 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Endothelial cells of the vascular tree, commonly referred to as vascular endothelial cells, line the entire circulatory system, from the heart to the smallest capillaries. These cells have a unique, flattened shape, and are tightly bound together, forming a thin layer known as the endothelium. The endothelium is responsible for maintaining the interior surface of blood vessels, and plays a critical role in ensuring the smooth flow of blood.
+Vascular endothelial cells act as a semi-permeable membrane, controlling the passage of materials and the transit of white blood cells into and out of the bloodstream. These cells are also involved in blood coagulation. When a blood vessel is damaged, endothelial cells promote clotting to prevent excessive bleeding and facilitate wound healing. Other functions include regulation of blood pressure and blood volume by releasing vasodilators and vasoconstrictors to either widen or constrict blood vessels, accordingly.
+Furthermore, the endothelial cells are crucial in the formation of new blood vessels, a process known as angiogenesis. This is particularly important in wound healing and the growth of new tissues during development or after injury. In the context of diseases such as cancer, angiogenesis helps facilitate tumor growth by providing nutrients and oxygen.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002139 "2010-08-24T02:06:40Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002139 "BTO:0001854")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002139 "CALOHA:TS-1106")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002139 "FMA:67755")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002139 "https://cellxgene.cziscience.com/cellguide/CL_0002139")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002139 "vascular endothelial cell")
AnnotationAssertion(oboInOwl:hasNarrowSynonym obo:CL_0002139 "cubodial endothelial cell of vascular tree")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002139 cl:cellxgene_subset)
@@ -19734,19 +19991,19 @@ AnnotationAssertion(rdfs:comment obo:CL_0002139 "These cells are reportedly CD31
AnnotationAssertion(rdfs:label obo:CL_0002139 "endothelial cell of vascular tree")
SubClassOf(obo:CL_0002139 obo:CL_0000115)
-# Class: obo:CL_0002140 (acinar cell of sebaceous gland)
+# Class: obo:CL_0002140 (skin sebocyte)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002140 "A sebum secreting cell of the skin that secretes sebum into the hair follicles.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:37205445") obo:IAO_0000115 obo:CL_0002140 "An acinar cell that is part of a skin sebaceous gland. This cell produces and secretes sebum into hair follicles.")
AnnotationAssertion(terms:contributor obo:CL_0002140 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002140 "2010-08-24T09:27:52Z"^^xsd:dateTime)
-AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_0002140 "sebocyte")
+AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_0002140 "acinar cell of sebaceous gland")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002140 "BTO:0004613")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002140 "FMA:70953")
-AnnotationAssertion(rdfs:label obo:CL_0002140 "acinar cell of sebaceous gland")
-EquivalentClasses(obo:CL_0002140 ObjectIntersectionOf(obo:CL_0000317 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003487)))
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002140 "acinar cell of skin sebaceous gland")
+AnnotationAssertion(rdfs:label obo:CL_0002140 "skin sebocyte")
+EquivalentClasses(obo:CL_0002140 ObjectIntersectionOf(obo:CL_0000622 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003487)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002140 obo:CL_0000317)
SubClassOf(obo:CL_0002140 obo:CL_0000622)
-SubClassOf(obo:CL_0002140 obo:CL_1000448)
SubClassOf(obo:CL_0002140 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003487))
# Class: obo:CL_0002141 (active chief cell of parathyroid gland)
@@ -19797,12 +20054,12 @@ SubClassOf(obo:CL_0002144 obo:CL_0002653)
SubClassOf(obo:CL_0002144 obo:CL_2000008)
SubClassOf(obo:CL_0002144 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001915))
-# Class: obo:CL_0002145 (ciliated columnar cell of tracheobronchial tree)
+# Class: obo:CL_0002145 (multiciliated columnar cell of tracheobronchial tree)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:28400610") obo:IAO_0000115 obo:CL_0002145 "A multi-ciliated epithelial cell located in the trachea and bronchi, characterized by a columnar shape and motile cilia on its apical surface. These cilia facilitate mucociliary clearance by moving mucus and trapped particles toward the pharynx.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002145 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002145 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1101/cshperspect.a028241") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-021014-071931") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajplung.00329.2019") Annotation(oboInOwl:hasDbXref "DOI:10.1159/000196486") terms:description obo:CL_0002145 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1101/cshperspect.a028241") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-021014-071931") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajplung.00329.2019") Annotation(oboInOwl:hasDbXref "DOI:10.1159/000196486") terms:description obo:CL_0002145 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Ciliated columnar cells of the tracheobronchial tree compose the inner lining of the tracheobronchial tree, the system of airways consisting of trachea, bronchi and bronchioles that allow passage of air into the lungs, where gas exchange occurs. A defining feature of these endo-epithelial cells are the tiny hair-like structures covering their surface, known as cilia. The nucleus is located at the base of the cell, and the area above it is rich in mitochondria and well-developed endoplasmic reticulum, both crucial for the energy-intensive process of cilia operation.
The primary function of these ciliated cells is to keep the respiratory tract clean via mucociliary clearance or the respiratory escalator. These cells create a two-layered 'coat': The lower \"sol\" layer is watery where the cilia can beat in coordinated waves, and the upper \"gel\" layer is thick and sticky, trapping inhaled particles, such as dust, bacteria, viruses, and other potentially harmful substances. This rhythmical beating of the cilia then moves the mucus and trapped particles upwards and out of the respiratory tract, which is then either coughed out or swallowed.
@@ -19810,14 +20067,17 @@ Damage or dysfunction of these ciliated cells, as seen in diseases such as prima
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002145 "2010-08-24T03:38:29Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002145 "FMA:70542")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002145 "https://cellxgene.cziscience.com/cellguide/CL_0002145")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002145 "ciliated columnar cell of tracheobronchial tree")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002145 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002145 core:human_reference_atlas)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_0002145 "The marker set C1orf194, MS4A8 can identify the Human cell type ciliated columnar cell of tracheobronchial tree in the Lung with a confidence of 0.86 (NS-Forest FBeta value).")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref ) Annotation(oboInOwl:hasDbXref "PMID:25386990") rdfs:comment obo:CL_0002145 "These cells possess numerous cilia on their surface, typically ranging from 200 to 300 per cell. The cilia vary in length, measuring between 6 to 7 μm in the upper airways (trachea) and becoming shorter, around 4 μm, in the smaller airways (terminal bronchioles). These cells form a two-layered 'coat' in the airway: the lower 'sol' layer is watery, allowing the cilia to beat in coordinated waves, while the upper 'gel' layer is thick and sticky, trapping inhaled particles.")
-AnnotationAssertion(rdfs:label obo:CL_0002145 "ciliated columnar cell of tracheobronchial tree")
+AnnotationAssertion(rdfs:label obo:CL_0002145 "multiciliated columnar cell of tracheobronchial tree")
+EquivalentClasses(obo:CL_0002145 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008397) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031514) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007)))
SubClassOf(obo:CL_0002145 obo:CL_0002202)
-SubClassOf(obo:CL_0002145 obo:CL_0005012)
SubClassOf(obo:CL_0002145 obo:CL_4030034)
SubClassOf(obo:CL_0002145 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002209))
+SubClassOf(obo:CL_0002145 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000041))
# Class: obo:CL_0002146 (clear cell of eccrine sweat gland)
@@ -19949,8 +20209,14 @@ AnnotationAssertion(owl:deprecated obo:CL_0002156 "true"^^xsd:boolean)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:0618947256") Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002157 "A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones.")
AnnotationAssertion(terms:contributor obo:CL_0002157 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/leu.2010.214") Annotation(oboInOwl:hasDbXref "DOI:10.1126/science.75570") Annotation(oboInOwl:hasDbXref "DOI:10.1182/blood-2004-06-2480") Annotation(oboInOwl:hasDbXref "DOI:10.1182/blood-2009-08-239194") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/engineering/endosteum") terms:description obo:CL_0002157 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Endosteal cells, also known as osteogenic cells, are a specialized type of cell that resides in the endosteum of the bone marrow cavity. The endosteum is a thin vascular membrane of connective tissue that lines the inner surface of the bony tissue that forms the medullary cavity of long bones. This specific location assigns endosteal cells critical roles in the bone maintenance and regeneration process as they actively participate in bone remodeling, a process that involves both the formation and resorption of bone tissue.
+Endosteal cells function by regulating the activity of both osteoblasts and osteoclasts. Osteoblasts are cells that deposit new bone, and osteoclasts are responsible for bone resorption, a process important for the maintenance, repair, and remodelling of bones. When new bone tissue is required, such as in instances of bone fractures or increased mechanical stress, endosteal cells differentiate into osteoblasts to facilitate the bone formation process. Conversely, when bone resorption is necessary, these cells are known to release signals that lead to the recruitment and activation of osteoclasts.
+In addition to this, endosteal cells play a significant role in hematopoiesis, which is the formation of blood cellular components. They function in this process by providing a niche for hematopoietic stem cells, serving to support their maintenance and differentiation. Understanding the functionality of endosteal cells is important in the field of regenerative medicine and stem cell therapy, especially in diseases affecting bone remodeling and hematopoiesis.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002157 "2010-08-24T03:33:58Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002157 "FMA:86495")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002157 "https://cellxgene.cziscience.com/cellguide/CL_0002157")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002157 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002157 "endosteal cell")
SubClassOf(obo:CL_0002157 obo:CL_0001035)
@@ -20038,7 +20304,6 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002166 "epithelial cell res
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002166 "epithelial debris of Malassez")
AnnotationAssertion(rdfs:label obo:CL_0002166 "epithelial cell of Malassez")
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002166 obo:CL_0002159)
-SubClassOf(obo:CL_0002166 obo:CL_0002251)
SubClassOf(obo:CL_0002166 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0011595))
# Class: obo:CL_0002167 (olfactory epithelial cell)
@@ -20047,6 +20312,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl
AnnotationAssertion(terms:contributor obo:CL_0002167 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002167 "2010-08-26T01:47:13Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002167 "FMA:67870")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002167 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002167 "olfactory epithelial cell")
EquivalentClasses(obo:CL_0002167 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050911)))
SubClassOf(obo:CL_0002167 obo:CL_0000098)
@@ -20085,7 +20351,6 @@ AnnotationAssertion(oboInOwl:creation_date obo:CL_0002170 "2010-08-26T02:51:30Z"
AnnotationAssertion(rdfs:label obo:CL_0002170 "keratinized cell of the oral mucosa")
EquivalentClasses(obo:CL_0002170 ObjectIntersectionOf(obo:CL_0000237 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003729)))
SubClassOf(obo:CL_0002170 obo:CL_0000237)
-SubClassOf(obo:CL_0002170 obo:CL_0002251)
SubClassOf(obo:CL_0002170 obo:CL_0002336)
SubClassOf(obo:CL_0002170 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003729))
@@ -20179,19 +20444,22 @@ AnnotationAssertion(terms:contributor obo:CL_0002178 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002179 "2010-08-25T03:23:22Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002179 "FMA:62949")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002179 "FMA:86552")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002179 "surface mucosal cell of stomach")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002179 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002179 "foveolar cell of stomach")
-SubClassOf(obo:CL_0002179 obo:CL_0002178)
+SubClassOf(obo:CL_0002179 obo:CL_0000075)
+SubClassOf(obo:CL_0002179 obo:CL_0002180)
# Class: obo:CL_0002180 (mucous cell of stomach)
@@ -20200,9 +20468,10 @@ AnnotationAssertion(terms:contributor obo:CL_0002180 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002182 "2010-08-25T03:45:10Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002182 "FMA:62949")
-AnnotationAssertion(rdfs:label obo:CL_0002182 "surface mucosal cell of stomach")
-SubClassOf(obo:CL_0002182 obo:CL_0000075)
-SubClassOf(obo:CL_0002182 obo:CL_0002180)
-SubClassOf(obo:CL_0002182 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001276))
+AnnotationAssertion(rdfs:comment obo:CL_0002182 "Duplicate with foveolar cell of stomach")
+AnnotationAssertion(rdfs:label obo:CL_0002182 "obsolete surface mucosal cell of stomach")
+AnnotationAssertion(owl:deprecated obo:CL_0002182 "true"^^xsd:boolean)
# Class: obo:CL_0002183 (stem cell of gastric gland)
@@ -20291,7 +20561,6 @@ AnnotationAssertion(rdfs:label obo:CL_0002188 "glomerular endothelial cell")
EquivalentClasses(obo:CL_0002188 ObjectIntersectionOf(obo:CL_0000115 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000074)))
SubClassOf(obo:CL_0002188 obo:CL_0000666)
SubClassOf(obo:CL_0002188 obo:CL_0002681)
-SubClassOf(obo:CL_0002188 obo:PR_000050567)
SubClassOf(obo:CL_0002188 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000074))
SubClassOf(obo:CL_0002188 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0036053))
@@ -20479,7 +20748,7 @@ SubClassOf(obo:CL_0002203 obo:CL_0019032)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") Annotation(oboInOwl:hasDbXref "PMID:15817800") obo:IAO_0000115 obo:CL_0002204 "A cell type found in the gastrointestinal and respiratory tracts that is characterized by the presence of a tuft of blunt, squat microvilli (120-140 per cell). Function of this cell type is not known.")
AnnotationAssertion(terms:contributor obo:CL_0002204 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/978-3-211-99390-3_83") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nature16161") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1469-7580.2005.00403.x") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2015.00087") Annotation(oboInOwl:hasDbXref "DOI:10.5114/ceji.2022.124416") terms:description obo:CL_0002204 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/978-3-211-99390-3_83") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nature16161") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1469-7580.2005.00403.x") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2015.00087") Annotation(oboInOwl:hasDbXref "DOI:10.5114/ceji.2022.124416") terms:description obo:CL_0002204 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Brush cells, also referred to as tuft cells or multivesicular cells, are a specialized type of epithelial cell mainly noted for their characteristic 'brush border' composed of microvilli. These cells reside in the epithelial lining of tissue organs such as the respiratory tract, gastrointestinal tract, and the bile ducts. The name derives from their distinct appearance under the microscope, which resembles a brush due to the dense layer of microvilli protruding into the lumen.
A key function of brush cells is chemosensation: They express a variety of signaling molecules and receptors that enable them to detect specific chemical stimuli in the environment and act as sensory transducers. Many of these receptors are responsive to luminal content, which makes brush cells vital for regulating and coordinating appropriate physiological responses to changes in these substances.
@@ -20712,8 +20981,14 @@ SubClassOf(obo:CL_0002222 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000096
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") obo:IAO_0000115 obo:CL_0002223 "A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s).")
AnnotationAssertion(terms:contributor obo:CL_0002223 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2007.10.034") Annotation(oboInOwl:hasDbXref "DOI:10.1111/aos.14600") Annotation(oboInOwl:hasDbXref "DOI:10.1155/2021/9951032") terms:description obo:CL_0002223 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+The anterior lens cells, also known as lens epithelial cells, are an integral part of the eye's structure and play a critical role in the organ's physiological functioning. They are situated in the anterior portion of the lens, precisely in the lens capsule, and stretch over the lens' frontal surface.
+The primary function of anterior lens cells is to facilitate eye accommodation by controlling the shape and thickness of the eye lens.
+The cells are involved in continuous proliferation, migration, and differentiation into lens fiber cells, helping to maintain lens growth and transparency. Anterior lens cells have a prolonged life span and reveal an extraordinary ability to function indefinitely, a characteristic that is critical for maintaining lens transparency. Damage or disturbance to the anterior lens cells can give rise to lens opacity, eventually leading to cataracts, which is a common cause of vision loss.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002223 "2010-09-07T10:45:45Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002223 "FMA:63181")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002223 "https://cellxgene.cziscience.com/cellguide/CL_0002223")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002223 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002223 "anterior lens cell")
SubClassOf(obo:CL_0002223 obo:CL_0002224)
@@ -20738,7 +21013,7 @@ SubClassOf(obo:CL_0002224 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000180
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") obo:IAO_0000115 obo:CL_0002225 "A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002225 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002225 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-1-4377-1926-0.10005-0") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2007.10.034") Annotation(oboInOwl:hasDbXref "DOI:10.1098/rstb.2010.0324") Annotation(oboInOwl:hasDbXref "DOI:10.1136/bmjophth-2020-000459") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/immunology-and-microbiology/lens-fiber") terms:description obo:CL_0002225 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-1-4377-1926-0.10005-0") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2007.10.034") Annotation(oboInOwl:hasDbXref "DOI:10.1098/rstb.2010.0324") Annotation(oboInOwl:hasDbXref "DOI:10.1136/bmjophth-2020-000459") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/immunology-and-microbiology/lens-fiber") terms:description obo:CL_0002225 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Secondary lens fibers are a specialized type of elongated cells located within the structure of the eye's lens. They play an essential role in vision by enabling light transmission and focus on the retina, which allows for clear, distinct vision. These cells are characterized by their lack of nuclei and organelles, their orderly alignment, and their high protein content, particularly crystallins.
Lens fibers are differentiated from equatorial epithelial cells of the lens in a process that involves cell elongation, denucleation and tight packing, which serve to reduce light scattering occurrences in the eye. This differentiation accelerates substantially after birth in comparison to during embryogenesis and continues throughout life, contributing to the growth of the eye lens. Secondary lens fibers are specifically those cells that are newly differentiated and cover the old lens fiber core. This process also leads to the removal of light-obstructing cellular components, mainly nuclei and organelles, making these fibers transparent and ideal for their function.
@@ -20931,22 +21206,25 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002240 "FMA:84377")
AnnotationAssertion(rdfs:label obo:CL_0002240 "marrow fibroblast")
EquivalentClasses(obo:CL_0002240 ObjectIntersectionOf(obo:CL_0000057 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002371)))
SubClassOf(obo:CL_0002240 obo:CL_0000057)
-SubClassOf(obo:CL_0002240 obo:CL_0002092)
+SubClassOf(obo:CL_0002240 obo:CL_0010001)
# Class: obo:CL_0002241 (pulmonary interstitial fibroblast)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002241 "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_0002241 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002241 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002241 "2010-09-07T02:29:38Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002241 "FMA:84467")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002241 "pulmonary myofibroblast")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002241 "pulmonary septal cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002241 cl:cellxgene_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_0002241 "The marker set DPT, APOD can identify the Human cell type pulmonary interstitial fibroblast in the Lung with a confidence of 0.58 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_0002241 "pulmonary interstitial fibroblast")
EquivalentClasses(obo:CL_0002241 ObjectIntersectionOf(obo:CL_0000057 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001004) ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005169)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002241 obo:CL_0000057)
SubClassOf(obo:CL_0002241 obo:CL_4030031)
SubClassOf(obo:CL_0002241 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001004))
+SubClassOf(obo:CL_0002241 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000046))
# Class: obo:CL_0002242 (nucleate cell)
@@ -20963,8 +21241,14 @@ SubClassOf(obo:CL_0002242 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0002505))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0721662544") Annotation(oboInOwl:hasDbXref "ISBN:0721694128") obo:IAO_0000115 obo:CL_0002243 "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells.")
AnnotationAssertion(terms:contributor obo:CL_0002243 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK532252/") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK537180/") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/neuroscience/iris-dilator-muscle") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/neuroscience/iris-sphincter-muscle") terms:description obo:CL_0002243 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+The smooth muscle cell of sphincter of pupil is a specialized cell type typically found within the eye, more specifically within the sphincter muscle of the iris.
+These cells can constrict and dilate in response to light signals, tightly regulating the amount of light reaching the retina. Contraction narrows the pupil in bright conditions (pupillary constriction), protecting the retina from excessive light. In low light, relaxation allows dilation (pupillary dilation), enhancing visual perception in dim conditions.
+These cells are also innervated by parasympathetic fibers from the oculomotor nerve. Light signals to the Edinger-Westphal nucleus stimulate the release of acetylcholine, contracting the cells. On the contrary, sympathetic stimulation induces relaxation. This precise control plays a crucial role in optimizing visual function, highlighting their essential role in vision biology.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002243 "2010-09-08T08:53:42Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002243 "FMA:70611")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002243 "https://cellxgene.cziscience.com/cellguide/CL_0002243")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002243 "smooth muscle fiber of sphincter of pupil")
AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_0002243 "smooth muscle fibre of sphincter of pupil")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002243 cl:cellxgene_subset)
@@ -21043,7 +21327,7 @@ SubClassOf(obo:CL_0002249 obo:CL_0002078)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") obo:IAO_0000115 obo:CL_0002250 "A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiates into columnar or goblet cells.")
AnnotationAssertion(terms:contributor obo:CL_0002250 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.cell.2013.07.004") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-018-0081-y") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41580-020-0278-0") Annotation(oboInOwl:hasDbXref "DOI:10.1101/gad.1674008") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1365-2184.2009.00642.x") terms:description obo:CL_0002250 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.cell.2013.07.004") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-018-0081-y") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41580-020-0278-0") Annotation(oboInOwl:hasDbXref "DOI:10.1101/gad.1674008") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1365-2184.2009.00642.x") terms:description obo:CL_0002250 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Intestinal crypt stem cells, also known as crypt base columnar cells, are a unique type of cell, characterized by the highly specific marker LGR5, found in the intestinal epithelium. Situated at the bottom of the minute pockets known as crypts of Lieberkühn, these are undifferentiated cells that have the ability to perpetually self-renew, as well as differentiate into various other cell types that constitute the epithelial lining of the intestine.
The fundamental role of intestinal crypt stem cells is to provide a constant supply of new cells to maintain the cellular turnover of the intestinal epithelium, a tissue known for rapid self-renewal. These stem cells are nurtured and protected by specialized epithelial and mesenchymal cells, and together constitute the intestinal stem cell niche.
@@ -21066,26 +21350,26 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl
AnnotationAssertion(terms:contributor obo:CL_0002251 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002251 "2010-09-08T09:26:53Z"^^xsd:dateTime)
AnnotationAssertion(rdfs:label obo:CL_0002251 "epithelial cell of alimentary canal")
-EquivalentClasses(obo:CL_0002251 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001555)))
+EquivalentClasses(obo:CL_0002251 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003929)))
SubClassOf(obo:CL_0002251 obo:CL_0002076)
-SubClassOf(obo:CL_0002251 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001555))
+SubClassOf(obo:CL_0002251 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003929))
# Class: obo:CL_0002252 (epithelial cell of esophagus)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002252 "An epithelial cell of the esophagus.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002252 "An epithelial cell of the lining of the esophagus.")
AnnotationAssertion(terms:contributor obo:CL_0002252 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002252 "2010-09-08T09:28:20Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002252 "FMA:63071")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0002252 "ZFA:0009400")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002252 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002252 "epithelial cell of esophagus")
-EquivalentClasses(obo:CL_0002252 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001043)))
+EquivalentClasses(obo:CL_0002252 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001976)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002252 obo:CL_0002251)
-SubClassOf(obo:CL_0002252 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001043))
+SubClassOf(obo:CL_0002252 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001976))
# Class: obo:CL_0002253 (epithelial cell of large intestine)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002253 "An epithelial cell of the large intestine.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002253 "An epithelial cell of the lining of the large intestine.")
AnnotationAssertion(terms:contributor obo:CL_0002253 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002253 "2010-09-08T09:28:22Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002253 "BTO:0004297")
@@ -21095,11 +21379,11 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0002253 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002253 "epithelial cell of large intestine")
EquivalentClasses(obo:CL_0002253 ObjectIntersectionOf(obo:CL_0002563 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000059)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002253 obo:CL_0002563)
-SubClassOf(obo:CL_0002253 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000059))
+SubClassOf(obo:CL_0002253 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001278))
# Class: obo:CL_0002254 (epithelial cell of small intestine)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002254 "An epithelial cell of the small intestine.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002254 "An epithelial cell of the lining of the small intestine.")
AnnotationAssertion(terms:contributor obo:CL_0002254 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002254 "2010-09-08T09:41:46Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002254 "FMA:256159")
@@ -21111,19 +21395,22 @@ SubClassOf(obo:CL_0002254 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000210
# Class: obo:CL_0002255 (stromal cell of endometrium)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:11331626") Annotation(oboInOwl:hasDbXref "PMID:30013421") Annotation(oboInOwl:hasDbXref "PMID:30309298") Annotation(oboInOwl:hasDbXref "Wiki:Decidualization&oldid=908981933#Endometrial_stromal_cells_(ESCs)") Annotation(oboInOwl:hasDbXref "https://doi.org/10.1038/s41591-020-1040-z") obo:IAO_0000115 obo:CL_0002255 "A stromal cell of the endometrium that is fibroblastic in appearance. During decidualization this cell may differentiate into a decidual stromal cell.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:11331626") Annotation(oboInOwl:hasDbXref "PMID:30013421") Annotation(oboInOwl:hasDbXref "PMID:30309298") Annotation(oboInOwl:hasDbXref "PMID:31907034") Annotation(oboInOwl:hasDbXref "Wikipedia:Decidualization") Annotation(oboInOwl:hasDbXref "https://doi.org/10.1038/s41591-020-1040-z") obo:IAO_0000115 obo:CL_0002255 "A stromal cell of the endometrium, characterized by its fibroblast-like morphology, regenerative capacity, and ability to undergo decidualization. It differentiates into a decidual stromal cell during pregnancy, essential for embryo implantation and maintenance. This cell is involved in tissue proliferation, remodeling, and breakdown, responding to hormonal changes, particularly estrogen and progesterone.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002255 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002255 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002255 "2010-09-08T09:50:04Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_0002255 "stromal cell of uterus")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002255 "CALOHA:TS-1266")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002255 "FMA:86490")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002255 "endometrial stromal cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30309298") oboInOwl:hasExactSynonym obo:CL_0002255 "endometrial stromal fibroblast")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002255 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002255 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0002255 "stromal cell of endometrium")
-EquivalentClasses(obo:CL_0002255 ObjectIntersectionOf(obo:CL_0000499 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001295)))
-SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002255 obo:CL_0000499)
+EquivalentClasses(obo:CL_0002255 ObjectIntersectionOf(obo:CL_0000499 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002337)))
+SubClassOf(obo:CL_0002255 obo:CL_0000499)
SubClassOf(obo:CL_0002255 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002337))
+SubClassOf(obo:CL_0002255 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0046697))
SubClassOf(obo:CL_0002255 ObjectSomeValuesFrom(obo:RO_0002388 obo:CL_2000002))
# Class: obo:CL_0002256 (supporting cell of carotid body)
@@ -21144,6 +21431,7 @@ AnnotationAssertion(terms:contributor obo:CL_0002257 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002260 "2010-09-08T02:29:38Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002260 "FMA:70547")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002260 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002260 "epithelial cell of parathyroid gland")
-EquivalentClasses(obo:CL_0002260 ObjectIntersectionOf(obo:CL_0002076 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001132)))
-SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002260 obo:CL_0002076)
-SubClassOf(obo:CL_0002260 obo:CL_1001593)
+EquivalentClasses(obo:CL_0002260 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001132)))
+SubClassOf(obo:CL_0002260 obo:CL_0002076)
+SubClassOf(obo:CL_0002260 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001132))
# Class: obo:CL_0002261 (endothelial cell of viscerocranial mucosa)
@@ -21201,8 +21490,14 @@ SubClassOf(obo:CL_0002261 obo:CL_0002076)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0618947256") obo:IAO_0000115 obo:CL_0002262 "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002262 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002262 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s10456-021-09780-y") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.jhep.2016.07.009") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-018-0020-y") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41598-020-57652-0") Annotation(oboInOwl:hasDbXref "DOI:10.1186/1476-5926-1-1") terms:description obo:CL_0002262 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Endothelial cells of sinusoids, often referred to as sinusoidal endothelial cells (SECs), are a specialized type of endothelial cell that primarily reside in the capillaries of the liver, spleen, and bone marrow. These cells form the innermost monolayer of the sinusoidal blood vessels, also known as sinusoids, that mediate the exchange of nutrients, metabolites, and waste materials between the blood and the surrounding organ tissue. SECs possess distinctive morphological features including a large, flattened shape, an abundance of fenestrations or pores, and the lack of a continuous basement membrane. These structural characteristics distinguish sinusoidal endothelial cells from other, more regularly structured endothelial cells in the body.
+Due to their special fenestrated structure, SECs facilitate the exchange of macromolecules, like lipoproteins and hyaluronan, between plasma and the surrounding organ parenchymal cells. These fenestrations act like sieves, allowing the passage of substances based on their size and charge. It's noteworthy that the permeability characteristics of SECs can be regulated dynamically according to the body's homeostatic needs.
+Beyond their key role in exchange mechanisms, endothelial cells of sinusoids are involved in several other functions. In the liver, for example, they help in the removal and endocytic degradation of waste macromolecules, immune response, and regulation of liver regeneration. They also participate in the formation and remodeling of blood vessels, a process known as angiogenesis. Additionally, in recent years, it has been discovered that these cells may have a role in disease conditions like cirrhosis and liver cancer.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002262 "2010-09-14T10:57:26Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002262 "FMA:63134")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002262 "https://cellxgene.cziscience.com/cellguide/CL_0002262")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002262 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002262 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0002262 "endothelial cell of sinusoid")
@@ -21226,9 +21521,9 @@ AnnotationAssertion(terms:contributor obo:CL_0002264 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-0-12-819402-7.00001-2") Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-012369442-3/50154-9") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.mce.2015.06.028") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s42255-019-0148-2") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fendo.2023.1192311") terms:description obo:CL_0002275 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-0-12-819402-7.00001-2") Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-012369442-3/50154-9") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.mce.2015.06.028") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s42255-019-0148-2") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fendo.2023.1192311") terms:description obo:CL_0002275 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Pancreatic polypeptide (PP) cells (also called F or gamma cells) are unique endocrine cells located within the Islets of Langerhans in the pancreas. PP cells are one of the rarer pancreatic cell types and are more prevalent in the head and neck of the pancreas. They are critical in normal pancreatic physiological functions and are involved in the development of pancreatic endocrine disorders.
The primary function of PP cells is the production and secretion of the pancreatic polypeptide hormone (PP). This hormone plays a crucial role in several gastrointestinal functions and metabolic responses. The release of the PP hormone is stimulated after eating, especially in protein-rich meals, leading to it being present in large amounts during digestion. The fundamental role of PP is to self-regulate pancreatic secretion activities ensuring its exocrine and endocrine functions are under control.
@@ -21690,7 +21987,7 @@ SubClassOf(Annotation(oboInOwl:hasDbXref "PMID:10770586") obo:CL_0002302 ObjectS
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:15106942") obo:IAO_0000115 obo:CL_0002303 "A cell that is part of pigmented ciliary epithelium. This cell type uptakes sodium and chloride ions from stromal interstitium and passes the ions to non-pigmented ciliary epithelial cells via gap junctions.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002303 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002303 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/S1569-2590(05)10005-6") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1444-0938.2002.tb02384.x") terms:description obo:CL_0002303 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/S1569-2590(05)10005-6") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1444-0938.2002.tb02384.x") terms:description obo:CL_0002303 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Pigmented ciliary epithelial cells, which are a type of pigment cell, have a crucial function within the eye's ciliary body. The ciliary body, located behind the iris, is one of the eye’s most vital structures and consists of two types of epithelial cells: the pigmented and the non-pigmented ciliary epithelial cells. The pigmented ciliary epithelial cells form the outer layer of the ciliary body and exhibit a black or brown pigmentation due to the melanin they contain.
One key function of pigmented ciliary epithelial cells is to aid in the formation of aqueous humor, an intraocular fluid that nourishes the cornea and lens, and maintains intraocular pressure which is essential for the eye’s shape and light refraction. These cells facilitate this function in conjunction with the non-pigmented ciliary epithelial cells. Together, the pigmented and non-pigmented ciliary epithelial cells form a bilayer epithelium that allows the secretion of aqueous humor through a bi-directional fluid transport mechanism.
@@ -21935,11 +22232,17 @@ SubClassOf(obo:CL_0002320 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000238
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:0618947256") obo:IAO_0000115 obo:CL_0002321 "A cell of the embryo.")
AnnotationAssertion(terms:contributor obo:CL_0002321 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/iub.1404") Annotation(oboInOwl:hasDbXref "DOI:10.1093/molehr/gan048") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK9906/") terms:description obo:CL_0002321 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Embryonic cells in metazoans, which include all multicellular animals, are biological units in their earliest developmental stages from conception until the organism is fully formed.
+They are derived from a fertilized egg, which undergoes a series of cell divisions to produce a multicellular organism. During the early phases of embryonic development, these cells exhibit pluripotency, meaning they possess the potential to differentiate into a diverse array of specialized cell types that constitute different body tissues and structures.
+The balance between cell proliferation and differentiation in embryonic cells is crucial for successful development. When cells continue to divide without differentiating, overgrowth may occur leading to conditions such as teratomas (tumors of embryonic cells). Conversely, if cell differentiation proceeds at the expense of cell proliferation, developmental anomalies could occur regarding size or mass of the organism or its parts.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002321 "2010-09-15T03:39:21Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002321 "CALOHA:TS-0263")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002321 "FMA:82840")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002321 "WBbt:0007028")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0002321 "ZFA:0007089")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002321 "https://cellxgene.cziscience.com/cellguide/CL_0002321")
AnnotationAssertion(rdfs:label obo:CL_0002321 "embryonic cell (metazoa)")
SubClassOf(obo:CL_0002321 obo:CL_0000000)
@@ -22065,7 +22368,7 @@ SubClassOf(obo:CL_0002328 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000203
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002329 "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002329 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002329 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1165/rcmb.2013-0049OC") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s12931-014-0160-8") Annotation(oboInOwl:hasDbXref "DOI:10.2353/ajpath.2010.090870") terms:description obo:CL_0002329 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1165/rcmb.2013-0049OC") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s12931-014-0160-8") Annotation(oboInOwl:hasDbXref "DOI:10.2353/ajpath.2010.090870") terms:description obo:CL_0002329 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
The basal epithelial cells of the tracheobronchial tree are critical components found in the lining of the airway passages, including the trachea and bronchi. They are keratin-5-positive, nonciliated, cuboidal cells and typically tightly attached to the basement membrane. In humans, the proportion of basal cells in the respiratory epithelium gradually decreases going down the tracheobronchial tree: they represent approximately 34% of the cells in the trachea, 27% in the large airways, and 10% in the small airways, although it is worth noting that there are differences in the compositions of the tracheobronchial epithelia between different species.
Basal epithelial cells serve as the basal layer of the tracheobronchial epithelium, providing both structural and regenerative support for the epithelial tissue that lines the upper regions of the respiratory tract. They serve as progenitor or stem cells that are capable of differentiating into multiple cell types, such as ciliated and secretory cells. This gives them a central role in homeostatic maintenance of the epithelium, and in repairing damaged epithelium after an injury or during disease. This regenerative capacity is crucial in maintaining the integrity of the tracheobronchial surface, especially given its continual exposure to inhaled irritants and microorganisms.
@@ -22091,16 +22394,17 @@ AnnotationAssertion(obo:IAO_0000231 obo:CL_0002331 obo:IAO_0000227)
AnnotationAssertion(obo:IAO_0100001 obo:CL_0002331 obo:CL_1000349)
AnnotationAssertion(owl:deprecated obo:CL_0002331 "true"^^xsd:boolean)
-# Class: obo:CL_0002332 (ciliated cell of the bronchus)
+# Class: obo:CL_0002332 (multiciliated epithelial cell of the bronchus)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:18757316") obo:IAO_0000115 obo:CL_0002332 "A ciliated cell of the bronchus.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:18757316") obo:IAO_0000115 obo:CL_0002332 "A multi-ciliated epithelial cell located in the bronchus epithelium, characterized by a columnar shape and motile cilia on its apical surface.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002332 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002332 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002332 "2010-09-20T02:21:12Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002332 "ciliated epithelial cell of the bronchus")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002332 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002332 core:human_reference_atlas)
-AnnotationAssertion(rdfs:label obo:CL_0002332 "ciliated cell of the bronchus")
-EquivalentClasses(obo:CL_0002332 ObjectIntersectionOf(obo:CL_0000064 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002031)))
+AnnotationAssertion(rdfs:label obo:CL_0002332 "multiciliated epithelial cell of the bronchus")
+EquivalentClasses(obo:CL_0002332 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002031) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031514) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007)))
SubClassOf(obo:CL_0002332 obo:CL_0002145)
SubClassOf(obo:CL_0002332 obo:CL_0002328)
@@ -22120,6 +22424,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl
AnnotationAssertion(terms:contributor obo:CL_0002334 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002334 "2010-09-20T02:31:53Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002334 "BTO:0001107")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002334 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002334 "preadipocyte")
SubClassOf(obo:CL_0002334 obo:CL_0000057)
@@ -22128,6 +22433,7 @@ SubClassOf(obo:CL_0002334 obo:CL_0000057)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:18719589") obo:IAO_0000115 obo:CL_0002335 "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha).")
AnnotationAssertion(terms:contributor obo:CL_0002335 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002335 "2010-09-20T02:38:38Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002335 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002335 "brown preadipocyte")
SubClassOf(obo:CL_0002335 obo:CL_0002334)
@@ -22164,7 +22470,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002338 "Human markers; killer cell immu
AnnotationAssertion(rdfs:label obo:CL_0002338 "CD56-positive, CD161-positive immature natural killer cell, human")
EquivalentClasses(obo:CL_0002338 ObjectIntersectionOf(obo:CL_0000823 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001003) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001024) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001381) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001874) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002065) ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606)))
SubClassOf(obo:CL_0002338 obo:CL_0000823)
-SubClassOf(obo:CL_0002338 obo:PR_000050567)
SubClassOf(obo:CL_0002338 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001003))
SubClassOf(obo:CL_0002338 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001024))
SubClassOf(obo:CL_0002338 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001381))
@@ -22226,8 +22531,10 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0002343 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002343 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0002343 "decidual natural killer cell, human")
EquivalentClasses(obo:CL_0002343 ObjectIntersectionOf(obo:CL_0000824 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001483) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000009766) ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001024)))
+SubClassOf(obo:CL_0002343 obo:CL_0000349)
SubClassOf(obo:CL_0002343 obo:CL_0000824)
-SubClassOf(obo:CL_0002343 obo:PR_000050567)
+SubClassOf(obo:CL_0002343 obo:CL_4052028)
+SubClassOf(obo:CL_0002343 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002450))
SubClassOf(obo:CL_0002343 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001483))
SubClassOf(obo:CL_0002343 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000009766))
SubClassOf(obo:CL_0002343 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606))
@@ -22243,7 +22550,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002344 "Human markers; killer cell immu
AnnotationAssertion(rdfs:label obo:CL_0002344 "CD56-negative, CD161-positive immature natural killer cell, human")
EquivalentClasses(obo:CL_0002344 ObjectIntersectionOf(obo:CL_0000823 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001003) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001381) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001874) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002065) ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606)))
SubClassOf(obo:CL_0002344 obo:CL_0000823)
-SubClassOf(obo:CL_0002344 obo:PR_000050567)
SubClassOf(obo:CL_0002344 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001003))
SubClassOf(obo:CL_0002344 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001024))
SubClassOf(obo:CL_0002344 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001381))
@@ -22261,7 +22567,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0002345 "Markers are associated with mou
AnnotationAssertion(rdfs:label obo:CL_0002345 "CD27-low, CD11b-low immature natural killer cell, mouse")
EquivalentClasses(obo:CL_0002345 ObjectIntersectionOf(obo:CL_0000823 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001008) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002977) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000009616) ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_10090) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001963)))
SubClassOf(obo:CL_0002345 obo:CL_0000823)
-SubClassOf(obo:CL_0002345 obo:PR_000050567)
SubClassOf(obo:CL_0002345 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001008))
SubClassOf(obo:CL_0002345 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002977))
SubClassOf(obo:CL_0002345 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000009616))
@@ -22278,7 +22583,6 @@ AnnotationAssertion(oboInOwl:creation_date obo:CL_0002346 "2010-09-21T10:11:44Z"
AnnotationAssertion(rdfs:label obo:CL_0002346 "Dx5-negative, NK1.1-positive immature natural killer cell, mouse")
EquivalentClasses(obo:CL_0002346 ObjectIntersectionOf(obo:CL_0000823 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001008) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002977) ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_10090)))
SubClassOf(obo:CL_0002346 obo:CL_0000823)
-SubClassOf(obo:CL_0002346 obo:PR_000050567)
SubClassOf(obo:CL_0002346 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001008))
SubClassOf(obo:CL_0002346 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002977))
SubClassOf(obo:CL_0002346 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_10090))
@@ -22291,7 +22595,6 @@ AnnotationAssertion(oboInOwl:creation_date obo:CL_0002347 "2010-09-21T10:19:49Z"
AnnotationAssertion(rdfs:label obo:CL_0002347 "CD27-high, CD11b-high natural killer cell, mouse")
EquivalentClasses(obo:CL_0002347 ObjectIntersectionOf(obo:CL_0000824 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_10090) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032609) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001963)))
SubClassOf(obo:CL_0002347 obo:CL_0000824)
-SubClassOf(obo:CL_0002347 obo:PR_000050567)
SubClassOf(obo:CL_0002347 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_10090))
SubClassOf(obo:CL_0002347 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002349))
SubClassOf(obo:CL_0002347 ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001012))
@@ -22305,7 +22608,6 @@ AnnotationAssertion(oboInOwl:creation_date obo:CL_0002348 "2010-09-21T10:19:54Z"
AnnotationAssertion(rdfs:label obo:CL_0002348 "CD27-low, CD11b-high natural killer cell, mouse")
EquivalentClasses(obo:CL_0002348 ObjectIntersectionOf(obo:CL_0000824 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_10090) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001963)))
SubClassOf(obo:CL_0002348 obo:CL_0000824)
-SubClassOf(obo:CL_0002348 obo:PR_000050567)
SubClassOf(obo:CL_0002348 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_10090))
SubClassOf(obo:CL_0002348 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002347))
SubClassOf(obo:CL_0002348 ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001012))
@@ -22319,7 +22621,6 @@ AnnotationAssertion(oboInOwl:creation_date obo:CL_0002349 "2010-09-21T10:20:00Z"
AnnotationAssertion(rdfs:label obo:CL_0002349 "CD27-high, CD11b-low natural killer cell, mouse")
EquivalentClasses(obo:CL_0002349 ObjectIntersectionOf(obo:CL_0000824 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_10090) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001963) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001012)))
SubClassOf(obo:CL_0002349 obo:CL_0000824)
-SubClassOf(obo:CL_0002349 obo:PR_000050567)
SubClassOf(obo:CL_0002349 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_10090))
SubClassOf(obo:CL_0002349 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002345))
SubClassOf(obo:CL_0002349 ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001963))
@@ -22330,8 +22631,14 @@ SubClassOf(obo:CL_0002349 ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001012))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISSN:0452-3458") obo:IAO_0000115 obo:CL_0002350 "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002350 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002350 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.medici.2017.08.003") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.ydbio.2009.06.033") Annotation(oboInOwl:hasDbXref "DOI:10.1101/cshperspect.a036723") Annotation(oboInOwl:hasDbXref "DOI:10.1161/ATVBAHA.121.313788") Annotation(oboInOwl:hasDbXref "DOI:10.1161/CIRCRESAHA.117.312136") terms:description obo:CL_0002350 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Endocardial cells, often referred to as endothelial cells of the heart, constitute the innermost lining layer of the heart tissues, forming the endocardium. They play a critical role in maintaining heart functionality and homeostasis. These cells, flat and squamous in structure, are adjoined closely to form a tight barrier that separates the heart's muscular layer, the myocardium, from the blood flowing through the heart chambers.
+Functionally, endocardial cells are key players in several crucial physiological processes within the heart. Synthesizing matrix molecules that contribute to the structural formation of the heart, these cells actively partake in maintaining its structural integrity. They also exhibit unique metabolic activity, which aids in maintaining optimal cardiac functioning in both healthy and pathological conditions. Importantly, they are known for their involvement in modulating myocardial contraction and relaxation, that is crucial for normal heart rhythm and function. They achieve this by producing factors like nitric oxide (NO) which, amongst other things, aids in the regulation of blood pressure, prevents blood clotting and inhibits the adherence of blood cells to the vessel wall.
+In pathological states, endocardial cells can undergo a transformation process known as endothelial-mesenchymal transition (EndMT), which is inherently involved in several cardiac diseases. In this transition, they acquire the ability to migrate and differentiate into several other types of cells contributing to disease progression. Moreover, their dysfunction can lead to endocarditis, an inflammation of the endocardium, as well as increase the risk of other heart diseases.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002350 "2010-09-21T04:33:05Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002350 "FMA:75621")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002350 "https://cellxgene.cziscience.com/cellguide/CL_0002350")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002350 "endocardial endothelial cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:75621") oboInOwl:hasExactSynonym obo:CL_0002350 "endothelial cell of endocardium")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002350 cl:cellxgene_subset)
@@ -22370,7 +22677,6 @@ AnnotationAssertion(oboInOwl:creation_date obo:CL_0002353 "2010-09-22T09:08:32Z"
AnnotationAssertion(rdfs:label obo:CL_0002353 "fetal liver hematopoietic progenitor cell")
EquivalentClasses(obo:CL_0002353 ObjectIntersectionOf(obo:CL_0002352 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001308) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001896) ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0042611) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001006) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001833) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001932) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002037) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002979)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002353 obo:CL_0002352)
-SubClassOf(obo:CL_0002353 obo:PR_000050567)
SubClassOf(obo:CL_0002353 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002107))
SubClassOf(obo:CL_0002353 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001308))
SubClassOf(obo:CL_0002353 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001896))
@@ -22390,7 +22696,6 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002354 "hemangioblast precu
AnnotationAssertion(rdfs:label obo:CL_0002354 "yolk sac hematopoietic stem cell")
EquivalentClasses(obo:CL_0002354 ObjectIntersectionOf(obo:CL_0002352 ObjectSomeValuesFrom(obo:CL_4030046 obo:GO_0042611) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001006) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002979) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001307) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001932) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002037)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002354 obo:CL_0002352)
-SubClassOf(obo:CL_0002354 obo:PR_000050567)
SubClassOf(obo:CL_0002354 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001040))
SubClassOf(obo:CL_0002354 ObjectSomeValuesFrom(obo:CL_4030046 obo:GO_0042611))
SubClassOf(obo:CL_0002354 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001006))
@@ -22411,7 +22716,6 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0002355 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002355 "primitive red blood cell")
EquivalentClasses(obo:CL_0002355 ObjectIntersectionOf(obo:CL_0002417 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000922) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000008467) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000008857) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0000586)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002355 obo:CL_0002417)
-SubClassOf(obo:CL_0002355 obo:PR_000050567)
SubClassOf(obo:CL_0002355 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000922))
SubClassOf(obo:CL_0002355 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000008467))
SubClassOf(obo:CL_0002355 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000008857))
@@ -22439,7 +22743,6 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002357 "macrocyte")
AnnotationAssertion(rdfs:label obo:CL_0002357 "fetal derived definitive erythrocyte")
EquivalentClasses(obo:CL_0002357 ObjectIntersectionOf(obo:CL_0000595 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000922) ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000008857)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002357 obo:CL_0000595)
-SubClassOf(obo:CL_0002357 obo:PR_000050567)
SubClassOf(obo:CL_0002357 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000922))
SubClassOf(obo:CL_0002357 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000008857))
SubClassOf(obo:CL_0002357 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002353))
@@ -22480,10 +22783,10 @@ AnnotationAssertion(terms:contributor obo:CL_0002361 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/bs.ai.2014.09.003") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri3667") Annotation(oboInOwl:hasDbXref "DOI:10.1111/sji.13094") terms:description obo:CL_0002364 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Cortical thymic epithelial cells (cTECs) are a vital cell type located in the thymus, a lymphoid organ that plays a key role in the development of T cells, which are essential for the adaptive immune system. cTECs also have a role in forming barriers and lining surfaces. In the thymus, their presence contributes to the distinctive architecture of both the cortex and medulla.
+cTECs also play a significant part in the selection and development of T cells. During T cell maturation, these cells express both self and non-self proteins via the major histocompatibility complex (MHC) to immature T cells. cTECs then stimulate the T cells that can recognize such proteins, an important event known as positive selection. This process aids in the creation of a diverse T cell receptor (TCR) repertoire that can react to a wide range of antigens, therefore ensuring effective immunity.
+Apart from aiding in T cells' positive selection, cTECs also contribute to eliminating self-reactive T cells, a role essential in preventing autoimmune diseases. These cells induce an apoptosis-driven process known as \"negative selection\" which eliminates T cells that are too highly reactive to self-antigens.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002364 "2010-09-23T03:17:12Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002364 "BTO:0004562")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002364 "https://cellxgene.cziscience.com/cellguide/CL_0002364")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002364 "cTEC")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002364 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002364 core:human_reference_atlas)
@@ -22535,8 +22845,14 @@ SubClassOf(obo:CL_0002364 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000212
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:18180458") obo:IAO_0000115 obo:CL_0002365 "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output.")
AnnotationAssertion(terms:contributor obo:CL_0002365 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s11427-013-4482-4") Annotation(oboInOwl:hasDbXref "DOI:10.4049/jimmunol.2100692") Annotation(oboInOwl:hasDbXref "DOI:10.7554/eLife.60188") terms:description obo:CL_0002365 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Medullary thymic epithelial cells (mTECs) are distinct cells situated in the thymic medulla, a vital organ where T cells mature. mTECs are recognized by their unique appearance, characterized by large, plump cells with abundant cytoplasm and irregularly shaped nuclei. They inhabit a microenvironment closely interacting with various thymic cell types, including conventional dendritic cells and thymocytes.
+The primary function of mTECs revolves around negative selection of developing T cells, thus preventing autoimmune responses. mTECs allow developing T cells to recognize and be responsive to foreign antigens while remaining tolerant to the body's own tissues. They achieve this through a process called promiscuous gene expression where they express and display a vast array of self-antigens. This process is regulated by a transcriptional regulator called autoimmune regulator (Aire), which contributes to immunological self-tolerance.
+mTECs themselves have a self-renewing ability and sustain the continuous export of mature T cells. They also express a number of genes that encode for chemokines and other signaling molecules which draw in and retain developing T cells for the process of negative selection. The three-dimensional network formed by these cells provides a physical platform for such selection. Together, mTECs hold a critical place in the maintenance of immune homeostasis, demonstrating the conceptual links that exist between population of stromal cells, thymocytes development, tissue-restricted antigen expression, and negative selection.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002365 "2010-09-23T03:17:14Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002365 "BTO:0004563")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002365 "https://cellxgene.cziscience.com/cellguide/CL_0002365")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002365 "mTEC")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002365 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002365 "medullary thymic epithelial cell")
@@ -22548,8 +22864,14 @@ SubClassOf(obo:CL_0002365 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000212
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:11429640") obo:IAO_0000115 obo:CL_0002366 "A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin.")
AnnotationAssertion(terms:contributor obo:CL_0002366 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1073/pnas.070447210") Annotation(oboInOwl:hasDbXref "DOI:10.1093/humupd/dmr031") Annotation(oboInOwl:hasDbXref "DOI:10.1177/1535370220938741") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/medicine-and-dentistry/uterine-contraction") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/myometrium") terms:description obo:CL_0002366 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Myometrial cells are specialized smooth muscle cells located in the myometrium, the middle layer of the uterine wall. Unique to female reproductive physiology, they play a key role in pregnancy and childbirth.
+These cells are distinctive in their capability to substantially increase in size and number during pregnancy, preparing the uterus to accommodate the growing fetus. As pregnancy progresses, myometrial cells demonstrate a progressive growth in uterine mass through cellular hypertrophy. They are also responsible for the production of extracellular matrix proteins like collagen, which aids in supporting cell structure and function, further facilitating uterine enlargement.
