How to quantify evidence of co-functionality?

[llrs]

From Bioinformatics:

"quantify how likely two genes are correlated in their enrichment, function etc. For example, using STRING we can see that PIK3CA and PTEN are more co-functioning than PIK3CA and SF3B1. "

The question is how to add this higher co-functioning evidence in BioCor? My answer is that this should be two separate metrics.