diff --git a/mesonbuild/backend/xcodebackend.py b/mesonbuild/backend/xcodebackend.py
index 31fd272b3f0b..57a901fdfdf1 100644
--- a/mesonbuild/backend/xcodebackend.py
+++ b/mesonbuild/backend/xcodebackend.py
@@ -1770,7 +1770,11 @@ def generate_single_build_target(self, objects_dict, target_name, target) -> Non
                     i = os.path.normpath(i)
                     unquoted_headers.append(i)
             for i in unquoted_headers:
-                header_arr.add_item(f'"{i}"')
+                if ' ' in i:
+                    # Make sure Xcode will not split single path into separate entries, escaping just space won't help
+                    header_arr.add_item(f'"\\\"{i}\\\""')
+                else:
+                    header_arr.add_item(f'"{i}"')
             settings_dict.add_item('HEADER_SEARCH_PATHS', header_arr)
             settings_dict.add_item('INSTALL_PATH', install_path)
             settings_dict.add_item('LIBRARY_SEARCH_PATHS', '')