diff --git a/src/ontology/go-edit.obo b/src/ontology/go-edit.obo index 63c0361930..2a96d7f41e 100644 --- a/src/ontology/go-edit.obo +++ b/src/ontology/go-edit.obo @@ -19949,7 +19949,7 @@ synonym: "nitric oxide production involved in acute inflammatory response" BROAD synonym: "production of nitric oxide involved in acute inflammatory response" BROAD [] synonym: "production of nitric oxide involved in inflammatory response" EXACT [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response -relationship: has_output CHEBI:16480 ! nitric oxide +relationship: has_primary_output CHEBI:16480 ! nitric oxide [Term] id: GO:0002538 @@ -58076,15 +58076,15 @@ xref: MetaCyc:GLYCOLYSIS-VARIANTS is_a: GO:0006091 ! generation of precursor metabolites and energy intersection_of: GO:0016052 ! carbohydrate catabolic process intersection_of: ends_with GO:0004743 ! pyruvate kinase activity -intersection_of: has_output CHEBI:13392 ! NAD(P)H -intersection_of: has_output CHEBI:30616 ! ATP(4-) intersection_of: has_part GO:0004618 ! phosphoglycerate kinase activity intersection_of: has_part GO:0004619 ! phosphoglycerate mutase activity intersection_of: has_part GO:0004634 ! phosphopyruvate hydratase activity intersection_of: has_part GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity intersection_of: has_primary_input CHEBI:13390 ! NAD(P)(+) intersection_of: has_primary_input CHEBI:456216 ! ADP(3-) +intersection_of: has_primary_output CHEBI:13392 ! NAD(P)H intersection_of: has_primary_output CHEBI:15361 ! pyruvate +intersection_of: has_primary_output CHEBI:30616 ! ATP(4-) property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21176" xsd:anyURI [Term] @@ -58113,9 +58113,9 @@ xref: Reactome:R-HSA-71336 "Pentose phosphate pathway (hexose monophosphate shun xref: Wikipedia:Pentose_phosphate_pathway intersection_of: GO:0008152 ! metabolic process intersection_of: ends_with GO:0009052 ! pentose-phosphate shunt, non-oxidative branch -intersection_of: has_output CHEBI:57783 ! NADPH(4-) intersection_of: has_primary_input CHEBI:14314 ! D-glucose 6-phosphate intersection_of: has_primary_input CHEBI:58349 ! NADP(3-) +intersection_of: has_primary_output CHEBI:57783 ! NADPH(4-) intersection_of: starts_with GO:0009051 ! pentose-phosphate shunt, oxidative branch [Term] @@ -58326,8 +58326,8 @@ synonym: "reduced NAD oxidation" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide dehydrogenation" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide oxidation" EXACT [] intersection_of: GO:0008152 ! metabolic process -intersection_of: has_output CHEBI:57540 ! NAD(1-) intersection_of: has_primary_input CHEBI:57945 ! NADH(2-) +intersection_of: has_primary_output CHEBI:57540 ! NAD(1-) property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21577" xsd:anyURI [Term] @@ -58451,12 +58451,12 @@ namespace: biological_process def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716720094, PMID:16368075] xref: MetaCyc:PWY-6118 intersection_of: GO:0008152 ! metabolic process -intersection_of: has_output CHEBI:57540 ! NAD(1-) intersection_of: has_part GO:0004368 ! glycerol-3-phosphate dehydrogenase (quinone) activity intersection_of: has_part GO:0047952 ! glycerol-3-phosphate dehydrogenase [NAD(P)+] activity intersection_of: has_participant CHEBI:57597 ! sn-glycerol 3-phosphate(2-) intersection_of: has_primary_input CHEBI:57945 ! NADH(2-) intersection_of: has_primary_input_or_output CHEBI:57642 ! glycerone phosphate(2-) +intersection_of: has_primary_output CHEBI:57540 ! NAD(1-) relationship: has_part GO:0047952 ! glycerol-3-phosphate dehydrogenase [NAD(P)+] activity relationship: part_of GO:0022904 ! respiratory electron transport chain @@ -58812,7 +58812,7 @@ is_a: GO:0043101 ! purine-containing compound salvage is_a: GO:0043174 ! nucleoside salvage is_a: GO:0046129 ! purine ribonucleoside biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:26399 ! purine ribonucleoside +intersection_of: has_primary_output CHEBI:26399 ! purine ribonucleoside [Term] id: GO:0006167 @@ -58836,7 +58836,7 @@ synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] is_a: GO:0043096 ! purine nucleobase salvage is_a: GO:0046084 ! adenine biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:16708 ! adenine +intersection_of: has_primary_output CHEBI:16708 ! adenine [Term] id: GO:0006169 @@ -58847,7 +58847,7 @@ synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046086 ! adenosine biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:16335 ! adenosine +intersection_of: has_primary_output CHEBI:16335 ! adenosine [Term] id: GO:0006170 @@ -58958,7 +58958,7 @@ synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] is_a: GO:0043096 ! purine nucleobase salvage is_a: GO:0046099 ! guanine biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:16235 ! guanine +intersection_of: has_primary_output CHEBI:16235 ! guanine [Term] id: GO:0006179 @@ -58969,7 +58969,7 @@ synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046114 ! guanosine biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:16750 ! guanosine +intersection_of: has_primary_output CHEBI:16750 ! guanosine [Term] id: GO:0006180 @@ -58978,7 +58978,7 @@ namespace: biological_process def: "Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis." [GOC:jl] is_a: GO:0043098 ! purine deoxyribonucleoside salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:17172 ! 