+During childbirth, myometrial cells are responsible for the expansion and contraction of the uterus. They can propagate action potentials and generate considerable force, which is critical to their function in the reproductive system. After pregnancy, these cells can reduce in size, a process known as uterine involution. Given the important role these cells play in female reproductive physiology, dysregulation of the myometrial cell function can contribute to uterine pathologies such as uterine fibroids.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002366 "2010-09-23T03:46:34Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002366 "BTO:0004519")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002366 "https://cellxgene.cziscience.com/cellguide/CL_0002366")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002366 "myometrium smooth muscle cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002366 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002366 "myometrial cell")
@@ -22568,15 +22890,16 @@ EquivalentClasses(obo:CL_0002367 ObjectIntersectionOf(obo:CL_0000115 ObjectSomeV
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002367 obo:CL_0000115)
SubClassOf(obo:CL_0002367 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005969))
-# Class: obo:CL_0002368 (respiratory epithelial cell)
+# Class: obo:CL_0002368 (respiratory tract epithelial cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002368 "An endo-epithelial cell of the respiratory tract.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002368 "An epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin.")
AnnotationAssertion(terms:contributor obo:CL_0002368 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002368 "2010-09-23T04:38:49Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002368 "BTO:0004533")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002368 "airway epithelial cell")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002368 "respiratory epithelial cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002368 cl:cellxgene_subset)
-AnnotationAssertion(rdfs:label obo:CL_0002368 "respiratory epithelial cell")
+AnnotationAssertion(rdfs:label obo:CL_0002368 "respiratory tract epithelial cell")
EquivalentClasses(obo:CL_0002368 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802)))
SubClassOf(obo:CL_0002368 obo:CL_0002076)
SubClassOf(obo:CL_0002368 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802))
@@ -22590,20 +22913,21 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002369 "MESH:D013172")
AnnotationAssertion(rdfs:label obo:CL_0002369 "fungal spore")
SubClassOf(obo:CL_0002369 obo:CL_0000521)
-# Class: obo:CL_0002370 (respiratory goblet cell)
+# Class: obo:CL_0002370 (respiratory tract goblet cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0721662544") obo:IAO_0000115 obo:CL_0002370 "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion.")
AnnotationAssertion(terms:contributor obo:CL_0002370 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/S1357-2725(02)00083-3") Annotation(oboInOwl:hasDbXref "DOI:10.1111/febs.15731") Annotation(oboInOwl:hasDbXref "DOI:10.1165/ajrcmb.25.5.f218") Annotation(oboInOwl:hasDbXref "DOI:10.2147/COPD.S38938") Annotation(oboInOwl:hasDbXref "DOI:10.3109/01902148.2013.791733") terms:description obo:CL_0002370 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/S1357-2725(02)00083-3") Annotation(oboInOwl:hasDbXref "DOI:10.1111/febs.15731") Annotation(oboInOwl:hasDbXref "DOI:10.1165/ajrcmb.25.5.f218") Annotation(oboInOwl:hasDbXref "DOI:10.2147/COPD.S38938") Annotation(oboInOwl:hasDbXref "DOI:10.3109/01902148.2013.791733") terms:description obo:CL_0002370 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
The respiratory goblet cell is a highly specialized cell type found primarily within the respiratory tract, including the nose, trachea, and lungs. Named because their shape resembles a goblet - a drinking vessel with a wide body and narrow neck - these cells form a vital part of the respiratory system's protective mechanisms. They are found within the columnar epithelium lining these organs, which forms a barrier between the internal body and the exterior environment.
A principal function of the respiratory goblet cell is the production and secretion of mucus, a carbohydrate-rich, viscous and gel-like substance that plays a critical role in trapping dust, bacteria, viruses, and other airborne particles that are inhaled. The mucus secreted by the goblet cells covers the lining of the respiratory tract, effectively catching these particles and preventing them from reaching the lungs and causing infection. Mucus also provides hydration and lubrication to the respiratory tract surfaces, which is important in maintaining the tissue's health and functioning.
In addition to their mucus-secreting capabilities, respiratory goblet cells also play a significant role in the body's inflammatory responses. When the respiratory system is exposed to irritants or pathogens, the number and activity of goblet cells often increase, leading to a higher production of mucus. This is a protective response designed to trap and neutralize the harmful substances more effectively. However, in conditions like chronic obstructive pulmonary disease (COPD) and asthma, an overproliferation of goblet cells, also known as goblet cell hyperplasia, can lead to excessive mucus production and airway obstruction.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002370 "2010-09-23T04:42:27Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002370 "https://cellxgene.cziscience.com/cellguide/CL_0002370")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002370 "respiratory goblet cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MP:0010863") oboInOwl:hasExactSynonym obo:CL_0002370 "respiratory mucosa goblet cells")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002370 cl:cellxgene_subset)
-AnnotationAssertion(rdfs:label obo:CL_0002370 "respiratory goblet cell")
+AnnotationAssertion(rdfs:label obo:CL_0002370 "respiratory tract goblet cell")
EquivalentClasses(obo:CL_0002370 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802)))
SubClassOf(obo:CL_0002370 obo:CL_0000160)
SubClassOf(obo:CL_0002370 obo:CL_0002368)
@@ -22614,11 +22938,17 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl
AnnotationAssertion(obo:IAO_0000233 obo:CL_0002371 )
AnnotationAssertion(obo:IAO_0100001 obo:CL_0002371 obo:CL_0000000)
AnnotationAssertion(terms:contributor obo:CL_0002371 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrm3980") Annotation(oboInOwl:hasDbXref "https://www.genome.gov/genetics-glossary/Somatic-Cells") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK557896/") terms:description obo:CL_0002371 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Somatic cells represent the majority of the cell types in the human body. They are fundamental building blocks of organs, tissues, and other bodily structures, with every organ being composed of distinct subpopulations of these cells.
+The primary function of somatic cells is to maintain the function and survival of an organism. They carry significant information in the form of DNA, and through the process of mitosis, contribute to the repair and regeneration of body tissues.
+Further, some types of somatic cells work in a collaborative manner to form complex functional structures such as the skin and lining of the gut, demonstrating a higher level of organization. However, it's important to note that somatic cells are distinct from germ cells, which are responsible for sexual reproduction by forming sperm or eggs. Any alterations in the DNA of somatic cells, due to mutations, will not affect the offspring as they aren't involved in transmission of genetic information to the next generation.
+While most somatic cells contain two copies of each chromosome (diploid), a certain subset may possess a single set of chromosomes (haploid), specifically found in male ants, bees, and other hymenopterans. Hence, diversity is a defining characteristic of somatic cells, reflecting in their structures, roles, and genetic makeup.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002371 "2010-09-24T09:44:42Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002371 "BTO:0001268")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002371 "FMA:72300")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002371 "WBbt:0008378")
-AnnotationAssertion(oboInOwl:inSubset obo:CL_0002371 cl:cellxgene_subset)
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002371 "https://cellxgene.cziscience.com/cellguide/CL_0002371")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002371 ubprop:_upper_level)
AnnotationAssertion(rdfs:label obo:CL_0002371 "obsolete somatic cell")
AnnotationAssertion(owl:deprecated obo:CL_0002371 "true"^^xsd:boolean)
@@ -22631,6 +22961,7 @@ AnnotationAssertion(oboInOwl:creation_date obo:CL_0002372 "2010-09-24T01:13:01Z"
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0002372 "FBbt:00005812")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBbt:00005812") oboInOwl:hasExactSynonym obo:CL_0002372 "myofiber")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBbt:00005812") oboInOwl:hasExactSynonym obo:CL_0002372 "myofibril")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002372 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002372 "myotube")
EquivalentClasses(obo:CL_0002372 ObjectIntersectionOf(obo:CL_0000187 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0030017) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0001908) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0002478)))
SubClassOf(obo:CL_0002372 obo:CL_0000737)
@@ -22680,6 +23011,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:cvs") Annotation(oboInOwl
AnnotationAssertion(terms:contributor obo:CL_0002376 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002376 "2010-09-24T02:10:26Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_0002376 "Schwann cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002376 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002376 "non-myelinating Schwann cell")
SubClassOf(obo:CL_0002376 obo:CL_0002573)
SubClassOf(obo:CL_0002376 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002377))
@@ -22846,7 +23178,7 @@ AnnotationAssertion(terms:contributor obo:CL_0002394 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002454 "2010-11-22T01:10:28Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002454 "DC.8-4-11b+")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002454 "spleen double-negative dendritic cell")
-AnnotationAssertion(rdfs:label obo:CL_0002454 "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell")
+AnnotationAssertion(rdfs:label obo:CL_0002454 "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell")
EquivalentClasses(obo:CL_0002454 ObjectIntersectionOf(obo:CL_0002465 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002454 obo:CL_0002465)
SubClassOf(obo:CL_0002454 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004))
SubClassOf(obo:CL_0002454 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084))
-# Class: obo:CL_0002455 (CD8_alpha-negative plasmacytoid dendritic cell)
+# Class: obo:CL_0002455 (CD8-alpha-negative plasmacytoid dendritic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002455 "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002455 "A CD11c-low plasmacytoid dendritic cell that is CD8-alpha-negative and CD4-positive.")
AnnotationAssertion(terms:contributor obo:CL_0002455 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002455 "2010-11-22T01:27:37Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002455 "DC.pDC.8-")
-AnnotationAssertion(rdfs:label obo:CL_0002455 "CD8_alpha-negative plasmacytoid dendritic cell")
+AnnotationAssertion(rdfs:label obo:CL_0002455 "CD8-alpha-negative plasmacytoid dendritic cell")
EquivalentClasses(obo:CL_0002455 ObjectIntersectionOf(obo:CL_0000989 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001004)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002455 obo:CL_0000989)
SubClassOf(obo:CL_0002455 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084))
SubClassOf(obo:CL_0002455 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001004))
-# Class: obo:CL_0002456 (CD8_alpha-positive plasmacytoid dendritic cell)
+# Class: obo:CL_0002456 (CD8-alpha-positive plasmacytoid dendritic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002456 "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002456 "A CD11c-low plasmacytoid dendritic cell that is CD8-alpha-positive and CD4-positive.")
AnnotationAssertion(terms:contributor obo:CL_0002456 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002456 "2010-11-22T01:23:07Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002456 "DC.pDC.8+")
-AnnotationAssertion(rdfs:label obo:CL_0002456 "CD8_alpha-positive plasmacytoid dendritic cell")
+AnnotationAssertion(rdfs:label obo:CL_0002456 "CD8-alpha-positive plasmacytoid dendritic cell")
EquivalentClasses(obo:CL_0002456 ObjectIntersectionOf(obo:CL_0000989 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001004) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001084)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002456 obo:CL_0000989)
SubClassOf(obo:CL_0002456 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001004))
@@ -23656,15 +23986,15 @@ EquivalentClasses(obo:CL_0002459 ObjectIntersectionOf(obo:CL_0001006 ObjectSomeV
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002459 obo:CL_0001006)
SubClassOf(obo:CL_0002459 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001010))
-# Class: obo:CL_0002460 (CD8alpha-negative thymic conventional dendritic cell)
+# Class: obo:CL_0002460 (CD8-alpha-negative thymic conventional dendritic cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:19273629") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002460 "A conventional thymic dendritic cell that is CD8alpha-negative.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:19273629") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002460 "A conventional thymic dendritic cell that is CD8-alpha-negative.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002460 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002460 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002460 "2010-11-23T10:58:53Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002460 "DC.8-.Th")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002460 core:human_reference_atlas)
-AnnotationAssertion(rdfs:label obo:CL_0002460 "CD8alpha-negative thymic conventional dendritic cell")
+AnnotationAssertion(rdfs:label obo:CL_0002460 "CD8-alpha-negative thymic conventional dendritic cell")
EquivalentClasses(obo:CL_0002460 ObjectIntersectionOf(obo:CL_0000941 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002460 obo:CL_0000941)
SubClassOf(obo:CL_0002460 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084))
@@ -23734,6 +24064,10 @@ AnnotationAssertion(terms:contributor obo:CL_0002466 )
EquivalentClasses(obo:CL_0002466 ObjectIntersectionOf(obo:CL_0002465 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001010) ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001006) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001013)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002466 obo:CL_0002465)
SubClassOf(obo:CL_0002466 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001010))
@@ -23856,7 +24190,6 @@ AnnotationAssertion(rdfs:label obo:CL_0002476 "bone marrow macrophage")
EquivalentClasses(obo:CL_0002476 ObjectIntersectionOf(obo:CL_0000864 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001014) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002980) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001813) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002062)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002476 obo:CL_0000864)
SubClassOf(obo:CL_0002476 obo:CL_0010004)
-SubClassOf(obo:CL_0002476 obo:PR_000050567)
SubClassOf(obo:CL_0002476 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001014))
SubClassOf(obo:CL_0002476 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020))
SubClassOf(obo:CL_0002476 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002980))
@@ -23868,10 +24201,10 @@ SubClassOf(obo:CL_0002476 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002062))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002477 "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive.")
AnnotationAssertion(terms:contributor obo:CL_0002477 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002477 "2010-11-23T04:31:28Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002477 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002477 "adipose macrophage")
EquivalentClasses(obo:CL_0002477 ObjectIntersectionOf(obo:CL_0000864 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001006) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001013) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001968)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002477 obo:CL_0000864)
-SubClassOf(obo:CL_0002477 obo:PR_000050567)
SubClassOf(obo:CL_0002477 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001006))
SubClassOf(obo:CL_0002477 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001013))
SubClassOf(obo:CL_0002477 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001968))
@@ -23903,15 +24236,18 @@ SubClassOf(obo:CL_0002479 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001813))
# Class: obo:CL_0002480 (nasal mucosa goblet cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:cjm") Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002480 "A goblet cell located in the nasal epithelium.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_0002480 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002480 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002480 "2010-12-03T03:03:02Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002480 "MP:0002262")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002480 cl:cellxgene_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_0002480 "The marker set LYPD2, MUC5AC can identify the Human cell type nasal mucosa goblet cell in the Lung with a confidence of 0.81 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_0002480 "nasal mucosa goblet cell")
EquivalentClasses(obo:CL_0002480 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001826)))
SubClassOf(obo:CL_0002480 obo:CL_0002370)
SubClassOf(obo:CL_0002480 obo:CL_0002631)
SubClassOf(obo:CL_0002480 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005384))
+SubClassOf(obo:CL_0002480 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000027))
# Class: obo:CL_0002481 (peritubular myoid cell)
@@ -24031,6 +24367,7 @@ SubClassOf(obo:CL_0002490 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000222
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002491 "A specialized cell involved in auditory sensory perception.")
AnnotationAssertion(terms:contributor obo:CL_0002491 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002491 "2010-12-06T03:18:43Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002491 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002491 "auditory epithelial cell")
EquivalentClasses(obo:CL_0002491 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050910)))
SubClassOf(obo:CL_0002491 obo:CL_0000098)
@@ -24170,7 +24507,13 @@ SubClassOf(obo:CL_0002503 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000574
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002504 "A smooth muscle cell of the intestine.")
AnnotationAssertion(terms:contributor obo:CL_0002504 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrgastro.2012.168") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1365-2982.2012.01986.x") Annotation(oboInOwl:hasDbXref "DOI:10.1371/journal.pcbi.1009644") terms:description obo:CL_0002504 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Enteric smooth muscle cells are a specialized type of cell found in the gastrointestinal tract. They are an integral part of the enteric nervous system, which regulates the functions of the gastrointestinal system. These cells have a unique structural organization that enables their primary function: the contraction and relaxation necessary for the propulsion of gastrointestinal contents.
+Smooth muscle cells in the enteric system possess unique attributes that distinguish them from other smooth muscle cells in the body. One crucial function is peristalsis, where these cells contract in a coordinated manner, generating a wave of contraction and relaxation. This peristaltic movement facilitates the movement of food particles through the digestive tract, playing a vital role in the digestion and absorption processes in animals. Additionally, these cells are responsible for maintaining the tone of gastrointestinal sphincters, controlling passage and preventing one-sided movement of the contents.
+Enteric smooth muscle cells are also involved in local immune responses of the gastrointestinal tract. They can communicate with local immune cells and secrete cytokines or other signaling molecules in response to infectious organisms, which makes them crucial mediocellular players in gastrointestinal homeostasis and response to disease. Their interactions with other cell types, such as neurons, myofibroblasts, and interstitial cells of Cajal, further contribute to these cells' role in maintaining the physiological functions of the gastrointestinal system. Overall, enteric smooth muscle cells provide an indispensable contribution to the complex operations of the digestive tract.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002504 "2011-01-17T03:39:38Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002504 "https://cellxgene.cziscience.com/cellguide/CL_0002504")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002504 "intestinal smooth muscle cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002504 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002504 "enteric smooth muscle cell")
@@ -24281,22 +24624,22 @@ SubClassOf(obo:CL_0002512 obo:CL_0002454)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002512 obo:CL_0002508)
SubClassOf(obo:CL_0002512 ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001012))
-# Class: obo:CL_0002513 (Vgamma5-positive CD8alpha alpha positive gamma-delta intraepithelial T cell)
+# Class: obo:CL_0002513 (Vgamma5-positive CD8-alpha alpha positive gamma-delta intraepithelial T cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002513 "A CD8alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002513 "A CD8-alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment.")
AnnotationAssertion(terms:contributor obo:CL_0002513 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002513 "2011-01-24T10:22:18Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002513 "tgd.vg5+.IEL")
-AnnotationAssertion(rdfs:label obo:CL_0002513 "Vgamma5-positive CD8alpha alpha positive gamma-delta intraepithelial T cell")
+AnnotationAssertion(rdfs:label obo:CL_0002513 "Vgamma5-positive CD8-alpha alpha positive gamma-delta intraepithelial T cell")
SubClassOf(obo:CL_0002513 obo:CL_0000802)
-# Class: obo:CL_0002514 (Vgamma5-negative CD8alpha alpha positive gamma-delta intraepithelial T cell)
+# Class: obo:CL_0002514 (Vgamma5-negative CD8-alpha alpha positive gamma-delta intraepithelial T cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002514 "A CD8alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002514 "A CD8-alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment.")
AnnotationAssertion(terms:contributor obo:CL_0002514 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002514 "2011-01-24T10:25:44Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002514 "tgd.vg5-.IEL")
-AnnotationAssertion(rdfs:label obo:CL_0002514 "Vgamma5-negative CD8alpha alpha positive gamma-delta intraepithelial T cell")
+AnnotationAssertion(rdfs:label obo:CL_0002514 "Vgamma5-negative CD8-alpha alpha positive gamma-delta intraepithelial T cell")
SubClassOf(obo:CL_0002514 obo:CL_0000802)
# Class: obo:CL_0002515 (interrenal norepinephrine type cell)
@@ -24528,6 +24871,7 @@ AnnotationAssertion(obo:RO_0002175 obo:CL_0002536 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002536 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002536 "2011-02-28T12:38:01Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002536 "amniotic epithelial cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002536 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002536 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0002536 "epithelial cell of amnion")
EquivalentClasses(obo:CL_0002536 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000305)))
@@ -24549,7 +24893,7 @@ SubClassOf(obo:CL_0002537 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000030
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:23720296") obo:IAO_0000115 obo:CL_0002538 "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes.")
AnnotationAssertion(terms:contributor obo:CL_0002538 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/hep.31252") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.ajpath.2023.02.012") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2010.06.020") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.gastha.2022.07.015") terms:description obo:CL_0002538 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/hep.31252") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.ajpath.2023.02.012") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2010.06.020") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.gastha.2022.07.015") terms:description obo:CL_0002538 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Intrahepatic cholangiocytes represent a subset of the biliary epithelial cells that form a network of tubes in the liver called the biliary tree The intrahepatic cholangiocytes reside specifically in the intrahepatic bile ducts and play a crucial role in liver physiology and bile production and secretion, thereby aiding in the digestion and absorption of fats in the small intestine. These specific cholangiocytes arise from bipotent hepatoblasts, whereas extrahepatic cholangiocytes share an embryologic origin with the ventral pancreas.
Recent research suggests that there is also heterogeneity within populations of intrahepatic cholangiocytes with different transcriptional profiles, proliferative capacity, and biological function; for example, subpopulations differ in calcium-mobilizing receptors.
@@ -24569,8 +24913,15 @@ SubClassOf(obo:CL_0002538 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000482
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002539 "A smooth muscle cell of the aorta.")
AnnotationAssertion(terms:contributor obo:CL_0002539 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.devcel.2005.05.017") Annotation(oboInOwl:hasDbXref "DOI:10.1111/febs.12414") Annotation(oboInOwl:hasDbXref "DOI:10.7150/ijbs.49871") Annotation(oboInOwl:hasDbXref "https://training.seer.cancer.gov/anatomy/cells_tissues_membranes/tissues/muscle.html") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-smooth-muscle-cell") terms:description obo:CL_0002539 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Aortic smooth muscle cells are specialized and highly differentiated muscle cells that are located in the tunica media layer of the aorta. They consist of spindle-shaped cells with a centrally located nucleus. These cells are rich in actin and myosin, muscle contractile proteins, that allow them to exert force and change shape.
+Aortic smooth muscle cells play a vital role in maintaining blood pressure and circulation, and are essential for vascular integrity and function. The primary function of these cells is contraction and relaxation, which enables the regulation of blood flow and pressure in the aorta, and helps in the distribution of oxygen and nutrients throughout the body.
+Additionally, a critical characteristic of smooth muscle cells is their plasticity. They can undergo phenotypic modulation in response to changes in their environment or vascular injury, switching from a contractile to a synthetic phenotype. The contractile phenotype is characterized by high contractility and low proliferation rate, while the synthetic phenotype is marked by increased cell proliferation and matrix synthesis but reduced contractile function.
+Aortic smooth muscle cells have a significant role in the physiological and pathological processes of the cardiovascular system. In the normal physiological state, they contribute to the elasticity and flexibility of the aorta. Conversely, in pathological states, changes in the function and structure of aortic smooth muscle cells are connected with various vascular diseases, including atherosclerosis, hypertension, and aneurysm.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002539 "2011-02-28T01:42:12Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002539 "BTO:0004577")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002539 "https://cellxgene.cziscience.com/cellguide/CL_0002539")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002539 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002539 "aortic smooth muscle cell")
EquivalentClasses(obo:CL_0002539 ObjectIntersectionOf(obo:CL_0000359 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004178)))
@@ -24608,7 +24959,7 @@ AnnotationAssertion(owl:deprecated obo:CL_0002542 "true"^^xsd:boolean)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002543 "An endothelial cell that is part of the vein.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002543 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002543 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00441-008-0706-5") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41569-022-00770-1") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41598-021-01360-w") Annotation(oboInOwl:hasDbXref "DOI:10.3390/ijms20184411") terms:description obo:CL_0002543 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00441-008-0706-5") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41569-022-00770-1") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41598-021-01360-w") Annotation(oboInOwl:hasDbXref "DOI:10.3390/ijms20184411") terms:description obo:CL_0002543 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Vein endothelial cells form a thin layer of squamous cells, the endothelium, lining the interior surface of veins throughout the body. They shape the inner cellular lining of the entire vascular system, including the heart, playing a crucial role in blood circulation. The unique characteristic compact arrangement of these cells enables veins to act as a barrier between the blood (that can contain foreign substances) and the surrounding venous tissue and maintain the integrity of the vascular system.
The primary function of vein endothelial cells is to control the exchange of substances between the bloodstream and the surrounding tissues. They facilitate selective transportation of molecules depending on their size and solubility, including gases, nutrients, hormones, and waste products. Vein endothelial cells also play a protective role by inhibiting the translocation of toxins or pathogens from blood to tissues. Additionally, these cells are involved in blood coagulation and inflammation response, primarily by producing substances that inhibit blood clot formation under normal conditions and initiating clotting when necessary.
@@ -24653,6 +25004,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo
AnnotationAssertion(terms:contributor obo:CL_0002546 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002546 "2011-02-28T04:20:39Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0002546 "ZFA:0005773")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002546 cl:cellxgene_subset)
AnnotationAssertion(rdfs:comment obo:CL_0002546 "See CL:0002619.")
AnnotationAssertion(rdfs:label obo:CL_0002546 "embryonic blood vessel endothelial progenitor cell")
SubClassOf(obo:CL_0002546 obo:CL_0000222)
@@ -24739,6 +25091,7 @@ SubClassOf(obo:CL_0002553 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000204
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002554 "A fibroblast of the lymphatic system.")
AnnotationAssertion(terms:contributor obo:CL_0002554 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002554 "2011-02-28T05:16:18Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002554 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002554 "fibroblast of lymphatic vessel")
EquivalentClasses(obo:CL_0002554 ObjectIntersectionOf(obo:CL_0000057 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001473)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002554 obo:CL_0000057)
@@ -24836,13 +25189,13 @@ SubClassOf(obo:CL_0002562 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000600
# Class: obo:CL_0002563 (intestinal epithelial cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002563 "An epithelial cell of the intestine.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002563 "An epithelial cell of the lining of the intestine.")
AnnotationAssertion(terms:contributor obo:CL_0002563 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002563 "2011-03-01T05:18:31Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0002563 "ZFA:0009399")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002563 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002563 "intestinal epithelial cell")
-EquivalentClasses(obo:CL_0002563 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000160)))
+EquivalentClasses(obo:CL_0002563 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001277)))
SubClassOf(obo:CL_0002563 obo:CL_0002251)
SubClassOf(obo:CL_0002563 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001277))
@@ -24862,6 +25215,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo
AnnotationAssertion(obo:RO_0002175 obo:CL_0002565 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002565 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002565 "2011-03-01T05:28:52Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002565 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002565 cl:eye_upper_slim)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002565 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0002565 "iris pigment epithelial cell")
@@ -24915,7 +25269,7 @@ SubClassOf(obo:CL_0002569 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000342
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002570 "A mesenchymal stem cell of adipose tissue.")
AnnotationAssertion(terms:contributor obo:CL_0002570 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.biopha.2019.108765") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.tibtech.2006.01.010") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41536-019-0083-6") Annotation(oboInOwl:hasDbXref "DOI:10.1096/fj.202100332R") Annotation(oboInOwl:hasDbXref "DOI:10.1111/dgd.12049") terms:description obo:CL_0002570 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.biopha.2019.108765") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.tibtech.2006.01.010") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41536-019-0083-6") Annotation(oboInOwl:hasDbXref "DOI:10.1096/fj.202100332R") Annotation(oboInOwl:hasDbXref "DOI:10.1111/dgd.12049") terms:description obo:CL_0002570 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Mesenchymal stem cells of adipose tissue, also known commonly as adipose-derived stem cells (ADSCs), are a population of adult stem cells that can be obtained easily from adipose tissues. They have many of the same regenerative properties as other mesenchymal stem cells, but are more easily accessible than bone marrow-derived stem cells.
Adipose-derived stem cells show immense promise in the field of regenerative medicine due to their ability to differentiate into adipocytes, chondrocytes, myocytes, osteoblasts, and other cell types. ADSCs also possess immunomodulatory and homeostatic functions: they have the ability to suppress immune responses and provide a therapeutic environment for tissue repair and regeneration, as well as supporting the proliferation of adipocytes and the overall expansion of adipose tissue and contributing to the tissue's ability to react to demands of energy storage and mobilization. Dysfunction of these cells may contribute to metabolic complications observed in obesity and diabetes.
@@ -24955,7 +25309,7 @@ SubClassOf(obo:CL_0002572 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000241
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:16807057") obo:IAO_0000115 obo:CL_0002573 "A glial cell that myelinates or ensheathes axons in the peripheral nervous system.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002573 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002573 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/glia.23892") Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-0-444-52902-2.00005-9") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2006.05.007") Annotation(oboInOwl:hasDbXref "DOI:10.1186/1742-2094-8-110") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s13064-020-00140-y") terms:description obo:CL_0002573 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/glia.23892") Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-0-444-52902-2.00005-9") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2006.05.007") Annotation(oboInOwl:hasDbXref "DOI:10.1186/1742-2094-8-110") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s13064-020-00140-y") terms:description obo:CL_0002573 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Schwann cells, also known as neurolemmocytes, are a type of glial cell located in the peripheral nervous system. These cells play a significant role in the healthy functioning of nerves by producing myelin, a fatty substance that forms a coating around nerve fibers. Myelin serves as an insulator and enhances the speed and efficiency of electrical nerve impulses; a single Schwann cell can myelinate a single axon. Myelination starts by the elongation and envelopment of the Schwann cell around the axon, followed by the synthesis and deposition of myelin layers. Some studies suggest that Schwann cells may regulate neuronal action potential, muscular contraction, and the sensitive response.
While Schwann cells are most commonly known for the formation of the myelin sheath, some Schwann cells do not form myelin: Remak Schwann cells, a class of nonmyelinating Schwann cells, ensheath axons with smaller diameter, such as C fiber nociceptors in sciatic nerves and form Remak bundles.
@@ -25094,7 +25448,7 @@ SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002584 obo:CL_0002681
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002585 "A blood vessel endothelial cell that is part of the retina.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002585 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002585 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:0.1016/j.preteyeres.2015.08.001") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.preteyeres.2012.08.004") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nature04482") Annotation(oboInOwl:hasDbXref "DOI:10.5301/EJO.2010.6049") terms:description obo:CL_0002585 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:0.1016/j.preteyeres.2015.08.001") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.preteyeres.2012.08.004") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nature04482") Annotation(oboInOwl:hasDbXref "DOI:10.5301/EJO.2010.6049") terms:description obo:CL_0002585 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Retinal blood vessel endothelial cells constitute the innermost lining of the blood vessels found in the retina, the light-sensitive layer of tissue at the back of the eye. The primary role of these cells revolves around their location within the retinal vascular system, forming the structure of the blood-retinal barrier, a subset of the larger blood-ocular barrier system.
The endothelial cells are particularly involved in the growth of new retinal blood vessels from pre-existing ones (angiogenesis); this is critical in managing the amount of oxygen and essential nutrients delivered to the ocular tissues. They are crucial for maintaining homeostasis in the retinal environment by controlling the exchange of molecules between the blood and the retina. Furthermore, they mediate immune cell trafficking, supporting the immune privilege of the eye by preventing the unrestricted infiltration of inflammatory cells into the retina, thus maintaining ocular health and normal vision.
@@ -25115,7 +25469,7 @@ SubClassOf(obo:CL_0002585 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000096
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002586 "An epithelial cell of the retinal pigmented epithelium.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002586 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002586 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1111/febs.16018") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00021.2004") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphar.2021.727870/full") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/chemistry/retinal-pigment") terms:description obo:CL_0002586 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1111/febs.16018") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00021.2004") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphar.2021.727870/full") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/chemistry/retinal-pigment") terms:description obo:CL_0002586 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Retinal pigment epithelial (RPE) cells form a single layer of cells at the back of the eye sandwiched between the neurosensory retina and the choroid, playing a significant role in maintaining vision health. These pigment-laden cells are highly specialized and perform an array of metabolic and transport functions essential for the maintenance of the photoreceptor cells (rods and cones) in the retina. The pigmentation of RPE cells actively aids in the absorption of excess light and the prevention of light scattering, thus enhancing the eye's optical properties.
The retinal pigment epithelium forms a key part of the blood/retina barrier. The cells have long sheet-like microvilli on their apical membrane that project into the light-sensitive outer segments of the photoreceptors, forming a close structural interaction. The basolateral membrane of the RPE interacts with the underlying Bruch’s membrane, which separates the RPE cells from fenestrated endothelium of the choriocapillaris.
@@ -25178,8 +25532,14 @@ SubClassOf(obo:CL_0002590 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000095
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002591 "A smooth muscle of the pulmonary artery.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002591 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002591 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.apsb.2012.12.007") Annotation(oboInOwl:hasDbXref "DOI:10.1124/pr.115.010652") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/medicine-and-dentistry/pulmonary-artery-smooth-muscle-cell") terms:description obo:CL_0002591 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Smooth muscle cells of the pulmonary artery form a principal component of the pulmonary artery's media layer, the middle section of the artery wall typically found between endothelial inner layer (intima) and the outermost connective tissue layer (adventitia). The unique structure of these cells, defined by fusiform shape and the absence of striations, sets them apart from other muscle cell types, including cardiac and skeletal.
+The primary function of smooth muscle cells of the pulmonary artery is to regulate the diameter of the pulmonary artery, which in turn controls the flow of blood into the lungs. They accomplish this task through the contraction and relaxation, indicative of vasoconstriction and vasodilation respectively. When these cells contract, the diameter of the artery narrows, leading to reduced blood flow. Conversely, relaxation of these cells widens the artery, facilitating increased blood flow. Such blood flow modulation is crucial for the maintenance of blood pressure and ensuring that the lungs receive an adequate blood supply for efficient oxygen exchange.
+As a result, abnormal function or proliferation of these cells can contribute to conditions such as pulmonary hypertension, a condition characterized by high blood pressure in the arteries leading to the lungs. This can occur due to hypoxia (lack of enough oxygen), leading to excessive constriction or proliferation of the smooth muscle cells.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002591 "2011-03-06T05:01:28Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002591 "BTO:0003336")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002591 "https://cellxgene.cziscience.com/cellguide/CL_0002591")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002591 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002591 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0002591 "smooth muscle cell of the pulmonary artery")
@@ -25258,8 +25618,14 @@ SubClassOf(obo:CL_0002597 obo:CL_1001319)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_0002598 "Any smooth muscle cell that is part of some bronchus.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0002598 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0002598 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1152/japplphysiol.00313.2006") Annotation(oboInOwl:hasDbXref "DOI:10.1183/09031936.00019810") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK537353/") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/bronchial-muscle") terms:description obo:CL_0002598 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Bronchial smooth muscle cells are specialized types of cells found in the bronchi of the respiratory system in mammals. These bronchi are tubular structures that function to carry air from the trachea into the lungs. As part of the smooth muscle tissue, bronchial smooth muscle cells are involuntary cells, meaning they function with minimal direct voluntary control. They are characterized by their elongated spindle-shaped structure, with each cell containing a single central nucleus.
+The primary function of bronchial smooth muscle cells is to control airway diameter, which directly influences the flow of air into and out of the lungs. Muscular contractions and relaxations mediated by these cells enable the bronchi to constrict or expand, facilitating the regulation of respiratory airflow. Additionally, these cells play a pivotal role in immune responses as they produce and release various substances that can instigate or lessen inflammation of airway tissue. Furthermore, bronchial smooth muscle cells can proliferate and lay down collagen and other extracellular matrix proteins, contributing to the structural integrity of the bronchial tubes.
+In pathological conditions, such as asthma and chronic obstructive pulmonary disease, the function and biology of bronchial smooth muscle cells change. Asthma, for example, is associated with an abnormal increase in the mass of the bronchial smooth muscles, leading to narrowing of the airways and resultant breathing difficulties. These cells also exhibit altered contractile behavior and an augmented immune response during inflammatory lung diseases.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002598 "2011-03-06T05:46:39Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002598 "BTO:0004402")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002598 "https://cellxgene.cziscience.com/cellguide/CL_0002598")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002598 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002598 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0002598 "bronchial smooth muscle cell")
@@ -25281,7 +25647,13 @@ SubClassOf(obo:CL_0002599 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000104
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002600 "A smooth muscle cell of the trachea.")
AnnotationAssertion(terms:contributor obo:CL_0002600 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/s1357-2725(02)00259-5") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK9961") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/airway-smooth-muscle") terms:description obo:CL_0002600 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Smooth muscle cells of the trachea have a characteristic 'smooth' (non-striated) appearance under the microscope, a distinguishing feature that differentiates them from skeletal and cardiac muscle cells. The smooth appearance is due to the organization of actin and myosin filaments in the cell, which allows for a controlled, contractile function.
+These cells play a key role in controlling the diameter of the trachea, thus regulating the airflow. They are responsible for the involuntary constriction and relaxation of the trachea influencing the air passage during various physiological behaviors like breathing, coughing, and sneezing. This autonomic control allows for adaptations to specific body requirements without conscious control, such as increasing air flow during exercise or restricting it during rest.
+In conditions such as asthma, chronic bronchitis, and emphysema, there are changes in smooth muscle cells. For example, the mass of smooth muscle cells increases in chronic airway diseases, possibly in response to chronic inflammation. This increase may indicate a pathological condition or be a part of the body's response to injury and repair.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002600 "2011-03-06T05:50:28Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002600 "https://cellxgene.cziscience.com/cellguide/CL_0002600")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002600 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002600 "smooth muscle cell of trachea")
EquivalentClasses(obo:CL_0002600 ObjectIntersectionOf(obo:CL_0000192 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003126)))
@@ -25292,7 +25664,13 @@ SubClassOf(obo:CL_0002600 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000312
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002601 "A smooth muscle cell of the uterus.")
AnnotationAssertion(terms:contributor obo:CL_0002601 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1177/0036850419850431") Annotation(oboInOwl:hasDbXref "DOI:10.1203/00006450-199811000-00001") Annotation(oboInOwl:hasDbXref "DOI:10.3791/56639") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK532927/") terms:description obo:CL_0002601 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Uterine smooth muscle cells are specialized cells that make up the majority of the uterus and in particular, the myometrium. The myometrium is a thick, involuntary muscle layer, principally consisting of verticillate cell bundles that sculpt the helical architecture of the uterus. This dense muscular tissue, packed with uterine smooth muscle cells, is responsible for the significant contractile force witnessed during the physical processes of labor and childbirth.
+In the non-pregnant uterus, they exist in a quiescent phase. Upon implantation, these cells are primarily responsible for the expansion consequently allowing the uterus to accommodate the growing fetus. Towards the end of pregnancy, under the influence of hormonal and mechanical signals, uterine smooth muscle cells transition from a relaxed phase to an active contractile phase, culminating in the delivery of the fetus.
+At the cellular level, these transitions involve significant changes in the electrophysiological properties of uterine smooth muscle cells. Governed by a complex interplay of ion channels, transporters, and signaling proteins, these cells adjust their electrical activity, conduction properties, and contracting mechanisms. Any issues with these processes can result in problems such as preterm birth or labor dysfunction.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002601 "2011-03-06T05:53:28Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002601 "https://cellxgene.cziscience.com/cellguide/CL_0002601")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002601 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002601 "uterine smooth muscle cell")
EquivalentClasses(obo:CL_0002601 ObjectIntersectionOf(obo:CL_0000192 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000995)))
@@ -25398,8 +25776,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo
AnnotationAssertion(terms:contributor obo:CL_0002610 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002610 "2011-03-06T07:42:06Z"^^xsd:dateTime)
AnnotationAssertion(rdfs:label obo:CL_0002610 "raphe nuclei neuron")
-EquivalentClasses(obo:CL_0002610 ObjectIntersectionOf(obo:CL_0000117 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0004684)))
-SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002610 obo:CL_0000117)
+EquivalentClasses(obo:CL_0002610 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0004684)))
SubClassOf(obo:CL_0002610 obo:CL_2000029)
SubClassOf(obo:CL_0002610 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0004684))
@@ -25409,8 +25786,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo
AnnotationAssertion(terms:contributor obo:CL_0002611 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002611 "2011-03-06T07:43:34Z"^^xsd:dateTime)
AnnotationAssertion(rdfs:label obo:CL_0002611 "neuron of the dorsal spinal cord")
-EquivalentClasses(obo:CL_0002611 ObjectIntersectionOf(obo:CL_0000117 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002256)))
-SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002611 obo:CL_0000117)
+EquivalentClasses(obo:CL_0002611 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002256)))
SubClassOf(obo:CL_0002611 obo:CL_2000029)
SubClassOf(obo:CL_0002611 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002256))
@@ -25420,8 +25796,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo
AnnotationAssertion(terms:contributor obo:CL_0002612 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002612 "2011-03-06T07:46:03Z"^^xsd:dateTime)
AnnotationAssertion(rdfs:label obo:CL_0002612 "neuron of the ventral spinal cord")
-EquivalentClasses(obo:CL_0002612 ObjectIntersectionOf(obo:CL_0000117 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002257)))
-SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002612 obo:CL_0000117)
+EquivalentClasses(obo:CL_0002612 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002257)))
SubClassOf(obo:CL_0002612 obo:CL_2000029)
SubClassOf(obo:CL_0002612 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002257))
@@ -25431,7 +25806,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo
AnnotationAssertion(terms:contributor obo:CL_0002613 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002613 "2011-03-06T07:47:12Z"^^xsd:dateTime)
AnnotationAssertion(rdfs:label obo:CL_0002613 "striatum neuron")
-EquivalentClasses(obo:CL_0002613 ObjectIntersectionOf(obo:CL_0000117 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002435)))
+EquivalentClasses(obo:CL_0002613 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002435)))
SubClassOf(obo:CL_0002613 obo:CL_0012001)
SubClassOf(obo:CL_0002613 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002435))
@@ -25441,8 +25816,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo
AnnotationAssertion(terms:contributor obo:CL_0002614 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002614 "2011-03-06T07:48:42Z"^^xsd:dateTime)
AnnotationAssertion(rdfs:label obo:CL_0002614 "neuron of the substantia nigra")
-EquivalentClasses(obo:CL_0002614 ObjectIntersectionOf(obo:CL_0000117 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002038)))
-SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002614 obo:CL_0000117)
+EquivalentClasses(obo:CL_0002614 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002038)))
SubClassOf(obo:CL_0002614 obo:CL_2000029)
SubClassOf(obo:CL_0002614 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002038))
@@ -25489,7 +25863,7 @@ SubClassOf(obo:CL_0002617 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000031
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002618 "An endothelial cell of the umbilical vein.")
AnnotationAssertion(terms:contributor obo:CL_0002618 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/cyto.a.20952") Annotation(oboInOwl:hasDbXref "DOI:10.1007/s12015-006-0015-x") Annotation(oboInOwl:hasDbXref "DOI:10.1172/JCI107470") Annotation(oboInOwl:hasDbXref "DOI:10.3390/app10030938") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK53254/") terms:description obo:CL_0002618 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/cyto.a.20952") Annotation(oboInOwl:hasDbXref "DOI:10.1007/s12015-006-0015-x") Annotation(oboInOwl:hasDbXref "DOI:10.1172/JCI107470") Annotation(oboInOwl:hasDbXref "DOI:10.3390/app10030938") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK53254/") terms:description obo:CL_0002618 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Endothelial cells of the umbilical vein form the inner lining of the veins found in the umbilical cord. They are involved in tube formation and migration which are essential for angiogenesis, the process of generating new blood vessels; this is critical during the fetal stage for the development of the circulatory system. Endothelial cells of the umbilical vein also play a role in controlling the passage of white blood cells into tissues during inflammatory responses.
Because human umbilical vein endothelial cells (HUVECs) can easily be derived from the umbilical cord, and because they express common endothelial cell markers, they have been used as an epithelial cell model for studies on cell proliferation, migration, angiogenesis, and inflammation. They have been used as models for vascular diseases like atherosclerosis, for investigating how tumor cells infiltrate blood vessels and form metastases.
@@ -25536,6 +25910,7 @@ SubClassOf(obo:CL_0002620 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000209
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_0002621 "Any epithelial cell that is part of some gingival epithelium.")
AnnotationAssertion(terms:contributor obo:CL_0002621 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002621 "2011-03-14T12:46:28Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002621 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002621 "gingival epithelial cell")
EquivalentClasses(obo:CL_0002621 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001949)))
SubClassOf(obo:CL_0002621 obo:CL_1001576)
@@ -25589,6 +25964,7 @@ SubClassOf(obo:CL_0002625 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000481
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:dsd") obo:IAO_0000115 obo:CL_0002626 "An immature astrocyte.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002626 "immature astrocytic glia")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002626 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002626 "immature astrocyte")
SubClassOf(obo:CL_0002626 obo:CL_0000127)
@@ -25615,6 +25991,12 @@ SubClassOf(obo:CL_0002628 obo:CL_0000129)
# Class: obo:CL_0002629 (mature microglial cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:dsd") Annotation(oboInOwl:hasDbXref "PMID:11517395") Annotation(oboInOwl:hasDbXref "PMID:14612429") Annotation(oboInOwl:hasDbXref "PMID:15246020") Annotation(oboInOwl:hasDbXref "PMID:16177057") Annotation(oboInOwl:hasDbXref "PMID:18396103") Annotation(oboInOwl:hasDbXref "PMID:20021364") obo:IAO_0000115 obo:CL_0002629 "A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1745-7254.2007.00625.x") Annotation(oboInOwl:hasDbXref "DOI:10.1111/jnc.15689") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2022.997786") Annotation(oboInOwl:hasDbXref "DOI:10.4103/1673-5374.226386") Annotation(oboInOwl:hasDbXref "DOI:10.4103/1673-5374.322423") terms:description obo:CL_0002629 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Mature microglial cells represented one of the macrophage populations within the central nervous system (CNS). Microglial cells serve as the primary immune defense mechanism within the CNS, playing active roles in maintaining brain homeostasis and responding to pathological processes. In response to pathogens and injuries, microglial cells mature and change their morphology from a ramified shape with small processes (normal state) to an amoeboid shape (mature state).
+Mature microglial cells possess multiple functional abilities, thereby enabling them to execute diverse roles in order to maintain the health of surrounding neural cells. They act to clear away cellular debris, dead neurons, or plaque formations through the process of phagocytosis. They are also continuously scanning their environment and are able to detect subtle changes in the neural landscape caused by injury, disease, or infection. Upon detection of such changes, these cells become activated and present antigens and secrete cytokines and chemokines to initiate an inflammation response, which sustains the brain’s defense against injurious agents.
+Their role is not solely destructive or defensive: mature microglial cells also contribute to neurodevelopment by guiding the formation of neural circuits, synaptogenesis, and remodeling. Furthermore, they assist in managing synaptic plasticity, a key process in learning and memory functions. While the dysregulation of microglial cells has been implicated in various neurodegenerative diseases, they are also regarded as potential therapeutic targets for such conditions, given their crucial roles in maintaining CNS health.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002629 "https://cellxgene.cziscience.com/cellguide/CL_0002629")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18396103") oboInOwl:hasExactSynonym obo:CL_0002629 "activated microglia")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002629 "mature microglia")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18396103") oboInOwl:hasExactSynonym obo:CL_0002629 "reactive microglia")
@@ -25660,7 +26042,7 @@ SubClassOf(obo:CL_0002632 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000481
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:20699479") obo:IAO_0000115 obo:CL_0002633 "A basal cell in the respiratory tract.")
AnnotationAssertion(terms:contributor obo:CL_0002633 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1186/s12931-022-02042-5") Annotation(oboInOwl:hasDbXref "DOI:10.3389/falgy.2021.787128") Annotation(oboInOwl:hasDbXref "DOI:110.1038/s41385-020-00370-7") terms:description obo:CL_0002633 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1186/s12931-022-02042-5") Annotation(oboInOwl:hasDbXref "DOI:10.3389/falgy.2021.787128") Annotation(oboInOwl:hasDbXref "DOI:110.1038/s41385-020-00370-7") terms:description obo:CL_0002633 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Respiratory basal cells are highly specialized cells that serve a crucial role in the human airway epithelium, predominantly found lining the surfaces of the trachea and bronchi. These cells exhibit a distinctive columnar shape and are attached directly to the basal lamina. They are characterized by the presence of high amounts of cytoplasmic keratins, predominantly keratin 5 and 14, and transcription factor tumor protein (tp63), which set them apart from other types of lung epithelial cells such as ciliated cells and secretory cells.
Basal cells are essential for maintaining airway integrity. They make up one third of all respiratory epithelial cells and serve as stem cells as they can transform into different cell types, like goblet cells, ciliated cells, and club cells, when needed for homeostatic maintenance of the epithelial barrier or to repair and restore a healthy cellular environment after injury.
@@ -25713,7 +26095,6 @@ AnnotationAssertion(rdfs:label obo:CL_0002637 "keratinized epithelial cell of th
EquivalentClasses(obo:CL_0002637 ObjectIntersectionOf(obo:CL_0000237 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000159)))
SubClassOf(obo:CL_0002637 obo:CL_0000237)
SubClassOf(obo:CL_0002637 obo:CL_0002634)
-SubClassOf(obo:CL_0002637 obo:CL_0009066)
# Class: obo:CL_0002638 (bronchioalveolar stem cell)
@@ -25888,17 +26269,20 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002655 "FMA:70732")
AnnotationAssertion(rdfs:label obo:CL_0002655 "epithelial cell of stratum spinosum of esophageal epithelium")
SubClassOf(obo:CL_0002655 obo:CL_0002252)
-# Class: obo:CL_0002656 (glandular cell of endometrium)
+# Class: obo:CL_0002656 (glandular endometrial unciliated epithelial cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002656 "A glandular epithelial cell of the endometrium.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:25023676") obo:IAO_0000115 obo:CL_0002656 "A glandular epithelial cell of the endometrium. Following ovulation, these cells secrete a glycogen-rich substance known as histotroph or uterine milk, which nourishes the embryo if implantation occurs.")
AnnotationAssertion(terms:contributor obo:CL_0002656 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002656 "2011-07-08T03:54:08Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_0002656 "glandular cell of endometrium")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002656 "FMA:86489")
-AnnotationAssertion(rdfs:label obo:CL_0002656 "glandular cell of endometrium")
-EquivalentClasses(obo:CL_0002656 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004811)))
-SubClassOf(obo:CL_0002656 obo:CL_0002149)
+AnnotationAssertion(rdfs:label obo:CL_0002656 "glandular endometrial unciliated epithelial cell")
+EquivalentClasses(obo:CL_0002656 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002451) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032940)))
+SubClassOf(obo:CL_0002656 obo:CL_0000150)
+SubClassOf(obo:CL_0002656 obo:CL_0000152)
+SubClassOf(obo:CL_0002656 obo:CL_0009084)
SubClassOf(obo:CL_0002656 obo:CL_1001591)
-SubClassOf(obo:CL_0002656 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004811))
+SubClassOf(obo:CL_0002656 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002451))
# Class: obo:CL_0002657 (glandular cell of esophagus)
@@ -25908,7 +26292,7 @@ AnnotationAssertion(oboInOwl:creation_date obo:CL_0002657 "2011-07-08T03:55:57Z"
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002657 "FMA:86548")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002657 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002657 "glandular cell of esophagus")
-EquivalentClasses(obo:CL_0002657 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001043)))
+EquivalentClasses(obo:CL_0002657 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001976)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002657 obo:CL_0000150)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002657 obo:CL_0002252)
@@ -25932,7 +26316,7 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002659 "CALOHA:TS-1284")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002659 "FMA:86554")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002659 "glandular cell of stomach")
AnnotationAssertion(rdfs:label obo:CL_0002659 "glandular epithelial cell of stomach")
-EquivalentClasses(obo:CL_0002659 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000945)))
+EquivalentClasses(obo:CL_0002659 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001276)))
SubClassOf(obo:CL_0002659 obo:CL_0000150)
SubClassOf(obo:CL_0002659 obo:CL_0002178)
@@ -26049,7 +26433,7 @@ SubClassOf(obo:CL_0002670 obo:CL_0002665)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:21521739") obo:IAO_0000115 obo:CL_0002671 "An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout.")
AnnotationAssertion(terms:contributor obo:CL_0002671 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s12079-019-00511-z") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.cmet.2013.08.001") Annotation(oboInOwl:hasDbXref "DOI:10.1101/cshperspect.a006569") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fcell.2021.642352") terms:description obo:CL_0002671 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s12079-019-00511-z") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.cmet.2013.08.001") Annotation(oboInOwl:hasDbXref "DOI:10.1101/cshperspect.a006569") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fcell.2021.642352") terms:description obo:CL_0002671 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Endothelial stalk cells are specialized vascular cells vital in angiogenesis, a process through which new blood vessels are formed from pre-existing ones; specifically, endothelial stalk cells are involved in sprouting angiogenesis, where they help form the body of new blood vessels.
