diff --git a/src/bindgen/language_backend/clike.rs b/src/bindgen/language_backend/clike.rs
index 3830b02a..553354e8 100644
--- a/src/bindgen/language_backend/clike.rs
+++ b/src/bindgen/language_backend/clike.rs
@@ -902,6 +902,18 @@ impl LanguageBackend for CLikeLanguageBackend<'_> {
                     write!(out, "{}", export_name);
                 }
 
+                macro_rules! write_field_name {
+                    ($out:ident, $key:ident) => {
+                        if self.config.language == Language::Cxx {
+                            // TODO: Some C++ versions (c++20?) now support designated
+                            // initializers, consider generating them.
+                            write!($out, "/* .{} = */ ", $key);
+                        } else {
+                            write!($out, ".{} = ", $key);
+                        }
+                    };
+                }
+
                 write!(out, "{{");
                 if is_constexpr {
                     out.push_tab();
@@ -912,12 +924,11 @@ impl LanguageBackend for CLikeLanguageBackend<'_> {
                 let ordered_fields = out.bindings().struct_field_names(path);
                 for (i, ordered_key) in ordered_fields.iter().enumerate() {
                     if let Some(lit) = fields.get(ordered_key) {
+                        let condition = lit.cfg.to_condition(self.config);
                         if is_constexpr {
                             out.new_line();
 
-                            // TODO: Some C++ versions (c++20?) now support designated
-                            // initializers, consider generating them.
-                            write!(out, "/* .{} = */ ", ordered_key);
+                            write_field_name!(out, ordered_key);
                             self.write_literal(out, &lit.value);
                             if i + 1 != ordered_fields.len() {
                                 write!(out, ",");
@@ -930,14 +941,14 @@ impl LanguageBackend for CLikeLanguageBackend<'_> {
                                 write!(out, ", ");
                             }
 
-                            if self.config.language == Language::Cxx {
-                                // TODO: Some C++ versions (c++20?) now support designated
-                                // initializers, consider generating them.
-                                write!(out, "/* .{} = */ ", ordered_key);
+                            if condition.is_some() {
+                                write!(out, "__{export_name}_{ordered_key}(");
+                                self.write_literal(out, &lit.value);
+                                write!(out, ")")
                             } else {
-                                write!(out, ".{} = ", ordered_key);
+                                write_field_name!(out, ordered_key);
+                                self.write_literal(out, &lit.value);
                             }
-                            self.write_literal(out, &lit.value);
                         }
                     }
                 }
@@ -948,6 +959,24 @@ impl LanguageBackend for CLikeLanguageBackend<'_> {
                     write!(out, " ");
                 }
                 write!(out, "}}");
+
+                if self.config.language == Language::C {
+                    for ordered_key in ordered_fields.iter() {
+                        if let Some(lit) = fields.get(ordered_key) {
+                            if let Some(condition) = lit.cfg.to_condition(self.config) {
+                                out.new_line();
+                                condition.write_before(self.config, out);
+                                let define = format!("#define __{export_name}_{ordered_key}(v)");
+                                write!(out, "{define} ");
+                                write_field_name!(out, ordered_key);
+                                write!(out, "(v)");
+                                write!(out, "\n#else\n");
+                                write!(out, "{define}");
+                                condition.write_after(self.config, out);
+                            }
+                        }
+                    }
+                }
             }
         }
     }
diff --git a/tests/expectations/cfg.c b/tests/expectations/cfg.c
index 9285f300..b4115096 100644
--- a/tests/expectations/cfg.c
+++ b/tests/expectations/cfg.c
@@ -77,6 +77,18 @@ typedef struct {
 #endif
   ;
 } ConditionalField;
+#define ConditionalField_ZERO (ConditionalField){ __ConditionalField_field(0) }
+#if defined(X11)
+#define __ConditionalField_field(v) .field = (v)
+#else
+#define __ConditionalField_field(v)
+#endif
+#define ConditionalField_ONE (ConditionalField){ __ConditionalField_field(1) }
+#if defined(X11)
+#define __ConditionalField_field(v) .field = (v)
+#else
+#define __ConditionalField_field(v)
+#endif
 
 typedef struct {
   int32_t x;
diff --git a/tests/expectations/cfg.compat.c b/tests/expectations/cfg.compat.c
index 053c4052..73d9f6ed 100644
--- a/tests/expectations/cfg.compat.c
+++ b/tests/expectations/cfg.compat.c
@@ -95,6 +95,18 @@ typedef struct {
 #endif
   ;
 } ConditionalField;
+#define ConditionalField_ZERO (ConditionalField){ __ConditionalField_field(0) }
+#if defined(X11)
+#define __ConditionalField_field(v) .field = (v)
+#else
+#define __ConditionalField_field(v)
+#endif
+#define ConditionalField_ONE (ConditionalField){ __ConditionalField_field(1) }
+#if defined(X11)
+#define __ConditionalField_field(v) .field = (v)
+#else
+#define __ConditionalField_field(v)
+#endif
 
 typedef struct {
   int32_t x;
diff --git a/tests/expectations/cfg.cpp b/tests/expectations/cfg.cpp
index d7b6250d..1cd0447a 100644
--- a/tests/expectations/cfg.cpp
+++ b/tests/expectations/cfg.cpp
@@ -201,6 +201,12 @@ struct ConditionalField {
 #endif
   ;
 };
+constexpr static const ConditionalField ConditionalField_ZERO = ConditionalField{ 
+  /* .field = */ 0
+};
+constexpr static const ConditionalField ConditionalField_ONE = ConditionalField{ 
+  /* .field = */ 1
+};
 
