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Hi,
Firstly, I think you should check the dir, the default value of the destination dir given as 'data/work' may not right in your dir structure.
Secondly ,you should ensure the prarent dir is created in advance. Doing like this:
os.makedirs(save_dir, exist_ok=True)
save_file = os.path.join(opt.work_dir,opt.reference,'activesd.pckl')
with open(save_file, 'wb') as fil:
pickle.dump(dists, fil)
By doing so, it may help you to solve this problem.
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