Vascular sprouting relies on the coordinated activity of migrating endothelial tip cells at the forefront and proliferating stalk cells that elongate the sprout. The process is tightly controlled by different growths factors: Vascular Endothelial Growth Factor acts on endothelial cells, inducing them to become endothelial tip cells that initiate sprouting. After sprouting initiation, activation of Notch signaling suppresses differentiation toward a tip cell phenotype and some of the endothelial cells differentiate into stalk cells, which follow tip cells, multiply, and elongate to provide a structural backbone to the growing vessel sprout.
@@ -26065,6 +26449,7 @@ SubClassOf(obo:CL_0002671 obo:CL_0000071)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:20959166") Annotation(oboInOwl:hasDbXref "PMID:21148186") obo:IAO_0000115 obo:CL_0002672 "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells.")
AnnotationAssertion(terms:contributor obo:CL_0002672 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002672 "2011-08-16T02:38:01Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0002672 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002672 "retinal progenitor cell")
SubClassOf(obo:CL_0002672 obo:BFO_0000002)
SubClassOf(obo:CL_0002672 obo:CL_0000048)
@@ -26074,7 +26459,13 @@ SubClassOf(obo:CL_0002672 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000133))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:18816858") obo:IAO_0000115 obo:CL_0002673 "A skeletal muscle cell that is part of the tongue.")
AnnotationAssertion(terms:contributor obo:CL_0002673 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/ca.21011") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK507782/") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK554405/") terms:description obo:CL_0002673 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Tongue muscle cells are responsible for essential functions like mastication, deglutition (swallowing), phonation (speech), and taste receptivity. They can be classified into two functional classes - extrinsic and intrinsic muscle cells.
+The extrinsic tongue muscle cells originate outside the tongue and are primarily involved in determining the position of the tongue within the mouth. Muscle groups such as the genioglossus, hyoglossus, and styloglossus are composed of these extrinsic muscle cells and grant the tongue its wide range of motion.
+The intrinsic tongue muscle cells, on the other hand, originate and function within the tongue itself, influencing the shape of the tongue during speech, eating, and swallowing. These cells can contract to alter the tongue's shape, making it long, short, curled, or flat, as needed. Together, these two types of muscle cells allow the tongue to perform its vital functions effectively. Moreover, they play a critical role in maintaining oral health by facilitating physical cleaning of the oral cavity and assisting in the mechanical breakdown of food.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002673 "2011-08-16T03:10:02Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002673 "https://cellxgene.cziscience.com/cellguide/CL_0002673")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0002673 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0002673 "tongue muscle cell")
EquivalentClasses(obo:CL_0002673 ObjectIntersectionOf(obo:CL_0008002 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000378)))
@@ -26147,7 +26538,6 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0002679 cl:blood_and_immune_upper_s
AnnotationAssertion(rdfs:label obo:CL_0002679 "natural helper lymphocyte")
EquivalentClasses(obo:CL_0002679 ObjectIntersectionOf(obo:CL_0000542 ObjectSomeValuesFrom(obo:CL_4030046 obo:GO_0042105) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001013) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001020) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001874) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000002981) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002065) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002979)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002679 obo:CL_0000542)
-SubClassOf(obo:CL_0002679 obo:PR_000050567)
SubClassOf(obo:CL_0002679 ObjectSomeValuesFrom(obo:CL_4030046 obo:GO_0042105))
SubClassOf(obo:CL_0002679 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001002))
SubClassOf(obo:CL_0002679 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012))
@@ -26165,7 +26555,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl
AnnotationAssertion(terms:contributor obo:CL_0002680 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002680 "2011-09-27T11:59:01Z"^^xsd:dateTime)
AnnotationAssertion(rdfs:label obo:CL_0002680 "PP cell of intestine")
-EquivalentClasses(obo:CL_0002680 ObjectIntersectionOf(obo:CL_0000696 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000160)))
+EquivalentClasses(obo:CL_0002680 ObjectIntersectionOf(obo:CL_0000696 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001277)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002680 obo:CL_0000696)
SubClassOf(obo:CL_0002680 obo:CL_1001516)
@@ -26187,6 +26577,7 @@ AnnotationAssertion(terms:contributor obo:CL_0003001 "https://orcid.org/0000-000
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0003001 "retinal ganglion D cell")
AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0003001 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0003001 "CL:0003001")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0003001 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0003001 "bistratified retinal ganglion cell")
EquivalentClasses(obo:CL_0003001 ObjectIntersectionOf(obo:CL_0000740 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070062)))
SubClassOf(obo:CL_0003001 obo:CL_0000740)
@@ -26584,6 +26975,7 @@ AnnotationAssertion(terms:contributor obo:CL_0003035 "https://orcid.org/0000-000
AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0003035 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0003035 "CL:0003035")
AnnotationAssertion(rdfs:label obo:CL_0003035 "M6 retinal ganglion cell")
+SubClassOf(obo:CL_0003035 obo:BFO_0000002)
SubClassOf(obo:CL_0003035 obo:CL_0000740)
SubClassOf(obo:CL_0003035 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070063))
SubClassOf(obo:CL_0003035 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000001243))
@@ -26741,7 +27133,6 @@ AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0003048 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0003048 "CL:0003048")
AnnotationAssertion(rdfs:label obo:CL_0003048 "L cone cell")
SubClassOf(obo:CL_0003048 obo:CL_0000573)
-SubClassOf(obo:CL_0003048 obo:PR_000050567)
SubClassOf(obo:CL_0003048 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001244))
# Class: obo:CL_0003049 (M cone cell)
@@ -26757,7 +27148,6 @@ AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0003049 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0003049 "CL:0003049")
AnnotationAssertion(rdfs:label obo:CL_0003049 "M cone cell")
SubClassOf(obo:CL_0003049 obo:CL_0000573)
-SubClassOf(obo:CL_0003049 obo:PR_000050567)
SubClassOf(obo:CL_0003049 ObjectSomeValuesFrom(obo:BFO_0000051 obo:PR_000001224))
# Class: obo:CL_0003050 (S cone cell)
@@ -26795,7 +27185,7 @@ AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0004001 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0004001 "CL:0004001")
AnnotationAssertion(rdfs:comment obo:CL_0004001 "Local interneurons form the category of interneurons whose axon stays entirely within the gray matter region where the cell body resides (Swanson, 2003, p. 245; Bota and Swanson, 2007, Fig. 3).")
AnnotationAssertion(rdfs:label obo:CL_0004001 "local interneuron")
-SubClassOf(obo:CL_0004001 obo:CL_0000402)
+SubClassOf(obo:CL_0004001 obo:CL_0000099)
SubClassOf(obo:CL_0004001 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002020))
# Class: obo:CL_0004115 (retinal ganglion cell B)
@@ -26990,6 +27380,7 @@ AnnotationAssertion(terms:contributor obo:CL_0004213 "https://orcid.org/0000-000
AnnotationAssertion(terms:contributor obo:CL_0004213 "https://orcid.org/0000-0002-5260-9315")
AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0004213 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0004213 "CL:0004213")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0004213 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0004213 "type 3a cone bipolar cell")
SubClassOf(obo:CL_0004213 obo:CL_0000755)
SubClassOf(obo:CL_0004213 ObjectSomeValuesFrom(obo:BFO_0000051 ObjectIntersectionOf(obo:GO_0030425 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0000405))))
@@ -27001,6 +27392,7 @@ AnnotationAssertion(terms:contributor obo:CL_0004214 "https://orcid.org/0000-000
AnnotationAssertion(terms:contributor obo:CL_0004214 "https://orcid.org/0000-0002-5260-9315")
AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0004214 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0004214 "CL:0004214")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0004214 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0004214 "type 3b cone bipolar cell")
SubClassOf(obo:CL_0004214 obo:CL_0000755)
SubClassOf(obo:CL_0004214 ObjectSomeValuesFrom(obo:BFO_0000051 ObjectIntersectionOf(obo:GO_0030425 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0001870))))
@@ -27012,6 +27404,7 @@ AnnotationAssertion(terms:contributor obo:CL_0004215 "https://orcid.org/0000-000
AnnotationAssertion(terms:contributor obo:CL_0004215 "https://orcid.org/0000-0002-5260-9315")
AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0004215 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0004215 "CL:0004215")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0004215 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0004215 "type 5a cone bipolar cell")
SubClassOf(obo:CL_0004215 obo:CL_0000757)
@@ -27022,6 +27415,7 @@ AnnotationAssertion(terms:contributor obo:CL_0004216 "https://orcid.org/0000-000
AnnotationAssertion(terms:contributor obo:CL_0004216 "https://orcid.org/0000-0002-5260-9315")
AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0004216 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0004216 "CL:0004216")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0004216 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0004216 "type 5b cone bipolar cell")
SubClassOf(obo:CL_0004216 obo:CL_0000757)
@@ -27034,6 +27428,7 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0004217 "A Horizontal Cell")
AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0004217 "cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_0004217 "H1")
AnnotationAssertion(oboInOwl:id obo:CL_0004217 "CL:0004217")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0004217 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0004217 "H1 horizontal cell")
SubClassOf(obo:CL_0004217 obo:CL_0000745)
SubClassOf(obo:CL_0004217 ObjectSomeValuesFrom(obo:CL_4030045 obo:GO_0030424))
@@ -27047,6 +27442,7 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0004218 "B Horizontal Cell")
AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0004218 "cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_0004218 "H2")
AnnotationAssertion(oboInOwl:id obo:CL_0004218 "CL:0004218")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0004218 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0004218 "H2 horizontal cell")
SubClassOf(obo:CL_0004218 obo:CL_0000745)
SubClassOf(obo:CL_0004218 ObjectSomeValuesFrom(obo:RO_0002120 obo:GO_0044316))
@@ -27054,13 +27450,11 @@ SubClassOf(obo:CL_0004218 ObjectSomeValuesFrom(obo:RO_0002120 obo:GO_0044316))
# Class: obo:CL_0004219 (A2 amacrine cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:24246263") Annotation(oboInOwl:hasDbXref "PMID:9620701") obo:IAO_0000115 obo:CL_0004219 "A bistratifed retinal amacrine cell with a small dendritic field, dendrite stratification in S1-S2, and a second dendrite stratification in S5. This cell type releases the neurotransmitter glycine.")
-AnnotationAssertion(obo:RO_0002175 obo:CL_0004219 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0004219 "https://orcid.org/0000-0001-7258-9596")
AnnotationAssertion(terms:contributor obo:CL_0004219 "https://orcid.org/0000-0002-5260-9315")
AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0004219 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0004219 "CL:0004219")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0004219 cl:cellxgene_subset)
-AnnotationAssertion(oboInOwl:inSubset obo:CL_0004219 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0004219 "A2 amacrine cell")
SubClassOf(obo:CL_0004219 obo:CL_0004250)
SubClassOf(obo:CL_0004219 obo:CL_0004251)
@@ -27154,8 +27548,8 @@ AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0004226 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0004226 "CL:0004226")
AnnotationAssertion(rdfs:label obo:CL_0004226 "monostratified amacrine cell")
EquivalentClasses(obo:CL_0004226 ObjectIntersectionOf(obo:CL_0004251 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070063)))
+SubClassOf(obo:CL_0004226 obo:CL_0004246)
SubClassOf(obo:CL_0004226 obo:CL_0004251)
-SubClassOf(obo:CL_0004226 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070063))
SubClassOf(obo:CL_0004226 ObjectSomeValuesFrom(obo:RO_0013001 obo:UBERON_0008924))
SubClassOf(obo:CL_0004226 ObjectSomeValuesFrom(obo:RO_0013001 obo:UBERON_0008925))
@@ -27231,13 +27625,11 @@ SubClassOf(obo:CL_0004231 ObjectSomeValuesFrom(obo:RO_0013001 obo:UBERON_0008925
# Class: obo:CL_0004232 (starburst amacrine cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:32032773") Annotation(oboInOwl:hasDbXref "PMID:9620701") obo:IAO_0000115 obo:CL_0004232 "An amacrine cell with a flat dendritic arbor and a medium dendritic field. Starburst amacrine cells have post-synaptic terminals in S2. This cell type releases the neurotransmitters gamma-aminobutyric acid (GABA) and acetylcholine.")
-AnnotationAssertion(obo:RO_0002175 obo:CL_0004232 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0004232 "https://orcid.org/0000-0001-7258-9596")
AnnotationAssertion(terms:contributor obo:CL_0004232 "https://orcid.org/0000-0002-5260-9315")
AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0004232 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0004232 "CL:0004232")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0004232 cl:cellxgene_subset)
-AnnotationAssertion(oboInOwl:inSubset obo:CL_0004232 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0004232 "starburst amacrine cell")
SubClassOf(obo:CL_0004232 obo:CL_0000108)
SubClassOf(obo:CL_0004232 obo:CL_4030027)
@@ -27426,7 +27818,7 @@ AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0004247 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0004247 "CL:0004247")
AnnotationAssertion(rdfs:label obo:CL_0004247 "bistratified cell")
EquivalentClasses(obo:CL_0004247 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070062)))
-SubClassOf(obo:CL_0004247 obo:CL_0000540)
+SubClassOf(obo:CL_0004247 obo:CL_2000029)
SubClassOf(obo:CL_0004247 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070062))
# Class: obo:CL_0004250 (bistratified retinal amacrine cell)
@@ -27454,24 +27846,20 @@ SubClassOf(obo:CL_0004251 obo:CL_0000561)
# Class: obo:CL_0004252 (medium field retinal amacrine cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:9620701") obo:IAO_0000115 obo:CL_0004252 "An amicrine that has a medium dendritic field.")
-AnnotationAssertion(obo:RO_0002175 obo:CL_0004252 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0004252 "https://orcid.org/0000-0001-7258-9596")
AnnotationAssertion(terms:contributor obo:CL_0004252 "https://orcid.org/0000-0002-5260-9315")
AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0004252 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0004252 "CL:0004252")
-AnnotationAssertion(oboInOwl:inSubset obo:CL_0004252 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0004252 "medium field retinal amacrine cell")
SubClassOf(obo:CL_0004252 obo:CL_0000561)
# Class: obo:CL_0004253 (wide field retinal amacrine cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:9620701") obo:IAO_0000115 obo:CL_0004253 "An amicrine that has a wide dendritic field.")
-AnnotationAssertion(obo:RO_0002175 obo:CL_0004253 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0004253 "https://orcid.org/0000-0001-7258-9596")
AnnotationAssertion(terms:contributor obo:CL_0004253 "https://orcid.org/0000-0002-5260-9315")
AnnotationAssertion(oboInOwl:hasOBONamespace obo:CL_0004253 "cell")
AnnotationAssertion(oboInOwl:id obo:CL_0004253 "CL:0004253")
-AnnotationAssertion(oboInOwl:inSubset obo:CL_0004253 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0004253 "wide field retinal amacrine cell")
SubClassOf(obo:CL_0004253 obo:CL_0000561)
@@ -27482,7 +27870,7 @@ AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0005012 "ZFA:0005242")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0005012 "https://cellxgene.cziscience.com/cellguide/CL_0005012")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0005012 "multi-ciliated epithelial cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0005012 "multiciliated epithelial cell"@en)
AnnotationAssertion(Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_0005012 "MCC"@en)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0005012 cl:cellxgene_subset)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:22118931") Annotation(oboInOwl:hasDbXref "PMID:23959957") Annotation(oboInOwl:hasDbXref "PMID:25729351") Annotation(oboInOwl:hasDbXref "PMID:26378583") rdfs:comment obo:CL_0005012 "While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility")
-AnnotationAssertion(rdfs:label obo:CL_0005012 "multi-ciliated epithelial cell")
+AnnotationAssertion(rdfs:label obo:CL_0005012 "multiciliated epithelial cell")
EquivalentClasses(obo:CL_0005012 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031514) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007)))
SubClassOf(obo:CL_0005012 obo:CL_0000067)
SubClassOf(obo:CL_0005012 obo:CL_0000075)
@@ -27694,7 +28083,7 @@ SubClassOf(obo:CL_0005018 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0036321))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:14970313") obo:IAO_0000115 obo:CL_0005019 "Ghrelin secreting cells found in the endocrine pancreas.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0005019 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00125-008-1238-y") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00012.2004") Annotation(oboInOwl:hasDbXref "DOI:10.1210/en.2018-00833") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fendo.2022.904004") Annotation(oboInOwl:hasDbXref "DOI:10.3390/ijms20081867") terms:description obo:CL_0005019 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00125-008-1238-y") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00012.2004") Annotation(oboInOwl:hasDbXref "DOI:10.1210/en.2018-00833") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fendo.2022.904004") Annotation(oboInOwl:hasDbXref "DOI:10.3390/ijms20081867") terms:description obo:CL_0005019 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Pancreatic epsilon cells are a specialized type of endocrine cell found in the islets of Langerhans, a region of the pancreas responsible for hormone production. These clusters of cells constitute only about 1% of the pancreatic islet cell population, making them a relatively small yet significant component of the pancreas. Pancreatic epsilon cells have a round or ovoid shape with occasional cytoplasmic extensions and are characterized by small and spherical granules.
The principal function of pancreatic epsilon cells involves the synthesis and release of the hormone ghrelin, a peptide hormone predominantly produced in the stomach; pancreatic epsilon cells are one of the few sites outside the gastrointestinal tract known to produce this hormone. Ghrelin has multiple vital roles, playing a significant part in generating hunger sensations, promoting fat storage, and influencing various metabolic processes. It also stimulates the release of Growth Hormone (GH) from the anterior pituitary gland.
@@ -27784,7 +28173,7 @@ SubClassOf(obo:CL_0005025 ObjectSomeValuesFrom(obo:RO_0002120 obo:CL_0011102))
# Class: obo:CL_0005026 (hepatoblast)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:CVS") Annotation(oboInOwl:hasDbXref "PMID:18356246") Annotation(oboInOwl:hasDbXref "PMID:20483998") Annotation(oboInOwl:hasDbXref "PMID:26798363") Annotation(oboInOwl:hasDbXref "https://orcid.org/0000-0003-1940-6740") obo:IAO_0000115 obo:CL_0005026 "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.stem.2014.04.010") Annotation(oboInOwl:hasDbXref "DOI:10.1093/jb/mvr001") Annotation(oboInOwl:hasDbXref "DOI:10.1242/dev.031369") Annotation(oboInOwl:hasDbXref "DOI:10.1242/dev.114215") Annotation(oboInOwl:hasDbXref "DOI:10.5966/sctm.2015-0051") terms:description obo:CL_0005026 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.stem.2014.04.010") Annotation(oboInOwl:hasDbXref "DOI:10.1093/jb/mvr001") Annotation(oboInOwl:hasDbXref "DOI:10.1242/dev.031369") Annotation(oboInOwl:hasDbXref "DOI:10.1242/dev.114215") Annotation(oboInOwl:hasDbXref "DOI:10.5966/sctm.2015-0051") terms:description obo:CL_0005026 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Hepatoblasts are immature precursor cells that predominate during the early stages of liver development, specifically in the embryonic phase of life. They first arise from the endoderm, one of the three primary germ layers in the very early embryo, and then differentiate into two distinct mature liver cell types - the hepatocytes and cholangiocytes.
During liver organogenesis hepatoblasts proliferate and migrate into the septum transversum to form the liver bud. Proliferation and differentiation of these cells are regulated by several soluble factors, such as hepatocyte growth factor, which is a mitogen of both hepatoblasts and mature hepatocytes. As they start to differentiate into hepatocytes and cholangiocytes, the cells begin to express hepatic markers like albumin and alpha-fetoprotein.
@@ -27857,6 +28246,7 @@ SubClassOf(obo:CL_0007004 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000133))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GO_REF:0000034") obo:IAO_0000115 obo:CL_0007005 "Cell that is part of the notochord.")
AnnotationAssertion(terms:contributor obo:CL_0007005 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_0007005 "2012-06-27T08:47:31Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0007005 cl:cellxgene_subset)
AnnotationAssertion(rdfs:comment obo:CL_0007005 "NOTE: TO DO, notochord development still needs work.")
AnnotationAssertion(rdfs:label obo:CL_0007005 "notochordal cell")
SubClassOf(obo:CL_0007005 obo:BFO_0000002)
@@ -27905,7 +28295,13 @@ SubClassOf(obo:CL_0007009 obo:CL_0000055)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GO_REF:0000034") obo:IAO_0000115 obo:CL_0007010 "Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells.")
AnnotationAssertion(terms:contributor obo:CL_0007010 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/srep32884") Annotation(oboInOwl:hasDbXref "DOI:10.1096/fba.2020-00058") Annotation(oboInOwl:hasDbXref "DOI:10.1210/endo.141.9.7634") Annotation(oboInOwl:hasDbXref "DOI:10.12659/MSMBR.901142") terms:description obo:CL_0007010 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Preosteoblast is a critical cell type involved in bone formation, crucial in a process known as ossification or osteogenesis. They are derived from mesenchymal stem cells and are an intermediate stage marking the transition from an osteoprogenitor cell to a fully differentiated osteoblast. The presence of preosteoblasts signifies the site of new bone deposition, highlighting their crucial role in skeletal development and in response to bone injury repairs.
+The primary function of preosteoblasts is to differentiate into osteoblasts, which are responsible for secreting osteoid (the unmineralized portion of bone matrix) and regulating the process of bone mineralization. Preosteoblasts are regulated by various growth factors and hormones, including bone morphogenic proteins (BMPs), fibroblast growth factors (FGFs), parathyroid hormone (PTH) and Vitamin D.
+However, the function of preosteoblasts is not limited to bone formation alone. In addition to osteogenesis, preosteoblasts significantly contribute to the maintenance of bone homeostasis through regulating the activity of osteoclasts - the cells responsible for bone resorption. This regulation is mediated through RANK/RANKL/OPG pathway signaling. Osteoprotegerin (OPG) released from the preosteoblasts acts as a decoy receptor for RANKL impairing osteoclast formation, hence preventing excessive bone resorption. This regulatory role indicates the dual functionality of preosteoblasts, which are indispensable for both the formation of new bone and the maintenance of existing bone tissue.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0007010 "2012-06-27T10:57:21Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0007010 "https://cellxgene.cziscience.com/cellguide/CL_0007010")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0007010 "osteoprogenitor cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0007010 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0007010 "preosteoblast")
@@ -28223,9 +28619,9 @@ SubClassOf(obo:CL_0008020 ObjectSomeValuesFrom(obo:RO_0002203 obo:CL_0008017))
# Class: obo:CL_0008021 (anterior lateral line ganglion neuron)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_0008021 "Any neuron that has its soma located in some anterior lateral line ganglion.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_0008021 "Any peripheral nervous system neuron that has its soma located in some anterior lateral line ganglion.")
AnnotationAssertion(rdfs:label obo:CL_0008021 "anterior lateral line ganglion neuron")
-EquivalentClasses(obo:CL_0008021 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_2001391)))
+EquivalentClasses(obo:CL_0008021 ObjectIntersectionOf(obo:CL_2000032 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_2001391)))
SubClassOf(obo:CL_0008021 obo:CL_2000031)
SubClassOf(obo:CL_0008021 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_2001391))
@@ -28318,7 +28714,7 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0008031 "cerebral cortex int
AnnotationAssertion(oboInOwl:inSubset obo:CL_0008031 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0008031 "cortical interneuron"@en)
EquivalentClasses(obo:CL_0008031 ObjectIntersectionOf(obo:CL_0000099 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000956)))
-SubClassOf(obo:CL_0008031 obo:CL_0000402)
+SubClassOf(obo:CL_0008031 obo:CL_0000099)
SubClassOf(obo:CL_0008031 obo:CL_0010012)
# Class: obo:CL_0008032 (rosehip neuron)
@@ -28328,9 +28724,10 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1038/s41593-018-0205-2
AnnotationAssertion(rdfs:label obo:CL_0008032 "rosehip neuron"@en)
SubClassOf(obo:CL_0008032 obo:BFO_0000002)
SubClassOf(obo:CL_0008032 obo:CL_0010011)
-SubClassOf(obo:CL_0008032 ObjectIntersectionOf(ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000005110) ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000007785)))
SubClassOf(obo:CL_0008032 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005390))
SubClassOf(obo:CL_0008032 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606))
+SubClassOf(obo:CL_0008032 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000005110))
+SubClassOf(obo:CL_0008032 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000007785))
SubClassOf(obo:CL_0008032 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000011467))
# Class: obo:CL_0008033 (decidual pericyte)
@@ -28375,7 +28772,13 @@ SubClassOf(obo:CL_0008035 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_001052
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31049600") obo:IAO_0000115 obo:CL_0008036 "A trophoblast cell that is not part of a placental villous.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0008036 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0008036 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s12522-011-0102-9") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.it.2017.01.009") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.preghy.2010.10.003") Annotation(oboInOwl:hasDbXref "DOI:10.1080/19336918.2015.1089376") Annotation(oboInOwl:hasDbXref "DOI:10.1080/19336918.2015.1120397") terms:description obo:CL_0008036 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Extravillous trophoblasts (EVTs), a specialized subset of trophoblast cells, play crucial roles in establishing and sustaining pregnancy.
+Firstly, they anchor the fetus to the maternal tissue, providing structural stability. Secondly, they are instrumental in modifying the maternal spiral arteries to ensure an adequate supply of maternal blood to the placenta and the developing fetus. EVTs invade maternal decidua and myometrium and replace the endothelial lining of the spiral arteries, transforming these high-resistance, narrow vessels into low-resistance, wide vessels, favouring higher blood flow. Thirdly, these cells also play an immunological role, creating an environment conducive to the acceptance of the semi-allogeneic fetus, by expressing non-classical MHC molecules, thereby averting any potential maternal immune response towards fetal tissues.
+While EVTs are commonly associated with healthy pregnancies, abnormalities in their function or development have been connected to problematic pregnancies. Conditions like pre-eclampsia and fetal growth restriction (FGR) may arise if EVT cells do not effectively invade the maternal decidua or adequately remodel.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_0008036 "2020-03-02T08:45:06Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0008036 "https://cellxgene.cziscience.com/cellguide/CL_0008036")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31049600") oboInOwl:hasExactSynonym obo:CL_0008036 "EVT")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0008036 "extravillous cytotrophloblast")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0008036 cl:added_for_HCA)
@@ -28419,8 +28822,8 @@ SubClassOf(obo:CL_0008039 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_7742
# Class: obo:CL_0008040 (squamous endothelial cell of venule)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0008040 "An endothelial cell of the venule that is squamous shaped. This is in contrast to the cubodial shape of high endothelial venule cells.")
-AnnotationAssertion(dc:date obo:CL_0008040 "2024-07-03T19:52:47Z")
AnnotationAssertion(terms:contributor obo:CL_0008040 )
+AnnotationAssertion(terms:date obo:CL_0008040 "2024-07-03T19:52:47Z"^^xsd:dateTime)
AnnotationAssertion(rdfs:label obo:CL_0008040 "squamous endothelial cell of venule"@en)
SubClassOf(obo:CL_0008040 obo:CL_0002653)
SubClassOf(obo:CL_0008040 obo:CL_1000414)
@@ -28541,10 +28944,20 @@ SubClassOf(obo:CL_0009005 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000104
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876") obo:IAO_0000115 obo:CL_0009006 "An enteroendocrine cell that is located in the small intestine.")
AnnotationAssertion(terms:contributor obo:CL_0009006 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.coph.2013.09.008") Annotation(oboInOwl:hasDbXref "DOI:10.1038/mi.2017.73") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nature24489") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1365-2613.2011.00767.x") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-021115-105439") terms:description obo:CL_0009006 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+The enteroendocrine cell of the small intestine is a specialized type of cell that forms part of the lining of the intestinal wall. These cells are interspersed among absorptive cells, mucus-secreting goblet cells, and other gut cell types, forming the crypt-villus axis, which is the functional unit of the small intestinal epithelium.
+Functionally, enteroendocrine cells play a pivotal role in the gut-endocrine system, which is responsible for the digestive process. These cells translate the luminal nutrient status into hormonal signals thereby acting as chemosensors. They contain secretory granules at their base which release hormones into the bloodstream following chemo-sensation. The hormones they secrete perform diverse functions including regulating gastric secretion, gut motility, insulin release, appetite control and other local and systemic effects.
+In addition to their endocrine functions, enteroendocrine cells also play a part in the modulation of the immune response in the gut. They can secrete cytokines and chemokines that have a role in directing the immune response to invading pathogens. Moreover, emerging research suggests that these cells play a role in maintaining the balance between gut resident bacteria, known as the gut microbiota, and the host. As such, a comprehensive understanding of the enteroendocrine cells of the small intestine underpins knowledge in nutrition, endocrinology, and various gastroenterological conditions.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0009006 "https://cellxgene.cziscience.com/cellguide/CL_0009006")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009006 "small intestine enteroendocrine cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009006 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009006 pato:location_grouping)
AnnotationAssertion(rdfs:label obo:CL_0009006 "enteroendocrine cell of small intestine")
+AnnotationAssertion(Annotation(dc:license "http://creativecommons.org/licenses/by/4.0/") Annotation(rdfs:comment "Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).
+
+ISC: Intestinal Stem Cell
+TA: Transit Amplifying Cells") foaf:depiction obo:CL_0009006 )
EquivalentClasses(obo:CL_0009006 ObjectIntersectionOf(obo:CL_0000164 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002108)))
SubClassOf(obo:CL_0009006 obo:CL_1001516)
SubClassOf(obo:CL_0009006 obo:CL_1001598)
@@ -28578,7 +28991,14 @@ SubClassOf(obo:CL_0009008 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_001118
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31753849") Annotation(oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865") obo:IAO_0000115 obo:CL_0009009 "A paneth cell that is located in the epithelium of the colon.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0009009 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0009009 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/ibd.20197") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nature09637") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrmicro2546") Annotation(oboInOwl:hasDbXref "DOI:10.1093/ecco-jcc/jjac190.0884") Annotation(oboInOwl:hasDbXref "DOI:10.1136/gut.48.2.176") terms:description obo:CL_0009009 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Paneth cells of the colon are specialized secretory epithelial cells that can be found in the large intestine, albeit in small numbers compared with the small intestine where Paneth cells are more abundant. Under disease conditions such as inflammatory bowel disease, Paneth cells increase in numbers in the colon. They reside in the crypts of Lieberkühn, which are glandular structures embedded within the mucosal layer of the small and large intestine.
+Paneth cells play a crucial role in maintaining intestinal homeostasis and acting as a frontline of defense in our bodies against ingested microbes. They achieve this through the secretion of antimicrobial peptides and proteins such as lysozyme and defensins, which can directly kill or inhibit the growth of various bacteria, fungi, and viruses. They degranulate these substances into the intestinal lumen, especially under conditions of pathogenic invasion or damage to the epithelial lining.
+Moreover, Paneth cells are essential for the maintenance of intestinal stem cells, which continually replace the epithelium of the intestine. They create a niche for these stem cells at the base of the crypts, secreting various signaling molecules and factors that are essential for the growth and differentiation of intestinal stem cells. In essence, the existence and function of Paneth cells are fundamental to the overall gut health and immune defense system, by providing both antimicrobial functions and a conducive environment for the renewal of the intestinal lining.
+The role of Paneth cells specifically in the colon is of interest in the context of inflammatory bowel disease, such as ulcerative colitis and Crohn’s disease: Their presence in the colon is thought to represent Paneth cell metaplasia and indicates a chronic inflammatory state.")
AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_0009009 "paneth cell of epithelium of large intestine")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0009009 "https://cellxgene.cziscience.com/cellguide/CL_0009009")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009009 "paneth cell of epithelium of colon")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009009 "paneth-like cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009009 cl:cellxgene_subset)
@@ -28609,7 +29029,12 @@ SubClassOf(obo:CL_0009010 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000034))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20801415") Annotation(oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865") obo:IAO_0000115 obo:CL_0009011 "A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the colon. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0009011 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0009011 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.cell.2014.02.057") Annotation(oboInOwl:hasDbXref "DOI:10.1053/j.gastro.2018.08.016") Annotation(oboInOwl:hasDbXref "DOI:10.1172/jci.insight.150894") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fbioe.2023.1189225") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/immunology-and-microbiology/intestinal-stem-cell") terms:description obo:CL_0009011 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Transit amplifying cells (TACs) are an intermediate, undifferentiated population between stem cells and differentiated cells. They can be found in multiple regions such as the small intestine and the colon. TACs of the colon, are integral components of the colonic crypts and vital players in the maintenance of colonic tissue.
+These cells serve a critical function in the rapid and constant renewal of the epithelium lining the colon, with the whole epithelial surface renewed approximately every 5-7 days. They divide rapidly and progressively differentiate into mature columnar epithelium cells, including enterocytes, goblet cells, and enteroendocrine cells. The continued proliferation of transit amplifying cells is fundamental to maintain the balance in cell population while preventing tissue degeneration and maintaining a state of homeostasis. However, uncontrolled proliferation and compromised differentiation capacity can contribute to the development of colon cancers.")
AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_0009011 "transit amplifying cell of large intestine")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0009011 "https://cellxgene.cziscience.com/cellguide/CL_0009011")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009011 "colon transit amplifying cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009011 "transient amplifying cell of colon")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009011 "transient amplifying cell of crypt of Lieberkuhn of colon")
@@ -28619,8 +29044,8 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0009011 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009011 pato:location_grouping)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009011 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0009011 "transit amplifying cell of colon")
-EquivalentClasses(obo:CL_0009011 ObjectIntersectionOf(obo:CL_0009010 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0013485)))
-SubClassOf(obo:CL_0009011 obo:CL_0009010)
+EquivalentClasses(obo:CL_0009011 ObjectIntersectionOf(obo:CL_4047017 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0013485)))
+SubClassOf(obo:CL_0009011 obo:CL_4047017)
SubClassOf(obo:CL_0009011 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0013485))
SubClassOf(obo:CL_0009011 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002250))
@@ -28628,6 +29053,12 @@ SubClassOf(obo:CL_0009011 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002250))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20801415") Annotation(oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865") obo:IAO_0000115 obo:CL_0009012 "A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the small intestine. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells.")
AnnotationAssertion(terms:contributor obo:CL_0009012 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s11894-010-0130-3") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.cell.2014.02.057") Annotation(oboInOwl:hasDbXref "DOI:10.1101/gad.1674008") terms:description obo:CL_0009012 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Transit amplifying cells (TACs) represent an intermediate population between stem cells and fully differentiated cells, and can be found in multiple regions such as the colon and the small intestine. The small intestine's efficiency in absorbing nutrients, its protective barrier function, and its innate cellular renewal every few days is largely dependent on the role played by these TACs.
+TACs of the small intestine are primarily present in the crypt-villus structure of the intestine, more specifically in the crypt region. They originate from Lgr5+ intestinal stem cells that reside at the base of the crypts. Following their derivation from stem cells, TACs undergo up to six rounds of rapid division over a 48-72 hour period, effectively amplifying the cell population, hence their name. During this process, they gradually migrate upward along the walls of the crypt from where they differentiate into diverse mature cell types such as enterocytes, goblet cells, and Paneth cells.
+TACs serve as an important element in the homeostasis and regeneration of the intestinal epithelium, amplifying the pool of cells available for differentiation. They also minimize genetic errors during DNA replication by serving as a 'buffer zone' between the long-lived stem cells and the terminal differentiated cells of the gut lining, thus reducing the potential for propagation of mutation-causing defects. Lastly, TACs play an essential part in gastrointestinal tissue repair following injury or inflammation. Their rapid proliferation and subsequent differentiation abilities often help expedite the wound healing process in the intestinal epithelium.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0009012 "https://cellxgene.cziscience.com/cellguide/CL_0009012")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009012 "small intestine transit amplifying cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009012 "transient amplifying cell of crypt of Lieberkuhn of small intestine")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009012 "transient amplifying cell of small intestine")
@@ -28636,8 +29067,12 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009012 "transit-amplifying
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009012 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009012 pato:location_grouping)
AnnotationAssertion(rdfs:label obo:CL_0009012 "transit amplifying cell of small intestine")
-EquivalentClasses(obo:CL_0009012 ObjectIntersectionOf(obo:CL_0009010 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001241)))
-SubClassOf(obo:CL_0009012 obo:CL_0009010)
+AnnotationAssertion(Annotation(dc:license "http://creativecommons.org/licenses/by/4.0/") Annotation(rdfs:comment "Figure depicts a cross section of intestinal villi in the small intestine , including the crypts of Lieberkhun (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).
+
+ISC: Intestinal Stem Cell
+TA: Transit Amplifying Cells") foaf:depiction obo:CL_0009012 )
+EquivalentClasses(obo:CL_0009012 ObjectIntersectionOf(obo:CL_4047017 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001241)))
+SubClassOf(obo:CL_0009012 obo:CL_4047017)
SubClassOf(obo:CL_0009012 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001241))
SubClassOf(obo:CL_0009012 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002250))
@@ -28696,7 +29131,7 @@ SubClassOf(obo:CL_0009016 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000198
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20683682") Annotation(oboInOwl:hasDbXref "https://orcid.org/0000-0003-4183-8865") obo:IAO_0000115 obo:CL_0009017 "An intestinal stem cell that is located in the small intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the small intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells.")
AnnotationAssertion(terms:contributor obo:CL_0009017 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.celrep.2020.107952") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-018-0081-y") Annotation(oboInOwl:hasDbXref "DOI:10.1073/pnas.1607327113") terms:description obo:CL_0009017 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.celrep.2020.107952") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-018-0081-y") Annotation(oboInOwl:hasDbXref "DOI:10.1073/pnas.1607327113") terms:description obo:CL_0009017 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Intestinal crypt stem cells of the small intestine are a type of adult stem cell intimately involved in the continuous replenishment of the intestinal epithelium, the innermost layer of the intestine responsible for nutrient absorption. These cells, located within the crypts of Lieberkühn, are the origin of various cell lineages that make up the functional units of the small intestine. They possess self-renewal ability, an essential feature of stem cells, which allows them to maintain a steady population in the small intestine.
One of the critical roles of intestinal crypt stem cells is to drive the continual renewal process taking place in the small intestine every 3-5 days. By proliferating intensively, these cells produce transient amplifying (TA) cells that are characterized by quick division and progressive differentiation. These cells eventually differentiate into specialized cell types, encompassing absorptive enterocytes, mucin-secreting goblet cells, hormone-secreting enteroendocrine cells, and Paneth cells, all of which have essential roles in digestion and nutrient absorption in the small intestine.
@@ -28707,6 +29142,10 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009017 "stem cell of small
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009017 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009017 pato:location_grouping)
AnnotationAssertion(rdfs:label obo:CL_0009017 "intestinal crypt stem cell of small intestine")
+AnnotationAssertion(Annotation(dc:license "http://creativecommons.org/licenses/by/4.0/") Annotation(rdfs:comment "Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).
+
+ISC: Intestinal Stem Cell
+TA: Transit Amplifying Cells") foaf:depiction obo:CL_0009017 )
EquivalentClasses(obo:CL_0009017 ObjectIntersectionOf(obo:CL_0002250 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001241)))
SubClassOf(obo:CL_0009017 obo:CL_0002250)
SubClassOf(obo:CL_0009017 obo:CL_0002254)
@@ -28749,7 +29188,7 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0009020 pato:location_grouping)
AnnotationAssertion(rdfs:label obo:CL_0009020 "tuft cell of appendix")
EquivalentClasses(obo:CL_0009020 ObjectIntersectionOf(obo:CL_0019032 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001154)))
SubClassOf(obo:CL_0009020 obo:CL_0002203)
-SubClassOf(obo:CL_0009020 obo:CL_1000405)
+SubClassOf(obo:CL_0009020 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001154))
# Class: obo:CL_0009021 (stromal cell of lamina propria of large intestine)
@@ -28791,9 +29230,9 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "http://orcid.org/0000-0003-41
AnnotationAssertion(terms:contributor obo:CL_0009024 )
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009024 pato:location_grouping)
AnnotationAssertion(rdfs:label obo:CL_0009024 "mesothelial cell of small intestine")
-EquivalentClasses(obo:CL_0009024 ObjectIntersectionOf(obo:CL_0000077 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002108)))
+EquivalentClasses(obo:CL_0009024 ObjectIntersectionOf(obo:CL_0000077 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001206)))
SubClassOf(obo:CL_0009024 obo:CL_0000077)
-SubClassOf(obo:CL_0009024 obo:CL_0002254)
+SubClassOf(obo:CL_0009024 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001206))
# Class: obo:CL_0009025 (mesothelial cell of colon)
@@ -28802,9 +29241,9 @@ AnnotationAssertion(terms:contributor obo:CL_0009025 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.immuni.2022.08.005") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.jcmgh.2021.08.021") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-019-0172-4") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-023-00769-0") terms:description obo:CL_0009038 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Colon macrophages are a heterogeneous population of macrophages in the gastrointestinal tract. Intestinal macrophages represent the largest group of macrophages in the body and play a key role as sentinels for pathogen recognition and elimination. Because the gastrointestinal tract is continually exposed to a high antigenic load derived from microbes and food intake, macrophages in the intestines are crucial not only for the gut’s immune defense but also for maintaining gastrointestinal homeostasis, avoiding chronic inflammation despite constantly facing foreign antigens. The phenotypic profiles and cytokine production of intestinal macrophages therefore differ from conventional macrophages elsewhere in the body.
+Colon macrophages orchestrate a wide variety of immune responses. They interact with the colon’s microflora thanks to their location in the mucosal layer, thus playing an important role in shaping gut immunity. By presenting antigens, they help to activate and steer an appropriate immune response either by triggering inflammation against harmful pathogens or by supporting tolerance for beneficial microbes. Therefore, disturbances in the colon macrophage population is thought to contribute to colon-related diseases such as inflammatory bowel disease and colon cancer.
+These immune cells are versatile and multifunctional, not just limited to defensive actions. Colon macrophages interact with the enteric nervous system to regulate gut secretion and motility. They also play a crucial role in maintaining colon tissue health and integrity by contributing to tissue repair processes. This occurs either through phagocytosis of dead cells and remnants, or indirectly through the release of growth factor molecules, which stimulate cellular proliferation and differentiation necessary for tissue regeneration.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0009038 "https://cellxgene.cziscience.com/cellguide/CL_0009038")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009038 "macrophage of colon")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009038 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009038 pato:location_grouping)
@@ -28987,11 +29431,18 @@ SubClassOf(obo:CL_0009038 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000115
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876") obo:IAO_0000115 obo:CL_0009039 "A goblet cell that is located in the colon.")
AnnotationAssertion(terms:contributor obo:CL_0009039 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/mi.2015.32") Annotation(oboInOwl:hasDbXref "DOI:10.1038/mi.2016.132") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrgastro.2013.35") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41385-018-0039-y") Annotation(oboInOwl:hasDbXref "DOI:10.1073/pnas.1006451107") terms:description obo:CL_0009039 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Colon goblet cells are a subset of intestinal goblet cells that are localized in the epithelial lining of the colon. They are specialized secretory epithelial cells that are recognized by their characteristic ‘goblet’ or flask-like shape and typically have a distinctive appearance due to the accumulation of secretory vesicles in their cytoplasm.
+The primary function of goblet cells is the secretion of mucus, which is an essential substance for the protection and successful functioning of the intestinal tract. In the colon, goblet cells continuously renew the inner mucus layer, which is attached and impervious to bacteria (the outer layer of the colon is unattached and is the habitat of commensal bacteria)
+The mucus secreted by goblet cells is rich in glycoproteins known as mucins, especially MUC2, forming a complex web of molecules that comprises the foundational structure of the mucus layer. It traps and eliminates harmful bacteria, while selectively allowing beneficial microbiota to access the epithelial surface and aid in digestion and nutrient absorption. The mucus layer not only provides a provides a protective barrier against pathogen invasion, as well as mechanical damage, and the erosive effects of digestive enzymes, it also acts as a lubricant to facilitate the passage of food material.
+Colon goblet cells are also involved in regulating the local immune response within the gut, maintaining the delicate balance between necessary immune reactions to harmful pathogens and tolerance to beneficial microbiota and dietary substances. Goblet cells can modulate immune responses by presenting antigens to dendritic cells, as well as through the production of immunomodulatory molecules that can alter the behavior of immune cells. When the inner mucus layer of the colon is defective, it might be a pathophysiological mechanism for colitis and infectious diseases.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0009039 "https://cellxgene.cziscience.com/cellguide/CL_0009039")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009039 "goblet cell of colon")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009039 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009039 pato:location_grouping)
AnnotationAssertion(rdfs:label obo:CL_0009039 "colon goblet cell")
-EquivalentClasses(obo:CL_0009039 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001155)))
+EquivalentClasses(obo:CL_0009039 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000397)))
SubClassOf(obo:CL_0009039 obo:CL_0011108)
SubClassOf(obo:CL_0009039 obo:CL_1000320)
@@ -29010,13 +29461,19 @@ SubClassOf(obo:CL_0009040 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000717
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876") obo:IAO_0000115 obo:CL_0009041 "A tuft cell that is a part of the colon.")
AnnotationAssertion(terms:contributor obo:CL_0009041 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajpgi.00073.2017") Annotation(oboInOwl:hasDbXref "DOI:10.1371/journal.ppat.1010318") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2022.822867") terms:description obo:CL_0009041 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Tuft cells, also often referred to as brush cells or caveolated cells, are highly specialized sensory cells found in the colon, among other organs. They were named for their unique appearance under an electron microscope, which presents a distinctive ‘tuft-like’ morphology. They are characterized by apical microvilli, arranged in an irregular tuft that confers a dome-like shape. These cells comprise only a small fraction of the cells in the epithelial layer of the colon, making them among the least populous cell types in this region.
+Tuft cells in the colon primarily function as chemosensory cells that can sense and respond to environmental changes. These cells can detect and respond to microbial metabolites, helping initiate immune responses against potential threats.
+Recent studies have revealed that tuft cells play a role in responding to intestinal parasitic infections. When a gastrointestinal parasite infects the colon, tuft cells are activated and release the cytokine IL-25. This action increases the production of tuft cells and triggers essential Th2 immune responses to expel the parasites. Also, the removal of tuft cells has been linked to increased susceptibility to these infections. However, overactivity of tuft cells has been associated with inflammatory bowel disease, highlighting the need for a delicate balance of tuft cell function to maintain colon homeostasis.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0009041 "https://cellxgene.cziscience.com/cellguide/CL_0009041")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009041 "colon tuft cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009041 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009041 pato:location_grouping)
AnnotationAssertion(rdfs:label obo:CL_0009041 "tuft cell of colon")
EquivalentClasses(obo:CL_0009041 ObjectIntersectionOf(obo:CL_0019032 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001155)))
SubClassOf(obo:CL_0009041 obo:CL_0002203)
-SubClassOf(obo:CL_0009041 obo:CL_0011108)
+SubClassOf(obo:CL_0009041 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001155))
# Class: obo:CL_0009042 (enteroendocrine cell of colon)
@@ -29027,14 +29484,14 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0009042 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009042 pato:location_grouping)
AnnotationAssertion(rdfs:label obo:CL_0009042 "enteroendocrine cell of colon")
EquivalentClasses(obo:CL_0009042 ObjectIntersectionOf(obo:CL_0000164 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001155)))
+SubClassOf(obo:CL_0009042 obo:CL_0011108)
SubClassOf(obo:CL_0009042 obo:CL_1001516)
-SubClassOf(obo:CL_0009042 obo:CL_1001588)
# Class: obo:CL_0009043 (intestinal crypt stem cell of colon)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876") obo:IAO_0000115 obo:CL_0009043 "An intestinal crypt stem cell that is located in the colon.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:10841502") Annotation(oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876") obo:IAO_0000115 obo:CL_0009043 "An intestinal crypt stem cell that is located in the crypt of Lieberkuhn of colon.")
AnnotationAssertion(terms:contributor obo:CL_0009043 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.cell.2013.07.004") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-018-0081-y") Annotation(oboInOwl:hasDbXref "DOI:10.1073/pnas.1607327113") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1365-2184.2009.00642.x") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s12943-019-0962-x") terms:description obo:CL_0009043 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.cell.2013.07.004") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-018-0081-y") Annotation(oboInOwl:hasDbXref "DOI:10.1073/pnas.1607327113") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1365-2184.2009.00642.x") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s12943-019-0962-x") terms:description obo:CL_0009043 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Intestinal crypt stem cells of the colon, also known as colon crypt base columnar (CBC) cells, are highly specialized cells primarily responsible for the constant self-renewal of the colonic epithelium. These cells are found in the crypts of Lieberkühn - deeply invaginated sections of the colon's mucosal layer.
The prime function of intestinal crypt stem cells of the colon is to serve as the source of constant cell regeneration in the colon. Every few days, these stem cells divide and differentiate into the various other types of intestinal cells, such as enterocytes, goblet cells, and enteroendocrine cells.
@@ -29043,9 +29500,9 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0009043 "https://cellxgene.cziscie
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009043 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009043 pato:location_grouping)
AnnotationAssertion(rdfs:label obo:CL_0009043 "intestinal crypt stem cell of colon")
-EquivalentClasses(obo:CL_0009043 ObjectIntersectionOf(obo:CL_0002250 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001155)))
-SubClassOf(obo:CL_0009043 obo:CL_0002250)
-SubClassOf(obo:CL_0009043 obo:CL_0011108)
+EquivalentClasses(obo:CL_0009043 ObjectIntersectionOf(obo:CL_0002250 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0013485)))
+SubClassOf(obo:CL_0009043 obo:CL_0009016)
+SubClassOf(obo:CL_0009043 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0013485))
# Class: obo:CL_0009044 (lymphocyte of small intestine lamina propria)
@@ -29060,6 +29517,10 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009044 "small intestine lam
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009044 pato:location_grouping)
AnnotationAssertion(rdfs:comment obo:CL_0009044 "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.")
AnnotationAssertion(rdfs:label obo:CL_0009044 "lymphocyte of small intestine lamina propria")
+AnnotationAssertion(Annotation(dc:license "http://creativecommons.org/licenses/by/4.0/") Annotation(rdfs:comment "Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).
+
+ISC: Intestinal Stem Cell
+TA: Transit Amplifying Cells") foaf:depiction obo:CL_0009044 )
EquivalentClasses(obo:CL_0009044 ObjectIntersectionOf(obo:CL_0000542 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001238)))
SubClassOf(obo:CL_0009044 obo:CL_0000542)
SubClassOf(obo:CL_0009044 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001238))
@@ -29197,8 +29658,8 @@ AnnotationAssertion(terms:contributor obo:CL_0009056 )
EquivalentClasses(obo:CL_0009080 ObjectIntersectionOf(obo:CL_0019032 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002108)))
SubClassOf(obo:CL_0009080 obo:CL_0002254)
SubClassOf(obo:CL_0009080 obo:CL_0019032)
+SubClassOf(obo:CL_0009080 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001902))
# Class: obo:CL_0009081 (specified double negative thymocyte (Homo sapiens))
@@ -29518,9 +29984,9 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009084 "endometrial glandul
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009084 pato:location_grouping)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009084 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0009084 "epithelial cell of endometrial gland")
-EquivalentClasses(obo:CL_0009084 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002451)))
+EquivalentClasses(obo:CL_0009084 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0012276)))
SubClassOf(obo:CL_0009084 obo:CL_0002149)
-SubClassOf(obo:CL_0009084 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002451))
+SubClassOf(obo:CL_0009084 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0012276))
# Class: obo:CL_0009085 (colony forming unit – Hill cell)
@@ -29575,10 +30041,12 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009089 "pulmonary pericyte"
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009089 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009089 pato:location_grouping)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009089 core:human_reference_atlas)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_0009089 "The marker set HIGD1B, KCNK3 can identify the Human cell type lung pericyte in the Lung with a confidence of 0.84 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_0009089 "lung pericyte")
EquivalentClasses(obo:CL_0009089 ObjectIntersectionOf(obo:CL_0000669 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002048)))
SubClassOf(obo:CL_0009089 obo:CL_0000669)
SubClassOf(obo:CL_0009089 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002048))
+SubClassOf(obo:CL_0009089 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000047))
# Class: obo:CL_0009090 (endothelial colony forming cell)
@@ -29646,7 +30114,12 @@ SubClassOf(obo:CL_0009094 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000163
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876") Annotation(oboInOwl:hasDbXref "https://orcid.org/0000-0003-4183-8865") obo:IAO_0000115 obo:CL_0009095 "An endothelial cell that is part of a uterus.")