 struct Normal {
   int32_t x;
diff --git a/tests/expectations/cfg.pyx b/tests/expectations/cfg.pyx
index e23fc703..803fd7a7 100644
--- a/tests/expectations/cfg.pyx
+++ b/tests/expectations/cfg.pyx
@@ -57,6 +57,8 @@ cdef extern from *:
 
   ctypedef struct ConditionalField:
     int32_t field;
+  const ConditionalField ConditionalField_ZERO # = <ConditionalField>{ 0 }
+  const ConditionalField ConditionalField_ONE # = <ConditionalField>{ 1 }
 
   ctypedef struct Normal:
     int32_t x;
diff --git a/tests/expectations/cfg_both.c b/tests/expectations/cfg_both.c
index 510e34e8..7d0d639c 100644
--- a/tests/expectations/cfg_both.c
+++ b/tests/expectations/cfg_both.c
@@ -77,6 +77,18 @@ typedef struct ConditionalField {
 #endif
   ;
 } ConditionalField;
+#define ConditionalField_ZERO (ConditionalField){ __ConditionalField_field(0) }
+#if defined(X11)
+#define __ConditionalField_field(v) .field = (v)
+#else
+#define __ConditionalField_field(v)
+#endif
+#define ConditionalField_ONE (ConditionalField){ __ConditionalField_field(1) }
+#if defined(X11)
+#define __ConditionalField_field(v) .field = (v)
+#else
+#define __ConditionalField_field(v)
+#endif
 
 typedef struct Normal {
   int32_t x;
diff --git a/tests/expectations/cfg_both.compat.c b/tests/expectations/cfg_both.compat.c
index 2377824e..6a06b78d 100644
--- a/tests/expectations/cfg_both.compat.c
+++ b/tests/expectations/cfg_both.compat.c
@@ -95,6 +95,18 @@ typedef struct ConditionalField {
 #endif
   ;
 } ConditionalField;
+#define ConditionalField_ZERO (ConditionalField){ __ConditionalField_field(0) }
+#if defined(X11)
+#define __ConditionalField_field(v) .field = (v)
+#else
+#define __ConditionalField_field(v)
+#endif
+#define ConditionalField_ONE (ConditionalField){ __ConditionalField_field(1) }
+#if defined(X11)
+#define __ConditionalField_field(v) .field = (v)
+#else
+#define __ConditionalField_field(v)
+#endif
 
 typedef struct Normal {
   int32_t x;
diff --git a/tests/expectations/cfg_tag.c b/tests/expectations/cfg_tag.c
index 8cc88538..ff84a233 100644
--- a/tests/expectations/cfg_tag.c
+++ b/tests/expectations/cfg_tag.c
@@ -77,6 +77,18 @@ struct ConditionalField {
 #endif
   ;
 };
+#define ConditionalField_ZERO (ConditionalField){ __ConditionalField_field(0) }
+#if defined(X11)
+#define __ConditionalField_field(v) .field = (v)
+#else
+#define __ConditionalField_field(v)
+#endif
+#define ConditionalField_ONE (ConditionalField){ __ConditionalField_field(1) }
+#if defined(X11)
+#define __ConditionalField_field(v) .field = (v)
+#else
+#define __ConditionalField_field(v)
+#endif
 
 struct Normal {
   int32_t x;
diff --git a/tests/expectations/cfg_tag.compat.c b/tests/expectations/cfg_tag.compat.c
index ec976353..b67a1bff 100644
--- a/tests/expectations/cfg_tag.compat.c
+++ b/tests/expectations/cfg_tag.compat.c
@@ -95,6 +95,18 @@ struct ConditionalField {
 #endif
   ;
 };
+#define ConditionalField_ZERO (ConditionalField){ __ConditionalField_field(0) }
+#if defined(X11)
+#define __ConditionalField_field(v) .field = (v)
+#else
+#define __ConditionalField_field(v)
+#endif
+#define ConditionalField_ONE (ConditionalField){ __ConditionalField_field(1) }
+#if defined(X11)
+#define __ConditionalField_field(v) .field = (v)
+#else
+#define __ConditionalField_field(v)
+#endif
 
 struct Normal {
   int32_t x;
diff --git a/tests/expectations/cfg_tag.pyx b/tests/expectations/cfg_tag.pyx
index e508bb30..6a0d44d7 100644
--- a/tests/expectations/cfg_tag.pyx
+++ b/tests/expectations/cfg_tag.pyx
@@ -57,6 +57,8 @@ cdef extern from *:
 
   cdef struct ConditionalField:
     int32_t field;
+  const ConditionalField ConditionalField_ZERO # = <ConditionalField>{ 0 }
+  const ConditionalField ConditionalField_ONE # = <ConditionalField>{ 1 }
 
   cdef struct Normal:
     int32_t x;
diff --git a/tests/rust/cfg.rs b/tests/rust/cfg.rs
index 70893609..0efe3546 100644
--- a/tests/rust/cfg.rs
+++ b/tests/rust/cfg.rs
@@ -49,6 +49,17 @@ struct ConditionalField {
     field: i32,
 }
 
+impl ConditionalField {
+    pub const ZERO: Self = Self {
+        #[cfg(x11)]
+        field: 0,
+    };
+    pub const ONE: Self = Self {
+        #[cfg(x11)]
+        field: 1,
+    };
+}
+
 #[cfg(all(unix, x11))]
 #[no_mangle]
 pub extern "C" fn root(a: FooHandle, c: C)