2'-deoxyguanosine +intersection_of: has_primary_output CHEBI:17172 ! 2'-deoxyguanosine [Term] id: GO:0006181 @@ -59096,7 +59096,7 @@ synonym: "guanine, xanthine and their nucleoside salvage" RELATED [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046103 ! inosine biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:17596 ! inosine +intersection_of: has_primary_output CHEBI:17596 ! inosine [Term] id: GO:0006191 @@ -59106,7 +59106,7 @@ def: "Any process that generates deoxyinosine from derivatives of it, without de is_a: GO:0043098 ! purine deoxyribonucleoside salvage is_a: GO:0046095 ! deoxyinosine biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:28997 ! 2'-deoxyinosine +intersection_of: has_primary_output CHEBI:28997 ! 2'-deoxyinosine [Term] id: GO:0006192 @@ -59459,7 +59459,7 @@ def: "Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives o is_a: GO:0043100 ! pyrimidine nucleobase salvage is_a: GO:0046107 ! uracil biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:17568 ! uracil +intersection_of: has_primary_output CHEBI:17568 ! uracil [Term] id: GO:0006224 @@ -59611,7 +59611,7 @@ def: "Any process that generates cytidine, cytosine riboside, from derivatives o is_a: GO:0043097 ! pyrimidine nucleoside salvage is_a: GO:0046088 ! cytidine biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:17562 ! cytidine +intersection_of: has_primary_output CHEBI:17562 ! cytidine [Term] id: GO:0006237 @@ -59621,7 +59621,7 @@ def: "Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from der is_a: GO:0043099 ! pyrimidine deoxyribonucleoside salvage is_a: GO:0046093 ! deoxycytidine biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:15698 ! 2'-deoxycytidine +intersection_of: has_primary_output CHEBI:15698 ! 2'-deoxycytidine [Term] id: GO:0006238 @@ -59632,7 +59632,7 @@ synonym: "cytidine monophosphate salvage" EXACT [] is_a: GO:0009224 ! CMP biosynthetic process is_a: GO:0010138 ! pyrimidine ribonucleotide salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:60377 ! cytidine 5'-monophosphate(2-) +intersection_of: has_primary_output CHEBI:60377 ! cytidine 5'-monophosphate(2-) [Term] id: GO:0006239 @@ -59643,7 +59643,7 @@ synonym: "deoxycytidine monophosphate salvage" EXACT [] is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage is_a: GO:0046064 ! dCMP biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:57566 ! 2'-deoxycytosine 5'-monophosphate(2-) +intersection_of: has_primary_output CHEBI:57566 ! 2'-deoxycytosine 5'-monophosphate(2-) [Term] id: GO:0006240 @@ -62632,7 +62632,7 @@ synonym: "glutamate degradation via 4-aminobutyrate" EXACT [MetaCyc:GLUDEG-I-PWY synonym: "glutamate degradation via GABA" EXACT [MetaCyc:GLUDEG-I-PWY] xref: MetaCyc:GLUDEG-I-PWY intersection_of: GO:0009056 ! catabolic process -intersection_of: has_output CHEBI:30031 ! succinate(2-) +intersection_of: has_primary_output CHEBI:30031 ! succinate(2-) intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-) relationship: has_part GO:0003867 ! 4-aminobutyrate transaminase activity relationship: has_part GO:0004351 ! glutamate decarboxylase activity @@ -64863,6 +64863,7 @@ synonym: "reduced nicotinamide adenine dinucleotide regeneration" EXACT [] intersection_of: GO:0008152 ! metabolic process intersection_of: has_output CHEBI:57945 ! NADH(2-) intersection_of: has_primary_input CHEBI:57540 ! NAD(1-) +intersection_of: has_primary_output CHEBI:57945 ! NADH(2-) [Term] id: GO:0006738 @@ -64914,8 +64915,8 @@ synonym: "reduced nicotinamide adenine dinucleotide phosphate regeneration" EXAC is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0006739 ! NADP metabolic process intersection_of: GO:0008152 ! metabolic process -intersection_of: has_output CHEBI:57783 ! NADPH(4-) intersection_of: has_primary_input CHEBI:58349 ! NADP(3-) +intersection_of: has_primary_output CHEBI:57783 ! NADPH(4-) [Term] id: GO:0006741 @@ -73341,7 +73342,7 @@ xref: Wikipedia:Coagulation is_a: GO:0007599 ! hemostasis is_a: GO:0050817 ! coagulation intersection_of: GO:0050817 ! coagulation -intersection_of: has_output UBERON:0010210 ! blood clot +intersection_of: has_primary_output UBERON:0010210 ! blood clot relationship: part_of GO:0042060 ! wound healing [Term] @@ -80586,7 +80587,7 @@ synonym: "pyrimidine salvage" RELATED [] is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:39447 ! pyrimidines +intersection_of: has_primary_output CHEBI:39447 ! pyrimidines [Term] id: GO:0008656 @@ -86121,10 +86122,10 @@ xref: MetaCyc:OXIDATIVEPENT-PWY is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: ends_with GO:0004616 ! phosphogluconate dehydrogenase (decarboxylating) activity -intersection_of: has_output CHEBI:57783 ! NADPH(4-) intersection_of: has_part GO:0004341 ! gluconolactonase activity intersection_of: has_primary_input CHEBI:14314 ! D-glucose 6-phosphate intersection_of: has_primary_input CHEBI:58349 ! NADP(3-) +intersection_of: has_primary_output CHEBI:57783 ! NADPH(4-) intersection_of: starts_with GO:0004345 ! glucose-6-phosphate dehydrogenase activity relationship: part_of GO:0006098 ! pentose-phosphate shunt @@ -86140,13 +86141,13 @@ xref: MetaCyc:NONOXIPENT-PWY xref: MetaCyc:P21-PWY is_a: GO:0006091 ! generation of precursor metabolites and energy intersection_of: GO:0008152 ! metabolic process -intersection_of: has_output CHEBI:58027 ! glyceraldehyde 3-phosphate(2-) -intersection_of: has_output CHEBI:78697 ! D-fructose 6-phosphate intersection_of: has_part GO:0004750 ! D-ribulose-phosphate 3-epimerase activity intersection_of: has_part GO:0004751 ! ribose-5-phosphate isomerase activity intersection_of: has_part GO:0004801 ! transaldolase activity intersection_of: has_part GO:0004802 ! transketolase activity intersection_of: has_primary_input CHEBI:78679 ! D-ribose 5-phosphate +intersection_of: has_primary_output CHEBI:58027 ! glyceraldehyde 3-phosphate(2-) +intersection_of: has_primary_output CHEBI:78697 ! D-fructose 6-phosphate relationship: part_of GO:0006098 ! pentose-phosphate shunt [Term] @@ -88510,8 +88511,8 @@ is_a: GO:0061678 ! Entner-Doudoroff pathway intersection_of: GO:0061678 ! Entner-Doudoroff pathway intersection_of: ends_with GO:0008675 ! 2-dehydro-3-deoxy-phosphogluconate aldolase activity intersection_of: has_intermediate CHEBI:58759 ! 6-phosphonatooxy-D-gluconate -intersection_of: has_output CHEBI:15361 ! pyruvate -intersection_of: has_output CHEBI:58027 ! glyceraldehyde 3-phosphate(2-) +intersection_of: has_primary_output CHEBI:15361 ! pyruvate +intersection_of: has_primary_output CHEBI:58027 ! glyceraldehyde 3-phosphate(2-) intersection_of: has_part GO:0004456 ! phosphogluconate dehydratase activity [Term] @@ -90396,7 +90397,7 @@ xref: MetaCyc:PLPSAL-PWY is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:597326 ! pyridoxal 5'-phosphate(2-) +intersection_of: has_primary_output CHEBI:597326 ! pyridoxal 5'-phosphate(2-) [Term] id: GO:0009444 @@ -97319,7 +97320,7 @@ def: "The pathway by which pyrimidine bases or pyrimidine ribonucleosides from p is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0032262 ! pyrimidine nucleotide salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:26446 ! pyrimidine ribonucleotide +intersection_of: has_primary_output CHEBI:26446 ! pyrimidine ribonucleotide [Term] id: GO:0010139 @@ -97330,7 +97331,7 @@ xref: MetaCyc:PWY-7199 is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0032262 ! pyrimidine nucleotide salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:26436 ! pyrimidine 2'-deoxyribonucleotide +intersection_of: has_primary_output CHEBI:26436 ! pyrimidine 2'-deoxyribonucleotide [Term] id: GO:0010140 @@ -118693,7 +118694,7 @@ synonym: "endosome to synaptic vesicle budding" RELATED [GOC:mah] synonym: "synaptic vesicle budding involved in synaptic vesicle exocytosis" EXACT [GOC:mah] is_a: GO:0006900 ! vesicle budding from membrane is_a: GO:0016192 ! vesicle-mediated transport -relationship: has_output GO:0008021 ! synaptic vesicle +relationship: has_primary_output GO:0008021 ! synaptic vesicle relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome relationship: part_of GO:0099532 ! synaptic vesicle endosomal processing @@ -119096,7 +119097,7 @@ synonym: "iron-sulfur cluster biosynthesis" RELATED [] synonym: "iron-sulphur cluster assembly" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process intersection_of: GO:0022607 ! cellular component assembly -intersection_of: has_output CHEBI:30408 ! iron-sulfur cluster +intersection_of: has_primary_output CHEBI:30408 ! iron-sulfur cluster [Term] id: GO:0016227 @@ -121634,7 +121635,7 @@ name: peroxisome membrane biogenesis namespace: biological_process def: "The process in which a peroxisome membrane is synthesized, aggregates, and bonds together." [GOC:mah] intersection_of: GO:0044085 ! cellular component biogenesis -intersection_of: has_output GO:0005778 ! peroxisomal membrane +intersection_of: has_primary_output GO:0005778 ! peroxisomal membrane relationship: part_of GO:0007031 ! peroxisome organization [Term] @@ -127054,7 +127055,7 @@ synonym: "nucleolus assembly" NARROW [GOC:mah] synonym: "nucleolus biogenesis" EXACT [] is_a: GO:0007000 ! nucleolus organization intersection_of: GO:0044085 ! cellular component biogenesis -intersection_of: has_output GO:0005730 ! nucleolus +intersection_of: has_primary_output GO:0005730 ! nucleolus [Term] id: GO:0017128 @@ -131474,7 +131475,7 @@ subset: gocheck_do_not_annotate xref: RESID:AA0235 is_a: GO:0017185 ! peptidyl-lysine hydroxylation intersection_of: GO:0017185 ! peptidyl-lysine hydroxylation -intersection_of: has_output CHEBI:141496 ! 4-hydroxy-L-lysine(1+) +intersection_of: has_primary_output CHEBI:141496 ! 4-hydroxy-L-lysine(1+) [Term] id: GO:0018397 @@ -131513,7 +131514,7 @@ subset: gocheck_do_not_annotate xref: RESID:AA0029 is_a: GO:0019511 ! peptidyl-proline hydroxylation intersection_of: GO:0019511 ! peptidyl-proline hydroxylation -intersection_of: has_output CHEBI:20056 ! 3-hydroxy-L-proline +intersection_of: has_primary_output CHEBI:20056 ! 3-hydroxy-L-proline [Term] id: GO:0018401 @@ -131525,7 +131526,7 @@ subset: gocheck_do_not_annotate xref: RESID:AA0030 is_a: GO:0019511 ! peptidyl-proline hydroxylation intersection_of: GO:0019511 ! peptidyl-proline hydroxylation -intersection_of: has_output CHEBI:58419 ! 4-hydroxy-L-proline zwitterion +intersection_of: has_primary_output CHEBI:58419 ! 