AnnotationAssertion(terms:contributor obo:CL_0009095 )
AnnotationAssertion(terms:date obo:CL_0009095 "2021-12-13T14:39:25Z"^^xsd:dateTime)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/cphy.c190015") Annotation(oboInOwl:hasDbXref "DOI:10.1111/aji.12128") Annotation(oboInOwl:hasDbXref "DOI:10.1172/jci.insight.163422") Annotation(oboInOwl:hasDbXref "DOI:10.1530/REP-09-0147") Annotation(oboInOwl:hasDbXref "DOI:10.2174/1570161111311050010") terms:description obo:CL_0009095 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+The endothelial cell of the uterus is a specialized type of endothelial cell found in the inner lining of blood vessels, specifically those in the uterus. These cells play critical roles in maintaining uterine health, fertilization, and pregnancy processes. They form the interior surface of blood vessels, creating a barrier between the vessel lumen and surrounding tissue. This fluid environment, maintained by these endothelial cells, provides a platform for the material exchange between blood and tissues, thereby modulating blood coagulation, immune responses, and controlling vasodilation and vasoconstriction.
+Functionally, the endothelial cells of the uterus are paramount in regulating the uterine blood flow, an important determinant of successful conception and pregnancy outcomes. They support the vascular changes during the reproductive cycle, particularly the spiral arteriolar development and function, essential in endometrial thickening, maturation, and eventual shedding during menstruation periods. The cells also contribute to angiogenesis, a process crucial during implantation and placenta development, whereby new blood vessels form from pre-existing vessels to supply the growing fetus with oxygen and nutrients. Uterine endothelial cells are also implicated in mediating immune responses within the uterus. Changes in these cells can influence various conditions such as reproductive disorders and complications including heavy menstrual bleeding, endometrial hyperplasia, fertility problems, and cancer.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0009095 "EFO:0010711")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0009095 "https://cellxgene.cziscience.com/cellguide/CL_0009095")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009095 "uterine endothelial cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009095 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0009095 pato:location_grouping)
@@ -30004,6 +30477,12 @@ SubClassOf(obo:CL_0010007 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000414
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_0010008 "Any endothelial cell that is part of some heart.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0010008 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00441-021-03471-2") Annotation(oboInOwl:hasDbXref "DOI:10.1530/VB-20-0006") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fcvm.2018.00101") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2018.00382") Annotation(oboInOwl:hasDbXref "DOI:10.3390/ijms20184411") terms:description obo:CL_0010008 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Cardiac endothelial cells are a specialized subset of endothelial cells, the cell type responsible for forming the inner lining of cardiovascular structures such as the heart, and blood vessels. They are a pivotal component of the heart's microenvironment and play a key role in regulating blood pressure, maintaining cardiac homeostasis, in addition to cooperating with other cardiac cells like cardiomyocytes and fibroblasts in the orchestration of a coordinated heart function.
+Cardiac endothelial cells contribute to the each stage of the heart's operation, whether during relaxation or contraction. Cardiac endothelial cells release nitric oxide, a potent vasodilator that regulates blood vessel dilation consequently controlling blood pressure and flow. They also produce a myriad of growth factors that aid in new blood vessel formation, known as angiogenesis, crucially needed for tissue repair and regeneration when the heart undergoes damage, as in cases of myocardial infarction.
+Furthermore, cardiac endothelial cells control the passage of nutrients, hormones, and gases between the bloodstream and the heart tissue, ensuring its complex metabolic demands are met adequately. They serve as a selective barrier, regulating the transit of cells and signaling molecules, thereby playing a pivotal role in inflammatory responses and immune cell trafficking. They also contribute to the maintenance of blood fluidity and clotting balance through a complex interplay of anti-thrombic and pro-thrombic factors.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0010008 "https://cellxgene.cziscience.com/cellguide/CL_0010008")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0010008 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0010008 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0010008 "cardiac endothelial cell")
@@ -30054,7 +30533,7 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0010012 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0010012 "cerebral cortex neuron")
AnnotationAssertion(rdfs:seeAlso obo:CL_0010012 "https://github.com/obophenotype/cell-ontology/issues/1359")
EquivalentClasses(obo:CL_0010012 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000956)))
-SubClassOf(obo:CL_0010012 obo:CL_2000029)
+SubClassOf(obo:CL_0010012 obo:CL_0012001)
SubClassOf(obo:CL_0010012 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000956))
# Class: obo:CL_0010013 (type I pinealocyte)
@@ -30115,8 +30594,8 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_0010022 cl:cellxgene_subset)
AnnotationAssertion(rdfs:comment obo:CL_0010022 "This term is used in 3 GO terms that were created as part of the heart development focus project.")
AnnotationAssertion(rdfs:label obo:CL_0010022 "cardiac neuron")
AnnotationAssertion(rdfs:seeAlso obo:CL_0010022 "https://github.com/obophenotype/cell-ontology/pull/1488")
-EquivalentClasses(obo:CL_0010022 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000948)))
-SubClassOf(obo:CL_0010022 obo:CL_0000540)
+EquivalentClasses(obo:CL_0010022 ObjectIntersectionOf(obo:CL_2000032 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000948)))
+SubClassOf(obo:CL_0010022 obo:CL_2000032)
SubClassOf(obo:CL_0010022 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000948))
# Class: obo:CL_0011000 (dorsal horn interneuron)
@@ -30125,12 +30604,13 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:nv") obo:IAO_0000115 obo:
AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_0011000 "dorsal spinal cord interneuron")
AnnotationAssertion(rdfs:label obo:CL_0011000 "dorsal horn interneuron")
EquivalentClasses(obo:CL_0011000 ObjectIntersectionOf(obo:CL_0000099 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002256)))
+SubClassOf(obo:CL_0011000 obo:CL_0002611)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0011000 obo:CL_0005000)
-SubClassOf(obo:CL_0011000 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002256))
# Class: obo:CL_0011001 (spinal cord motor neuron)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:nv") obo:IAO_0000115 obo:CL_0011001 "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0011001 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0011001 "spinal cord motor neuron")
EquivalentClasses(obo:CL_0011001 ObjectIntersectionOf(obo:CL_0000100 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002240)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0011001 obo:CL_0000100)
@@ -30152,14 +30632,20 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0011003 "ILX:0107463")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0011003 "magnocellular neuron")
AnnotationAssertion(rdfs:label obo:CL_0011003 "magnocellular neurosecretory cell")
SubClassOf(obo:CL_0011003 obo:CL_0000165)
-SubClassOf(obo:CL_0011003 obo:CL_2000029)
+SubClassOf(obo:CL_0011003 obo:CL_0012001)
SubClassOf(obo:CL_0011003 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0001898))
# Class: obo:CL_0011004 (lens fiber cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GO:0070307") Annotation(oboInOwl:hasDbXref "GOC:nv") obo:IAO_0000115 obo:CL_0011004 "A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0011004 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.exer.2016.03.016") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.pbiomolbio.2003.11.012") Annotation(oboInOwl:hasDbXref "DOI:10.1098/rstb.2010.0300") Annotation(oboInOwl:hasDbXref "DOI:10.1242/dev.107953") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/immunology-and-microbiology/lens-fiber") terms:description obo:CL_0011004 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Lens fiber cells are specialized, elongated cells located in the ocular lens, an important part of the eye responsible for focusing light onto the retina to create clear defined images. These cells are unique among body cells, as they are transparent and filled with a clear protein called crystallin to facilitate the passage of light.
+The entire life cycle of a lens fiber cell includes differentiation from lens epithelial cells, which are the progenitor cells lying at the anterior surface of the lens. In response to various signals, these cells elongate and migrate towards the posterior pole, while simultaneously undergoing a process of denucleation and degradation of cellular organelles. This unique process ensures that the cells do not scatter light, which is critical for the transparency of the lens. After reaching full maturity, lens fiber cells form tightly packed layers, known as laminae, to make up the distinctive architecture of the ocular lens.
+Lens fiber cells play pivotal roles in vision. Their primary function is to transmit and focus the light that enters the eye onto the retina, providing the sharpness and clarity necessary for vision. The precise alignment and organization of these cells allow for optimal light transmittance and minimizes scattering, thereby maintaining the transparency of the lens. As such, disruptions or abnormalities in lens fiber cells can lead to serious vision impairment, including conditions like cataracts, a common condition characterized by the opacification of the lens.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0011004 "ZFA:0009401")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0011004 "https://cellxgene.cziscience.com/cellguide/CL_0011004")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0011004 "lens fibre cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0011004 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0011004 core:human_reference_atlas)
@@ -30169,9 +30655,8 @@ SubClassOf(obo:CL_0011004 obo:CL_0002222)
# Class: obo:CL_0011005 (GABAergic interneuron)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:CellBLAST") Annotation(oboInOwl:hasDbXref "GOC:nv") Annotation(oboInOwl:hasDbXref "PMID:29724907") obo:IAO_0000115 obo:CL_0011005 "An interneuron that uses GABA as a vesicular neurotransmitter. These interneurons are inhibitory")
-AnnotationAssertion(obo:RO_0002175 obo:CL_0011005 obo:NCBITaxon_9606)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0011005 "GABAergic inhibitory interneuron")
-AnnotationAssertion(oboInOwl:inSubset obo:CL_0011005 core:human_reference_atlas)
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0011005 cl:cellxgene_subset)
AnnotationAssertion(rdfs:comment obo:CL_0011005 "The formal and textual definitions of this term will need to be altered if evidence for non-inhibitory GABA-ergic neurons emerges.")
AnnotationAssertion(rdfs:label obo:CL_0011005 "GABAergic interneuron")
EquivalentClasses(obo:CL_0011005 ObjectIntersectionOf(obo:CL_0000099 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061534)))
@@ -30181,6 +30666,7 @@ SubClassOf(obo:CL_0011005 obo:CL_0000617)
# Class: obo:CL_0011006 (Lugaro cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:nv") obo:IAO_0000115 obo:CL_0011006 "An inhibitory GABAergic interneuron found in the cerebellar cortex.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34194302") oboInOwl:hasRelatedSynonym obo:CL_0011006 "globular cell")
AnnotationAssertion(rdfs:label obo:CL_0011006 "Lugaro cell")
SubClassOf(obo:CL_0011006 obo:CL_4023057)
@@ -30211,19 +30697,21 @@ SubClassOf(obo:CL_0011009 obo:CL_0011008)
# Class: obo:CL_0011010 (lateral mesodermal cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:NV") Annotation(oboInOwl:hasDbXref "PMID:9169844") obo:IAO_0000115 obo:CL_0011010 "A cell derived from the mesoderm that is found at the periphery of the embryo.")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0011010 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0011010 "lateral mesodermal cell")
SubClassOf(obo:CL_0011010 obo:CL_0000222)
# Class: obo:CL_0011011 (intermediate mesodermal cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:NV") Annotation(oboInOwl:hasDbXref "ISBN:978-0-87969-707-5") obo:IAO_0000115 obo:CL_0011011 "A cell derived from the mesoderm that is located between the paraxial mesoderm and the lateral plate.")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0011011 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0011011 "intermediate mesodermal cell")
SubClassOf(obo:CL_0011011 obo:CL_0000222)
# Class: obo:CL_0011012 (neural crest cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432") Annotation(oboInOwl:hasDbXref "https://orcid.org/0000-0002-9900-7880") obo:IAO_0000115 obo:CL_0011012 "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/dvg.23276") Annotation(oboInOwl:hasDbXref "DOI:10.1242/dev.193193") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fcell.2020.00635/full") Annotation(oboInOwl:hasDbXref "https://doi.org/10.1016/j.ydbio.2011.12.042") terms:description obo:CL_0011012 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/dvg.23276") Annotation(oboInOwl:hasDbXref "DOI:10.1242/dev.193193") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fcell.2020.00635/full") Annotation(oboInOwl:hasDbXref "https://doi.org/10.1016/j.ydbio.2011.12.042") terms:description obo:CL_0011012 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Neural crest cells are a group of transient and highly migratory cells that originate from the neuroectoderm during the early stages of embryonic development. They are multipotent cells with an exceptional degree of plasticity, capable of differentiating into various somatic cell types and therefore play a fundamental role in the formation of various organs and tissues, making them critical contributors to the developing embryo.
After the initiation of neurulation (the formation of the neural tube) neural crest cells start to undergo epithelial-to-mesenchymal transition and delaminate and migrate from the dorsal neural tube to several regions throughout the embryo. They differentiate into a range of diverse cell types, such as neurons and glial cells of the peripheral nervous system, including sensory and autonomic neurons. They also contribute to the formation of adrenal glands, pigment cells in the skin (melanocytes), cardiac structures, including parts of the heart septum and major arteries, as well as bones and cartilage of the face and skull.
@@ -30330,7 +30818,6 @@ AnnotationAssertion(rdfs:comment obo:CL_0011023 "Mast cells do not normally expr
AnnotationAssertion(rdfs:label obo:CL_0011023 "CD25+ mast cell")
EquivalentClasses(obo:CL_0011023 ObjectIntersectionOf(obo:CL_0001063 ObjectSomeValuesFrom(obo:RO_0001000 obo:CL_0000097) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001380)))
SubClassOf(obo:CL_0011023 obo:CL_0001063)
-SubClassOf(obo:CL_0011023 obo:PR_000050567)
SubClassOf(obo:CL_0011023 ObjectSomeValuesFrom(obo:RO_0001000 obo:CL_0000097))
SubClassOf(obo:CL_0011023 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001380))
@@ -30372,6 +30859,12 @@ SubClassOf(obo:CL_0011026 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000034))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:28369879") Annotation(oboInOwl:hasDbXref "https://orcid.org/0000-0001-6164-0667") obo:IAO_0000115 obo:CL_0011027 "Any fibroblast that is part of skeletal muscle tissue.")
AnnotationAssertion(terms:contributor obo:CL_0011027 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.diff.2016.05.007") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s13578-021-00579-4") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s13578-022-00856-w") terms:description obo:CL_0011027 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Skeletal muscle fibroblasts (SMFs), with their spindle-shaped morphology, play a crucial role in maintaining the structure and function of skeletal muscles. They produce connective tissues enveloping muscle fibers, offering vital structural support for optimal muscle contraction. SMFs are integral components of the dynamic and complex microenvironment of muscle tissue, contributing significantly to healthy muscle development and homeostasis.
+SMFs primarily synthesize and secrete extracellular matrix (ECM) components, such as collagen, fibronectin, and proteoglycans. The resulting ECM exhibits mechanical properties that resist tensile forces from muscle contractions, ensuring muscle efficiency. It also crucially transmits force during muscle movement, aids muscle attachment to the skeletal structure, and serves as a scaffold for muscle regeneration and repair.
+Following injury, they proliferate and transform into myofibroblasts, aiding wound contraction and depositing new ECM for tissue repair. Additionally, these fibroblasts modulate inflammatory responses by secreting cytokines and interact with other cell types, like immune cells and satellite cells, to coordinate muscle healing. In diseases, an imbalance in SMF activity may lead to conditions such as fibrosis, marked by excessive ECM deposition and impaired muscle function.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0011027 "https://cellxgene.cziscience.com/cellguide/CL_0011027")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0011027 "skeleton muscle fibroblast")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0011027 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0011027 "skeletal muscle fibroblast")
@@ -30385,6 +30878,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:22456085") obo:IAO_00001
AnnotationAssertion(terms:contributor obo:CL_0011028 )
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0011028 "BTO:0002771")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0011028 "OEC")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0011028 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0011028 "olfactory ensheathing cell")
SubClassOf(obo:CL_0011028 obo:CL_0000125)
@@ -30417,6 +30911,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "BTO:0002900") Annotation(oboI
AnnotationAssertion(obo:RO_0002175 obo:CL_0011031 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0011031 )
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0011031 "MDDC cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0011031 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0011031 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0011031 "monocyte-derived dendritic cell")
SubClassOf(obo:CL_0011031 obo:CL_0000782)
@@ -30442,6 +30937,12 @@ SubClassOf(obo:CL_0011100 obo:CL_0000540)
# Class: obo:CL_0011101 (chorionic trophoblast cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:NV") obo:IAO_0000115 obo:CL_0011101 "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00018-019-03104-6") Annotation(oboInOwl:hasDbXref "DOI:10.1093/biolre/ioy070") Annotation(oboInOwl:hasDbXref "DOI:10.1155/2014/579279") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK53245/") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/medicine-and-dentistry/placenta-development") terms:description obo:CL_0011101 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+The chorionic trophoblast cell, vital for placental development in mammals, originates from the blastocyst's outer layer, the trophectoderm. As a significant component of the placenta, the chorion forms the external fetal-maternal interface and consists primarily of chorionic trophoblast cells. These cells are pivotal in embryogenesis, fetal nutrition, waste removal, and immune response generation, contributing crucially to the success of pregnancy.
+Chorionic trophoblast cells undergo trophoblast differentiation, giving rise to specialized sub-types: cytotrophoblasts and syncytiotrophoblasts. Cytotrophoblasts, found in the inner layer, serve as stem cells and contribute to proliferative activities. In contrast, syncytiotrophoblasts, originating from cytotrophoblasts, form the outer layer with a distinctive multinucleated, continuous, and non-proliferative structure. These cells play a key role in maternal-fetal gas and nutrient exchange, producing essential hormones like human chorionic gonadotropin (hCG), progesterone, and estrogen, vital for sustaining pregnancy.
+Apart from their physiological roles, chorionic trophoblast cells play a crucial role in shielding the fetus from the maternal immune system. They accomplish this by modifying the expression of major histocompatibility complex (MHC) molecules, which are self-identifying proteins utilized by the immune system to identify foreign cells. Through selective expression of specific types of these molecules, trophoblast cells can evade cytotoxic T cells that might otherwise attack them, while still retaining the ability to attract natural killer cells. These natural killer cells assist in trophoblast invasion and the remodeling of blood vessels in the uterus.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0011101 "https://cellxgene.cziscience.com/cellguide/CL_0011101")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0011101 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0011101 "chorionic trophoblast cell")
EquivalentClasses(obo:CL_0011101 ObjectIntersectionOf(obo:CL_0000351 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003124)))
@@ -30452,6 +30953,7 @@ SubClassOf(obo:CL_0011101 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000312
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:NV") Annotation(oboInOwl:hasDbXref "isbn:0080923437") obo:IAO_0000115 obo:CL_0011102 "Parasympathetic neurons are part of the parasympathetic nervous sysem and the cell bodies lie in the brain and sacral region of the spinal cord. The neurons are mainly cholinergic.")
AnnotationAssertion(Annotation(sssom:mapping_justification ) oboInOwl:hasDbXref obo:CL_0011102 "ZFA:0005776")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0011102 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0011102 "parasympathetic neuron")
SubClassOf(obo:CL_0011102 obo:CL_0000107)
@@ -30516,7 +31018,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:NV") obo:IAO_0000115 obo:
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0011108 "colonic epithelial cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0011108 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0011108 "colon epithelial cell")
-EquivalentClasses(obo:CL_0011108 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001155)))
+EquivalentClasses(obo:CL_0011108 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000397)))
SubClassOf(obo:CL_0011108 obo:CL_0002253)
SubClassOf(obo:CL_0011108 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000397))
@@ -30561,9 +31063,10 @@ AnnotationAssertion(owl:deprecated obo:CL_0011112 "true"^^xsd:boolean)
# Class: obo:CL_0011113 (spiral ganglion neuron)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:NV") obo:IAO_0000115 obo:CL_0011113 "Neuron found in the spiral ganglion.")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0011113 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0011113 "spiral ganglion neuron")
-EquivalentClasses(obo:CL_0011113 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000395)))
-SubClassOf(obo:CL_0011113 obo:CL_0000540)
+EquivalentClasses(obo:CL_0011113 ObjectIntersectionOf(obo:CL_2000032 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000395)))
+SubClassOf(obo:CL_0011113 obo:CL_2000032)
SubClassOf(obo:CL_0011113 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000395))
# Class: obo:CL_0011114 (segmented neutrophil of bone marrow)
@@ -30604,8 +31107,7 @@ AnnotationAssertion(terms:contributor obo:CL_0012001 ) oboInOwl:hasDbXref obo:CL_0015000 "ZFA:0005730")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0015000 "cranial motoneuron")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0015000 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0015000 "cranial motor neuron")
SubClassOf(obo:CL_0015000 obo:CL_0000100)
@@ -30632,7 +31135,7 @@ SubClassOf(obo:CL_0015000 obo:CL_0000100)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30069044") Annotation(oboInOwl:hasDbXref "PMID:30069046") obo:IAO_0000115 obo:CL_0017000 "An ionocyte that is part of the lung epithelium. The cells from this type are major sources of the CFTR protein in human and mice.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0017000 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0017000 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41586-018-0393-7") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-pathol-042420-094031") Annotation(oboInOwl:hasDbXref "DOI:10.1172/JCI171268") terms:description obo:CL_0017000 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41586-018-0393-7") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-pathol-042420-094031") Annotation(oboInOwl:hasDbXref "DOI:10.1172/JCI171268") terms:description obo:CL_0017000 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
The pulmonary ionocyte is a relatively newly identified, specific epithelial cell type found primarily in the pulmonary or respiratory system. Discovered through novel mapping techniques in 2018, these cells are surprisingly rare, making up less than 2% of the cells in the lung's airway, yet they play an essential role in the airway surface liquid and mucus regulation, a crucial factor in lung health.
The main responsibility of the pulmonary ionocyte pertains to the regulation and mobilization of chloride ions. They express a high level of CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, which encodes a protein channel across the membrane of cells that produce mucus, sweat, saliva, tears, and digestive enzymes. The activity of CFTR regulates the movement of chloride ions and fluids in and out of cells, which helps maintain a balance of fluid in the organs they are expressed in. If CFTR is dysfunctional, it can cause conditions such as cystic fibrosis, characterized by thick, sticky mucus that can clog the lungs and obstruct the pancreas, leading to respiratory and digestive issues.
@@ -30640,15 +31143,18 @@ The discovery of this cell type offers new doors to the treatment and further un
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0017000 "https://cellxgene.cziscience.com/cellguide/CL_0017000")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0017000 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0017000 core:human_reference_atlas)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_0017000 "The marker set ASCL3, BSND can identify the Human cell type pulmonary ionocyte in the Lung with a confidence of 0.82 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_0017000 "pulmonary ionocyte")
EquivalentClasses(obo:CL_0017000 ObjectIntersectionOf(obo:CL_0005006 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000115)))
SubClassOf(obo:CL_0017000 obo:CL_0000082)
SubClassOf(obo:CL_0017000 obo:CL_0005006)
+SubClassOf(obo:CL_0017000 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000032))
# Class: obo:CL_0017001 (splanchnic mesodermal cell)
AnnotationAssertion(obo:IAO_0000115 obo:CL_0017001 "A mesodermal cell that is part of the splanchnic layer of lateral plate mesoderm.")
AnnotationAssertion(terms:contributor obo:CL_0017001 )
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0017001 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_0017001 "splanchnic mesodermal cell")
SubClassOf(obo:CL_0017001 obo:CL_0011010)
SubClassOf(obo:CL_0017001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004872))
@@ -30657,19 +31163,20 @@ SubClassOf(obo:CL_0017001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000487
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33842835") Annotation(oboInOwl:hasDbXref "http://orcid.org/0000-0001-7772-9578") obo:IAO_0000115 obo:CL_0017002 "A neuroendocrine cell that is part of the prostate epithelium.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0017002 obo:NCBITaxon_9606)
-AnnotationAssertion(oboInOwl:created_by obo:CL_0017002 )
+AnnotationAssertion(terms:contributor obo:CL_0017002 )
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0017002 "neuroendocrine cell of prostate epithelium")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0017002 "neuroendocrine cell of the prostate")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0017002 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0017002 "prostate neuroendocrine cell")
EquivalentClasses(obo:CL_0017002 ObjectIntersectionOf(obo:CL_0000165 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000428)))
+SubClassOf(obo:CL_0017002 obo:CL_0000150)
SubClassOf(obo:CL_0017002 obo:CL_0000165)
SubClassOf(obo:CL_0017002 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000428))
# Class: obo:CL_0017003 (epithelial cell of prostatic urethra)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30566875") obo:IAO_0000115 obo:CL_0017003 "An epithelial cell that is part of the prostatic urethra.")
-AnnotationAssertion(oboInOwl:created_by obo:CL_0017003 )
+AnnotationAssertion(terms:contributor obo:CL_0017003 )
AnnotationAssertion(rdfs:label obo:CL_0017003 "epithelial cell of prostatic urethra")
EquivalentClasses(obo:CL_0017003 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001335)))
SubClassOf(obo:CL_0017003 obo:CL_1000296)
@@ -30679,7 +31186,7 @@ SubClassOf(obo:CL_0017003 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000133
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MESH:D000067170") Annotation(oboInOwl:hasDbXref "PMID:20367664") Annotation(oboInOwl:hasDbXref "PMID:28714595") Annotation(oboInOwl:hasDbXref "PMID:31311805") Annotation(oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/Telocyte") obo:IAO_0000115 obo:CL_0017004 "A supportive cell with a small, oval-shaped body and one to five telopodes. Telopodes are cytoplasmic protrusions from tens to hundreds of micrometers long and mostly below 0.2 microns of caliber.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0017004 obo:NCBITaxon_9606)
-AnnotationAssertion(oboInOwl:created_by obo:CL_0017004 )
+AnnotationAssertion(terms:contributor obo:CL_0017004 )
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20367664") oboInOwl:hasNarrowSynonym obo:CL_0017004 "interstitial Cajal cell-like cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20367664") oboInOwl:hasNarrowSynonym obo:CL_0017004 "interstitial Cajal-like cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20367664") oboInOwl:hasRelatedSynonym obo:CL_0017004 "ICLC")
@@ -30693,8 +31200,8 @@ SubClassOf(obo:CL_0017004 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0120327))
# Class: obo:CL_0017005 (lymphoblast)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "NCIT:C13013") Annotation(oboInOwl:hasDbXref "http://orcid.org/0000-0001-9990-8331") obo:IAO_0000115 obo:CL_0017005 "A lymphocyte that has gotten larger after being stimulated by an antigen.")
-AnnotationAssertion(dc:date obo:CL_0017005 "2022-08-17T14:20:01Z")
-AnnotationAssertion(oboInOwl:created_by obo:CL_0017005 )
+AnnotationAssertion(terms:contributor obo:CL_0017005 )
+AnnotationAssertion(terms:date obo:CL_0017005 "2022-08-17T14:20:01Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0017005 "BTO:0000772")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0017005 "EFO:0000572")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0017005 "FMA:83030")
@@ -30706,8 +31213,8 @@ SubClassOf(obo:CL_0017005 ObjectSomeValuesFrom(obo:RO_0002353 obo:GO_0046649))
# Class: obo:CL_0017006 (B-lymphoblast)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "EFO:0005293") Annotation(oboInOwl:hasDbXref "https://orcid.org/0000-0002-2825-0621") obo:IAO_0000115 obo:CL_0017006 "A lymphocyte of B lineage that has gotten larger after being stimulated by an antigen.")
-AnnotationAssertion(dc:date obo:CL_0017006 "2022-08-17T14:30:32Z")
-AnnotationAssertion(oboInOwl:created_by obo:CL_0017006 )
+AnnotationAssertion(terms:contributor obo:CL_0017006 )
+AnnotationAssertion(terms:date obo:CL_0017006 "2022-08-17T14:30:32Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0017006 "EFO:0005293")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0017006 "FMA:83031")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0017006 cl:blood_and_immune_upper_slim)
@@ -30718,8 +31225,8 @@ SubClassOf(obo:CL_0017006 obo:CL_0017005)
# Class: obo:CL_0017009 (Axl+ dendritic cell, human)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:28428369") Annotation(oboInOwl:hasDbXref "PMID:29221729") Annotation(oboInOwl:hasDbXref "PMID:31156637") obo:IAO_0000115 obo:CL_0017009 "A human dendritic cell that expresses the AXL and SIGLEC6 genes.")
-AnnotationAssertion(dc:date obo:CL_0017009 "2022-08-25T14:18:37Z"^^xsd:dateTime)
-AnnotationAssertion(oboInOwl:created_by obo:CL_0017009 )
+AnnotationAssertion(terms:contributor obo:CL_0017009 )
+AnnotationAssertion(terms:date obo:CL_0017009 "2022-08-25T14:18:37Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0017009 "AS DC, human")
AnnotationAssertion(rdfs:label obo:CL_0017009 "Axl+ dendritic cell, human")
SubClassOf(obo:CL_0017009 obo:CL_0001056)
@@ -30850,6 +31357,11 @@ SubClassOf(obo:CL_0017509 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0002506))
AnnotationAssertion(obo:IAO_0000115 obo:CL_0019001 "Any serous secreting cell that is part of the tracheobronchial epithelium.")
AnnotationAssertion(terms:contributor obo:CL_0019001 )
AnnotationAssertion(terms:date obo:CL_0019001 "2020-05-07T16:03:27Z"^^xsd:dateTime)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.resp.2007.06.017") Annotation(oboInOwl:hasDbXref "DOI:10.1113/jphysiol.2003.052779") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev.ph.52.030190.000525") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajplung.00068.2019") terms:description obo:CL_0019001 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Serous cells of the tracheobronchial are found on the surface epithelium, submucosal glands, or both, depending on species. They appear in tubulo-acinar arrangements in submucosal glands.
+Tracheobronchial serous cells play a vital role in maintaining respiratory health by secreting serous fluid, which is rich in enzymes, ions, and antimicrobial proteins. This serous fluid is essential in clearing out debris, trapping and neutralizing inhaled pathogens and particulate matters, thereby helping in preventing infections. Their secretory products also include water and electrolytes that, combined with mucus (from mucous cells), maintain proper humidity within the airway and lubricate its surfaces, facilitating unhindered airflow. Dysfunction of these cells may lead to diseases such as cystic fibrosis.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0019001 "https://cellxgene.cziscience.com/cellguide/CL_0019001")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0019001 "serous cell of tracheobronchial tree")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0019001 cl:added_for_HCA)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0019001 cl:cellxgene_subset)
@@ -30922,6 +31434,7 @@ AnnotationAssertion(obo:RO_0002175 obo:CL_0019018 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0019018 )
AnnotationAssertion(terms:date obo:CL_0019018 "2020-07-21T12:42:48Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0019018 "smooth muscle cell of blood vessel")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_0019018 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0019018 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_0019018 "blood vessel smooth muscle cell"@en)
EquivalentClasses(obo:CL_0019018 ObjectIntersectionOf(obo:CL_0000192 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001981)))
@@ -30934,13 +31447,21 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:10853867") obo:IAO_00001
AnnotationAssertion(obo:RO_0002175 obo:CL_0019019 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0019019 )
AnnotationAssertion(terms:date obo:CL_0019019 "2020-07-21T12:50:22Z"^^xsd:dateTime)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/978-3-540-79090-7_5") Annotation(oboInOwl:hasDbXref "DOI:10.1152/japplphysiol.00950.2012") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK556044/") terms:description obo:CL_0019019 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Tracheobronchial smooth muscle cells are universally located in the tracheobronchial tree and play a critical role in controlling and modulating the size of the airway lumen, thereby contributing significantly to the airflow resistance.
+These cells display both phasic and tonic characteristics, which are vital for airway contractility. Phasic activity manifests as cyclic contraction and relaxation, similar to the behavior seen in gastrointestinal smooth muscle cells, whilst tonic activity resembles vascular smooth muscle cells, maintaining a constant degree of tension. These features enable tracheobronchial smooth muscle cells to constrict the airways in response to various mechanical and chemical stimuli, including allergens, parasympathetic nervous stimulation, changes in gas composition, and cold air, thus protecting the delicate alveoli from potential damage.
+Tracheobronchial smooth muscle cells, beyond their contractile function, actively contribute to airway remodeling in conditions like asthma. Their proliferative and synthetic capabilities lead to smooth muscle hypertrophy, hyperplasia, and the production of extracellular matrix components, collectively causing abnormal airway narrowing.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0019019 "https://cellxgene.cziscience.com/cellguide/CL_0019019")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0019019 "smooth muscle cell of tracheobronchial tree")
AnnotationAssertion(oboInOwl:inSubset obo:CL_0019019 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_0019019 core:human_reference_atlas)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_0019019 "The marker set ACTA2, TAGLN can identify the Human cell type tracheobronchial smooth muscle cell in the Lung with a confidence of 0.69 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_0019019 "tracheobronchial smooth muscle cell"@en)
EquivalentClasses(obo:CL_0019019 ObjectIntersectionOf(obo:CL_0000192 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0007196)))
SubClassOf(obo:CL_0019019 obo:CL_0000192)
SubClassOf(obo:CL_0019019 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0007196))
+SubClassOf(obo:CL_0019019 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000056))
# Class: obo:CL_0019020 (extrahepatic cholangiocyte)
@@ -31025,7 +31546,7 @@ SubClassOf(obo:CL_0019029 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_840000
# Class: obo:CL_0019031 (intestine goblet cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:1996606") Annotation(oboInOwl:hasDbXref "PMID:24942678") obo:IAO_0000115 obo:CL_0019031 "Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:1996606") Annotation(oboInOwl:hasDbXref "PMID:24942678") Annotation(oboInOwl:hasDbXref "PMID:33484640") obo:IAO_0000115 obo:CL_0019031 "Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3.")
AnnotationAssertion(terms:contributor obo:CL_0019031 )
AnnotationAssertion(terms:date obo:CL_0019031 "2020-10-14T14:59:07Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:1996606") oboInOwl:hasExactSynonym obo:CL_0019031 "intestinal goblet cell")
@@ -31034,10 +31555,11 @@ AnnotationAssertion(rdfs:label obo:CL_0019031 "intestine goblet cell"@en)
EquivalentClasses(obo:CL_0019031 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001277)))
SubClassOf(obo:CL_0019031 obo:CL_0000160)
SubClassOf(obo:CL_0019031 obo:CL_0002563)
+SubClassOf(obo:CL_0019031 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_4047017))
# Class: obo:CL_0019032 (intestinal tuft cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:22527717") obo:IAO_0000115 obo:CL_0019032 "Any brush cell that is part of the intestinal epithelium.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:22527717") Annotation(oboInOwl:hasDbXref "PMID:39358509") obo:IAO_0000115 obo:CL_0019032 "Any brush cell that is part of the intestinal epithelium.")
AnnotationAssertion(obo:RO_0002175 obo:CL_0019032 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_0019032 )
AnnotationAssertion(terms:date obo:CL_0019032 "2020-10-15T12:47:46Z"^^xsd:dateTime)
@@ -31048,6 +31570,7 @@ AnnotationAssertion(rdfs:label obo:CL_0019032 "intestinal tuft cell"@en)
EquivalentClasses(obo:CL_0019032 ObjectIntersectionOf(obo:CL_0002204 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001277)))
SubClassOf(obo:CL_0019032 obo:CL_0002204)
SubClassOf(obo:CL_0019032 obo:CL_0002563)
+SubClassOf(obo:CL_0019032 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002250))
# Class: obo:CL_0700009 (obsolete kidney collecting duct beta-intercalated cell)
@@ -31086,6 +31609,7 @@ AnnotationAssertion(owl:deprecated obo:CL_1000036 "true"^^xsd:boolean)
# Class: obo:CL_1000042 (forebrain neuroblast)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1000042 "Any neuroblast (sensu Vertebrata) that is part of some forebrain.")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_1000042 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000042 "forebrain neuroblast")
EquivalentClasses(obo:CL_1000042 ObjectIntersectionOf(obo:CL_0000031 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001890)))
SubClassOf(obo:CL_1000042 obo:CL_0000031)
@@ -31146,7 +31670,7 @@ SubClassOf(obo:CL_1000123 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000514
# Class: obo:CL_1000143 (lung goblet cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1000143 "Any goblet cell that is part of some lung epithelium.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41385-018-0039-y") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41385-020-00370-7") Annotation(oboInOwl:hasDbXref "DOI:10.1159/000512268") Annotation(oboInOwl:hasDbXref "DOI:10.1513/AnnalsATS.201802-128AW") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK553208/") terms:description obo:CL_1000143 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41385-018-0039-y") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41385-020-00370-7") Annotation(oboInOwl:hasDbXref "DOI:10.1159/000512268") Annotation(oboInOwl:hasDbXref "DOI:10.1513/AnnalsATS.201802-128AW") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK553208/") terms:description obo:CL_1000143 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Lung goblet cells are critical components of the respiratory tract, specifically found in the bronchial segments. They are secretory epithelial cells known for their signature \"goblet\" or cup-like shape. Their primary function is to produce and secrete mucus that aids in trapping airborne particles and pathogens, preventing them from reaching the delicate environment of the lung. As part of the lung's epithelial lining, they act as frontline defenders, maintaining lung health and function.
The lung goblet cells are densely packed with granules containing mucin glycoproteins, the primary component of mucus. As mucus is produced and secreted, it moves towards the lumen of the lungs where the cilia, hair-like structures of the neighboring ciliated epithelial cells, help to navigate it upwards and out of the respiratory tract. This coordinated action ensures the expulsion of unwanted particles and pathogens, effectively cleaning the respiratory tract.
@@ -31157,6 +31681,7 @@ AnnotationAssertion(rdfs:label obo:CL_1000143 "lung goblet cell")
EquivalentClasses(obo:CL_1000143 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000115)))
SubClassOf(obo:CL_1000143 obo:CL_0000082)
SubClassOf(obo:CL_1000143 obo:CL_0002370)
+SubClassOf(obo:CL_1000143 obo:CL_1000272)
# Class: obo:CL_1000147 (cardiac valve cell)
@@ -31209,27 +31734,30 @@ SubClassOf(obo:CL_1000217 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000412
# Class: obo:CL_1000222 (stomach neuroendocrine cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1000222 "Any neuroendocrine cell that is part of some stomach.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:15153415") obo:IAO_0000115 obo:CL_1000222 "A specialised neuroendocrine cell located in the gastric mucosa that regulates digestive processes including acid secretion and gut motility. This cell stores hormones in large dense core vesicles and synaptic-like microvesicles.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:15153415") oboInOwl:hasBroadSynonym obo:CL_1000222 "DES cell")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:15153415") oboInOwl:hasBroadSynonym obo:CL_1000222 "diffuse endocrine system cell")
AnnotationAssertion(rdfs:label obo:CL_1000222 "stomach neuroendocrine cell")
-EquivalentClasses(obo:CL_1000222 ObjectIntersectionOf(obo:CL_0000165 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000945)))
-SubClassOf(obo:CL_1000222 obo:CL_0000164)
+EquivalentClasses(obo:CL_1000222 ObjectIntersectionOf(obo:CL_0000165 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001276)))
SubClassOf(obo:CL_1000222 obo:CL_0000165)
-SubClassOf(obo:CL_1000222 obo:CL_0002659)
+SubClassOf(obo:CL_1000222 obo:CL_1001517)
+SubClassOf(obo:CL_1000222 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0046717))
-# Class: obo:CL_1000223 (lung neuroendocrine cell)
+# Class: obo:CL_1000223 (pulmonary neuroendocrine cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33355253") Annotation(oboInOwl:hasDbXref "doi:10.3109/01902148209069653") Annotation(oboInOwl:hasDbXref "doi:10.7554/eLife.78216") obo:IAO_0000115 obo:CL_1000223 "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33355253") Annotation(oboInOwl:hasDbXref "doi:10.3109/01902148209069653") Annotation(oboInOwl:hasDbXref "doi:10.7554/eLife.78216") obo:IAO_0000115 obo:CL_1000223 "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Pulmonary neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Pulmonary neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000223 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/bs.ctdb.2018.12.002") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.devcel.2020.09.024") Annotation(oboInOwl:hasDbXref "DOI:10.1242/dmm.046920") terms:description obo:CL_1000223 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/bs.ctdb.2018.12.002") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.devcel.2020.09.024") Annotation(oboInOwl:hasDbXref "DOI:10.1242/dmm.046920") terms:description obo:CL_1000223 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Lung neuroendocrine cells, also commonly known as pulmonary neuroendocrine cells (PNECs), are predominantly located in the respiratory epithelium of the bronchial and bronchiolar airways in the lungs. These cells, characterised by their small size and granular appearance, have a distinctive morphology that sets them apart from other lung cells. They are considered part of the diffuse neuroendocrine system due to their scattered distribution through the epithelium and have been classified into solitary cells and clustered forms known as neuroepithelial bodies.
The primary function of PNECs is linked to regulation and maintenance of the lung environment. They are sensory in nature and can secrete various bioactive substances such as serotonin, calcitonin, calcitonin gene-related peptides, and bombesin-like peptides which modulate airway smooth muscle tone and influence gut motility. For example, they act as oxygen sensors in response to hypoxia and are responsible for releasing neuropeptides that can induce responses. Moreover, PNECs provide an afferent function as they are equipped with long microvilli that project into the lumen of the bronchus and react to changes in the chemical composition of the luminal content.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000223 "https://cellxgene.cziscience.com/cellguide/CL_1000223")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33355253") oboInOwl:hasExactSynonym obo:CL_1000223 "pulmonary neuroendocrine cell")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:15018448") oboInOwl:hasExactSynonym obo:CL_1000223 "lung neuroendocrine cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33355253") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_1000223 "PNEC")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000223 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000223 core:human_reference_atlas)
-AnnotationAssertion(rdfs:label obo:CL_1000223 "lung neuroendocrine cell")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_1000223 "The marker set CHGA, GRP can identify the Human cell type lung neuroendocrine cell in the Lung with a confidence of 0.94 (NS-Forest FBeta value).")
+AnnotationAssertion(rdfs:label obo:CL_1000223 "pulmonary neuroendocrine cell")
EquivalentClasses(obo:CL_1000223 ObjectIntersectionOf(obo:CL_0000165 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002048)))
SubClassOf(obo:CL_1000223 obo:CL_0000006)
SubClassOf(obo:CL_1000223 obo:CL_0000098)
@@ -31239,6 +31767,7 @@ SubClassOf(obo:CL_1000223 obo:CL_0000458)
SubClassOf(obo:CL_1000223 obo:CL_1000272)
SubClassOf(obo:CL_1000223 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031045))
SubClassOf(obo:CL_1000223 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0070483))
+SubClassOf(obo:CL_1000223 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000043))
# Class: obo:CL_1000236 (posterior lateral line nerve glial cell)
@@ -31258,21 +31787,21 @@ SubClassOf(obo:CL_1000239 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_200042
# Class: obo:CL_1000245 (posterior lateral line ganglion neuron)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1000245 "Any neuron that has its soma located in some posterior lateral line ganglion.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1000245 "Any peripheral nervous system neuron that has its soma located in some posterior lateral line ganglion.")
AnnotationAssertion(rdfs:label obo:CL_1000245 "posterior lateral line ganglion neuron")
-EquivalentClasses(obo:CL_1000245 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_2001314)))
+EquivalentClasses(obo:CL_1000245 ObjectIntersectionOf(obo:CL_2000032 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_2001314)))
SubClassOf(obo:CL_1000245 obo:CL_2000031)
SubClassOf(obo:CL_1000245 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_2001314))
-# Class: obo:CL_1000271 (lung ciliated cell)
+# Class: obo:CL_1000271 (lung multiciliated epithelial cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:27864314") obo:IAO_0000115 obo:CL_1000271 "An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000271 obo:NCBITaxon_9606)
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000271 "lung ciliated cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000271 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000271 core:human_reference_atlas)
-AnnotationAssertion(rdfs:label obo:CL_1000271 "lung ciliated cell")
-EquivalentClasses(obo:CL_1000271 ObjectIntersectionOf(obo:CL_0000067 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000115)))
-SubClassOf(obo:CL_1000271 obo:CL_0000067)
+AnnotationAssertion(rdfs:label obo:CL_1000271 "lung multiciliated epithelial cell")
+EquivalentClasses(obo:CL_1000271 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000115) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031514) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007)))
SubClassOf(obo:CL_1000271 obo:CL_0000082)
SubClassOf(obo:CL_1000271 obo:CL_4030034)
@@ -31295,10 +31824,20 @@ SubClassOf(obo:CL_1000274 obo:CL_0000349)
# Class: obo:CL_1000275 (smooth muscle cell of small intestine)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000275 "A smooth muscle cell that is part of the small intestine.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/978-981-13-5895-1_1") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrgastro.2012.168") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-020-0271-2") Annotation(oboInOwl:hasDbXref "DOI:10.1053/j.gastro.2016.02.030") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1582-4934.2008.00352.x") terms:description obo:CL_1000275 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Smooth muscle cells of the small intestine form a key component of the enteric system which is imperative for gastrointestinal motility. These cells are a specialized subgroup of smooth muscle cells, specifically found in the layers of the small intestine. The small intestine represents a significant part of the digestive system and plays a crucial role in the absorption of nutrients into the bloodstream.
+Smooth muscle cells of the small intestine are predominantly responsible for creating the contractions and relaxations that constitute intestinal motility. They trigger these movements in a coordinated and rhythmic manner known as peristalsis and segmentation. Peristalsis is a form of longitudinal and sequential contraction that pushes food from the upper gastrointestinal tract to the lower parts. Segmentation works by squeezing the intestine randomly, thereby facilitating the mixing of food particles and increasing contact with absorptive surfaces. These two processes are critical for intestinal motility and an effective digestive process.
+Apart from facilitating transit of food through contractions, these smooth muscle cells play a role in controlling the diameter of the vessels and the blood flow in the small intestine by their constrictive ability. These smooth muscle cells also contribute to the structural integrity of the small intestine by forming a part of its muscularis externa and muscularis mucosae. Additionally, they interact with other cell types such as enteric neurons and interstitial cells of Cajal (ICC), forming an integrated cellular network that ensures optimal functioning of the intestinal tract.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000275 "FMA:15050")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000275 "https://cellxgene.cziscience.com/cellguide/CL_1000275")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:15050") oboInOwl:hasExactSynonym obo:CL_1000275 "non-striated muscle fiber of small intestine")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000275 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000275 "smooth muscle cell of small intestine")
+AnnotationAssertion(Annotation(dc:license "http://creativecommons.org/licenses/by/4.0/") Annotation(rdfs:comment "Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).
+
+ISC: Intestinal Stem Cell
+TA: Transit Amplifying Cells") foaf:depiction obo:CL_1000275 )
EquivalentClasses(obo:CL_1000275 ObjectIntersectionOf(obo:CL_0002504 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002108)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1000275 obo:CL_0002504)
SubClassOf(obo:CL_1000275 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002108))
@@ -31311,6 +31850,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:15058") oboInOwl:hasExact
AnnotationAssertion(rdfs:label obo:CL_1000276 "smooth muscle fiber of duodenum")
EquivalentClasses(obo:CL_1000276 ObjectIntersectionOf(obo:CL_1000275 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002114)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1000276 obo:CL_1000275)
+SubClassOf(obo:CL_1000276 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001902))
SubClassOf(obo:CL_1000276 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002114))
# Class: obo:CL_1000277 (smooth muscle fiber of jejunum)
@@ -31326,12 +31866,19 @@ SubClassOf(obo:CL_1000277 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000211
# Class: obo:CL_1000278 (smooth muscle fiber of ileum)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000278 "A smooth muscle cell that is part of the ileum.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1152/advan.00025.2003") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK532857/") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK556137/") terms:description obo:CL_1000278 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+The smooth muscle fiber of the ileum primarily refers to a specific class of muscle cells present in the ileum, the final segment of the small intestine. Distinguished from skeletal muscle and cardiac muscle, smooth muscle does not possess striations and is under the control of the involuntary nervous system.
+These cells primarily facilitate the movement of digested food, a process known as peristalsis. These cells coordinate rhythmic contractions and relaxations, propelling the chyme toward the colon. This process is vital for efficient nutrient absorption in the small intestine and the transfer of undigested material to the large intestine. Moreover, the smooth muscle fibers enhance the ileum's ability to expand and adapt to volume changes without elevating internal pressure, known as compliance.
+The smooth muscle fiber of the ileum contributes to reflex responses, enhancing muscle contractions to propel intestinal contents in different physiological conditions. This involves intricate molecular signaling with neurotransmitters, hormones, and local signals. Thus, beyond its structural role, the smooth muscle fiber is crucial for the physiological functions of digestion and absorption in the small intestine.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000278 "FMA:15066")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000278 "https://cellxgene.cziscience.com/cellguide/CL_1000278")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:15066") oboInOwl:hasExactSynonym obo:CL_1000278 "non-striated muscle fiber of ileum")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000278 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000278 "smooth muscle fiber of ileum")
EquivalentClasses(obo:CL_1000278 ObjectIntersectionOf(obo:CL_1000275 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002116)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1000278 obo:CL_1000275)
+SubClassOf(obo:CL_1000278 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001902))
SubClassOf(obo:CL_1000278 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002116))
# Class: obo:CL_1000279 (smooth muscle cell of large intestine)
@@ -31356,6 +31903,7 @@ AnnotationAssertion(rdfs:label obo:CL_1000280 "smooth muscle cell of colon")
EquivalentClasses(obo:CL_1000280 ObjectIntersectionOf(obo:CL_0002504 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001155)))
SubClassOf(obo:CL_1000280 obo:CL_1000279)
SubClassOf(obo:CL_1000280 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001155))
+SubClassOf(obo:CL_1000280 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001278))
# Class: obo:CL_1000281 (smooth muscle cell of cecum)
@@ -31418,6 +31966,7 @@ AnnotationAssertion(rdfs:label obo:CL_1000286 "smooth muscle cell of rectum")
EquivalentClasses(obo:CL_1000286 ObjectIntersectionOf(obo:CL_0000192 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001052)))
SubClassOf(obo:CL_1000286 obo:CL_1000279)
SubClassOf(obo:CL_1000286 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001052))
+SubClassOf(obo:CL_1000286 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001278))
# Class: obo:CL_1000287 (myocyte of anterior internodal tract)
@@ -31481,7 +32030,13 @@ AnnotationAssertion(owl:deprecated obo:CL_1000295 "true"^^xsd:boolean)
# Class: obo:CL_1000296 (epithelial cell of urethra)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000296 "An epithelial cell that is part of the urethra.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.celrep.2018.11.086") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41385-022-00565-0") Annotation(oboInOwl:hasDbXref "DOI:10.1089/ten.teb.2016.0352") Annotation(oboInOwl:hasDbXref "DOI:10.1101/2020.02.19.937615v2.full") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajprenal.00327.2009") terms:description obo:CL_1000296 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Epithelial cells of the urethra constitute the inner lining of the urethra, forming a mucosal barrier that helps protect the body from external contaminants. The type of epithelial cells found in the urethra can vary along its length. In general, the urethra is lined with stratified squamous epithelium in its distal or external portion, which is closer to the external environment. This type of epithelium provides protection against mechanical stress and pathogens. Closer to the bladder, the urethra transitions to a different type of epithelium. In males, the proximal part of the urethra is lined with pseudostratified columnar epithelium in the region where it passes through the prostate gland. In females, the transitional epithelium may be present in the proximal part of the urethra near the bladder.
