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pyruvate metabolic process #29541

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ValWood opened this issue Jan 15, 2025 · 1 comment
Open

pyruvate metabolic process #29541

ValWood opened this issue Jan 15, 2025 · 1 comment
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@ValWood
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ValWood commented Jan 15, 2025

This seems ( along with the biosynthetic and catabolic process)
seem like unnecessary grouping terms.

It has the following descendants.

Everything annotated would be better described by the appropriate specific pathway terms.

GO:0042866    pyruvate biosynthetic process | is_a
GO:0042867    pyruvate catabolic process | is_a
GO:0046327    glycerol biosynthetic process from pyruvate | is_a
GO:0019272    L-alanine biosynthetic process from pyruvate | is_a
GO:0019450    L-cysteine catabolic process to pyruvate | is_a
GO:0061678    Entner-Doudoroff pathway | is_a
GO:0019244    lactate biosynthetic process from pyruvate | is_a
GO:0006086    acetyl-CoA biosynthetic process from pyruvate | is_a
GO:0006096    glycolytic process | is_a
GO:0061718    glucose catabolic process to pyruvate | is_a
GO:0019617    protocatechuate catabolic process, meta-cleavage | is_a
GO:0061722    sulphoglycolysis

Also, some of the children look suspect

@ValWood
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ValWood commented Jan 15, 2025

It's also inconsistent because the major pyruvate pyruvate-'producing' pathway , canonical glycolysis, is not a child.
It seems crazy to lump pathways under the metabolism of an end-point

I would also make the same comment about "lactate metabolism"

@raymond91125 raymond91125 self-assigned this Jan 16, 2025
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