4-hydroxy-L-proline zwitterion [Term] id: GO:0018402 @@ -141511,7 +141512,7 @@ xref: MetaCyc:PYRIDNUCSAL-PWY is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process is_a: GO:0019365 ! pyridine nucleotide salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:25534 ! nicotinic acid nucleotide +intersection_of: has_primary_output CHEBI:25534 ! nicotinic acid nucleotide [Term] id: GO:0019359 @@ -141592,7 +141593,7 @@ synonym: "pyridine nucleotide cycling" EXACT [] is_a: GO:0019363 ! pyridine nucleotide biosynthetic process is_a: GO:0043173 ! nucleotide salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:36980 ! pyridine nucleotide +intersection_of: has_primary_output CHEBI:36980 ! pyridine nucleotide [Term] id: GO:0019367 @@ -142652,7 +142653,7 @@ synonym: "glutamine breakdown to fumarate, using glutaminase" EXACT [] synonym: "glutamine degradation to fumarate, using glutaminase" NARROW [] xref: MetaCyc:GLUTAMINDEG-PWY intersection_of: GO:0009056 ! catabolic process -intersection_of: has_output CHEBI:29806 ! fumarate(2-) +intersection_of: has_primary_output CHEBI:29806 ! fumarate(2-) intersection_of: has_part GO:0004359 ! glutaminase activity intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-) @@ -142986,7 +142987,7 @@ synonym: "proline cycling" EXACT [] is_a: GO:0006561 ! proline biosynthetic process is_a: GO:0043102 ! amino acid salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:32871 ! prolinate +intersection_of: has_primary_output CHEBI:32871 ! prolinate [Term] id: GO:0019493 @@ -144226,7 +144227,7 @@ xref: UM-BBD_pathwayID:tol is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0019600 ! toluene oxidation intersection_of: GO:0019600 ! toluene oxidation -intersection_of: has_output CHEBI:18135 ! catechol +intersection_of: has_primary_output CHEBI:18135 ! catechol [Term] id: GO:0019605 @@ -144733,11 +144734,11 @@ xref: Wikipedia:Butanediol_fermentation is_a: GO:0019660 ! glycolytic fermentation intersection_of: GO:0019660 ! glycolytic fermentation intersection_of: ends_with GO:0000721 ! (R,R)-butanediol dehydrogenase activity -intersection_of: has_output CHEBI:62064 ! butane-2,3-diol intersection_of: has_part GO:0003984 ! acetolactate synthase activity intersection_of: has_part GO:0047605 ! acetolactate decarboxylase activity intersection_of: has_part GO:0052587 ! diacetyl reductase ((R)-acetoin forming) activity intersection_of: has_primary_input CHEBI:17234 ! glucose +intersection_of: has_primary_output CHEBI:62064 ! butane-2,3-diol [Term] id: GO:0019651 @@ -144808,8 +144809,8 @@ synonym: "glucose catabolic process to ethanol" EXACT [GOC:dph] synonym: "glucose fermentation to ethanol" EXACT [] xref: Wikipedia:Ethanol_fermentation intersection_of: GO:0019660 ! glycolytic fermentation -intersection_of: has_output CHEBI:16236 ! ethanol intersection_of: has_primary_input CHEBI:17234 ! glucose +intersection_of: has_primary_output CHEBI:16236 ! ethanol intersection_of: starts_with GO:0061615 ! glycolytic process through fructose-6-phosphate property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23284" xsd:anyURI @@ -144843,7 +144844,7 @@ is_a: GO:0019541 ! propionate metabolic process is_a: GO:0019660 ! glycolytic fermentation is_a: GO:0042867 ! pyruvate catabolic process intersection_of: GO:0019660 ! glycolytic fermentation -intersection_of: has_output CHEBI:17272 ! propionate +intersection_of: has_primary_output CHEBI:17272 ! propionate intersection_of: has_part GO:0043821 ! propionyl-CoA:succinate CoA-transferase activity intersection_of: has_part GO:0047154 ! methylmalonyl-CoA carboxytransferase activity intersection_of: starts_with GO:0061633 ! transport-coupled glycolytic process through glucose-6-phosphate @@ -144858,8 +144859,8 @@ synonym: "glucose catabolic process to lactate and acetate" BROAD [] xref: MetaCyc:P124-PWY is_a: GO:0019662 ! non-glycolytic fermentation intersection_of: GO:0009056 ! catabolic process -intersection_of: has_output CHEBI:24996 ! lactate -intersection_of: has_output CHEBI:30089 ! acetate +intersection_of: has_primary_output CHEBI:24996 ! lactate +intersection_of: has_primary_output CHEBI:30089 ! acetate intersection_of: has_primary_input CHEBI:17234 ! glucose [Term] @@ -144922,13 +144923,13 @@ synonym: "glucose fermentation to mixed acids" EXACT [] xref: Wikipedia:Mixed_acid_fermentation is_a: GO:0019660 ! glycolytic fermentation intersection_of: GO:0019660 ! glycolytic fermentation -intersection_of: has_output CHEBI:15740 ! formate -intersection_of: has_output CHEBI:16236 ! ethanol -intersection_of: has_output CHEBI:16810 ! 2-oxoglutarate(2-) -intersection_of: has_output CHEBI:24996 ! lactate -intersection_of: has_output CHEBI:30031 ! succinate(2-) -intersection_of: has_output CHEBI:30089 ! acetate intersection_of: has_primary_input CHEBI:17234 ! glucose +intersection_of: has_primary_output CHEBI:15740 ! formate +intersection_of: has_primary_output CHEBI:16236 ! ethanol +intersection_of: has_primary_output CHEBI:16810 ! 