+Epithelial cells of the urethra are primarily dedicated to the protection of underlying tissues from mechanical stress and pathogens during micturition (urination). They do this by creating a tight, impermeable barrier that prevents the entry and colonization of invading microbes. They produce a variety of antimicrobials and are tightly packed to prevent infiltration between cells, forming an integral part of the body's innate immune system.
+In addition to their protective role, these cells are involved in the secretion of mucus. This mucus acts as a lubricant that ensures the smooth and easy passage of urine from the bladder through the urethra and out of the body, reducing any potential damage from the erosive action of urine. Epithelial cells of the urethra are dynamic, constantly renewing their numbers to replace any cells lost through wear and tear. Any disruptions to the function or integrity of these cells may contribute to urinary tract infections and other urological disorders.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000296 "FMA:256165")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000296 "https://cellxgene.cziscience.com/cellguide/CL_1000296")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000296 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000296 "epithelial cell of urethra")
EquivalentClasses(obo:CL_1000296 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000057)))
@@ -31514,7 +32069,7 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_1000299 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000299 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_1000299 "fibroblast of connective tissue of prostate")
SubClassOf(obo:CL_1000299 obo:CL_0000057)
-SubClassOf(obo:CL_1000299 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002367))
+SubClassOf(obo:CL_1000299 obo:CL_0002622)
# Class: obo:CL_1000300 (fibroblast of outer membrane of prostatic capsule)
@@ -31522,7 +32077,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000300 "FMA:261273")
AnnotationAssertion(rdfs:label obo:CL_1000300 "fibroblast of outer membrane of prostatic capsule")
SubClassOf(obo:CL_1000300 obo:CL_0000057)
-SubClassOf(obo:CL_1000300 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002367))
+SubClassOf(obo:CL_1000300 obo:CL_0002622)
# Class: obo:CL_1000301 (fibroblast of subepithelial connective tissue of prostatic gland)
@@ -31532,7 +32087,7 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000301 "FMA:261275")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000301 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_1000301 "fibroblast of subepithelial connective tissue of prostatic gland")
SubClassOf(obo:CL_1000301 obo:CL_0000057)
-SubClassOf(obo:CL_1000301 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002367))
+SubClassOf(obo:CL_1000301 obo:CL_0002622)
# Class: obo:CL_1000302 (fibroblast of papillary layer of dermis)
@@ -31559,7 +32114,7 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000304 "FMA:261281")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000304 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000304 "fibroblast of connective tissue of nonglandular part of prostate")
SubClassOf(obo:CL_1000304 obo:CL_0000057)
-SubClassOf(obo:CL_1000304 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002367))
+SubClassOf(obo:CL_1000304 obo:CL_0002622)
# Class: obo:CL_1000305 (fibroblast of connective tissue of glandular part of prostate)
@@ -31568,17 +32123,16 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000305 "FMA:261283")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000305 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000305 "fibroblast of connective tissue of glandular part of prostate")
SubClassOf(obo:CL_1000305 obo:CL_0000057)
-SubClassOf(obo:CL_1000305 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002367))
+SubClassOf(obo:CL_1000305 obo:CL_0002622)
# Class: obo:CL_1000306 (fibroblast of tunica adventitia of artery)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000306 "A fibroblast that is part of the tunica adventitia of artery.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000306 "FMA:261285")
AnnotationAssertion(rdfs:label obo:CL_1000306 "fibroblast of tunica adventitia of artery")
-EquivalentClasses(obo:CL_1000306 ObjectIntersectionOf(obo:CL_0000057 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005734)))
-SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1000306 obo:CL_0000057)
-SubClassOf(obo:CL_1000306 obo:CL_0002503)
-SubClassOf(obo:CL_1000306 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005734))
+EquivalentClasses(obo:CL_1000306 ObjectIntersectionOf(obo:CL_0000057 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0007240)))
+SubClassOf(obo:CL_1000306 obo:CL_4052030)
+SubClassOf(obo:CL_1000306 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0007240))
# Class: obo:CL_1000307 (fibroblast of dense regular elastic tissue)
@@ -31641,13 +32195,22 @@ SubClassOf(obo:CL_1000311 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000208
# Class: obo:CL_1000312 (bronchial goblet cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000312 "A goblet cell that is part of the epithelium of bronchus.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_1000312 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/S0165-6147(00)01600-X") Annotation(oboInOwl:hasDbXref "DOI:10.1016/S1357-2725(02)00083-3") Annotation(oboInOwl:hasDbXref "DOI:10.1080/07853890600585795") Annotation(oboInOwl:hasDbXref "DOI:10.2147/COPD.S38938") terms:description obo:CL_1000312 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Bronchial goblet cells are a subset of goblet cells that are predominantly found in the respiratory tract, specifically within the bronchi and bronchioles. Named for their flask-like shape and their apparent similarity to a goblet, these cells contribute significantly to the maintenance of lung health and homeostasis. In humans, goblet cells comprise up to 25% of the bronchial epithelial columnar cells and are an integral part of the mucus-secreting system of the respiratory tract and are primarily responsible for the production and secretion of mucus.
+The mucus secreted by bronchial goblet cells serves as a protective layer over the delicate and sensitive structures of the bronchi. The mucus, an amalgamation of glycoproteins, lipids, and other substances, traps any inhaled dust, microorganisms, and pollutants, preventing them from reaching deeper lung tissues and causing potential damage. Additionally, the mucus secretion aids in moistening the airway surface, thereby facilitating effective gas exchange and maintaining the overall health of the respiratory tract.
+Bronchial goblet cells have an innate defense mechanism wherein they increase secretion of mucus in response to irritants, infection or inflammation in the airway. This strategy, however, if incessantly stimulated, can lead to airway obstruction and health complications like asthma and chronic obstructive pulmonary disease (COPD).")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000312 "FMA:263032")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000312 "https://cellxgene.cziscience.com/cellguide/CL_1000312")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:263032") oboInOwl:hasExactSynonym obo:CL_1000312 "goblet cell of epithelium of bronchus")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000312 cl:cellxgene_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_1000312 "The marker set PLCG2, ANKRD36C can identify the Human cell type bronchial goblet cell in the Lung with a confidence of 0.55 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_1000312 "bronchial goblet cell")
EquivalentClasses(obo:CL_1000312 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002185)))
SubClassOf(obo:CL_1000312 obo:CL_0002328)
SubClassOf(obo:CL_1000312 obo:CL_0019003)
+SubClassOf(obo:CL_1000312 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000026))
# Class: obo:CL_1000313 (gastric goblet cell)
@@ -31658,7 +32221,6 @@ AnnotationAssertion(rdfs:label obo:CL_1000313 "gastric goblet cell")
EquivalentClasses(obo:CL_1000313 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000945)))
SubClassOf(obo:CL_1000313 obo:CL_0000160)
SubClassOf(obo:CL_1000313 obo:CL_0002180)
-SubClassOf(obo:CL_1000313 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001276))
# Class: obo:CL_1000314 (gastric cardiac gland goblet cell)
@@ -31668,6 +32230,7 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000314 "goblet cell of epit
AnnotationAssertion(rdfs:label obo:CL_1000314 "gastric cardiac gland goblet cell")
EquivalentClasses(obo:CL_1000314 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008859)))
SubClassOf(obo:CL_1000314 obo:CL_0000152)
+SubClassOf(obo:CL_1000314 obo:CL_0002659)
SubClassOf(obo:CL_1000314 obo:CL_1000313)
SubClassOf(obo:CL_1000314 ObjectSomeValuesFrom(obo:BFO_0000050 ObjectIntersectionOf(obo:UBERON_0000483 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008859))))
@@ -31679,6 +32242,7 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000315 "goblet cell of epit
AnnotationAssertion(rdfs:label obo:CL_1000315 "principal gastric gland goblet cell")
EquivalentClasses(obo:CL_1000315 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009971)))
SubClassOf(obo:CL_1000315 obo:CL_0000152)
+SubClassOf(obo:CL_1000315 obo:CL_0002659)
SubClassOf(obo:CL_1000315 obo:CL_1000313)
SubClassOf(obo:CL_1000315 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009971))
@@ -31696,7 +32260,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000317 "FMA:263046")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000317 "goblet cell of epithelium of intestinal villus")
AnnotationAssertion(rdfs:label obo:CL_1000317 "intestinal villus goblet cell")
-EquivalentClasses(obo:CL_1000317 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001213)))
+EquivalentClasses(obo:CL_1000317 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0013636)))
SubClassOf(obo:CL_1000317 obo:CL_1000495)
SubClassOf(obo:CL_1000317 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0013636))
@@ -31717,14 +32281,19 @@ AnnotationAssertion(owl:deprecated obo:CL_1000319 "true"^^xsd:boolean)
# Class: obo:CL_1000320 (large intestine goblet cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000320 "A goblet cell that is part of the epithelium of large intestine.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/mi.2015.32") Annotation(oboInOwl:hasDbXref "DOI:10.1042/BSR20201471") Annotation(oboInOwl:hasDbXref "DOI:10.1111/imr.12182") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-021115-105447") Annotation(oboInOwl:hasDbXref "DOI:full/10.1111/febs.15731") terms:description obo:CL_1000320 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+The large intestine goblet cell is a highly specialized type of mucosal epithelial cell that is located within the epithelial lining of the large intestine. The key function of goblet cells is the production and secretion of a protective layer of mucus which is essential for maintaining gut homeostasis. Goblet cells have a characteristic 'goblet-like' shape, which adapts them for this specific function: organelles such as the nucleus, mitochondria, ER, and Golgi apparatus are located in the basal portion of the cell; while the vesicles with mucins (required for mucus production) are located apically, close to the apical membrane where their exocytosis takes place.
+The goblet cells of the large intestine produce a thick layer of mucus that coats the intestinal lumen. This mucus provides a barrier that prevents the direct contact of intestinal cells with bacteria and other potentially toxic substances present in the digestive tract. It also lubricates the intestine to facilitate the smooth passage of digested food material. It is worth noting that the mucus system differs between the small and large intestine: although in both the mucus is built around MUC2 mucin polymers produced by goblet cells, it is becoming clear that there are several types of goblet cells that function in different ways.
+From an immunological perspective, large intestine goblet cells participate in promoting a balanced gut immune response. They contribute to the process known as immune tolerance, where they prevent the body's immune system from overreacting to the trillions of bacteria present in the gut. These cells achieve this by secreting molecules that help maintain a calm environment, limiting inflammatory reactions unless absolutely necessary. Any dysfunction or decrease in the number of goblet cells can result in a compromised intestinal barrier leading to various health issues, including inflammatory bowel disease.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000320 "FMA:263054")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000320 "https://cellxgene.cziscience.com/cellguide/CL_1000320")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000320 "goblet cell of epithelium of large intestine")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000320 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000320 "large intestine goblet cell")
-EquivalentClasses(obo:CL_1000320 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000059)))
+EquivalentClasses(obo:CL_1000320 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001278)))
SubClassOf(obo:CL_1000320 obo:CL_0002253)
SubClassOf(obo:CL_1000320 obo:CL_0019031)
-SubClassOf(obo:CL_1000320 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001278))
# Class: obo:CL_1000321 (large intestine crypt goblet cell)
@@ -31733,9 +32302,10 @@ AnnotationAssertion(obo:RO_0002175 obo:CL_1000321 obo:NCBITaxon_9606)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000321 "FMA:263056")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000321 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_1000321 "large intestine crypt goblet cell")
-EquivalentClasses(obo:CL_1000321 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 ObjectIntersectionOf(obo:UBERON_0001983 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000059)))))
+EquivalentClasses(obo:CL_1000321 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0022281)))
+SubClassOf(obo:CL_1000321 obo:CL_0002658)
SubClassOf(obo:CL_1000321 obo:CL_1000320)
-SubClassOf(obo:CL_1000321 ObjectSomeValuesFrom(obo:BFO_0000050 ObjectIntersectionOf(obo:UBERON_0000483 ObjectSomeValuesFrom(obo:BFO_0000050 ObjectIntersectionOf(obo:UBERON_0001983 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000059))))))
+SubClassOf(obo:CL_1000321 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0022281))
# Class: obo:CL_1000322 (pancreatic goblet cell)
@@ -31748,7 +32318,7 @@ AnnotationAssertion(rdfs:label obo:CL_1000322 "pancreatic goblet cell")
EquivalentClasses(obo:CL_1000322 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001264)))
SubClassOf(obo:CL_1000322 obo:CL_0000069)
SubClassOf(obo:CL_1000322 obo:CL_0000160)
-SubClassOf(obo:CL_1000322 obo:CL_1001433)
+SubClassOf(obo:CL_1000322 obo:CL_1001599)
SubClassOf(obo:CL_1000322 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009970))
# Class: obo:CL_1000323 (pyloric gastric gland goblet cell)
@@ -31759,8 +32329,9 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000323 "goblet cell of epit
AnnotationAssertion(rdfs:label obo:CL_1000323 "pyloric gastric gland goblet cell")
EquivalentClasses(obo:CL_1000323 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008861)))
SubClassOf(obo:CL_1000323 obo:CL_0000152)
+SubClassOf(obo:CL_1000323 obo:CL_0002659)
SubClassOf(obo:CL_1000323 obo:CL_1000313)
-SubClassOf(obo:CL_1000323 ObjectSomeValuesFrom(obo:BFO_0000050 ObjectIntersectionOf(obo:UBERON_0000483 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008861))))
+SubClassOf(obo:CL_1000323 ObjectSomeValuesFrom(obo:BFO_0000050 ObjectIntersectionOf(obo:UBERON_0001276 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008861))))
# Class: obo:CL_1000324 (duodenal goblet cell)
@@ -31770,9 +32341,9 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000324 "FMA:263063")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000324 "goblet cell of epithelium proper of duodenum")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000324 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_1000324 "duodenal goblet cell")
-EquivalentClasses(obo:CL_1000324 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002114)))
+EquivalentClasses(obo:CL_1000324 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008346)))
SubClassOf(obo:CL_1000324 obo:CL_1000317)
-SubClassOf(obo:CL_1000324 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008346))
+SubClassOf(obo:CL_1000324 obo:CL_1001589)
# Class: obo:CL_1000325 (jejunal goblet cell)
@@ -31782,20 +32353,26 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000325 "FMA:263065")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000325 "goblet cell of epithelium proper of jejunum")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000325 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_1000325 "jejunal goblet cell")
-EquivalentClasses(obo:CL_1000325 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002115)))
+EquivalentClasses(obo:CL_1000325 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000400)))
SubClassOf(obo:CL_1000325 obo:CL_1000317)
-SubClassOf(obo:CL_1000325 ObjectSomeValuesFrom(obo:BFO_0000050 ObjectIntersectionOf(obo:UBERON_0000483 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002115))))
+SubClassOf(obo:CL_1000325 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000400))
# Class: obo:CL_1000326 (ileal goblet cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000326 "A goblet cell that is part of the epithelium proper of ileum.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s11894-010-0131-2") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nature10863") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-022-00675-x") Annotation(oboInOwl:hasDbXref "DOI:10.1111/imr.12182") terms:description obo:CL_1000326 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+The ileal goblet cell is a subset of intestinal goblet cells that are a key component of the epithelium of the ileum, a portion of the small intestine. Goblet cells are named and characterized by their distinctive 'goblet' shape with a narrow base tapering to a broad apical surface; located between the lumen of the intestine and the internal environment of the body, they serve an integral role in maintaining gut homeostasis.
+Like all intestinal goblet cells, the primary function of ileal goblet cells is the production and secretion of mucins, large, heavily glycosylated proteins that combine to form mucus. This mucus lining serves as a protective barrier, shielding the underlying tissue from the potentially damaging effects of digestive enzymes, acids, or pathogenic microbes present in the gut lumen. Their strategic location in the ileal segment of the intestinal tract aids in efficient nutrient absorption while also maintaining an impregnable barrier against potential pathogens, ensuring an intricate balance.
+Goblet cells of the ileum also play a significant role in immune modulation. They are thought to promote oral tolerance (the immune unresponsiveness to orally ingested antigens such as food) by delivering luminal antigens to underlying dendritic cells, thereby driving immune education and tolerogenic responses. They also secrete bioactive molecules, such as the trefoil factor peptide TFF3, which aids in repairing damaged epithelium. By performing these crucial functions, ileal goblet cells not only aid in maintaining intestinal health, but also contribute significantly to the overall well-being of the organism.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000326 "FMA:263067")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000326 "https://cellxgene.cziscience.com/cellguide/CL_1000326")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000326 "goblet cell of epithelium proper of ileum")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000326 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000326 "ileal goblet cell")
-EquivalentClasses(obo:CL_1000326 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002116)))
+EquivalentClasses(obo:CL_1000326 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008345)))
SubClassOf(obo:CL_1000326 obo:CL_1000317)
-SubClassOf(obo:CL_1000326 ObjectSomeValuesFrom(obo:BFO_0000050 ObjectIntersectionOf(obo:UBERON_0000483 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002116))))
+SubClassOf(obo:CL_1000326 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008345))
# Class: obo:CL_1000327 (appendix goblet cell)
@@ -31803,10 +32380,9 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000327 "FMA:263069")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000327 "goblet cell of epithelium proper of appendix")
AnnotationAssertion(rdfs:label obo:CL_1000327 "appendix goblet cell")
-EquivalentClasses(obo:CL_1000327 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001154)))
+EquivalentClasses(obo:CL_1000327 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009697)))
SubClassOf(obo:CL_1000327 obo:CL_1000320)
SubClassOf(obo:CL_1000327 obo:CL_1000405)
-SubClassOf(obo:CL_1000327 ObjectSomeValuesFrom(obo:BFO_0000050 ObjectIntersectionOf(obo:UBERON_0000483 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001154))))
# Class: obo:CL_1000328 (obsolete goblet cell of epithelium proper of large intestine)
@@ -31819,7 +32395,13 @@ AnnotationAssertion(owl:deprecated obo:CL_1000328 "true"^^xsd:boolean)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000329 "A goblet cell that is part of the epithelium of trachea.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000329 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/S1357-2725(02)00083-3") Annotation(oboInOwl:hasDbXref "DOI:10.1164/ajrccm.154.6.8970383") Annotation(oboInOwl:hasDbXref "DOI:10.1165/ajrcmb.25.5.f218") Annotation(oboInOwl:hasDbXref "DOI:10.2147/COPD.S38938") Annotation(oboInOwl:hasDbXref "DOI:10.3109/01902148.2013.791733") terms:description obo:CL_1000329 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Tracheal goblet cells are specialized cells found in the lining of the trachea. They are a key component of the tracheobronchial epithelium, a critical region responsible for maintaining open airways and preventing the ingress of harmful particles or irritants. Goblet cells are filled with membrane-bound secretory granules, which are responsible for their distinctive, goblet-like shape.
+Goblet cells specialize in the production and secretion of mucus, a slimy substance composed primarily of glycoproteins (mucins) and water. This sticky mucus serves to trap foreign particles and pollutants, such as dust, bacteria, and viruses that an organism breathes in. After trapping these particles, the cilia on neighboring ciliated epithelial cells beat synchronously, forming a coordinated escalator to push mucus upwards toward the pharynx, where it's either swallowed or expectorated. This system, known as the mucociliary clearance or escalator, forms a crucial barrier in the lungs against respiratory pathogens and external insults.
+Changes in the number or function of tracheal goblet cells can engender health complications. For example, goblet cell hyperplasia, or excessive growth of goblet cells, is a common feature of chronic inflammatory lung diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD). This condition results in mucus hypersecretion, airway blockage, and increased risk of respiratory tract infections.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000329 "FMA:263075")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000329 "https://cellxgene.cziscience.com/cellguide/CL_1000329")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:263075") oboInOwl:hasExactSynonym obo:CL_1000329 "goblet cell of epithelium of trachea")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000329 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000329 core:human_reference_atlas)
@@ -31833,7 +32415,13 @@ SubClassOf(obo:CL_1000329 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000190
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000330 "A serous secreting cell that is part of the epithelium of trachea.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000330 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/dvdy.24250") Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-012330215-1/50029-6") Annotation(oboInOwl:hasDbXref "DOI:10.1016/S0034-5687(01)00214-") Annotation(oboInOwl:hasDbXref "DOI:10.1074/jbc.M208826200") terms:description obo:CL_1000330 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Serous cells are specialized epithelial cells and can be found lining the trachea and brochus. They are among the major components of the respiratory epithelium.
+These cells are known for their production and release of serous secretions, which form a key component of airway mucus. These secretions primarily comprise of water, proteins, and enzymes, such as lysozyme and peroxidases. Their main purposes are to provide hydration and lubrication to the airway tissue and to act as a defense mechanism against pathogens. While the lysozyme and peroxidases contribute to the destruction of bacteria, the water in the secretions helps to liquefy the mucus, facilitating the effective functioning of the ciliated cells that propel the mucus up the trachea.
+The coordinated action between serous cells and other cell types in the tracheal epithelium proves essential for maintaining a healthy respiratory tract. Dysfunction or damage of these cells can lead to various respiratory tract disorders, such as cystic fibrosis and asthma.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000330 "FMA:263078")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000330 "https://cellxgene.cziscience.com/cellguide/CL_1000330")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000330 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000330 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_1000330 "serous cell of epithelium of trachea")
@@ -31845,7 +32433,12 @@ SubClassOf(obo:CL_1000330 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000190
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000331 "A serous secreting cell that is part of the epithelium of bronchus.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000331 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00039.2014") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK534789/") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/neuroscience/secretory-cell") terms:description obo:CL_1000331 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Serous cells of the epithelium of the bronchus, also termed bronchial serous cells, are predominantly found within the seromucous glands located in the bronchial submucosa. Serous cells can also be found in the trachea and are characterized by small, sparse, electron-dense granules.
+Serous cells are specialized cells responsible for the production and secretion of serous fluid. Serous fluid, mainly composed of water, proteins, and various types of salts, provides many benefits: it helps moisturize the airways, keep the bronchial tube walls moist, and safeguard the bronchial tubes against various foreign particles and infectious agents such as bacteria and viruses. Moreover, the fluid released by these cells assists in the lubrication and reduced friction in the bronchi, allowing for smoother airflow.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000331 "FMA:263080")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000331 "https://cellxgene.cziscience.com/cellguide/CL_1000331")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000331 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000331 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_1000331 "serous cell of epithelium of bronchus")
@@ -31876,7 +32469,7 @@ SubClassOf(obo:CL_1000333 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_860000
# Class: obo:CL_1000334 (enterocyte of epithelium of small intestine)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000334 "An enterocyte that is part of the epithelium of small intestine.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrgastro.2013.35") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri3738") Annotation(oboInOwl:hasDbXref "DOI:10.1084/jem.20191130") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2021.699152/full") terms:description obo:CL_1000334 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrgastro.2013.35") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri3738") Annotation(oboInOwl:hasDbXref "DOI:10.1084/jem.20191130") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2021.699152/full") terms:description obo:CL_1000334 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Enterocytes of the epithelium of the small intestine are specialized cells that reside in the lining of the small intestine, and are primarily responsible for the essential process of nutrient absorption. These cells are columnar epithelial cells with an apical surface lined with microvilli, a feature referred to as the 'brush border', to maximize the surface area available for absorption.
Enterocytes play a critical role in both the digestion and absorption of nutrients from food. Their extensive brush border contains enzymes that further assist in nutrient breakdown and transport proteins that transfer nutrients, such as glucose, amino acids, lipids, and vitamins, across the cell membrane.
@@ -31885,6 +32478,10 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000334 "FMA:263086")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000334 "https://cellxgene.cziscience.com/cellguide/CL_1000334")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000334 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000334 "enterocyte of epithelium of small intestine")
+AnnotationAssertion(Annotation(dc:license "http://creativecommons.org/licenses/by/4.0/") Annotation(rdfs:comment "Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).
+
+ISC: Intestinal Stem Cell
+TA: Transit Amplifying Cells") foaf:depiction obo:CL_1000334 )
EquivalentClasses(obo:CL_1000334 ObjectIntersectionOf(obo:CL_0000584 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001902)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1000334 obo:CL_0000584)
SubClassOf(obo:CL_1000334 obo:CL_0002254)
@@ -31911,8 +32508,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000337 "FMA:263092")
AnnotationAssertion(rdfs:label obo:CL_1000337 "enterocyte of epithelium of duodenal gland")
EquivalentClasses(obo:CL_1000337 ObjectIntersectionOf(obo:CL_0000584 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001212)))
-SubClassOf(obo:CL_1000337 obo:CL_0000584)
-SubClassOf(obo:CL_1000337 obo:CL_0002254)
+SubClassOf(obo:CL_1000337 obo:CL_1000334)
SubClassOf(obo:CL_1000337 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001212))
# Class: obo:CL_1000338 (enterocyte of epithelium of crypt of Lieberkuhn of small intestine)
@@ -31948,7 +32544,7 @@ SubClassOf(obo:CL_1000341 obo:CL_1000339)
# Class: obo:CL_1000342 (enterocyte of epithelium proper of ileum)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000342 "An enterocyte that is part of the epithelium proper of ileum.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri3738") Annotation(oboInOwl:hasDbXref "DOI:10.1084/jem.20191130") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1365-2249.2011.04523.x") terms:description obo:CL_1000342 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri3738") Annotation(oboInOwl:hasDbXref "DOI:10.1084/jem.20191130") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1365-2249.2011.04523.x") terms:description obo:CL_1000342 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Enterocytes of the epithelium proper of the ileum, commonly known as ileal enterocytes, are specialized epithelial cells found lining the inner surface of the ileum, the final section of the small intestine in the human body. They play a pivotal role in nutrient absorption, digestive metabolic functions, and the maintenance of the host’s immune response.
Like enterocytes in other parts of the intestine, ileal enterocytes exhibit distinct characteristics specific to their function and role. They have microvilli on their apical surfaces to increase absorption and are important in the absorption of vitamins and the reabsorption of bile salts. These cells also produce enzymes that metabolize lipids and xenobiotics.")
@@ -31961,9 +32557,19 @@ SubClassOf(obo:CL_1000342 obo:CL_1000339)
# Class: obo:CL_1000343 (paneth cell of epithelium of small intestine)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000343 "A paneth cell that is part of the epithelium of small intestine.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00018-002-8412-z") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nature09637") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrmicro2546") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-030212-183744") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2020.00587") terms:description obo:CL_1000343 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Paneth cells of the epithelium of the small intestine, often referred to simply as Paneth cells, are a type of specialized secretory cell that forms an integral part of the intestinal crypts of Lieberkühn – gland-like invaginations lining the small intestine. Named after the Austrian physician Josef Paneth, who first identified them in the late 19th century, these cells are significant because of their substantial involvement in the mucosal immune system and intestinal stem cell maintenance.
+Functionally, Paneth cells play a key role in maintaining gut homeostasis and in the first line of antimicrobial defense, mainly through the secretion of a range of antimicrobial peptides and proteins. These include lysozymes, cryptdins, or alpha-defensins, which have potent activity against various gut pathogens including bacteria, fungi, and parasites. Furthermore, Paneth cells of the small intestine are also known to release secretory phospholipase A2, an enzyme active against gram-positive bacteria. Additionally, they secrete several growth factors like EGF, TGF-alpha, and Wnt3, which are crucial for stem cell support and the overall maintenance of intestinal mucosal integrity.
+The unique location of Paneth cells at the base of the crypts positions them in very close proximity to intestinal stem cells. This not only facilitates their role in stem cell maintenance but also involves them in epithelial regeneration and repair following injury. Dysfunctional Paneth cells have been associated with several gut disorders, like Crohn’s disease and necrotizing enterocolitis.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000343 "FMA:263104")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000343 "https://cellxgene.cziscience.com/cellguide/CL_1000343")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000343 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000343 "paneth cell of epithelium of small intestine")
+AnnotationAssertion(Annotation(dc:license "http://creativecommons.org/licenses/by/4.0/") Annotation(rdfs:comment "Figure depicts a cross section of intestinal villi in the small intestine , including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).
+
+ISC: Intestinal Stem Cell
+TA: Transit Amplifying Cells") foaf:depiction obo:CL_1000343 )
EquivalentClasses(obo:CL_1000343 ObjectIntersectionOf(obo:CL_0000510 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001902)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1000343 obo:CL_0000510)
SubClassOf(obo:CL_1000343 obo:CL_1001598)
@@ -31995,28 +32601,35 @@ SubClassOf(obo:CL_1000346 obo:CL_0002071)
# Class: obo:CL_1000347 (colonocyte)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000347 "A columnar cell of the colon that is part of the colonic epithelium.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s11894-010-0130-3") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrgastro.2013.35") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri3738") Annotation(oboInOwl:hasDbXref "DOI:10.1084/jem.20191130") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2019.00277") terms:description obo:CL_1000347 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:16870803") Annotation(oboInOwl:hasDbXref "PMID:23821742") Annotation(oboInOwl:hasDbXref "PMID:34497389") obo:IAO_0000115 obo:CL_1000347 "An enterocyte (absorptive epithelial cell) of the colonic epithelium, characterized by a columnar shape. This cell is responsible for the absorption, transport, and metabolization of short-chain fatty acids (SCFAs) produced by gut bacteria, as well as the transport and absorption of water and electrolytes.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s11894-010-0130-3") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrgastro.2013.35") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nri3738") Annotation(oboInOwl:hasDbXref "DOI:10.1084/jem.20191130") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2019.00277") terms:description obo:CL_1000347 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Enterocytes of the colon are specialized epithelial cells located in the lining of the colon, the largest part of the large intestine. These cells play a critical role in absorbing water, electrolytes, and certain vitamins from the food material passed on from the small intestine. With a unique structure of finger-like protrusions referred to as microvilli, the enterocytes increase their surface area for effective absorption. The colon is the last part of the digestive system, and as such, it is responsible for compacting undigested food materials and forming fecal matter. Enterocytes of the colon facilitate this process effectively through absorption of water.
Enterocytes are known for their high regeneration potential, replenishing every 4-5 days, enabling the healthy functioning of the colon. They originate from stem cells located in the crypt of the colon and differentiate into mature enterocytes as they migrate upwards towards the luminal surface. This constant turnover aids in maintaining the intestinal barrier, preventing the entry of detrimental substances into the systemic circulation. Their tight junctions with other epithelial cells provide a robust barrier against invasive pathogens.
Enterocytes of the colon are involved in the communication with the gut microbiota. These cells harbor enzymes necessary for the metabolism of short-chain fatty acids, which are the byproducts of the fermentation process by gut bacteria. Short-chain fatty acids serve as a major energy source for colonocytes and are important for maintaining colonic health. The dysfunction of enterocytes, therefore, could lead to disorders such as inflammatory bowel disease or colorectal cancer.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000347 "FMA:263114")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000347 "https://cellxgene.cziscience.com/cellguide/CL_1000347")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34497389") oboInOwl:hasExactSynonym obo:CL_1000347 "colonocyte")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000347 "enterocyte of colon")
AnnotationAssertion(oboInOwl:hasNarrowSynonym obo:CL_1000347 "vacuolar absorptive cell of epithelium of colon")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000347 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000347 "colonocyte")
EquivalentClasses(obo:CL_1000347 ObjectIntersectionOf(obo:CL_0002071 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000397)))
-SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1000347 obo:CL_0002071)
+SubClassOf(obo:CL_1000347 obo:CL_0002071)
SubClassOf(obo:CL_1000347 obo:CL_0011108)
+SubClassOf(obo:CL_1000347 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0019626))
+SubClassOf(obo:CL_1000347 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0035377))
# Class: obo:CL_1000348 (basal cell of epithelium of trachea)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000348 "A basal cell that is part of the epithelium of trachea.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000348 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1164/rccm.201408-1492PP") Annotation(oboInOwl:hasDbXref "DOI:10.1165/rcmb.2021-0150ED") Annotation(oboInOwl:hasDbXref "DOI:10.1242/dmm.006031") Annotation(oboInOwl:hasDbXref "DOI:10.3389/falgy.2021.787128") terms:description obo:CL_1000348 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Basal cells of epithelium of trachea are a vital cell population within the respiratory tract's lining, specifically in the trachea's epithelium. These cells are located at the base of the columnar epithelial cell layer and can be identified by their characteristic cuboidal shape, a large nucleus and few organelles, as well as scattered microvilli. The basal cells are not in direct contact with the lumen, which is covered by a layer of ciliated and non-ciliated columnar cells. Instead, the basal cells are connected to, and line, a thin basement membrane.
+The primary function of basal cells involves stem cell activity and epithelial tissue maintenance. Basal cells in the trachea play a crucial role in the regeneration and repair of the tracheal epithelium during damage or injury, acting as progenitor cells for ciliated and secretory cells. They serve as a reserve pool of cells, ready to proliferate and differentiate as needed for homeostatic tissue maintenance or in repair processes when the epithelium has been compromised, whether by injury or disease.
+These cells are also implicated in numerous disease pathways. Conditions like chronic obstructive pulmonary disease and lung cancer exhibit unusual behavior and quantities of tracheal basal cells, making these cells a focal point in respiratory disease research. In summary, basal cells in the tracheal epithelium have a multifaceted role in maintaining, repairing, and influencing tracheal health, playing a crucial role in the stability of the respiratory system.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000348 "FMA:263118")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000348 "https://cellxgene.cziscience.com/cellguide/CL_1000348")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000348 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000348 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_1000348 "basal cell of epithelium of trachea")
@@ -32028,7 +32641,13 @@ SubClassOf(obo:CL_1000348 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000190
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000349 "A basal cell found in the bronchus epithelium.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000349 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/ar.1092380310") Annotation(oboInOwl:hasDbXref "DOI:10.1038/labinvest.2015.114") Annotation(oboInOwl:hasDbXref "DOI:10.1136/thx.2004.la0104") Annotation(oboInOwl:hasDbXref "DOI:10.3389/falgy.2021.787128") terms:description obo:CL_1000349 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+The basal cells of the epithelium of the bronchus are a vital component of the cellular linings found within the bronchial tubes of the respiratory system. They are typically nonciliated, cuboidal cells that are tightly attached to the basement membrane, thereby providing structural support for the epithelial tissues.
+The function of the basal cell of the bronchial epithelium is multifaceted, underscoring the importance of these cells for respiratory health. One of their primary roles involves regeneration and cellular turnover. They serve as local stem cells, being able to proliferate and differentiate into other cell types such as ciliated and secretory epithelial cells. This regenerative function of basal cells is required for maintaining the integrity of the bronchial epithelium and is especially critical after injury or during disease states when there is an increased need for new cells to repair damaged tissue or replace lost cells.
+In addition to these regenerative duties, basal cells of the bronchial epithelium play a crucial role in providing a defensive barrier against inhaled substances. They participate in the coordinated immune response directed against airborne pathogens, foreign particles, and toxins that enter the respiratory tract. Basal cells can respond to inflammation or irritation by altering their activities, which include proliferating, differentiating, or producing bioactive substances. Throughout all these responses, the basal cells help to maintain the homeostasis of the bronchial tubes, allowing for the efficient transport of air to and from the lungs.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000349 "FMA:263120")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000349 "https://cellxgene.cziscience.com/cellguide/CL_1000349")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000349 "basal cell of bronchus")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000349 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_1000349 "basal cell of epithelium of bronchus")
@@ -32073,7 +32692,15 @@ SubClassOf(obo:CL_1000352 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_860000
# Class: obo:CL_1000353 (microfold cell of epithelium of small intestine)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000353 "A M cell that is part of the epithelium of small intestine.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/mi.2013.30") Annotation(oboInOwl:hasDbXref "DOI:10.1093/jb/mvv121") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1574-695X.2007.00359.x") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2019.01499") terms:description obo:CL_1000353 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Microfold cells, also widely known as M cells, are a distinct type of epithelial cell found in the gut, including the small intestine, specifically within the Peyer’s patches, a component of the gut-associated lymphoid tissue (GALT). M cells play a crucial role in the immune response within the intestine environment.
+These cells are characterized by microfolds (short microvilli, which give them their name), a reduced, thin glycocalyx, and a deeply invaginated basolateral membrane next to immune cells such as B cells, T cells, and macrophages, and DCs.
+These features allow the M cells to form the first point of contact between the gut lumen and the intestinal immune system. They are well-regulated gateways that capture and transport antigens, such as bacteria, viruses, and other foreign substances found in the lumen, to the underlying cells of the immune system. This specialized transport mechanism, called ‘transcytosis’, involves engulfment of these antigens from the apical side, transport across their cytoplasm, and release on the basolateral side of the cells, where immune responses can be initiated.
+Furthermore, M cells have complex interactions with members of the gut microbiota and other immune cells, making them essential for maintaining gut homeostasis. This cross-talk shapes the diversity and makeup of the gut microbiota, subsequently having a substantial impact on the host's health. In certain situations, pathogenic organisms can exploit the transcytosis mechanism to infiltrate the host's system, causing various infectious diseases.
+The overarching significance of M cells in the small intestine lies in their role of surveillance and protection against a wide range of potentially harmful pathogens, while also facilitating beneficial interactions with commensal microbes.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000353 "FMA:263128")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000353 "https://cellxgene.cziscience.com/cellguide/CL_1000353")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000353 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000353 "microfold cell of epithelium of small intestine")
EquivalentClasses(obo:CL_1000353 ObjectIntersectionOf(obo:CL_0000682 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002108)))
@@ -32132,7 +32759,6 @@ AnnotationAssertion(rdfs:label obo:CL_1000359 "microfold cell of epithelium prop
EquivalentClasses(obo:CL_1000359 ObjectIntersectionOf(obo:CL_0000682 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001154)))
SubClassOf(obo:CL_1000359 obo:CL_1000360)
SubClassOf(obo:CL_1000359 obo:CL_1000405)
-SubClassOf(obo:CL_1000359 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009697))
# Class: obo:CL_1000360 (microfold cell of epithelium proper of large intestine)
@@ -32437,8 +33063,14 @@ SubClassOf(obo:CL_1000397 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000996
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:3926620") obo:IAO_0000115 obo:CL_1000398 "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000398 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.jhep.2016.07.009") Annotation(oboInOwl:hasDbXref "DOI:10.1038/cmi.2016.5") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-018-0020-y") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-020-00411-3") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/immunology-and-microbiology/disse-space") terms:description obo:CL_1000398 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Endothelial cells of hepatic sinusoids, also known as hepatic or liver sinusoidal endothelial cells (HSEC or LSEC), are unique, specialized type of endothelial cells located in the liver. They are the building units of the hepatic sinusoid, which functions as a specialized capillary system that facilitates the exchange of various substances between the blood and hepatocytes. This finely tuned environment, facilitated by HSEC, is primordial for the liver's multiple physiologic functions that include nutrient metabolism, toxin inactivation, and immunomodulation.
+The HSEC have a distinctive morphology that sets them apart from the typical endothelial cells found in other organs. These cells are exceptionally thin to allow for efficient transfer of molecules and characterized by fenestrations, which are non-diaphragmatic, sieve-like openings that provide an open filtration pathway from the sinusoidal lumen to the space of Disse, where hepatocytes are exposed. The fenestration is a crucial feature that allows lipoproteins, nutrients, and other plasma components easy access to hepatocytes for essential liver functions, including clearance of waste products and metabolic regulation.
+HSECs further play a vital role in immune functionality in the liver. They act as a sentinel, determining the nature of the immune response to encountered particulates. They possess a capacity for antigen presentation and express a series of immune-related surface molecules, which helps in immunosurveillance and immunoregulation. The HSEC also aid in the removal and destruction of virus-infected cells, harmful microorganisms, and circulatory waste products to safeguard liver health and general systemic cleanliness.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000398 "BTO:000125")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000398 "FMA:62911")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000398 "https://cellxgene.cziscience.com/cellguide/CL_1000398")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30348985") oboInOwl:hasExactSynonym obo:CL_1000398 "LSEC")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:62911") oboInOwl:hasExactSynonym obo:CL_1000398 "endotheliocyte of hepatic sinusoid")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30348985") oboInOwl:hasExactSynonym obo:CL_1000398 "liver sinusoidal endothelial cell")
@@ -32493,9 +33125,9 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000405 "FMA:63602")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:63602") oboInOwl:hasExactSynonym obo:CL_1000405 "columnar epitheliocyte of appendix")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:63602") oboInOwl:hasExactSynonym obo:CL_1000405 "epithelial cell of vermiform appendix")
AnnotationAssertion(rdfs:label obo:CL_1000405 "epithelial cell of appendix")
-EquivalentClasses(obo:CL_1000405 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001154)))
+EquivalentClasses(obo:CL_1000405 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009697)))
SubClassOf(obo:CL_1000405 obo:CL_0002253)
-SubClassOf(obo:CL_1000405 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001154))
+SubClassOf(obo:CL_1000405 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009697))
# Class: obo:CL_1000406 (obo:CL_1000406)
@@ -32524,6 +33156,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:pr") oboInOwl:hasExactSyn
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:pr") oboInOwl:hasExactSynonym obo:CL_1000409 "sinoatrial node cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000409 "sinoatrial node myocyte")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:67102") oboInOwl:hasExactSynonym obo:CL_1000409 "sinuatrial node myocyte")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_1000409 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000409 "myocyte of sinoatrial node")
EquivalentClasses(obo:CL_1000409 ObjectIntersectionOf(obo:CL_0000187 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002351)))
SubClassOf(obo:CL_1000409 obo:CL_0002072)
@@ -32571,7 +33204,7 @@ SubClassOf(obo:CL_1000412 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000198
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000413 "A blood vessel endothelial cell that is part of an arterial endothelium.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000413 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00441-008-0706-5") Annotation(oboInOwl:hasDbXref "DOI:10.1007/s10456-021-09785-7") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.ccm.2021.08.005") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.jvs.2004.03.043") Annotation(oboInOwl:hasDbXref "DOI:10.1177/153857440303700107") terms:description obo:CL_1000413 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00441-008-0706-5") Annotation(oboInOwl:hasDbXref "DOI:10.1007/s10456-021-09785-7") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.ccm.2021.08.005") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.jvs.2004.03.043") Annotation(oboInOwl:hasDbXref "DOI:10.1177/153857440303700107") terms:description obo:CL_1000413 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Endothelial cells of the artery, also referred to as arterial endothelial cells, form an integral part of the arterial system. They form a single layer, known as the endothelium, lining the interior surface of arteries, and are able to respond to the high-pressure and flow conditions present in arteries. The primary role of these cells is to provide a barrier between the vessel wall and the blood, exhibiting selective permeability to regulate the movement of liquids, gases, and blood-borne substances across the vascular wall.
Arterial endothelial cells significantly contribute to maintaining vascular homeostasis. They are at the forefront of sensations and responses to mechanical stimuli, like shear stress and blood pressure changes. An additional key function pertains to the production of nitric oxide, which helps to regulate vascular tone and blood pressure, prevents platelet aggregation, limits leukocyte adhesion to the endothelium, and inhibits smooth muscle cell proliferation. These varied but connected functions help to preclude the development of atherosclerosis, ensuring normal circulation and arterial health.
@@ -32788,7 +33421,7 @@ SubClassOf(obo:CL_1000435 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000185
# Class: obo:CL_1000436 (epithelial cell of lacrimal sac)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000436 "An epithelial cell that is part of the lacrimal sac.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s004290050160") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1442-9071.2012.02818.x") Annotation(oboInOwl:hasDbXref "DOI:10.1167/tvst.8.4.32") Annotation(oboInOwl:hasDbXref "DOI:10.2147/OPTH.S26048") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2022.918619") terms:description obo:CL_1000436 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s004290050160") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1442-9071.2012.02818.x") Annotation(oboInOwl:hasDbXref "DOI:10.1167/tvst.8.4.32") Annotation(oboInOwl:hasDbXref "DOI:10.2147/OPTH.S26048") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2022.918619") terms:description obo:CL_1000436 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Epithelial cells of the lacrimal sac play a significant role in the physiology of tear drainage, acting as an integral part of the lacrimal drainage system. The lacrimal sac is part of the nasolacrimal duct system, a conduit which connects the eye to the nasal cavity, and is lined by multilayered, non-keratinizing, squamous epithelial cells.
The epithelial cells of the lacrimal sac are specialized for the purpose of maintaining a moist environment and protecting the surface of the eye. They form a barrier that traps and removes potential contaminants from the tear film during the drainage process. These cells also actively contribute to tear turnover by expediting the drainage of excess tears. Dysfunctional epithelial cells of the lacrimal sac can lead to dacryocystitis, a condition characterized by inflammation of the lacrimal sac.
@@ -32849,7 +33482,13 @@ SubClassOf(obo:CL_1000442 ObjectSomeValuesFrom(obo:BFO_0000050 ObjectIntersectio
# Class: obo:CL_1000443 (ciliary muscle cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000443 "A smooth muscle cell that is part of the ciliary body.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/S1350-9462(98)00011-1") Annotation(oboInOwl:hasDbXref "DOI:10.1038/srep31171") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1444-0938.2008.00260.x") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/medicine-and-dentistry/ciliary-muscle") terms:description obo:CL_1000443 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Ciliary muscle cells are specialized contractile cells that constitute the ciliary muscle, a component of the eye in vertebrates. These cells form a ring around the iris, the eye's colored part. Ciliary muscle cells fall into the category of smooth muscle cells, characterized by their lack of the striations typical of skeletal and cardiac muscle cells. Their shape is elongated and pointed at both ends, and they occur in multi-nucleated syncytia where many cells share the same cytoplasm.
+Ciliary muscle cells primarily control the eye's accommodation, adjusting the thickness and curvature of the lens to fine-tune the focus of light on the retina. When ciliary muscle cells contract, tension on the zonular fibers holding the lens in place is reduced, allowing the lens to become thicker and increase its refractive power. Conversely, when the ciliary muscle cells relax, the tension on the zonular fibers increases, causing the lens to become flatter and decrease its refractive power. This adjustment facilitates clear vision at different distances, ranging from near to far objects.
+Additionally, ciliary muscle cells play a role in draining the eye's aqueous humor, which is the clear fluid that fills the anterior chamber of the eye between the cornea and the lens. By controlling the shape of the surrounding trabecular meshwork through muscle contractions and relaxations, ciliary muscle cells indirectly regulate intraocular pressure, a factor critical for preventing ocular conditions like glaucoma.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000443 "FMA:70610")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000443 "https://cellxgene.cziscience.com/cellguide/CL_1000443")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:70610") oboInOwl:hasExactSynonym obo:CL_1000443 "smooth muscle cell of ciliary body")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000443 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000443 cl:eye_upper_slim)
@@ -32907,7 +33546,13 @@ SubClassOf(obo:CL_1000448 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000182
# Class: obo:CL_1000449 (epithelial cell of nephron)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000449 "An epithelial cell that is part of the nephron.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/978-94-011-2354-9_6") Annotation(oboInOwl:hasDbXref "DOI:10.1007/s004670050586") Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-0-323-35775-3.00011-4") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-052521-121841") Annotation(oboInOwl:hasDbXref "DOI:10.1681/ASN.2012010029") terms:description obo:CL_1000449 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Epithelial cells of the nephron form the epithelial lining of the nephron, the functional unit of the kidney that filters the blood to produce urine. Each kidney holds approximately one million nephrons, each of which is composed of several distinct parts, including the renal corpuscle, the proximal tubule, the loop of Henle, and the distal tubule. All sections are lined with highly specialized epithelial cells adapted to perform different functions within the sections of the nephron.
+The different epithelial cells of the nephron play crucial roles in the process of filtration, reabsorption, secretion, and excretion, essential tasks for the regulation of body fluid composition and volume. During filtration, the blood is forced through the walls of glomerular capillaries into the Bowman's capsule, where waste products, electrolytes, and water are separated from the blood cells and proteins. As the filtrate then passes through the nephron, epithelial cells of the tubular portion reabsorb useful substances such as glucose, amino acids, and electrolytes, along with most of the water back into the bloodstream. Waste products like urea and creatinine, as well as excess ions and water, remain in the tubule for elimination.
+In addition, epithelial cells of the nephron also play a vital part in maintaining the body's acid-base balance by actively secreting hydrogen ions into the urine while reabsorbing bicarbonate from the urine back into the blood. They are also involved in the regulation of blood pressure through the renin-angiotensin-aldosterone system and contribute to erythrocyte production by releasing the hormone erythropoietin in response to low oxygen levels in the blood. Abnormalities or damage in renal epithelial cells often result in impaired kidney function, leading to various renal diseases.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000449 "FMA:70965")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000449 "https://cellxgene.cziscience.com/cellguide/CL_1000449")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000449 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000449 "epithelial cell of nephron")
EquivalentClasses(obo:CL_1000449 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001285)))
@@ -32962,7 +33607,7 @@ SubClassOf(obo:CL_1000453 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000413
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000454 "An epithelial cell that is part of the collecting duct of renal tubule.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000454 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.ajpath.2014.01.014") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.semnephrol.2019.04.005") Annotation(oboInOwl:hasDbXref "DOI:10.2215/CJN.05760513") Annotation(oboInOwl:hasDbXref "DOI:10.2215/CJN.08880914") terms:description obo:CL_1000454 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.ajpath.2014.01.014") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.semnephrol.2019.04.005") Annotation(oboInOwl:hasDbXref "DOI:10.2215/CJN.05760513") Annotation(oboInOwl:hasDbXref "DOI:10.2215/CJN.08880914") terms:description obo:CL_1000454 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Kidney collecting duct epithelial cells are a specialized type of cells that form an integral part of the renal system. Located in the collecting duct system of the kidneys, these cells are responsible for one of the final steps in the process of urine formation, and they are instrumental in the fine tuning of the volume and composition of urine by reabsorbing water and certain solutes back into the bloodstream.
These cells express specific channels and carriers that actively and passively transport ions and water. They also have channels on their membranes, such as sodium channels and potassium channels, involved in reabsorbing or secreting these electrolytes depending upon the body's needs. The function of renal collecting duct epithelial cells can be regulated by a variety of hormones, including vasopressin (antidiuretic hormone), which can modulate the ion channels and carriers and hence indirectly influence body fluid homeostasis.
@@ -33004,8 +33649,13 @@ SubClassOf(obo:CL_1000457 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000117
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000458 "A melanocyte that is part of the skin of body.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000458 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.jinf.2015.06.006") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1751-1097.2007.00226.x") Annotation(oboInOwl:hasDbXref "DOI:10.1615/CritRevEukaryotGeneExpr.2020028454") Annotation(oboInOwl:hasDbXref "DOI:10.5114/pdia.2013.33376") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/melanocyte") terms:description obo:CL_1000458 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Melanocytes of the skin are specialized pigment cells crucial for producing and distributing melanin, the pigment determining skin, in addition to hair and eye color. Located in the basal layer of the epidermis, melanocytes serve as a natural sunscreen, protecting skin cells from harmful UV radiation. Structurally dendritic, they synthesize melanin through melanogenesis, transferring melanosomes to keratinocytes for UV shielding
+Beyond pigmentation and UV protection, melanocytes play roles in immune and inflammatory responses. They respond to environmental changes, communicate with skin cell types, and secrete cytokines and growth factors influencing skin homeostasis. Dysregulation may lead to pigment disorders like vitiligo and melasma or contribute to skin cancer, particularly malignant melanoma.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000458 "CALOHA:TS-2374")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000458 "FMA:72144")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000458 "https://cellxgene.cziscience.com/cellguide/CL_1000458")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:72144") oboInOwl:hasExactSynonym obo:CL_1000458 "skin melanocyte")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000458 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000458 core:human_reference_atlas)
@@ -33231,7 +33881,12 @@ SubClassOf(obo:CL_1000486 obo:CL_0000731)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000487 "A smooth muscle cell that is part of the prostate gland.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000487 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1101/cshperspect.a030510") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK279291") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/immunology-and-microbiology/smooth-muscle-cell") terms:description obo:CL_1000487 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Smooth muscle cells of the prostate constitute a critical component of the prostatic stroma, enveloping glandular structures to support functions like secretion and fluid expulsion. Like other smooth muscles, smooth muscle cells of the prostate lack the striations characteristic of skeletal and cardiac muscle cell.
+Functionally, they play a crucial role in reproductive and urinary functions. Smooth muscle cells of the prostate contribute to the transport and expulsion of prostatic secretions into the urethra and respond dynamically to signaling molecules such as hormones and neurotransmitters. For instance, under sympathetic nervous stimulation, they contract and apply pressure on the gland's ducts, facilitating the secretion process.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000487 "FMA:84583")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000487 "https://cellxgene.cziscience.com/cellguide/CL_1000487")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:84583") oboInOwl:hasExactSynonym obo:CL_1000487 "smooth muscle fiber of prostate")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000487 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000487 core:human_reference_atlas)
@@ -33243,7 +33898,7 @@ SubClassOf(obo:CL_1000487 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000236
# Class: obo:CL_1000488 (cholangiocyte)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:16550043") Annotation(oboInOwl:hasDbXref "PMID:18356246") obo:IAO_0000115 obo:CL_1000488 "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.jcmgh.2015.05.005") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.jhep.2012.10.011") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-019-0125-y") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajpgi.00227.2012") Annotation(oboInOwl:hasDbXref "DOI:10.5009/gnl16033") terms:description obo:CL_1000488 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.jcmgh.2015.05.005") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.jhep.2012.10.011") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41575-019-0125-y") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajpgi.00227.2012") Annotation(oboInOwl:hasDbXref "DOI:10.5009/gnl16033") terms:description obo:CL_1000488 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Cholangiocytes, also known as biliary epithelial cells, are specialized epithelial cells that line the biliary tract, which constitutes the gall bladder and bile ducts inside the liver. Crucial to the maintenance of the liver's health and function, cholangiocytes have a key role in the modification and secretion of bile, a fluid produced by hepatocytes that is essential to digestion and the absorption of fats and vitamins.
Cholangiocytes accomplish their primary function through the expression of a variety of transport proteins located on their apical and basolateral membranes, which propel bile acids and other contents of the bile into the biliary lumen. The hepatic bile, once secreted by the hepatocytes, is further modified by cholangiocytes via secretion and absorption processes. These processes help in the regulation of bile volume and composition, which is fundamental in ensuring the efficient digestion of dietary fats and fat-soluble vitamins and the excretion of cholesterol.
@@ -33286,7 +33941,7 @@ SubClassOf(obo:CL_1000490 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000235
# Class: obo:CL_1000491 (mesothelial cell of pleura)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000491 "A mesothelial cell that is part of the pleura.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.ccm.2021.08.005") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.coi.2020.04.005") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajplung.90587.2008") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2014.00284") terms:description obo:CL_1000491 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.ccm.2021.08.005") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.coi.2020.04.005") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajplung.90587.2008") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2014.00284") terms:description obo:CL_1000491 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Mesothelial cells of the pleura form a significant part of the pleural membrane, a thin, double-layered serous membrane that lines the thoracic cavity and encompasses the lungs. These specialized cells contribute to the pleura's key function of producing a lubricating serous fluid, which reduces friction between the lung's outer surface (visceral pleura) and the inner lining of the thoracic cavity (parietal pleura) during respiration.
The cellular structure of mesothelial cells, characterized by microvilli on their surface, aids in the secretion and absorption of the pleural fluid, effectively supporting the smooth expansion and contraction of the lungs. Dysregulation in mesothelial cells can lead to pathologies, including pleural effusion and malignant mesothelioma.
@@ -33314,7 +33969,7 @@ SubClassOf(obo:CL_1000492 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000240
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000493 "A mesothelial cell that is part of the visceral pleura.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000493 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/S1357-2725(03)00242-5") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00026.2003") Annotation(oboInOwl:hasDbXref "DOI:10.1371/journal.pone.0276978") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2014.00221") Annotation(oboInOwl:hasDbXref "DOI:10.3390/jdb7020007") terms:description obo:CL_1000493 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/S1357-2725(03)00242-5") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00026.2003") Annotation(oboInOwl:hasDbXref "DOI:10.1371/journal.pone.0276978") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2014.00221") Annotation(oboInOwl:hasDbXref "DOI:10.3390/jdb7020007") terms:description obo:CL_1000493 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Mesothelial cells of visceral pleura are specialized epithelial cells that line the inner layer of the pleura, the membrane that envelops the lungs. Positioned adjacent to the lung tissue, these cells form a protective barrier and contribute to the structure of the visceral pleura. They are characterized by their cuboidal to squamous epithelial shape and the presence of microvilli on their surface, a feature aiding in fluid and solute exchange between the pleura and the lungs.
The primary function of mesothelial cells of visceral pleura is to secrete a lubricating serous fluid to facilitate smooth, frictionless lung movement within the thoracic cavity during respiration. This helps in the prevention of trauma or damage stemming from the constant rubbing of the lung tissue against the chest wall, hence playing a pivotal role in maintaining respiratory function. Besides fluid secretion, these cells have an essential role in the transportation of fluids and particles across the pleura, as well as in inflammation, wound healing, and tissue repair processes within the pleura.
@@ -33351,10 +34006,9 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000495 "goblet cell of smal
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:86929") oboInOwl:hasExactSynonym obo:CL_1000495 "small intestinal goblet cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000495 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000495 "small intestine goblet cell")
-EquivalentClasses(obo:CL_1000495 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002108)))
-SubClassOf(obo:CL_1000495 obo:CL_0002254)
+EquivalentClasses(obo:CL_1000495 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001902)))
SubClassOf(obo:CL_1000495 obo:CL_0019031)
-SubClassOf(obo:CL_1000495 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001902))
+SubClassOf(obo:CL_1000495 obo:CL_1001598)
# Class: obo:CL_1000497 (kidney cell)
@@ -33626,6 +34280,7 @@ SubClassOf(obo:CL_1000693 obo:CL_1000500)
AnnotationAssertion(obo:RO_0002175 obo:CL_1000695 obo:NCBITaxon_9606)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000695 "KUPO:0001106")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_1000695 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000695 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_1000695 "kidney interstitial alternatively activated macrophage")
SubClassOf(obo:CL_1000695 obo:CL_0000890)
@@ -33648,7 +34303,14 @@ SubClassOf(obo:CL_1000697 obo:CL_1000500)
# Class: obo:CL_1000698 (kidney resident macrophage)
AnnotationAssertion(obo:IAO_0000115 obo:CL_1000698 "A tissue-resident macrophage that is part of some kidney.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/bs.ircmb.2022.01.005") Annotation(oboInOwl:hasDbXref "DOI:10.1172/jci.insight.161078") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2021.681748") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2017.00837") terms:description obo:CL_1000698 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Kidney resident macrophages are a heterogeneous population of immune cell found in the cortex and medullary regions of the kidney as well as within and surround the glomeruli. Their primary role involves maintaining homeostasis and immune surveillance in the kidney microenvironment, defending against ascending urinary infections. Beyond traditional macrophage roles such as phagocytosis and antigen presentation, kidney resident macrophages also contribute significantly to the response to kidney injury including tissue repair and angiogenesis.
+Under normal physiological conditions, kidney resident macrophages work to maintain the balance of the kidney's microenvironment by removing dead cells, pathogens and cellular debris, to limit inflammation and tissue damage. They are ‘professional’ phagocytes, clearing pathogens and debris by engulfing and digesting these harmful materials. Moreover, they are capable of presenting antigens to other immune cells, which aids in the activation of the adaptive immune response.
+Kidney resident macrophages show a high degree of plasticity: in response to environmental stimuli they change their morphology and cell surface markers. For example, in response to acute injury, some macrophages adopt a pro-inflammatory phenotype and augment tissue damage; once the injury stimulus is removed, they may change to mediate tissue repair.
+While kidney macrophages contribute to wound healing, tissue repair and regeneration by producing key growth factors and cytokines that stimulate cell proliferation, collagen production, and blood vessel formation, dysregulation in their activity can also lead to progressive inflammation and fibrosis, common features in chronic kidney disease.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000698 "KUPO:0001109")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000698 "https://cellxgene.cziscience.com/cellguide/CL_1000698")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000698 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000698 "kidney resident macrophage")
SubClassOf(obo:CL_1000698 obo:CL_0000864)
@@ -33686,12 +34348,12 @@ SubClassOf(obo:CL_1000703 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000478
# Class: obo:CL_1000706 (ureter urothelial cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1000706 "Any urothelial cell that is part of some urothelium of ureter.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:36180582") obo:IAO_0000115 obo:CL_1000706 "A urothelial cell that is part of the urothelium of ureter.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000706 "KUPO:0001117")
AnnotationAssertion(rdfs:label obo:CL_1000706 "ureter urothelial cell")
EquivalentClasses(obo:CL_1000706 ObjectIntersectionOf(obo:CL_0000731 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001254)))
-SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1000706 obo:CL_0000731)
-SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1000706 obo:CL_1000601)
+SubClassOf(obo:CL_1000706 obo:CL_0000731)
+SubClassOf(obo:CL_1000706 obo:CL_1000601)
SubClassOf(obo:CL_1000706 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001254))
# Class: obo:CL_1000708 (ureter adventitial cell)
@@ -33818,7 +34480,14 @@ SubClassOf(obo:CL_1000746 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000007
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1000768 "Any nephron tubule epithelial cell that is part of some renal connecting tubule.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000768 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/cphy.c110052") Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00418-021-02033-5") Annotation(oboInOwl:hasDbXref "DOI:10.1097/MNH.0b013e32820ac850") Annotation(oboInOwl:hasDbXref "DOI:10.1681/ASN.2019040415") Annotation(oboInOwl:hasDbXref "DOI:10.23876/j.krcp.2017.36.4.305") terms:description obo:CL_1000768 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Kidney connecting tubule epithelial cells are found in collecting duct system of the kidney, specifically in at the interconnection segment between the nephron and the collecting ducts. The epithelial cells lining the connecting tubule are crucial for the journey of filtrate before it empties into urine-collecting ducts and therefore play a critical role in maintaining the body’s fluid and electrolyte balance.
+One of the principal functions of connecting tubule epithelial cells involves the selective reabsorption and secretion of various solutes. This reabsorption process includes critical regulatory electrolytes such as sodium ions (Na+), chloride ions (Cl-), and bicarbonate ions (HCO3-), thus playing a role in the regulation of the acid-base homeostasis. Their function also involves the secretion of potassium ions (K+) into the renal tubular fluid.
+The connecting tubule epithelial cells are primarily intercalated cells, which can be categorized into two types according to their specific functions: type A intercalated cells, which secrete acid, and the type B intercalated cells, which secrete base (bicarbonate) and reabsorb chloride. By regulating the concentrations of these ions, as well as reabsorption of water, connecting tubule epithelial cells contribute substantively to maintaining the body's electrolyte levels, pH balance, and overall homeostasis.
+In addition to intercalating cells, the collecting duct system also has principal cells, which are characterized by the expression of the water channel AQP2. AQP2-expressing cells have also been identified in connecting tubules, but there is some controversy whether these represent a unique cell type as there are some morphologic differences compared with principal cells.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000768 "KUPO:0001058")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000768 "https://cellxgene.cziscience.com/cellguide/CL_1000768")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000768 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000768 cl:kidney_upper_slim)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000768 core:human_reference_atlas)
@@ -33851,7 +34520,13 @@ SubClassOf(obo:CL_1000804 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000521
# Class: obo:CL_1000838 (kidney proximal convoluted tubule epithelial cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1000838 "Any epithelial cell of proximal tubule that is part of some proximal convoluted tubule and has part some brush border.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/cphy.c110060") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-052521-121841") Annotation(oboInOwl:hasDbXref "DOI:10.1159/000092212") Annotation(oboInOwl:hasDbXref "DOI:10.1681/ASN.2019040415") terms:description obo:CL_1000838 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Kidney proximal convoluted tubule epithelial cells line the most voluminous part of the kidney's nephron, the proximal convoluted tubule, located in the cortex of the kidney. These cells are primarily involved in reabsorption and secretion processes, key functions that facilitate homeostasis within the body.
+Proximal convoluted tubule epithelial cells extensively function in the reabsorption process to a greater degree than their counterparts in the proximal straight tubule. Approximately two-thirds of filtrated sodium and water, nearly all nutrient sugars and amino acids, and a significant portion of bicarbonates pass through the proximal convoluted tubule, are effectively absorbed by the epithelial cells, and reenter the bodily circulation. By absorbing bicarbonates and secreting protons into the tubular fluid, proximal convoluted tubule epithelial cells also contribute to the pH regulation in the body .
+In addition to reabsorption, proximal convoluted tubule epithelial cells also play a critical role in the excretion of waste metabolites and xenobiotics. These cells possess a range of transporters that secrete metabolic end products and certain drugs, hence aiding in their elimination. This function underlines their importance for body detoxification.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000838 "KUPO:0001045")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000838 "https://cellxgene.cziscience.com/cellguide/CL_1000838")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000838 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000838 "kidney proximal convoluted tubule epithelial cell")
EquivalentClasses(obo:CL_1000838 ObjectIntersectionOf(obo:CL_0002306 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001287) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005903)))
@@ -33861,7 +34536,13 @@ SubClassOf(obo:CL_1000838 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000128
# Class: obo:CL_1000839 (kidney proximal straight tubule epithelial cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1000839 "Any epithelial cell of proximal tubule that is part of some proximal straight tubule.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/cphy.c110061") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrd4461") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-052521-121841") Annotation(oboInOwl:hasDbXref "DOI:10.1681/ASN.2019040415") Annotation(oboInOwl:hasDbXref "DOI:10.2215/CJN.10391012") terms:description obo:CL_1000839 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Kidney proximal straight tubule epithelial cells line the straight portion of the proximal tubule of the nephron, extending from the cortical medullary ray into the outer stripe of the outer medulla. They are characterized by a brush border of dense microvilli on their apical surface, enhancing the cell's surface area and aiding reabsorption, though reabsorption occurs more heavily in the proximal convoluted tubule preceding the straight portion of the tubule.
+The primary function of the kidney proximal straight tubule epithelial cells is to reabsorb the filtrate that the kidney produces, which includes glucose, sodium, and water. The reabsorption occurs through both passive and active transport methods. These cells exhibit enzyme-rich microvilli that also absorb small proteins and peptides. Consequently, they are involved in the regulation of plasma levels of various substances, including glucose, amino acids, and electrolytes, and maintain the body's pH homeostasis by secreting H+ ions into the urine and absorbing bicarbonate ions.
+These cells are also reported to be involved in drug metabolism. Many drugs are filtered from the blood by the kidneys and subsequently reabsorbed by the kidney proximal tubule epithelial cells back into the bloodstream. Furthermore, these cells play a significant role in the progression of kidney diseases. For example, in diabetic nephropathy and acute kidney injury, kidney proximal straight tubule epithelial cells can undergo cellular changes and result in malfunctions such as reduced reabsorption and increased excretion.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000839 "KUPO:0001046")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000839 "https://cellxgene.cziscience.com/cellguide/CL_1000839")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000839 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1000839 "kidney proximal straight tubule epithelial cell")
EquivalentClasses(obo:CL_1000839 ObjectIntersectionOf(obo:CL_0002306 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001290)))
@@ -33874,7 +34555,13 @@ SubClassOf(obo:CL_1000839 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000129
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1000849 "Any epithelial cell of distal tubule that is part of some distal convoluted tubule.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000849 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/cphy.c140002") Annotation(oboInOwl:hasDbXref "DOI:10.1007/s40620-021-01032-y") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.2000.80.1.277") Annotation(oboInOwl:hasDbXref "DOI:10.1681/ASN.2019040415") Annotation(oboInOwl:hasDbXref "DOI:10.2215/CJN.05920613") terms:description obo:CL_1000849 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Kidney distal convoluted tubule epithelial cells, often referred to simply as distal convoluted tubule (DCT) cells, constitute a significant portion of the nephron -- the functional building unit of the kidney involved in filtration and reabsorption of substances from blood. The DCT epithelial cells form lining of the distal convoluted tubule, a segment of the nephron located after the loop of Henle and before the collecting tubule. These cells are characterized by unique morphological features such as small size, low height and fewer microvilli compared to proximal convoluted tubule epithelial cells.
+These cells perform a host of vital functions contributing to the regulation of extracellular fluid volume and electrolyte balance, blood pressure and pH. While the DCT is less prominent in water and sodium reabsorption compared to the proximal tubule and the loop of Henle, it plays a crucial role in fine-tuning the process. DCT epithelial cells are responsible for the final adjustments of sodium, potassium and calcium reabsorption, thereby affecting overall fluid and electrolyte balance, blood pressure regulation and bone health. The reabsorption process is regulated by hormones including aldosterone and parathyroid hormone.
+The distal convoluted tubule (DCT) also plays a significant role in acid-base homeostasis by secreting protons (H+) into the tubular fluid and reabsorbing bicarbonate ions (HCO3-), thus regulating the pH of the blood. The ability of DCT cells to adjust urine concentration plays a part in maintaining the body’s pH balance and preventing conditions like acidosis or alkalosis. In summary, kidney distal convoluted tubule epithelial cells perform functions that are crucial to maintaining body's homeostasis.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000849 "KUPO:0001056")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000849 "https://cellxgene.cziscience.com/cellguide/CL_1000849")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000849 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000849 cl:kidney_upper_slim)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000849 core:human_reference_atlas)
@@ -33887,7 +34574,13 @@ SubClassOf(obo:CL_1000849 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000129
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1000850 "Any epithelial cell of distal tubule that is part of some macula densa.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1000850 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1073/pnas.0736323100") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-052521-121841") Annotation(oboInOwl:hasDbXref "DOI:10.1161/HYPERTENSIONAHA.115.04739") Annotation(oboInOwl:hasDbXref "DOI:10.1681/ASN.2009070759") Annotation(oboInOwl:hasDbXref "DOI:10.1681/ASN.2015050515") terms:description obo:CL_1000850 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Macula densa epithelial cells, as part of the complex nephron structure, play a crucial role in kidney function. These cells, which make up the macula densa, help regulate blood pressure and the filtration rate of the glomerulus by sensing sodium chloride amounts in the kidney tubules. Found where the thick ascending limb of the Loop of Henle touches the afferent arteriole, macula densa epithelial cells are positioned in an optimal location to monitor and respond to changes in the filtrate composition.
+These cells maintain intraglomerular homeostasis. When the sodium chloride concentration is high, macula densa cells respond by secreting adenosine and vasoconstricting the afferent arteriole to decrease the glomerular filtration rate. Conversely, if the sodium chloride concentration in the filtrate is low, the production and release of nitric oxide cause vasodilation to enhance the glomerular filtration rate.
+Macula densa epithelial cells also have a role in tubuloglomerular feedback mechanisms, an essential autoregulatory renal response. They send feedback to the glomerular mesangial cells, allowing constriction or relaxation of the afferent arteriole as needed depending on the content of the filtrate.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000850 "KUPO:0001057")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000850 "https://cellxgene.cziscience.com/cellguide/CL_1000850")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000850 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1000850 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_1000850 "macula densa epithelial cell")
@@ -33971,7 +34664,7 @@ SubClassOf(obo:CL_1000979 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000685
AnnotationAssertion(obo:IAO_0000115 obo:CL_1001005 "An endothelial cell that is part of the glomerular capillary of the kidney.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1001005 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2010.05.015") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.yexcr.2012.02.032") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1523-1755.2005.00260.x") Annotation(oboInOwl:hasDbXref "DOI:10.2337/diacare.28.1.164") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2021.689083") terms:description obo:CL_1001005 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2010.05.015") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.yexcr.2012.02.032") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1523-1755.2005.00260.x") Annotation(oboInOwl:hasDbXref "DOI:10.2337/diacare.28.1.164") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2021.689083") terms:description obo:CL_1001005 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
The glomerular capillary endothelial cell comprises an intrinsic component of the glomerulus in the kidney. Glomeruli contain a network of capillaries where the first step of blood filtration takes place, with glomerular capillary endothelial cells acting as an integral part of this process. Unlike regular endothelial cells that line the vasculature, unique fenestrations (openings) characterize these cells, allowing for enhanced permeability and filtration efficacy.
Together with the glomerular basement membrane and podocytes, the glomerular endothelial cells form the glomerular filtration barrier, which is responsible for blood filtration and therefore critical for removal of waste products, such as urea and creatinine, and excess substances, such as glucose and ions, from the bloodstream. The glomerular capillary endothelial cells' fenestrations permit the free flow of a variety of particles, barring larger, negatively charged proteins like serum albumin, enabling the formation of an ultrafiltrate. This ultrafiltrate is the primitive form of urine, which then passes through the proximal tubule for further processing and ultimately helps maintain systemic fluid and electrolyte balance.
@@ -33989,7 +34682,12 @@ SubClassOf(obo:CL_1001005 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000429
# Class: obo:CL_1001006 (kidney afferent arteriole cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:16990493") Annotation(oboInOwl:hasDbXref "PMID:22733355") Annotation(oboInOwl:hasDbXref "PMID:24066938") Annotation(oboInOwl:hasDbXref "PMID:25834230") obo:IAO_0000115 obo:CL_1001006 "An endothelial cell which is part of the afferent arteriole in the kidney. This cell is responsible for maintaining renal blood flow and glomerular filtration rate.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00424-012-1126-7") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajpregu.00332.2006") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00042.2012") Annotation(oboInOwl:hasDbXref "DOI:10.2174/15701611113116660149") terms:description obo:CL_1001006 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Kidney afferent arteriole cells are specialized cell types found in the renal vasculature, specifically in the afferent arterioles which help in maintaining the renal blood flow and glomerular filtration rate. They are essential for the proper functioning of the kidneys, contributing to the regulation of blood pressure and fluid balance within the organism. Located before the glomerulus, a tiny, intricate network of capillaries within the nephron, these cells help control the expansion or contraction of the arteriole, thus regulating the pressure and flow of blood into the glomerulus.
+Functionally, kidney afferent arteriole cells are largely involved in responding to changes in blood volume and systemic blood pressure. They achieve this by modulating the diameter of the afferent arteriole through a process known as autoregulation. Autoregulation involves two primary mechanisms: the myogenic response and the tubuloglomerular feedback. The myogenic response is essentially the intrinsic ability of the vascular smooth muscle to respond to pressure changes, while the tubuloglomerular feedback is the process where the macula densa cells located near the glomerulus respond to changes in fluid delivery rates in the tubules, sending signals to afferent arterioles to constrict or dilate accordingly. These cells also have significant interaction with renin-containing juxtaglomerular cells, which are located in the wall of afferent arterioles. Juxtaglomerular cells secrete the enzyme renin in response to low blood pressure or sympathetic nerve activity, initiating the renin-angiotensin-aldosterone system cascade that ultimately helps retain sodium and water to increase blood volume and pressure.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001006 "KUPO:0001038")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001006 "https://cellxgene.cziscience.com/cellguide/CL_1001006")
AnnotationAssertion(rdfs:label obo:CL_1001006 "kidney afferent arteriole cell")
EquivalentClasses(obo:CL_1001006 ObjectIntersectionOf(obo:CL_1000891 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004639)))
SubClassOf(obo:CL_1001006 obo:CL_0002681)
@@ -33999,7 +34697,13 @@ SubClassOf(obo:CL_1001006 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000463
# Class: obo:CL_1001009 (kidney efferent arteriole cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001009 "Any kidney arterial blood vessel cell that is part of some renal efferent arteriole.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajpregu.2000.279.2.R629") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00042.2012") Annotation(oboInOwl:hasDbXref "DOI:10.1159/000072054") Annotation(oboInOwl:hasDbXref "DOI:10.1161/01.HYP.29.1.222") Annotation(oboInOwl:hasDbXref "DOI:10.3748/wjg.v12.i34.5429") terms:description obo:CL_1001009 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Kidney efferent arteriole cells are highly adaptable vascular cells that make up the efferent arterioles in the kidney. These units are integral components of the renal microcirculation system, conducting blood away from the glomeruli after filtration occurs. Efferent arterioles directly affect glomerular hydrostatic pressure and, subsequently, the rate of glomerular filtration. They are the downstream channels that ensure the effective transportation of blood to the peritubular capillaries and vasa recta, critical for maintaining fluid balance and electrolyte homeostasis.
+Kidney efferent arteriole cells are exceptional in their ability to perform autoregulation—a critical dynamic control of intrarenal blood flow ensuring stable glomerular filtration rates. This is primarily achieved via myogenic and tubuloglomerular feedback mechanisms, where the cells respond to changes in pressure and the concentration of sodium chloride in the tubular fluid, and constrict or dilate depending on the detected changes.
+Cells associated with the efferent arteriole also respond to several systemic influences. Through complex intracellular signaling pathways, they respond to fluctuations in hormones (like angiotensin II and endothelin) and several other mediators such as nitric oxide and prostaglandins. Their adaptive capability helps maintain homeostasis and ensures the entire system's optimal performance under various physiological conditions. Dysfunctions in kidney efferent arteriole cells can lead to severe pathologies like hypertension and chronic kidney disease.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001009 "KUPO:0001041")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001009 "https://cellxgene.cziscience.com/cellguide/CL_1001009")
AnnotationAssertion(rdfs:label obo:CL_1001009 "kidney efferent arteriole cell")
EquivalentClasses(obo:CL_1001009 ObjectIntersectionOf(obo:CL_1000891 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004640)))
SubClassOf(obo:CL_1001009 obo:CL_0002681)
@@ -34021,7 +34725,13 @@ SubClassOf(obo:CL_1001016 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000516
# Class: obo:CL_1001021 (kidney loop of Henle descending limb epithelial cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001021 "Any kidney loop of Henle epithelial cell that is part of some descending limb of loop of Henle.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00360-018-1164-3") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-021113-170350") Annotation(oboInOwl:hasDbXref "DOI:10.1152/advan.00227.2022") terms:description obo:CL_1001021 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+The kidney loop of Henle descending limb epithelial cells are highly specialized cells that play a crucial role in maintaining the body's salt and water balance. These cells line the descending limb of the loop of Henle, which is a portion of the renal tubule located in the kidneys, an organ responsible for filtering waste products, ions and extra water from the blood and converting them into urine. However, the descending limb epithelial cells are specifically involved in the countercurrent multiplication system, a mechanism to concentrate urine that involves both active and passive transport processes.
+These cells are notably permeable to water but relatively impermeable to solutes, a characteristic that dramatically influences the osmotic gradient in the renal medulla. As filtrate initially descends down the loop of Henle, water gets drawn out due to the increasing osmotic gradient, thereby concentrating the filtrate. Additionally, these epithelial cells are exceptionally thin walled, allowing water to freely diffuse across the membrane.
+Furthermore, the kidney loop of Henle descending limb epithelial cells are inextricably linked to the functioning of numerous diuretic drugs, which work by blocking the reabsorption of water and certain electrolytes in the kidneys, leading to increased urine production to rid the body of excess fluids.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001021 "KUPO:0001053")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001021 "https://cellxgene.cziscience.com/cellguide/CL_1001021")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1001021 cl:kidney_upper_slim)
AnnotationAssertion(rdfs:label obo:CL_1001021 "kidney loop of Henle descending limb epithelial cell")
EquivalentClasses(obo:CL_1001021 ObjectIntersectionOf(obo:CL_1000909 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001289)))
@@ -34048,7 +34758,6 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:12529271") Annotation(ob
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001036 "KUPO:0001068")
AnnotationAssertion(rdfs:label obo:CL_1001036 "vasa recta cell")
EquivalentClasses(obo:CL_1001036 ObjectIntersectionOf(obo:CL_2000008 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004726)))
-SubClassOf(obo:CL_1001036 obo:CL_0002543)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1001036 obo:CL_1000504)
SubClassOf(obo:CL_1001036 obo:CL_2000008)
SubClassOf(obo:CL_1001036 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004726))
@@ -34102,7 +34811,7 @@ SubClassOf(obo:CL_1001068 obo:CL_1000893)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:16990493") Annotation(oboInOwl:hasDbXref "PMID:22733355") Annotation(oboInOwl:hasDbXref "PMID:24066938") Annotation(oboInOwl:hasDbXref "PMID:25834230") obo:IAO_0000115 obo:CL_1001096 "An endothelial cell that lines the interior surface of the afferent arteriole and maintains vascular tone. This cell responds to changing ion concentrations and blood pressure by releasing vasoactive substances, in order to regulate blood flow into the glomeruli, which is essential for glomerular filtration.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1001096 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1046/j.0001-6772.2003.01205.x") Annotation(oboInOwl:hasDbXref "DOI:10.1093/ndt/gfl308") terms:description obo:CL_1001096 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1046/j.0001-6772.2003.01205.x") Annotation(oboInOwl:hasDbXref "DOI:10.1093/ndt/gfl308") terms:description obo:CL_1001096 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Kidney afferent arteriole endothelial cells are a specialized type of cell located within the kidneys, forming the inner lining of the afferent arterioles, which are responsible for delivering blood to the glomeruli - capillary networks responsible for filtration - from where the process of urine formation begins in the nephrons.
The endothelial cells in the kidney afferent arterioles have a key function in regulating the blood flow and filtration. They have autocrine and paracrine signaling capabilities, meaning they can signal to themselves and other nearby cells. They produce nitric oxide, prostacyclin, and endothelin, which are powerful vasodilators and vasoconstrictors that regulate renal blood flow. These cells also engage in the mitigation of kidney injury and inflammation by promoting repair and regeneration, demonstrating the multifaceted roles these cells play in maintaining renal health.")
@@ -34130,7 +34839,7 @@ SubClassOf(obo:CL_1001097 obo:CL_1001066)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001099 "Any endothelial cell that is part of some renal efferent arteriole.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1001099 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.semcdb.2014.08.002") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.semnephrol.2015.01.010") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41581-021-00411-9") Annotation(oboInOwl:hasDbXref "DOI:10.1681/ASN.2019111179") terms:description obo:CL_1001099 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.semcdb.2014.08.002") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.semnephrol.2015.01.010") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41581-021-00411-9") Annotation(oboInOwl:hasDbXref "DOI:10.1681/ASN.2019111179") terms:description obo:CL_1001099 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Kidney efferent arteriole endothelial cells constitute a vital component of the kidney's microvascular system. They are unique endothelial cells found lining the walls of efferent arterioles, which transport blood away from the glomeruli in the kidney.
The primary responsibilities of the kidney efferent arteriole endothelial cells involve controling renal blood flow, regulating glomerular filtration rate (GFR), and managing perfusion pressure. They do this by contracting and relaxing, effectively narrowing and widening the arteriole's lumen thereby controling the volume and rate of blood flow to the peritubular capillaries and creating the pressure gradient necessary for filtration in the glomerulus.
@@ -34246,7 +34955,6 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001126 "KUPO:0001069")
AnnotationAssertion(rdfs:label obo:CL_1001126 "inner renal medulla vasa recta cell")
EquivalentClasses(obo:CL_1001126 ObjectIntersectionOf(obo:CL_1001036 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004776)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1001126 obo:CL_1000617)
-SubClassOf(obo:CL_1001126 obo:CL_1000893)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1001126 obo:CL_1001036)
SubClassOf(obo:CL_1001126 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004776))
@@ -34257,7 +34965,6 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001127 "KUPO:0001070")
AnnotationAssertion(rdfs:label obo:CL_1001127 "outer renal medulla vasa recta cell")
EquivalentClasses(obo:CL_1001127 ObjectIntersectionOf(obo:CL_1001036 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004775)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1001127 obo:CL_1000616)
-SubClassOf(obo:CL_1001127 obo:CL_1000893)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1001127 obo:CL_1001036)
SubClassOf(obo:CL_1001127 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004775))
@@ -34265,7 +34972,7 @@ SubClassOf(obo:CL_1001127 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000477
AnnotationAssertion(obo:IAO_0000115 obo:CL_1001131 "A cell that is part of some vasa recta ascending limb.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1001131 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-0-323-35515-5.00009-9") Annotation(oboInOwl:hasDbXref "DOI:10.1053/j.ajkd.2005.01.008") Annotation(oboInOwl:hasDbXref "DOI:10.1081/jdi-100101958") Annotation(oboInOwl:hasDbXref "DOI:10.1111/apha.12026") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajpregu.00657.2002") terms:description obo:CL_1001131 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-0-323-35515-5.00009-9") Annotation(oboInOwl:hasDbXref "DOI:10.1053/j.ajkd.2005.01.008") Annotation(oboInOwl:hasDbXref "DOI:10.1081/jdi-100101958") Annotation(oboInOwl:hasDbXref "DOI:10.1111/apha.12026") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajpregu.00657.2002") terms:description obo:CL_1001131 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
The vasa recta ascending limb cells are specialized epithelial cells that are part of the vasa recta in the kidney, a crucial component of the renal medulla that functions as a counter-current exchanger to maintain the concentration gradient required for water reabsorption. These particular cells are located in the ascending limb of the vasa recta, which takes blood flow from the medulla back to the cortex.
The primary function of vasa recta ascending limb cells is to preserve the renal medulla's hypertonicity, necessary for the kidney's urine concentration mechanism. Unlike the vasa recta descending limb cells, the venous-like epithelial cells of the ascending vasa recta are highly fenestrated and lack pericyte coverage, which facilitates water reuptake.
@@ -34319,7 +35026,7 @@ SubClassOf(obo:CL_1001145 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000516
# Class: obo:CL_1001209 (inner medulla vasa recta ascending limb cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001209 "Any vasa recta ascending limb cell that is part of some inner medulla vasa recta ascending limb.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001209 "Any vasa recta ascending limb cell that is part of some inner medulla ascending vasa recta.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001209 "KUPO:0001075")
AnnotationAssertion(rdfs:label obo:CL_1001209 "inner medulla vasa recta ascending limb cell")
EquivalentClasses(obo:CL_1001209 ObjectIntersectionOf(obo:CL_1001131 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009092)))
@@ -34329,7 +35036,7 @@ SubClassOf(obo:CL_1001209 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000909
# Class: obo:CL_1001210 (outer medulla vasa recta ascending limb cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001210 "Any vasa recta ascending limb cell that is part of some outer medulla vasa recta ascending limb.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001210 "Any vasa recta ascending limb cell that is part of some outer medulla ascending vasa recta.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001210 "KUPO:0001076")
AnnotationAssertion(rdfs:label obo:CL_1001210 "outer medulla vasa recta ascending limb cell")
EquivalentClasses(obo:CL_1001210 ObjectIntersectionOf(obo:CL_1001131 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009093)))
@@ -34424,7 +35131,7 @@ SubClassOf(obo:CL_1001225 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000123
AnnotationAssertion(obo:IAO_0000115 obo:CL_1001285 "A cell that is part of some vasa recta descending limb.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1001285 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1053/j.ajkd.2005.01.008") Annotation(oboInOwl:hasDbXref "DOI:10.1081/jdi-100101958") Annotation(oboInOwl:hasDbXref "DOI:10.1111/apha.12026#apha12026-bib-0039") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajpregu.00657.2002") terms:description obo:CL_1001285 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1053/j.ajkd.2005.01.008") Annotation(oboInOwl:hasDbXref "DOI:10.1081/jdi-100101958") Annotation(oboInOwl:hasDbXref "DOI:10.1111/apha.12026#apha12026-bib-0039") Annotation(oboInOwl:hasDbXref "DOI:10.1152/ajpregu.00657.2002") terms:description obo:CL_1001285 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Vasa recta descending limb cells are specialized epithelial cells found in the vasa recta, a network of blood vessels in the renal medulla. These cells line the interior surface of the descending limb of the vasa recta and play a crucial role in the filtering and regulation of substances within the blood.
In contrast to vasa recta ascending limb cells, the arterial-like epithelial cells of the descending vasa recta are non-fenestrated and covered by a pericyte layer that regulates the medullary blood flow. They help keeping the body’s fluid and electrolyte balance in check through a process known as countercurrent exchange system, in which the cells of the descending limb are permeable to water but relatively impermeable to solutes, such as sodium and urea. As the blood descends into the medulla along its descending limb, water passively diffuses out of the vasa recta, concentrating the blood in solutes.
@@ -34441,7 +35148,7 @@ SubClassOf(obo:CL_1001285 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000920
# Class: obo:CL_1001286 (inner medulla vasa recta descending limb cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001286 "Any vasa recta descending limb cell that is part of some inner medulla vasa recta descending limb.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001286 "Any vasa recta descending limb cell that is part of some inner medulla descending vasa recta.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001286 "KUPO:0001072")
AnnotationAssertion(rdfs:label obo:CL_1001286 "inner medulla vasa recta descending limb cell")
EquivalentClasses(obo:CL_1001286 ObjectIntersectionOf(obo:CL_1001285 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009089)))
@@ -34451,7 +35158,7 @@ SubClassOf(obo:CL_1001286 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000908
# Class: obo:CL_1001287 (outer medulla vasa recta descending limb cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001287 "Any vasa recta descending limb cell that is part of some outer medulla vasa recta descending limb.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001287 "Any vasa recta descending limb cell that is part of some outer medulla descending vasa recta.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001287 "KUPO:0001073")
AnnotationAssertion(rdfs:label obo:CL_1001287 "outer medulla vasa recta descending limb cell")
EquivalentClasses(obo:CL_1001287 ObjectIntersectionOf(obo:CL_1001285 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009090)))
@@ -34496,8 +35203,15 @@ SubClassOf(obo:CL_1001320 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000005
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1038/s41385-022-00565-0") obo:IAO_0000115 obo:CL_1001428 "A urothelial cell that is part of the urothelium of the urinary bladder.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1001428 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrurol.2011.144") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrurol.2016.13") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41579-020-0324-0") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41585-020-0350-8") Annotation(oboInOwl:hasDbXref "DOI:10.1080/03008880410015165") terms:description obo:CL_1001428 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Bladder urothelial cells form the urothelium in the bladder - a specific type of epithelial tissue that constitutes the inner lining of the bladder and other parts of the urinary tract including the renal pelvis, ureters and urethra. These unique cells are specialized to withstand the highly variable and sometimes harsh conditions present in the urinary system. Their key function is maintaining the barrier integrity of the urinary tract even when exposed to high volumes of urine and its solutes, and they play a crucial role in protecting underlying tissues from damage and infection.
+The bladder urothelial cells exhibit a remarkable spectrum of phenotypic versatility and have an extraordinary capacity to stretch and retract based on the degree of bladder filling and emptying. In their relaxed state, these cells appear large and cuboidal, but upon stretching, they become thinner and exhibit a squamous cell-like appearance. This distinctive feature enables them to adjust to the changes in the urinary bladder volume while remaining impermeable to urinary solutes, thereby preventing a potential toxicity to the bladder wall and infiltration into the bloodstream.
+Apart from their barrier function, bladder urothelial cells also express a number of sensor molecules or respond to thermal, mechanical and chemical stimuli and can release signaling molecules, thereby playing a key role in sensory mechanisms that communicate vital information about the bladder's mechanical state to the nervous system. This communication helps regulate the micturition cycle and maintain urinary continence. Recent studies have also indicated that these cells may play a role in immune responses, highlighting their importance in bladder physiology.
+Altered proliferation and differentiation of bladder urothelial cells are implicated in various diseases and conditions such as bladder cancer, interstitial cystitis, and urinary tract infections.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001428 "KUPO:0001121")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001428 "NCIT:C32210")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001428 "https://cellxgene.cziscience.com/cellguide/CL_1001428")
AnnotationAssertion(oboInOwl:hasNarrowSynonym obo:CL_1001428 "bladder transitional cell")
AnnotationAssertion(oboInOwl:hasNarrowSynonym obo:CL_1001428 "transitional epithelial cell of urinary bladder")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1001428 cl:cellxgene_subset)
@@ -34510,12 +35224,18 @@ SubClassOf(obo:CL_1001428 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000464
# Class: obo:CL_1001430 (urethra urothelial cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001430 "Any urothelial cell that is part of some urethra urothelium.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:23589830") Annotation(oboInOwl:hasDbXref "PMID:36180582") obo:IAO_0000115 obo:CL_1001430 "A urothelial cell that is part of the urethra urothelium. This cell plays a crucial role in maintaining the urethral barrier function, protecting against toxic substances in urine, sensing environmental changes, and defending against pathogen entry.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrurol.2016.13") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41385-022-00565-0") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00030.2012") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00041.2019") terms:description obo:CL_1001430 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Urethra urothelial cells are highly specialized epithelial cells in the urethra, which is a tubelike structure that carries urine from the bladder to the external urethral orifice. Urothelial cells form the urothelium – a stratified, transitional epithelium lining the bladder, ureters, renal pelvis and urethra. These cells are highly adapted to their specific environment and maintain the crucial function of sustaining the urinary tract's core roles, primarily to transit and store urine without auto-corrosion or pathogen proliferation.
+Within the urethra urothelial cells are primarily found in proximal two-thirds of the urethra, while the distal third is lined by stratified squamous epithelial cells. The urothelial cells are renowned for their remarkable impermeability and ability to stretch and recoil during the various stages of urine filling and emptying. They form a tight barrier that prevents reabsorption of harmful byproducts and toxic substances present in the urine, guarding the deeper tissues and bloodstream against potential damage. This is largely attributed to specialized junctions, namely zonulae occludentes or tight junctions, in the umbrella cell layer (one of three layers of the urothelium) that seal the intercellular space between adjacent cells. Together with the urothelial plaque (an apical membrane plaque comprised of uroplakin proteins covering the umbrella cells at the luminal surface), the junctional complexes form a very effective permeability barrier that regulates the passage of water and ion from urine to the underlying tissue.
+A noteworthy feature of urothelial cells is their regulatory and sensory roles involving communication with the underlying layers about the filling and emptying status of the urinary tract. The cells also manage a fine balance between proliferation and differentiation, with the basal cells providing a ready pool of cells to replace the superficial layer when damaged. Their remarkable ability for regeneration and turnover, and their response to signals for repair underpins the durability and functionality of the urothelial tract.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001430 "KUPO:0001124")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001430 "https://cellxgene.cziscience.com/cellguide/CL_1001430")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1001430 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1001430 "urethra urothelial cell")
EquivalentClasses(obo:CL_1001430 ObjectIntersectionOf(obo:CL_0000731 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004787)))
-SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1001430 obo:CL_0000731)
+SubClassOf(obo:CL_1001430 obo:CL_0000731)
SubClassOf(obo:CL_1001430 obo:CL_1000296)
SubClassOf(obo:CL_1001430 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004787))
@@ -34523,7 +35243,7 @@ SubClassOf(obo:CL_1001430 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000478
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001431 "Any renal principal cell that is part of some collecting duct of renal tubule.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1001431 obo:NCBITaxon_9606)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s11906-015-0538-0") Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-0-12-386456-7.05402-2") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2022.106261") Annotation(oboInOwl:hasDbXref "DOI:10.1073/pnas.1710964114") terms:description obo:CL_1001431 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s11906-015-0538-0") Annotation(oboInOwl:hasDbXref "DOI:10.1016/B978-0-12-386456-7.05402-2") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2022.106261") Annotation(oboInOwl:hasDbXref "DOI:10.1073/pnas.1710964114") terms:description obo:CL_1001431 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
The kidney collecting duct principal cell is a highly specialized type of cell found in the late distal convoluted tubule and collecting duct of the kidney's nephron. Principal cells are located at the final segments of the renal tubules, where they play a pivotal role in key homeostatic processes.
One of their fundamental functions of kidney collecting duct principal cells is the regulation of water reabsorption, which is mediated by aquaporins (water channel proteins). Antidiuretic hormones, such as vasopressin, can stimulate the redistribution of these water channels from an intracellular pools to the apical plasma membrane of the principal cell; translocation of aquaporin (specifically, AQP2) is associated with an increase of osmotic water permeability. The water reabsorption affects the concentration of the final urine; these cells are therefore directly involved in the maintenance of the body's fluid balance.
@@ -34541,8 +35261,14 @@ SubClassOf(obo:CL_1001431 obo:CL_1000454)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001432 "Any renal intercalated cell that is part of some collecting duct of renal tubule.")
AnnotationAssertion(obo:RO_0002175 obo:CL_1001432 obo:NCBITaxon_9606)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/978-3-211-99390-3_106") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physiol.00008.2011") Annotation(oboInOwl:hasDbXref "DOI:10.1152/physrev.00011.2019") Annotation(oboInOwl:hasDbXref "DOI:10.2215/CJN.08880914") Annotation(oboInOwl:hasDbXref "DOI:10.3390/diseases2020071") terms:description obo:CL_1001432 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+The kidney collecting duct intercalated cell, otherwise referred to simply as the intercalated cell, is a specialized epithelial cell type primarily found in the kidney's collecting duct system. It is among the main cells that line this final component of the nephron, crucial in the physiological system that maintains acid-base homeostasis. This unique cell type comes in mainly three subtypes as per the localization of their proton pumps: type A, type B, and non-A, non-B cells. Each subtype plays different roles in regulating acid-base balance and electrolyte homeostasis in the body under varying physiological conditions.
+Type A intercalated cells reabsorb bicarbonate and secrete protons into urine, leading to the production of acidic urine. These cells are typically prevalent on the renal cortex and function particularly in states of metabolic acidosis or potassium depletion. On the other hand, type B intercalated cells secrete bicarbonate and reabsorb protons; thus, they are crucial in alkaline urine production and potassium conservation. These cells are essential to counter metabolic alkalosis or situations of potassium surplus. The non-A, non-B cells have the characteristic features of both type A and B cells, but play a prominent role under conditions of chronically elevated aldosterone and angiotensin II levels.
+Through their differentiated roles, intercalated cells also facilitate the reabsorption of sodium and chloride ions, and water to maintain osmolarity. These cells' activity is finely regulated by hormonal signals like aldosterone, angiotensin II, vasopressin, and the parathyroid hormone. Intercalated cell activity can undergo a significant transformation under pathological conditions, and their dysregulation is associated with diseases such as distal renal tubular acidosis, hypertension, and chronic kidney disease.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001432 "KUPO:0001129")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001432 "http://en.wikipedia.org/wiki/Collecting_duct_system#Intercalated_cells")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001432 "https://cellxgene.cziscience.com/cellguide/CL_1001432")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1001432 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_1001432 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_1001432 "kidney collecting duct intercalated cell")
@@ -34568,9 +35294,9 @@ SubClassOf(obo:CL_1001433 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000001
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18603310") obo:IAO_0000115 obo:CL_1001434 "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons")
AnnotationAssertion(rdfs:label obo:CL_1001434 "olfactory bulb interneuron")
EquivalentClasses(obo:CL_1001434 ObjectIntersectionOf(obo:CL_0000099 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002264)))
-SubClassOf(obo:CL_1001434 obo:BFO_0000002)
+SubClassOf(obo:CL_1001434 obo:CL_0000099)
SubClassOf(obo:CL_1001434 obo:CL_0000101)
-SubClassOf(obo:CL_1001434 obo:CL_0000402)
+SubClassOf(obo:CL_1001434 obo:CL_0012001)
SubClassOf(obo:CL_1001434 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002264))
SubClassOf(obo:CL_1001434 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002264))
@@ -34604,9 +35330,11 @@ SubClassOf(obo:CL_1001437 obo:CL_0002487)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MP:0004297") obo:IAO_0000115 obo:CL_1001451 "A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord.")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MP:0004297") oboInOwl:hasExactSynonym obo:CL_1001451 "proprioceptive neuron")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_1001451 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1001451 "sensory neuron of dorsal root ganglion")
EquivalentClasses(obo:CL_1001451 ObjectIntersectionOf(obo:CL_0000101 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000044)))
SubClassOf(obo:CL_1001451 obo:CL_0000006)
+SubClassOf(obo:CL_1001451 obo:CL_3000004)
SubClassOf(obo:CL_1001451 obo:CL_4023168)
SubClassOf(obo:CL_1001451 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000044))
SubClassOf(obo:CL_1001451 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000044))
@@ -34638,9 +35366,8 @@ SubClassOf(obo:CL_1001502 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0004186
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MP:0009955") obo:IAO_0000115 obo:CL_1001503 "The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala.")
AnnotationAssertion(rdfs:label obo:CL_1001503 "olfactory bulb tufted cell")
-SubClassOf(obo:CL_1001503 obo:BFO_0000002)
-SubClassOf(obo:CL_1001503 obo:CL_0000540)
-SubClassOf(obo:CL_1001503 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005376))
+SubClassOf(obo:CL_1001503 obo:CL_0012001)
+SubClassOf(obo:CL_1001503 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005376))
# Class: obo:CL_1001505 (parvocellular neurosecretory cell)
@@ -34668,20 +35395,26 @@ SubClassOf(obo:CL_1001509 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061537))
# Class: obo:CL_1001516 (intestinal enteroendocrine cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MP:0010802") obo:IAO_0000115 obo:CL_1001516 "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.coph.2013.09.008") Annotation(oboInOwl:hasDbXref "DOI:10.1038/mi.2017.73") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41574-019-0168-8") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1365-2613.2011.00767.x") Annotation(oboInOwl:hasDbXref "DOI:10.1146/annurev-physiol-021115-105439") terms:description obo:CL_1001516 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Intestinal enteroendocrine cells are a highly specialized cell type found within the gastrointestinal epithelium. They account for approximately 1% of the intestinal epithelial cells in what is known as the largest endocrine organ in the human body. Intestinal enteroendocrine cells exhibit an exceptional diversity, both in terms of their secretory products and their distribution along the intestines, varying from the small intestine to the colon.
+The primary function of intestinal enteroendocrine cells is to maintain gut physiology and homeostasis. They are known for their hormone production and are the source of numerous bioactive molecules including somatostatin, serotonin, cholecystokinin, glucose-dependent insulinotropic peptide, motilin, neurotensin, and others. These hormones and neuropeptides act in autocrine, paracrine, or endocrine signaling, impacting various functions including intestinal motility, secretion, nutrient absorption, and gut barrier functions.
+Intestinal enteroendocrine cells also serve as the body's frontline of defense, playing an integral role in surveillance against lumen-occurring hazards including pathogen attack. Enteroendocrine cells are divided into ‘closed type’ and ‘open type’. Closed type cells are located close to the basal membrane and do not reach the lumen of the gut. In contrast, the apical side of the open-type intestinal enteroendocrine cells is directly exposed to luminal contents and thus can recognize bacterial metabolites and dietary nutrients. In response, these cells can modulate the immune system responses and thereby function as a key communicator between the gut microbiota and the host.")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001516 "https://cellxgene.cziscience.com/cellguide/CL_1001516")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1001516 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1001516 "intestinal enteroendocrine cell")
-EquivalentClasses(obo:CL_1001516 ObjectIntersectionOf(obo:CL_0000164 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001242)))
+EquivalentClasses(obo:CL_1001516 ObjectIntersectionOf(obo:CL_0000164 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001277)))
SubClassOf(obo:CL_1001516 obo:CL_0000164)
SubClassOf(obo:CL_1001516 obo:CL_0002563)
+SubClassOf(obo:CL_1001516 ObjectSomeValuesFrom(obo:RO_0002207 obo:CL_4052006))
# Class: obo:CL_1001517 (stomach enteroendocrine cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MP:0010803") obo:IAO_0000115 obo:CL_1001517 "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach.")