2-oxoglutarate(2-) +intersection_of: has_primary_output CHEBI:24996 ! lactate +intersection_of: has_primary_output CHEBI:30031 ! succinate(2-) +intersection_of: has_primary_output CHEBI:30089 ! acetate [Term] id: GO:0019665 @@ -167752,7 +167753,7 @@ synonym: "metal-sulfur cluster assembly" EXACT [GOC:pr] synonym: "metallo-sulfur cluster biosynthesis" RELATED [] synonym: "metallo-sulphur cluster assembly" EXACT [] intersection_of: GO:0022607 ! cellular component assembly -intersection_of: has_output CHEBI:25214 ! metal-sulfur cluster +intersection_of: has_primary_output CHEBI:25214 ! metal-sulfur cluster [Term] id: GO:0031164 @@ -172965,7 +172966,7 @@ namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division." [GOC:jl] is_a: GO:1902410 ! mitotic cytokinetic process intersection_of: GO:0044085 ! cellular component biogenesis -intersection_of: has_output GO:0000936 ! primary cell septum +intersection_of: has_primary_output GO:0000936 ! primary cell septum relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis relationship: part_of GO:0140278 ! mitotic division septum assembly @@ -178717,7 +178718,7 @@ is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0008655 ! pyrimidine-containing compound salvage is_a: GO:0043173 ! nucleotide salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:26441 ! pyrimidine nucleotide +intersection_of: has_primary_output CHEBI:26441 ! pyrimidine nucleotide [Term] id: GO:0032263 @@ -190069,7 +190070,7 @@ xref: MetaCyc:PWY-5107 is_a: GO:0033520 ! phytol biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:17327 ! phytol +intersection_of: has_primary_output CHEBI:17327 ! phytol [Term] id: GO:0033308 @@ -201921,7 +201922,7 @@ def: "Any process that generates nicotinamide adenine dinucleotide (NAD) from de synonym: "NAD salvage pathway" EXACT [] is_a: GO:0009435 ! NAD biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:13389 ! NAD +intersection_of: has_primary_output CHEBI:13389 ! NAD property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21577" xsd:anyURI [Term] @@ -220868,7 +220869,7 @@ xref: MetaCyc:PWY-6898 is_a: GO:0008655 ! pyrimidine-containing compound salvage is_a: GO:0009228 ! thiamine biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:18385 ! thiamine(1+) +intersection_of: has_primary_output CHEBI:18385 ! thiamine(1+) created_by: bf creation_date: 2012-03-29T10:31:05Z @@ -221176,7 +221177,7 @@ synonym: "dTMP biosynthesis via salvage pathway" RELATED [GOC:yaf, PMID:5387459] is_a: GO:0006231 ! dTMP biosynthetic process is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:63528 ! dTMP(2-) +intersection_of: has_primary_output CHEBI:63528 ! dTMP(2-) created_by: bf creation_date: 2012-04-20T10:33:28Z @@ -223979,7 +223980,7 @@ xref: KEGG_REACTION:R00351 xref: MetaCyc:CITSYN-RXN xref: RHEA:16845 is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer -relationship: has_output CHEBI:16947 ! citrate(3-) +relationship: has_primary_output CHEBI:16947 ! citrate(3-) created_by: bf creation_date: 2013-09-30T16:21:50Z @@ -234107,7 +234108,7 @@ xref: MetaCyc:PWY-6 is_a: GO:0042350 ! GDP-L-fucose biosynthetic process is_a: GO:0043173 ! nucleotide salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:57984 ! GDP-L-fucose(2-) +intersection_of: has_primary_output CHEBI:57984 ! GDP-L-fucose(2-) [Term] id: GO:0042353 @@ -236019,7 +236020,7 @@ def: "A cellular process that results in the biosynthesis of constituent macromo synonym: "cell wall assembly" NARROW [] is_a: GO:0071554 ! cell wall organization or biogenesis intersection_of: GO:0044085 ! cellular component biogenesis -intersection_of: has_output GO:0005618 ! cell wall +intersection_of: has_primary_output GO:0005618 ! cell wall [Term] id: GO:0042547 @@ -241450,7 +241451,7 @@ synonym: "purine base salvage" EXACT [GOC:go_curators] is_a: GO:0009113 ! purine nucleobase biosynthetic process is_a: GO:0043101 ! purine-containing compound salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:26386 ! purine nucleobase +intersection_of: has_primary_output CHEBI:26386 ! purine nucleobase [Term] id: GO:0043097 @@ -241461,7 +241462,7 @@ is_a: GO:0008655 ! pyrimidine-containing compound salvage is_a: GO:0043174 ! nucleoside salvage is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:26440 ! pyrimidine nucleoside +intersection_of: has_primary_output CHEBI:26440 ! pyrimidine nucleoside [Term] id: GO:0043098 @@ -241472,7 +241473,7 @@ is_a: GO:0043101 ! purine-containing compound salvage is_a: GO:0043174 ! nucleoside salvage is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:60173 ! purine deoxyribonucleoside +intersection_of: has_primary_output CHEBI:60173 ! purine deoxyribonucleoside [Term] id: GO:0043099 @@ -241482,7 +241483,7 @@ def: "Any process that generates a pyrimidine deoxyribonucleoside from derivativ is_a: GO:0043097 ! pyrimidine nucleoside salvage is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:19255 ! pyrimidine 2'-deoxyribonucleoside +intersection_of: has_primary_output CHEBI:19255 ! pyrimidine 2'-deoxyribonucleoside [Term] id: GO:0043100 @@ -241492,7 +241493,7 @@ def: "Any process that generates pyrimidine nucleobases, 1,3-diazine organic nit synonym: "pyrimidine base salvage" EXACT [GOC:go_curators] is_a: GO:0008655 ! pyrimidine-containing compound salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:26432 ! pyrimidine nucleobase +intersection_of: has_primary_output CHEBI:26432 ! pyrimidine nucleobase [Term] id: GO:0043101 @@ -241505,7 +241506,7 @@ is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage is_a: GO:0072522 ! purine-containing compound biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:26401 ! purines +intersection_of: has_primary_output CHEBI:26401 ! purines [Term] id: GO:0043102 @@ -241515,7 +241516,7 @@ def: "Any process which produces an amino acid from derivatives of it, without d is_a: GO:0008652 ! amino acid biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:37022 ! amino-acid anion +intersection_of: has_primary_output CHEBI:37022 ! amino-acid anion [Term] id: GO:0043103 @@ -241527,7 +241528,7 @@ synonym: "guanine, xanthine and their nucleoside salvage" NARROW [] is_a: GO:0043096 ! purine nucleobase salvage is_a: GO:0046101 ! hypoxanthine biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:17368 ! hypoxanthine +intersection_of: has_primary_output CHEBI:17368 ! hypoxanthine [Term] id: GO:0043104 @@ -242127,7 +242128,7 @@ synonym: "cell wall formation" BROAD [] synonym: "cell wall synthesis" BROAD [] is_a: GO:0009273 ! peptidoglycan-based cell wall biogenesis intersection_of: GO:0044085 ! cellular component biogenesis -intersection_of: has_output GO:0009276 ! Gram-negative-bacterium-type cell wall +intersection_of: has_primary_output GO:0009276 ! Gram-negative-bacterium-type cell wall [Term] id: GO:0043165 @@ -242216,7 +242217,7 @@ xref: Wikipedia:Nucleotide_salvage is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:36976 ! nucleotide +intersection_of: has_primary_output CHEBI:36976 ! nucleotide [Term] id: GO:0043174 @@ -242226,7 +242227,7 @@ def: "Any process which produces a nucleotide, a nucleobase linked to either bet is_a: GO:0009163 ! nucleoside biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:33838 ! nucleoside +intersection_of: has_primary_output CHEBI:33838 ! nucleoside [Term] id: GO:0043175 @@ -251729,7 +251730,7 @@ name: membrane biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl] intersection_of: GO:0044085 ! cellular component biogenesis -intersection_of: has_output GO:0016020 ! membrane +intersection_of: has_primary_output GO:0016020 ! membrane [Term] id: GO:0044092 @@ -252846,7 +252847,7 @@ synonym: "UMP biosynthetic process via nucleoside salvage pathway" EXACT [] is_a: GO:0006222 ! UMP biosynthetic process is_a: GO:0010138 ! pyrimidine ribonucleotide salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:57865 ! uridine 5'-monophosphate(2-) +intersection_of: has_primary_output CHEBI:57865 ! uridine 5'-monophosphate(2-) created_by: jl creation_date: 2009-10-21T11:32:33Z @@ -252905,7 +252906,7 @@ synonym: "cytidine 5'-triphosphate salvage" EXACT [] is_a: GO:0006241 ! CTP biosynthetic process is_a: GO:0010138 ! pyrimidine ribonucleotide salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:37563 ! CTP(4-) +intersection_of: has_primary_output CHEBI:37563 ! CTP(4-) created_by: jl creation_date: 2009-10-22T03:24:04Z @@ -256620,7 +256621,7 @@ def: "The incorporation of two iron atoms and two sulfur atoms into an iron-sulf synonym: "2Fe-2S cluster assembly" EXACT [] synonym: "[2Fe-2S] cluster biosynthetic process" RELATED [] intersection_of: GO:0022607 ! cellular component assembly -intersection_of: has_output CHEBI:49601 ! Fe2S2 iron-sulfur cluster +intersection_of: has_primary_output CHEBI:49601 ! Fe2S2 iron-sulfur cluster created_by: jl creation_date: 2012-04-18T03:06:30Z @@ -256633,7 +256634,7 @@ synonym: "4Fe-4S cluster assembly" EXACT [] synonym: "[4Fe-4S] cluster biosynthetic process" RELATED [] is_a: GO:0016226 ! iron-sulfur cluster assembly intersection_of: GO:0022607 ! cellular component assembly -intersection_of: has_output CHEBI:64607 ! Fe4S4 iron-sulfur cluster +intersection_of: has_primary_output CHEBI:64607 ! Fe4S4 iron-sulfur cluster created_by: jl creation_date: 2012-04-18T03:19:23Z @@ -258973,7 +258974,7 @@ xref: Wikipedia:Fermentative_hydrogen_production is_a: GO:0006113 ! fermentation is_a: GO:1902422 ! hydrogen biosynthetic process intersection_of: GO:0006113 ! fermentation -intersection_of: has_output CHEBI:18276 ! dihydrogen +intersection_of: has_primary_output CHEBI:18276 ! dihydrogen created_by: jl creation_date: 2013-09-18T14:09:47Z @@ -262809,7 +262810,7 @@ name: rhabdomere membrane biogenesis namespace: biological_process def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane." [GOC:jl] intersection_of: GO:0044085 ! cellular component biogenesis -intersection_of: has_output GO:0033583 ! rhabdomere membrane +intersection_of: has_primary_output GO:0033583 ! rhabdomere membrane relationship: part_of GO:0042052 ! rhabdomere development [Term] @@ -273453,7 +273454,7 @@ synonym: "anthocyanin metabolism" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:0042440 ! pigment metabolic process intersection_of: GO:0008152 ! metabolic process -intersection_of: has_output CHEBI:38697 ! anthocyanin +intersection_of: has_primary_output CHEBI:38697 ! anthocyanin [Term] id: GO:0046284 @@ -297061,7 +297062,7 @@ def: "The evagination of the Golgi membrane, resulting in formation of a vesicle synonym: "dictyosome vesicle budding" NARROW [] synonym: "Golgi-derived vesicle budding" EXACT [] intersection_of: GO:0006900 ! vesicle budding from membrane -intersection_of: has_output GO:0005798 ! Golgi-associated vesicle +intersection_of: has_primary_output GO:0005798 ! Golgi-associated vesicle intersection_of: occurs_in GO:0000139 ! Golgi membrane relationship: part_of GO:0048193 ! Golgi vesicle transport @@ -335906,7 +335907,7 @@ namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any chitobiose, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine." [GOC:curators] is_a: GO:0052782 ! amino disaccharide catabolic process intersection_of: GO:0009056 ! catabolic process -intersection_of: has_output CHEBI:50674 ! chitobioses +intersection_of: has_primary_output CHEBI:50674 ! chitobioses created_by: ai creation_date: 2011-10-03T08:54:17Z @@ -356131,9 +356132,9 @@ synonym: "glycerol to DHAP metabolic process" EXACT [GOC:dph] synonym: "glycerol to dihydroxyacetone phosphate metabolic process" EXACT [GOC:dph] is_a: GO:0006071 ! glycerol metabolic process intersection_of: GO:0006071 ! glycerol metabolic process -intersection_of: has_output CHEBI:57642 ! glycerone phosphate(2-) intersection_of: has_part GO:0047952 ! glycerol-3-phosphate dehydrogenase [NAD(P)+] activity intersection_of: has_primary_input CHEBI:17754 ! glycerol +intersection_of: has_primary_output CHEBI:57642 ! glycerone phosphate(2-) intersection_of: starts_with GO:0004370 ! glycerol kinase activity created_by: dph creation_date: 2014-04-03T13:26:21Z @@ -356147,8 +356148,8 @@ synonym: "mannose metabolism to fructose-6-phosphate" EXACT [GOC:dph] is_a: GO:0006013 ! mannose metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: ends_with GO:0004476 ! mannose-6-phosphate isomerase activity -intersection_of: has_output CHEBI:57579 ! D-fructose 6-phosphate(2-) intersection_of: has_primary_input CHEBI:37684 ! mannose +intersection_of: has_primary_output CHEBI:57579 ! D-fructose 6-phosphate(2-) intersection_of: starts_with GO:0019158 ! mannokinase activity created_by: dph creation_date: 2014-04-03T13:38:50Z @@ -356284,10 +356285,10 @@ xref: Reactome:R-HSA-70171 "Glycolysis, Homo sapiens" xref: Wikipedia:Glycolysis is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate intersection_of: GO:0061620 ! glycolytic process through glucose-6-phosphate -intersection_of: has_output CHEBI:57945 ! NADH(2-) intersection_of: has_part GO:0004365 ! glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity intersection_of: has_primary_input CHEBI:17234 ! glucose intersection_of: has_primary_input CHEBI:57540 ! NAD(1-) +intersection_of: has_primary_output CHEBI:57945 ! NADH(2-) intersection_of: starts_with GO:0004340 ! glucokinase activity created_by: dph creation_date: 2014-04-14T09:21:54Z @@ -356911,7 +356912,7 @@ namespace: biological_process def: "A cellular carbohydrate catabolic process that converts a carbohydrate to pyruvate and either glyceraldehyde or glyceraldehyde-3 phosphate by dehydration and aldol cleavage via a gluconate or 6-phosphogluconate intermediate." [GOC:dph, PMID:12921536] xref: MetaCyc:Entner-Doudoroff-Pathways is_a: GO:0016052 ! carbohydrate catabolic process -relationship: has_output CHEBI:15361 ! pyruvate +relationship: has_primary_output CHEBI:15361 ! pyruvate created_by: dph creation_date: 2015-01-16T15:28:25Z @@ -356924,7 +356925,7 @@ synonym: "gluconate pathway" RELATED [] is_a: GO:0061678 ! Entner-Doudoroff pathway intersection_of: GO:0061678 ! Entner-Doudoroff pathway intersection_of: has_intermediate CHEBI:18391 ! D-gluconate -intersection_of: has_output CHEBI:15361 ! pyruvate +intersection_of: has_primary_output CHEBI:15361 ! pyruvate intersection_of: has_part GO:0047929 ! gluconate dehydratase activity intersection_of: has_part GO:0047935 ! glucose 1-dehydrogenase (NADP+) activity created_by: dph @@ -356939,7 +356940,7 @@ xref: MetaCyc:NPGLUCAT-PWY is_a: GO:0061679 ! Entner-Doudoroff pathway through gluconate intersection_of: GO:0061679 ! Entner-Doudoroff pathway through gluconate intersection_of: ends_with GO:0061677 ! 2-dehydro-3-deoxy-D-gluconate aldolase activity -intersection_of: has_output CHEBI:17378 ! D-glyceraldehyde +intersection_of: has_primary_output CHEBI:17378 ! D-glyceraldehyde created_by: dph creation_date: 2015-01-22T08:51:31Z @@ -356952,7 +356953,7 @@ xref: MetaCyc:PWY-2221 is_a: GO:0061679 ! Entner-Doudoroff pathway through gluconate intersection_of: GO:0061679 ! Entner-Doudoroff pathway through gluconate intersection_of: ends_with GO:0008675 ! 2-dehydro-3-deoxy-phosphogluconate aldolase activity -intersection_of: has_output CHEBI:58027 ! glyceraldehyde 3-phosphate(2-) +intersection_of: has_primary_output CHEBI:58027 ! glyceraldehyde 3-phosphate(2-) intersection_of: has_part GO:0008673 ! 2-dehydro-3-deoxygluconokinase activity created_by: dph creation_date: 2015-01-22T08:55:22Z @@ -357470,9 +357471,9 @@ is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:1902777 ! 6-sulfoquinovose(1-) catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: ends_with GO:0004743 ! pyruvate kinase activity -intersection_of: has_output CHEBI:15361 ! pyruvate -intersection_of: has_output CHEBI:30616 ! ATP(4-) -intersection_of: has_output CHEBI:57945 ! NADH(2-) +intersection_of: has_primary_output CHEBI:15361 ! pyruvate +intersection_of: has_primary_output CHEBI:30616 ! ATP(4-) +intersection_of: has_primary_output CHEBI:57945 ! NADH(2-) intersection_of: has_part GO:0004365 ! glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity intersection_of: has_part GO:0004618 ! phosphoglycerate kinase activity intersection_of: has_part GO:0004619 ! phosphoglycerate mutase activity @@ -360372,7 +360373,7 @@ synonym: "cichorine formation" EXACT [] synonym: "cichorine synthesis" EXACT [] is_a: GO:0044550 ! secondary metabolite biosynthetic process intersection_of: GO:0009058 ! biosynthetic process -intersection_of: has_output CHEBI:64977 ! cichorine +intersection_of: has_primary_output CHEBI:64977 ! cichorine created_by: dph creation_date: 2018-04-19T16:22:09Z @@ -363899,7 +363900,7 @@ name: synaptic vesicle budding namespace: biological_process def: "Evagination of a membrane to form a synaptic vesicle." [GOC:mah] intersection_of: GO:0006900 ! vesicle budding from membrane -intersection_of: has_output GO:0008021 ! synaptic vesicle +intersection_of: has_primary_output GO:0008021 ! synaptic vesicle relationship: part_of GO:0048489 ! synaptic vesicle transport [Term] @@ -373207,8 +373208,8 @@ synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenation" E synonym: "reduced nicotinamide adenine dinucleotide phosphate oxidation" EXACT [GOC:mah] is_a: GO:0006739 ! NADP metabolic process intersection_of: GO:0008152 ! metabolic process -intersection_of: has_output CHEBI:58349 ! NADP(3-) intersection_of: has_primary_input CHEBI:57783 ! NADPH(4-) +intersection_of: has_primary_output CHEBI:58349 ! NADP(3-) created_by: mah creation_date: 2009-11-03T12:02:15Z @@ -376235,7 +376236,7 @@ def: "Any process that generates L-methionine from derivatives of it, without de is_a: GO:0043102 ! amino acid salvage is_a: GO:0071265 ! L-methionine biosynthetic process intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:57844 ! L-methionine zwitterion +intersection_of: has_primary_output CHEBI:57844 ! L-methionine zwitterion created_by: mah creation_date: 2009-12-09T04:36:49Z @@ -425756,7 +425757,7 @@ namespace: biological_process def: "The process in which a nuclear membrane is synthesized, aggregates, and bonds together." [GOC:vw] is_a: GO:0044091 ! membrane biogenesis intersection_of: GO:0044085 ! cellular component biogenesis -intersection_of: has_output GO:0031965 ! nuclear membrane +intersection_of: has_primary_output GO:0031965 ! nuclear membrane relationship: part_of GO:0071763 ! nuclear membrane organization [Term] @@ -442739,7 +442740,7 @@ name: steroid hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:krc, GOC:nln] intersection_of: GO:0006694 ! steroid biosynthetic process -intersection_of: has_output CHEBI:26764 ! steroid hormone +intersection_of: has_primary_output CHEBI:26764 ! steroid hormone property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/16000" xsd:anyURI created_by: krc creation_date: 2019-05-20T22:34:00Z @@ -457949,7 +457950,7 @@ def: "The process in which an endoplasmic reticulum membrane is synthesized, agg synonym: "ER membrane biogenesis" EXACT [] is_a: GO:0044085 ! cellular component biogenesis intersection_of: GO:0044085 ! cellular component biogenesis -intersection_of: has_output GO:0005789 ! endoplasmic reticulum membrane +intersection_of: has_primary_output GO:0005789 ! endoplasmic reticulum membrane relationship: part_of GO:0090158 ! endoplasmic reticulum membrane organization property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22720" xsd:anyURI created_by: rynl @@ -569207,7 +569208,7 @@ namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a secondary cell septum following nuclear division." [PMID:22891259] is_a: GO:1902410 ! mitotic cytokinetic process intersection_of: GO:0044085 ! cellular component biogenesis -intersection_of: has_output GO:0051077 ! secondary cell septum +intersection_of: has_primary_output GO:0051077 ! secondary cell septum relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis relationship: part_of GO:0140278 ! mitotic division septum assembly created_by: mah @@ -569753,7 +569754,7 @@ def: "Any process which produces queuosine from derivatives of it, without de no is_a: GO:0008616 ! queuosine biosynthetic process is_a: GO:0043174 ! nucleoside salvage intersection_of: GO:0043094 ! cellular metabolic compound salvage -intersection_of: has_output CHEBI:60193 ! queuosine +intersection_of: has_primary_output CHEBI:60193 ! queuosine created_by: pr creation_date: 2014-06-10T14:56:12Z @@ -569976,7 +569977,7 @@ namespace: biological_process def: "The release of snoRNA from pre-rRNA." [GOC:rb, PMID:16908538] comment: An example of this process is yeast HAS1 from PMID:16908538, inferred from mutant phenotype assay. is_a: GO:0006364 ! rRNA processing -relationship: has_output SO:0000275 ! snoRNA +relationship: has_primary_output SO:0000275 ! snoRNA created_by: rb creation_date: 2014-07-11T21:43:27Z @@ -576163,7 +576164,7 @@ namespace: biological_process def: "The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming." [PMID:27257257] is_a: GO:0046034 ! ATP metabolic process intersection_of: GO:0008152 ! metabolic process -intersection_of: has_output CHEBI:30616 ! ATP(4-) +intersection_of: has_primary_output CHEBI:30616 ! ATP(4-) intersection_of: has_primary_input_or_output CHEBI:61151 ! poly-ADP-D-ribose created_by: sp creation_date: 2016-06-16T09:41:35Z