AnnotationAssertion(rdfs:label obo:CL_1001517 "stomach enteroendocrine cell")
-EquivalentClasses(obo:CL_1001517 ObjectIntersectionOf(obo:CL_0000164 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001160)))
+EquivalentClasses(obo:CL_1001517 ObjectIntersectionOf(obo:CL_0000164 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000945)))
SubClassOf(obo:CL_1001517 obo:CL_0000164)
-SubClassOf(obo:CL_1001517 obo:CL_0002659)
-SubClassOf(obo:CL_1001517 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001160))
+SubClassOf(obo:CL_1001517 obo:CL_0002178)
# Class: obo:CL_1001561 (vomeronasal sensory neuron)
@@ -34706,6 +35439,7 @@ AnnotationAssertion(owl:deprecated obo:CL_1001566 "true"^^xsd:boolean)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FBC:Autogenerated") obo:IAO_0000115 obo:CL_1001567 "Any endothelial cell of vascular tree that is part of some lung.")
AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_1001567 "endothelial cell of lung")
AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_1001567 "pulmonary vessel endothelial cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_1001567 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1001567 "lung endothelial cell")
EquivalentClasses(obo:CL_1001567 ObjectIntersectionOf(obo:CL_0002139 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002048)))
SubClassOf(obo:CL_1001567 obo:CL_0002139)
@@ -34868,7 +35602,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1261") oboInOwl:has
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1261") oboInOwl:hasRelatedSynonym obo:CL_1001582 "lateral ventricle neuronal cells")
AnnotationAssertion(rdfs:label obo:CL_1001582 "lateral ventricle neuron")
EquivalentClasses(obo:CL_1001582 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002285)))
-SubClassOf(obo:CL_1001582 obo:CL_2000029)
+SubClassOf(obo:CL_1001582 obo:CL_0012001)
SubClassOf(obo:CL_1001582 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002285))
# Class: obo:CL_1001583 (obsolete breast adipocyte)
@@ -34891,7 +35625,6 @@ AnnotationAssertion(rdfs:label obo:CL_1001585 "appendix glandular cell")
EquivalentClasses(obo:CL_1001585 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001154)))
SubClassOf(obo:CL_1001585 obo:CL_0002658)
SubClassOf(obo:CL_1001585 obo:CL_1000405)
-SubClassOf(obo:CL_1001585 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009697))
# Class: obo:CL_1001586 (mammary gland glandular cell)
@@ -34907,15 +35640,16 @@ SubClassOf(obo:CL_1001586 obo:CL_0000152)
SubClassOf(obo:CL_1001586 obo:CL_0002327)
SubClassOf(obo:CL_1001586 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003244))
-# Class: obo:CL_1001587 (uterine cervix glandular cell)
+# Class: obo:CL_1001587 (uterine cervix secretory cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "NPX:PDR") obo:IAO_0000115 obo:CL_1001587 "Glandular cell of uterine cervix epithelium.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001587 "CALOHA:TS-1273")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1273") oboInOwl:hasRelatedSynonym obo:CL_1001587 "cervix glandular cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1273") oboInOwl:hasRelatedSynonym obo:CL_1001587 "cervix, uterine glandular cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1273") oboInOwl:hasRelatedSynonym obo:CL_1001587 "cervix, uterine glandular cells")
-AnnotationAssertion(rdfs:label obo:CL_1001587 "uterine cervix glandular cell")
-EquivalentClasses(obo:CL_1001587 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000002)))
+AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_1001587 "uterine cervix glandular cell")
+AnnotationAssertion(rdfs:label obo:CL_1001587 "uterine cervix secretory cell")
+EquivalentClasses(obo:CL_1001587 ObjectIntersectionOf(obo:CL_1100001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000002)))
SubClassOf(obo:CL_1001587 obo:CL_0002535)
SubClassOf(obo:CL_1001587 obo:CL_1001591)
@@ -34929,39 +35663,40 @@ EquivalentClasses(obo:CL_1001588 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeV
SubClassOf(obo:CL_1001588 obo:CL_0002658)
SubClassOf(obo:CL_1001588 obo:CL_0011108)
-# Class: obo:CL_1001589 (duodenum glandular cell)
+# Class: obo:CL_1001589 (duodenum secretory cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "NPX:PDR") obo:IAO_0000115 obo:CL_1001589 "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001589 "CALOHA:TS-1275")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1275") oboInOwl:hasRelatedSynonym obo:CL_1001589 "duodenum glandular cells")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1275") oboInOwl:hasNarrowSynonym obo:CL_1001589 "duodenum glandular cells")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1001589 cl:cellxgene_subset)
-AnnotationAssertion(rdfs:label obo:CL_1001589 "duodenum glandular cell")
-EquivalentClasses(obo:CL_1001589 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002114)))
+AnnotationAssertion(rdfs:label obo:CL_1001589 "duodenum secretory cell")
+EquivalentClasses(obo:CL_1001589 ObjectIntersectionOf(obo:CL_1100001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002114)))
SubClassOf(obo:CL_1001589 obo:CL_1001598)
SubClassOf(obo:CL_1001589 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008346))
-# Class: obo:CL_1001590 (epididymis glandular cell)
+# Class: obo:CL_1001590 (epididymis secretory cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "NPX:PDR") obo:IAO_0000115 obo:CL_1001590 "Glandular cell of epididymal epithelium.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001590 "CALOHA:TS-1276")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1276") oboInOwl:hasRelatedSynonym obo:CL_1001590 "epididymal glandular cell")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1276") oboInOwl:hasRelatedSynonym obo:CL_1001590 "epididymis glandular cells")
-AnnotationAssertion(rdfs:label obo:CL_1001590 "epididymis glandular cell")
-EquivalentClasses(obo:CL_1001590 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001301)))
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1276") oboInOwl:hasRelatedSynonym obo:CL_1001590 "epididymis glandular cell")
+AnnotationAssertion(rdfs:label obo:CL_1001590 "epididymis secretory cell")
+EquivalentClasses(obo:CL_1001590 ObjectIntersectionOf(obo:CL_1100001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001301)))
SubClassOf(obo:CL_1001590 obo:CL_0000068)
-SubClassOf(obo:CL_1001590 obo:CL_0000150)
+SubClassOf(obo:CL_1001590 obo:CL_1100001)
SubClassOf(obo:CL_1001590 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004544))
-# Class: obo:CL_1001591 (oviduct glandular cell)
+# Class: obo:CL_1001591 (oviduct secretory cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "HPA:HPA") Annotation(oboInOwl:hasDbXref "NPX:PDR") obo:IAO_0000115 obo:CL_1001591 "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001591 "CALOHA:TS-1277")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1277") oboInOwl:hasRelatedSynonym obo:CL_1001591 "fallopian tube glandular cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1277") oboInOwl:hasRelatedSynonym obo:CL_1001591 "fallopian tube glandular cells")
+AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_1001591 "oviduct glandular cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1277") oboInOwl:hasRelatedSynonym obo:CL_1001591 "uterine tube glandular cell")
-AnnotationAssertion(rdfs:label obo:CL_1001591 "oviduct glandular cell")
-EquivalentClasses(obo:CL_1001591 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000993)))
-SubClassOf(obo:CL_1001591 obo:CL_0000150)
+AnnotationAssertion(rdfs:label obo:CL_1001591 "oviduct secretory cell")
+EquivalentClasses(obo:CL_1001591 ObjectIntersectionOf(obo:CL_1100001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000993)))
+SubClassOf(obo:CL_1001591 obo:CL_1100001)
SubClassOf(obo:CL_1001591 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004804))
# Class: obo:CL_1001592 (gallbladder glandular cell)
@@ -34979,14 +35714,14 @@ SubClassOf(obo:CL_1001592 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000202
# Class: obo:CL_1001593 (parathyroid glandular cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "HPA:HPA") Annotation(oboInOwl:hasDbXref "NPX:PDR") obo:IAO_0000115 obo:CL_1001593 "Glandular cell of parathyroid epithelium. Example: Parathyroid chief cell and parathyroid oxyphil cells.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "HPA:HPA") Annotation(oboInOwl:hasDbXref "NPX:PDR") obo:IAO_0000115 obo:CL_1001593 "Glandular (secretory) cell of parathyroid epithelium.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001593 "CALOHA:TS-1279")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1279") oboInOwl:hasRelatedSynonym obo:CL_1001593 "parathyroid gland glandular cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1279") oboInOwl:hasRelatedSynonym obo:CL_1001593 "parathyroid gland glandular cells")
AnnotationAssertion(rdfs:label obo:CL_1001593 "parathyroid glandular cell")
EquivalentClasses(obo:CL_1001593 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001132)))
SubClassOf(obo:CL_1001593 obo:CL_0000150)
-SubClassOf(obo:CL_1001593 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0011197))
+SubClassOf(obo:CL_1001593 obo:CL_0002260)
# Class: obo:CL_1001595 (rectum glandular cell)
@@ -35015,7 +35750,7 @@ SubClassOf(obo:CL_1001596 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000480
# Class: obo:CL_1001597 (seminal vesicle glandular cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "NPX:PDR") obo:IAO_0000115 obo:CL_1001597 "Glandular cell of seminal vesicle epithelium.")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/978-3-030-32300-4_26") Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00265-006-0178-0") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1439-0272.1992.tb02636.x") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK499854/") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/seminal-vesicle") terms:description obo:CL_1001597 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/978-3-030-32300-4_26") Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00265-006-0178-0") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1439-0272.1992.tb02636.x") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK499854/") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/seminal-vesicle") terms:description obo:CL_1001597 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Seminal vesicle glandular cells belong to a specialized group of epithelial cells that form the internal lining of the seminal vesicles, a pair of male reproductive organs. These cells are located within the complex tubuloalveolar glands that make up the seminal vesicles and are known for their unique pseudostratified columnar epithelium structure.
The primary function of these cells is the secretion of a variety of substances that ultimately constitute around 70% of the fluid volume of semen. Seminal cells produce a high-fructose fluid that serves as an energy source for the spermatozoa and promotes their motility. They also secrete other essential substances like proteins, enzymes, vitamin C, prostaglandins, and various other compounds. Collectively, these substances help in the nourishment, protection, and transportation of the spermatozoa throughout the male reproductive system and during the ejaculation process.
@@ -35030,18 +35765,18 @@ SubClassOf(obo:CL_1001597 obo:CL_0000068)
SubClassOf(obo:CL_1001597 obo:CL_0000150)
SubClassOf(obo:CL_1001597 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004805))
-# Class: obo:CL_1001598 (small intestine glandular cell)
+# Class: obo:CL_1001598 (small intestine secretory cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "NCI_Thesaurus:Small_Intestinal_Glandular_Cell") Annotation(oboInOwl:hasDbXref "NPX:PDR") obo:IAO_0000115 obo:CL_1001598 "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) .")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001598 "CALOHA:TS-1286")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001598 "FMA:86928")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1286") oboInOwl:hasNarrowSynonym obo:CL_1001598 "small intestinal glandular cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1286") oboInOwl:hasRelatedSynonym obo:CL_1001598 "small bowel glandular cell")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1286") oboInOwl:hasRelatedSynonym obo:CL_1001598 "small intestinal glandular cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-1286") oboInOwl:hasRelatedSynonym obo:CL_1001598 "small intestine glandular cells")
-AnnotationAssertion(rdfs:label obo:CL_1001598 "small intestine glandular cell")
-EquivalentClasses(obo:CL_1001598 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002108)))
-SubClassOf(obo:CL_1001598 obo:CL_0000150)
+AnnotationAssertion(rdfs:label obo:CL_1001598 "small intestine secretory cell")
+EquivalentClasses(obo:CL_1001598 ObjectIntersectionOf(obo:CL_1100001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002108)))
SubClassOf(obo:CL_1001598 obo:CL_0002254)
+SubClassOf(obo:CL_1001598 obo:CL_1100001)
SubClassOf(obo:CL_1001598 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001902))
# Class: obo:CL_1001599 (pancreas exocrine glandular cell)
@@ -35075,7 +35810,13 @@ SubClassOf(obo:CL_1001601 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000123
# Class: obo:CL_1001602 (cerebral cortex endothelial cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "NPX:PDR") obo:IAO_0000115 obo:CL_1001602 "A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nbt.2247") Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrn1824") Annotation(oboInOwl:hasDbXref "DOI:10.1177/0271678X156179") Annotation(oboInOwl:hasDbXref "DOI:10.1186/s12987-020-00230-3") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fnins.2023.1047778") terms:description obo:CL_1001602 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Cerebral cortex endothelial cells are unique endothelial cells responsible for the formation and regulation of the blood-brain barrier (BBB), a specialized structure that separates the circulating blood from the cerebral neural tissue. These cells line the inner surface of nearly all blood vessels that irrigate the cerebral cortex, the outermost layer of the brain involved with complex cognitive functions such as thought, perception, and memory formation. Cerebral cortex endothelial cells are integral to maintaining brain health and function due to their role in regulating brain microenvironment and controlling the passage of essential molecules and cells.
+The endothelial cells in the cerebral cortex are distinctive due to their highly selective permeability, largely attributable to the existence of unique tight junctions which maintain the barrier function of the BBB. The tightly interconnected structures of these cells prevent most substances from freely diffusing into the brain tissue, ensuring that harmful agents such as toxins, pathogens, or peripheral immune cells don't reach the brain and compromise its function. These cells also express multiple transporters and enzymes, allowing the selective entry of necessary nutrients and metabolites while excluding toxic substances.
+Cerebral cortex endothelial cells also participate in neurovascular coupling, a process where localized neuronal activity increases cerebral blood flow to satisfy the local metabolic demands. The endothelial cells work in coordination with neurons and other cell types such as astrocytes and pericytes to mediate this process. They have been thought to regulate local blood flow by releasing substances in response to neuronal activity. Additionally, these cells are involved in many pathological conditions. Breakdown or dysfunction of the BBB often marked by altered endothelial cell function is linked to numerous neurological disorders including stroke, multiple sclerosis, Alzheimer’s disease, and brain tumors.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001602 "CALOHA:TS-2372")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001602 "https://cellxgene.cziscience.com/cellguide/CL_1001602")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-2372") oboInOwl:hasRelatedSynonym obo:CL_1001602 "cerebral cortex endothelial cells")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-2372") oboInOwl:hasRelatedSynonym obo:CL_1001602 "endothelial cells of cerebral cortex")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1001602 cl:cellxgene_subset)
@@ -35089,7 +35830,13 @@ SubClassOf(obo:CL_1001602 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_001369
# Class: obo:CL_1001603 (lung macrophage)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "HPA:HPA") Annotation(oboInOwl:hasDbXref "NPX:PDR") obo:IAO_0000115 obo:CL_1001603 "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/JLB.3RU0720-418R") Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.immuni.2022.08.010") Annotation(oboInOwl:hasDbXref "DOI:10.1189/jlb.70.2.163") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2021.753940/full") Annotation(oboInOwl:hasDbXref "DOI:10.3390/cells10040897") terms:description obo:CL_1001603 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Lung macrophages refer to macrophage populations in the lungs, including the tissue-resident alveolar macrophages and interstitial macrophages, located in the air spaces and the connective tissue of the lung, respectively, and recruited macrophages. They are important in maintaining tissue homeostasis and immunity.
+The primary function of lung macrophages is to patrol and maintain the pulmonary system, where they serve as the first line of defense against airborne pathogens and inhaled particles. They perform phagocytosis of pathogens, particulate matter, dead cells, and other cellular debris from the lungs to maintain clear air passages and optimize gas exchange. They may also participate in tissue repair and the resolution of inflammation following injury.
+Lung macrophages also play a critical role in immune regulation. They help to initiate an immune response by secreting cytokines and other inflammatory mediators and by presenting antigens from the pathogens they have engulfed to induce T cell responses. However, if activated improperly, lung macrophages can contribute to inflammatory diseases of the lung such as chronic obstructive pulmonary disease (COPD) or asthma.")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001603 "CALOHA:TS-0576")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1001603 "https://cellxgene.cziscience.com/cellguide/CL_1001603")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CALOHA:TS-0576") oboInOwl:hasRelatedSynonym obo:CL_1001603 "lung macrophages")
AnnotationAssertion(oboInOwl:inSubset obo:CL_1001603 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_1001603 "lung macrophage")
@@ -35159,6 +35906,16 @@ EquivalentClasses(obo:CL_1001611 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeV
SubClassOf(obo:CL_1001611 obo:CL_2000029)
SubClassOf(obo:CL_1001611 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002037))
+# Class: obo:CL_1100001 (secretory epithelial cell)
+
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref ) obo:IAO_0000115 obo:CL_1100001 "An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules.")
+AnnotationAssertion(terms:contributor obo:CL_1100001 )
+AnnotationAssertion(terms:date obo:CL_1100001 "2024-07-21T09:24:44Z"^^xsd:dateTime)
+AnnotationAssertion(rdfs:label obo:CL_1100001 "secretory epithelial cell"@en)
+EquivalentClasses(obo:CL_1100001 ObjectIntersectionOf(obo:CL_0000066 obo:CL_0000151))
+SubClassOf(obo:CL_1100001 obo:CL_0000066)
+SubClassOf(obo:CL_1100001 obo:CL_0000151)
+
# Class: obo:CL_2000000 (epidermal melanocyte)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:TermGenie") obo:IAO_0000115 obo:CL_2000000 "Any melanocyte that is part of a epidermis.")
@@ -35188,12 +35945,18 @@ SubClassOf(obo:CL_2000001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000017
# Class: obo:CL_2000002 (decidual cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "BTO:0002770") Annotation(oboInOwl:hasDbXref "NCIT:C32429") Annotation(oboInOwl:hasDbXref "PMID:30013421") Annotation(oboInOwl:hasDbXref "PMID:30429548") Annotation(oboInOwl:hasDbXref "Wiki:Decidual_cells&oldid=937509751") Annotation(oboInOwl:hasDbXref "Wiki:Decidualization&oldid=908981933") obo:IAO_0000115 obo:CL_2000002 "A specialized, enlarged, connective tissue cell of the decidua with enlarged nucleus, dense membrane‐bound secretory granules and cytoplasmic accumulation of glycogen and lipid droplets. These cells develop by the transformation of endometrial stromal cells during decidualization.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/rmb2.12088") Annotation(oboInOwl:hasDbXref "DOI:10.1093/humupd/dmw004") Annotation(oboInOwl:hasDbXref "DOI:10.1111/j.1749-6632.2010.05938.x") Annotation(oboInOwl:hasDbXref "DOI:10.3390/ijms21114092") terms:description obo:CL_2000002 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Decidual cells, originating from the endometrial lining in the uterus, undergo significant transformations during pregnancy and are integral to its preparation and maintenance. Their conversion from endometrial fibroblast to a secretory phenotype, known as decidualization, occurs as a normal process in the menstrual cycle or in response to embryo implantation.
+With crucial roles in regulating maternal immune responses and placental development, decidual cells have a twofold function: preventing rejection of the conceptus by the mother's immune system and guiding placental development to avoid excessive trophoblast invasion leading to pre-eclampsia. During decidualization, these cells secrete proteins and growth factors supporting embryo implantation and sustaining early pregnancy. Furthermore, decidual cells modulate the activities of natural killer cells, macrophages, and T cells in the uterus, maintaining a balance of pro-inflammatory and anti-inflammatory conditions during pregnancy.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_2000002 "2014-02-20T23:06:41Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_2000002 "BTO:0002770")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_2000002 "BTO:0005756")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_2000002 "NCIT:C32429")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_2000002 "https://cellxgene.cziscience.com/cellguide/CL_2000002")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "BTO:0002770") Annotation(oboInOwl:hasDbXref "NCIT:C32429") oboInOwl:hasExactSynonym obo:CL_2000002 "decidua cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "BTO:0005756") Annotation(oboInOwl:hasDbXref "PMID:11719592") oboInOwl:hasExactSynonym obo:CL_2000002 "decidual stromal cell")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31907034") oboInOwl:hasExactSynonym obo:CL_2000002 "decidualized endometrial stromal cell")
AnnotationAssertion(oboInOwl:id obo:CL_2000002 "CL:2000002")
AnnotationAssertion(oboInOwl:inSubset obo:CL_2000002 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_2000002 "decidual cell")
@@ -35254,6 +36017,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:TermGenie") obo:IAO_00001
AnnotationAssertion(terms:contributor obo:CL_2000008 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_2000008 "2014-06-04T15:07:42Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:id obo:CL_2000008 "CL:2000008")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_2000008 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_2000008 "microvascular endothelial cell")
EquivalentClasses(obo:CL_2000008 ObjectIntersectionOf(obo:CL_0000071 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008339)))
SubClassOf(obo:CL_2000008 obo:CL_0000071)
@@ -35284,7 +36048,12 @@ SubClassOf(obo:CL_2000010 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000206
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:TermGenie") obo:IAO_0000115 obo:CL_2000011 "Any endothelial cell of lymphatic vessel that is part of a dermis.")
AnnotationAssertion(terms:contributor obo:CL_2000011 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41423-023-01042-9") Annotation(oboInOwl:hasDbXref "DOI:10.1038/s41467-019-14127-9") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2023.1235812") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2020.00509") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fphys.2020.577584") terms:description obo:CL_2000011 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+A dermis lymphatic vessel endothelial cell is a specialized type of cell that lines the interior surface of lymphatic vessels present in the dermal layer of the skin. These cells are organized into a single layer, forming an integral part of the lymphatic system which acts as the body's secondary circulatory system. The primary function of dermis lymphatic vessel endothelial cells is to facilitate the transportation and regulation of the lymph fluid within the dermis. They act as a barrier, contributing to fluid homeostasis, lipid transport, and immune cell trafficking. These cells are uniquely equipped to let fluid and larger molecules, including proteins and immune cells, into the lymphatic vessels from the surrounding interstitial space. This is enabled by the specialized junctions between the endothelial cells and the presence of primary lymphatic valves that prevent the backflow of lymph.
+Another paramount role of dermis lymphatic vessel endothelial cells is their involvement in immune response. By interacting with white blood cells, especially T-cells and dendritic cells, they can mediate local immune surveillance and contribute to both innate and adaptive immune responses. These cells are also implicated in a variety of pathological conditions, including lymphedema and metastasis in cancer.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_2000011 "2014-06-04T15:15:08Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_2000011 "https://cellxgene.cziscience.com/cellguide/CL_2000011")
AnnotationAssertion(oboInOwl:id obo:CL_2000011 "CL:2000011")
AnnotationAssertion(rdfs:label obo:CL_2000011 "dermis lymphatic vessel endothelial cell")
EquivalentClasses(obo:CL_2000011 ObjectIntersectionOf(obo:CL_0002138 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002067)))
@@ -35398,7 +36167,13 @@ SubClassOf(obo:CL_2000020 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000008
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:TermGenie") obo:IAO_0000115 obo:CL_2000021 "Any native cell that is part of a sebaceous gland.")
AnnotationAssertion(terms:contributor obo:CL_2000021 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.jid.2016.10.017") Annotation(oboInOwl:hasDbXref "DOI:10.1080/19381980.2017.1375636") Annotation(oboInOwl:hasDbXref "DOI:10.4161/derm.1.2.8472") Annotation(oboInOwl:hasDbXref "https://doi.org/10.2147/CLEP.S323744") Annotation(oboInOwl:hasDbXref "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/sebum") terms:description obo:CL_2000021 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Sebaceous gland cells, also known as sebocytes, are small, oil-producing glands present in the skin of mammals. These specialized cells are predominantly located in the dermis, particularly on the face, scalp, and upper body.
+The primary function of sebaceous gland cells is the production and secretion of sebum, a complex mixture of lipids including triglycerides, wax esters, squalene, and metabolites of fat-soluble vitamins (such as vitamin E), as well as free fatty acids. The production process involves a unique form of programmed cell death called holocrine secretion. In this process, as sebaceous gland cells mature, they progressively accumulate lipid droplets, before ultimately disintegrating and releasing their lipid-rich contents into the gland's ductal system.
+The sebum generated by these cells serves multiple purposes. It acts as a waterproofing agent, preventing excessive wetting or drying of the skin and averaging skin's water-holding capacity. Sebum also has antimicrobial properties, providing a natural defense barrier against certain bacterial and fungal species. Additionally, it contributes to the skin’s suppleness and prevents it from becoming brittle. An overproduction or imbalance of sebaceous gland cells can lead to common skin disorders, such as acne, seborrhea, or rosacea, illustrating their importance in skin health.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_2000021 "2014-06-24T23:17:00Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_2000021 "https://cellxgene.cziscience.com/cellguide/CL_2000021")
AnnotationAssertion(oboInOwl:id obo:CL_2000021 "CL:2000021")
AnnotationAssertion(oboInOwl:inSubset obo:CL_2000021 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_2000021 "sebaceous gland cell")
@@ -35468,7 +36243,6 @@ AnnotationAssertion(oboInOwl:id obo:CL_2000027 "CL:2000027")
AnnotationAssertion(rdfs:label obo:CL_2000027 "cerebellum basket cell")
EquivalentClasses(obo:CL_2000027 ObjectIntersectionOf(obo:CL_0000118 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002037)))
SubClassOf(obo:CL_2000027 obo:CL_0000118)
-SubClassOf(obo:CL_2000027 obo:CL_0000402)
SubClassOf(obo:CL_2000027 obo:CL_1001611)
# Class: obo:CL_2000028 (cerebellum glutamatergic neuron)
@@ -35499,6 +36273,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:TermGenie") obo:IAO_00001
AnnotationAssertion(terms:contributor obo:CL_2000030 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_2000030 "2014-06-25T01:17:50Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:id obo:CL_2000030 "CL:2000030")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_2000030 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_2000030 "hypothalamus cell")
EquivalentClasses(obo:CL_2000030 ObjectIntersectionOf(obo:CL_0000000 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001898)))
SubClassOf(obo:CL_2000030 obo:CL_0002319)
@@ -35511,9 +36286,11 @@ AnnotationAssertion(terms:contributor obo:CL_2000031 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.peptides.2018.05.012") Annotation(oboInOwl:hasDbXref "DOI:10.1126/science.aam5894") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK535355") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK572070/") terms:description obo:CL_2000046 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+Ventricular cardiac muscle cells, or cardiomyocytes, are specialized cells found in the ventricular walls of the heart. They exhibit unique features, including centrally located nuclei, robust cytoskeletal structures, high mitochondria content, and intercalated discs, which contribute to their efficient pumping of blood throughout the body.
+The main role of ventricular cardiac muscle cells is to coordinate contractions, enabling the heart to pump blood throughout the body. This is achieved through controlled ion movement across cell membranes, generating rhythmic electrical signals called action potentials. Intercalated discs between these cells aid synchronized contractions by allowing efficient signal spread through gap junctions. The high mitochondrial content ensures a constant energy supply for this ongoing contraction cycle.
+Ventricular cardiac muscle cells contribute not only mechanically but also biochemically by secreting essential hormones like atrial natriuretic peptide and B-type natriuretic peptide for blood pressure regulation and cardiac remodeling. These cells exhibit low turnover under normal conditions, emphasizing their long-term stability, yet have limited regenerative capacity following cardiac injuries. Dysfunction in these cells can result in significant cardiac issues, including heart failure.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_2000046 "2014-08-12T20:50:28Z"^^xsd:dateTime)
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_2000046 "https://cellxgene.cziscience.com/cellguide/CL_2000046")
AnnotationAssertion(oboInOwl:id obo:CL_2000046 "CL:2000046")
AnnotationAssertion(oboInOwl:inSubset obo:CL_2000046 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_2000046 "ventricular cardiac muscle cell")
@@ -35703,6 +36486,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:TermGenie") obo:IAO_00001
AnnotationAssertion(terms:contributor obo:CL_2000047 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_2000047 "2014-10-02T23:52:53Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:id obo:CL_2000047 "CL:2000047")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_2000047 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_2000047 "brainstem motor neuron")
EquivalentClasses(obo:CL_2000047 ObjectIntersectionOf(obo:CL_0000100 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002298)))
SubClassOf(obo:CL_2000047 obo:CL_0000100)
@@ -35720,9 +36504,9 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_2000048 "ventral horn of spi
AnnotationAssertion(oboInOwl:id obo:CL_2000048 "CL:2000048")
AnnotationAssertion(rdfs:comment obo:CL_2000048 "Yang & Connolly (DOI:10.1016/B978-0-323-37101-8.00140-5) classify these as alpha motor neurons. Consider reflecting this if more references support this.")
AnnotationAssertion(rdfs:label obo:CL_2000048 "anterior horn motor neuron")
+SubClassOf(obo:CL_2000048 obo:CL_0002612)
SubClassOf(obo:CL_2000048 obo:CL_0008039)
SubClassOf(obo:CL_2000048 obo:CL_0011001)
-SubClassOf(obo:CL_2000048 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002257))
# Class: obo:CL_2000049 (primary motor cortex pyramidal cell)
@@ -35788,11 +36572,11 @@ SubClassOf(obo:CL_2000053 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000210
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:dos") Annotation(oboInOwl:hasDbXref "PMID:9408963") obo:IAO_0000115 obo:CL_2000054 "A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid.")
AnnotationAssertion(obo:RO_0002175 obo:CL_2000054 obo:NCBITaxon_9606)
+AnnotationAssertion(oboInOwl:inSubset obo:CL_2000054 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_2000054 core:human_reference_atlas)
AnnotationAssertion(rdfs:comment obo:CL_2000054 "Pit cells are named for the presence of large cytoplasmic granules that resemble pits (pips) of fruit.")
AnnotationAssertion(rdfs:label obo:CL_2000054 "hepatic pit cell")
-SubClassOf(obo:CL_2000054 obo:CL_0000623)
-SubClassOf(obo:CL_2000054 ObjectSomeValuesFrom(obo:RO_0001025 obo:UBERON_0001281))
+SubClassOf(obo:CL_2000054 obo:CL_4047101)
# Class: obo:CL_2000055 (liver dendritic cell)
@@ -35859,9 +36643,15 @@ SubClassOf(obo:CL_2000059 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000236
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31049600") obo:IAO_0000115 obo:CL_2000060 "A trophoblast of placental villi. These cells fuse to form synctial trophoplast - the placental side of the interface between the placenta and maternal blood sinusoids in the decidua.")
AnnotationAssertion(terms:contributor obo:CL_2000060 )
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1007/s00018-019-03104-6") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fimmu.2020.00343") Annotation(oboInOwl:hasDbXref "DOI:10.3390/nu15163564") terms:description obo:CL_2000060 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
+
+The placental villous trophoblast, a highly specialized cell type crucial for placental development, plays a key role in facilitating exchanges between the maternal bloodstream and the developing fetus.
+Structurally, placental villous trophoblasts are situated on the villous tree structures, forming an outer epithelial layer. Comprising two subtypes—proliferating cytotrophoblasts forming the inner layer and terminally differentiated syncytiotrophoblasts constituting the outer layer in contact with maternal blood—these cells define the placental architecture.
+Functionally, placental villous trophoblasts play pivotal roles in forming and maintaining the placenta, ensuring the safe development of the fetus. Their primary function involves managing substance exchange between the mother and fetus, mediating the transfer of gases, nutrients, hormones, and waste materials to support optimal fetal growth. Additionally, these trophoblasts synthesize and release crucial hormones like human chorionic gonadotropin (hCG), which maintains the decidua and signals the mother's body to sustain pregnancy. Acting as a physical and immunological barrier, they protect the fetus from maternal immune cells and prevent the transmission of pathogens, contributing significantly to the success of pregnancy.")
AnnotationAssertion(oboInOwl:creation_date obo:CL_2000060 "2014-10-07T17:48:27Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_2000060 "BTO:0006119")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_2000060 "BTO:0006208")
+AnnotationAssertion(oboInOwl:hasDbXref obo:CL_2000060 "https://cellxgene.cziscience.com/cellguide/CL_2000060")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31049600") oboInOwl:hasExactSynonym obo:CL_2000060 "vCTB")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_2000060 "villous cytotrophoblast")
AnnotationAssertion(oboInOwl:id obo:CL_2000060 "CL:2000060")
@@ -35911,7 +36701,7 @@ AnnotationAssertion(rdfs:comment obo:CL_2000063 "http://www.sciencellonline.com/
AnnotationAssertion(rdfs:label obo:CL_2000063 "ovarian fibroblast")
EquivalentClasses(obo:CL_2000063 ObjectIntersectionOf(obo:CL_0000057 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000992)))
SubClassOf(obo:CL_2000063 obo:CL_0000057)
-SubClassOf(obo:CL_2000063 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000992))
+SubClassOf(obo:CL_2000063 obo:CL_0002132)
# Class: obo:CL_2000064 (ovarian surface epithelial cell)
@@ -36160,6 +36950,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:TermGenie") obo:IAO_00001
AnnotationAssertion(terms:contributor obo:CL_2000084 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_2000084 "2014-12-02T19:28:38Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:id obo:CL_2000084 "CL:2000084")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_2000084 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_2000084 "conjunctiva goblet cell")
EquivalentClasses(obo:CL_2000084 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001811)))
SubClassOf(obo:CL_2000084 obo:CL_0000160)
@@ -36238,7 +37029,6 @@ AnnotationAssertion(oboInOwl:id obo:CL_2000090 "CL:2000090")
AnnotationAssertion(rdfs:label obo:CL_2000090 "dentate gyrus of hippocampal formation stellate cell")
EquivalentClasses(obo:CL_2000090 ObjectIntersectionOf(obo:CL_0000122 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0001885)))
SubClassOf(obo:CL_2000090 obo:CL_0000122)
-SubClassOf(obo:CL_2000090 obo:CL_0012001)
SubClassOf(obo:CL_2000090 obo:CL_4023062)
# Class: obo:CL_2000091 (endometrial microvascular endothelial cell)
@@ -36334,26 +37124,23 @@ AnnotationAssertion(terms:contributor obo:CL_3000000 )
AnnotationAssertion(terms:contributor obo:CL_3000001 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_3000001 "2019-02-18T19:41:20Z"^^xsd:dateTime)
-AnnotationAssertion(Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_3000001 "HBC")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:39007150") oboInOwl:hasExactSynonym obo:CL_3000001 "fetal Hofbauer cell")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:39007150") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_3000001 "HBC")
AnnotationAssertion(oboInOwl:id obo:CL_3000001 "CL:3000001")
AnnotationAssertion(oboInOwl:inSubset obo:CL_3000001 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_3000001 core:human_reference_atlas)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30498493") rdfs:comment obo:CL_3000001 "Hofbauer cells are a heterogenic group of macrophages that resemble M2-like cells. Initially described in chorionic villi in humans, a Hofbauer cell is now often used to describe any fetal-derived placental macrophage that resides within the placental villous core, amnion, and chorion laeve.")
AnnotationAssertion(rdfs:label obo:CL_3000001 "Hofbauer cell")
-SubClassOf(obo:CL_3000001 obo:CL_0000864)
-SubClassOf(obo:CL_3000001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001987))
+SubClassOf(obo:CL_3000001 obo:CL_4033087)
# Class: obo:CL_3000002 (sympathetic noradrenergic neuron)
@@ -36381,10 +37168,11 @@ SubClassOf(obo:CL_3000003 obo:CL_0011103)
# Class: obo:CL_3000004 (peripheral sensory neuron)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:CellBLAST") Annotation(oboInOwl:hasDbXref "PMID:30096314") obo:IAO_0000115 obo:CL_3000004 "Peripheral sensory neuron.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:CellBLAST") Annotation(oboInOwl:hasDbXref "PMID:30096314") Annotation(oboInOwl:hasDbXref "PMID:31554486") Annotation(oboInOwl:hasDbXref "PMID:35858549") Annotation(oboInOwl:hasDbXref "Wikipedia:Sensory_neuron") Annotation(oboInOwl:hasDbXref "https://www.britannica.com/science/sensory-neuron") Annotation(oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK539846/") obo:IAO_0000115 obo:CL_3000004 "A neuron type that is located in a peripheral nervous system and it transmits sensory information from the peripheral (PNS) to the central nervous system (CNS). A sensory neuron converts physical (light, sound, touch) or chemical (such as taste and smell) stimuli into an electrical signal through a process known as sensory transduction. The function of a sensory neuron is to carry informations from the external environment and internal body conditions to the central nervous system for further processing.")
AnnotationAssertion(terms:contributor obo:CL_3000004 )
AnnotationAssertion(oboInOwl:creation_date obo:CL_3000004 "2019-02-25T19:34:33Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:id obo:CL_3000004 "CL:3000004")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "Wikipedia:Sensory_neuron") rdfs:comment obo:CL_3000004 "Typically, a sensory neuron has a pseudounipolar morphology.")
AnnotationAssertion(rdfs:label obo:CL_3000004 "peripheral sensory neuron")
EquivalentClasses(obo:CL_3000004 ObjectIntersectionOf(obo:CL_2000032 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050906)))
SubClassOf(obo:CL_3000004 obo:CL_0000101)
@@ -36530,14 +37318,17 @@ SubClassOf(obo:CL_4023010 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000005460))
AnnotationAssertion(obo:IAO_0000028 obo:CL_4023011 "Lamp5 cortical interneuron")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30382198") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/") obo:IAO_0000115 obo:CL_4023011 "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Lamp5.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4023011 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4023011 )
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_4023011 "ILX:0770149")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023011 cl:BDS_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023011 cl:cellxgene_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4023011 "The marker set LINC00298, KIT can identify the Human cell type lamp5 GABAergic cortical interneuron in the Brain with a confidence of 0.814687838 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4023011 "lamp5 GABAergic cortical interneuron")
EquivalentClasses(obo:CL_4023011 ObjectIntersectionOf(obo:CL_0000099 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000956) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061534) ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000032148)))
SubClassOf(obo:CL_4023011 obo:CL_4023064)
SubClassOf(obo:CL_4023011 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000032148))
+SubClassOf(obo:CL_4023011 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000074))
# Class: obo:CL_4023012 (near-projecting glutamatergic cortical neuron)
@@ -36589,19 +37380,23 @@ SubClassOf(obo:CL_4023014 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_P32648))
AnnotationAssertion(obo:IAO_0000028 obo:CL_4023015 "sncg cortical interneuron")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33186530") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/") obo:IAO_0000115 obo:CL_4023015 "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Gamma-synuclein. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sncg.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4023015 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4023015 )
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_4023015 "ILX:0770150")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023015 cl:BDS_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023015 cl:cellxgene_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4023015 "The marker set RXRG, THSD7B can identify the Human cell type sncg GABAergic cortical interneuron in the Brain with a confidence of 0.628943702 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4023015 "sncg GABAergic cortical interneuron")
EquivalentClasses(obo:CL_4023015 ObjectIntersectionOf(obo:CL_0000099 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000956) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061534) ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000015325)))
SubClassOf(obo:CL_4023015 obo:CL_4023064)
SubClassOf(obo:CL_4023015 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000015325))
+SubClassOf(obo:CL_4023015 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000081))
# Class: obo:CL_4023016 (VIP GABAergic cortical interneuron)
AnnotationAssertion(obo:IAO_0000028 obo:CL_4023016 "VIP cortical interneuron")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33186530") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/") obo:IAO_0000115 obo:CL_4023016 "A transcriptomically distinct cortical GABAergic neuron that expresses the vasocactive intestinal polypeptide and that has its soma located in the cerebral cortex. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Vip.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4023016 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4023016 )
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:26420784") Annotation(oboInOwl:hasDbXref "PMID:31210267") Annotation(oboInOwl:hasDbXref "PMID:33794534") Annotation(oboInOwl:hasDbXref "PMID:35221922") terms:description obo:CL_4023016 "This neuronal type is distinguished by its heterogeneous morphology and electrophysiological characteristics (Pronneke et al., 2015,2020; Apicella and Marchionni, 2022). Variations in morphology and firing patterns are observed in human cortical VIP interneurons. In a study by Lee et al., 2023, four distinct subtypes of VIP neurons were identified, each exhibiting unique morphologies, soma locations, and electrophysiological properties. These subtypes are defined according to their transcriptomic markers: LBH-VIP and CCD184-VIP, both of which display a bipolar morphology with axons and dendrites extending across cortical layers; and SY16-VIP and ADAMTSL1-VIP, characterized by a dendritic arbor that spreads horizontally within the same layer as the soma (Lee et al., 2023). Disruption or malfunction of VIP cortical interneuron is implicated in neurodevelopmental disorders such as Rett Syndrome and Dravet Syndrome (Goff and Goldberg 2021).")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33108272") oboInOwl:hasBroadSynonym obo:CL_4023016 "VIP interneuron")
@@ -36615,15 +37410,18 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "ILX:0770151") oboInOwl:hasRel
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:36384143") oboInOwl:hasRelatedSynonym obo:CL_4023016 "cortical VIP neuron")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023016 cl:BDS_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023016 cl:cellxgene_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4023016 "The marker set VIP can identify the Human cell type VIP GABAergic cortical interneuron in the Brain with a confidence of 0.855531344 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4023016 "VIP GABAergic cortical interneuron")
EquivalentClasses(obo:CL_4023016 ObjectIntersectionOf(obo:CL_0000099 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000956) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061534) ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000017299)))
SubClassOf(obo:CL_4023016 obo:CL_4023064)
SubClassOf(obo:CL_4023016 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000017299))
+SubClassOf(obo:CL_4023016 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000085))
# Class: obo:CL_4023017 (sst GABAergic cortical interneuron)
AnnotationAssertion(obo:IAO_0000028 obo:CL_4023017 "sst cortical interneuron")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:27477017") Annotation(oboInOwl:hasDbXref "PMID:33742131") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/") obo:IAO_0000115 obo:CL_4023017 "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst). The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Sst.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4023017 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4023017 )
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_4023017 "ILX:0770152")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30001424") oboInOwl:hasRelatedSynonym obo:CL_4023017 "SOM+ inhibitory interneuron")
@@ -36632,23 +37430,28 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30001424") oboInOwl:hasR
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023017 cl:BDS_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023017 cl:cellxgene_subset)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:28821651") Annotation(oboInOwl:hasDbXref "PMID:30792151") Annotation(oboInOwl:hasDbXref "PMID:32494634") Annotation(oboInOwl:hasDbXref "PMID:33742131") rdfs:comment obo:CL_4023017 "In the mouse cortex, sst GABAergic cortical interneurons show heterogeneous electrophysiological signatures varying between low-threshold spiking (LTS), regular-spiking and fast-spiking (Song, Y. H., Yoon, J., & Lee, S. H. 2021). Sst GABAergic cortical interneurons have multiple functional roles in the brain. In the mouse, they involved in the generation of slow-waves during the sleep phase of non-rapid eye-movement (NREM) (Funk, C. M. et al., 2017), they maintain synaptic plasticity during motor learning (Adler, A., Zhao, R., et al., 2021), they enhance visual perception in the V1 cortical area by suppressing the activity of pyramidal excitatory neurons (Song, YH. et al., 2020). In humans, malfunctioning of sst GABAergic cortical interneurons is associated with neurodegenerative and psychiatric disorders such as Parkinson's disease, Alzheimer's disease, major depressive disorder, bipolar disorder and schizophrenia as individuals affected by these pathologies show a decrease of expression of SST in the brain (Song YH., Yoon J. et al., 2021).")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4023017 "The marker set SST, PLCH1 can identify the Human cell type sst GABAergic cortical interneuron in the Brain with a confidence of 0.842367005 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4023017 "sst GABAergic cortical interneuron")
EquivalentClasses(obo:CL_4023017 ObjectIntersectionOf(obo:CL_4023069 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000956) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061534) ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000015665)))
SubClassOf(obo:CL_4023017 obo:CL_4023069)
SubClassOf(obo:CL_4023017 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000015665))
+SubClassOf(obo:CL_4023017 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000082))
# Class: obo:CL_4023018 (pvalb GABAergic cortical interneuron)
AnnotationAssertion(obo:IAO_0000028 obo:CL_4023018 "pvalb cortical interneuron")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:27477017") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/") obo:IAO_0000115 obo:CL_4023018 "A transcriptomically distinct GABAergic interneuron with a soma located in a cerebral cortex and it expresses Parvalbumin. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Pvalb.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4023018 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4023018 )
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_4023018 "ILX:0770154")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023018 cl:BDS_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023018 cl:cellxgene_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4023018 "The marker set PVALB, TAC1, MYO5B can identify the Human cell type pvalb GABAergic cortical interneuron in the Brain with a confidence of 0.691998764 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4023018 "pvalb GABAergic cortical interneuron")
EquivalentClasses(obo:CL_4023018 ObjectIntersectionOf(obo:CL_4023069 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000956) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061534) ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000013502)))
SubClassOf(obo:CL_4023018 obo:CL_4023069)
SubClassOf(obo:CL_4023018 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000013502))
+SubClassOf(obo:CL_4023018 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000080))
# Class: obo:CL_4023019 (L5/6 cck, VIP GABAergic interneuron (Mmus))
@@ -36733,6 +37536,7 @@ AnnotationAssertion(terms:contributor obo:CL_4023026 )
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_4023036 "ILX:0107356")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4023036 "Chandelier PV")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023036 cl:BDS_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023036 cl:cellxgene_subset)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:27477017") rdfs:comment obo:CL_4023036 "In mice, Chandelier PV cells have soma found in in upper L2/3, with some in deep L5 and exhibit fast-spiking but lower firing rate compared to basket cells, and have practically absent hyperpolarization sag.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4023036 "The marker set GPR149, CA8 can identify the Human cell type chandelier pvalb GABAergic cortical interneuron in the Brain with a confidence of 0.799748111 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4023036 "chandelier pvalb GABAergic cortical interneuron")
SubClassOf(obo:CL_4023036 obo:CL_4023018)
SubClassOf(obo:CL_4023036 obo:CL_4023083)
+SubClassOf(obo:CL_4023036 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000063))
# Class: obo:CL_4023038 (L6b glutamatergic cortical neuron)
@@ -36888,7 +37696,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898
AnnotationAssertion(rdfs:label obo:CL_4023039 "amygdala excitatory neuron")
EquivalentClasses(obo:CL_4023039 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0001876) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061535)))
SubClassOf(obo:CL_4023039 obo:CL_0000679)
-SubClassOf(obo:CL_4023039 obo:CL_2000029)
+SubClassOf(obo:CL_4023039 obo:CL_0012001)
SubClassOf(obo:CL_4023039 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0001876))
# Class: obo:CL_4023040 (L2/3-6 intratelencephalic projecting glutamatergic neuron)
@@ -36906,6 +37714,7 @@ SubClassOf(obo:CL_4023040 obo:CL_4023008)
AnnotationAssertion(obo:IAO_0000028 obo:CL_4023041 "L5 ET glut")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34616075") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/") obo:IAO_0000115 obo:CL_4023041 "A transcriptomically distinct glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons ', Author Categories: 'CrossArea_subclass', clusters L5 ET.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4023041 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4023041 )
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.neuron.2005.08.030") oboInOwl:hasBroadSynonym obo:CL_4023041 "subcerebral projection (SCPN) neuron")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31626774") Annotation(rdfs:comment "pyramidal tract-like is used because, unlike pyramidal tract neurons in the motor cortex, neurons in the structures like the auditory cortex do not project to the spinal cord.") oboInOwl:hasExactSynonym obo:CL_4023041 "Pyramidal tract-like (PT-l)")
@@ -36915,25 +37724,30 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1038/nrn3469") oboInOw
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1016/j.neuron.2011.07.029") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4023041 "L5b neuron")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023041 cl:BDS_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023041 cl:cellxgene_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4023041 "The marker set CHST8, POU3F1 can identify the Human cell type L5 extratelencephalic projecting glutamatergic cortical neuron in the Brain with a confidence of 0.815891473 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4023041 "L5 extratelencephalic projecting glutamatergic cortical neuron")
EquivalentClasses(obo:CL_4023041 ObjectIntersectionOf(obo:CL_4023009 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005394)))
SubClassOf(obo:CL_4023041 obo:CL_4023009)
SubClassOf(obo:CL_4023041 obo:CL_4023111)
SubClassOf(obo:CL_4023041 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005394))
+SubClassOf(obo:CL_4023041 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000067))
# Class: obo:CL_4023042 (L6 corticothalamic-projecting glutamatergic cortical neuron)
AnnotationAssertion(obo:IAO_0000028 obo:CL_4023042 "L6 CT glut")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34616075") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/") obo:IAO_0000115 obo:CL_4023042 "A transcriptomically distinct corticothalamic-projecting neuron with a soma found in cortical layer 6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L6 CT.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4023042 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4023042 )
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:28625486") Annotation(oboInOwl:hasDbXref "PMID:34616075") oboInOwl:hasExactSynonym obo:CL_4023042 "L6 CT")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023042 cl:BDS_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023042 cl:cellxgene_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4023042 "The marker set SEMA5B, ADAMTSL1, SULF1 can identify the Human cell type L6 corticothalamic-projecting glutamatergic cortical neuron in the Brain with a confidence of 0.631898455 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4023042 "L6 corticothalamic-projecting glutamatergic cortical neuron")
EquivalentClasses(obo:CL_4023042 ObjectIntersectionOf(obo:CL_4023013 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005395)))
SubClassOf(obo:CL_4023042 obo:CL_4023013)
SubClassOf(obo:CL_4023042 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005395))
SubClassOf(obo:CL_4023042 ObjectSomeValuesFrom(obo:RO_0013001 obo:UBERON_0010225))
+SubClassOf(obo:CL_4023042 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000070))
# Class: obo:CL_4023043 (L5/6 near-projecting glutamatergic neuron of the primary motor cortex)
@@ -36981,12 +37795,15 @@ SubClassOf(obo:CL_4023045 ObjectSomeValuesFrom(obo:RO_0013001 obo:UBERON_0001896
AnnotationAssertion(obo:IAO_0000028 obo:CL_4023046 "L6b subplate glut")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33184512") obo:IAO_0000115 obo:CL_4023046 "An excitatory glutamatergic neuron transcriptomically related to the CT subclass, with a soma preferentially located in the bottom of L6 of the primary motor cortex.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4023046 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4023046 )
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4023046 "L6b subplate glutamatergic neuron of the primary motor cortex")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023046 cl:BDS_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4023046 "The marker set CCN2, ROS1 can identify the Human cell type L6b glutamatergic neuron of the primary motor cortex in the Brain with a confidence of 0.819940964 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4023046 "L6b glutamatergic neuron of the primary motor cortex")
SubClassOf(obo:CL_4023046 obo:CL_4023038)
SubClassOf(obo:CL_4023046 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0001384))
+SubClassOf(obo:CL_4023046 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000073))
# Class: obo:CL_4023047 (L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex)
@@ -37044,8 +37861,8 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_4023050 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_4023050 "L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex")
EquivalentClasses(obo:CL_4023050 ObjectIntersectionOf(obo:CL_4030065 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0001384)))
SubClassOf(obo:CL_4023050 obo:CL_2000049)
+SubClassOf(obo:CL_4023050 obo:CL_4023095)
SubClassOf(obo:CL_4023050 obo:CL_4030065)
-SubClassOf(obo:CL_4023050 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070019))
# Class: obo:CL_4023051 (vascular leptomeningeal cell)
@@ -37099,7 +37916,7 @@ AnnotationAssertion(rdfs:comment obo:CL_4023055 "The assertion of this cell type
AnnotationAssertion(rdfs:label obo:CL_4023055 "corticothalamic VAL/VM projecting glutamatergic neuron of the primary motor cortex")
SubClassOf(obo:CL_4023055 obo:CL_2000049)
SubClassOf(obo:CL_4023055 obo:CL_4023042)
-SubClassOf(obo:CL_4023055 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070019))
+SubClassOf(obo:CL_4023055 obo:CL_4023095)
# Class: obo:CL_4023056 (vascular leptomeningeal cell (Mmus))
@@ -37124,7 +37941,6 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_4023057 core:human_reference_atlas)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898") rdfs:comment obo:CL_4023057 "A GABAergic interneuron whose soma is located in the cerebellar cortex.")
AnnotationAssertion(rdfs:label obo:CL_4023057 "cerebellar inhibitory GABAergic interneuron")
EquivalentClasses(obo:CL_4023057 ObjectIntersectionOf(obo:CL_0011005 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002129)))
-SubClassOf(obo:CL_4023057 obo:CL_0000402)
SubClassOf(obo:CL_4023057 obo:CL_0011005)
SubClassOf(obo:CL_4023057 obo:CL_1001611)
SubClassOf(obo:CL_4023057 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002129))
@@ -37171,7 +37987,7 @@ AnnotationAssertion(obo:RO_0002175 obo:CL_4023061 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4023061 )
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023061 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_4023061 "hippocampal CA4 neuron")
-SubClassOf(obo:CL_4023061 obo:CL_0000540)
+SubClassOf(obo:CL_4023061 obo:CL_2000029)
# Class: obo:CL_4023062 (dentate gyrus neuron)
@@ -37213,9 +38029,8 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20130169") Annotation(ob
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023064 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_4023064 "caudal ganglionic eminence derived cortical interneuron")
EquivalentClasses(obo:CL_4023064 ObjectIntersectionOf(obo:CL_0000099 ObjectSomeValuesFrom(obo:RO_0002202 obo:UBERON_0004026)))
-SubClassOf(obo:CL_4023064 obo:BFO_0000002)
SubClassOf(obo:CL_4023064 obo:CL_0010011)
-SubClassOf(obo:CL_4023064 ObjectSomeValuesFrom(obo:RO_0002202 obo:UBERON_0004026))
+SubClassOf(obo:CL_4023064 obo:CL_4042039)
# Class: obo:CL_4023065 (meis2 expressing cortical GABAergic cell)
@@ -37236,8 +38051,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30715238") obo:IAO_00001
AnnotationAssertion(terms:contributor obo:CL_4023066 )
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023066 cl:BDS_subset)
AnnotationAssertion(rdfs:label obo:CL_4023066 "horizontal pyramidal neuron")
-EquivalentClasses(obo:CL_4023066 ObjectIntersectionOf(obo:CL_0000117 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070016)))
-SubClassOf(obo:CL_4023066 obo:CL_0000117)
+EquivalentClasses(obo:CL_4023066 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070016)))
SubClassOf(obo:CL_4023066 obo:CL_0000598)
SubClassOf(obo:CL_4023066 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070016))
@@ -37254,14 +38068,16 @@ AnnotationAssertion(owl:deprecated obo:CL_4023067 "true"^^xsd:boolean)
# Class: obo:CL_4023068 (thalamic excitatory neuron)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898") obo:IAO_0000115 obo:CL_4023068 "An excitatory neuron that has its soma located in the thalamic complex.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30083593") Annotation(oboInOwl:hasDbXref "PMID:31196673") Annotation(oboInOwl:hasDbXref "PMID:35278647") Annotation(oboInOwl:hasDbXref "PMID:37163009") Annotation(oboInOwl:hasDbXref "PMID:37824663") Annotation(oboInOwl:hasDbXref "PMID:38739251") obo:IAO_0000115 obo:CL_4023068 "An excitatory neuron that has its soma located in the thalamic complex. This neuron type can be involved in a series of circuits related to sensory integration, motor integration, pain processing, social behaviour and reward response.")
AnnotationAssertion(obo:RO_0002175 obo:CL_4023068 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4023068 )
+AnnotationAssertion(oboInOwl:inSubset obo:CL_4023068 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023068 core:human_reference_atlas)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:11532718") Annotation(oboInOwl:hasDbXref "PMID:30083593") Annotation(oboInOwl:hasDbXref "PMID:38739251") rdfs:comment obo:CL_4023068 "Abnormalities in glutametergic neurons of the thalamic complex are associated with pathologies such as schizophrenia, colorectal visceral pain and Parkinson's disease.")
AnnotationAssertion(rdfs:label obo:CL_4023068 "thalamic excitatory neuron")
EquivalentClasses(obo:CL_4023068 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0010225) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061535)))
SubClassOf(obo:CL_4023068 obo:CL_0000679)
-SubClassOf(obo:CL_4023068 obo:CL_2000029)
+SubClassOf(obo:CL_4023068 obo:CL_0012001)
SubClassOf(obo:CL_4023068 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0010225))
# Class: obo:CL_4023069 (medial ganglionic eminence derived GABAergic cortical interneuron)
@@ -37311,6 +38127,7 @@ SubClassOf(obo:CL_4023071 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_P09240))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898") obo:IAO_0000115 obo:CL_4023072 "A cell that is part of the brain vasculature.")
AnnotationAssertion(obo:RO_0002175 obo:CL_4023072 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4023072 )
+AnnotationAssertion(oboInOwl:inSubset obo:CL_4023072 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023072 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_4023072 "brain vascular cell")
EquivalentClasses(obo:CL_4023072 ObjectIntersectionOf(obo:CL_0000000 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008998)))
@@ -37334,7 +38151,7 @@ AnnotationAssertion(terms:contributor obo:CL_4023074 )
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023092 cl:BDS_subset)
AnnotationAssertion(rdfs:label obo:CL_4023092 "inverted pyramidal neuron")
-EquivalentClasses(obo:CL_4023092 ObjectIntersectionOf(obo:CL_0000117 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070021)))
-SubClassOf(obo:CL_4023092 obo:CL_0000117)
+EquivalentClasses(obo:CL_4023092 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070021)))
SubClassOf(obo:CL_4023092 obo:CL_0000598)
SubClassOf(obo:CL_4023092 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070021))
@@ -37504,8 +38320,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30715238") obo:IAO_00001
AnnotationAssertion(terms:contributor obo:CL_4023093 )
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023093 cl:BDS_subset)
AnnotationAssertion(rdfs:label obo:CL_4023093 "stellate pyramidal neuron")
-EquivalentClasses(obo:CL_4023093 ObjectIntersectionOf(obo:CL_0000117 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070020)))
-SubClassOf(obo:CL_4023093 obo:CL_0000117)
+EquivalentClasses(obo:CL_4023093 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070020)))
SubClassOf(obo:CL_4023093 obo:CL_0000598)
SubClassOf(obo:CL_4023093 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070020))
@@ -37515,8 +38330,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30715238") obo:IAO_00001
AnnotationAssertion(terms:contributor obo:CL_4023094 )
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023094 cl:BDS_subset)
AnnotationAssertion(rdfs:label obo:CL_4023094 "tufted pyramidal neuron")
-EquivalentClasses(obo:CL_4023094 ObjectIntersectionOf(obo:CL_0000117 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070018)))
-SubClassOf(obo:CL_4023094 obo:CL_0000117)
+EquivalentClasses(obo:CL_4023094 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070018)))
SubClassOf(obo:CL_4023094 obo:CL_0000598)
SubClassOf(obo:CL_4023094 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070018))
@@ -37526,8 +38340,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30715238") obo:IAO_00001
AnnotationAssertion(terms:contributor obo:CL_4023095 )
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023095 cl:BDS_subset)
AnnotationAssertion(rdfs:label obo:CL_4023095 "untufted pyramidal neuron")
-EquivalentClasses(obo:CL_4023095 ObjectIntersectionOf(obo:CL_0000117 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070019)))
-SubClassOf(obo:CL_4023095 obo:CL_0000117)
+EquivalentClasses(obo:CL_4023095 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070019)))
SubClassOf(obo:CL_4023095 obo:CL_0000598)
SubClassOf(obo:CL_4023095 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070019))
@@ -37675,7 +38488,7 @@ AnnotationAssertion(terms:contributor obo:CL_4023110 )
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_4023120 "FMA:62364")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4023120 "cochlear hair cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_4023120 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_4023120 "cochlea auditory hair cell")
EquivalentClasses(obo:CL_4023120 ObjectIntersectionOf(obo:CL_0000202 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002227)))
SubClassOf(obo:CL_4023120 obo:BFO_0000002)
@@ -37783,12 +38597,15 @@ SubClassOf(obo:CL_4023120 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000222
AnnotationAssertion(obo:IAO_0000028 obo:CL_4023121 "sst chodl cortical interneuron")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:15845086") Annotation(oboInOwl:hasDbXref "PMID:31209381") Annotation(oboInOwl:hasDbXref "PMID:33372656") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/") obo:IAO_0000115 obo:CL_4023121 "A transcriptomically distinct sst GABAergic cortical interneuron that also expresses Chodl. These neurons are rare and correspond to the only known cortical interneurons with long-range projection. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sst Chodl.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4023121 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4023121 )
AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_4023121 "long-range GABAergic interneuron")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023121 cl:cellxgene_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4023121 "The marker set NPY can identify the Human cell type sst chodl GABAergic cortical interneuron in the Brain with a confidence of 0.894026187 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4023121 "sst chodl GABAergic cortical interneuron")
SubClassOf(obo:CL_4023121 obo:CL_4023017)
SubClassOf(obo:CL_4023121 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000005444))
+SubClassOf(obo:CL_4023121 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000083))
# Class: obo:CL_4023122 (oxytocin receptor sst GABAergic cortical interneuron)
@@ -37810,7 +38627,7 @@ AnnotationAssertion(terms:contributor obo:CL_4023123 )
AnnotationAssertion(rdfs:label obo:CL_4023123 "hypothalamus kisspeptin neuron")
EquivalentClasses(obo:CL_4023123 ObjectIntersectionOf(obo:CL_4023130 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0001898)))
-SubClassOf(obo:CL_4023123 obo:CL_2000029)
+SubClassOf(obo:CL_4023123 obo:CL_0012001)
SubClassOf(obo:CL_4023123 obo:CL_4023130)
SubClassOf(obo:CL_4023123 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0001898))
@@ -37879,7 +38696,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30042117") rdfs:comment
AnnotationAssertion(rdfs:label obo:CL_4023130 "kisspeptin neuron")
EquivalentClasses(obo:CL_4023130 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000009344)))
SubClassOf(obo:CL_4023130 obo:BFO_0000002)
-SubClassOf(obo:CL_4023130 obo:CL_0000540)
+SubClassOf(obo:CL_4023130 obo:CL_2000029)
SubClassOf(obo:CL_4023130 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000009344))
# Class: obo:CL_4023154 (myelinating glial cell)
@@ -37928,8 +38745,9 @@ SubClassOf(obo:CL_4023160 ObjectSomeValuesFrom(obo:RO_0002103 obo:CL_0000120))
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:9193142") Annotation(oboInOwl:hasDbXref "WikipediaVersioned:Unipolar_brush_cell&oldid=1045937026") obo:IAO_0000115 obo:CL_4023161 "An excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granule cell domain of the cochlear nucleus. Unipolar brush cells have a round or oval cell body with usually a single short dendrite that ends in a brush-like tuft of short dendrites unique to them known as dendrioles.")
AnnotationAssertion(terms:contributor obo:CL_4023161 )
+AnnotationAssertion(oboInOwl:inSubset obo:CL_4023161 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_4023161 "unipolar brush cell")
-SubClassOf(obo:CL_4023161 obo:CL_0000402)
+SubClassOf(obo:CL_4023161 obo:CL_0000099)
SubClassOf(obo:CL_4023161 obo:CL_0000679)
SubClassOf(obo:CL_4023161 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070025))
SubClassOf(obo:CL_4023161 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0002028))
@@ -37964,8 +38782,8 @@ SubClassOf(obo:CL_4023164 obo:CL_4023162)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:22865660") obo:IAO_0000115 obo:CL_4023168 "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli.")
AnnotationAssertion(terms:contributor obo:CL_4023168 )
AnnotationAssertion(rdfs:label obo:CL_4023168 "somatosensory neuron")
-EquivalentClasses(obo:CL_4023168 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003942)))
-SubClassOf(obo:CL_4023168 obo:CL_0000540)
+EquivalentClasses(obo:CL_4023168 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003942) ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000010)))
+SubClassOf(obo:CL_4023168 obo:CL_2000032)
SubClassOf(obo:CL_4023168 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003942))
# Class: obo:CL_4023169 (trigeminal neuron)
@@ -37973,7 +38791,7 @@ SubClassOf(obo:CL_4023168 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000394
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:22190641") Annotation(oboInOwl:hasDbXref "WikipediaVersioned:Trigeminal_nerve&oldid=1099897926") obo:IAO_0000115 obo:CL_4023169 "A neuron that is responsible for sensation in the face or motor functions such as biting and chewing. Trigeminal neurons extend a single axon shaft along the lateral white matter of the hindbrain and spinal cord. The highly branched axons innervate the integument of the head.")
AnnotationAssertion(terms:contributor obo:CL_4023169 )
AnnotationAssertion(rdfs:label obo:CL_4023169 "trigeminal neuron")
-SubClassOf(obo:CL_4023169 obo:CL_0000540)
+SubClassOf(obo:CL_4023169 obo:CL_2000029)
# Class: obo:CL_4023170 (trigeminal sensory neuron)
@@ -37982,8 +38800,8 @@ AnnotationAssertion(terms:contributor obo:CL_4023170 ) Annotation(oboInOwl:hasDbXref "PMID:26778959") Annotation(oboInOwl:hasDbXref "PMID:9579598") obo:IAO_0000115 obo:CL_4023181 "A neurecto-epithelial cell that is part of the basal layer of the subcommissural organ and specializes in the secretion of proteins into the subarachnoid space. Hypendymal cells have similar characteristics to ependymal cells and express SCO-spondin.")
AnnotationAssertion(terms:contributor obo:CL_4023181 )
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/(SICI)1097-0029(19980415)41:2<98::AID-JEMT2>3.0.CO;2-M") Annotation(oboInOwl:hasDbXref "DOI:10.1111/joa.13709") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fncel.2015.00480") terms:description obo:CL_4023181 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional.
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "DOI:10.1002/(SICI)1097-0029(19980415)41:2<98::AID-JEMT2>3.0.CO;2-M") Annotation(oboInOwl:hasDbXref "DOI:10.1111/joa.13709") Annotation(oboInOwl:hasDbXref "DOI:10.3389/fncel.2015.00480") terms:description obo:CL_4023181 "This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.
Hypendymal cells are secretory cells located between the ependymal layer and the posterior commissure, forming the hypendmal layer of the subcommissural organ (SCO), a highly conserved gland that is part of the circumventricular system within the brain.
Hypendymal cells are bipolar cells with a thin apical pole and basal process. Most of the ultrastructural characteristics of these cells are similar to those described for the ependymal cells (which are arranged into another layer – the ependyma). However, ependymal cells release their secretion into the ventricular cerebrospinal fluid whereas hypendymal cells project processes to the local blood vessels and to the subarachnoidal space.")
@@ -38019,7 +38837,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:10845061") oboInOwl:hasE
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:10845061") rdfs:comment obo:CL_4023187 "In adult monkeys, koniocellular cells can be distinguished from parvocellular and magnocellular of the LGN by their expression of calbindin, the alpha subunit of type II calmodulin-dependent protein kinase, and the gamma subunit of protein kinase C.")
AnnotationAssertion(rdfs:label obo:CL_4023187 "koniocellular cell")
EquivalentClasses(obo:CL_4023187 ObjectIntersectionOf(obo:CL_0000540 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0013615)))
-SubClassOf(obo:CL_4023187 obo:CL_2000029)
+SubClassOf(obo:CL_4023187 obo:CL_0012001)
SubClassOf(obo:CL_4023187 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0013615))
# Class: obo:CL_4023188 (midget ganglion cell of retina)
@@ -38028,6 +38846,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:32533915") Annotation(ob
AnnotationAssertion(obo:RO_0002175 obo:CL_4023188 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4023188 "https://orcid.org/0000-0001-7258-9596")
AnnotationAssertion(terms:contributor obo:CL_4023188 "https://orcid.org/0000-0001-7655-4833")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_4023188 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023188 core:human_reference_atlas)
AnnotationAssertion(rdfs:comment obo:CL_4023188 "There are midget bipolar cells of retina and midget ganglion cells of retina and they are not the same:
Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances from the fovea (retinal eccentricity of 4.5mm as compared to 12 mm). Midget ganglion cells (MGC) have larger dendritic fields (here seen at 8 mm) as they increase in eccentricity.")
@@ -38043,6 +38862,7 @@ AnnotationAssertion(terms:contributor obo:CL_4023189 "https://orcid.org/0000-000
AnnotationAssertion(terms:contributor obo:CL_4023189 "https://orcid.org/0000-0001-7655-4833")
AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_4023189 "M cell")
AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_4023189 "M ganglion cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_4023189 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023189 core:human_reference_atlas)
AnnotationAssertion(rdfs:comment obo:CL_4023189 "These cells should not be confused with M1-M14 retinal ganglion cells described in PMID:16626866 which refer to a different classification of retinal ganglion cells.")
AnnotationAssertion(rdfs:label obo:CL_4023189 "parasol ganglion cell of retina")
@@ -38111,10 +38931,12 @@ AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_4028004 "pulmonary lipofibro
AnnotationAssertion(Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4028004 "AF1")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4028004 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4028004 core:human_reference_atlas)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4028004 "The marker set AOC3, LUM can identify the Human cell type alveolar type 1 fibroblast cell in the Lung with a confidence of 0.70 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4028004 "alveolar type 1 fibroblast cell")
SubClassOf(obo:CL_4028004 obo:CL_0002241)
SubClassOf(obo:CL_4028004 obo:CL_0002553)
SubClassOf(obo:CL_4028004 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002299))
+SubClassOf(obo:CL_4028004 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000002))
# Class: obo:CL_4028006 (alveolar adventitial fibroblast)
@@ -38133,10 +38955,12 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33208946") Annotation(ob
AnnotationAssertion(Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4028006 "MANC")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4028006 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4028006 core:human_reference_atlas)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4028006 "The marker set SCARA5, CD248 can identify the Human cell type alveolar adventitial fibroblast in the Lung with a confidence of 0.85 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4028006 "alveolar adventitial fibroblast")
SubClassOf(obo:CL_4028006 obo:CL_0002241)
SubClassOf(obo:CL_4028006 obo:CL_0002553)
SubClassOf(obo:CL_4028006 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002299))
+SubClassOf(obo:CL_4028006 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000001))
# Class: obo:CL_4029001 (gamete-nursing cell)
@@ -38231,7 +39055,7 @@ SubClassOf(obo:CL_4030005 obo:CL_1000715)
# Class: obo:CL_4030006 (fallopian tube secretory epithelial cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.1186/1477-7827-7-129") Annotation(oboInOwl:hasDbXref "https://doi.org/10.3390/cells8080933") Annotation(oboInOwl:hasDbXref "https://www.proteinatlas.org/learn/dictionary/normal/fallopian+tube") obo:IAO_0000115 obo:CL_4030006 "An epithelial cell that is part of the fallopian tube epithelium that secretes mucous fluid and oviduct-specific products through the stimulation of estrogen and luteinizing hormone. The fallopian tube secretory cell has approximately the same height as the ciliated cell and is usually a more narrow columnar cell. The nucleus is ovoid and perpendicular to the long axis of the cell. The chromatin is more dense and the nucleolus smaller than that seen in the ciliated cell.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.1186/1477-7827-7-129") Annotation(oboInOwl:hasDbXref "https://doi.org/10.3390/cells8080933") Annotation(oboInOwl:hasDbXref "https://www.proteinatlas.org/learn/dictionary/normal/fallopian+tube") obo:IAO_0000115 obo:CL_4030006 "An epithelial cell that is part of the fallopian tube that secretes mucus and oviduct-specific products in response to hormonal stimulation from estrogen and luteinizing hormone. This fallopian tube secretory cell is similar in height to the ciliated cell, but typically exhibits a more narrow, columnar shape. Its nucleus is ovoid and oriented perpendicular to the cell's long axis, with denser chromatin and a smaller nucleolus compared to the ciliated cell.")
AnnotationAssertion(obo:RO_0002175 obo:CL_4030006 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4030006 )
AnnotationAssertion(terms:date obo:CL_4030006 "2022-03-03T10:39:31Z"^^xsd:dateTime)
@@ -38241,20 +39065,21 @@ AnnotationAssertion(oboInOwl:inSubset obo:CL_4030006 core:human_reference_atlas)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.1016/j.ccr.2013.10.013") Annotation(oboInOwl:hasDbXref "https://www.proteinatlas.org/learn/dictionary/normal/fallopian+tube") rdfs:comment obo:CL_4030006 "The other cell types of the fallopian tube epithelium include the ciliated cell and the intercalary cell, or peg cell. The fallopian tube secretory epithelial cell type has been implicated as a source of high-grade serous ovarian carcinoma.")
AnnotationAssertion(rdfs:label obo:CL_4030006 "fallopian tube secretory epithelial cell")
SubClassOf(obo:CL_4030006 obo:CL_1001591)
-SubClassOf(obo:CL_4030006 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003889))
+SubClassOf(obo:CL_4030006 obo:CL_4052019)
-# Class: obo:CL_4030007 (fallopian tube ciliated cell)
+# Class: obo:CL_4030007 (fallopian tube multiciliated cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:16565155") obo:IAO_0000115 obo:CL_4030007 "An epithelial ciliated cell that is part of the fallopian tube. This cell type is found mainly on the apex of the mucosal folds and contributes, together with peristaltic contractions, to the self-propulsion of spermatozoa, the transport of ovum during ovulation and the transport of the fertilized ovum to the intramural fallopian tube. A fallopian tube ciliated cell has a columnar shape and contains an oval or round nucleus, often located perpendicular or parallel to the long axis of the cell.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:16565155") Annotation(oboInOwl:hasDbXref "https://www.proteinatlas.org/humanproteome/tissue/fallopian+tube") obo:IAO_0000115 obo:CL_4030007 "A multi-ciliated epithelial cell that is part of the fallopian tube, mainly found on the apex of the mucosal folds. This cell exhibits a columnar shape with an oval nucleus and is characterized by the presence of cilia on its surface. The coordinated beating of these cilia, together with peristaltic contractions, contributes to the self-propulsion of spermatozoa, the transport of ovum during ovulation and the transport of the fertilized ovum to the intramural fallopian tube.")
AnnotationAssertion(obo:RO_0002175 obo:CL_4030007 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4030007 )
AnnotationAssertion(terms:date obo:CL_4030007 "2022-03-08T12:40:19Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_4030007 "oviduct ciliated cell")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030007 "fallopian tube ciliated cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030007 "uterine tube ciliated epithelial cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4030007 core:human_reference_atlas)
-AnnotationAssertion(rdfs:label obo:CL_4030007 "fallopian tube ciliated cell")
+AnnotationAssertion(rdfs:label obo:CL_4030007 "fallopian tube multiciliated cell")
SubClassOf(obo:CL_4030007 obo:CL_0005012)
-SubClassOf(obo:CL_4030007 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003889))
+SubClassOf(obo:CL_4030007 obo:CL_4052018)
SubClassOf(obo:CL_4030007 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0007589))
# Class: obo:CL_4030008 (pronephric podocyte)
@@ -38443,13 +39268,14 @@ EquivalentClasses(obo:CL_4030022 ObjectIntersectionOf(obo:CL_0000057 ObjectSomeV
SubClassOf(obo:CL_4030022 obo:CL_1000682)
SubClassOf(obo:CL_4030022 obo:CL_1000692)
-# Class: obo:CL_4030023 (respiratory hillock cell)
+# Class: obo:CL_4030023 (respiratory tract hillock cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref ) Annotation(oboInOwl:hasDbXref "PMID:30069044") Annotation(oboInOwl:hasDbXref "PMID:32726565") Annotation(oboInOwl:hasDbXref "PMID:33442032") obo:IAO_0000115 obo:CL_4030023 "A hillock cell that is located in respiratory epithelium. In some mammalian species, this cell type has been noted to express KRT13 and KRT4 and is postulated to play a role in squamous barrier function and immunomodulation.")
AnnotationAssertion(terms:date obo:CL_4030023 "2022-06-06T08:31:09Z"^^xsd:dateTime)
-AnnotationAssertion(oboInOwl:hasNarrowSynonym obo:CL_4030023 "hillock cell of respiratory tract")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030023 "hillock cell of respiratory tract")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030023 "respiratory hillock cell")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4030023 cl:cellxgene_subset)
-AnnotationAssertion(rdfs:label obo:CL_4030023 "respiratory hillock cell")
+AnnotationAssertion(rdfs:label obo:CL_4030023 "respiratory tract hillock cell")
EquivalentClasses(obo:CL_4030023 ObjectIntersectionOf(obo:CL_4030024 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802)))
SubClassOf(obo:CL_4030023 obo:CL_0002368)
SubClassOf(obo:CL_4030023 obo:CL_4030024)
@@ -38472,12 +39298,12 @@ EquivalentClasses(obo:CL_4030025 ObjectIntersectionOf(obo:CL_0000057 ObjectSomeV
SubClassOf(obo:CL_4030025 obo:CL_1000681)
SubClassOf(obo:CL_4030025 obo:CL_1000692)
-# Class: obo:CL_4030026 (BEST4+ enteroycte)
+# Class: obo:CL_4030026 (BEST4+ enterocyte)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref ) Annotation(oboInOwl:hasDbXref "PMID:24223998") Annotation(oboInOwl:hasDbXref "PMID:35176508") obo:IAO_0000115 obo:CL_4030026 "An enterocyte of the human intestine expressing bestrophin-4 (BEST4) calcium-activated ion channels.")
AnnotationAssertion(terms:date obo:CL_4030026 "2022-09-07T12:34:20Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4030026 cl:cellxgene_subset)
-AnnotationAssertion(rdfs:label obo:CL_4030026 "BEST4+ enteroycte")
+AnnotationAssertion(rdfs:label obo:CL_4030026 "BEST4+ enterocyte")
EquivalentClasses(obo:CL_4030026 ObjectIntersectionOf(obo:CL_0000584 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_Q8NFU0)))
SubClassOf(obo:CL_4030026 obo:CL_0000584)
SubClassOf(obo:CL_4030026 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606))
@@ -38497,11 +39323,9 @@ SubClassOf(obo:CL_4030027 obo:CL_0011005)
# Class: obo:CL_4030028 (glycinergic amacrine cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.1016/j.cell.2020.08.013") obo:IAO_0000115 obo:CL_4030028 "An amacrine cell that uses glycine as a neurotransmitter.")
-AnnotationAssertion(obo:RO_0002175 obo:CL_4030028 obo:NCBITaxon_9606)
AnnotationAssertion(terms:date obo:CL_4030028 "2022-10-17T12:40:06Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030028 "amacrine cell, glycinergic")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4030028 cl:cellxgene_subset)
-AnnotationAssertion(oboInOwl:inSubset obo:CL_4030028 core:human_reference_atlas)
AnnotationAssertion(rdfs:label obo:CL_4030028 "glycinergic amacrine cell")
EquivalentClasses(obo:CL_4030028 ObjectIntersectionOf(obo:CL_0000561 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061537)))
SubClassOf(obo:CL_4030028 obo:CL_0000561)
@@ -38544,6 +39368,7 @@ AnnotationAssertion(terms:date obo:CL_4030032 "2022-12-06T14:18:45Z"^^xsd:dateTi
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25311230") Annotation(oboInOwl:hasDbXref "PMID:30796046") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasExactSynonym obo:CL_4030032 "VIC")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030032 "cardiac valve interstitial cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25311230") oboInOwl:hasExactSynonym obo:CL_4030032 "valvular interstitial cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_4030032 cl:cellxgene_subset)
AnnotationAssertion(oboInOwl:inSubset obo:CL_4030032 core:human_reference_atlas)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25311230") rdfs:comment obo:CL_4030032 "Activated valve interstitial cells undergo continual turn over into deactivated fibroblasts and other cell fates (such as apoptosis).")
AnnotationAssertion(rdfs:label obo:CL_4030032 "valve interstitial cell")
@@ -38559,21 +39384,26 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25311230") obo:IAO_00001
AnnotationAssertion(terms:date obo:CL_4030033 "2022-12-09T11:58:49Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25311230") Annotation(oboInOwl:hasDbXref "PMID:30796046") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasExactSynonym obo:CL_4030033 "VEC")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25311230") oboInOwl:hasExactSynonym obo:CL_4030033 "valvular endothelial cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_4030033 cl:cellxgene_subset)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25311230") rdfs:comment obo:CL_4030033 "At least in some mammalian species, a valve endothelial cell expresses CD31. Valve endothelial cells can undergo an endothelial to mesenchymal transition to acquire a fibroblast or myofibroblast phenotype that leads to changes in the microenvironmental signals and facilitates tissue regeneration.")
AnnotationAssertion(rdfs:label obo:CL_4030033 "valve endothelial cell")
EquivalentClasses(obo:CL_4030033 ObjectIntersectionOf(obo:CL_0000115 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000946)))
SubClassOf(obo:CL_4030033 obo:CL_0010008)
SubClassOf(obo:CL_4030033 obo:CL_1000147)
-# Class: obo:CL_4030034 (respiratory ciliated cell)
+# Class: obo:CL_4030034 (respiratory tract multiciliated cell)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18757316") Annotation(oboInOwl:hasDbXref "PMID:21364219") obo:IAO_0000115 obo:CL_4030034 "A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18757316") Annotation(oboInOwl:hasDbXref "PMID:21364219") Annotation(oboInOwl:hasDbXref "PMID:34044844") Annotation(oboInOwl:hasDbXref "PMID:37834236") obo:IAO_0000115 obo:CL_4030034 "A multiciliated epithelial cell located in the respiratory tract epithelium, characterized by a columnar shape and motile cilia on its apical surface. This cell develops through a highly orchestrated process, transitioning from a basal progenitor via an intermediate deuterosomal cell stage that generates centrioles essential for ciliogenesis.")
AnnotationAssertion(terms:date obo:CL_4030034 "2023-01-25T11:06:01Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030034 "ciliated cell of the respiratory tract")
-AnnotationAssertion(rdfs:label obo:CL_4030034 "respiratory ciliated cell")
-EquivalentClasses(obo:CL_4030034 ObjectIntersectionOf(obo:CL_0000064 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802)))
-SubClassOf(obo:CL_4030034 obo:CL_0000064)
-SubClassOf(obo:CL_4030034 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802))
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030034 "respiratory ciliated cell")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030034 "respiratory multiciliated cell")
+AnnotationAssertion(rdfs:label obo:CL_4030034 "respiratory tract multiciliated cell")
+EquivalentClasses(obo:CL_4030034 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031514) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007)))
+SubClassOf(obo:CL_4030034 obo:CL_0002368)
+SubClassOf(obo:CL_4030034 obo:CL_0005012)
+SubClassOf(obo:CL_4030034 obo:UBERON_0004119)
+SubClassOf(obo:CL_4030034 ObjectSomeValuesFrom(obo:RO_0002207 obo:CL_4033044))
# Class: obo:CL_4030035 (dental pulp stem cell)
@@ -38631,37 +39461,40 @@ AnnotationAssertion(rdfs:label obo:CL_4030039 "von Economo neuron")
SubClassOf(obo:CL_4030039 obo:CL_4023009)
SubClassOf(obo:CL_4030039 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070006))
-# Class: obo:CL_4030040 (endometrial ciliated epithelial cell)
+# Class: obo:CL_4030040 (endometrial multiciliated epithelial cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31290979") Annotation(oboInOwl:hasDbXref "PMID:37999981") Annotation(oboInOwl:hasDbXref "doi:10.1016/j.coemr.2024.100503") Annotation(oboInOwl:hasDbXref "doi:10.1038/s41591-020-1040-z") Annotation(oboInOwl:hasDbXref "https://www.proteinatlas.org/humanproteome/single+cell+type/Glandular+epithelial+cells#endometrialciliatedcells") obo:IAO_0000115 obo:CL_4030040 "A multi-ciliated cell of the endometrial epithelium. This cell is characterized by the presence of 9+2 motile cilia on its apical surface, which facilitates the movement of mucus across the endometrial surface.")
AnnotationAssertion(terms:date obo:CL_4030040 "2023-02-09T11:25:14Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_4030040 "ciliated cell of the uterus")
AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_4030040 "uterine ciliated cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030040 "ciliated cell of the endometrium")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030040 "endometrial ciliated epithelial cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030040 "endometrium ciliated epithelial cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "ttps://www.nature.com/articles/s41591-020-1040-z") rdfs:comment obo:CL_4030040 "In human samples, the expression of FOXJ1 protein, a regulator for motile cilia with epithelial lineage identity, has been noted.")
-AnnotationAssertion(rdfs:label obo:CL_4030040 "endometrial ciliated epithelial cell")
-EquivalentClasses(obo:CL_4030040 ObjectIntersectionOf(obo:CL_0005012 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004811) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0097729)))
+AnnotationAssertion(rdfs:label obo:CL_4030040 "endometrial multiciliated epithelial cell")
+EquivalentClasses(obo:CL_4030040 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004811) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0097729) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007)))
SubClassOf(obo:CL_4030040 obo:CL_0002149)
SubClassOf(obo:CL_4030040 obo:CL_0005012)
SubClassOf(obo:CL_4030040 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004811))
SubClassOf(obo:CL_4030040 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0097729))
-# Class: obo:CL_4030041 (luminal endometrial ciliated epithelial cell)
+# Class: obo:CL_4030041 (luminal endometrial multiciliated epithelial cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1038/s41591-020-1040-z") obo:IAO_0000115 obo:CL_4030041 "A ciliated cell of the endometrial luminal epithelium. This cell is characterized by the presence of motile cilia on its apical surface.")
AnnotationAssertion(terms:date obo:CL_4030041 "2023-02-09T11:34:42Z"^^xsd:dateTime)
-AnnotationAssertion(rdfs:label obo:CL_4030041 "luminal endometrial ciliated epithelial cell")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030041 "luminal endometrial ciliated epithelial cell")
+AnnotationAssertion(rdfs:label obo:CL_4030041 "luminal endometrial multiciliated epithelial cell")
SubClassOf(obo:CL_4030041 obo:CL_4030040)
SubClassOf(obo:CL_4030041 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0011949))
-# Class: obo:CL_4030042 (glandular endometrial ciliated epithelial cell)
+# Class: obo:CL_4030042 (glandular endometrial multiciliated epithelial cell)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1038/s41591-020-1040-z") obo:IAO_0000115 obo:CL_4030042 "A ciliated cell of the endometrial glandular epithelium. This cell is characterized by the presence of motile cilia on its apical surface.")
AnnotationAssertion(terms:date obo:CL_4030042 "2023-02-09T11:37:30Z"^^xsd:dateTime)
-AnnotationAssertion(rdfs:label obo:CL_4030042 "glandular endometrial ciliated epithelial cell")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030042 "glandular endometrial ciliated epithelial cell")
+AnnotationAssertion(rdfs:label obo:CL_4030042 "glandular endometrial multiciliated epithelial cell")
+SubClassOf(obo:CL_4030042 obo:CL_0009084)
SubClassOf(obo:CL_4030042 obo:CL_4030040)
-SubClassOf(obo:CL_4030042 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0012276))
# Class: obo:CL_4030043 (matrix D1 medium spiny neuron)
@@ -38672,6 +39505,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4030043 "matrix D1-MSN")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") rdfs:comment obo:CL_4030043 "In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways.")
AnnotationAssertion(rdfs:label obo:CL_4030043 "matrix D1 medium spiny neuron")
+SubClassOf(obo:CL_4030043 obo:CL_0002613)
SubClassOf(obo:CL_4030043 obo:CL_4023026)
SubClassOf(obo:CL_4030043 ObjectSomeValuesFrom(obo:RO_0002100 ObjectIntersectionOf(obo:UBERON_0027368 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005382))))
@@ -38684,6 +39518,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4030047 "matrix D2-MSN")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") rdfs:comment obo:CL_4030047 "In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways.")
AnnotationAssertion(rdfs:label obo:CL_4030047 "matrix D2 medium spiny neuron")
+SubClassOf(obo:CL_4030047 obo:CL_0002613)
SubClassOf(obo:CL_4030047 obo:CL_4023029)
SubClassOf(obo:CL_4030047 ObjectSomeValuesFrom(obo:RO_0002100 ObjectIntersectionOf(obo:UBERON_0027368 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005382))))
@@ -38697,6 +39532,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4030048 "striosome D1-MSN")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") rdfs:comment obo:CL_4030048 "In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons.")
AnnotationAssertion(rdfs:label obo:CL_4030048 "striosomal D1 medium spiny neuron")
+SubClassOf(obo:CL_4030048 obo:CL_0002613)
SubClassOf(obo:CL_4030048 obo:CL_4023026)
SubClassOf(obo:CL_4030048 ObjectSomeValuesFrom(obo:RO_0002100 ObjectIntersectionOf(obo:UBERON_0027371 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005382))))
@@ -38710,6 +39546,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4030049 "striosome D2-MSN")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") rdfs:comment obo:CL_4030049 "In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons.")
AnnotationAssertion(rdfs:label obo:CL_4030049 "striosomal D2 medium spiny neuron")
+SubClassOf(obo:CL_4030049 obo:CL_0002613)
SubClassOf(obo:CL_4030049 obo:CL_4023029)
SubClassOf(obo:CL_4030049 ObjectSomeValuesFrom(obo:RO_0002100 ObjectIntersectionOf(obo:UBERON_0027371 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005382))))
@@ -38724,6 +39561,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") rdfs:comment obo:CL_4030050 "It has been noted in non-human primate species that the D1/D2-hybrid medium spiny neuron (D1/2) cell type shows the same amount of DRD1 expression as nearby D1 medium spiny neurons but far less DRD2 expression compared to nearby D2 medium spiny neurons. In Rhesus macaques, RXFP1 has been noted as a highly specific marker gene for the D1/2 cell type. The D1/2 cell type has also been described as having characteristics similar to a novel medium spiny neuron described in rodents (D1H or eccentric spiny projection neuron). Although an extrastriosomal cell type, the D1/2 cell type had been noted to express many of the genes associated with striosome, suggesting a possible homology to ‘‘exo-patch’’ cells.")
AnnotationAssertion(rdfs:label obo:CL_4030050 "D1/D2-hybrid medium spiny neuron")
SubClassOf(obo:CL_4030050 obo:BFO_0000002)
+SubClassOf(obo:CL_4030050 obo:CL_0002613)
SubClassOf(obo:CL_4030050 obo:CL_1001474)
SubClassOf(obo:CL_4030050 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005382))
SubClassOf(obo:CL_4030050 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000001175))
@@ -38739,6 +39577,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") rdfs:comment obo:CL_4030051 "In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4.")
AnnotationAssertion(rdfs:label obo:CL_4030051 "nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron")
SubClassOf(obo:CL_4030051 obo:BFO_0000002)
+SubClassOf(obo:CL_4030051 obo:CL_0002613)
SubClassOf(obo:CL_4030051 obo:CL_1001474)
SubClassOf(obo:CL_4030051 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005403))
SubClassOf(obo:CL_4030051 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000001175))
@@ -38754,6 +39593,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") rdfs:comment obo:CL_4030052 "In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4.")
AnnotationAssertion(rdfs:label obo:CL_4030052 "nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron")
SubClassOf(obo:CL_4030052 obo:BFO_0000002)
+SubClassOf(obo:CL_4030052 obo:CL_0002613)
SubClassOf(obo:CL_4030052 obo:CL_1001474)
SubClassOf(obo:CL_4030052 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005403))
SubClassOf(obo:CL_4030052 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000001177))
@@ -38765,6 +39605,7 @@ AnnotationAssertion(terms:date obo:CL_4030053 "2023-06-14T13:37:45Z"^^xsd:dateTi
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4030053 "D1-ICj")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") rdfs:comment obo:CL_4030053 "In Rhesus macaques, the Island of Calleja granule cell type has been noted to have enriched gene expression of CPNE4.")
AnnotationAssertion(rdfs:label obo:CL_4030053 "Island of Calleja granule cell")
+SubClassOf(obo:CL_4030053 obo:BFO_0000002)
SubClassOf(obo:CL_4030053 obo:CL_0000120)
SubClassOf(obo:CL_4030053 obo:CL_0002613)
SubClassOf(obo:CL_4030053 ObjectSomeValuesFrom(obo:RO_0002100 ObjectIntersectionOf(obo:UBERON_0001881 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005403))))
@@ -38779,6 +39620,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015") rdfs:comment obo:CL_4030054 "Regarding the abbreviation D1-NUDAP, NUDAP stands for \"neurochemically unique domains in the accumbens and putamen\". In Rhesus macaques, the RXFP1-positive interface island D1-medium spiny neuron (D1-NUDAP) has been noted to have upregulation of OPRM1 compared to DRD1-expressing medium spiny neurons located outside of the D1-exclusive island and in Islands of Calleja. Kappa-opioid receptor gene (OPRK1) has been noted to be absent from D1-NUDAP cells. Many striosome-specific markers have been noted to be upregulated in D1-NUDAP cells, including KCNIP1, KCNT1, KHDRBS3, and BACH2. PDYN, an acknowledged D1-striosome marker gene, has also been noted to be expressed in D1-NUDAPs. D1-NUDAPs also express some genes found to be selectively expressed in the matrix, including STXBP6, GDA, and SEMA3E. Gene enrichment analysis has revealed that D1-NUDAP neurons express genes that have been implicated in drug addiction and many other functions.")
AnnotationAssertion(rdfs:label obo:CL_4030054 "RXFP1-positive interface island D1-medium spiny neuron")
SubClassOf(obo:CL_4030054 obo:BFO_0000002)
+SubClassOf(obo:CL_4030054 obo:CL_0002613)
SubClassOf(obo:CL_4030054 obo:CL_1001474)
SubClassOf(obo:CL_4030054 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005403))
SubClassOf(obo:CL_4030054 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000001175))
@@ -38834,22 +39676,25 @@ AnnotationAssertion(Annotation(oboInOwl:SynonymTypeProperty obo:OMO_0003000) Ann
AnnotationAssertion(rdfs:label obo:CL_4030058 "TCR-positive macrophage")
EquivalentClasses(obo:CL_4030058 ObjectIntersectionOf(obo:CL_0000235 ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0042101)))
SubClassOf(obo:CL_4030058 obo:CL_0000235)
-SubClassOf(obo:CL_4030058 obo:PR_000050567)
SubClassOf(obo:CL_4030058 ObjectSomeValuesFrom(obo:RO_0002104 obo:GO_0042101))
# Class: obo:CL_4030059 (L2/3 intratelencephalic projecting glutamatergic neuron)
AnnotationAssertion(obo:IAO_0000028 obo:CL_4030059 "L2/3 IT")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25622573") Annotation(oboInOwl:hasDbXref "PMID:34004146") Annotation(oboInOwl:hasDbXref "PMID:37292694") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/") obo:IAO_0000115 obo:CL_4030059 "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found between cortical layer 2-4. This intratelencephalic-projecting glutamatergic neuron has thin-tufted apical dendrites and extends its axonal projection into L5 in the neocortex. This neuronal type has a hyperpolarised resting membrane potential. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L2/3 IT.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4030059 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4030059 )
AnnotationAssertion(terms:date obo:CL_4030059 "2023-10-10T14:10:21Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_4030059 "ILX:0770156")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34004146") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4030059 "L2/3 IT")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_4030059 cl:cellxgene_subset)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37824655") rdfs:comment obo:CL_4030059 "Hystorically, the L2/3 intratelencephalic projectic glutametergic neuron was known to have its soma in cortical layer 2/3. MERFISH data showed that this intratelencephalic-projecting glutametergic neuron can have its soma in layer 2/3, 4B, 4C. The position of the soma in layer 4b and 4C is less frequent for this neuronal type in comparison to cortical layer 2/3.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4030059 "The marker set ONECUT2, COL5A2 can identify the Human cell type L2/3 intratelencephalic projecting glutamatergic neuron in the Brain with a confidence of 0.670149932 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4030059 "L2/3 intratelencephalic projecting glutamatergic neuron")
EquivalentClasses(obo:CL_4030059 ObjectIntersectionOf(obo:CL_4023040 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_8440000)))
SubClassOf(obo:CL_4030059 obo:CL_4023040)
SubClassOf(obo:CL_4030059 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_8440000))
+SubClassOf(obo:CL_4030059 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000065))
# Class: obo:CL_4030060 (L2 intratelencephalic projecting glutamatergic neuron)
@@ -38891,40 +39736,50 @@ SubClassOf(obo:CL_4030062 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_8440001
AnnotationAssertion(obo:IAO_0000028 obo:CL_4030063 "L4 IT")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37292694") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/") obo:IAO_0000115 obo:CL_4030063 "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3-4. This neuron type can have a pyramidal, star-pyramidal or spiny stellate morphology and projects its output to L2/3 and L5A/B. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L4 IT.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4030063 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4030063 )
AnnotationAssertion(terms:date obo:CL_4030063 "2023-10-10T14:11:25Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37292694") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4030063 "L4 IT")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_4030063 cl:cellxgene_subset)
AnnotationAssertion(rdfs:comment obo:CL_4030063 "Historically, the L4 intratelencephalic projectic glutametergic neuron was known to have its soma in cortical layer 4. MERFISH data showed that this intratelencephalic-projecting glutametergic neuron can also have its soma in layer 3.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4030063 "The marker set RORB, ST8SIA4 can identify the Human cell type L4 intratelencephalic projecting glutamatergic neuron in the Brain with a confidence of 0.720108696 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4030063 "L4 intratelencephalic projecting glutamatergic neuron")
EquivalentClasses(obo:CL_4030063 ObjectIntersectionOf(obo:CL_4023040 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005393)))
SubClassOf(obo:CL_4030063 obo:CL_4023040)
SubClassOf(obo:CL_4030063 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005393))
+SubClassOf(obo:CL_4030063 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000066))
# Class: obo:CL_4030064 (L5 intratelencephalic projecting glutamatergic neuron)
AnnotationAssertion(obo:IAO_0000028 obo:CL_4030064 "L5 IT")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37292694") Annotation(oboInOwl:hasDbXref "PMID:37609206") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/") obo:IAO_0000115 obo:CL_4030064 "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L5 IT.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4030064 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4030064 )
AnnotationAssertion(terms:date obo:CL_4030064 "2023-10-10T14:11:59Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_4030064 "ILX:0770157")
AnnotationAssertion(Annotation(oboInOwl:SynonymTypeProperty obo:OMO_0003000) Annotation(oboInOwl:hasDbXref "PMID:37292694") oboInOwl:hasRelatedSynonym obo:CL_4030064 "L5 IT")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4030064 "The marker set ARSJ, RORB, KCNK2 can identify the Human cell type L5 intratelencephalic projecting glutamatergic neuron in the Brain with a confidence of 0.764261336 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4030064 "L5 intratelencephalic projecting glutamatergic neuron")
EquivalentClasses(obo:CL_4030064 ObjectIntersectionOf(obo:CL_4023040 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005394)))
SubClassOf(obo:CL_4030064 obo:CL_4023040)
SubClassOf(obo:CL_4030064 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005394))
+SubClassOf(obo:CL_4030064 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000068))
# Class: obo:CL_4030065 (L6 intratelencephalic projecting glutamatergic neuron)
AnnotationAssertion(obo:IAO_0000028 obo:CL_4030065 "L6 IT")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37292694") Annotation(oboInOwl:hasDbXref "PMID:37609206") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/") obo:IAO_0000115 obo:CL_4030065 "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L6 IT.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4030065 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4030065 )
AnnotationAssertion(terms:date obo:CL_4030065 "2023-10-10T14:12:23Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_4030065 "ILX:0770158")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37292694") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4030065 "L6 IT")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4030065 "The marker set LINC00507, THEMIS can identify the Human cell type L6 intratelencephalic projecting glutamatergic neuron in the Brain with a confidence of 0.641695703 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4030065 "L6 intratelencephalic projecting glutamatergic neuron")
EquivalentClasses(obo:CL_4030065 ObjectIntersectionOf(obo:CL_4023040 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005395)))
SubClassOf(obo:CL_4030065 obo:CL_4023040)
SubClassOf(obo:CL_4030065 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0005395))
+SubClassOf(obo:CL_4030065 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000071))
# Class: obo:CL_4030066 (ureteric bud cell)
@@ -38932,6 +39787,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:17133361") Annotation(ob
AnnotationAssertion(terms:contributor obo:CL_4030066 "https://orcid.org/0000-0002-1425-877X")
AnnotationAssertion(terms:date obo:CL_4030066 "2023-10-13T11:22:42Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:24183650") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4030066 "UB cell")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_4030066 cl:cellxgene_subset)
AnnotationAssertion(rdfs:label obo:CL_4030066 "ureteric bud cell")
EquivalentClasses(obo:CL_4030066 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000084)))
SubClassOf(obo:CL_4030066 obo:BFO_0000002)
@@ -38943,18 +39799,23 @@ SubClassOf(Annotation(oboInOwl:hasDbXref "PMID:9374839") obo:CL_4030066 ObjectSo
# Class: obo:CL_4030067 (L5/6 near-projecting glutamatergic neuron)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34004146") Annotation(oboInOwl:hasDbXref "PMID:37292694") Annotation(oboInOwl:hasDbXref "PMID:37824655") obo:IAO_0000115 obo:CL_4030067 "A near-projecting glutamatergic neuron with a soma found in cortical layer 5/6.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4030067 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4030067 )
AnnotationAssertion(terms:date obo:CL_4030067 "2023-11-17T11:35:06Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34004146") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4030067 "L5/6 NP")
+AnnotationAssertion(oboInOwl:inSubset obo:CL_4030067 cl:cellxgene_subset)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918") rdfs:comment obo:CL_4030067 "The marker set NPSR1-AS1, TLL1 can identify the Human cell type L5/6 near-projecting glutamatergic neuron in the Brain with a confidence of 0.899288218 (NS-Forest FBeta value).")
AnnotationAssertion(rdfs:label obo:CL_4030067 "L5/6 near-projecting glutamatergic neuron")
EquivalentClasses(obo:CL_4030067 ObjectIntersectionOf(obo:CL_4023012 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_8440002)))
SubClassOf(obo:CL_4030067 obo:CL_4023012)
SubClassOf(obo:CL_4030067 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_8440002))
+SubClassOf(obo:CL_4030067 ObjectSomeValuesFrom(obo:RO_0015004 obo:CLM_1000069))
# Class: obo:CL_4030068 (L6 intratelencephalic projecting Car3 glutamatergic neuron)
AnnotationAssertion(obo:IAO_0000028 obo:CL_4030068 "L6 IT Car3")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34004146") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "doi:10.1007/s00424-024-02923-2") Annotation(oboInOwl:hasDbXref "doi:10.1101/2022.11.30.518285") obo:IAO_0000115 obo:CL_4030068 "A transcriptomically distinct intratelencepalic-projecting glutamatergic neuron that expresses Car3 with a soma found in L6 . The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_cluster', L6 IT Car3.")
+AnnotationAssertion(obo:RO_0002175 obo:CL_4030068 obo:NCBITaxon_9606)
AnnotationAssertion(terms:contributor obo:CL_4030068 )
AnnotationAssertion(terms:date obo:CL_4030068 "2023-11-23T09:16:14Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref