index.html



<!DOCTYPE html>
<html>
<head>

<meta name="viewport" content="width=device-width, initial-scale=1">
<meta charset="utf-8" />
<title>VAT-ISMB-2018</title>

<style type="text/css">
    /*!
*
* Twitter Bootstrap
*
*/
/*!
 * Bootstrap v3.3.7 (http://getbootstrap.com)
 * Copyright 2011-2016 Twitter, Inc.
 * Licensed under MIT (https://github.com/twbs/bootstrap/blob/master/LICENSE)
 */
/*! normalize.css v3.0.3 | MIT License | github.com/necolas/normalize.css */
html {
  font-family: sans-serif;
  -ms-text-size-adjust: 100%;
  -webkit-text-size-adjust: 100%;
}
body {
  margin: 0;
}
article,
aside,
details,
figcaption,
figure,
footer,
header,
hgroup,
main,
menu,
nav,
section,
summary {
  display: block;
}
audio,
canvas,
progress,
video {
  display: inline-block;
  vertical-align: baseline;
}
audio:not([controls]) {
  display: none;
  height: 0;
}
[hidden],
template {
  display: none;
}
a {
  background-color: transparent;
}
a:active,
a:hover {
  outline: 0;
}
abbr[title] {
  border-bottom: 1px dotted;
}
b,
strong {
  font-weight: bold;
}
dfn {
  font-style: italic;
}
h1 {
  font-size: 2em;
  margin: 0.67em 0;
}
mark {
  background: #ff0;
  color: #000;
}
small {
  font-size: 80%;
}
sub,
sup {
  font-size: 75%;
  line-height: 0;
  position: relative;
  vertical-align: baseline;
}
sup {
  top: -0.5em;
}
sub {
  bottom: -0.25em;
}
img {
  border: 0;
}
svg:not(:root) {
  overflow: hidden;
}
figure {
  margin: 1em 40px;
}
hr {
  box-sizing: content-box;
  height: 0;
}
pre {
  overflow: auto;
}
code,
kbd,
pre,
samp {
  font-family: monospace, monospace;
  font-size: 1em;
}
button,
input,
optgroup,
select,
textarea {
  color: inherit;
  font: inherit;
  margin: 0;
}
button {
  overflow: visible;
}
button,
select {
  text-transform: none;
}
button,
html input[type="button"],
input[type="reset"],
input[type="submit"] {
  -webkit-appearance: button;
  cursor: pointer;
}
button[disabled],
html input[disabled] {
  cursor: default;
}
button::-moz-focus-inner,
input::-moz-focus-inner {
  border: 0;
  padding: 0;
}
input {
  line-height: normal;
}
input[type="checkbox"],
input[type="radio"] {
  box-sizing: border-box;
  padding: 0;
}
input[type="number"]::-webkit-inner-spin-button,
input[type="number"]::-webkit-outer-spin-button {
  height: auto;
}
input[type="search"] {
  -webkit-appearance: textfield;
  box-sizing: content-box;
}
input[type="search"]::-webkit-search-cancel-button,
input[type="search"]::-webkit-search-decoration {
  -webkit-appearance: none;
}
fieldset {
  border: 1px solid #c0c0c0;
  margin: 0 2px;
  padding: 0.35em 0.625em 0.75em;
}
legend {
  border: 0;
  padding: 0;
}
textarea {
  overflow: auto;
}
optgroup {
  font-weight: bold;
}
table {
  border-collapse: collapse;
  border-spacing: 0;
}
td,
th {
  padding: 0;
}
/*! Source: https://github.com/h5bp/html5-boilerplate/blob/master/src/css/main.css */
@media print {
  *,
  *:before,
  *:after {
    background: transparent !important;
    color: #000 !important;
    box-shadow: none !important;
    text-shadow: none !important;
  }
  a,
  a:visited {
    text-decoration: underline;
  }
  a[href]:after {
    content: " (" attr(href) ")";
  }
  abbr[title]:after {
    content: " (" attr(title) ")";
  }
  a[href^="#"]:after,
  a[href^="javascript:"]:after {
    content: "";
  }
  pre,
  blockquote {
    border: 1px solid #999;
    page-break-inside: avoid;
  }
  thead {
    display: table-header-group;
  }
  tr,
  img {
    page-break-inside: avoid;
  }
  img {
    max-width: 100% !important;
  }
  p,
  h2,
  h3 {
    orphans: 3;
    widows: 3;
  }
  h2,
  h3 {
    page-break-after: avoid;
  }
  .navbar {
    display: none;
  }
  .btn > .caret,
  .dropup > .btn > .caret {
    border-top-color: #000 !important;
  }
  .label {
    border: 1px solid #000;
  }
  .table {
    border-collapse: collapse !important;
  }
  .table td,
  .table th {
    background-color: #fff !important;
  }
  .table-bordered th,
  .table-bordered td {
    border: 1px solid #ddd !important;
  }
}
@font-face {
  font-family: 'Glyphicons Halflings';
  src: url('../components/bootstrap/fonts/glyphicons-halflings-regular.eot');
  src: url('../components/bootstrap/fonts/glyphicons-halflings-regular.eot?#iefix') format('embedded-opentype'), url('../components/bootstrap/fonts/glyphicons-halflings-regular.woff2') format('woff2'), url('../components/bootstrap/fonts/glyphicons-halflings-regular.woff') format('woff'), url('../components/bootstrap/fonts/glyphicons-halflings-regular.ttf') format('truetype'), url('../components/bootstrap/fonts/glyphicons-halflings-regular.svg#glyphicons_halflingsregular') format('svg');
}
.glyphicon {
  position: relative;
  top: 1px;
  display: inline-block;
  font-family: 'Glyphicons Halflings';
  font-style: normal;
  font-weight: normal;
  line-height: 1;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}
.glyphicon-asterisk:before {
  content: "\002a";
}
.glyphicon-plus:before {
  content: "\002b";
}
.glyphicon-euro:before,
.glyphicon-eur:before {
  content: "\20ac";
}
.glyphicon-minus:before {
  content: "\2212";
}
.glyphicon-cloud:before {
  content: "\2601";
}
.glyphicon-envelope:before {
  content: "\2709";
}
.glyphicon-pencil:before {
  content: "\270f";
}
.glyphicon-glass:before {
  content: "\e001";
}
.glyphicon-music:before {
  content: "\e002";
}
.glyphicon-search:before {
  content: "\e003";
}
.glyphicon-heart:before {
  content: "\e005";
}
.glyphicon-star:before {
  content: "\e006";
}
.glyphicon-star-empty:before {
  content: "\e007";
}
.glyphicon-user:before {
  content: "\e008";
}
.glyphicon-film:before {
  content: "\e009";
}
.glyphicon-th-large:before {
  content: "\e010";
}
.glyphicon-th:before {
  content: "\e011";
}
.glyphicon-th-list:before {
  content: "\e012";
}
.glyphicon-ok:before {
  content: "\e013";
}
.glyphicon-remove:before {
  content: "\e014";
}
.glyphicon-zoom-in:before {
  content: "\e015";
}
.glyphicon-zoom-out:before {
  content: "\e016";
}
.glyphicon-off:before {
  content: "\e017";
}
.glyphicon-signal:before {
  content: "\e018";
}
.glyphicon-cog:before {
  content: "\e019";
}
.glyphicon-trash:before {
  content: "\e020";
}
.glyphicon-home:before {
  content: "\e021";
}
.glyphicon-file:before {
  content: "\e022";
}
.glyphicon-time:before {
  content: "\e023";
}
.glyphicon-road:before {
  content: "\e024";
}
.glyphicon-download-alt:before {
  content: "\e025";
}
.glyphicon-download:before {
  content: "\e026";
}
.glyphicon-upload:before {
  content: "\e027";
}
.glyphicon-inbox:before {
  content: "\e028";
}
.glyphicon-play-circle:before {
  content: "\e029";
}
.glyphicon-repeat:before {
  content: "\e030";
}
.glyphicon-refresh:before {
  content: "\e031";
}
.glyphicon-list-alt:before {
  content: "\e032";
}
.glyphicon-lock:before {
  content: "\e033";
}
.glyphicon-flag:before {
  content: "\e034";
}
.glyphicon-headphones:before {
  content: "\e035";
}
.glyphicon-volume-off:before {
  content: "\e036";
}
.glyphicon-volume-down:before {
  content: "\e037";
}
.glyphicon-volume-up:before {
  content: "\e038";
}
.glyphicon-qrcode:before {
  content: "\e039";
}
.glyphicon-barcode:before {
  content: "\e040";
}
.glyphicon-tag:before {
  content: "\e041";
}
.glyphicon-tags:before {
  content: "\e042";
}
.glyphicon-book:before {
  content: "\e043";
}
.glyphicon-bookmark:before {
  content: "\e044";
}
.glyphicon-print:before {
  content: "\e045";
}
.glyphicon-camera:before {
  content: "\e046";
}
.glyphicon-font:before {
  content: "\e047";
}
.glyphicon-bold:before {
  content: "\e048";
}
.glyphicon-italic:before {
  content: "\e049";
}
.glyphicon-text-height:before {
  content: "\e050";
}
.glyphicon-text-width:before {
  content: "\e051";
}
.glyphicon-align-left:before {
  content: "\e052";
}
.glyphicon-align-center:before {
  content: "\e053";
}
.glyphicon-align-right:before {
  content: "\e054";
}
.glyphicon-align-justify:before {
  content: "\e055";
}
.glyphicon-list:before {
  content: "\e056";
}
.glyphicon-indent-left:before {
  content: "\e057";
}
.glyphicon-indent-right:before {
  content: "\e058";
}
.glyphicon-facetime-video:before {
  content: "\e059";
}
.glyphicon-picture:before {
  content: "\e060";
}
.glyphicon-map-marker:before {
  content: "\e062";
}
.glyphicon-adjust:before {
  content: "\e063";
}
.glyphicon-tint:before {
  content: "\e064";
}
.glyphicon-edit:before {
  content: "\e065";
}
.glyphicon-share:before {
  content: "\e066";
}
.glyphicon-check:before {
  content: "\e067";
}
.glyphicon-move:before {
  content: "\e068";
}
.glyphicon-step-backward:before {
  content: "\e069";
}
.glyphicon-fast-backward:before {
  content: "\e070";
}
.glyphicon-backward:before {
  content: "\e071";
}
.glyphicon-play:before {
  content: "\e072";
}
.glyphicon-pause:before {
  content: "\e073";
}
.glyphicon-stop:before {
  content: "\e074";
}
.glyphicon-forward:before {
  content: "\e075";
}
.glyphicon-fast-forward:before {
  content: "\e076";
}
.glyphicon-step-forward:before {
  content: "\e077";
}
.glyphicon-eject:before {
  content: "\e078";
}
.glyphicon-chevron-left:before {
  content: "\e079";
}
.glyphicon-chevron-right:before {
  content: "\e080";
}
.glyphicon-plus-sign:before {
  content: "\e081";
}
.glyphicon-minus-sign:before {
  content: "\e082";
}
.glyphicon-remove-sign:before {
  content: "\e083";
}
.glyphicon-ok-sign:before {
  content: "\e084";
}
.glyphicon-question-sign:before {
  content: "\e085";
}
.glyphicon-info-sign:before {
  content: "\e086";
}
.glyphicon-screenshot:before {
  content: "\e087";
}
.glyphicon-remove-circle:before {
  content: "\e088";
}
.glyphicon-ok-circle:before {
  content: "\e089";
}
.glyphicon-ban-circle:before {
  content: "\e090";
}
.glyphicon-arrow-left:before {
  content: "\e091";
}
.glyphicon-arrow-right:before {
  content: "\e092";
}
.glyphicon-arrow-up:before {
  content: "\e093";
}
.glyphicon-arrow-down:before {
  content: "\e094";
}
.glyphicon-share-alt:before {
  content: "\e095";
}
.glyphicon-resize-full:before {
  content: "\e096";
}
.glyphicon-resize-small:before {
  content: "\e097";
}
.glyphicon-exclamation-sign:before {
  content: "\e101";
}
.glyphicon-gift:before {
  content: "\e102";
}
.glyphicon-leaf:before {
  content: "\e103";
}
.glyphicon-fire:before {
  content: "\e104";
}
.glyphicon-eye-open:before {
  content: "\e105";
}
.glyphicon-eye-close:before {
  content: "\e106";
}
.glyphicon-warning-sign:before {
  content: "\e107";
}
.glyphicon-plane:before {
  content: "\e108";
}
.glyphicon-calendar:before {
  content: "\e109";
}
.glyphicon-random:before {
  content: "\e110";
}
.glyphicon-comment:before {
  content: "\e111";
}
.glyphicon-magnet:before {
  content: "\e112";
}
.glyphicon-chevron-up:before {
  content: "\e113";
}
.glyphicon-chevron-down:before {
  content: "\e114";
}
.glyphicon-retweet:before {
  content: "\e115";
}
.glyphicon-shopping-cart:before {
  content: "\e116";
}
.glyphicon-folder-close:before {
  content: "\e117";
}
.glyphicon-folder-open:before {
  content: "\e118";
}
.glyphicon-resize-vertical:before {
  content: "\e119";
}
.glyphicon-resize-horizontal:before {
  content: "\e120";
}
.glyphicon-hdd:before {
  content: "\e121";
}
.glyphicon-bullhorn:before {
  content: "\e122";
}
.glyphicon-bell:before {
  content: "\e123";
}
.glyphicon-certificate:before {
  content: "\e124";
}
.glyphicon-thumbs-up:before {
  content: "\e125";
}
.glyphicon-thumbs-down:before {
  content: "\e126";
}
.glyphicon-hand-right:before {
  content: "\e127";
}
.glyphicon-hand-left:before {
  content: "\e128";
}
.glyphicon-hand-up:before {
  content: "\e129";
}
.glyphicon-hand-down:before {
  content: "\e130";
}
.glyphicon-circle-arrow-right:before {
  content: "\e131";
}
.glyphicon-circle-arrow-left:before {
  content: "\e132";
}
.glyphicon-circle-arrow-up:before {
  content: "\e133";
}
.glyphicon-circle-arrow-down:before {
  content: "\e134";
}
.glyphicon-globe:before {
  content: "\e135";
}
.glyphicon-wrench:before {
  content: "\e136";
}
.glyphicon-tasks:before {
  content: "\e137";
}
.glyphicon-filter:before {
  content: "\e138";
}
.glyphicon-briefcase:before {
  content: "\e139";
}
.glyphicon-fullscreen:before {
  content: "\e140";
}
.glyphicon-dashboard:before {
  content: "\e141";
}
.glyphicon-paperclip:before {
  content: "\e142";
}
.glyphicon-heart-empty:before {
  content: "\e143";
}
.glyphicon-link:before {
  content: "\e144";
}
.glyphicon-phone:before {
  content: "\e145";
}
.glyphicon-pushpin:before {
  content: "\e146";
}
.glyphicon-usd:before {
  content: "\e148";
}
.glyphicon-gbp:before {
  content: "\e149";
}
.glyphicon-sort:before {
  content: "\e150";
}
.glyphicon-sort-by-alphabet:before {
  content: "\e151";
}
.glyphicon-sort-by-alphabet-alt:before {
  content: "\e152";
}
.glyphicon-sort-by-order:before {
  content: "\e153";
}
.glyphicon-sort-by-order-alt:before {
  content: "\e154";
}
.glyphicon-sort-by-attributes:before {
  content: "\e155";
}
.glyphicon-sort-by-attributes-alt:before {
  content: "\e156";
}
.glyphicon-unchecked:before {
  content: "\e157";
}
.glyphicon-expand:before {
  content: "\e158";
}
.glyphicon-collapse-down:before {
  content: "\e159";
}
.glyphicon-collapse-up:before {
  content: "\e160";
}
.glyphicon-log-in:before {
  content: "\e161";
}
.glyphicon-flash:before {
  content: "\e162";
}
.glyphicon-log-out:before {
  content: "\e163";
}
.glyphicon-new-window:before {
  content: "\e164";
}
.glyphicon-record:before {
  content: "\e165";
}
.glyphicon-save:before {
  content: "\e166";
}
.glyphicon-open:before {
  content: "\e167";
}
.glyphicon-saved:before {
  content: "\e168";
}
.glyphicon-import:before {
  content: "\e169";
}
.glyphicon-export:before {
  content: "\e170";
}
.glyphicon-send:before {
  content: "\e171";
}
.glyphicon-floppy-disk:before {
  content: "\e172";
}
.glyphicon-floppy-saved:before {
  content: "\e173";
}
.glyphicon-floppy-remove:before {
  content: "\e174";
}
.glyphicon-floppy-save:before {
  content: "\e175";
}
.glyphicon-floppy-open:before {
  content: "\e176";
}
.glyphicon-credit-card:before {
  content: "\e177";
}
.glyphicon-transfer:before {
  content: "\e178";
}
.glyphicon-cutlery:before {
  content: "\e179";
}
.glyphicon-header:before {
  content: "\e180";
}
.glyphicon-compressed:before {
  content: "\e181";
}
.glyphicon-earphone:before {
  content: "\e182";
}
.glyphicon-phone-alt:before {
  content: "\e183";
}
.glyphicon-tower:before {
  content: "\e184";
}
.glyphicon-stats:before {
  content: "\e185";
}
.glyphicon-sd-video:before {
  content: "\e186";
}
.glyphicon-hd-video:before {
  content: "\e187";
}
.glyphicon-subtitles:before {
  content: "\e188";
}
.glyphicon-sound-stereo:before {
  content: "\e189";
}
.glyphicon-sound-dolby:before {
  content: "\e190";
}
.glyphicon-sound-5-1:before {
  content: "\e191";
}
.glyphicon-sound-6-1:before {
  content: "\e192";
}
.glyphicon-sound-7-1:before {
  content: "\e193";
}
.glyphicon-copyright-mark:before {
  content: "\e194";
}
.glyphicon-registration-mark:before {
  content: "\e195";
}
.glyphicon-cloud-download:before {
  content: "\e197";
}
.glyphicon-cloud-upload:before {
  content: "\e198";
}
.glyphicon-tree-conifer:before {
  content: "\e199";
}
.glyphicon-tree-deciduous:before {
  content: "\e200";
}
.glyphicon-cd:before {
  content: "\e201";
}
.glyphicon-save-file:before {
  content: "\e202";
}
.glyphicon-open-file:before {
  content: "\e203";
}
.glyphicon-level-up:before {
  content: "\e204";
}
.glyphicon-copy:before {
  content: "\e205";
}
.glyphicon-paste:before {
  content: "\e206";
}
.glyphicon-alert:before {
  content: "\e209";
}
.glyphicon-equalizer:before {
  content: "\e210";
}
.glyphicon-king:before {
  content: "\e211";
}
.glyphicon-queen:before {
  content: "\e212";
}
.glyphicon-pawn:before {
  content: "\e213";
}
.glyphicon-bishop:before {
  content: "\e214";
}
.glyphicon-knight:before {
  content: "\e215";
}
.glyphicon-baby-formula:before {
  content: "\e216";
}
.glyphicon-tent:before {
  content: "\26fa";
}
.glyphicon-blackboard:before {
  content: "\e218";
}
.glyphicon-bed:before {
  content: "\e219";
}
.glyphicon-apple:before {
  content: "\f8ff";
}
.glyphicon-erase:before {
  content: "\e221";
}
.glyphicon-hourglass:before {
  content: "\231b";
}
.glyphicon-lamp:before {
  content: "\e223";
}
.glyphicon-duplicate:before {
  content: "\e224";
}
.glyphicon-piggy-bank:before {
  content: "\e225";
}
.glyphicon-scissors:before {
  content: "\e226";
}
.glyphicon-bitcoin:before {
  content: "\e227";
}
.glyphicon-btc:before {
  content: "\e227";
}
.glyphicon-xbt:before {
  content: "\e227";
}
.glyphicon-yen:before {
  content: "\00a5";
}
.glyphicon-jpy:before {
  content: "\00a5";
}
.glyphicon-ruble:before {
  content: "\20bd";
}
.glyphicon-rub:before {
  content: "\20bd";
}
.glyphicon-scale:before {
  content: "\e230";
}
.glyphicon-ice-lolly:before {
  content: "\e231";
}
.glyphicon-ice-lolly-tasted:before {
  content: "\e232";
}
.glyphicon-education:before {
  content: "\e233";
}
.glyphicon-option-horizontal:before {
  content: "\e234";
}
.glyphicon-option-vertical:before {
  content: "\e235";
}
.glyphicon-menu-hamburger:before {
  content: "\e236";
}
.glyphicon-modal-window:before {
  content: "\e237";
}
.glyphicon-oil:before {
  content: "\e238";
}
.glyphicon-grain:before {
  content: "\e239";
}
.glyphicon-sunglasses:before {
  content: "\e240";
}
.glyphicon-text-size:before {
  content: "\e241";
}
.glyphicon-text-color:before {
  content: "\e242";
}
.glyphicon-text-background:before {
  content: "\e243";
}
.glyphicon-object-align-top:before {
  content: "\e244";
}
.glyphicon-object-align-bottom:before {
  content: "\e245";
}
.glyphicon-object-align-horizontal:before {
  content: "\e246";
}
.glyphicon-object-align-left:before {
  content: "\e247";
}
.glyphicon-object-align-vertical:before {
  content: "\e248";
}
.glyphicon-object-align-right:before {
  content: "\e249";
}
.glyphicon-triangle-right:before {
  content: "\e250";
}
.glyphicon-triangle-left:before {
  content: "\e251";
}
.glyphicon-triangle-bottom:before {
  content: "\e252";
}
.glyphicon-triangle-top:before {
  content: "\e253";
}
.glyphicon-console:before {
  content: "\e254";
}
.glyphicon-superscript:before {
  content: "\e255";
}
.glyphicon-subscript:before {
  content: "\e256";
}
.glyphicon-menu-left:before {
  content: "\e257";
}
.glyphicon-menu-right:before {
  content: "\e258";
}
.glyphicon-menu-down:before {
  content: "\e259";
}
.glyphicon-menu-up:before {
  content: "\e260";
}
* {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
*:before,
*:after {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
html {
  font-size: 10px;
  -webkit-tap-highlight-color: rgba(0, 0, 0, 0);
}
body {
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-size: 13px;
  line-height: 1.42857143;
  color: #000;
  background-color: #fff;
}
input,
button,
select,
textarea {
  font-family: inherit;
  font-size: inherit;
  line-height: inherit;
}
a {
  color: #337ab7;
  text-decoration: none;
}
a:hover,
a:focus {
  color: #23527c;
  text-decoration: underline;
}
a:focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
figure {
  margin: 0;
}
img {
  vertical-align: middle;
}
.img-responsive,
.thumbnail > img,
.thumbnail a > img,
.carousel-inner > .item > img,
.carousel-inner > .item > a > img {
  display: block;
  max-width: 100%;
  height: auto;
}
.img-rounded {
  border-radius: 3px;
}
.img-thumbnail {
  padding: 4px;
  line-height: 1.42857143;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 2px;
  -webkit-transition: all 0.2s ease-in-out;
  -o-transition: all 0.2s ease-in-out;
  transition: all 0.2s ease-in-out;
  display: inline-block;
  max-width: 100%;
  height: auto;
}
.img-circle {
  border-radius: 50%;
}
hr {
  margin-top: 18px;
  margin-bottom: 18px;
  border: 0;
  border-top: 1px solid #eeeeee;
}
.sr-only {
  position: absolute;
  width: 1px;
  height: 1px;
  margin: -1px;
  padding: 0;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
  border: 0;
}
.sr-only-focusable:active,
.sr-only-focusable:focus {
  position: static;
  width: auto;
  height: auto;
  margin: 0;
  overflow: visible;
  clip: auto;
}
[role="button"] {
  cursor: pointer;
}
h1,
h2,
h3,
h4,
h5,
h6,
.h1,
.h2,
.h3,
.h4,
.h5,
.h6 {
  font-family: inherit;
  font-weight: 500;
  line-height: 1.1;
  color: inherit;
}
h1 small,
h2 small,
h3 small,
h4 small,
h5 small,
h6 small,
.h1 small,
.h2 small,
.h3 small,
.h4 small,
.h5 small,
.h6 small,
h1 .small,
h2 .small,
h3 .small,
h4 .small,
h5 .small,
h6 .small,
.h1 .small,
.h2 .small,
.h3 .small,
.h4 .small,
.h5 .small,
.h6 .small {
  font-weight: normal;
  line-height: 1;
  color: #777777;
}
h1,
.h1,
h2,
.h2,
h3,
.h3 {
  margin-top: 18px;
  margin-bottom: 9px;
}
h1 small,
.h1 small,
h2 small,
.h2 small,
h3 small,
.h3 small,
h1 .small,
.h1 .small,
h2 .small,
.h2 .small,
h3 .small,
.h3 .small {
  font-size: 65%;
}
h4,
.h4,
h5,
.h5,
h6,
.h6 {
  margin-top: 9px;
  margin-bottom: 9px;
}
h4 small,
.h4 small,
h5 small,
.h5 small,
h6 small,
.h6 small,
h4 .small,
.h4 .small,
h5 .small,
.h5 .small,
h6 .small,
.h6 .small {
  font-size: 75%;
}
h1,
.h1 {
  font-size: 33px;
}
h2,
.h2 {
  font-size: 27px;
}
h3,
.h3 {
  font-size: 23px;
}
h4,
.h4 {
  font-size: 17px;
}
h5,
.h5 {
  font-size: 13px;
}
h6,
.h6 {
  font-size: 12px;
}
p {
  margin: 0 0 9px;
}
.lead {
  margin-bottom: 18px;
  font-size: 14px;
  font-weight: 300;
  line-height: 1.4;
}
@media (min-width: 768px) {
  .lead {
    font-size: 19.5px;
  }
}
small,
.small {
  font-size: 92%;
}
mark,
.mark {
  background-color: #fcf8e3;
  padding: .2em;
}
.text-left {
  text-align: left;
}
.text-right {
  text-align: right;
}
.text-center {
  text-align: center;
}
.text-justify {
  text-align: justify;
}
.text-nowrap {
  white-space: nowrap;
}
.text-lowercase {
  text-transform: lowercase;
}
.text-uppercase {
  text-transform: uppercase;
}
.text-capitalize {
  text-transform: capitalize;
}
.text-muted {
  color: #777777;
}
.text-primary {
  color: #337ab7;
}
a.text-primary:hover,
a.text-primary:focus {
  color: #286090;
}
.text-success {
  color: #3c763d;
}
a.text-success:hover,
a.text-success:focus {
  color: #2b542c;
}
.text-info {
  color: #31708f;
}
a.text-info:hover,
a.text-info:focus {
  color: #245269;
}
.text-warning {
  color: #8a6d3b;
}
a.text-warning:hover,
a.text-warning:focus {
  color: #66512c;
}
.text-danger {
  color: #a94442;
}
a.text-danger:hover,
a.text-danger:focus {
  color: #843534;
}
.bg-primary {
  color: #fff;
  background-color: #337ab7;
}
a.bg-primary:hover,
a.bg-primary:focus {
  background-color: #286090;
}
.bg-success {
  background-color: #dff0d8;
}
a.bg-success:hover,
a.bg-success:focus {
  background-color: #c1e2b3;
}
.bg-info {
  background-color: #d9edf7;
}
a.bg-info:hover,
a.bg-info:focus {
  background-color: #afd9ee;
}
.bg-warning {
  background-color: #fcf8e3;
}
a.bg-warning:hover,
a.bg-warning:focus {
  background-color: #f7ecb5;
}
.bg-danger {
  background-color: #f2dede;
}
a.bg-danger:hover,
a.bg-danger:focus {
  background-color: #e4b9b9;
}
.page-header {
  padding-bottom: 8px;
  margin: 36px 0 18px;
  border-bottom: 1px solid #eeeeee;
}
ul,
ol {
  margin-top: 0;
  margin-bottom: 9px;
}
ul ul,
ol ul,
ul ol,
ol ol {
  margin-bottom: 0;
}
.list-unstyled {
  padding-left: 0;
  list-style: none;
}
.list-inline {
  padding-left: 0;
  list-style: none;
  margin-left: -5px;
}
.list-inline > li {
  display: inline-block;
  padding-left: 5px;
  padding-right: 5px;
}
dl {
  margin-top: 0;
  margin-bottom: 18px;
}
dt,
dd {
  line-height: 1.42857143;
}
dt {
  font-weight: bold;
}
dd {
  margin-left: 0;
}
@media (min-width: 541px) {
  .dl-horizontal dt {
    float: left;
    width: 160px;
    clear: left;
    text-align: right;
    overflow: hidden;
    text-overflow: ellipsis;
    white-space: nowrap;
  }
  .dl-horizontal dd {
    margin-left: 180px;
  }
}
abbr[title],
abbr[data-original-title] {
  cursor: help;
  border-bottom: 1px dotted #777777;
}
.initialism {
  font-size: 90%;
  text-transform: uppercase;
}
blockquote {
  padding: 9px 18px;
  margin: 0 0 18px;
  font-size: inherit;
  border-left: 5px solid #eeeeee;
}
blockquote p:last-child,
blockquote ul:last-child,
blockquote ol:last-child {
  margin-bottom: 0;
}
blockquote footer,
blockquote small,
blockquote .small {
  display: block;
  font-size: 80%;
  line-height: 1.42857143;
  color: #777777;
}
blockquote footer:before,
blockquote small:before,
blockquote .small:before {
  content: '\2014 \00A0';
}
.blockquote-reverse,
blockquote.pull-right {
  padding-right: 15px;
  padding-left: 0;
  border-right: 5px solid #eeeeee;
  border-left: 0;
  text-align: right;
}
.blockquote-reverse footer:before,
blockquote.pull-right footer:before,
.blockquote-reverse small:before,
blockquote.pull-right small:before,
.blockquote-reverse .small:before,
blockquote.pull-right .small:before {
  content: '';
}
.blockquote-reverse footer:after,
blockquote.pull-right footer:after,
.blockquote-reverse small:after,
blockquote.pull-right small:after,
.blockquote-reverse .small:after,
blockquote.pull-right .small:after {
  content: '\00A0 \2014';
}
address {
  margin-bottom: 18px;
  font-style: normal;
  line-height: 1.42857143;
}
code,
kbd,
pre,
samp {
  font-family: monospace;
}
code {
  padding: 2px 4px;
  font-size: 90%;
  color: #c7254e;
  background-color: #f9f2f4;
  border-radius: 2px;
}
kbd {
  padding: 2px 4px;
  font-size: 90%;
  color: #888;
  background-color: transparent;
  border-radius: 1px;
  box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.25);
}
kbd kbd {
  padding: 0;
  font-size: 100%;
  font-weight: bold;
  box-shadow: none;
}
pre {
  display: block;
  padding: 8.5px;
  margin: 0 0 9px;
  font-size: 12px;
  line-height: 1.42857143;
  word-break: break-all;
  word-wrap: break-word;
  color: #333333;
  background-color: #f5f5f5;
  border: 1px solid #ccc;
  border-radius: 2px;
}
pre code {
  padding: 0;
  font-size: inherit;
  color: inherit;
  white-space: pre-wrap;
  background-color: transparent;
  border-radius: 0;
}
.pre-scrollable {
  max-height: 340px;
  overflow-y: scroll;
}
.container {
  margin-right: auto;
  margin-left: auto;
  padding-left: 0px;
  padding-right: 0px;
}
@media (min-width: 768px) {
  .container {
    width: 768px;
  }
}
@media (min-width: 992px) {
  .container {
    width: 940px;
  }
}
@media (min-width: 1200px) {
  .container {
    width: 1140px;
  }
}
.container-fluid {
  margin-right: auto;
  margin-left: auto;
  padding-left: 0px;
  padding-right: 0px;
}
.row {
  margin-left: 0px;
  margin-right: 0px;
}
.col-xs-1, .col-sm-1, .col-md-1, .col-lg-1, .col-xs-2, .col-sm-2, .col-md-2, .col-lg-2, .col-xs-3, .col-sm-3, .col-md-3, .col-lg-3, .col-xs-4, .col-sm-4, .col-md-4, .col-lg-4, .col-xs-5, .col-sm-5, .col-md-5, .col-lg-5, .col-xs-6, .col-sm-6, .col-md-6, .col-lg-6, .col-xs-7, .col-sm-7, .col-md-7, .col-lg-7, .col-xs-8, .col-sm-8, .col-md-8, .col-lg-8, .col-xs-9, .col-sm-9, .col-md-9, .col-lg-9, .col-xs-10, .col-sm-10, .col-md-10, .col-lg-10, .col-xs-11, .col-sm-11, .col-md-11, .col-lg-11, .col-xs-12, .col-sm-12, .col-md-12, .col-lg-12 {
  position: relative;
  min-height: 1px;
  padding-left: 0px;
  padding-right: 0px;
}
.col-xs-1, .col-xs-2, .col-xs-3, .col-xs-4, .col-xs-5, .col-xs-6, .col-xs-7, .col-xs-8, .col-xs-9, .col-xs-10, .col-xs-11, .col-xs-12 {
  float: left;
}
.col-xs-12 {
  width: 100%;
}
.col-xs-11 {
  width: 91.66666667%;
}
.col-xs-10 {
  width: 83.33333333%;
}
.col-xs-9 {
  width: 75%;
}
.col-xs-8 {
  width: 66.66666667%;
}
.col-xs-7 {
  width: 58.33333333%;
}
.col-xs-6 {
  width: 50%;
}
.col-xs-5 {
  width: 41.66666667%;
}
.col-xs-4 {
  width: 33.33333333%;
}
.col-xs-3 {
  width: 25%;
}
.col-xs-2 {
  width: 16.66666667%;
}
.col-xs-1 {
  width: 8.33333333%;
}
.col-xs-pull-12 {
  right: 100%;
}
.col-xs-pull-11 {
  right: 91.66666667%;
}
.col-xs-pull-10 {
  right: 83.33333333%;
}
.col-xs-pull-9 {
  right: 75%;
}
.col-xs-pull-8 {
  right: 66.66666667%;
}
.col-xs-pull-7 {
  right: 58.33333333%;
}
.col-xs-pull-6 {
  right: 50%;
}
.col-xs-pull-5 {
  right: 41.66666667%;
}
.col-xs-pull-4 {
  right: 33.33333333%;
}
.col-xs-pull-3 {
  right: 25%;
}
.col-xs-pull-2 {
  right: 16.66666667%;
}
.col-xs-pull-1 {
  right: 8.33333333%;
}
.col-xs-pull-0 {
  right: auto;
}
.col-xs-push-12 {
  left: 100%;
}
.col-xs-push-11 {
  left: 91.66666667%;
}
.col-xs-push-10 {
  left: 83.33333333%;
}
.col-xs-push-9 {
  left: 75%;
}
.col-xs-push-8 {
  left: 66.66666667%;
}
.col-xs-push-7 {
  left: 58.33333333%;
}
.col-xs-push-6 {
  left: 50%;
}
.col-xs-push-5 {
  left: 41.66666667%;
}
.col-xs-push-4 {
  left: 33.33333333%;
}
.col-xs-push-3 {
  left: 25%;
}
.col-xs-push-2 {
  left: 16.66666667%;
}
.col-xs-push-1 {
  left: 8.33333333%;
}
.col-xs-push-0 {
  left: auto;
}
.col-xs-offset-12 {
  margin-left: 100%;
}
.col-xs-offset-11 {
  margin-left: 91.66666667%;
}
.col-xs-offset-10 {
  margin-left: 83.33333333%;
}
.col-xs-offset-9 {
  margin-left: 75%;
}
.col-xs-offset-8 {
  margin-left: 66.66666667%;
}
.col-xs-offset-7 {
  margin-left: 58.33333333%;
}
.col-xs-offset-6 {
  margin-left: 50%;
}
.col-xs-offset-5 {
  margin-left: 41.66666667%;
}
.col-xs-offset-4 {
  margin-left: 33.33333333%;
}
.col-xs-offset-3 {
  margin-left: 25%;
}
.col-xs-offset-2 {
  margin-left: 16.66666667%;
}
.col-xs-offset-1 {
  margin-left: 8.33333333%;
}
.col-xs-offset-0 {
  margin-left: 0%;
}
@media (min-width: 768px) {
  .col-sm-1, .col-sm-2, .col-sm-3, .col-sm-4, .col-sm-5, .col-sm-6, .col-sm-7, .col-sm-8, .col-sm-9, .col-sm-10, .col-sm-11, .col-sm-12 {
    float: left;
  }
  .col-sm-12 {
    width: 100%;
  }
  .col-sm-11 {
    width: 91.66666667%;
  }
  .col-sm-10 {
    width: 83.33333333%;
  }
  .col-sm-9 {
    width: 75%;
  }
  .col-sm-8 {
    width: 66.66666667%;
  }
  .col-sm-7 {
    width: 58.33333333%;
  }
  .col-sm-6 {
    width: 50%;
  }
  .col-sm-5 {
    width: 41.66666667%;
  }
  .col-sm-4 {
    width: 33.33333333%;
  }
  .col-sm-3 {
    width: 25%;
  }
  .col-sm-2 {
    width: 16.66666667%;
  }
  .col-sm-1 {
    width: 8.33333333%;
  }
  .col-sm-pull-12 {
    right: 100%;
  }
  .col-sm-pull-11 {
    right: 91.66666667%;
  }
  .col-sm-pull-10 {
    right: 83.33333333%;
  }
  .col-sm-pull-9 {
    right: 75%;
  }
  .col-sm-pull-8 {
    right: 66.66666667%;
  }
  .col-sm-pull-7 {
    right: 58.33333333%;
  }
  .col-sm-pull-6 {
    right: 50%;
  }
  .col-sm-pull-5 {
    right: 41.66666667%;
  }
  .col-sm-pull-4 {
    right: 33.33333333%;
  }
  .col-sm-pull-3 {
    right: 25%;
  }
  .col-sm-pull-2 {
    right: 16.66666667%;
  }
  .col-sm-pull-1 {
    right: 8.33333333%;
  }
  .col-sm-pull-0 {
    right: auto;
  }
  .col-sm-push-12 {
    left: 100%;
  }
  .col-sm-push-11 {
    left: 91.66666667%;
  }
  .col-sm-push-10 {
    left: 83.33333333%;
  }
  .col-sm-push-9 {
    left: 75%;
  }
  .col-sm-push-8 {
    left: 66.66666667%;
  }
  .col-sm-push-7 {
    left: 58.33333333%;
  }
  .col-sm-push-6 {
    left: 50%;
  }
  .col-sm-push-5 {
    left: 41.66666667%;
  }
  .col-sm-push-4 {
    left: 33.33333333%;
  }
  .col-sm-push-3 {
    left: 25%;
  }
  .col-sm-push-2 {
    left: 16.66666667%;
  }
  .col-sm-push-1 {
    left: 8.33333333%;
  }
  .col-sm-push-0 {
    left: auto;
  }
  .col-sm-offset-12 {
    margin-left: 100%;
  }
  .col-sm-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-sm-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-sm-offset-9 {
    margin-left: 75%;
  }
  .col-sm-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-sm-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-sm-offset-6 {
    margin-left: 50%;
  }
  .col-sm-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-sm-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-sm-offset-3 {
    margin-left: 25%;
  }
  .col-sm-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-sm-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-sm-offset-0 {
    margin-left: 0%;
  }
}
@media (min-width: 992px) {
  .col-md-1, .col-md-2, .col-md-3, .col-md-4, .col-md-5, .col-md-6, .col-md-7, .col-md-8, .col-md-9, .col-md-10, .col-md-11, .col-md-12 {
    float: left;
  }
  .col-md-12 {
    width: 100%;
  }
  .col-md-11 {
    width: 91.66666667%;
  }
  .col-md-10 {
    width: 83.33333333%;
  }
  .col-md-9 {
    width: 75%;
  }
  .col-md-8 {
    width: 66.66666667%;
  }
  .col-md-7 {
    width: 58.33333333%;
  }
  .col-md-6 {
    width: 50%;
  }
  .col-md-5 {
    width: 41.66666667%;
  }
  .col-md-4 {
    width: 33.33333333%;
  }
  .col-md-3 {
    width: 25%;
  }
  .col-md-2 {
    width: 16.66666667%;
  }
  .col-md-1 {
    width: 8.33333333%;
  }
  .col-md-pull-12 {
    right: 100%;
  }
  .col-md-pull-11 {
    right: 91.66666667%;
  }
  .col-md-pull-10 {
    right: 83.33333333%;
  }
  .col-md-pull-9 {
    right: 75%;
  }
  .col-md-pull-8 {
    right: 66.66666667%;
  }
  .col-md-pull-7 {
    right: 58.33333333%;
  }
  .col-md-pull-6 {
    right: 50%;
  }
  .col-md-pull-5 {
    right: 41.66666667%;
  }
  .col-md-pull-4 {
    right: 33.33333333%;
  }
  .col-md-pull-3 {
    right: 25%;
  }
  .col-md-pull-2 {
    right: 16.66666667%;
  }
  .col-md-pull-1 {
    right: 8.33333333%;
  }
  .col-md-pull-0 {
    right: auto;
  }
  .col-md-push-12 {
    left: 100%;
  }
  .col-md-push-11 {
    left: 91.66666667%;
  }
  .col-md-push-10 {
    left: 83.33333333%;
  }
  .col-md-push-9 {
    left: 75%;
  }
  .col-md-push-8 {
    left: 66.66666667%;
  }
  .col-md-push-7 {
    left: 58.33333333%;
  }
  .col-md-push-6 {
    left: 50%;
  }
  .col-md-push-5 {
    left: 41.66666667%;
  }
  .col-md-push-4 {
    left: 33.33333333%;
  }
  .col-md-push-3 {
    left: 25%;
  }
  .col-md-push-2 {
    left: 16.66666667%;
  }
  .col-md-push-1 {
    left: 8.33333333%;
  }
  .col-md-push-0 {
    left: auto;
  }
  .col-md-offset-12 {
    margin-left: 100%;
  }
  .col-md-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-md-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-md-offset-9 {
    margin-left: 75%;
  }
  .col-md-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-md-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-md-offset-6 {
    margin-left: 50%;
  }
  .col-md-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-md-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-md-offset-3 {
    margin-left: 25%;
  }
  .col-md-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-md-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-md-offset-0 {
    margin-left: 0%;
  }
}
@media (min-width: 1200px) {
  .col-lg-1, .col-lg-2, .col-lg-3, .col-lg-4, .col-lg-5, .col-lg-6, .col-lg-7, .col-lg-8, .col-lg-9, .col-lg-10, .col-lg-11, .col-lg-12 {
    float: left;
  }
  .col-lg-12 {
    width: 100%;
  }
  .col-lg-11 {
    width: 91.66666667%;
  }
  .col-lg-10 {
    width: 83.33333333%;
  }
  .col-lg-9 {
    width: 75%;
  }
  .col-lg-8 {
    width: 66.66666667%;
  }
  .col-lg-7 {
    width: 58.33333333%;
  }
  .col-lg-6 {
    width: 50%;
  }
  .col-lg-5 {
    width: 41.66666667%;
  }
  .col-lg-4 {
    width: 33.33333333%;
  }
  .col-lg-3 {
    width: 25%;
  }
  .col-lg-2 {
    width: 16.66666667%;
  }
  .col-lg-1 {
    width: 8.33333333%;
  }
  .col-lg-pull-12 {
    right: 100%;
  }
  .col-lg-pull-11 {
    right: 91.66666667%;
  }
  .col-lg-pull-10 {
    right: 83.33333333%;
  }
  .col-lg-pull-9 {
    right: 75%;
  }
  .col-lg-pull-8 {
    right: 66.66666667%;
  }
  .col-lg-pull-7 {
    right: 58.33333333%;
  }
  .col-lg-pull-6 {
    right: 50%;
  }
  .col-lg-pull-5 {
    right: 41.66666667%;
  }
  .col-lg-pull-4 {
    right: 33.33333333%;
  }
  .col-lg-pull-3 {
    right: 25%;
  }
  .col-lg-pull-2 {
    right: 16.66666667%;
  }
  .col-lg-pull-1 {
    right: 8.33333333%;
  }
  .col-lg-pull-0 {
    right: auto;
  }
  .col-lg-push-12 {
    left: 100%;
  }
  .col-lg-push-11 {
    left: 91.66666667%;
  }
  .col-lg-push-10 {
    left: 83.33333333%;
  }
  .col-lg-push-9 {
    left: 75%;
  }
  .col-lg-push-8 {
    left: 66.66666667%;
  }
  .col-lg-push-7 {
    left: 58.33333333%;
  }
  .col-lg-push-6 {
    left: 50%;
  }
  .col-lg-push-5 {
    left: 41.66666667%;
  }
  .col-lg-push-4 {
    left: 33.33333333%;
  }
  .col-lg-push-3 {
    left: 25%;
  }
  .col-lg-push-2 {
    left: 16.66666667%;
  }
  .col-lg-push-1 {
    left: 8.33333333%;
  }
  .col-lg-push-0 {
    left: auto;
  }
  .col-lg-offset-12 {
    margin-left: 100%;
  }
  .col-lg-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-lg-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-lg-offset-9 {
    margin-left: 75%;
  }
  .col-lg-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-lg-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-lg-offset-6 {
    margin-left: 50%;
  }
  .col-lg-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-lg-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-lg-offset-3 {
    margin-left: 25%;
  }
  .col-lg-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-lg-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-lg-offset-0 {
    margin-left: 0%;
  }
}
table {
  background-color: transparent;
}
caption {
  padding-top: 8px;
  padding-bottom: 8px;
  color: #777777;
  text-align: left;
}
th {
  text-align: left;
}
.table {
  width: 100%;
  max-width: 100%;
  margin-bottom: 18px;
}
.table > thead > tr > th,
.table > tbody > tr > th,
.table > tfoot > tr > th,
.table > thead > tr > td,
.table > tbody > tr > td,
.table > tfoot > tr > td {
  padding: 8px;
  line-height: 1.42857143;
  vertical-align: top;
  border-top: 1px solid #ddd;
}
.table > thead > tr > th {
  vertical-align: bottom;
  border-bottom: 2px solid #ddd;
}
.table > caption + thead > tr:first-child > th,
.table > colgroup + thead > tr:first-child > th,
.table > thead:first-child > tr:first-child > th,
.table > caption + thead > tr:first-child > td,
.table > colgroup + thead > tr:first-child > td,
.table > thead:first-child > tr:first-child > td {
  border-top: 0;
}
.table > tbody + tbody {
  border-top: 2px solid #ddd;
}
.table .table {
  background-color: #fff;
}
.table-condensed > thead > tr > th,
.table-condensed > tbody > tr > th,
.table-condensed > tfoot > tr > th,
.table-condensed > thead > tr > td,
.table-condensed > tbody > tr > td,
.table-condensed > tfoot > tr > td {
  padding: 5px;
}
.table-bordered {
  border: 1px solid #ddd;
}
.table-bordered > thead > tr > th,
.table-bordered > tbody > tr > th,
.table-bordered > tfoot > tr > th,
.table-bordered > thead > tr > td,
.table-bordered > tbody > tr > td,
.table-bordered > tfoot > tr > td {
  border: 1px solid #ddd;
}
.table-bordered > thead > tr > th,
.table-bordered > thead > tr > td {
  border-bottom-width: 2px;
}
.table-striped > tbody > tr:nth-of-type(odd) {
  background-color: #f9f9f9;
}
.table-hover > tbody > tr:hover {
  background-color: #f5f5f5;
}
table col[class*="col-"] {
  position: static;
  float: none;
  display: table-column;
}
table td[class*="col-"],
table th[class*="col-"] {
  position: static;
  float: none;
  display: table-cell;
}
.table > thead > tr > td.active,
.table > tbody > tr > td.active,
.table > tfoot > tr > td.active,
.table > thead > tr > th.active,
.table > tbody > tr > th.active,
.table > tfoot > tr > th.active,
.table > thead > tr.active > td,
.table > tbody > tr.active > td,
.table > tfoot > tr.active > td,
.table > thead > tr.active > th,
.table > tbody > tr.active > th,
.table > tfoot > tr.active > th {
  background-color: #f5f5f5;
}
.table-hover > tbody > tr > td.active:hover,
.table-hover > tbody > tr > th.active:hover,
.table-hover > tbody > tr.active:hover > td,
.table-hover > tbody > tr:hover > .active,
.table-hover > tbody > tr.active:hover > th {
  background-color: #e8e8e8;
}
.table > thead > tr > td.success,
.table > tbody > tr > td.success,
.table > tfoot > tr > td.success,
.table > thead > tr > th.success,
.table > tbody > tr > th.success,
.table > tfoot > tr > th.success,
.table > thead > tr.success > td,
.table > tbody > tr.success > td,
.table > tfoot > tr.success > td,
.table > thead > tr.success > th,
.table > tbody > tr.success > th,
.table > tfoot > tr.success > th {
  background-color: #dff0d8;
}
.table-hover > tbody > tr > td.success:hover,
.table-hover > tbody > tr > th.success:hover,
.table-hover > tbody > tr.success:hover > td,
.table-hover > tbody > tr:hover > .success,
.table-hover > tbody > tr.success:hover > th {
  background-color: #d0e9c6;
}
.table > thead > tr > td.info,
.table > tbody > tr > td.info,
.table > tfoot > tr > td.info,
.table > thead > tr > th.info,
.table > tbody > tr > th.info,
.table > tfoot > tr > th.info,
.table > thead > tr.info > td,
.table > tbody > tr.info > td,
.table > tfoot > tr.info > td,
.table > thead > tr.info > th,
.table > tbody > tr.info > th,
.table > tfoot > tr.info > th {
  background-color: #d9edf7;
}
.table-hover > tbody > tr > td.info:hover,
.table-hover > tbody > tr > th.info:hover,
.table-hover > tbody > tr.info:hover > td,
.table-hover > tbody > tr:hover > .info,
.table-hover > tbody > tr.info:hover > th {
  background-color: #c4e3f3;
}
.table > thead > tr > td.warning,
.table > tbody > tr > td.warning,
.table > tfoot > tr > td.warning,
.table > thead > tr > th.warning,
.table > tbody > tr > th.warning,
.table > tfoot > tr > th.warning,
.table > thead > tr.warning > td,
.table > tbody > tr.warning > td,
.table > tfoot > tr.warning > td,
.table > thead > tr.warning > th,
.table > tbody > tr.warning > th,
.table > tfoot > tr.warning > th {
  background-color: #fcf8e3;
}
.table-hover > tbody > tr > td.warning:hover,
.table-hover > tbody > tr > th.warning:hover,
.table-hover > tbody > tr.warning:hover > td,
.table-hover > tbody > tr:hover > .warning,
.table-hover > tbody > tr.warning:hover > th {
  background-color: #faf2cc;
}
.table > thead > tr > td.danger,
.table > tbody > tr > td.danger,
.table > tfoot > tr > td.danger,
.table > thead > tr > th.danger,
.table > tbody > tr > th.danger,
.table > tfoot > tr > th.danger,
.table > thead > tr.danger > td,
.table > tbody > tr.danger > td,
.table > tfoot > tr.danger > td,
.table > thead > tr.danger > th,
.table > tbody > tr.danger > th,
.table > tfoot > tr.danger > th {
  background-color: #f2dede;
}
.table-hover > tbody > tr > td.danger:hover,
.table-hover > tbody > tr > th.danger:hover,
.table-hover > tbody > tr.danger:hover > td,
.table-hover > tbody > tr:hover > .danger,
.table-hover > tbody > tr.danger:hover > th {
  background-color: #ebcccc;
}
.table-responsive {
  overflow-x: auto;
  min-height: 0.01%;
}
@media screen and (max-width: 767px) {
  .table-responsive {
    width: 100%;
    margin-bottom: 13.5px;
    overflow-y: hidden;
    -ms-overflow-style: -ms-autohiding-scrollbar;
    border: 1px solid #ddd;
  }
  .table-responsive > .table {
    margin-bottom: 0;
  }
  .table-responsive > .table > thead > tr > th,
  .table-responsive > .table > tbody > tr > th,
  .table-responsive > .table > tfoot > tr > th,
  .table-responsive > .table > thead > tr > td,
  .table-responsive > .table > tbody > tr > td,
  .table-responsive > .table > tfoot > tr > td {
    white-space: nowrap;
  }
  .table-responsive > .table-bordered {
    border: 0;
  }
  .table-responsive > .table-bordered > thead > tr > th:first-child,
  .table-responsive > .table-bordered > tbody > tr > th:first-child,
  .table-responsive > .table-bordered > tfoot > tr > th:first-child,
  .table-responsive > .table-bordered > thead > tr > td:first-child,
  .table-responsive > .table-bordered > tbody > tr > td:first-child,
  .table-responsive > .table-bordered > tfoot > tr > td:first-child {
    border-left: 0;
  }
  .table-responsive > .table-bordered > thead > tr > th:last-child,
  .table-responsive > .table-bordered > tbody > tr > th:last-child,
  .table-responsive > .table-bordered > tfoot > tr > th:last-child,
  .table-responsive > .table-bordered > thead > tr > td:last-child,
  .table-responsive > .table-bordered > tbody > tr > td:last-child,
  .table-responsive > .table-bordered > tfoot > tr > td:last-child {
    border-right: 0;
  }
  .table-responsive > .table-bordered > tbody > tr:last-child > th,
  .table-responsive > .table-bordered > tfoot > tr:last-child > th,
  .table-responsive > .table-bordered > tbody > tr:last-child > td,
  .table-responsive > .table-bordered > tfoot > tr:last-child > td {
    border-bottom: 0;
  }
}
fieldset {
  padding: 0;
  margin: 0;
  border: 0;
  min-width: 0;
}
legend {
  display: block;
  width: 100%;
  padding: 0;
  margin-bottom: 18px;
  font-size: 19.5px;
  line-height: inherit;
  color: #333333;
  border: 0;
  border-bottom: 1px solid #e5e5e5;
}
label {
  display: inline-block;
  max-width: 100%;
  margin-bottom: 5px;
  font-weight: bold;
}
input[type="search"] {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
input[type="radio"],
input[type="checkbox"] {
  margin: 4px 0 0;
  margin-top: 1px \9;
  line-height: normal;
}
input[type="file"] {
  display: block;
}
input[type="range"] {
  display: block;
  width: 100%;
}
select[multiple],
select[size] {
  height: auto;
}
input[type="file"]:focus,
input[type="radio"]:focus,
input[type="checkbox"]:focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
output {
  display: block;
  padding-top: 7px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
}
.form-control {
  display: block;
  width: 100%;
  height: 32px;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
  background-color: #fff;
  background-image: none;
  border: 1px solid #ccc;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  -webkit-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  -o-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
}
.form-control:focus {
  border-color: #66afe9;
  outline: 0;
  -webkit-box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
  box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
}
.form-control::-moz-placeholder {
  color: #999;
  opacity: 1;
}
.form-control:-ms-input-placeholder {
  color: #999;
}
.form-control::-webkit-input-placeholder {
  color: #999;
}
.form-control::-ms-expand {
  border: 0;
  background-color: transparent;
}
.form-control[disabled],
.form-control[readonly],
fieldset[disabled] .form-control {
  background-color: #eeeeee;
  opacity: 1;
}
.form-control[disabled],
fieldset[disabled] .form-control {
  cursor: not-allowed;
}
textarea.form-control {
  height: auto;
}
input[type="search"] {
  -webkit-appearance: none;
}
@media screen and (-webkit-min-device-pixel-ratio: 0) {
  input[type="date"].form-control,
  input[type="time"].form-control,
  input[type="datetime-local"].form-control,
  input[type="month"].form-control {
    line-height: 32px;
  }
  input[type="date"].input-sm,
  input[type="time"].input-sm,
  input[type="datetime-local"].input-sm,
  input[type="month"].input-sm,
  .input-group-sm input[type="date"],
  .input-group-sm input[type="time"],
  .input-group-sm input[type="datetime-local"],
  .input-group-sm input[type="month"] {
    line-height: 30px;
  }
  input[type="date"].input-lg,
  input[type="time"].input-lg,
  input[type="datetime-local"].input-lg,
  input[type="month"].input-lg,
  .input-group-lg input[type="date"],
  .input-group-lg input[type="time"],
  .input-group-lg input[type="datetime-local"],
  .input-group-lg input[type="month"] {
    line-height: 45px;
  }
}
.form-group {
  margin-bottom: 15px;
}
.radio,
.checkbox {
  position: relative;
  display: block;
  margin-top: 10px;
  margin-bottom: 10px;
}
.radio label,
.checkbox label {
  min-height: 18px;
  padding-left: 20px;
  margin-bottom: 0;
  font-weight: normal;
  cursor: pointer;
}
.radio input[type="radio"],
.radio-inline input[type="radio"],
.checkbox input[type="checkbox"],
.checkbox-inline input[type="checkbox"] {
  position: absolute;
  margin-left: -20px;
  margin-top: 4px \9;
}
.radio + .radio,
.checkbox + .checkbox {
  margin-top: -5px;
}
.radio-inline,
.checkbox-inline {
  position: relative;
  display: inline-block;
  padding-left: 20px;
  margin-bottom: 0;
  vertical-align: middle;
  font-weight: normal;
  cursor: pointer;
}
.radio-inline + .radio-inline,
.checkbox-inline + .checkbox-inline {
  margin-top: 0;
  margin-left: 10px;
}
input[type="radio"][disabled],
input[type="checkbox"][disabled],
input[type="radio"].disabled,
input[type="checkbox"].disabled,
fieldset[disabled] input[type="radio"],
fieldset[disabled] input[type="checkbox"] {
  cursor: not-allowed;
}
.radio-inline.disabled,
.checkbox-inline.disabled,
fieldset[disabled] .radio-inline,
fieldset[disabled] .checkbox-inline {
  cursor: not-allowed;
}
.radio.disabled label,
.checkbox.disabled label,
fieldset[disabled] .radio label,
fieldset[disabled] .checkbox label {
  cursor: not-allowed;
}
.form-control-static {
  padding-top: 7px;
  padding-bottom: 7px;
  margin-bottom: 0;
  min-height: 31px;
}
.form-control-static.input-lg,
.form-control-static.input-sm {
  padding-left: 0;
  padding-right: 0;
}
.input-sm {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
select.input-sm {
  height: 30px;
  line-height: 30px;
}
textarea.input-sm,
select[multiple].input-sm {
  height: auto;
}
.form-group-sm .form-control {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.form-group-sm select.form-control {
  height: 30px;
  line-height: 30px;
}
.form-group-sm textarea.form-control,
.form-group-sm select[multiple].form-control {
  height: auto;
}
.form-group-sm .form-control-static {
  height: 30px;
  min-height: 30px;
  padding: 6px 10px;
  font-size: 12px;
  line-height: 1.5;
}
.input-lg {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
select.input-lg {
  height: 45px;
  line-height: 45px;
}
textarea.input-lg,
select[multiple].input-lg {
  height: auto;
}
.form-group-lg .form-control {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
.form-group-lg select.form-control {
  height: 45px;
  line-height: 45px;
}
.form-group-lg textarea.form-control,
.form-group-lg select[multiple].form-control {
  height: auto;
}
.form-group-lg .form-control-static {
  height: 45px;
  min-height: 35px;
  padding: 11px 16px;
  font-size: 17px;
  line-height: 1.3333333;
}
.has-feedback {
  position: relative;
}
.has-feedback .form-control {
  padding-right: 40px;
}
.form-control-feedback {
  position: absolute;
  top: 0;
  right: 0;
  z-index: 2;
  display: block;
  width: 32px;
  height: 32px;
  line-height: 32px;
  text-align: center;
  pointer-events: none;
}
.input-lg + .form-control-feedback,
.input-group-lg + .form-control-feedback,
.form-group-lg .form-control + .form-control-feedback {
  width: 45px;
  height: 45px;
  line-height: 45px;
}
.input-sm + .form-control-feedback,
.input-group-sm + .form-control-feedback,
.form-group-sm .form-control + .form-control-feedback {
  width: 30px;
  height: 30px;
  line-height: 30px;
}
.has-success .help-block,
.has-success .control-label,
.has-success .radio,
.has-success .checkbox,
.has-success .radio-inline,
.has-success .checkbox-inline,
.has-success.radio label,
.has-success.checkbox label,
.has-success.radio-inline label,
.has-success.checkbox-inline label {
  color: #3c763d;
}
.has-success .form-control {
  border-color: #3c763d;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-success .form-control:focus {
  border-color: #2b542c;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #67b168;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #67b168;
}
.has-success .input-group-addon {
  color: #3c763d;
  border-color: #3c763d;
  background-color: #dff0d8;
}
.has-success .form-control-feedback {
  color: #3c763d;
}
.has-warning .help-block,
.has-warning .control-label,
.has-warning .radio,
.has-warning .checkbox,
.has-warning .radio-inline,
.has-warning .checkbox-inline,
.has-warning.radio label,
.has-warning.checkbox label,
.has-warning.radio-inline label,
.has-warning.checkbox-inline label {
  color: #8a6d3b;
}
.has-warning .form-control {
  border-color: #8a6d3b;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-warning .form-control:focus {
  border-color: #66512c;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #c0a16b;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #c0a16b;
}
.has-warning .input-group-addon {
  color: #8a6d3b;
  border-color: #8a6d3b;
  background-color: #fcf8e3;
}
.has-warning .form-control-feedback {
  color: #8a6d3b;
}
.has-error .help-block,
.has-error .control-label,
.has-error .radio,
.has-error .checkbox,
.has-error .radio-inline,
.has-error .checkbox-inline,
.has-error.radio label,
.has-error.checkbox label,
.has-error.radio-inline label,
.has-error.checkbox-inline label {
  color: #a94442;
}
.has-error .form-control {
  border-color: #a94442;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-error .form-control:focus {
  border-color: #843534;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #ce8483;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #ce8483;
}
.has-error .input-group-addon {
  color: #a94442;
  border-color: #a94442;
  background-color: #f2dede;
}
.has-error .form-control-feedback {
  color: #a94442;
}
.has-feedback label ~ .form-control-feedback {
  top: 23px;
}
.has-feedback label.sr-only ~ .form-control-feedback {
  top: 0;
}
.help-block {
  display: block;
  margin-top: 5px;
  margin-bottom: 10px;
  color: #404040;
}
@media (min-width: 768px) {
  .form-inline .form-group {
    display: inline-block;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .form-control {
    display: inline-block;
    width: auto;
    vertical-align: middle;
  }
  .form-inline .form-control-static {
    display: inline-block;
  }
  .form-inline .input-group {
    display: inline-table;
    vertical-align: middle;
  }
  .form-inline .input-group .input-group-addon,
  .form-inline .input-group .input-group-btn,
  .form-inline .input-group .form-control {
    width: auto;
  }
  .form-inline .input-group > .form-control {
    width: 100%;
  }
  .form-inline .control-label {
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .radio,
  .form-inline .checkbox {
    display: inline-block;
    margin-top: 0;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .radio label,
  .form-inline .checkbox label {
    padding-left: 0;
  }
  .form-inline .radio input[type="radio"],
  .form-inline .checkbox input[type="checkbox"] {
    position: relative;
    margin-left: 0;
  }
  .form-inline .has-feedback .form-control-feedback {
    top: 0;
  }
}
.form-horizontal .radio,
.form-horizontal .checkbox,
.form-horizontal .radio-inline,
.form-horizontal .checkbox-inline {
  margin-top: 0;
  margin-bottom: 0;
  padding-top: 7px;
}
.form-horizontal .radio,
.form-horizontal .checkbox {
  min-height: 25px;
}
.form-horizontal .form-group {
  margin-left: 0px;
  margin-right: 0px;
}
@media (min-width: 768px) {
  .form-horizontal .control-label {
    text-align: right;
    margin-bottom: 0;
    padding-top: 7px;
  }
}
.form-horizontal .has-feedback .form-control-feedback {
  right: 0px;
}
@media (min-width: 768px) {
  .form-horizontal .form-group-lg .control-label {
    padding-top: 11px;
    font-size: 17px;
  }
}
@media (min-width: 768px) {
  .form-horizontal .form-group-sm .control-label {
    padding-top: 6px;
    font-size: 12px;
  }
}
.btn {
  display: inline-block;
  margin-bottom: 0;
  font-weight: normal;
  text-align: center;
  vertical-align: middle;
  touch-action: manipulation;
  cursor: pointer;
  background-image: none;
  border: 1px solid transparent;
  white-space: nowrap;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  border-radius: 2px;
  -webkit-user-select: none;
  -moz-user-select: none;
  -ms-user-select: none;
  user-select: none;
}
.btn:focus,
.btn:active:focus,
.btn.active:focus,
.btn.focus,
.btn:active.focus,
.btn.active.focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
.btn:hover,
.btn:focus,
.btn.focus {
  color: #333;
  text-decoration: none;
}
.btn:active,
.btn.active {
  outline: 0;
  background-image: none;
  -webkit-box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
  box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
}
.btn.disabled,
.btn[disabled],
fieldset[disabled] .btn {
  cursor: not-allowed;
  opacity: 0.65;
  filter: alpha(opacity=65);
  -webkit-box-shadow: none;
  box-shadow: none;
}
a.btn.disabled,
fieldset[disabled] a.btn {
  pointer-events: none;
}
.btn-default {
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
.btn-default:focus,
.btn-default.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
.btn-default:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.btn-default:active,
.btn-default.active,
.open > .dropdown-toggle.btn-default {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.btn-default:active:hover,
.btn-default.active:hover,
.open > .dropdown-toggle.btn-default:hover,
.btn-default:active:focus,
.btn-default.active:focus,
.open > .dropdown-toggle.btn-default:focus,
.btn-default:active.focus,
.btn-default.active.focus,
.open > .dropdown-toggle.btn-default.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
.btn-default:active,
.btn-default.active,
.open > .dropdown-toggle.btn-default {
  background-image: none;
}
.btn-default.disabled:hover,
.btn-default[disabled]:hover,
fieldset[disabled] .btn-default:hover,
.btn-default.disabled:focus,
.btn-default[disabled]:focus,
fieldset[disabled] .btn-default:focus,
.btn-default.disabled.focus,
.btn-default[disabled].focus,
fieldset[disabled] .btn-default.focus {
  background-color: #fff;
  border-color: #ccc;
}
.btn-default .badge {
  color: #fff;
  background-color: #333;
}
.btn-primary {
  color: #fff;
  background-color: #337ab7;
  border-color: #2e6da4;
}
.btn-primary:focus,
.btn-primary.focus {
  color: #fff;
  background-color: #286090;
  border-color: #122b40;
}
.btn-primary:hover {
  color: #fff;
  background-color: #286090;
  border-color: #204d74;
}
.btn-primary:active,
.btn-primary.active,
.open > .dropdown-toggle.btn-primary {
  color: #fff;
  background-color: #286090;
  border-color: #204d74;
}
.btn-primary:active:hover,
.btn-primary.active:hover,
.open > .dropdown-toggle.btn-primary:hover,
.btn-primary:active:focus,
.btn-primary.active:focus,
.open > .dropdown-toggle.btn-primary:focus,
.btn-primary:active.focus,
.btn-primary.active.focus,
.open > .dropdown-toggle.btn-primary.focus {
  color: #fff;
  background-color: #204d74;
  border-color: #122b40;
}
.btn-primary:active,
.btn-primary.active,
.open > .dropdown-toggle.btn-primary {
  background-image: none;
}
.btn-primary.disabled:hover,
.btn-primary[disabled]:hover,
fieldset[disabled] .btn-primary:hover,
.btn-primary.disabled:focus,
.btn-primary[disabled]:focus,
fieldset[disabled] .btn-primary:focus,
.btn-primary.disabled.focus,
.btn-primary[disabled].focus,
fieldset[disabled] .btn-primary.focus {
  background-color: #337ab7;
  border-color: #2e6da4;
}
.btn-primary .badge {
  color: #337ab7;
  background-color: #fff;
}
.btn-success {
  color: #fff;
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.btn-success:focus,
.btn-success.focus {
  color: #fff;
  background-color: #449d44;
  border-color: #255625;
}
.btn-success:hover {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.btn-success:active,
.btn-success.active,
.open > .dropdown-toggle.btn-success {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.btn-success:active:hover,
.btn-success.active:hover,
.open > .dropdown-toggle.btn-success:hover,
.btn-success:active:focus,
.btn-success.active:focus,
.open > .dropdown-toggle.btn-success:focus,
.btn-success:active.focus,
.btn-success.active.focus,
.open > .dropdown-toggle.btn-success.focus {
  color: #fff;
  background-color: #398439;
  border-color: #255625;
}
.btn-success:active,
.btn-success.active,
.open > .dropdown-toggle.btn-success {
  background-image: none;
}
.btn-success.disabled:hover,
.btn-success[disabled]:hover,
fieldset[disabled] .btn-success:hover,
.btn-success.disabled:focus,
.btn-success[disabled]:focus,
fieldset[disabled] .btn-success:focus,
.btn-success.disabled.focus,
.btn-success[disabled].focus,
fieldset[disabled] .btn-success.focus {
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.btn-success .badge {
  color: #5cb85c;
  background-color: #fff;
}
.btn-info {
  color: #fff;
  background-color: #5bc0de;
  border-color: #46b8da;
}
.btn-info:focus,
.btn-info.focus {
  color: #fff;
  background-color: #31b0d5;
  border-color: #1b6d85;
}
.btn-info:hover {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.btn-info:active,
.btn-info.active,
.open > .dropdown-toggle.btn-info {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.btn-info:active:hover,
.btn-info.active:hover,
.open > .dropdown-toggle.btn-info:hover,
.btn-info:active:focus,
.btn-info.active:focus,
.open > .dropdown-toggle.btn-info:focus,
.btn-info:active.focus,
.btn-info.active.focus,
.open > .dropdown-toggle.btn-info.focus {
  color: #fff;
  background-color: #269abc;
  border-color: #1b6d85;
}
.btn-info:active,
.btn-info.active,
.open > .dropdown-toggle.btn-info {
  background-image: none;
}
.btn-info.disabled:hover,
.btn-info[disabled]:hover,
fieldset[disabled] .btn-info:hover,
.btn-info.disabled:focus,
.btn-info[disabled]:focus,
fieldset[disabled] .btn-info:focus,
.btn-info.disabled.focus,
.btn-info[disabled].focus,
fieldset[disabled] .btn-info.focus {
  background-color: #5bc0de;
  border-color: #46b8da;
}
.btn-info .badge {
  color: #5bc0de;
  background-color: #fff;
}
.btn-warning {
  color: #fff;
  background-color: #f0ad4e;
  border-color: #eea236;
}
.btn-warning:focus,
.btn-warning.focus {
  color: #fff;
  background-color: #ec971f;
  border-color: #985f0d;
}
.btn-warning:hover {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.btn-warning:active,
.btn-warning.active,
.open > .dropdown-toggle.btn-warning {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.btn-warning:active:hover,
.btn-warning.active:hover,
.open > .dropdown-toggle.btn-warning:hover,
.btn-warning:active:focus,
.btn-warning.active:focus,
.open > .dropdown-toggle.btn-warning:focus,
.btn-warning:active.focus,
.btn-warning.active.focus,
.open > .dropdown-toggle.btn-warning.focus {
  color: #fff;
  background-color: #d58512;
  border-color: #985f0d;
}
.btn-warning:active,
.btn-warning.active,
.open > .dropdown-toggle.btn-warning {
  background-image: none;
}
.btn-warning.disabled:hover,
.btn-warning[disabled]:hover,
fieldset[disabled] .btn-warning:hover,
.btn-warning.disabled:focus,
.btn-warning[disabled]:focus,
fieldset[disabled] .btn-warning:focus,
.btn-warning.disabled.focus,
.btn-warning[disabled].focus,
fieldset[disabled] .btn-warning.focus {
  background-color: #f0ad4e;
  border-color: #eea236;
}
.btn-warning .badge {
  color: #f0ad4e;
  background-color: #fff;
}
.btn-danger {
  color: #fff;
  background-color: #d9534f;
  border-color: #d43f3a;
}
.btn-danger:focus,
.btn-danger.focus {
  color: #fff;
  background-color: #c9302c;
  border-color: #761c19;
}
.btn-danger:hover {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.btn-danger:active,
.btn-danger.active,
.open > .dropdown-toggle.btn-danger {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.btn-danger:active:hover,
.btn-danger.active:hover,
.open > .dropdown-toggle.btn-danger:hover,
.btn-danger:active:focus,
.btn-danger.active:focus,
.open > .dropdown-toggle.btn-danger:focus,
.btn-danger:active.focus,
.btn-danger.active.focus,
.open > .dropdown-toggle.btn-danger.focus {
  color: #fff;
  background-color: #ac2925;
  border-color: #761c19;
}
.btn-danger:active,
.btn-danger.active,
.open > .dropdown-toggle.btn-danger {
  background-image: none;
}
.btn-danger.disabled:hover,
.btn-danger[disabled]:hover,
fieldset[disabled] .btn-danger:hover,
.btn-danger.disabled:focus,
.btn-danger[disabled]:focus,
fieldset[disabled] .btn-danger:focus,
.btn-danger.disabled.focus,
.btn-danger[disabled].focus,
fieldset[disabled] .btn-danger.focus {
  background-color: #d9534f;
  border-color: #d43f3a;
}
.btn-danger .badge {
  color: #d9534f;
  background-color: #fff;
}
.btn-link {
  color: #337ab7;
  font-weight: normal;
  border-radius: 0;
}
.btn-link,
.btn-link:active,
.btn-link.active,
.btn-link[disabled],
fieldset[disabled] .btn-link {
  background-color: transparent;
  -webkit-box-shadow: none;
  box-shadow: none;
}
.btn-link,
.btn-link:hover,
.btn-link:focus,
.btn-link:active {
  border-color: transparent;
}
.btn-link:hover,
.btn-link:focus {
  color: #23527c;
  text-decoration: underline;
  background-color: transparent;
}
.btn-link[disabled]:hover,
fieldset[disabled] .btn-link:hover,
.btn-link[disabled]:focus,
fieldset[disabled] .btn-link:focus {
  color: #777777;
  text-decoration: none;
}
.btn-lg,
.btn-group-lg > .btn {
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
.btn-sm,
.btn-group-sm > .btn {
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.btn-xs,
.btn-group-xs > .btn {
  padding: 1px 5px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.btn-block {
  display: block;
  width: 100%;
}
.btn-block + .btn-block {
  margin-top: 5px;
}
input[type="submit"].btn-block,
input[type="reset"].btn-block,
input[type="button"].btn-block {
  width: 100%;
}
.fade {
  opacity: 0;
  -webkit-transition: opacity 0.15s linear;
  -o-transition: opacity 0.15s linear;
  transition: opacity 0.15s linear;
}
.fade.in {
  opacity: 1;
}
.collapse {
  display: none;
}
.collapse.in {
  display: block;
}
tr.collapse.in {
  display: table-row;
}
tbody.collapse.in {
  display: table-row-group;
}
.collapsing {
  position: relative;
  height: 0;
  overflow: hidden;
  -webkit-transition-property: height, visibility;
  transition-property: height, visibility;
  -webkit-transition-duration: 0.35s;
  transition-duration: 0.35s;
  -webkit-transition-timing-function: ease;
  transition-timing-function: ease;
}
.caret {
  display: inline-block;
  width: 0;
  height: 0;
  margin-left: 2px;
  vertical-align: middle;
  border-top: 4px dashed;
  border-top: 4px solid \9;
  border-right: 4px solid transparent;
  border-left: 4px solid transparent;
}
.dropup,
.dropdown {
  position: relative;
}
.dropdown-toggle:focus {
  outline: 0;
}
.dropdown-menu {
  position: absolute;
  top: 100%;
  left: 0;
  z-index: 1000;
  display: none;
  float: left;
  min-width: 160px;
  padding: 5px 0;
  margin: 2px 0 0;
  list-style: none;
  font-size: 13px;
  text-align: left;
  background-color: #fff;
  border: 1px solid #ccc;
  border: 1px solid rgba(0, 0, 0, 0.15);
  border-radius: 2px;
  -webkit-box-shadow: 0 6px 12px rgba(0, 0, 0, 0.175);
  box-shadow: 0 6px 12px rgba(0, 0, 0, 0.175);
  background-clip: padding-box;
}
.dropdown-menu.pull-right {
  right: 0;
  left: auto;
}
.dropdown-menu .divider {
  height: 1px;
  margin: 8px 0;
  overflow: hidden;
  background-color: #e5e5e5;
}
.dropdown-menu > li > a {
  display: block;
  padding: 3px 20px;
  clear: both;
  font-weight: normal;
  line-height: 1.42857143;
  color: #333333;
  white-space: nowrap;
}
.dropdown-menu > li > a:hover,
.dropdown-menu > li > a:focus {
  text-decoration: none;
  color: #262626;
  background-color: #f5f5f5;
}
.dropdown-menu > .active > a,
.dropdown-menu > .active > a:hover,
.dropdown-menu > .active > a:focus {
  color: #fff;
  text-decoration: none;
  outline: 0;
  background-color: #337ab7;
}
.dropdown-menu > .disabled > a,
.dropdown-menu > .disabled > a:hover,
.dropdown-menu > .disabled > a:focus {
  color: #777777;
}
.dropdown-menu > .disabled > a:hover,
.dropdown-menu > .disabled > a:focus {
  text-decoration: none;
  background-color: transparent;
  background-image: none;
  filter: progid:DXImageTransform.Microsoft.gradient(enabled = false);
  cursor: not-allowed;
}
.open > .dropdown-menu {
  display: block;
}
.open > a {
  outline: 0;
}
.dropdown-menu-right {
  left: auto;
  right: 0;
}
.dropdown-menu-left {
  left: 0;
  right: auto;
}
.dropdown-header {
  display: block;
  padding: 3px 20px;
  font-size: 12px;
  line-height: 1.42857143;
  color: #777777;
  white-space: nowrap;
}
.dropdown-backdrop {
  position: fixed;
  left: 0;
  right: 0;
  bottom: 0;
  top: 0;
  z-index: 990;
}
.pull-right > .dropdown-menu {
  right: 0;
  left: auto;
}
.dropup .caret,
.navbar-fixed-bottom .dropdown .caret {
  border-top: 0;
  border-bottom: 4px dashed;
  border-bottom: 4px solid \9;
  content: "";
}
.dropup .dropdown-menu,
.navbar-fixed-bottom .dropdown .dropdown-menu {
  top: auto;
  bottom: 100%;
  margin-bottom: 2px;
}
@media (min-width: 541px) {
  .navbar-right .dropdown-menu {
    left: auto;
    right: 0;
  }
  .navbar-right .dropdown-menu-left {
    left: 0;
    right: auto;
  }
}
.btn-group,
.btn-group-vertical {
  position: relative;
  display: inline-block;
  vertical-align: middle;
}
.btn-group > .btn,
.btn-group-vertical > .btn {
  position: relative;
  float: left;
}
.btn-group > .btn:hover,
.btn-group-vertical > .btn:hover,
.btn-group > .btn:focus,
.btn-group-vertical > .btn:focus,
.btn-group > .btn:active,
.btn-group-vertical > .btn:active,
.btn-group > .btn.active,
.btn-group-vertical > .btn.active {
  z-index: 2;
}
.btn-group .btn + .btn,
.btn-group .btn + .btn-group,
.btn-group .btn-group + .btn,
.btn-group .btn-group + .btn-group {
  margin-left: -1px;
}
.btn-toolbar {
  margin-left: -5px;
}
.btn-toolbar .btn,
.btn-toolbar .btn-group,
.btn-toolbar .input-group {
  float: left;
}
.btn-toolbar > .btn,
.btn-toolbar > .btn-group,
.btn-toolbar > .input-group {
  margin-left: 5px;
}
.btn-group > .btn:not(:first-child):not(:last-child):not(.dropdown-toggle) {
  border-radius: 0;
}
.btn-group > .btn:first-child {
  margin-left: 0;
}
.btn-group > .btn:first-child:not(:last-child):not(.dropdown-toggle) {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.btn-group > .btn:last-child:not(:first-child),
.btn-group > .dropdown-toggle:not(:first-child) {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.btn-group > .btn-group {
  float: left;
}
.btn-group > .btn-group:not(:first-child):not(:last-child) > .btn {
  border-radius: 0;
}
.btn-group > .btn-group:first-child:not(:last-child) > .btn:last-child,
.btn-group > .btn-group:first-child:not(:last-child) > .dropdown-toggle {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.btn-group > .btn-group:last-child:not(:first-child) > .btn:first-child {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.btn-group .dropdown-toggle:active,
.btn-group.open .dropdown-toggle {
  outline: 0;
}
.btn-group > .btn + .dropdown-toggle {
  padding-left: 8px;
  padding-right: 8px;
}
.btn-group > .btn-lg + .dropdown-toggle {
  padding-left: 12px;
  padding-right: 12px;
}
.btn-group.open .dropdown-toggle {
  -webkit-box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
  box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
}
.btn-group.open .dropdown-toggle.btn-link {
  -webkit-box-shadow: none;
  box-shadow: none;
}
.btn .caret {
  margin-left: 0;
}
.btn-lg .caret {
  border-width: 5px 5px 0;
  border-bottom-width: 0;
}
.dropup .btn-lg .caret {
  border-width: 0 5px 5px;
}
.btn-group-vertical > .btn,
.btn-group-vertical > .btn-group,
.btn-group-vertical > .btn-group > .btn {
  display: block;
  float: none;
  width: 100%;
  max-width: 100%;
}
.btn-group-vertical > .btn-group > .btn {
  float: none;
}
.btn-group-vertical > .btn + .btn,
.btn-group-vertical > .btn + .btn-group,
.btn-group-vertical > .btn-group + .btn,
.btn-group-vertical > .btn-group + .btn-group {
  margin-top: -1px;
  margin-left: 0;
}
.btn-group-vertical > .btn:not(:first-child):not(:last-child) {
  border-radius: 0;
}
.btn-group-vertical > .btn:first-child:not(:last-child) {
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.btn-group-vertical > .btn:last-child:not(:first-child) {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
  border-bottom-right-radius: 2px;
  border-bottom-left-radius: 2px;
}
.btn-group-vertical > .btn-group:not(:first-child):not(:last-child) > .btn {
  border-radius: 0;
}
.btn-group-vertical > .btn-group:first-child:not(:last-child) > .btn:last-child,
.btn-group-vertical > .btn-group:first-child:not(:last-child) > .dropdown-toggle {
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.btn-group-vertical > .btn-group:last-child:not(:first-child) > .btn:first-child {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.btn-group-justified {
  display: table;
  width: 100%;
  table-layout: fixed;
  border-collapse: separate;
}
.btn-group-justified > .btn,
.btn-group-justified > .btn-group {
  float: none;
  display: table-cell;
  width: 1%;
}
.btn-group-justified > .btn-group .btn {
  width: 100%;
}
.btn-group-justified > .btn-group .dropdown-menu {
  left: auto;
}
[data-toggle="buttons"] > .btn input[type="radio"],
[data-toggle="buttons"] > .btn-group > .btn input[type="radio"],
[data-toggle="buttons"] > .btn input[type="checkbox"],
[data-toggle="buttons"] > .btn-group > .btn input[type="checkbox"] {
  position: absolute;
  clip: rect(0, 0, 0, 0);
  pointer-events: none;
}
.input-group {
  position: relative;
  display: table;
  border-collapse: separate;
}
.input-group[class*="col-"] {
  float: none;
  padding-left: 0;
  padding-right: 0;
}
.input-group .form-control {
  position: relative;
  z-index: 2;
  float: left;
  width: 100%;
  margin-bottom: 0;
}
.input-group .form-control:focus {
  z-index: 3;
}
.input-group-lg > .form-control,
.input-group-lg > .input-group-addon,
.input-group-lg > .input-group-btn > .btn {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
select.input-group-lg > .form-control,
select.input-group-lg > .input-group-addon,
select.input-group-lg > .input-group-btn > .btn {
  height: 45px;
  line-height: 45px;
}
textarea.input-group-lg > .form-control,
textarea.input-group-lg > .input-group-addon,
textarea.input-group-lg > .input-group-btn > .btn,
select[multiple].input-group-lg > .form-control,
select[multiple].input-group-lg > .input-group-addon,
select[multiple].input-group-lg > .input-group-btn > .btn {
  height: auto;
}
.input-group-sm > .form-control,
.input-group-sm > .input-group-addon,
.input-group-sm > .input-group-btn > .btn {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
select.input-group-sm > .form-control,
select.input-group-sm > .input-group-addon,
select.input-group-sm > .input-group-btn > .btn {
  height: 30px;
  line-height: 30px;
}
textarea.input-group-sm > .form-control,
textarea.input-group-sm > .input-group-addon,
textarea.input-group-sm > .input-group-btn > .btn,
select[multiple].input-group-sm > .form-control,
select[multiple].input-group-sm > .input-group-addon,
select[multiple].input-group-sm > .input-group-btn > .btn {
  height: auto;
}
.input-group-addon,
.input-group-btn,
.input-group .form-control {
  display: table-cell;
}
.input-group-addon:not(:first-child):not(:last-child),
.input-group-btn:not(:first-child):not(:last-child),
.input-group .form-control:not(:first-child):not(:last-child) {
  border-radius: 0;
}
.input-group-addon,
.input-group-btn {
  width: 1%;
  white-space: nowrap;
  vertical-align: middle;
}
.input-group-addon {
  padding: 6px 12px;
  font-size: 13px;
  font-weight: normal;
  line-height: 1;
  color: #555555;
  text-align: center;
  background-color: #eeeeee;
  border: 1px solid #ccc;
  border-radius: 2px;
}
.input-group-addon.input-sm {
  padding: 5px 10px;
  font-size: 12px;
  border-radius: 1px;
}
.input-group-addon.input-lg {
  padding: 10px 16px;
  font-size: 17px;
  border-radius: 3px;
}
.input-group-addon input[type="radio"],
.input-group-addon input[type="checkbox"] {
  margin-top: 0;
}
.input-group .form-control:first-child,
.input-group-addon:first-child,
.input-group-btn:first-child > .btn,
.input-group-btn:first-child > .btn-group > .btn,
.input-group-btn:first-child > .dropdown-toggle,
.input-group-btn:last-child > .btn:not(:last-child):not(.dropdown-toggle),
.input-group-btn:last-child > .btn-group:not(:last-child) > .btn {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.input-group-addon:first-child {
  border-right: 0;
}
.input-group .form-control:last-child,
.input-group-addon:last-child,
.input-group-btn:last-child > .btn,
.input-group-btn:last-child > .btn-group > .btn,
.input-group-btn:last-child > .dropdown-toggle,
.input-group-btn:first-child > .btn:not(:first-child),
.input-group-btn:first-child > .btn-group:not(:first-child) > .btn {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.input-group-addon:last-child {
  border-left: 0;
}
.input-group-btn {
  position: relative;
  font-size: 0;
  white-space: nowrap;
}
.input-group-btn > .btn {
  position: relative;
}
.input-group-btn > .btn + .btn {
  margin-left: -1px;
}
.input-group-btn > .btn:hover,
.input-group-btn > .btn:focus,
.input-group-btn > .btn:active {
  z-index: 2;
}
.input-group-btn:first-child > .btn,
.input-group-btn:first-child > .btn-group {
  margin-right: -1px;
}
.input-group-btn:last-child > .btn,
.input-group-btn:last-child > .btn-group {
  z-index: 2;
  margin-left: -1px;
}
.nav {
  margin-bottom: 0;
  padding-left: 0;
  list-style: none;
}
.nav > li {
  position: relative;
  display: block;
}
.nav > li > a {
  position: relative;
  display: block;
  padding: 10px 15px;
}
.nav > li > a:hover,
.nav > li > a:focus {
  text-decoration: none;
  background-color: #eeeeee;
}
.nav > li.disabled > a {
  color: #777777;
}
.nav > li.disabled > a:hover,
.nav > li.disabled > a:focus {
  color: #777777;
  text-decoration: none;
  background-color: transparent;
  cursor: not-allowed;
}
.nav .open > a,
.nav .open > a:hover,
.nav .open > a:focus {
  background-color: #eeeeee;
  border-color: #337ab7;
}
.nav .nav-divider {
  height: 1px;
  margin: 8px 0;
  overflow: hidden;
  background-color: #e5e5e5;
}
.nav > li > a > img {
  max-width: none;
}
.nav-tabs {
  border-bottom: 1px solid #ddd;
}
.nav-tabs > li {
  float: left;
  margin-bottom: -1px;
}
.nav-tabs > li > a {
  margin-right: 2px;
  line-height: 1.42857143;
  border: 1px solid transparent;
  border-radius: 2px 2px 0 0;
}
.nav-tabs > li > a:hover {
  border-color: #eeeeee #eeeeee #ddd;
}
.nav-tabs > li.active > a,
.nav-tabs > li.active > a:hover,
.nav-tabs > li.active > a:focus {
  color: #555555;
  background-color: #fff;
  border: 1px solid #ddd;
  border-bottom-color: transparent;
  cursor: default;
}
.nav-tabs.nav-justified {
  width: 100%;
  border-bottom: 0;
}
.nav-tabs.nav-justified > li {
  float: none;
}
.nav-tabs.nav-justified > li > a {
  text-align: center;
  margin-bottom: 5px;
}
.nav-tabs.nav-justified > .dropdown .dropdown-menu {
  top: auto;
  left: auto;
}
@media (min-width: 768px) {
  .nav-tabs.nav-justified > li {
    display: table-cell;
    width: 1%;
  }
  .nav-tabs.nav-justified > li > a {
    margin-bottom: 0;
  }
}
.nav-tabs.nav-justified > li > a {
  margin-right: 0;
  border-radius: 2px;
}
.nav-tabs.nav-justified > .active > a,
.nav-tabs.nav-justified > .active > a:hover,
.nav-tabs.nav-justified > .active > a:focus {
  border: 1px solid #ddd;
}
@media (min-width: 768px) {
  .nav-tabs.nav-justified > li > a {
    border-bottom: 1px solid #ddd;
    border-radius: 2px 2px 0 0;
  }
  .nav-tabs.nav-justified > .active > a,
  .nav-tabs.nav-justified > .active > a:hover,
  .nav-tabs.nav-justified > .active > a:focus {
    border-bottom-color: #fff;
  }
}
.nav-pills > li {
  float: left;
}
.nav-pills > li > a {
  border-radius: 2px;
}
.nav-pills > li + li {
  margin-left: 2px;
}
.nav-pills > li.active > a,
.nav-pills > li.active > a:hover,
.nav-pills > li.active > a:focus {
  color: #fff;
  background-color: #337ab7;
}
.nav-stacked > li {
  float: none;
}
.nav-stacked > li + li {
  margin-top: 2px;
  margin-left: 0;
}
.nav-justified {
  width: 100%;
}
.nav-justified > li {
  float: none;
}
.nav-justified > li > a {
  text-align: center;
  margin-bottom: 5px;
}
.nav-justified > .dropdown .dropdown-menu {
  top: auto;
  left: auto;
}
@media (min-width: 768px) {
  .nav-justified > li {
    display: table-cell;
    width: 1%;
  }
  .nav-justified > li > a {
    margin-bottom: 0;
  }
}
.nav-tabs-justified {
  border-bottom: 0;
}
.nav-tabs-justified > li > a {
  margin-right: 0;
  border-radius: 2px;
}
.nav-tabs-justified > .active > a,
.nav-tabs-justified > .active > a:hover,
.nav-tabs-justified > .active > a:focus {
  border: 1px solid #ddd;
}
@media (min-width: 768px) {
  .nav-tabs-justified > li > a {
    border-bottom: 1px solid #ddd;
    border-radius: 2px 2px 0 0;
  }
  .nav-tabs-justified > .active > a,
  .nav-tabs-justified > .active > a:hover,
  .nav-tabs-justified > .active > a:focus {
    border-bottom-color: #fff;
  }
}
.tab-content > .tab-pane {
  display: none;
}
.tab-content > .active {
  display: block;
}
.nav-tabs .dropdown-menu {
  margin-top: -1px;
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.navbar {
  position: relative;
  min-height: 30px;
  margin-bottom: 18px;
  border: 1px solid transparent;
}
@media (min-width: 541px) {
  .navbar {
    border-radius: 2px;
  }
}
@media (min-width: 541px) {
  .navbar-header {
    float: left;
  }
}
.navbar-collapse {
  overflow-x: visible;
  padding-right: 0px;
  padding-left: 0px;
  border-top: 1px solid transparent;
  box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1);
  -webkit-overflow-scrolling: touch;
}
.navbar-collapse.in {
  overflow-y: auto;
}
@media (min-width: 541px) {
  .navbar-collapse {
    width: auto;
    border-top: 0;
    box-shadow: none;
  }
  .navbar-collapse.collapse {
    display: block !important;
    height: auto !important;
    padding-bottom: 0;
    overflow: visible !important;
  }
  .navbar-collapse.in {
    overflow-y: visible;
  }
  .navbar-fixed-top .navbar-collapse,
  .navbar-static-top .navbar-collapse,
  .navbar-fixed-bottom .navbar-collapse {
    padding-left: 0;
    padding-right: 0;
  }
}
.navbar-fixed-top .navbar-collapse,
.navbar-fixed-bottom .navbar-collapse {
  max-height: 340px;
}
@media (max-device-width: 540px) and (orientation: landscape) {
  .navbar-fixed-top .navbar-collapse,
  .navbar-fixed-bottom .navbar-collapse {
    max-height: 200px;
  }
}
.container > .navbar-header,
.container-fluid > .navbar-header,
.container > .navbar-collapse,
.container-fluid > .navbar-collapse {
  margin-right: 0px;
  margin-left: 0px;
}
@media (min-width: 541px) {
  .container > .navbar-header,
  .container-fluid > .navbar-header,
  .container > .navbar-collapse,
  .container-fluid > .navbar-collapse {
    margin-right: 0;
    margin-left: 0;
  }
}
.navbar-static-top {
  z-index: 1000;
  border-width: 0 0 1px;
}
@media (min-width: 541px) {
  .navbar-static-top {
    border-radius: 0;
  }
}
.navbar-fixed-top,
.navbar-fixed-bottom {
  position: fixed;
  right: 0;
  left: 0;
  z-index: 1030;
}
@media (min-width: 541px) {
  .navbar-fixed-top,
  .navbar-fixed-bottom {
    border-radius: 0;
  }
}
.navbar-fixed-top {
  top: 0;
  border-width: 0 0 1px;
}
.navbar-fixed-bottom {
  bottom: 0;
  margin-bottom: 0;
  border-width: 1px 0 0;
}
.navbar-brand {
  float: left;
  padding: 6px 0px;
  font-size: 17px;
  line-height: 18px;
  height: 30px;
}
.navbar-brand:hover,
.navbar-brand:focus {
  text-decoration: none;
}
.navbar-brand > img {
  display: block;
}
@media (min-width: 541px) {
  .navbar > .container .navbar-brand,
  .navbar > .container-fluid .navbar-brand {
    margin-left: 0px;
  }
}
.navbar-toggle {
  position: relative;
  float: right;
  margin-right: 0px;
  padding: 9px 10px;
  margin-top: -2px;
  margin-bottom: -2px;
  background-color: transparent;
  background-image: none;
  border: 1px solid transparent;
  border-radius: 2px;
}
.navbar-toggle:focus {
  outline: 0;
}
.navbar-toggle .icon-bar {
  display: block;
  width: 22px;
  height: 2px;
  border-radius: 1px;
}
.navbar-toggle .icon-bar + .icon-bar {
  margin-top: 4px;
}
@media (min-width: 541px) {
  .navbar-toggle {
    display: none;
  }
}
.navbar-nav {
  margin: 3px 0px;
}
.navbar-nav > li > a {
  padding-top: 10px;
  padding-bottom: 10px;
  line-height: 18px;
}
@media (max-width: 540px) {
  .navbar-nav .open .dropdown-menu {
    position: static;
    float: none;
    width: auto;
    margin-top: 0;
    background-color: transparent;
    border: 0;
    box-shadow: none;
  }
  .navbar-nav .open .dropdown-menu > li > a,
  .navbar-nav .open .dropdown-menu .dropdown-header {
    padding: 5px 15px 5px 25px;
  }
  .navbar-nav .open .dropdown-menu > li > a {
    line-height: 18px;
  }
  .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-nav .open .dropdown-menu > li > a:focus {
    background-image: none;
  }
}
@media (min-width: 541px) {
  .navbar-nav {
    float: left;
    margin: 0;
  }
  .navbar-nav > li {
    float: left;
  }
  .navbar-nav > li > a {
    padding-top: 6px;
    padding-bottom: 6px;
  }
}
.navbar-form {
  margin-left: 0px;
  margin-right: 0px;
  padding: 10px 0px;
  border-top: 1px solid transparent;
  border-bottom: 1px solid transparent;
  -webkit-box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1), 0 1px 0 rgba(255, 255, 255, 0.1);
  box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1), 0 1px 0 rgba(255, 255, 255, 0.1);
  margin-top: -1px;
  margin-bottom: -1px;
}
@media (min-width: 768px) {
  .navbar-form .form-group {
    display: inline-block;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .form-control {
    display: inline-block;
    width: auto;
    vertical-align: middle;
  }
  .navbar-form .form-control-static {
    display: inline-block;
  }
  .navbar-form .input-group {
    display: inline-table;
    vertical-align: middle;
  }
  .navbar-form .input-group .input-group-addon,
  .navbar-form .input-group .input-group-btn,
  .navbar-form .input-group .form-control {
    width: auto;
  }
  .navbar-form .input-group > .form-control {
    width: 100%;
  }
  .navbar-form .control-label {
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .radio,
  .navbar-form .checkbox {
    display: inline-block;
    margin-top: 0;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .radio label,
  .navbar-form .checkbox label {
    padding-left: 0;
  }
  .navbar-form .radio input[type="radio"],
  .navbar-form .checkbox input[type="checkbox"] {
    position: relative;
    margin-left: 0;
  }
  .navbar-form .has-feedback .form-control-feedback {
    top: 0;
  }
}
@media (max-width: 540px) {
  .navbar-form .form-group {
    margin-bottom: 5px;
  }
  .navbar-form .form-group:last-child {
    margin-bottom: 0;
  }
}
@media (min-width: 541px) {
  .navbar-form {
    width: auto;
    border: 0;
    margin-left: 0;
    margin-right: 0;
    padding-top: 0;
    padding-bottom: 0;
    -webkit-box-shadow: none;
    box-shadow: none;
  }
}
.navbar-nav > li > .dropdown-menu {
  margin-top: 0;
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.navbar-fixed-bottom .navbar-nav > li > .dropdown-menu {
  margin-bottom: 0;
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.navbar-btn {
  margin-top: -1px;
  margin-bottom: -1px;
}
.navbar-btn.btn-sm {
  margin-top: 0px;
  margin-bottom: 0px;
}
.navbar-btn.btn-xs {
  margin-top: 4px;
  margin-bottom: 4px;
}
.navbar-text {
  margin-top: 6px;
  margin-bottom: 6px;
}
@media (min-width: 541px) {
  .navbar-text {
    float: left;
    margin-left: 0px;
    margin-right: 0px;
  }
}
@media (min-width: 541px) {
  .navbar-left {
    float: left !important;
    float: left;
  }
  .navbar-right {
    float: right !important;
    float: right;
    margin-right: 0px;
  }
  .navbar-right ~ .navbar-right {
    margin-right: 0;
  }
}
.navbar-default {
  background-color: #f8f8f8;
  border-color: #e7e7e7;
}
.navbar-default .navbar-brand {
  color: #777;
}
.navbar-default .navbar-brand:hover,
.navbar-default .navbar-brand:focus {
  color: #5e5e5e;
  background-color: transparent;
}
.navbar-default .navbar-text {
  color: #777;
}
.navbar-default .navbar-nav > li > a {
  color: #777;
}
.navbar-default .navbar-nav > li > a:hover,
.navbar-default .navbar-nav > li > a:focus {
  color: #333;
  background-color: transparent;
}
.navbar-default .navbar-nav > .active > a,
.navbar-default .navbar-nav > .active > a:hover,
.navbar-default .navbar-nav > .active > a:focus {
  color: #555;
  background-color: #e7e7e7;
}
.navbar-default .navbar-nav > .disabled > a,
.navbar-default .navbar-nav > .disabled > a:hover,
.navbar-default .navbar-nav > .disabled > a:focus {
  color: #ccc;
  background-color: transparent;
}
.navbar-default .navbar-toggle {
  border-color: #ddd;
}
.navbar-default .navbar-toggle:hover,
.navbar-default .navbar-toggle:focus {
  background-color: #ddd;
}
.navbar-default .navbar-toggle .icon-bar {
  background-color: #888;
}
.navbar-default .navbar-collapse,
.navbar-default .navbar-form {
  border-color: #e7e7e7;
}
.navbar-default .navbar-nav > .open > a,
.navbar-default .navbar-nav > .open > a:hover,
.navbar-default .navbar-nav > .open > a:focus {
  background-color: #e7e7e7;
  color: #555;
}
@media (max-width: 540px) {
  .navbar-default .navbar-nav .open .dropdown-menu > li > a {
    color: #777;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > li > a:focus {
    color: #333;
    background-color: transparent;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a,
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a:focus {
    color: #555;
    background-color: #e7e7e7;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a,
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a:focus {
    color: #ccc;
    background-color: transparent;
  }
}
.navbar-default .navbar-link {
  color: #777;
}
.navbar-default .navbar-link:hover {
  color: #333;
}
.navbar-default .btn-link {
  color: #777;
}
.navbar-default .btn-link:hover,
.navbar-default .btn-link:focus {
  color: #333;
}
.navbar-default .btn-link[disabled]:hover,
fieldset[disabled] .navbar-default .btn-link:hover,
.navbar-default .btn-link[disabled]:focus,
fieldset[disabled] .navbar-default .btn-link:focus {
  color: #ccc;
}
.navbar-inverse {
  background-color: #222;
  border-color: #080808;
}
.navbar-inverse .navbar-brand {
  color: #9d9d9d;
}
.navbar-inverse .navbar-brand:hover,
.navbar-inverse .navbar-brand:focus {
  color: #fff;
  background-color: transparent;
}
.navbar-inverse .navbar-text {
  color: #9d9d9d;
}
.navbar-inverse .navbar-nav > li > a {
  color: #9d9d9d;
}
.navbar-inverse .navbar-nav > li > a:hover,
.navbar-inverse .navbar-nav > li > a:focus {
  color: #fff;
  background-color: transparent;
}
.navbar-inverse .navbar-nav > .active > a,
.navbar-inverse .navbar-nav > .active > a:hover,
.navbar-inverse .navbar-nav > .active > a:focus {
  color: #fff;
  background-color: #080808;
}
.navbar-inverse .navbar-nav > .disabled > a,
.navbar-inverse .navbar-nav > .disabled > a:hover,
.navbar-inverse .navbar-nav > .disabled > a:focus {
  color: #444;
  background-color: transparent;
}
.navbar-inverse .navbar-toggle {
  border-color: #333;
}
.navbar-inverse .navbar-toggle:hover,
.navbar-inverse .navbar-toggle:focus {
  background-color: #333;
}
.navbar-inverse .navbar-toggle .icon-bar {
  background-color: #fff;
}
.navbar-inverse .navbar-collapse,
.navbar-inverse .navbar-form {
  border-color: #101010;
}
.navbar-inverse .navbar-nav > .open > a,
.navbar-inverse .navbar-nav > .open > a:hover,
.navbar-inverse .navbar-nav > .open > a:focus {
  background-color: #080808;
  color: #fff;
}
@media (max-width: 540px) {
  .navbar-inverse .navbar-nav .open .dropdown-menu > .dropdown-header {
    border-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu .divider {
    background-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a {
    color: #9d9d9d;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a:focus {
    color: #fff;
    background-color: transparent;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a:focus {
    color: #fff;
    background-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a:focus {
    color: #444;
    background-color: transparent;
  }
}
.navbar-inverse .navbar-link {
  color: #9d9d9d;
}
.navbar-inverse .navbar-link:hover {
  color: #fff;
}
.navbar-inverse .btn-link {
  color: #9d9d9d;
}
.navbar-inverse .btn-link:hover,
.navbar-inverse .btn-link:focus {
  color: #fff;
}
.navbar-inverse .btn-link[disabled]:hover,
fieldset[disabled] .navbar-inverse .btn-link:hover,
.navbar-inverse .btn-link[disabled]:focus,
fieldset[disabled] .navbar-inverse .btn-link:focus {
  color: #444;
}
.breadcrumb {
  padding: 8px 15px;
  margin-bottom: 18px;
  list-style: none;
  background-color: #f5f5f5;
  border-radius: 2px;
}
.breadcrumb > li {
  display: inline-block;
}
.breadcrumb > li + li:before {
  content: "/\00a0";
  padding: 0 5px;
  color: #5e5e5e;
}
.breadcrumb > .active {
  color: #777777;
}
.pagination {
  display: inline-block;
  padding-left: 0;
  margin: 18px 0;
  border-radius: 2px;
}
.pagination > li {
  display: inline;
}
.pagination > li > a,
.pagination > li > span {
  position: relative;
  float: left;
  padding: 6px 12px;
  line-height: 1.42857143;
  text-decoration: none;
  color: #337ab7;
  background-color: #fff;
  border: 1px solid #ddd;
  margin-left: -1px;
}
.pagination > li:first-child > a,
.pagination > li:first-child > span {
  margin-left: 0;
  border-bottom-left-radius: 2px;
  border-top-left-radius: 2px;
}
.pagination > li:last-child > a,
.pagination > li:last-child > span {
  border-bottom-right-radius: 2px;
  border-top-right-radius: 2px;
}
.pagination > li > a:hover,
.pagination > li > span:hover,
.pagination > li > a:focus,
.pagination > li > span:focus {
  z-index: 2;
  color: #23527c;
  background-color: #eeeeee;
  border-color: #ddd;
}
.pagination > .active > a,
.pagination > .active > span,
.pagination > .active > a:hover,
.pagination > .active > span:hover,
.pagination > .active > a:focus,
.pagination > .active > span:focus {
  z-index: 3;
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
  cursor: default;
}
.pagination > .disabled > span,
.pagination > .disabled > span:hover,
.pagination > .disabled > span:focus,
.pagination > .disabled > a,
.pagination > .disabled > a:hover,
.pagination > .disabled > a:focus {
  color: #777777;
  background-color: #fff;
  border-color: #ddd;
  cursor: not-allowed;
}
.pagination-lg > li > a,
.pagination-lg > li > span {
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
}
.pagination-lg > li:first-child > a,
.pagination-lg > li:first-child > span {
  border-bottom-left-radius: 3px;
  border-top-left-radius: 3px;
}
.pagination-lg > li:last-child > a,
.pagination-lg > li:last-child > span {
  border-bottom-right-radius: 3px;
  border-top-right-radius: 3px;
}
.pagination-sm > li > a,
.pagination-sm > li > span {
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
}
.pagination-sm > li:first-child > a,
.pagination-sm > li:first-child > span {
  border-bottom-left-radius: 1px;
  border-top-left-radius: 1px;
}
.pagination-sm > li:last-child > a,
.pagination-sm > li:last-child > span {
  border-bottom-right-radius: 1px;
  border-top-right-radius: 1px;
}
.pager {
  padding-left: 0;
  margin: 18px 0;
  list-style: none;
  text-align: center;
}
.pager li {
  display: inline;
}
.pager li > a,
.pager li > span {
  display: inline-block;
  padding: 5px 14px;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 15px;
}
.pager li > a:hover,
.pager li > a:focus {
  text-decoration: none;
  background-color: #eeeeee;
}
.pager .next > a,
.pager .next > span {
  float: right;
}
.pager .previous > a,
.pager .previous > span {
  float: left;
}
.pager .disabled > a,
.pager .disabled > a:hover,
.pager .disabled > a:focus,
.pager .disabled > span {
  color: #777777;
  background-color: #fff;
  cursor: not-allowed;
}
.label {
  display: inline;
  padding: .2em .6em .3em;
  font-size: 75%;
  font-weight: bold;
  line-height: 1;
  color: #fff;
  text-align: center;
  white-space: nowrap;
  vertical-align: baseline;
  border-radius: .25em;
}
a.label:hover,
a.label:focus {
  color: #fff;
  text-decoration: none;
  cursor: pointer;
}
.label:empty {
  display: none;
}
.btn .label {
  position: relative;
  top: -1px;
}
.label-default {
  background-color: #777777;
}
.label-default[href]:hover,
.label-default[href]:focus {
  background-color: #5e5e5e;
}
.label-primary {
  background-color: #337ab7;
}
.label-primary[href]:hover,
.label-primary[href]:focus {
  background-color: #286090;
}
.label-success {
  background-color: #5cb85c;
}
.label-success[href]:hover,
.label-success[href]:focus {
  background-color: #449d44;
}
.label-info {
  background-color: #5bc0de;
}
.label-info[href]:hover,
.label-info[href]:focus {
  background-color: #31b0d5;
}
.label-warning {
  background-color: #f0ad4e;
}
.label-warning[href]:hover,
.label-warning[href]:focus {
  background-color: #ec971f;
}
.label-danger {
  background-color: #d9534f;
}
.label-danger[href]:hover,
.label-danger[href]:focus {
  background-color: #c9302c;
}
.badge {
  display: inline-block;
  min-width: 10px;
  padding: 3px 7px;
  font-size: 12px;
  font-weight: bold;
  color: #fff;
  line-height: 1;
  vertical-align: middle;
  white-space: nowrap;
  text-align: center;
  background-color: #777777;
  border-radius: 10px;
}
.badge:empty {
  display: none;
}
.btn .badge {
  position: relative;
  top: -1px;
}
.btn-xs .badge,
.btn-group-xs > .btn .badge {
  top: 0;
  padding: 1px 5px;
}
a.badge:hover,
a.badge:focus {
  color: #fff;
  text-decoration: none;
  cursor: pointer;
}
.list-group-item.active > .badge,
.nav-pills > .active > a > .badge {
  color: #337ab7;
  background-color: #fff;
}
.list-group-item > .badge {
  float: right;
}
.list-group-item > .badge + .badge {
  margin-right: 5px;
}
.nav-pills > li > a > .badge {
  margin-left: 3px;
}
.jumbotron {
  padding-top: 30px;
  padding-bottom: 30px;
  margin-bottom: 30px;
  color: inherit;
  background-color: #eeeeee;
}
.jumbotron h1,
.jumbotron .h1 {
  color: inherit;
}
.jumbotron p {
  margin-bottom: 15px;
  font-size: 20px;
  font-weight: 200;
}
.jumbotron > hr {
  border-top-color: #d5d5d5;
}
.container .jumbotron,
.container-fluid .jumbotron {
  border-radius: 3px;
  padding-left: 0px;
  padding-right: 0px;
}
.jumbotron .container {
  max-width: 100%;
}
@media screen and (min-width: 768px) {
  .jumbotron {
    padding-top: 48px;
    padding-bottom: 48px;
  }
  .container .jumbotron,
  .container-fluid .jumbotron {
    padding-left: 60px;
    padding-right: 60px;
  }
  .jumbotron h1,
  .jumbotron .h1 {
    font-size: 59px;
  }
}
.thumbnail {
  display: block;
  padding: 4px;
  margin-bottom: 18px;
  line-height: 1.42857143;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 2px;
  -webkit-transition: border 0.2s ease-in-out;
  -o-transition: border 0.2s ease-in-out;
  transition: border 0.2s ease-in-out;
}
.thumbnail > img,
.thumbnail a > img {
  margin-left: auto;
  margin-right: auto;
}
a.thumbnail:hover,
a.thumbnail:focus,
a.thumbnail.active {
  border-color: #337ab7;
}
.thumbnail .caption {
  padding: 9px;
  color: #000;
}
.alert {
  padding: 15px;
  margin-bottom: 18px;
  border: 1px solid transparent;
  border-radius: 2px;
}
.alert h4 {
  margin-top: 0;
  color: inherit;
}
.alert .alert-link {
  font-weight: bold;
}
.alert > p,
.alert > ul {
  margin-bottom: 0;
}
.alert > p + p {
  margin-top: 5px;
}
.alert-dismissable,
.alert-dismissible {
  padding-right: 35px;
}
.alert-dismissable .close,
.alert-dismissible .close {
  position: relative;
  top: -2px;
  right: -21px;
  color: inherit;
}
.alert-success {
  background-color: #dff0d8;
  border-color: #d6e9c6;
  color: #3c763d;
}
.alert-success hr {
  border-top-color: #c9e2b3;
}
.alert-success .alert-link {
  color: #2b542c;
}
.alert-info {
  background-color: #d9edf7;
  border-color: #bce8f1;
  color: #31708f;
}
.alert-info hr {
  border-top-color: #a6e1ec;
}
.alert-info .alert-link {
  color: #245269;
}
.alert-warning {
  background-color: #fcf8e3;
  border-color: #faebcc;
  color: #8a6d3b;
}
.alert-warning hr {
  border-top-color: #f7e1b5;
}
.alert-warning .alert-link {
  color: #66512c;
}
.alert-danger {
  background-color: #f2dede;
  border-color: #ebccd1;
  color: #a94442;
}
.alert-danger hr {
  border-top-color: #e4b9c0;
}
.alert-danger .alert-link {
  color: #843534;
}
@-webkit-keyframes progress-bar-stripes {
  from {
    background-position: 40px 0;
  }
  to {
    background-position: 0 0;
  }
}
@keyframes progress-bar-stripes {
  from {
    background-position: 40px 0;
  }
  to {
    background-position: 0 0;
  }
}
.progress {
  overflow: hidden;
  height: 18px;
  margin-bottom: 18px;
  background-color: #f5f5f5;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.1);
  box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.1);
}
.progress-bar {
  float: left;
  width: 0%;
  height: 100%;
  font-size: 12px;
  line-height: 18px;
  color: #fff;
  text-align: center;
  background-color: #337ab7;
  -webkit-box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.15);
  box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.15);
  -webkit-transition: width 0.6s ease;
  -o-transition: width 0.6s ease;
  transition: width 0.6s ease;
}
.progress-striped .progress-bar,
.progress-bar-striped {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-size: 40px 40px;
}
.progress.active .progress-bar,
.progress-bar.active {
  -webkit-animation: progress-bar-stripes 2s linear infinite;
  -o-animation: progress-bar-stripes 2s linear infinite;
  animation: progress-bar-stripes 2s linear infinite;
}
.progress-bar-success {
  background-color: #5cb85c;
}
.progress-striped .progress-bar-success {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-info {
  background-color: #5bc0de;
}
.progress-striped .progress-bar-info {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-warning {
  background-color: #f0ad4e;
}
.progress-striped .progress-bar-warning {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-danger {
  background-color: #d9534f;
}
.progress-striped .progress-bar-danger {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.media {
  margin-top: 15px;
}
.media:first-child {
  margin-top: 0;
}
.media,
.media-body {
  zoom: 1;
  overflow: hidden;
}
.media-body {
  width: 10000px;
}
.media-object {
  display: block;
}
.media-object.img-thumbnail {
  max-width: none;
}
.media-right,
.media > .pull-right {
  padding-left: 10px;
}
.media-left,
.media > .pull-left {
  padding-right: 10px;
}
.media-left,
.media-right,
.media-body {
  display: table-cell;
  vertical-align: top;
}
.media-middle {
  vertical-align: middle;
}
.media-bottom {
  vertical-align: bottom;
}
.media-heading {
  margin-top: 0;
  margin-bottom: 5px;
}
.media-list {
  padding-left: 0;
  list-style: none;
}
.list-group {
  margin-bottom: 20px;
  padding-left: 0;
}
.list-group-item {
  position: relative;
  display: block;
  padding: 10px 15px;
  margin-bottom: -1px;
  background-color: #fff;
  border: 1px solid #ddd;
}
.list-group-item:first-child {
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
}
.list-group-item:last-child {
  margin-bottom: 0;
  border-bottom-right-radius: 2px;
  border-bottom-left-radius: 2px;
}
a.list-group-item,
button.list-group-item {
  color: #555;
}
a.list-group-item .list-group-item-heading,
button.list-group-item .list-group-item-heading {
  color: #333;
}
a.list-group-item:hover,
button.list-group-item:hover,
a.list-group-item:focus,
button.list-group-item:focus {
  text-decoration: none;
  color: #555;
  background-color: #f5f5f5;
}
button.list-group-item {
  width: 100%;
  text-align: left;
}
.list-group-item.disabled,
.list-group-item.disabled:hover,
.list-group-item.disabled:focus {
  background-color: #eeeeee;
  color: #777777;
  cursor: not-allowed;
}
.list-group-item.disabled .list-group-item-heading,
.list-group-item.disabled:hover .list-group-item-heading,
.list-group-item.disabled:focus .list-group-item-heading {
  color: inherit;
}
.list-group-item.disabled .list-group-item-text,
.list-group-item.disabled:hover .list-group-item-text,
.list-group-item.disabled:focus .list-group-item-text {
  color: #777777;
}
.list-group-item.active,
.list-group-item.active:hover,
.list-group-item.active:focus {
  z-index: 2;
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
}
.list-group-item.active .list-group-item-heading,
.list-group-item.active:hover .list-group-item-heading,
.list-group-item.active:focus .list-group-item-heading,
.list-group-item.active .list-group-item-heading > small,
.list-group-item.active:hover .list-group-item-heading > small,
.list-group-item.active:focus .list-group-item-heading > small,
.list-group-item.active .list-group-item-heading > .small,
.list-group-item.active:hover .list-group-item-heading > .small,
.list-group-item.active:focus .list-group-item-heading > .small {
  color: inherit;
}
.list-group-item.active .list-group-item-text,
.list-group-item.active:hover .list-group-item-text,
.list-group-item.active:focus .list-group-item-text {
  color: #c7ddef;
}
.list-group-item-success {
  color: #3c763d;
  background-color: #dff0d8;
}
a.list-group-item-success,
button.list-group-item-success {
  color: #3c763d;
}
a.list-group-item-success .list-group-item-heading,
button.list-group-item-success .list-group-item-heading {
  color: inherit;
}
a.list-group-item-success:hover,
button.list-group-item-success:hover,
a.list-group-item-success:focus,
button.list-group-item-success:focus {
  color: #3c763d;
  background-color: #d0e9c6;
}
a.list-group-item-success.active,
button.list-group-item-success.active,
a.list-group-item-success.active:hover,
button.list-group-item-success.active:hover,
a.list-group-item-success.active:focus,
button.list-group-item-success.active:focus {
  color: #fff;
  background-color: #3c763d;
  border-color: #3c763d;
}
.list-group-item-info {
  color: #31708f;
  background-color: #d9edf7;
}
a.list-group-item-info,
button.list-group-item-info {
  color: #31708f;
}
a.list-group-item-info .list-group-item-heading,
button.list-group-item-info .list-group-item-heading {
  color: inherit;
}
a.list-group-item-info:hover,
button.list-group-item-info:hover,
a.list-group-item-info:focus,
button.list-group-item-info:focus {
  color: #31708f;
  background-color: #c4e3f3;
}
a.list-group-item-info.active,
button.list-group-item-info.active,
a.list-group-item-info.active:hover,
button.list-group-item-info.active:hover,
a.list-group-item-info.active:focus,
button.list-group-item-info.active:focus {
  color: #fff;
  background-color: #31708f;
  border-color: #31708f;
}
.list-group-item-warning {
  color: #8a6d3b;
  background-color: #fcf8e3;
}
a.list-group-item-warning,
button.list-group-item-warning {
  color: #8a6d3b;
}
a.list-group-item-warning .list-group-item-heading,
button.list-group-item-warning .list-group-item-heading {
  color: inherit;
}
a.list-group-item-warning:hover,
button.list-group-item-warning:hover,
a.list-group-item-warning:focus,
button.list-group-item-warning:focus {
  color: #8a6d3b;
  background-color: #faf2cc;
}
a.list-group-item-warning.active,
button.list-group-item-warning.active,
a.list-group-item-warning.active:hover,
button.list-group-item-warning.active:hover,
a.list-group-item-warning.active:focus,
button.list-group-item-warning.active:focus {
  color: #fff;
  background-color: #8a6d3b;
  border-color: #8a6d3b;
}
.list-group-item-danger {
  color: #a94442;
  background-color: #f2dede;
}
a.list-group-item-danger,
button.list-group-item-danger {
  color: #a94442;
}
a.list-group-item-danger .list-group-item-heading,
button.list-group-item-danger .list-group-item-heading {
  color: inherit;
}
a.list-group-item-danger:hover,
button.list-group-item-danger:hover,
a.list-group-item-danger:focus,
button.list-group-item-danger:focus {
  color: #a94442;
  background-color: #ebcccc;
}
a.list-group-item-danger.active,
button.list-group-item-danger.active,
a.list-group-item-danger.active:hover,
button.list-group-item-danger.active:hover,
a.list-group-item-danger.active:focus,
button.list-group-item-danger.active:focus {
  color: #fff;
  background-color: #a94442;
  border-color: #a94442;
}
.list-group-item-heading {
  margin-top: 0;
  margin-bottom: 5px;
}
.list-group-item-text {
  margin-bottom: 0;
  line-height: 1.3;
}
.panel {
  margin-bottom: 18px;
  background-color: #fff;
  border: 1px solid transparent;
  border-radius: 2px;
  -webkit-box-shadow: 0 1px 1px rgba(0, 0, 0, 0.05);
  box-shadow: 0 1px 1px rgba(0, 0, 0, 0.05);
}
.panel-body {
  padding: 15px;
}
.panel-heading {
  padding: 10px 15px;
  border-bottom: 1px solid transparent;
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel-heading > .dropdown .dropdown-toggle {
  color: inherit;
}
.panel-title {
  margin-top: 0;
  margin-bottom: 0;
  font-size: 15px;
  color: inherit;
}
.panel-title > a,
.panel-title > small,
.panel-title > .small,
.panel-title > small > a,
.panel-title > .small > a {
  color: inherit;
}
.panel-footer {
  padding: 10px 15px;
  background-color: #f5f5f5;
  border-top: 1px solid #ddd;
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .list-group,
.panel > .panel-collapse > .list-group {
  margin-bottom: 0;
}
.panel > .list-group .list-group-item,
.panel > .panel-collapse > .list-group .list-group-item {
  border-width: 1px 0;
  border-radius: 0;
}
.panel > .list-group:first-child .list-group-item:first-child,
.panel > .panel-collapse > .list-group:first-child .list-group-item:first-child {
  border-top: 0;
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel > .list-group:last-child .list-group-item:last-child,
.panel > .panel-collapse > .list-group:last-child .list-group-item:last-child {
  border-bottom: 0;
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .panel-heading + .panel-collapse > .list-group .list-group-item:first-child {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.panel-heading + .list-group .list-group-item:first-child {
  border-top-width: 0;
}
.list-group + .panel-footer {
  border-top-width: 0;
}
.panel > .table,
.panel > .table-responsive > .table,
.panel > .panel-collapse > .table {
  margin-bottom: 0;
}
.panel > .table caption,
.panel > .table-responsive > .table caption,
.panel > .panel-collapse > .table caption {
  padding-left: 15px;
  padding-right: 15px;
}
.panel > .table:first-child,
.panel > .table-responsive:first-child > .table:first-child {
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child {
  border-top-left-radius: 1px;
  border-top-right-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child td:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child td:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child td:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child td:first-child,
.panel > .table:first-child > thead:first-child > tr:first-child th:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child th:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child th:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child th:first-child {
  border-top-left-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child td:last-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child td:last-child,
.panel > .table:first-child > tbody:first-child > tr:first-child td:last-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child td:last-child,
.panel > .table:first-child > thead:first-child > tr:first-child th:last-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child th:last-child,
.panel > .table:first-child > tbody:first-child > tr:first-child th:last-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child th:last-child {
  border-top-right-radius: 1px;
}
.panel > .table:last-child,
.panel > .table-responsive:last-child > .table:last-child {
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child {
  border-bottom-left-radius: 1px;
  border-bottom-right-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child td:first-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child td:first-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child td:first-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child td:first-child,
.panel > .table:last-child > tbody:last-child > tr:last-child th:first-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child th:first-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child th:first-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child th:first-child {
  border-bottom-left-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child td:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child td:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child td:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child td:last-child,
.panel > .table:last-child > tbody:last-child > tr:last-child th:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child th:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child th:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child th:last-child {
  border-bottom-right-radius: 1px;
}
.panel > .panel-body + .table,
.panel > .panel-body + .table-responsive,
.panel > .table + .panel-body,
.panel > .table-responsive + .panel-body {
  border-top: 1px solid #ddd;
}
.panel > .table > tbody:first-child > tr:first-child th,
.panel > .table > tbody:first-child > tr:first-child td {
  border-top: 0;
}
.panel > .table-bordered,
.panel > .table-responsive > .table-bordered {
  border: 0;
}
.panel > .table-bordered > thead > tr > th:first-child,
.panel > .table-responsive > .table-bordered > thead > tr > th:first-child,
.panel > .table-bordered > tbody > tr > th:first-child,
.panel > .table-responsive > .table-bordered > tbody > tr > th:first-child,
.panel > .table-bordered > tfoot > tr > th:first-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > th:first-child,
.panel > .table-bordered > thead > tr > td:first-child,
.panel > .table-responsive > .table-bordered > thead > tr > td:first-child,
.panel > .table-bordered > tbody > tr > td:first-child,
.panel > .table-responsive > .table-bordered > tbody > tr > td:first-child,
.panel > .table-bordered > tfoot > tr > td:first-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > td:first-child {
  border-left: 0;
}
.panel > .table-bordered > thead > tr > th:last-child,
.panel > .table-responsive > .table-bordered > thead > tr > th:last-child,
.panel > .table-bordered > tbody > tr > th:last-child,
.panel > .table-responsive > .table-bordered > tbody > tr > th:last-child,
.panel > .table-bordered > tfoot > tr > th:last-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > th:last-child,
.panel > .table-bordered > thead > tr > td:last-child,
.panel > .table-responsive > .table-bordered > thead > tr > td:last-child,
.panel > .table-bordered > tbody > tr > td:last-child,
.panel > .table-responsive > .table-bordered > tbody > tr > td:last-child,
.panel > .table-bordered > tfoot > tr > td:last-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > td:last-child {
  border-right: 0;
}
.panel > .table-bordered > thead > tr:first-child > td,
.panel > .table-responsive > .table-bordered > thead > tr:first-child > td,
.panel > .table-bordered > tbody > tr:first-child > td,
.panel > .table-responsive > .table-bordered > tbody > tr:first-child > td,
.panel > .table-bordered > thead > tr:first-child > th,
.panel > .table-responsive > .table-bordered > thead > tr:first-child > th,
.panel > .table-bordered > tbody > tr:first-child > th,
.panel > .table-responsive > .table-bordered > tbody > tr:first-child > th {
  border-bottom: 0;
}
.panel > .table-bordered > tbody > tr:last-child > td,
.panel > .table-responsive > .table-bordered > tbody > tr:last-child > td,
.panel > .table-bordered > tfoot > tr:last-child > td,
.panel > .table-responsive > .table-bordered > tfoot > tr:last-child > td,
.panel > .table-bordered > tbody > tr:last-child > th,
.panel > .table-responsive > .table-bordered > tbody > tr:last-child > th,
.panel > .table-bordered > tfoot > tr:last-child > th,
.panel > .table-responsive > .table-bordered > tfoot > tr:last-child > th {
  border-bottom: 0;
}
.panel > .table-responsive {
  border: 0;
  margin-bottom: 0;
}
.panel-group {
  margin-bottom: 18px;
}
.panel-group .panel {
  margin-bottom: 0;
  border-radius: 2px;
}
.panel-group .panel + .panel {
  margin-top: 5px;
}
.panel-group .panel-heading {
  border-bottom: 0;
}
.panel-group .panel-heading + .panel-collapse > .panel-body,
.panel-group .panel-heading + .panel-collapse > .list-group {
  border-top: 1px solid #ddd;
}
.panel-group .panel-footer {
  border-top: 0;
}
.panel-group .panel-footer + .panel-collapse .panel-body {
  border-bottom: 1px solid #ddd;
}
.panel-default {
  border-color: #ddd;
}
.panel-default > .panel-heading {
  color: #333333;
  background-color: #f5f5f5;
  border-color: #ddd;
}
.panel-default > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #ddd;
}
.panel-default > .panel-heading .badge {
  color: #f5f5f5;
  background-color: #333333;
}
.panel-default > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #ddd;
}
.panel-primary {
  border-color: #337ab7;
}
.panel-primary > .panel-heading {
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
}
.panel-primary > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #337ab7;
}
.panel-primary > .panel-heading .badge {
  color: #337ab7;
  background-color: #fff;
}
.panel-primary > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #337ab7;
}
.panel-success {
  border-color: #d6e9c6;
}
.panel-success > .panel-heading {
  color: #3c763d;
  background-color: #dff0d8;
  border-color: #d6e9c6;
}
.panel-success > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #d6e9c6;
}
.panel-success > .panel-heading .badge {
  color: #dff0d8;
  background-color: #3c763d;
}
.panel-success > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #d6e9c6;
}
.panel-info {
  border-color: #bce8f1;
}
.panel-info > .panel-heading {
  color: #31708f;
  background-color: #d9edf7;
  border-color: #bce8f1;
}
.panel-info > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #bce8f1;
}
.panel-info > .panel-heading .badge {
  color: #d9edf7;
  background-color: #31708f;
}
.panel-info > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #bce8f1;
}
.panel-warning {
  border-color: #faebcc;
}
.panel-warning > .panel-heading {
  color: #8a6d3b;
  background-color: #fcf8e3;
  border-color: #faebcc;
}
.panel-warning > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #faebcc;
}
.panel-warning > .panel-heading .badge {
  color: #fcf8e3;
  background-color: #8a6d3b;
}
.panel-warning > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #faebcc;
}
.panel-danger {
  border-color: #ebccd1;
}
.panel-danger > .panel-heading {
  color: #a94442;
  background-color: #f2dede;
  border-color: #ebccd1;
}
.panel-danger > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #ebccd1;
}
.panel-danger > .panel-heading .badge {
  color: #f2dede;
  background-color: #a94442;
}
.panel-danger > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #ebccd1;
}
.embed-responsive {
  position: relative;
  display: block;
  height: 0;
  padding: 0;
  overflow: hidden;
}
.embed-responsive .embed-responsive-item,
.embed-responsive iframe,
.embed-responsive embed,
.embed-responsive object,
.embed-responsive video {
  position: absolute;
  top: 0;
  left: 0;
  bottom: 0;
  height: 100%;
  width: 100%;
  border: 0;
}
.embed-responsive-16by9 {
  padding-bottom: 56.25%;
}
.embed-responsive-4by3 {
  padding-bottom: 75%;
}
.well {
  min-height: 20px;
  padding: 19px;
  margin-bottom: 20px;
  background-color: #f5f5f5;
  border: 1px solid #e3e3e3;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.05);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.05);
}
.well blockquote {
  border-color: #ddd;
  border-color: rgba(0, 0, 0, 0.15);
}
.well-lg {
  padding: 24px;
  border-radius: 3px;
}
.well-sm {
  padding: 9px;
  border-radius: 1px;
}
.close {
  float: right;
  font-size: 19.5px;
  font-weight: bold;
  line-height: 1;
  color: #000;
  text-shadow: 0 1px 0 #fff;
  opacity: 0.2;
  filter: alpha(opacity=20);
}
.close:hover,
.close:focus {
  color: #000;
  text-decoration: none;
  cursor: pointer;
  opacity: 0.5;
  filter: alpha(opacity=50);
}
button.close {
  padding: 0;
  cursor: pointer;
  background: transparent;
  border: 0;
  -webkit-appearance: none;
}
.modal-open {
  overflow: hidden;
}
.modal {
  display: none;
  overflow: hidden;
  position: fixed;
  top: 0;
  right: 0;
  bottom: 0;
  left: 0;
  z-index: 1050;
  -webkit-overflow-scrolling: touch;
  outline: 0;
}
.modal.fade .modal-dialog {
  -webkit-transform: translate(0, -25%);
  -ms-transform: translate(0, -25%);
  -o-transform: translate(0, -25%);
  transform: translate(0, -25%);
  -webkit-transition: -webkit-transform 0.3s ease-out;
  -moz-transition: -moz-transform 0.3s ease-out;
  -o-transition: -o-transform 0.3s ease-out;
  transition: transform 0.3s ease-out;
}
.modal.in .modal-dialog {
  -webkit-transform: translate(0, 0);
  -ms-transform: translate(0, 0);
  -o-transform: translate(0, 0);
  transform: translate(0, 0);
}
.modal-open .modal {
  overflow-x: hidden;
  overflow-y: auto;
}
.modal-dialog {
  position: relative;
  width: auto;
  margin: 10px;
}
.modal-content {
  position: relative;
  background-color: #fff;
  border: 1px solid #999;
  border: 1px solid rgba(0, 0, 0, 0.2);
  border-radius: 3px;
  -webkit-box-shadow: 0 3px 9px rgba(0, 0, 0, 0.5);
  box-shadow: 0 3px 9px rgba(0, 0, 0, 0.5);
  background-clip: padding-box;
  outline: 0;
}
.modal-backdrop {
  position: fixed;
  top: 0;
  right: 0;
  bottom: 0;
  left: 0;
  z-index: 1040;
  background-color: #000;
}
.modal-backdrop.fade {
  opacity: 0;
  filter: alpha(opacity=0);
}
.modal-backdrop.in {
  opacity: 0.5;
  filter: alpha(opacity=50);
}
.modal-header {
  padding: 15px;
  border-bottom: 1px solid #e5e5e5;
}
.modal-header .close {
  margin-top: -2px;
}
.modal-title {
  margin: 0;
  line-height: 1.42857143;
}
.modal-body {
  position: relative;
  padding: 15px;
}
.modal-footer {
  padding: 15px;
  text-align: right;
  border-top: 1px solid #e5e5e5;
}
.modal-footer .btn + .btn {
  margin-left: 5px;
  margin-bottom: 0;
}
.modal-footer .btn-group .btn + .btn {
  margin-left: -1px;
}
.modal-footer .btn-block + .btn-block {
  margin-left: 0;
}
.modal-scrollbar-measure {
  position: absolute;
  top: -9999px;
  width: 50px;
  height: 50px;
  overflow: scroll;
}
@media (min-width: 768px) {
  .modal-dialog {
    width: 600px;
    margin: 30px auto;
  }
  .modal-content {
    -webkit-box-shadow: 0 5px 15px rgba(0, 0, 0, 0.5);
    box-shadow: 0 5px 15px rgba(0, 0, 0, 0.5);
  }
  .modal-sm {
    width: 300px;
  }
}
@media (min-width: 992px) {
  .modal-lg {
    width: 900px;
  }
}
.tooltip {
  position: absolute;
  z-index: 1070;
  display: block;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-style: normal;
  font-weight: normal;
  letter-spacing: normal;
  line-break: auto;
  line-height: 1.42857143;
  text-align: left;
  text-align: start;
  text-decoration: none;
  text-shadow: none;
  text-transform: none;
  white-space: normal;
  word-break: normal;
  word-spacing: normal;
  word-wrap: normal;
  font-size: 12px;
  opacity: 0;
  filter: alpha(opacity=0);
}
.tooltip.in {
  opacity: 0.9;
  filter: alpha(opacity=90);
}
.tooltip.top {
  margin-top: -3px;
  padding: 5px 0;
}
.tooltip.right {
  margin-left: 3px;
  padding: 0 5px;
}
.tooltip.bottom {
  margin-top: 3px;
  padding: 5px 0;
}
.tooltip.left {
  margin-left: -3px;
  padding: 0 5px;
}
.tooltip-inner {
  max-width: 200px;
  padding: 3px 8px;
  color: #fff;
  text-align: center;
  background-color: #000;
  border-radius: 2px;
}
.tooltip-arrow {
  position: absolute;
  width: 0;
  height: 0;
  border-color: transparent;
  border-style: solid;
}
.tooltip.top .tooltip-arrow {
  bottom: 0;
  left: 50%;
  margin-left: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.top-left .tooltip-arrow {
  bottom: 0;
  right: 5px;
  margin-bottom: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.top-right .tooltip-arrow {
  bottom: 0;
  left: 5px;
  margin-bottom: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.right .tooltip-arrow {
  top: 50%;
  left: 0;
  margin-top: -5px;
  border-width: 5px 5px 5px 0;
  border-right-color: #000;
}
.tooltip.left .tooltip-arrow {
  top: 50%;
  right: 0;
  margin-top: -5px;
  border-width: 5px 0 5px 5px;
  border-left-color: #000;
}
.tooltip.bottom .tooltip-arrow {
  top: 0;
  left: 50%;
  margin-left: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.tooltip.bottom-left .tooltip-arrow {
  top: 0;
  right: 5px;
  margin-top: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.tooltip.bottom-right .tooltip-arrow {
  top: 0;
  left: 5px;
  margin-top: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.popover {
  position: absolute;
  top: 0;
  left: 0;
  z-index: 1060;
  display: none;
  max-width: 276px;
  padding: 1px;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-style: normal;
  font-weight: normal;
  letter-spacing: normal;
  line-break: auto;
  line-height: 1.42857143;
  text-align: left;
  text-align: start;
  text-decoration: none;
  text-shadow: none;
  text-transform: none;
  white-space: normal;
  word-break: normal;
  word-spacing: normal;
  word-wrap: normal;
  font-size: 13px;
  background-color: #fff;
  background-clip: padding-box;
  border: 1px solid #ccc;
  border: 1px solid rgba(0, 0, 0, 0.2);
  border-radius: 3px;
  -webkit-box-shadow: 0 5px 10px rgba(0, 0, 0, 0.2);
  box-shadow: 0 5px 10px rgba(0, 0, 0, 0.2);
}
.popover.top {
  margin-top: -10px;
}
.popover.right {
  margin-left: 10px;
}
.popover.bottom {
  margin-top: 10px;
}
.popover.left {
  margin-left: -10px;
}
.popover-title {
  margin: 0;
  padding: 8px 14px;
  font-size: 13px;
  background-color: #f7f7f7;
  border-bottom: 1px solid #ebebeb;
  border-radius: 2px 2px 0 0;
}
.popover-content {
  padding: 9px 14px;
}
.popover > .arrow,
.popover > .arrow:after {
  position: absolute;
  display: block;
  width: 0;
  height: 0;
  border-color: transparent;
  border-style: solid;
}
.popover > .arrow {
  border-width: 11px;
}
.popover > .arrow:after {
  border-width: 10px;
  content: "";
}
.popover.top > .arrow {
  left: 50%;
  margin-left: -11px;
  border-bottom-width: 0;
  border-top-color: #999999;
  border-top-color: rgba(0, 0, 0, 0.25);
  bottom: -11px;
}
.popover.top > .arrow:after {
  content: " ";
  bottom: 1px;
  margin-left: -10px;
  border-bottom-width: 0;
  border-top-color: #fff;
}
.popover.right > .arrow {
  top: 50%;
  left: -11px;
  margin-top: -11px;
  border-left-width: 0;
  border-right-color: #999999;
  border-right-color: rgba(0, 0, 0, 0.25);
}
.popover.right > .arrow:after {
  content: " ";
  left: 1px;
  bottom: -10px;
  border-left-width: 0;
  border-right-color: #fff;
}
.popover.bottom > .arrow {
  left: 50%;
  margin-left: -11px;
  border-top-width: 0;
  border-bottom-color: #999999;
  border-bottom-color: rgba(0, 0, 0, 0.25);
  top: -11px;
}
.popover.bottom > .arrow:after {
  content: " ";
  top: 1px;
  margin-left: -10px;
  border-top-width: 0;
  border-bottom-color: #fff;
}
.popover.left > .arrow {
  top: 50%;
  right: -11px;
  margin-top: -11px;
  border-right-width: 0;
  border-left-color: #999999;
  border-left-color: rgba(0, 0, 0, 0.25);
}
.popover.left > .arrow:after {
  content: " ";
  right: 1px;
  border-right-width: 0;
  border-left-color: #fff;
  bottom: -10px;
}
.carousel {
  position: relative;
}
.carousel-inner {
  position: relative;
  overflow: hidden;
  width: 100%;
}
.carousel-inner > .item {
  display: none;
  position: relative;
  -webkit-transition: 0.6s ease-in-out left;
  -o-transition: 0.6s ease-in-out left;
  transition: 0.6s ease-in-out left;
}
.carousel-inner > .item > img,
.carousel-inner > .item > a > img {
  line-height: 1;
}
@media all and (transform-3d), (-webkit-transform-3d) {
  .carousel-inner > .item {
    -webkit-transition: -webkit-transform 0.6s ease-in-out;
    -moz-transition: -moz-transform 0.6s ease-in-out;
    -o-transition: -o-transform 0.6s ease-in-out;
    transition: transform 0.6s ease-in-out;
    -webkit-backface-visibility: hidden;
    -moz-backface-visibility: hidden;
    backface-visibility: hidden;
    -webkit-perspective: 1000px;
    -moz-perspective: 1000px;
    perspective: 1000px;
  }
  .carousel-inner > .item.next,
  .carousel-inner > .item.active.right {
    -webkit-transform: translate3d(100%, 0, 0);
    transform: translate3d(100%, 0, 0);
    left: 0;
  }
  .carousel-inner > .item.prev,
  .carousel-inner > .item.active.left {
    -webkit-transform: translate3d(-100%, 0, 0);
    transform: translate3d(-100%, 0, 0);
    left: 0;
  }
  .carousel-inner > .item.next.left,
  .carousel-inner > .item.prev.right,
  .carousel-inner > .item.active {
    -webkit-transform: translate3d(0, 0, 0);
    transform: translate3d(0, 0, 0);
    left: 0;
  }
}
.carousel-inner > .active,
.carousel-inner > .next,
.carousel-inner > .prev {
  display: block;
}
.carousel-inner > .active {
  left: 0;
}
.carousel-inner > .next,
.carousel-inner > .prev {
  position: absolute;
  top: 0;
  width: 100%;
}
.carousel-inner > .next {
  left: 100%;
}
.carousel-inner > .prev {
  left: -100%;
}
.carousel-inner > .next.left,
.carousel-inner > .prev.right {
  left: 0;
}
.carousel-inner > .active.left {
  left: -100%;
}
.carousel-inner > .active.right {
  left: 100%;
}
.carousel-control {
  position: absolute;
  top: 0;
  left: 0;
  bottom: 0;
  width: 15%;
  opacity: 0.5;
  filter: alpha(opacity=50);
  font-size: 20px;
  color: #fff;
  text-align: center;
  text-shadow: 0 1px 2px rgba(0, 0, 0, 0.6);
  background-color: rgba(0, 0, 0, 0);
}
.carousel-control.left {
  background-image: -webkit-linear-gradient(left, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-image: -o-linear-gradient(left, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-image: linear-gradient(to right, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-repeat: repeat-x;
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#80000000', endColorstr='#00000000', GradientType=1);
}
.carousel-control.right {
  left: auto;
  right: 0;
  background-image: -webkit-linear-gradient(left, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-image: -o-linear-gradient(left, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-image: linear-gradient(to right, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-repeat: repeat-x;
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#00000000', endColorstr='#80000000', GradientType=1);
}
.carousel-control:hover,
.carousel-control:focus {
  outline: 0;
  color: #fff;
  text-decoration: none;
  opacity: 0.9;
  filter: alpha(opacity=90);
}
.carousel-control .icon-prev,
.carousel-control .icon-next,
.carousel-control .glyphicon-chevron-left,
.carousel-control .glyphicon-chevron-right {
  position: absolute;
  top: 50%;
  margin-top: -10px;
  z-index: 5;
  display: inline-block;
}
.carousel-control .icon-prev,
.carousel-control .glyphicon-chevron-left {
  left: 50%;
  margin-left: -10px;
}
.carousel-control .icon-next,
.carousel-control .glyphicon-chevron-right {
  right: 50%;
  margin-right: -10px;
}
.carousel-control .icon-prev,
.carousel-control .icon-next {
  width: 20px;
  height: 20px;
  line-height: 1;
  font-family: serif;
}
.carousel-control .icon-prev:before {
  content: '\2039';
}
.carousel-control .icon-next:before {
  content: '\203a';
}
.carousel-indicators {
  position: absolute;
  bottom: 10px;
  left: 50%;
  z-index: 15;
  width: 60%;
  margin-left: -30%;
  padding-left: 0;
  list-style: none;
  text-align: center;
}
.carousel-indicators li {
  display: inline-block;
  width: 10px;
  height: 10px;
  margin: 1px;
  text-indent: -999px;
  border: 1px solid #fff;
  border-radius: 10px;
  cursor: pointer;
  background-color: #000 \9;
  background-color: rgba(0, 0, 0, 0);
}
.carousel-indicators .active {
  margin: 0;
  width: 12px;
  height: 12px;
  background-color: #fff;
}
.carousel-caption {
  position: absolute;
  left: 15%;
  right: 15%;
  bottom: 20px;
  z-index: 10;
  padding-top: 20px;
  padding-bottom: 20px;
  color: #fff;
  text-align: center;
  text-shadow: 0 1px 2px rgba(0, 0, 0, 0.6);
}
.carousel-caption .btn {
  text-shadow: none;
}
@media screen and (min-width: 768px) {
  .carousel-control .glyphicon-chevron-left,
  .carousel-control .glyphicon-chevron-right,
  .carousel-control .icon-prev,
  .carousel-control .icon-next {
    width: 30px;
    height: 30px;
    margin-top: -10px;
    font-size: 30px;
  }
  .carousel-control .glyphicon-chevron-left,
  .carousel-control .icon-prev {
    margin-left: -10px;
  }
  .carousel-control .glyphicon-chevron-right,
  .carousel-control .icon-next {
    margin-right: -10px;
  }
  .carousel-caption {
    left: 20%;
    right: 20%;
    padding-bottom: 30px;
  }
  .carousel-indicators {
    bottom: 20px;
  }
}
.clearfix:before,
.clearfix:after,
.dl-horizontal dd:before,
.dl-horizontal dd:after,
.container:before,
.container:after,
.container-fluid:before,
.container-fluid:after,
.row:before,
.row:after,
.form-horizontal .form-group:before,
.form-horizontal .form-group:after,
.btn-toolbar:before,
.btn-toolbar:after,
.btn-group-vertical > .btn-group:before,
.btn-group-vertical > .btn-group:after,
.nav:before,
.nav:after,
.navbar:before,
.navbar:after,
.navbar-header:before,
.navbar-header:after,
.navbar-collapse:before,
.navbar-collapse:after,
.pager:before,
.pager:after,
.panel-body:before,
.panel-body:after,
.modal-header:before,
.modal-header:after,
.modal-footer:before,
.modal-footer:after,
.item_buttons:before,
.item_buttons:after {
  content: " ";
  display: table;
}
.clearfix:after,
.dl-horizontal dd:after,
.container:after,
.container-fluid:after,
.row:after,
.form-horizontal .form-group:after,
.btn-toolbar:after,
.btn-group-vertical > .btn-group:after,
.nav:after,
.navbar:after,
.navbar-header:after,
.navbar-collapse:after,
.pager:after,
.panel-body:after,
.modal-header:after,
.modal-footer:after,
.item_buttons:after {
  clear: both;
}
.center-block {
  display: block;
  margin-left: auto;
  margin-right: auto;
}
.pull-right {
  float: right !important;
}
.pull-left {
  float: left !important;
}
.hide {
  display: none !important;
}
.show {
  display: block !important;
}
.invisible {
  visibility: hidden;
}
.text-hide {
  font: 0/0 a;
  color: transparent;
  text-shadow: none;
  background-color: transparent;
  border: 0;
}
.hidden {
  display: none !important;
}
.affix {
  position: fixed;
}
@-ms-viewport {
  width: device-width;
}
.visible-xs,
.visible-sm,
.visible-md,
.visible-lg {
  display: none !important;
}
.visible-xs-block,
.visible-xs-inline,
.visible-xs-inline-block,
.visible-sm-block,
.visible-sm-inline,
.visible-sm-inline-block,
.visible-md-block,
.visible-md-inline,
.visible-md-inline-block,
.visible-lg-block,
.visible-lg-inline,
.visible-lg-inline-block {
  display: none !important;
}
@media (max-width: 767px) {
  .visible-xs {
    display: block !important;
  }
  table.visible-xs {
    display: table !important;
  }
  tr.visible-xs {
    display: table-row !important;
  }
  th.visible-xs,
  td.visible-xs {
    display: table-cell !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-block {
    display: block !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-inline {
    display: inline !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm {
    display: block !important;
  }
  table.visible-sm {
    display: table !important;
  }
  tr.visible-sm {
    display: table-row !important;
  }
  th.visible-sm,
  td.visible-sm {
    display: table-cell !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-block {
    display: block !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-inline {
    display: inline !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md {
    display: block !important;
  }
  table.visible-md {
    display: table !important;
  }
  tr.visible-md {
    display: table-row !important;
  }
  th.visible-md,
  td.visible-md {
    display: table-cell !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-block {
    display: block !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-inline {
    display: inline !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg {
    display: block !important;
  }
  table.visible-lg {
    display: table !important;
  }
  tr.visible-lg {
    display: table-row !important;
  }
  th.visible-lg,
  td.visible-lg {
    display: table-cell !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-block {
    display: block !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-inline {
    display: inline !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-inline-block {
    display: inline-block !important;
  }
}
@media (max-width: 767px) {
  .hidden-xs {
    display: none !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .hidden-sm {
    display: none !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .hidden-md {
    display: none !important;
  }
}
@media (min-width: 1200px) {
  .hidden-lg {
    display: none !important;
  }
}
.visible-print {
  display: none !important;
}
@media print {
  .visible-print {
    display: block !important;
  }
  table.visible-print {
    display: table !important;
  }
  tr.visible-print {
    display: table-row !important;
  }
  th.visible-print,
  td.visible-print {
    display: table-cell !important;
  }
}
.visible-print-block {
  display: none !important;
}
@media print {
  .visible-print-block {
    display: block !important;
  }
}
.visible-print-inline {
  display: none !important;
}
@media print {
  .visible-print-inline {
    display: inline !important;
  }
}
.visible-print-inline-block {
  display: none !important;
}
@media print {
  .visible-print-inline-block {
    display: inline-block !important;
  }
}
@media print {
  .hidden-print {
    display: none !important;
  }
}
/*!
*
* Font Awesome
*
*/
/*!
 *  Font Awesome 4.2.0 by @davegandy - http://fontawesome.io - @fontawesome
 *  License - http://fontawesome.io/license (Font: SIL OFL 1.1, CSS: MIT License)
 */
/* FONT PATH
 * -------------------------- */
@font-face {
  font-family: 'FontAwesome';
  src: url('../components/font-awesome/fonts/fontawesome-webfont.eot?v=4.2.0');
  src: url('../components/font-awesome/fonts/fontawesome-webfont.eot?#iefix&v=4.2.0') format('embedded-opentype'), url('../components/font-awesome/fonts/fontawesome-webfont.woff?v=4.2.0') format('woff'), url('../components/font-awesome/fonts/fontawesome-webfont.ttf?v=4.2.0') format('truetype'), url('../components/font-awesome/fonts/fontawesome-webfont.svg?v=4.2.0#fontawesomeregular') format('svg');
  font-weight: normal;
  font-style: normal;
}
.fa {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}
/* makes the font 33% larger relative to the icon container */
.fa-lg {
  font-size: 1.33333333em;
  line-height: 0.75em;
  vertical-align: -15%;
}
.fa-2x {
  font-size: 2em;
}
.fa-3x {
  font-size: 3em;
}
.fa-4x {
  font-size: 4em;
}
.fa-5x {
  font-size: 5em;
}
.fa-fw {
  width: 1.28571429em;
  text-align: center;
}
.fa-ul {
  padding-left: 0;
  margin-left: 2.14285714em;
  list-style-type: none;
}
.fa-ul > li {
  position: relative;
}
.fa-li {
  position: absolute;
  left: -2.14285714em;
  width: 2.14285714em;
  top: 0.14285714em;
  text-align: center;
}
.fa-li.fa-lg {
  left: -1.85714286em;
}
.fa-border {
  padding: .2em .25em .15em;
  border: solid 0.08em #eee;
  border-radius: .1em;
}
.pull-right {
  float: right;
}
.pull-left {
  float: left;
}
.fa.pull-left {
  margin-right: .3em;
}
.fa.pull-right {
  margin-left: .3em;
}
.fa-spin {
  -webkit-animation: fa-spin 2s infinite linear;
  animation: fa-spin 2s infinite linear;
}
@-webkit-keyframes fa-spin {
  0% {
    -webkit-transform: rotate(0deg);
    transform: rotate(0deg);
  }
  100% {
    -webkit-transform: rotate(359deg);
    transform: rotate(359deg);
  }
}
@keyframes fa-spin {
  0% {
    -webkit-transform: rotate(0deg);
    transform: rotate(0deg);
  }
  100% {
    -webkit-transform: rotate(359deg);
    transform: rotate(359deg);
  }
}
.fa-rotate-90 {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=1);
  -webkit-transform: rotate(90deg);
  -ms-transform: rotate(90deg);
  transform: rotate(90deg);
}
.fa-rotate-180 {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=2);
  -webkit-transform: rotate(180deg);
  -ms-transform: rotate(180deg);
  transform: rotate(180deg);
}
.fa-rotate-270 {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=3);
  -webkit-transform: rotate(270deg);
  -ms-transform: rotate(270deg);
  transform: rotate(270deg);
}
.fa-flip-horizontal {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=0, mirror=1);
  -webkit-transform: scale(-1, 1);
  -ms-transform: scale(-1, 1);
  transform: scale(-1, 1);
}
.fa-flip-vertical {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=2, mirror=1);
  -webkit-transform: scale(1, -1);
  -ms-transform: scale(1, -1);
  transform: scale(1, -1);
}
:root .fa-rotate-90,
:root .fa-rotate-180,
:root .fa-rotate-270,
:root .fa-flip-horizontal,
:root .fa-flip-vertical {
  filter: none;
}
.fa-stack {
  position: relative;
  display: inline-block;
  width: 2em;
  height: 2em;
  line-height: 2em;
  vertical-align: middle;
}
.fa-stack-1x,
.fa-stack-2x {
  position: absolute;
  left: 0;
  width: 100%;
  text-align: center;
}
.fa-stack-1x {
  line-height: inherit;
}
.fa-stack-2x {
  font-size: 2em;
}
.fa-inverse {
  color: #fff;
}
/* Font Awesome uses the Unicode Private Use Area (PUA) to ensure screen
   readers do not read off random characters that represent icons */
.fa-glass:before {
  content: "\f000";
}
.fa-music:before {
  content: "\f001";
}
.fa-search:before {
  content: "\f002";
}
.fa-envelope-o:before {
  content: "\f003";
}
.fa-heart:before {
  content: "\f004";
}
.fa-star:before {
  content: "\f005";
}
.fa-star-o:before {
  content: "\f006";
}
.fa-user:before {
  content: "\f007";
}
.fa-film:before {
  content: "\f008";
}
.fa-th-large:before {
  content: "\f009";
}
.fa-th:before {
  content: "\f00a";
}
.fa-th-list:before {
  content: "\f00b";
}
.fa-check:before {
  content: "\f00c";
}
.fa-remove:before,
.fa-close:before,
.fa-times:before {
  content: "\f00d";
}
.fa-search-plus:before {
  content: "\f00e";
}
.fa-search-minus:before {
  content: "\f010";
}
.fa-power-off:before {
  content: "\f011";
}
.fa-signal:before {
  content: "\f012";
}
.fa-gear:before,
.fa-cog:before {
  content: "\f013";
}
.fa-trash-o:before {
  content: "\f014";
}
.fa-home:before {
  content: "\f015";
}
.fa-file-o:before {
  content: "\f016";
}
.fa-clock-o:before {
  content: "\f017";
}
.fa-road:before {
  content: "\f018";
}
.fa-download:before {
  content: "\f019";
}
.fa-arrow-circle-o-down:before {
  content: "\f01a";
}
.fa-arrow-circle-o-up:before {
  content: "\f01b";
}
.fa-inbox:before {
  content: "\f01c";
}
.fa-play-circle-o:before {
  content: "\f01d";
}
.fa-rotate-right:before,
.fa-repeat:before {
  content: "\f01e";
}
.fa-refresh:before {
  content: "\f021";
}
.fa-list-alt:before {
  content: "\f022";
}
.fa-lock:before {
  content: "\f023";
}
.fa-flag:before {
  content: "\f024";
}
.fa-headphones:before {
  content: "\f025";
}
.fa-volume-off:before {
  content: "\f026";
}
.fa-volume-down:before {
  content: "\f027";
}
.fa-volume-up:before {
  content: "\f028";
}
.fa-qrcode:before {
  content: "\f029";
}
.fa-barcode:before {
  content: "\f02a";
}
.fa-tag:before {
  content: "\f02b";
}
.fa-tags:before {
  content: "\f02c";
}
.fa-book:before {
  content: "\f02d";
}
.fa-bookmark:before {
  content: "\f02e";
}
.fa-print:before {
  content: "\f02f";
}
.fa-camera:before {
  content: "\f030";
}
.fa-font:before {
  content: "\f031";
}
.fa-bold:before {
  content: "\f032";
}
.fa-italic:before {
  content: "\f033";
}
.fa-text-height:before {
  content: "\f034";
}
.fa-text-width:before {
  content: "\f035";
}
.fa-align-left:before {
  content: "\f036";
}
.fa-align-center:before {
  content: "\f037";
}
.fa-align-right:before {
  content: "\f038";
}
.fa-align-justify:before {
  content: "\f039";
}
.fa-list:before {
  content: "\f03a";
}
.fa-dedent:before,
.fa-outdent:before {
  content: "\f03b";
}
.fa-indent:before {
  content: "\f03c";
}
.fa-video-camera:before {
  content: "\f03d";
}
.fa-photo:before,
.fa-image:before,
.fa-picture-o:before {
  content: "\f03e";
}
.fa-pencil:before {
  content: "\f040";
}
.fa-map-marker:before {
  content: "\f041";
}
.fa-adjust:before {
  content: "\f042";
}
.fa-tint:before {
  content: "\f043";
}
.fa-edit:before,
.fa-pencil-square-o:before {
  content: "\f044";
}
.fa-share-square-o:before {
  content: "\f045";
}
.fa-check-square-o:before {
  content: "\f046";
}
.fa-arrows:before {
  content: "\f047";
}
.fa-step-backward:before {
  content: "\f048";
}
.fa-fast-backward:before {
  content: "\f049";
}
.fa-backward:before {
  content: "\f04a";
}
.fa-play:before {
  content: "\f04b";
}
.fa-pause:before {
  content: "\f04c";
}
.fa-stop:before {
  content: "\f04d";
}
.fa-forward:before {
  content: "\f04e";
}
.fa-fast-forward:before {
  content: "\f050";
}
.fa-step-forward:before {
  content: "\f051";
}
.fa-eject:before {
  content: "\f052";
}
.fa-chevron-left:before {
  content: "\f053";
}
.fa-chevron-right:before {
  content: "\f054";
}
.fa-plus-circle:before {
  content: "\f055";
}
.fa-minus-circle:before {
  content: "\f056";
}
.fa-times-circle:before {
  content: "\f057";
}
.fa-check-circle:before {
  content: "\f058";
}
.fa-question-circle:before {
  content: "\f059";
}
.fa-info-circle:before {
  content: "\f05a";
}
.fa-crosshairs:before {
  content: "\f05b";
}
.fa-times-circle-o:before {
  content: "\f05c";
}
.fa-check-circle-o:before {
  content: "\f05d";
}
.fa-ban:before {
  content: "\f05e";
}
.fa-arrow-left:before {
  content: "\f060";
}
.fa-arrow-right:before {
  content: "\f061";
}
.fa-arrow-up:before {
  content: "\f062";
}
.fa-arrow-down:before {
  content: "\f063";
}
.fa-mail-forward:before,
.fa-share:before {
  content: "\f064";
}
.fa-expand:before {
  content: "\f065";
}
.fa-compress:before {
  content: "\f066";
}
.fa-plus:before {
  content: "\f067";
}
.fa-minus:before {
  content: "\f068";
}
.fa-asterisk:before {
  content: "\f069";
}
.fa-exclamation-circle:before {
  content: "\f06a";
}
.fa-gift:before {
  content: "\f06b";
}
.fa-leaf:before {
  content: "\f06c";
}
.fa-fire:before {
  content: "\f06d";
}
.fa-eye:before {
  content: "\f06e";
}
.fa-eye-slash:before {
  content: "\f070";
}
.fa-warning:before,
.fa-exclamation-triangle:before {
  content: "\f071";
}
.fa-plane:before {
  content: "\f072";
}
.fa-calendar:before {
  content: "\f073";
}
.fa-random:before {
  content: "\f074";
}
.fa-comment:before {
  content: "\f075";
}
.fa-magnet:before {
  content: "\f076";
}
.fa-chevron-up:before {
  content: "\f077";
}
.fa-chevron-down:before {
  content: "\f078";
}
.fa-retweet:before {
  content: "\f079";
}
.fa-shopping-cart:before {
  content: "\f07a";
}
.fa-folder:before {
  content: "\f07b";
}
.fa-folder-open:before {
  content: "\f07c";
}
.fa-arrows-v:before {
  content: "\f07d";
}
.fa-arrows-h:before {
  content: "\f07e";
}
.fa-bar-chart-o:before,
.fa-bar-chart:before {
  content: "\f080";
}
.fa-twitter-square:before {
  content: "\f081";
}
.fa-facebook-square:before {
  content: "\f082";
}
.fa-camera-retro:before {
  content: "\f083";
}
.fa-key:before {
  content: "\f084";
}
.fa-gears:before,
.fa-cogs:before {
  content: "\f085";
}
.fa-comments:before {
  content: "\f086";
}
.fa-thumbs-o-up:before {
  content: "\f087";
}
.fa-thumbs-o-down:before {
  content: "\f088";
}
.fa-star-half:before {
  content: "\f089";
}
.fa-heart-o:before {
  content: "\f08a";
}
.fa-sign-out:before {
  content: "\f08b";
}
.fa-linkedin-square:before {
  content: "\f08c";
}
.fa-thumb-tack:before {
  content: "\f08d";
}
.fa-external-link:before {
  content: "\f08e";
}
.fa-sign-in:before {
  content: "\f090";
}
.fa-trophy:before {
  content: "\f091";
}
.fa-github-square:before {
  content: "\f092";
}
.fa-upload:before {
  content: "\f093";
}
.fa-lemon-o:before {
  content: "\f094";
}
.fa-phone:before {
  content: "\f095";
}
.fa-square-o:before {
  content: "\f096";
}
.fa-bookmark-o:before {
  content: "\f097";
}
.fa-phone-square:before {
  content: "\f098";
}
.fa-twitter:before {
  content: "\f099";
}
.fa-facebook:before {
  content: "\f09a";
}
.fa-github:before {
  content: "\f09b";
}
.fa-unlock:before {
  content: "\f09c";
}
.fa-credit-card:before {
  content: "\f09d";
}
.fa-rss:before {
  content: "\f09e";
}
.fa-hdd-o:before {
  content: "\f0a0";
}
.fa-bullhorn:before {
  content: "\f0a1";
}
.fa-bell:before {
  content: "\f0f3";
}
.fa-certificate:before {
  content: "\f0a3";
}
.fa-hand-o-right:before {
  content: "\f0a4";
}
.fa-hand-o-left:before {
  content: "\f0a5";
}
.fa-hand-o-up:before {
  content: "\f0a6";
}
.fa-hand-o-down:before {
  content: "\f0a7";
}
.fa-arrow-circle-left:before {
  content: "\f0a8";
}
.fa-arrow-circle-right:before {
  content: "\f0a9";
}
.fa-arrow-circle-up:before {
  content: "\f0aa";
}
.fa-arrow-circle-down:before {
  content: "\f0ab";
}
.fa-globe:before {
  content: "\f0ac";
}
.fa-wrench:before {
  content: "\f0ad";
}
.fa-tasks:before {
  content: "\f0ae";
}
.fa-filter:before {
  content: "\f0b0";
}
.fa-briefcase:before {
  content: "\f0b1";
}
.fa-arrows-alt:before {
  content: "\f0b2";
}
.fa-group:before,
.fa-users:before {
  content: "\f0c0";
}
.fa-chain:before,
.fa-link:before {
  content: "\f0c1";
}
.fa-cloud:before {
  content: "\f0c2";
}
.fa-flask:before {
  content: "\f0c3";
}
.fa-cut:before,
.fa-scissors:before {
  content: "\f0c4";
}
.fa-copy:before,
.fa-files-o:before {
  content: "\f0c5";
}
.fa-paperclip:before {
  content: "\f0c6";
}
.fa-save:before,
.fa-floppy-o:before {
  content: "\f0c7";
}
.fa-square:before {
  content: "\f0c8";
}
.fa-navicon:before,
.fa-reorder:before,
.fa-bars:before {
  content: "\f0c9";
}
.fa-list-ul:before {
  content: "\f0ca";
}
.fa-list-ol:before {
  content: "\f0cb";
}
.fa-strikethrough:before {
  content: "\f0cc";
}
.fa-underline:before {
  content: "\f0cd";
}
.fa-table:before {
  content: "\f0ce";
}
.fa-magic:before {
  content: "\f0d0";
}
.fa-truck:before {
  content: "\f0d1";
}
.fa-pinterest:before {
  content: "\f0d2";
}
.fa-pinterest-square:before {
  content: "\f0d3";
}
.fa-google-plus-square:before {
  content: "\f0d4";
}
.fa-google-plus:before {
  content: "\f0d5";
}
.fa-money:before {
  content: "\f0d6";
}
.fa-caret-down:before {
  content: "\f0d7";
}
.fa-caret-up:before {
  content: "\f0d8";
}
.fa-caret-left:before {
  content: "\f0d9";
}
.fa-caret-right:before {
  content: "\f0da";
}
.fa-columns:before {
  content: "\f0db";
}
.fa-unsorted:before,
.fa-sort:before {
  content: "\f0dc";
}
.fa-sort-down:before,
.fa-sort-desc:before {
  content: "\f0dd";
}
.fa-sort-up:before,
.fa-sort-asc:before {
  content: "\f0de";
}
.fa-envelope:before {
  content: "\f0e0";
}
.fa-linkedin:before {
  content: "\f0e1";
}
.fa-rotate-left:before,
.fa-undo:before {
  content: "\f0e2";
}
.fa-legal:before,
.fa-gavel:before {
  content: "\f0e3";
}
.fa-dashboard:before,
.fa-tachometer:before {
  content: "\f0e4";
}
.fa-comment-o:before {
  content: "\f0e5";
}
.fa-comments-o:before {
  content: "\f0e6";
}
.fa-flash:before,
.fa-bolt:before {
  content: "\f0e7";
}
.fa-sitemap:before {
  content: "\f0e8";
}
.fa-umbrella:before {
  content: "\f0e9";
}
.fa-paste:before,
.fa-clipboard:before {
  content: "\f0ea";
}
.fa-lightbulb-o:before {
  content: "\f0eb";
}
.fa-exchange:before {
  content: "\f0ec";
}
.fa-cloud-download:before {
  content: "\f0ed";
}
.fa-cloud-upload:before {
  content: "\f0ee";
}
.fa-user-md:before {
  content: "\f0f0";
}
.fa-stethoscope:before {
  content: "\f0f1";
}
.fa-suitcase:before {
  content: "\f0f2";
}
.fa-bell-o:before {
  content: "\f0a2";
}
.fa-coffee:before {
  content: "\f0f4";
}
.fa-cutlery:before {
  content: "\f0f5";
}
.fa-file-text-o:before {
  content: "\f0f6";
}
.fa-building-o:before {
  content: "\f0f7";
}
.fa-hospital-o:before {
  content: "\f0f8";
}
.fa-ambulance:before {
  content: "\f0f9";
}
.fa-medkit:before {
  content: "\f0fa";
}
.fa-fighter-jet:before {
  content: "\f0fb";
}
.fa-beer:before {
  content: "\f0fc";
}
.fa-h-square:before {
  content: "\f0fd";
}
.fa-plus-square:before {
  content: "\f0fe";
}
.fa-angle-double-left:before {
  content: "\f100";
}
.fa-angle-double-right:before {
  content: "\f101";
}
.fa-angle-double-up:before {
  content: "\f102";
}
.fa-angle-double-down:before {
  content: "\f103";
}
.fa-angle-left:before {
  content: "\f104";
}
.fa-angle-right:before {
  content: "\f105";
}
.fa-angle-up:before {
  content: "\f106";
}
.fa-angle-down:before {
  content: "\f107";
}
.fa-desktop:before {
  content: "\f108";
}
.fa-laptop:before {
  content: "\f109";
}
.fa-tablet:before {
  content: "\f10a";
}
.fa-mobile-phone:before,
.fa-mobile:before {
  content: "\f10b";
}
.fa-circle-o:before {
  content: "\f10c";
}
.fa-quote-left:before {
  content: "\f10d";
}
.fa-quote-right:before {
  content: "\f10e";
}
.fa-spinner:before {
  content: "\f110";
}
.fa-circle:before {
  content: "\f111";
}
.fa-mail-reply:before,
.fa-reply:before {
  content: "\f112";
}
.fa-github-alt:before {
  content: "\f113";
}
.fa-folder-o:before {
  content: "\f114";
}
.fa-folder-open-o:before {
  content: "\f115";
}
.fa-smile-o:before {
  content: "\f118";
}
.fa-frown-o:before {
  content: "\f119";
}
.fa-meh-o:before {
  content: "\f11a";
}
.fa-gamepad:before {
  content: "\f11b";
}
.fa-keyboard-o:before {
  content: "\f11c";
}
.fa-flag-o:before {
  content: "\f11d";
}
.fa-flag-checkered:before {
  content: "\f11e";
}
.fa-terminal:before {
  content: "\f120";
}
.fa-code:before {
  content: "\f121";
}
.fa-mail-reply-all:before,
.fa-reply-all:before {
  content: "\f122";
}
.fa-star-half-empty:before,
.fa-star-half-full:before,
.fa-star-half-o:before {
  content: "\f123";
}
.fa-location-arrow:before {
  content: "\f124";
}
.fa-crop:before {
  content: "\f125";
}
.fa-code-fork:before {
  content: "\f126";
}
.fa-unlink:before,
.fa-chain-broken:before {
  content: "\f127";
}
.fa-question:before {
  content: "\f128";
}
.fa-info:before {
  content: "\f129";
}
.fa-exclamation:before {
  content: "\f12a";
}
.fa-superscript:before {
  content: "\f12b";
}
.fa-subscript:before {
  content: "\f12c";
}
.fa-eraser:before {
  content: "\f12d";
}
.fa-puzzle-piece:before {
  content: "\f12e";
}
.fa-microphone:before {
  content: "\f130";
}
.fa-microphone-slash:before {
  content: "\f131";
}
.fa-shield:before {
  content: "\f132";
}
.fa-calendar-o:before {
  content: "\f133";
}
.fa-fire-extinguisher:before {
  content: "\f134";
}
.fa-rocket:before {
  content: "\f135";
}
.fa-maxcdn:before {
  content: "\f136";
}
.fa-chevron-circle-left:before {
  content: "\f137";
}
.fa-chevron-circle-right:before {
  content: "\f138";
}
.fa-chevron-circle-up:before {
  content: "\f139";
}
.fa-chevron-circle-down:before {
  content: "\f13a";
}
.fa-html5:before {
  content: "\f13b";
}
.fa-css3:before {
  content: "\f13c";
}
.fa-anchor:before {
  content: "\f13d";
}
.fa-unlock-alt:before {
  content: "\f13e";
}
.fa-bullseye:before {
  content: "\f140";
}
.fa-ellipsis-h:before {
  content: "\f141";
}
.fa-ellipsis-v:before {
  content: "\f142";
}
.fa-rss-square:before {
  content: "\f143";
}
.fa-play-circle:before {
  content: "\f144";
}
.fa-ticket:before {
  content: "\f145";
}
.fa-minus-square:before {
  content: "\f146";
}
.fa-minus-square-o:before {
  content: "\f147";
}
.fa-level-up:before {
  content: "\f148";
}
.fa-level-down:before {
  content: "\f149";
}
.fa-check-square:before {
  content: "\f14a";
}
.fa-pencil-square:before {
  content: "\f14b";
}
.fa-external-link-square:before {
  content: "\f14c";
}
.fa-share-square:before {
  content: "\f14d";
}
.fa-compass:before {
  content: "\f14e";
}
.fa-toggle-down:before,
.fa-caret-square-o-down:before {
  content: "\f150";
}
.fa-toggle-up:before,
.fa-caret-square-o-up:before {
  content: "\f151";
}
.fa-toggle-right:before,
.fa-caret-square-o-right:before {
  content: "\f152";
}
.fa-euro:before,
.fa-eur:before {
  content: "\f153";
}
.fa-gbp:before {
  content: "\f154";
}
.fa-dollar:before,
.fa-usd:before {
  content: "\f155";
}
.fa-rupee:before,
.fa-inr:before {
  content: "\f156";
}
.fa-cny:before,
.fa-rmb:before,
.fa-yen:before,
.fa-jpy:before {
  content: "\f157";
}
.fa-ruble:before,
.fa-rouble:before,
.fa-rub:before {
  content: "\f158";
}
.fa-won:before,
.fa-krw:before {
  content: "\f159";
}
.fa-bitcoin:before,
.fa-btc:before {
  content: "\f15a";
}
.fa-file:before {
  content: "\f15b";
}
.fa-file-text:before {
  content: "\f15c";
}
.fa-sort-alpha-asc:before {
  content: "\f15d";
}
.fa-sort-alpha-desc:before {
  content: "\f15e";
}
.fa-sort-amount-asc:before {
  content: "\f160";
}
.fa-sort-amount-desc:before {
  content: "\f161";
}
.fa-sort-numeric-asc:before {
  content: "\f162";
}
.fa-sort-numeric-desc:before {
  content: "\f163";
}
.fa-thumbs-up:before {
  content: "\f164";
}
.fa-thumbs-down:before {
  content: "\f165";
}
.fa-youtube-square:before {
  content: "\f166";
}
.fa-youtube:before {
  content: "\f167";
}
.fa-xing:before {
  content: "\f168";
}
.fa-xing-square:before {
  content: "\f169";
}
.fa-youtube-play:before {
  content: "\f16a";
}
.fa-dropbox:before {
  content: "\f16b";
}
.fa-stack-overflow:before {
  content: "\f16c";
}
.fa-instagram:before {
  content: "\f16d";
}
.fa-flickr:before {
  content: "\f16e";
}
.fa-adn:before {
  content: "\f170";
}
.fa-bitbucket:before {
  content: "\f171";
}
.fa-bitbucket-square:before {
  content: "\f172";
}
.fa-tumblr:before {
  content: "\f173";
}
.fa-tumblr-square:before {
  content: "\f174";
}
.fa-long-arrow-down:before {
  content: "\f175";
}
.fa-long-arrow-up:before {
  content: "\f176";
}
.fa-long-arrow-left:before {
  content: "\f177";
}
.fa-long-arrow-right:before {
  content: "\f178";
}
.fa-apple:before {
  content: "\f179";
}
.fa-windows:before {
  content: "\f17a";
}
.fa-android:before {
  content: "\f17b";
}
.fa-linux:before {
  content: "\f17c";
}
.fa-dribbble:before {
  content: "\f17d";
}
.fa-skype:before {
  content: "\f17e";
}
.fa-foursquare:before {
  content: "\f180";
}
.fa-trello:before {
  content: "\f181";
}
.fa-female:before {
  content: "\f182";
}
.fa-male:before {
  content: "\f183";
}
.fa-gittip:before {
  content: "\f184";
}
.fa-sun-o:before {
  content: "\f185";
}
.fa-moon-o:before {
  content: "\f186";
}
.fa-archive:before {
  content: "\f187";
}
.fa-bug:before {
  content: "\f188";
}
.fa-vk:before {
  content: "\f189";
}
.fa-weibo:before {
  content: "\f18a";
}
.fa-renren:before {
  content: "\f18b";
}
.fa-pagelines:before {
  content: "\f18c";
}
.fa-stack-exchange:before {
  content: "\f18d";
}
.fa-arrow-circle-o-right:before {
  content: "\f18e";
}
.fa-arrow-circle-o-left:before {
  content: "\f190";
}
.fa-toggle-left:before,
.fa-caret-square-o-left:before {
  content: "\f191";
}
.fa-dot-circle-o:before {
  content: "\f192";
}
.fa-wheelchair:before {
  content: "\f193";
}
.fa-vimeo-square:before {
  content: "\f194";
}
.fa-turkish-lira:before,
.fa-try:before {
  content: "\f195";
}
.fa-plus-square-o:before {
  content: "\f196";
}
.fa-space-shuttle:before {
  content: "\f197";
}
.fa-slack:before {
  content: "\f198";
}
.fa-envelope-square:before {
  content: "\f199";
}
.fa-wordpress:before {
  content: "\f19a";
}
.fa-openid:before {
  content: "\f19b";
}
.fa-institution:before,
.fa-bank:before,
.fa-university:before {
  content: "\f19c";
}
.fa-mortar-board:before,
.fa-graduation-cap:before {
  content: "\f19d";
}
.fa-yahoo:before {
  content: "\f19e";
}
.fa-google:before {
  content: "\f1a0";
}
.fa-reddit:before {
  content: "\f1a1";
}
.fa-reddit-square:before {
  content: "\f1a2";
}
.fa-stumbleupon-circle:before {
  content: "\f1a3";
}
.fa-stumbleupon:before {
  content: "\f1a4";
}
.fa-delicious:before {
  content: "\f1a5";
}
.fa-digg:before {
  content: "\f1a6";
}
.fa-pied-piper:before {
  content: "\f1a7";
}
.fa-pied-piper-alt:before {
  content: "\f1a8";
}
.fa-drupal:before {
  content: "\f1a9";
}
.fa-joomla:before {
  content: "\f1aa";
}
.fa-language:before {
  content: "\f1ab";
}
.fa-fax:before {
  content: "\f1ac";
}
.fa-building:before {
  content: "\f1ad";
}
.fa-child:before {
  content: "\f1ae";
}
.fa-paw:before {
  content: "\f1b0";
}
.fa-spoon:before {
  content: "\f1b1";
}
.fa-cube:before {
  content: "\f1b2";
}
.fa-cubes:before {
  content: "\f1b3";
}
.fa-behance:before {
  content: "\f1b4";
}
.fa-behance-square:before {
  content: "\f1b5";
}
.fa-steam:before {
  content: "\f1b6";
}
.fa-steam-square:before {
  content: "\f1b7";
}
.fa-recycle:before {
  content: "\f1b8";
}
.fa-automobile:before,
.fa-car:before {
  content: "\f1b9";
}
.fa-cab:before,
.fa-taxi:before {
  content: "\f1ba";
}
.fa-tree:before {
  content: "\f1bb";
}
.fa-spotify:before {
  content: "\f1bc";
}
.fa-deviantart:before {
  content: "\f1bd";
}
.fa-soundcloud:before {
  content: "\f1be";
}
.fa-database:before {
  content: "\f1c0";
}
.fa-file-pdf-o:before {
  content: "\f1c1";
}
.fa-file-word-o:before {
  content: "\f1c2";
}
.fa-file-excel-o:before {
  content: "\f1c3";
}
.fa-file-powerpoint-o:before {
  content: "\f1c4";
}
.fa-file-photo-o:before,
.fa-file-picture-o:before,
.fa-file-image-o:before {
  content: "\f1c5";
}
.fa-file-zip-o:before,
.fa-file-archive-o:before {
  content: "\f1c6";
}
.fa-file-sound-o:before,
.fa-file-audio-o:before {
  content: "\f1c7";
}
.fa-file-movie-o:before,
.fa-file-video-o:before {
  content: "\f1c8";
}
.fa-file-code-o:before {
  content: "\f1c9";
}
.fa-vine:before {
  content: "\f1ca";
}
.fa-codepen:before {
  content: "\f1cb";
}
.fa-jsfiddle:before {
  content: "\f1cc";
}
.fa-life-bouy:before,
.fa-life-buoy:before,
.fa-life-saver:before,
.fa-support:before,
.fa-life-ring:before {
  content: "\f1cd";
}
.fa-circle-o-notch:before {
  content: "\f1ce";
}
.fa-ra:before,
.fa-rebel:before {
  content: "\f1d0";
}
.fa-ge:before,
.fa-empire:before {
  content: "\f1d1";
}
.fa-git-square:before {
  content: "\f1d2";
}
.fa-git:before {
  content: "\f1d3";
}
.fa-hacker-news:before {
  content: "\f1d4";
}
.fa-tencent-weibo:before {
  content: "\f1d5";
}
.fa-qq:before {
  content: "\f1d6";
}
.fa-wechat:before,
.fa-weixin:before {
  content: "\f1d7";
}
.fa-send:before,
.fa-paper-plane:before {
  content: "\f1d8";
}
.fa-send-o:before,
.fa-paper-plane-o:before {
  content: "\f1d9";
}
.fa-history:before {
  content: "\f1da";
}
.fa-circle-thin:before {
  content: "\f1db";
}
.fa-header:before {
  content: "\f1dc";
}
.fa-paragraph:before {
  content: "\f1dd";
}
.fa-sliders:before {
  content: "\f1de";
}
.fa-share-alt:before {
  content: "\f1e0";
}
.fa-share-alt-square:before {
  content: "\f1e1";
}
.fa-bomb:before {
  content: "\f1e2";
}
.fa-soccer-ball-o:before,
.fa-futbol-o:before {
  content: "\f1e3";
}
.fa-tty:before {
  content: "\f1e4";
}
.fa-binoculars:before {
  content: "\f1e5";
}
.fa-plug:before {
  content: "\f1e6";
}
.fa-slideshare:before {
  content: "\f1e7";
}
.fa-twitch:before {
  content: "\f1e8";
}
.fa-yelp:before {
  content: "\f1e9";
}
.fa-newspaper-o:before {
  content: "\f1ea";
}
.fa-wifi:before {
  content: "\f1eb";
}
.fa-calculator:before {
  content: "\f1ec";
}
.fa-paypal:before {
  content: "\f1ed";
}
.fa-google-wallet:before {
  content: "\f1ee";
}
.fa-cc-visa:before {
  content: "\f1f0";
}
.fa-cc-mastercard:before {
  content: "\f1f1";
}
.fa-cc-discover:before {
  content: "\f1f2";
}
.fa-cc-amex:before {
  content: "\f1f3";
}
.fa-cc-paypal:before {
  content: "\f1f4";
}
.fa-cc-stripe:before {
  content: "\f1f5";
}
.fa-bell-slash:before {
  content: "\f1f6";
}
.fa-bell-slash-o:before {
  content: "\f1f7";
}
.fa-trash:before {
  content: "\f1f8";
}
.fa-copyright:before {
  content: "\f1f9";
}
.fa-at:before {
  content: "\f1fa";
}
.fa-eyedropper:before {
  content: "\f1fb";
}
.fa-paint-brush:before {
  content: "\f1fc";
}
.fa-birthday-cake:before {
  content: "\f1fd";
}
.fa-area-chart:before {
  content: "\f1fe";
}
.fa-pie-chart:before {
  content: "\f200";
}
.fa-line-chart:before {
  content: "\f201";
}
.fa-lastfm:before {
  content: "\f202";
}
.fa-lastfm-square:before {
  content: "\f203";
}
.fa-toggle-off:before {
  content: "\f204";
}
.fa-toggle-on:before {
  content: "\f205";
}
.fa-bicycle:before {
  content: "\f206";
}
.fa-bus:before {
  content: "\f207";
}
.fa-ioxhost:before {
  content: "\f208";
}
.fa-angellist:before {
  content: "\f209";
}
.fa-cc:before {
  content: "\f20a";
}
.fa-shekel:before,
.fa-sheqel:before,
.fa-ils:before {
  content: "\f20b";
}
.fa-meanpath:before {
  content: "\f20c";
}
/*!
*
* IPython base
*
*/
.modal.fade .modal-dialog {
  -webkit-transform: translate(0, 0);
  -ms-transform: translate(0, 0);
  -o-transform: translate(0, 0);
  transform: translate(0, 0);
}
code {
  color: #000;
}
pre {
  font-size: inherit;
  line-height: inherit;
}
label {
  font-weight: normal;
}
/* Make the page background atleast 100% the height of the view port */
/* Make the page itself atleast 70% the height of the view port */
.border-box-sizing {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
.corner-all {
  border-radius: 2px;
}
.no-padding {
  padding: 0px;
}
/* Flexible box model classes */
/* Taken from Alex Russell http://infrequently.org/2009/08/css-3-progress/ */
/* This file is a compatability layer.  It allows the usage of flexible box 
model layouts accross multiple browsers, including older browsers.  The newest,
universal implementation of the flexible box model is used when available (see
`Modern browsers` comments below).  Browsers that are known to implement this 
new spec completely include:

    Firefox 28.0+
    Chrome 29.0+
    Internet Explorer 11+ 
    Opera 17.0+

Browsers not listed, including Safari, are supported via the styling under the
`Old browsers` comments below.
*/
.hbox {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
.hbox > * {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
}
.vbox {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
.vbox > * {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
}
.hbox.reverse,
.vbox.reverse,
.reverse {
  /* Old browsers */
  -webkit-box-direction: reverse;
  -moz-box-direction: reverse;
  box-direction: reverse;
  /* Modern browsers */
  flex-direction: row-reverse;
}
.hbox.box-flex0,
.vbox.box-flex0,
.box-flex0 {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
  width: auto;
}
.hbox.box-flex1,
.vbox.box-flex1,
.box-flex1 {
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
.hbox.box-flex,
.vbox.box-flex,
.box-flex {
  /* Old browsers */
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
.hbox.box-flex2,
.vbox.box-flex2,
.box-flex2 {
  /* Old browsers */
  -webkit-box-flex: 2;
  -moz-box-flex: 2;
  box-flex: 2;
  /* Modern browsers */
  flex: 2;
}
.box-group1 {
  /*  Deprecated */
  -webkit-box-flex-group: 1;
  -moz-box-flex-group: 1;
  box-flex-group: 1;
}
.box-group2 {
  /* Deprecated */
  -webkit-box-flex-group: 2;
  -moz-box-flex-group: 2;
  box-flex-group: 2;
}
.hbox.start,
.vbox.start,
.start {
  /* Old browsers */
  -webkit-box-pack: start;
  -moz-box-pack: start;
  box-pack: start;
  /* Modern browsers */
  justify-content: flex-start;
}
.hbox.end,
.vbox.end,
.end {
  /* Old browsers */
  -webkit-box-pack: end;
  -moz-box-pack: end;
  box-pack: end;
  /* Modern browsers */
  justify-content: flex-end;
}
.hbox.center,
.vbox.center,
.center {
  /* Old browsers */
  -webkit-box-pack: center;
  -moz-box-pack: center;
  box-pack: center;
  /* Modern browsers */
  justify-content: center;
}
.hbox.baseline,
.vbox.baseline,
.baseline {
  /* Old browsers */
  -webkit-box-pack: baseline;
  -moz-box-pack: baseline;
  box-pack: baseline;
  /* Modern browsers */
  justify-content: baseline;
}
.hbox.stretch,
.vbox.stretch,
.stretch {
  /* Old browsers */
  -webkit-box-pack: stretch;
  -moz-box-pack: stretch;
  box-pack: stretch;
  /* Modern browsers */
  justify-content: stretch;
}
.hbox.align-start,
.vbox.align-start,
.align-start {
  /* Old browsers */
  -webkit-box-align: start;
  -moz-box-align: start;
  box-align: start;
  /* Modern browsers */
  align-items: flex-start;
}
.hbox.align-end,
.vbox.align-end,
.align-end {
  /* Old browsers */
  -webkit-box-align: end;
  -moz-box-align: end;
  box-align: end;
  /* Modern browsers */
  align-items: flex-end;
}
.hbox.align-center,
.vbox.align-center,
.align-center {
  /* Old browsers */
  -webkit-box-align: center;
  -moz-box-align: center;
  box-align: center;
  /* Modern browsers */
  align-items: center;
}
.hbox.align-baseline,
.vbox.align-baseline,
.align-baseline {
  /* Old browsers */
  -webkit-box-align: baseline;
  -moz-box-align: baseline;
  box-align: baseline;
  /* Modern browsers */
  align-items: baseline;
}
.hbox.align-stretch,
.vbox.align-stretch,
.align-stretch {
  /* Old browsers */
  -webkit-box-align: stretch;
  -moz-box-align: stretch;
  box-align: stretch;
  /* Modern browsers */
  align-items: stretch;
}
div.error {
  margin: 2em;
  text-align: center;
}
div.error > h1 {
  font-size: 500%;
  line-height: normal;
}
div.error > p {
  font-size: 200%;
  line-height: normal;
}
div.traceback-wrapper {
  text-align: left;
  max-width: 800px;
  margin: auto;
}
/**
 * Primary styles
 *
 * Author: Jupyter Development Team
 */
body {
  background-color: #fff;
  /* This makes sure that the body covers the entire window and needs to
       be in a different element than the display: box in wrapper below */
  position: absolute;
  left: 0px;
  right: 0px;
  top: 0px;
  bottom: 0px;
  overflow: visible;
}
body > #header {
  /* Initially hidden to prevent FLOUC */
  display: none;
  background-color: #fff;
  /* Display over codemirror */
  position: relative;
  z-index: 100;
}
body > #header #header-container {
  padding-bottom: 5px;
  padding-top: 5px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
body > #header .header-bar {
  width: 100%;
  height: 1px;
  background: #e7e7e7;
  margin-bottom: -1px;
}
@media print {
  body > #header {
    display: none !important;
  }
}
#header-spacer {
  width: 100%;
  visibility: hidden;
}
@media print {
  #header-spacer {
    display: none;
  }
}
#ipython_notebook {
  padding-left: 0px;
  padding-top: 1px;
  padding-bottom: 1px;
}
@media (max-width: 991px) {
  #ipython_notebook {
    margin-left: 10px;
  }
}
[dir="rtl"] #ipython_notebook {
  float: right !important;
}
#noscript {
  width: auto;
  padding-top: 16px;
  padding-bottom: 16px;
  text-align: center;
  font-size: 22px;
  color: red;
  font-weight: bold;
}
#ipython_notebook img {
  height: 28px;
}
#site {
  width: 100%;
  display: none;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  overflow: auto;
}
@media print {
  #site {
    height: auto !important;
  }
}
/* Smaller buttons */
.ui-button .ui-button-text {
  padding: 0.2em 0.8em;
  font-size: 77%;
}
input.ui-button {
  padding: 0.3em 0.9em;
}
span#login_widget {
  float: right;
}
span#login_widget > .button,
#logout {
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
span#login_widget > .button:focus,
#logout:focus,
span#login_widget > .button.focus,
#logout.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
span#login_widget > .button:hover,
#logout:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
span#login_widget > .button:active,
#logout:active,
span#login_widget > .button.active,
#logout.active,
.open > .dropdown-togglespan#login_widget > .button,
.open > .dropdown-toggle#logout {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
span#login_widget > .button:active:hover,
#logout:active:hover,
span#login_widget > .button.active:hover,
#logout.active:hover,
.open > .dropdown-togglespan#login_widget > .button:hover,
.open > .dropdown-toggle#logout:hover,
span#login_widget > .button:active:focus,
#logout:active:focus,
span#login_widget > .button.active:focus,
#logout.active:focus,
.open > .dropdown-togglespan#login_widget > .button:focus,
.open > .dropdown-toggle#logout:focus,
span#login_widget > .button:active.focus,
#logout:active.focus,
span#login_widget > .button.active.focus,
#logout.active.focus,
.open > .dropdown-togglespan#login_widget > .button.focus,
.open > .dropdown-toggle#logout.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
span#login_widget > .button:active,
#logout:active,
span#login_widget > .button.active,
#logout.active,
.open > .dropdown-togglespan#login_widget > .button,
.open > .dropdown-toggle#logout {
  background-image: none;
}
span#login_widget > .button.disabled:hover,
#logout.disabled:hover,
span#login_widget > .button[disabled]:hover,
#logout[disabled]:hover,
fieldset[disabled] span#login_widget > .button:hover,
fieldset[disabled] #logout:hover,
span#login_widget > .button.disabled:focus,
#logout.disabled:focus,
span#login_widget > .button[disabled]:focus,
#logout[disabled]:focus,
fieldset[disabled] span#login_widget > .button:focus,
fieldset[disabled] #logout:focus,
span#login_widget > .button.disabled.focus,
#logout.disabled.focus,
span#login_widget > .button[disabled].focus,
#logout[disabled].focus,
fieldset[disabled] span#login_widget > .button.focus,
fieldset[disabled] #logout.focus {
  background-color: #fff;
  border-color: #ccc;
}
span#login_widget > .button .badge,
#logout .badge {
  color: #fff;
  background-color: #333;
}
.nav-header {
  text-transform: none;
}
#header > span {
  margin-top: 10px;
}
.modal_stretch .modal-dialog {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  min-height: 80vh;
}
.modal_stretch .modal-dialog .modal-body {
  max-height: calc(100vh - 200px);
  overflow: auto;
  flex: 1;
}
@media (min-width: 768px) {
  .modal .modal-dialog {
    width: 700px;
  }
}
@media (min-width: 768px) {
  select.form-control {
    margin-left: 12px;
    margin-right: 12px;
  }
}
/*!
*
* IPython auth
*
*/
.center-nav {
  display: inline-block;
  margin-bottom: -4px;
}
/*!
*
* IPython tree view
*
*/
/* We need an invisible input field on top of the sentense*/
/* "Drag file onto the list ..." */
.alternate_upload {
  background-color: none;
  display: inline;
}
.alternate_upload.form {
  padding: 0;
  margin: 0;
}
.alternate_upload input.fileinput {
  text-align: center;
  vertical-align: middle;
  display: inline;
  opacity: 0;
  z-index: 2;
  width: 12ex;
  margin-right: -12ex;
}
.alternate_upload .btn-upload {
  height: 22px;
}
/**
 * Primary styles
 *
 * Author: Jupyter Development Team
 */
[dir="rtl"] #tabs li {
  float: right;
}
ul#tabs {
  margin-bottom: 4px;
}
[dir="rtl"] ul#tabs {
  margin-right: 0px;
}
ul#tabs a {
  padding-top: 6px;
  padding-bottom: 4px;
}
ul.breadcrumb a:focus,
ul.breadcrumb a:hover {
  text-decoration: none;
}
ul.breadcrumb i.icon-home {
  font-size: 16px;
  margin-right: 4px;
}
ul.breadcrumb span {
  color: #5e5e5e;
}
.list_toolbar {
  padding: 4px 0 4px 0;
  vertical-align: middle;
}
.list_toolbar .tree-buttons {
  padding-top: 1px;
}
[dir="rtl"] .list_toolbar .tree-buttons {
  float: left !important;
}
[dir="rtl"] .list_toolbar .pull-right {
  padding-top: 1px;
  float: left !important;
}
[dir="rtl"] .list_toolbar .pull-left {
  float: right !important;
}
.dynamic-buttons {
  padding-top: 3px;
  display: inline-block;
}
.list_toolbar [class*="span"] {
  min-height: 24px;
}
.list_header {
  font-weight: bold;
  background-color: #EEE;
}
.list_placeholder {
  font-weight: bold;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
}
.list_container {
  margin-top: 4px;
  margin-bottom: 20px;
  border: 1px solid #ddd;
  border-radius: 2px;
}
.list_container > div {
  border-bottom: 1px solid #ddd;
}
.list_container > div:hover .list-item {
  background-color: red;
}
.list_container > div:last-child {
  border: none;
}
.list_item:hover .list_item {
  background-color: #ddd;
}
.list_item a {
  text-decoration: none;
}
.list_item:hover {
  background-color: #fafafa;
}
.list_header > div,
.list_item > div {
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
  line-height: 22px;
}
.list_header > div input,
.list_item > div input {
  margin-right: 7px;
  margin-left: 14px;
  vertical-align: baseline;
  line-height: 22px;
  position: relative;
  top: -1px;
}
.list_header > div .item_link,
.list_item > div .item_link {
  margin-left: -1px;
  vertical-align: baseline;
  line-height: 22px;
}
.new-file input[type=checkbox] {
  visibility: hidden;
}
.item_name {
  line-height: 22px;
  height: 24px;
}
.item_icon {
  font-size: 14px;
  color: #5e5e5e;
  margin-right: 7px;
  margin-left: 7px;
  line-height: 22px;
  vertical-align: baseline;
}
.item_buttons {
  line-height: 1em;
  margin-left: -5px;
}
.item_buttons .btn,
.item_buttons .btn-group,
.item_buttons .input-group {
  float: left;
}
.item_buttons > .btn,
.item_buttons > .btn-group,
.item_buttons > .input-group {
  margin-left: 5px;
}
.item_buttons .btn {
  min-width: 13ex;
}
.item_buttons .running-indicator {
  padding-top: 4px;
  color: #5cb85c;
}
.item_buttons .kernel-name {
  padding-top: 4px;
  color: #5bc0de;
  margin-right: 7px;
  float: left;
}
.toolbar_info {
  height: 24px;
  line-height: 24px;
}
.list_item input:not([type=checkbox]) {
  padding-top: 3px;
  padding-bottom: 3px;
  height: 22px;
  line-height: 14px;
  margin: 0px;
}
.highlight_text {
  color: blue;
}
#project_name {
  display: inline-block;
  padding-left: 7px;
  margin-left: -2px;
}
#project_name > .breadcrumb {
  padding: 0px;
  margin-bottom: 0px;
  background-color: transparent;
  font-weight: bold;
}
#tree-selector {
  padding-right: 0px;
}
[dir="rtl"] #tree-selector a {
  float: right;
}
#button-select-all {
  min-width: 50px;
}
#select-all {
  margin-left: 7px;
  margin-right: 2px;
}
.menu_icon {
  margin-right: 2px;
}
.tab-content .row {
  margin-left: 0px;
  margin-right: 0px;
}
.folder_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f114";
}
.folder_icon:before.pull-left {
  margin-right: .3em;
}
.folder_icon:before.pull-right {
  margin-left: .3em;
}
.notebook_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f02d";
  position: relative;
  top: -1px;
}
.notebook_icon:before.pull-left {
  margin-right: .3em;
}
.notebook_icon:before.pull-right {
  margin-left: .3em;
}
.running_notebook_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f02d";
  position: relative;
  top: -1px;
  color: #5cb85c;
}
.running_notebook_icon:before.pull-left {
  margin-right: .3em;
}
.running_notebook_icon:before.pull-right {
  margin-left: .3em;
}
.file_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f016";
  position: relative;
  top: -2px;
}
.file_icon:before.pull-left {
  margin-right: .3em;
}
.file_icon:before.pull-right {
  margin-left: .3em;
}
#notebook_toolbar .pull-right {
  padding-top: 0px;
  margin-right: -1px;
}
ul#new-menu {
  left: auto;
  right: 0;
}
[dir="rtl"] #new-menu {
  text-align: right;
}
.kernel-menu-icon {
  padding-right: 12px;
  width: 24px;
  content: "\f096";
}
.kernel-menu-icon:before {
  content: "\f096";
}
.kernel-menu-icon-current:before {
  content: "\f00c";
}
#tab_content {
  padding-top: 20px;
}
#running .panel-group .panel {
  margin-top: 3px;
  margin-bottom: 1em;
}
#running .panel-group .panel .panel-heading {
  background-color: #EEE;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
  line-height: 22px;
}
#running .panel-group .panel .panel-heading a:focus,
#running .panel-group .panel .panel-heading a:hover {
  text-decoration: none;
}
#running .panel-group .panel .panel-body {
  padding: 0px;
}
#running .panel-group .panel .panel-body .list_container {
  margin-top: 0px;
  margin-bottom: 0px;
  border: 0px;
  border-radius: 0px;
}
#running .panel-group .panel .panel-body .list_container .list_item {
  border-bottom: 1px solid #ddd;
}
#running .panel-group .panel .panel-body .list_container .list_item:last-child {
  border-bottom: 0px;
}
[dir="rtl"] #running .col-sm-8 {
  float: right !important;
}
.delete-button {
  display: none;
}
.duplicate-button {
  display: none;
}
.rename-button {
  display: none;
}
.shutdown-button {
  display: none;
}
.dynamic-instructions {
  display: inline-block;
  padding-top: 4px;
}
/*!
*
* IPython text editor webapp
*
*/
.selected-keymap i.fa {
  padding: 0px 5px;
}
.selected-keymap i.fa:before {
  content: "\f00c";
}
#mode-menu {
  overflow: auto;
  max-height: 20em;
}
.edit_app #header {
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
}
.edit_app #menubar .navbar {
  /* Use a negative 1 bottom margin, so the border overlaps the border of the
    header */
  margin-bottom: -1px;
}
.dirty-indicator {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator.pull-left {
  margin-right: .3em;
}
.dirty-indicator.pull-right {
  margin-left: .3em;
}
.dirty-indicator-dirty {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator-dirty.pull-left {
  margin-right: .3em;
}
.dirty-indicator-dirty.pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator-clean.pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean.pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f00c";
}
.dirty-indicator-clean:before.pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean:before.pull-right {
  margin-left: .3em;
}
#filename {
  font-size: 16pt;
  display: table;
  padding: 0px 5px;
}
#current-mode {
  padding-left: 5px;
  padding-right: 5px;
}
#texteditor-backdrop {
  padding-top: 20px;
  padding-bottom: 20px;
}
@media not print {
  #texteditor-backdrop {
    background-color: #EEE;
  }
}
@media print {
  #texteditor-backdrop #texteditor-container .CodeMirror-gutter,
  #texteditor-backdrop #texteditor-container .CodeMirror-gutters {
    background-color: #fff;
  }
}
@media not print {
  #texteditor-backdrop #texteditor-container .CodeMirror-gutter,
  #texteditor-backdrop #texteditor-container .CodeMirror-gutters {
    background-color: #fff;
  }
}
@media not print {
  #texteditor-backdrop #texteditor-container {
    padding: 0px;
    background-color: #fff;
    -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
    box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  }
}
/*!
*
* IPython notebook
*
*/
/* CSS font colors for translated ANSI colors. */
.ansibold {
  font-weight: bold;
}
/* use dark versions for foreground, to improve visibility */
.ansiblack {
  color: black;
}
.ansired {
  color: darkred;
}
.ansigreen {
  color: darkgreen;
}
.ansiyellow {
  color: #c4a000;
}
.ansiblue {
  color: darkblue;
}
.ansipurple {
  color: darkviolet;
}
.ansicyan {
  color: steelblue;
}
.ansigray {
  color: gray;
}
/* and light for background, for the same reason */
.ansibgblack {
  background-color: black;
}
.ansibgred {
  background-color: red;
}
.ansibggreen {
  background-color: green;
}
.ansibgyellow {
  background-color: yellow;
}
.ansibgblue {
  background-color: blue;
}
.ansibgpurple {
  background-color: magenta;
}
.ansibgcyan {
  background-color: cyan;
}
.ansibggray {
  background-color: gray;
}
div.cell {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  border-radius: 2px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  border-width: 1px;
  border-style: solid;
  border-color: transparent;
  width: 100%;
  padding: 5px;
  /* This acts as a spacer between cells, that is outside the border */
  margin: 0px;
  outline: none;
  border-left-width: 1px;
  padding-left: 5px;
  background: linear-gradient(to right, transparent -40px, transparent 1px, transparent 1px, transparent 100%);
}
div.cell.jupyter-soft-selected {
  border-left-color: #90CAF9;
  border-left-color: #E3F2FD;
  border-left-width: 1px;
  padding-left: 5px;
  border-right-color: #E3F2FD;
  border-right-width: 1px;
  background: #E3F2FD;
}
@media print {
  div.cell.jupyter-soft-selected {
    border-color: transparent;
  }
}
div.cell.selected {
  border-color: #ababab;
  border-left-width: 0px;
  padding-left: 6px;
  background: linear-gradient(to right, #42A5F5 -40px, #42A5F5 5px, transparent 5px, transparent 100%);
}
@media print {
  div.cell.selected {
    border-color: transparent;
  }
}
div.cell.selected.jupyter-soft-selected {
  border-left-width: 0;
  padding-left: 6px;
  background: linear-gradient(to right, #42A5F5 -40px, #42A5F5 7px, #E3F2FD 7px, #E3F2FD 100%);
}
.edit_mode div.cell.selected {
  border-color: #66BB6A;
  border-left-width: 0px;
  padding-left: 6px;
  background: linear-gradient(to right, #66BB6A -40px, #66BB6A 5px, transparent 5px, transparent 100%);
}
@media print {
  .edit_mode div.cell.selected {
    border-color: transparent;
  }
}
.prompt {
  /* This needs to be wide enough for 3 digit prompt numbers: In[100]: */
  min-width: 14ex;
  /* This padding is tuned to match the padding on the CodeMirror editor. */
  padding: 0.4em;
  margin: 0px;
  font-family: monospace;
  text-align: right;
  /* This has to match that of the the CodeMirror class line-height below */
  line-height: 1.21429em;
  /* Don't highlight prompt number selection */
  -webkit-touch-callout: none;
  -webkit-user-select: none;
  -khtml-user-select: none;
  -moz-user-select: none;
  -ms-user-select: none;
  user-select: none;
  /* Use default cursor */
  cursor: default;
}
@media (max-width: 540px) {
  .prompt {
    text-align: left;
  }
}
div.inner_cell {
  min-width: 0;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
/* input_area and input_prompt must match in top border and margin for alignment */
div.input_area {
  border: 1px solid #cfcfcf;
  border-radius: 2px;
  background: #f7f7f7;
  line-height: 1.21429em;
}
/* This is needed so that empty prompt areas can collapse to zero height when there
   is no content in the output_subarea and the prompt. The main purpose of this is
   to make sure that empty JavaScript output_subareas have no height. */
div.prompt:empty {
  padding-top: 0;
  padding-bottom: 0;
}
div.unrecognized_cell {
  padding: 5px 5px 5px 0px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
div.unrecognized_cell .inner_cell {
  border-radius: 2px;
  padding: 5px;
  font-weight: bold;
  color: red;
  border: 1px solid #cfcfcf;
  background: #eaeaea;
}
div.unrecognized_cell .inner_cell a {
  color: inherit;
  text-decoration: none;
}
div.unrecognized_cell .inner_cell a:hover {
  color: inherit;
  text-decoration: none;
}
@media (max-width: 540px) {
  div.unrecognized_cell > div.prompt {
    display: none;
  }
}
div.code_cell {
  /* avoid page breaking on code cells when printing */
}
@media print {
  div.code_cell {
    page-break-inside: avoid;
  }
}
/* any special styling for code cells that are currently running goes here */
div.input {
  page-break-inside: avoid;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.input {
    /* Old browsers */
    display: -webkit-box;
    -webkit-box-orient: vertical;
    -webkit-box-align: stretch;
    display: -moz-box;
    -moz-box-orient: vertical;
    -moz-box-align: stretch;
    display: box;
    box-orient: vertical;
    box-align: stretch;
    /* Modern browsers */
    display: flex;
    flex-direction: column;
    align-items: stretch;
  }
}
/* input_area and input_prompt must match in top border and margin for alignment */
div.input_prompt {
  color: #303F9F;
  border-top: 1px solid transparent;
}
div.input_area > div.highlight {
  margin: 0.4em;
  border: none;
  padding: 0px;
  background-color: transparent;
}
div.input_area > div.highlight > pre {
  margin: 0px;
  border: none;
  padding: 0px;
  background-color: transparent;
}
/* The following gets added to the <head> if it is detected that the user has a
 * monospace font with inconsistent normal/bold/italic height.  See
 * notebookmain.js.  Such fonts will have keywords vertically offset with
 * respect to the rest of the text.  The user should select a better font.
 * See: https://github.com/ipython/ipython/issues/1503
 *
 * .CodeMirror span {
 *      vertical-align: bottom;
 * }
 */
.CodeMirror {
  line-height: 1.21429em;
  /* Changed from 1em to our global default */
  font-size: 14px;
  height: auto;
  /* Changed to auto to autogrow */
  background: none;
  /* Changed from white to allow our bg to show through */
}
.CodeMirror-scroll {
  /*  The CodeMirror docs are a bit fuzzy on if overflow-y should be hidden or visible.*/
  /*  We have found that if it is visible, vertical scrollbars appear with font size changes.*/
  overflow-y: hidden;
  overflow-x: auto;
}
.CodeMirror-lines {
  /* In CM2, this used to be 0.4em, but in CM3 it went to 4px. We need the em value because */
  /* we have set a different line-height and want this to scale with that. */
  padding: 0.4em;
}
.CodeMirror-linenumber {
  padding: 0 8px 0 4px;
}
.CodeMirror-gutters {
  border-bottom-left-radius: 2px;
  border-top-left-radius: 2px;
}
.CodeMirror pre {
  /* In CM3 this went to 4px from 0 in CM2. We need the 0 value because of how we size */
  /* .CodeMirror-lines */
  padding: 0;
  border: 0;
  border-radius: 0;
}
/*

Original style from softwaremaniacs.org (c) Ivan Sagalaev <Maniac@SoftwareManiacs.Org>
Adapted from GitHub theme

*/
.highlight-base {
  color: #000;
}
.highlight-variable {
  color: #000;
}
.highlight-variable-2 {
  color: #1a1a1a;
}
.highlight-variable-3 {
  color: #333333;
}
.highlight-string {
  color: #BA2121;
}
.highlight-comment {
  color: #408080;
  font-style: italic;
}
.highlight-number {
  color: #080;
}
.highlight-atom {
  color: #88F;
}
.highlight-keyword {
  color: #008000;
  font-weight: bold;
}
.highlight-builtin {
  color: #008000;
}
.highlight-error {
  color: #f00;
}
.highlight-operator {
  color: #AA22FF;
  font-weight: bold;
}
.highlight-meta {
  color: #AA22FF;
}
/* previously not defined, copying from default codemirror */
.highlight-def {
  color: #00f;
}
.highlight-string-2 {
  color: #f50;
}
.highlight-qualifier {
  color: #555;
}
.highlight-bracket {
  color: #997;
}
.highlight-tag {
  color: #170;
}
.highlight-attribute {
  color: #00c;
}
.highlight-header {
  color: blue;
}
.highlight-quote {
  color: #090;
}
.highlight-link {
  color: #00c;
}
/* apply the same style to codemirror */
.cm-s-ipython span.cm-keyword {
  color: #008000;
  font-weight: bold;
}
.cm-s-ipython span.cm-atom {
  color: #88F;
}
.cm-s-ipython span.cm-number {
  color: #080;
}
.cm-s-ipython span.cm-def {
  color: #00f;
}
.cm-s-ipython span.cm-variable {
  color: #000;
}
.cm-s-ipython span.cm-operator {
  color: #AA22FF;
  font-weight: bold;
}
.cm-s-ipython span.cm-variable-2 {
  color: #1a1a1a;
}
.cm-s-ipython span.cm-variable-3 {
  color: #333333;
}
.cm-s-ipython span.cm-comment {
  color: #408080;
  font-style: italic;
}
.cm-s-ipython span.cm-string {
  color: #BA2121;
}
.cm-s-ipython span.cm-string-2 {
  color: #f50;
}
.cm-s-ipython span.cm-meta {
  color: #AA22FF;
}
.cm-s-ipython span.cm-qualifier {
  color: #555;
}
.cm-s-ipython span.cm-builtin {
  color: #008000;
}
.cm-s-ipython span.cm-bracket {
  color: #997;
}
.cm-s-ipython span.cm-tag {
  color: #170;
}
.cm-s-ipython span.cm-attribute {
  color: #00c;
}
.cm-s-ipython span.cm-header {
  color: blue;
}
.cm-s-ipython span.cm-quote {
  color: #090;
}
.cm-s-ipython span.cm-link {
  color: #00c;
}
.cm-s-ipython span.cm-error {
  color: #f00;
}
.cm-s-ipython span.cm-tab {
  background: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAADAAAAAMCAYAAAAkuj5RAAAAAXNSR0IArs4c6QAAAGFJREFUSMft1LsRQFAQheHPowAKoACx3IgEKtaEHujDjORSgWTH/ZOdnZOcM/sgk/kFFWY0qV8foQwS4MKBCS3qR6ixBJvElOobYAtivseIE120FaowJPN75GMu8j/LfMwNjh4HUpwg4LUAAAAASUVORK5CYII=);
  background-position: right;
  background-repeat: no-repeat;
}
div.output_wrapper {
  /* this position must be relative to enable descendents to be absolute within it */
  position: relative;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  z-index: 1;
}
/* class for the output area when it should be height-limited */
div.output_scroll {
  /* ideally, this would be max-height, but FF barfs all over that */
  height: 24em;
  /* FF needs this *and the wrapper* to specify full width, or it will shrinkwrap */
  width: 100%;
  overflow: auto;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 2px 8px rgba(0, 0, 0, 0.8);
  box-shadow: inset 0 2px 8px rgba(0, 0, 0, 0.8);
  display: block;
}
/* output div while it is collapsed */
div.output_collapsed {
  margin: 0px;
  padding: 0px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
div.out_prompt_overlay {
  height: 100%;
  padding: 0px 0.4em;
  position: absolute;
  border-radius: 2px;
}
div.out_prompt_overlay:hover {
  /* use inner shadow to get border that is computed the same on WebKit/FF */
  -webkit-box-shadow: inset 0 0 1px #000;
  box-shadow: inset 0 0 1px #000;
  background: rgba(240, 240, 240, 0.5);
}
div.output_prompt {
  color: #D84315;
}
/* This class is the outer container of all output sections. */
div.output_area {
  padding: 0px;
  page-break-inside: avoid;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
div.output_area .MathJax_Display {
  text-align: left !important;
}
div.output_area .rendered_html table {
  margin-left: 0;
  margin-right: 0;
}
div.output_area .rendered_html img {
  margin-left: 0;
  margin-right: 0;
}
div.output_area img,
div.output_area svg {
  max-width: 100%;
  height: auto;
}
div.output_area img.unconfined,
div.output_area svg.unconfined {
  max-width: none;
}
/* This is needed to protect the pre formating from global settings such
   as that of bootstrap */
.output {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.output_area {
    /* Old browsers */
    display: -webkit-box;
    -webkit-box-orient: vertical;
    -webkit-box-align: stretch;
    display: -moz-box;
    -moz-box-orient: vertical;
    -moz-box-align: stretch;
    display: box;
    box-orient: vertical;
    box-align: stretch;
    /* Modern browsers */
    display: flex;
    flex-direction: column;
    align-items: stretch;
  }
}
div.output_area pre {
  margin: 0;
  padding: 0;
  border: 0;
  vertical-align: baseline;
  color: black;
  background-color: transparent;
  border-radius: 0;
}
/* This class is for the output subarea inside the output_area and after
   the prompt div. */
div.output_subarea {
  overflow-x: auto;
  padding: 0.4em;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
  max-width: calc(100% - 14ex);
}
div.output_scroll div.output_subarea {
  overflow-x: visible;
}
/* The rest of the output_* classes are for special styling of the different
   output types */
/* all text output has this class: */
div.output_text {
  text-align: left;
  color: #000;
  /* This has to match that of the the CodeMirror class line-height below */
  line-height: 1.21429em;
}
/* stdout/stderr are 'text' as well as 'stream', but execute_result/error are *not* streams */
div.output_stderr {
  background: #fdd;
  /* very light red background for stderr */
}
div.output_latex {
  text-align: left;
}
/* Empty output_javascript divs should have no height */
div.output_javascript:empty {
  padding: 0;
}
.js-error {
  color: darkred;
}
/* raw_input styles */
div.raw_input_container {
  line-height: 1.21429em;
  padding-top: 5px;
}
pre.raw_input_prompt {
  /* nothing needed here. */
}
input.raw_input {
  font-family: monospace;
  font-size: inherit;
  color: inherit;
  width: auto;
  /* make sure input baseline aligns with prompt */
  vertical-align: baseline;
  /* padding + margin = 0.5em between prompt and cursor */
  padding: 0em 0.25em;
  margin: 0em 0.25em;
}
input.raw_input:focus {
  box-shadow: none;
}
p.p-space {
  margin-bottom: 10px;
}
div.output_unrecognized {
  padding: 5px;
  font-weight: bold;
  color: red;
}
div.output_unrecognized a {
  color: inherit;
  text-decoration: none;
}
div.output_unrecognized a:hover {
  color: inherit;
  text-decoration: none;
}
.rendered_html {
  color: #000;
  /* any extras will just be numbers: */
}
.rendered_html em {
  font-style: italic;
}
.rendered_html strong {
  font-weight: bold;
}
.rendered_html u {
  text-decoration: underline;
}
.rendered_html :link {
  text-decoration: underline;
}
.rendered_html :visited {
  text-decoration: underline;
}
.rendered_html h1 {
  font-size: 185.7%;
  margin: 1.08em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h2 {
  font-size: 157.1%;
  margin: 1.27em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h3 {
  font-size: 128.6%;
  margin: 1.55em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h4 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h5 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
  font-style: italic;
}
.rendered_html h6 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
  font-style: italic;
}
.rendered_html h1:first-child {
  margin-top: 0.538em;
}
.rendered_html h2:first-child {
  margin-top: 0.636em;
}
.rendered_html h3:first-child {
  margin-top: 0.777em;
}
.rendered_html h4:first-child {
  margin-top: 1em;
}
.rendered_html h5:first-child {
  margin-top: 1em;
}
.rendered_html h6:first-child {
  margin-top: 1em;
}
.rendered_html ul {
  list-style: disc;
  margin: 0em 2em;
  padding-left: 0px;
}
.rendered_html ul ul {
  list-style: square;
  margin: 0em 2em;
}
.rendered_html ul ul ul {
  list-style: circle;
  margin: 0em 2em;
}
.rendered_html ol {
  list-style: decimal;
  margin: 0em 2em;
  padding-left: 0px;
}
.rendered_html ol ol {
  list-style: upper-alpha;
  margin: 0em 2em;
}
.rendered_html ol ol ol {
  list-style: lower-alpha;
  margin: 0em 2em;
}
.rendered_html ol ol ol ol {
  list-style: lower-roman;
  margin: 0em 2em;
}
.rendered_html ol ol ol ol ol {
  list-style: decimal;
  margin: 0em 2em;
}
.rendered_html * + ul {
  margin-top: 1em;
}
.rendered_html * + ol {
  margin-top: 1em;
}
.rendered_html hr {
  color: black;
  background-color: black;
}
.rendered_html pre {
  margin: 1em 2em;
}
.rendered_html pre,
.rendered_html code {
  border: 0;
  background-color: #fff;
  color: #000;
  font-size: 100%;
  padding: 0px;
}
.rendered_html blockquote {
  margin: 1em 2em;
}
.rendered_html table {
  margin-left: auto;
  margin-right: auto;
  border: 1px solid black;
  border-collapse: collapse;
}
.rendered_html tr,
.rendered_html th,
.rendered_html td {
  border: 1px solid black;
  border-collapse: collapse;
  margin: 1em 2em;
}
.rendered_html td,
.rendered_html th {
  text-align: left;
  vertical-align: middle;
  padding: 4px;
}
.rendered_html th {
  font-weight: bold;
}
.rendered_html * + table {
  margin-top: 1em;
}
.rendered_html p {
  text-align: left;
}
.rendered_html * + p {
  margin-top: 1em;
}
.rendered_html img {
  display: block;
  margin-left: auto;
  margin-right: auto;
}
.rendered_html * + img {
  margin-top: 1em;
}
.rendered_html img,
.rendered_html svg {
  max-width: 100%;
  height: auto;
}
.rendered_html img.unconfined,
.rendered_html svg.unconfined {
  max-width: none;
}
div.text_cell {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.text_cell > div.prompt {
    display: none;
  }
}
div.text_cell_render {
  /*font-family: "Helvetica Neue", Arial, Helvetica, Geneva, sans-serif;*/
  outline: none;
  resize: none;
  width: inherit;
  border-style: none;
  padding: 0.5em 0.5em 0.5em 0.4em;
  color: #000;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
a.anchor-link:link {
  text-decoration: none;
  padding: 0px 20px;
  visibility: hidden;
}
h1:hover .anchor-link,
h2:hover .anchor-link,
h3:hover .anchor-link,
h4:hover .anchor-link,
h5:hover .anchor-link,
h6:hover .anchor-link {
  visibility: visible;
}
.text_cell.rendered .input_area {
  display: none;
}
.text_cell.rendered .rendered_html {
  overflow-x: auto;
  overflow-y: hidden;
}
.text_cell.unrendered .text_cell_render {
  display: none;
}
.cm-header-1,
.cm-header-2,
.cm-header-3,
.cm-header-4,
.cm-header-5,
.cm-header-6 {
  font-weight: bold;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
}
.cm-header-1 {
  font-size: 185.7%;
}
.cm-header-2 {
  font-size: 157.1%;
}
.cm-header-3 {
  font-size: 128.6%;
}
.cm-header-4 {
  font-size: 110%;
}
.cm-header-5 {
  font-size: 100%;
  font-style: italic;
}
.cm-header-6 {
  font-size: 100%;
  font-style: italic;
}
/*!
*
* IPython notebook webapp
*
*/
@media (max-width: 767px) {
  .notebook_app {
    padding-left: 0px;
    padding-right: 0px;
  }
}
#ipython-main-app {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  height: 100%;
}
div#notebook_panel {
  margin: 0px;
  padding: 0px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  height: 100%;
}
div#notebook {
  font-size: 14px;
  line-height: 20px;
  overflow-y: hidden;
  overflow-x: auto;
  width: 100%;
  /* This spaces the page away from the edge of the notebook area */
  padding-top: 20px;
  margin: 0px;
  outline: none;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  min-height: 100%;
}
@media not print {
  #notebook-container {
    padding: 15px;
    background-color: #fff;
    min-height: 0;
    -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
    box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  }
}
@media print {
  #notebook-container {
    width: 100%;
  }
}
div.ui-widget-content {
  border: 1px solid #ababab;
  outline: none;
}
pre.dialog {
  background-color: #f7f7f7;
  border: 1px solid #ddd;
  border-radius: 2px;
  padding: 0.4em;
  padding-left: 2em;
}
p.dialog {
  padding: 0.2em;
}
/* Word-wrap output correctly.  This is the CSS3 spelling, though Firefox seems
   to not honor it correctly.  Webkit browsers (Chrome, rekonq, Safari) do.
 */
pre,
code,
kbd,
samp {
  white-space: pre-wrap;
}
#fonttest {
  font-family: monospace;
}
p {
  margin-bottom: 0;
}
.end_space {
  min-height: 100px;
  transition: height .2s ease;
}
.notebook_app > #header {
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
}
@media not print {
  .notebook_app {
    background-color: #EEE;
  }
}
kbd {
  border-style: solid;
  border-width: 1px;
  box-shadow: none;
  margin: 2px;
  padding-left: 2px;
  padding-right: 2px;
  padding-top: 1px;
  padding-bottom: 1px;
}
/* CSS for the cell toolbar */
.celltoolbar {
  border: thin solid #CFCFCF;
  border-bottom: none;
  background: #EEE;
  border-radius: 2px 2px 0px 0px;
  width: 100%;
  height: 29px;
  padding-right: 4px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
  /* Old browsers */
  -webkit-box-pack: end;
  -moz-box-pack: end;
  box-pack: end;
  /* Modern browsers */
  justify-content: flex-end;
  display: -webkit-flex;
}
@media print {
  .celltoolbar {
    display: none;
  }
}
.ctb_hideshow {
  display: none;
  vertical-align: bottom;
}
/* ctb_show is added to the ctb_hideshow div to show the cell toolbar.
   Cell toolbars are only shown when the ctb_global_show class is also set.
*/
.ctb_global_show .ctb_show.ctb_hideshow {
  display: block;
}
.ctb_global_show .ctb_show + .input_area,
.ctb_global_show .ctb_show + div.text_cell_input,
.ctb_global_show .ctb_show ~ div.text_cell_render {
  border-top-right-radius: 0px;
  border-top-left-radius: 0px;
}
.ctb_global_show .ctb_show ~ div.text_cell_render {
  border: 1px solid #cfcfcf;
}
.celltoolbar {
  font-size: 87%;
  padding-top: 3px;
}
.celltoolbar select {
  display: block;
  width: 100%;
  height: 32px;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
  background-color: #fff;
  background-image: none;
  border: 1px solid #ccc;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  -webkit-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  -o-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
  width: inherit;
  font-size: inherit;
  height: 22px;
  padding: 0px;
  display: inline-block;
}
.celltoolbar select:focus {
  border-color: #66afe9;
  outline: 0;
  -webkit-box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
  box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
}
.celltoolbar select::-moz-placeholder {
  color: #999;
  opacity: 1;
}
.celltoolbar select:-ms-input-placeholder {
  color: #999;
}
.celltoolbar select::-webkit-input-placeholder {
  color: #999;
}
.celltoolbar select::-ms-expand {
  border: 0;
  background-color: transparent;
}
.celltoolbar select[disabled],
.celltoolbar select[readonly],
fieldset[disabled] .celltoolbar select {
  background-color: #eeeeee;
  opacity: 1;
}
.celltoolbar select[disabled],
fieldset[disabled] .celltoolbar select {
  cursor: not-allowed;
}
textarea.celltoolbar select {
  height: auto;
}
select.celltoolbar select {
  height: 30px;
  line-height: 30px;
}
textarea.celltoolbar select,
select[multiple].celltoolbar select {
  height: auto;
}
.celltoolbar label {
  margin-left: 5px;
  margin-right: 5px;
}
.completions {
  position: absolute;
  z-index: 110;
  overflow: hidden;
  border: 1px solid #ababab;
  border-radius: 2px;
  -webkit-box-shadow: 0px 6px 10px -1px #adadad;
  box-shadow: 0px 6px 10px -1px #adadad;
  line-height: 1;
}
.completions select {
  background: white;
  outline: none;
  border: none;
  padding: 0px;
  margin: 0px;
  overflow: auto;
  font-family: monospace;
  font-size: 110%;
  color: #000;
  width: auto;
}
.completions select option.context {
  color: #286090;
}
#kernel_logo_widget {
  float: right !important;
  float: right;
}
#kernel_logo_widget .current_kernel_logo {
  display: none;
  margin-top: -1px;
  margin-bottom: -1px;
  width: 32px;
  height: 32px;
}
#menubar {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  margin-top: 1px;
}
#menubar .navbar {
  border-top: 1px;
  border-radius: 0px 0px 2px 2px;
  margin-bottom: 0px;
}
#menubar .navbar-toggle {
  float: left;
  padding-top: 7px;
  padding-bottom: 7px;
  border: none;
}
#menubar .navbar-collapse {
  clear: left;
}
.nav-wrapper {
  border-bottom: 1px solid #e7e7e7;
}
i.menu-icon {
  padding-top: 4px;
}
ul#help_menu li a {
  overflow: hidden;
  padding-right: 2.2em;
}
ul#help_menu li a i {
  margin-right: -1.2em;
}
.dropdown-submenu {
  position: relative;
}
.dropdown-submenu > .dropdown-menu {
  top: 0;
  left: 100%;
  margin-top: -6px;
  margin-left: -1px;
}
.dropdown-submenu:hover > .dropdown-menu {
  display: block;
}
.dropdown-submenu > a:after {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  display: block;
  content: "\f0da";
  float: right;
  color: #333333;
  margin-top: 2px;
  margin-right: -10px;
}
.dropdown-submenu > a:after.pull-left {
  margin-right: .3em;
}
.dropdown-submenu > a:after.pull-right {
  margin-left: .3em;
}
.dropdown-submenu:hover > a:after {
  color: #262626;
}
.dropdown-submenu.pull-left {
  float: none;
}
.dropdown-submenu.pull-left > .dropdown-menu {
  left: -100%;
  margin-left: 10px;
}
#notification_area {
  float: right !important;
  float: right;
  z-index: 10;
}
.indicator_area {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
}
#kernel_indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
  border-left: 1px solid;
}
#kernel_indicator .kernel_indicator_name {
  padding-left: 5px;
  padding-right: 5px;
}
#modal_indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
}
#readonly-indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
  margin-top: 2px;
  margin-bottom: 0px;
  margin-left: 0px;
  margin-right: 0px;
  display: none;
}
.modal_indicator:before {
  width: 1.28571429em;
  text-align: center;
}
.edit_mode .modal_indicator:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f040";
}
.edit_mode .modal_indicator:before.pull-left {
  margin-right: .3em;
}
.edit_mode .modal_indicator:before.pull-right {
  margin-left: .3em;
}
.command_mode .modal_indicator:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: ' ';
}
.command_mode .modal_indicator:before.pull-left {
  margin-right: .3em;
}
.command_mode .modal_indicator:before.pull-right {
  margin-left: .3em;
}
.kernel_idle_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f10c";
}
.kernel_idle_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_idle_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_busy_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f111";
}
.kernel_busy_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_busy_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_dead_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f1e2";
}
.kernel_dead_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_dead_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_disconnected_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f127";
}
.kernel_disconnected_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_disconnected_icon:before.pull-right {
  margin-left: .3em;
}
.notification_widget {
  color: #777;
  z-index: 10;
  background: rgba(240, 240, 240, 0.5);
  margin-right: 4px;
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
.notification_widget:focus,
.notification_widget.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
.notification_widget:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.notification_widget:active,
.notification_widget.active,
.open > .dropdown-toggle.notification_widget {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.notification_widget:active:hover,
.notification_widget.active:hover,
.open > .dropdown-toggle.notification_widget:hover,
.notification_widget:active:focus,
.notification_widget.active:focus,
.open > .dropdown-toggle.notification_widget:focus,
.notification_widget:active.focus,
.notification_widget.active.focus,
.open > .dropdown-toggle.notification_widget.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
.notification_widget:active,
.notification_widget.active,
.open > .dropdown-toggle.notification_widget {
  background-image: none;
}
.notification_widget.disabled:hover,
.notification_widget[disabled]:hover,
fieldset[disabled] .notification_widget:hover,
.notification_widget.disabled:focus,
.notification_widget[disabled]:focus,
fieldset[disabled] .notification_widget:focus,
.notification_widget.disabled.focus,
.notification_widget[disabled].focus,
fieldset[disabled] .notification_widget.focus {
  background-color: #fff;
  border-color: #ccc;
}
.notification_widget .badge {
  color: #fff;
  background-color: #333;
}
.notification_widget.warning {
  color: #fff;
  background-color: #f0ad4e;
  border-color: #eea236;
}
.notification_widget.warning:focus,
.notification_widget.warning.focus {
  color: #fff;
  background-color: #ec971f;
  border-color: #985f0d;
}
.notification_widget.warning:hover {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.notification_widget.warning:active,
.notification_widget.warning.active,
.open > .dropdown-toggle.notification_widget.warning {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.notification_widget.warning:active:hover,
.notification_widget.warning.active:hover,
.open > .dropdown-toggle.notification_widget.warning:hover,
.notification_widget.warning:active:focus,
.notification_widget.warning.active:focus,
.open > .dropdown-toggle.notification_widget.warning:focus,
.notification_widget.warning:active.focus,
.notification_widget.warning.active.focus,
.open > .dropdown-toggle.notification_widget.warning.focus {
  color: #fff;
  background-color: #d58512;
  border-color: #985f0d;
}
.notification_widget.warning:active,
.notification_widget.warning.active,
.open > .dropdown-toggle.notification_widget.warning {
  background-image: none;
}
.notification_widget.warning.disabled:hover,
.notification_widget.warning[disabled]:hover,
fieldset[disabled] .notification_widget.warning:hover,
.notification_widget.warning.disabled:focus,
.notification_widget.warning[disabled]:focus,
fieldset[disabled] .notification_widget.warning:focus,
.notification_widget.warning.disabled.focus,
.notification_widget.warning[disabled].focus,
fieldset[disabled] .notification_widget.warning.focus {
  background-color: #f0ad4e;
  border-color: #eea236;
}
.notification_widget.warning .badge {
  color: #f0ad4e;
  background-color: #fff;
}
.notification_widget.success {
  color: #fff;
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.notification_widget.success:focus,
.notification_widget.success.focus {
  color: #fff;
  background-color: #449d44;
  border-color: #255625;
}
.notification_widget.success:hover {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.notification_widget.success:active,
.notification_widget.success.active,
.open > .dropdown-toggle.notification_widget.success {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.notification_widget.success:active:hover,
.notification_widget.success.active:hover,
.open > .dropdown-toggle.notification_widget.success:hover,
.notification_widget.success:active:focus,
.notification_widget.success.active:focus,
.open > .dropdown-toggle.notification_widget.success:focus,
.notification_widget.success:active.focus,
.notification_widget.success.active.focus,
.open > .dropdown-toggle.notification_widget.success.focus {
  color: #fff;
  background-color: #398439;
  border-color: #255625;
}
.notification_widget.success:active,
.notification_widget.success.active,
.open > .dropdown-toggle.notification_widget.success {
  background-image: none;
}
.notification_widget.success.disabled:hover,
.notification_widget.success[disabled]:hover,
fieldset[disabled] .notification_widget.success:hover,
.notification_widget.success.disabled:focus,
.notification_widget.success[disabled]:focus,
fieldset[disabled] .notification_widget.success:focus,
.notification_widget.success.disabled.focus,
.notification_widget.success[disabled].focus,
fieldset[disabled] .notification_widget.success.focus {
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.notification_widget.success .badge {
  color: #5cb85c;
  background-color: #fff;
}
.notification_widget.info {
  color: #fff;
  background-color: #5bc0de;
  border-color: #46b8da;
}
.notification_widget.info:focus,
.notification_widget.info.focus {
  color: #fff;
  background-color: #31b0d5;
  border-color: #1b6d85;
}
.notification_widget.info:hover {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.notification_widget.info:active,
.notification_widget.info.active,
.open > .dropdown-toggle.notification_widget.info {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.notification_widget.info:active:hover,
.notification_widget.info.active:hover,
.open > .dropdown-toggle.notification_widget.info:hover,
.notification_widget.info:active:focus,
.notification_widget.info.active:focus,
.open > .dropdown-toggle.notification_widget.info:focus,
.notification_widget.info:active.focus,
.notification_widget.info.active.focus,
.open > .dropdown-toggle.notification_widget.info.focus {
  color: #fff;
  background-color: #269abc;
  border-color: #1b6d85;
}
.notification_widget.info:active,
.notification_widget.info.active,
.open > .dropdown-toggle.notification_widget.info {
  background-image: none;
}
.notification_widget.info.disabled:hover,
.notification_widget.info[disabled]:hover,
fieldset[disabled] .notification_widget.info:hover,
.notification_widget.info.disabled:focus,
.notification_widget.info[disabled]:focus,
fieldset[disabled] .notification_widget.info:focus,
.notification_widget.info.disabled.focus,
.notification_widget.info[disabled].focus,
fieldset[disabled] .notification_widget.info.focus {
  background-color: #5bc0de;
  border-color: #46b8da;
}
.notification_widget.info .badge {
  color: #5bc0de;
  background-color: #fff;
}
.notification_widget.danger {
  color: #fff;
  background-color: #d9534f;
  border-color: #d43f3a;
}
.notification_widget.danger:focus,
.notification_widget.danger.focus {
  color: #fff;
  background-color: #c9302c;
  border-color: #761c19;
}
.notification_widget.danger:hover {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.notification_widget.danger:active,
.notification_widget.danger.active,
.open > .dropdown-toggle.notification_widget.danger {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.notification_widget.danger:active:hover,
.notification_widget.danger.active:hover,
.open > .dropdown-toggle.notification_widget.danger:hover,
.notification_widget.danger:active:focus,
.notification_widget.danger.active:focus,
.open > .dropdown-toggle.notification_widget.danger:focus,
.notification_widget.danger:active.focus,
.notification_widget.danger.active.focus,
.open > .dropdown-toggle.notification_widget.danger.focus {
  color: #fff;
  background-color: #ac2925;
  border-color: #761c19;
}
.notification_widget.danger:active,
.notification_widget.danger.active,
.open > .dropdown-toggle.notification_widget.danger {
  background-image: none;
}
.notification_widget.danger.disabled:hover,
.notification_widget.danger[disabled]:hover,
fieldset[disabled] .notification_widget.danger:hover,
.notification_widget.danger.disabled:focus,
.notification_widget.danger[disabled]:focus,
fieldset[disabled] .notification_widget.danger:focus,
.notification_widget.danger.disabled.focus,
.notification_widget.danger[disabled].focus,
fieldset[disabled] .notification_widget.danger.focus {
  background-color: #d9534f;
  border-color: #d43f3a;
}
.notification_widget.danger .badge {
  color: #d9534f;
  background-color: #fff;
}
div#pager {
  background-color: #fff;
  font-size: 14px;
  line-height: 20px;
  overflow: hidden;
  display: none;
  position: fixed;
  bottom: 0px;
  width: 100%;
  max-height: 50%;
  padding-top: 8px;
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  /* Display over codemirror */
  z-index: 100;
  /* Hack which prevents jquery ui resizable from changing top. */
  top: auto !important;
}
div#pager pre {
  line-height: 1.21429em;
  color: #000;
  background-color: #f7f7f7;
  padding: 0.4em;
}
div#pager #pager-button-area {
  position: absolute;
  top: 8px;
  right: 20px;
}
div#pager #pager-contents {
  position: relative;
  overflow: auto;
  width: 100%;
  height: 100%;
}
div#pager #pager-contents #pager-container {
  position: relative;
  padding: 15px 0px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
div#pager .ui-resizable-handle {
  top: 0px;
  height: 8px;
  background: #f7f7f7;
  border-top: 1px solid #cfcfcf;
  border-bottom: 1px solid #cfcfcf;
  /* This injects handle bars (a short, wide = symbol) for 
        the resize handle. */
}
div#pager .ui-resizable-handle::after {
  content: '';
  top: 2px;
  left: 50%;
  height: 3px;
  width: 30px;
  margin-left: -15px;
  position: absolute;
  border-top: 1px solid #cfcfcf;
}
.quickhelp {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
  line-height: 1.8em;
}
.shortcut_key {
  display: inline-block;
  width: 21ex;
  text-align: right;
  font-family: monospace;
}
.shortcut_descr {
  display: inline-block;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
span.save_widget {
  margin-top: 6px;
}
span.save_widget span.filename {
  height: 1em;
  line-height: 1em;
  padding: 3px;
  margin-left: 16px;
  border: none;
  font-size: 146.5%;
  border-radius: 2px;
}
span.save_widget span.filename:hover {
  background-color: #e6e6e6;
}
span.checkpoint_status,
span.autosave_status {
  font-size: small;
}
@media (max-width: 767px) {
  span.save_widget {
    font-size: small;
  }
  span.checkpoint_status,
  span.autosave_status {
    display: none;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  span.checkpoint_status {
    display: none;
  }
  span.autosave_status {
    font-size: x-small;
  }
}
.toolbar {
  padding: 0px;
  margin-left: -5px;
  margin-top: 2px;
  margin-bottom: 5px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
.toolbar select,
.toolbar label {
  width: auto;
  vertical-align: middle;
  margin-right: 2px;
  margin-bottom: 0px;
  display: inline;
  font-size: 92%;
  margin-left: 0.3em;
  margin-right: 0.3em;
  padding: 0px;
  padding-top: 3px;
}
.toolbar .btn {
  padding: 2px 8px;
}
.toolbar .btn-group {
  margin-top: 0px;
  margin-left: 5px;
}
#maintoolbar {
  margin-bottom: -3px;
  margin-top: -8px;
  border: 0px;
  min-height: 27px;
  margin-left: 0px;
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<h1 id="Association-Analysis-of-Sequence-Data-using-Variant-Association-Tools-(VAT)-for-Complex-Traits">Association Analysis of Sequence Data using Variant Association Tools (VAT) for Complex Traits<a class="anchor-link" href="#Association-Analysis-of-Sequence-Data-using-Variant-Association-Tools-(VAT)-for-Complex-Traits"></a></h1>
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<p>Copyright (c) 2018, Gao Wang, Biao Li, Diana Cornejo Sánchez &amp; Suzanne M. Leal</p>

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<h2 id="PURPOSE">PURPOSE<a class="anchor-link" href="#PURPOSE"></a></h2><p>Variant Association Tools [VAT, Wang et al (2014)] [1] was developed to perform quality control and association analysis of sequence data. It can also be used to analyze genotype data, e.g. exome chip data and imputed data. The software incorporates many rare variant association methods which include but not limited to Combined Multivariate Collapsing (CMC) [2], Burden of Rare Variants (BRV) [3], Weighted Sum Statistic (WSS) [4], Kernel Based Adaptive Cluster (KBAC) [5], Variable Threshold (VT) [6] and Sequence Kernel Association Test (SKAT) [7].
VAT inherits the intuitive command-line interface of Variant Tools (VTools) [8] with re-design and implementation of its infrastructure to accommodate the scale of dataset generated from current sequencing efforts on large populations. Features of VAT are implemented into VTools subcommand system.</p>

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<h2 id="RESOURCES">RESOURCES<a class="anchor-link" href="#RESOURCES"></a></h2><p>To reproduce this tutorial:</p>
<p><a href="https://github.com/gaow/ismb-2018">https://github.com/gaow/ismb-2018</a></p>
<p>Basic concepts to handle sequence data using <code>vtools</code> can be found at:</p>
<p><a href="http://varianttools.sourceforge.net/Main/Concepts">http://varianttools.sourceforge.net/Main/Concepts</a></p>
<p>VAT Software documentation:</p>
<p><a href="http://varianttools.sourceforge.net/Main/Documentation">http://varianttools.sourceforge.net/Main/Documentation</a></p>

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<h3 id="Genotype-data">Genotype data<a class="anchor-link" href="#Genotype-data"></a></h3><p>Exome genotype data was downloaded from the 1000 Genomes pilot data July 2010 release for both the CEU and YRI populations. Only the autosomes are contained in the datasets accompanying this exercise.
The data sets (<code>CEU.exon.2010_03.genotypes.vcf.gz, YRI.exon.2010_03.genotypes.vcf.gz</code>) are available from:
ftp://ftp.1000genomes.ebi.ac.uk/vol1/ftp/pilot_data/release/2010_07/exon/snps</p>

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<h3 id="Phenotype-data">Phenotype data<a class="anchor-link" href="#Phenotype-data"></a></h3><p>To demonstrate the association analysis, we simulated a quantitative trait phenotype (BMI). Please note that these phenotypes are NOT from the 1000 genome project.</p>

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<h3 id="Computation-resources">Computation resources<a class="anchor-link" href="#Computation-resources"></a></h3><p>Due to the nature of next-generation sequencing data, a reasonably powerful machine with high speed internet connection is needed to use this tool for real-world applications. For this reason, in this tutorial we will use a small demo dataset to demonstrate association analysis.</p>

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<h1 id="Part-I:-Data-Quality-Control,-Annotation-and-Variant/sample-Selection">Part I: Data Quality Control, Annotation and Variant/sample Selection<a class="anchor-link" href="#Part-I:-Data-Quality-Control,-Annotation-and-Variant/sample-Selection"></a></h1><h2 id="1.1--Getting-started">1.1  Getting started<a class="anchor-link" href="#1.1--Getting-started"></a></h2><p>Please navigate to the exercise data directory,</p>

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<pre>/data/ismb-2018/data</pre>
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<p>and check the available subcommands by typing:</p>

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<pre>usage: vtools [-h] [--version]
              {init,import,phenotype,show,liftover,use,update,select,exclude,compare,output,export,remove,associate,simulate,admin,execute}
              ...

A variant calling, processing, annotation and analysis tool for next-
generation sequencing studies.

optional arguments:
  -h, --help            show this help message and exit
  --version             show program&#39;s version number and exit

subcommands:
  {init,import,phenotype,show,liftover,use,update,select,exclude,compare,output,export,remove,associate,simulate,admin,execute}
    init                Create a new project, or a subproject from an existing
                        parent project, or merge several existing projects
                        into one
    import              Import variants and related sample genotype from files
                        in specified formats
    phenotype           Manage sample phenotypes
    show                Display content of a project
    liftover            Set alternative reference genome and update
                        alternative coordinates of all variant tables
    use                 Prepare (download or import if necessary) and use an
                        annotation database
    update              Add or update fields of existing variants and genotype
                        using information from specified existing fields,
                        sample genotype, or external files
    select              Output or save select variants that match specified
                        conditions
    exclude             Output or save variants after excluding variants that
                        match specified conditions
    compare             Compare sites, variants, or genotypes of variants in
                        two or more variant tables
    output              Output variants in tab or comma separated format
    export              Export samples (variants and genotypes) in specified
                        format
    remove              Remove project or its contents such as variant tables,
                        fields, and annotation databases.
    associate           Test association between variants and phenotypes
    simulate            Simulate sequencing data using specified simulation
                        models.
    admin               Perform various administrative tasks including merge
                        and rename samples.
    execute             Execute a pipeline or a SQL query

Use &#39;vtools cmd -h&#39; for details about each command. Please contact Bo Peng
(bpeng at mdanderson.org) if you have any question.
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<p>Subcommand system is used for various data manipulation tasks (to check details of each subcommand use <code>vtools &lt;name of subcommand&gt; -h</code>). This tutorial is mission oriented and focuses on a subset of the commands that are relevant to variant-phenotype association analysis, rather than introducing them systematically. For additional functionality, please refer to documentation and tutorials online.</p>

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<h3 id="Initialize-a-project">Initialize a project<a class="anchor-link" href="#Initialize-a-project"></a></h3>
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<pre>INFO: variant tools 2.7.0 : Copyright (c) 2011 - 2016 Bo Peng
INFO: Please visit http://varianttools.sourceforge.net for more information.
INFO: Creating a new project VATDemo
<span class="ansi-magenta-intense-fg">WARNING</span>: <span class="ansi-magenta-intense-fg">Resource file annoDB/dbNSFP-hg18_hg19_2_9.DB.gz has been updated. Please update it using command &#34;vtools admin --update_resource existing&#34;.</span>
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<p>Command <code>vtools init</code> creates a new project in the current directory. A directory can only have one project. After a project is created, subsequent <code>vtools</code> calls will automatically load the project in the current directory. Working from outside of a project directory is not allowed.</p>

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<h3 id="Import-variant-and-genotype-data">Import variant and genotype data<a class="anchor-link" href="#Import-variant-and-genotype-data"></a></h3>
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<p>Import all vcf files under the current directory:</p>

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<pre>INFO: Importing variants and genotypes from CEU.exon.2010_03.genotypes.vcf.gz (1/2)
CEU.exon.2010_03.genotypes.vcf.gz: 100% [=============] 4,306 1.9K/s in 00:00:02
INFO: 3,489 variants (3,489 new, 3,489 SNVs) from 3,500 lines are imported, with a total of 288,291 genotypes from 90 samples.
INFO: Importing variants and genotypes from YRI.exon.2010_03.genotypes.vcf.gz (2/2)
YRI.exon.2010_03.genotypes.vcf.gz: 100% [=============] 5,967 1.4K/s in 00:00:04
INFO: 5,175 variants (3,498 new, 5,175 SNVs) from 5,186 lines are imported, with a total of 513,911 genotypes from 112 samples.
INFO: 8,664 variants (6,987 new, 8,664 SNVs) from 8,686 lines are imported, with a total of 802,202 genotypes from 202 samples.
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<p>Command <code>vtools import</code> imports variants, sample genotypes and related information fields. The imported variants are saved to the master variant table for the project, along with their information fields.</p>
<p>The command above imports two vcf files sequentially into an empty <code>vtools</code> project. The second <code>INFO</code> message in the screen output shows that 3,489 variant sites are imported from the first vcf file, where 3,489 new means that all of them are new because prior to importing the first vcf the project was empty so there was 0 site. The fourth <code>INFO</code> message tells that 5,175 variant sites are imported from the second vcf file, but only 3,498 of them are new (which are not seen in the existing 3,489) because prior to importing the second vcf there were already 3,489 existing variant sites from first vcf.</p>
<p>Thus, 5,175 - 3,498 = 1,677 variant sites are overlapped sites between first and second vcfs. The last <code>INFO</code> message summarizes that the sum of variant sites contained in both vcfs is 8,664 = 3,489 + 5,175, where there are 6,987 variant sites after merging variants from both vcfs.</p>
<p>More details about <code>vtools import</code> command can be found at:</p>
<p><a href="http://varianttools.sourceforge.net/Vtools/Import">http://varianttools.sourceforge.net/Vtools/Import</a></p>
<p>Since the input VCF file uses hg18 as the reference genome while most modern annotation data sources are hg19-based, we need to "liftover" our project using hg19 in order to use various annotation sources in the analysis. Vtools provides a command which is based on the tool of USCS <code>liftOver</code> to map the variants from existing reference genome to an alternative build. More details about <code>vtools liftover</code> command can be found at:</p>
<p><a href="http://varianttools.sourceforge.net/Vtools/Liftover">http://varianttools.sourceforge.net/Vtools/Liftover</a></p>

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<pre>INFO: Downloading liftOver tool from UCSC
--2018-07-06 10:56:54--  http://hgdownload.cse.ucsc.edu/admin/exe/linux.x86_64/liftOver
Resolving hgdownload.cse.ucsc.edu (hgdownload.cse.ucsc.edu)... 128.114.119.163
Connecting to hgdownload.cse.ucsc.edu (hgdownload.cse.ucsc.edu)|128.114.119.163|:80... connected.
HTTP request sent, awaiting response... 200 OK
Length: 16523996 (16M) [text/plain]
Saving to: ‘/data/ismb-2018/data/.vtools_cache/liftOver_tmp23135’

/data/ismb-2018/dat 100%[=====================&gt;]  15.76M  1.81MB/s   in 9.2s   

2018-07-06 10:57:04 (1.72 MB/s) - ‘/data/ismb-2018/data/.vtools_cache/liftOver_tmp23135’ saved [16523996/16523996]

INFO: Downloading liftOver chain file from UCSC
--2018-07-06 10:57:04--  http://hgdownload.cse.ucsc.edu/goldenPath/hg18/liftOver/hg18ToHg19.over.chain.gz
Resolving hgdownload.cse.ucsc.edu (hgdownload.cse.ucsc.edu)... 128.114.119.163
Connecting to hgdownload.cse.ucsc.edu (hgdownload.cse.ucsc.edu)|128.114.119.163|:80... connected.
HTTP request sent, awaiting response... 200 OK
Length: 140346 (137K) [application/x-gzip]
Saving to: ‘/data/ismb-2018/data/.vtools_cache/hg18ToHg19.over.chain_tmp23135.gz’

/data/ismb-2018/dat 100%[=====================&gt;] 137.06K   583KB/s   in 0.2s   

2018-07-06 10:57:04 (583 KB/s) - ‘/data/ismb-2018/data/.vtools_cache/hg18ToHg19.over.chain_tmp23135.gz’ saved [140346/140346]

INFO: Exporting variants in BED format
Exporting variants: 100% [==========================] 6,987 494.4K/s in 00:00:00
INFO: Running UCSC liftOver tool
INFO: Flipping primary and alternative reference genome
Updating table variant: 100% [========================] 6,987 67.0/s in 00:01:44
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<h3 id="Import-phenotype-data">Import phenotype data<a class="anchor-link" href="#Import-phenotype-data"></a></h3><p>The aim of the association test is to find variants that modulate the phenotype BMI. We simulated BMI values for each of the individuals. The phenotype file must be in plain text format with sample names matching the sample IDs in the vcf file(s):</p>

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    <div class='dataframe_container' style="max-height:400px">
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    <table border="1" id="dataframe_1" class="sos_dataframe dataframe">
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      <th> &nbsp; <i class="fa fa-sort" style="color:lightgray" onclick="sortDataFrame('1', 0, 'numeric')"></th>
      <th>sample_name &nbsp; <i class="fa fa-sort" style="color:lightgray" onclick="sortDataFrame('1', 1, 'alphabetic')"></th>
      <th>panel &nbsp; <i class="fa fa-sort" style="color:lightgray" onclick="sortDataFrame('1', 2, 'alphabetic')"></th>
      <th>SEX &nbsp; <i class="fa fa-sort" style="color:lightgray" onclick="sortDataFrame('1', 3, 'numeric')"></th>
      <th>BMI &nbsp; <i class="fa fa-sort" style="color:lightgray" onclick="sortDataFrame('1', 4, 'numeric')"></th>
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    <tr>
      <th>0</th>
      <td>NA06984</td>
      <td>ILLUMINA</td>
      <td>1</td>
      <td>36.353</td>
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    <tr>
      <th>1</th>
      <td>NA06985</td>
      <td>NaN</td>
      <td>2</td>
      <td>21.415</td>
    </tr>
    <tr>
      <th>2</th>
      <td>NA06986</td>
      <td>ABI_SOLID+ILLUMINA</td>
      <td>1</td>
      <td>26.898</td>
    </tr>
    <tr>
      <th>3</th>
      <td>NA06989</td>
      <td>ILLUMINA</td>
      <td>2</td>
      <td>25.015</td>
    </tr>
    <tr>
      <th>4</th>
      <td>NA06994</td>
      <td>ABI_SOLID+ILLUMINA</td>
      <td>1</td>
      <td>23.858</td>
    </tr>
    <tr>
      <th>5</th>
      <td>NA07000</td>
      <td>ABI_SOLID+ILLUMINA</td>
      <td>2</td>
      <td>36.226</td>
    </tr>
    <tr>
      <th>6</th>
      <td>NA07037</td>
      <td>ILLUMINA</td>
      <td>1</td>
      <td>32.513</td>
    </tr>
    <tr>
      <th>7</th>
      <td>NA07048</td>
      <td>ILLUMINA</td>
      <td>2</td>
      <td>17.570</td>
    </tr>
    <tr>
      <th>8</th>
      <td>NA07051</td>
      <td>ILLUMINA</td>
      <td>1</td>
      <td>37.142</td>
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      <th>9</th>
      <td>NA07346</td>
      <td>NaN</td>
      <td>2</td>
      <td>30.978</td>
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<p>The phenotype file includes information for every individual, the sample name, sequencing panel, sex and BMI. To import the phenotype data:</p>

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<pre>INFO: Adding phenotype panel of type VARCHAR(24)
INFO: Adding phenotype SEX of type INT
INFO: Adding phenotype BMI of type FLOAT
INFO: 3 field (3 new, 0 existing) phenotypes of 202 samples are updated.
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<p>Unlike <code>vtools import</code>, this command imports/adds properties to samples rather than to variants. More details about <code>vtools phenotype</code> command can be found at:</p>
<p><a href="http://varianttools.sourceforge.net/Vtools/Phenotype">http://varianttools.sourceforge.net/Vtools/Phenotype</a></p>

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<h3 id="View-imported-data">View imported data<a class="anchor-link" href="#View-imported-data"></a></h3><p>Summary information for the project can be viewed anytime using the command <code>vtools show</code>, which displays various project and system information. More details about <code>vtools show</code> can be found at:</p>
<p><a href="http://varianttools.sourceforge.net/Vtools/Show">http://varianttools.sourceforge.net/Vtools/Show</a></p>
<p>Some useful data summary commands are:</p>

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<pre>Project name:                VATDemo
Created on:                  Fri Jul  6 10:56:25 2018
Primary reference genome:    hg19
Secondary reference genome:  hg18
Runtime options:             verbosity=1, shared_resource=/home/gaow/.variant_tools, local_resource=/home/gaow/.variant_tools
Variant tables:              variant
Annotation databases:        

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<pre>table      #variants     date message
variant        6,987    Jul06 Master variant table
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<pre>Name:                   variant
Description:            Master variant table
Creation date:          Jul06
Command:
Fields:                 variant_id, bin, chr, pos, ref, alt, DP, filter,
                        alt_bin, alt_chr, alt_pos
Number of variants:     6987
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<pre>variant.chr (char)      Chromosome name (VARCHAR)
variant.pos (int)       Position (INT, 1-based)
variant.ref (char)      Reference allele (VARCHAR, - for missing allele of an
                        insertion)
variant.alt (char)      Alternative allele (VARCHAR, - for missing allele of an
                        deletion)
variant.DP (int)
variant.filter (char)
variant.alt_chr (char)
variant.alt_pos (int)
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<h2 id="1.2--Overview-of-variant-and-genotype-data">1.2  Overview of variant and genotype data<a class="anchor-link" href="#1.2--Overview-of-variant-and-genotype-data"></a></h2><h3 id="Total-number-of-variants">Total number of variants<a class="anchor-link" href="#Total-number-of-variants"></a></h3><p>The number of imported variants may be greater than number of lines in the vcf file, because when a variant has two alternative alleles (e.g. A-&gt;T/C) it is treated as two separate variants.</p>

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<pre>Counting variants: 4 788.4/s in 00:00:00
6987
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<p>There are 6987 variants in our toy data-set.</p>

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<p><code>vtools select table condition action</code> selects from a variant table <code>table</code> a subset of variants satisfying a specified <code>condition</code>, and perform an <code>action</code> of</p>
<ul>
<li>creating a new variant table if <code>--to_table</code> is specified.</li>
<li>counting the number of variants if <code>--count</code> is specified.</li>
<li>outputting selected variants if <code>--output</code> is specified.</li>
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<p>The <code>condition</code> should be a SQL expression using one or more fields in a project (displayed in <code>vtools show</code> fields). If the condition argument is unspecified, then all variants in the table will be selected. An optional condition <code>--samples [condition]</code> can also be used to limit selected variants to specific samples. More details about <code>vtools select</code> command can be found at:</p>
<p><a href="http://varianttools.sourceforge.net/Vtools/Select">http://varianttools.sourceforge.net/Vtools/Select</a></p>

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<h3 id="Genotype-Summary">Genotype Summary<a class="anchor-link" href="#Genotype-Summary"></a></h3><p>The command <code>vtools show genotypes</code> displays the number of genotypes for each sample and names of the available genotype information fields for each sample, e.g. GT - genotype; DP geno - genotype read depth. Such information is useful for the calculation of summary statistics of genotypes (e.g. depth of coverage).</p>

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<pre>sample_name	filename                 	num_genotypes	sample_genotype_fields
NA06984    	CEU.exon...notypes.vcf.gz	3162         	GT,DP_geno
NA06985    	CEU.exon...notypes.vcf.gz	3144         	GT,DP_geno
NA06986    	CEU.exon...notypes.vcf.gz	3437         	GT,DP_geno
NA06989    	CEU.exon...notypes.vcf.gz	3130         	GT,DP_geno
NA06994    	CEU.exon...notypes.vcf.gz	3002         	GT,DP_geno
NA07000    	CEU.exon...notypes.vcf.gz	3388         	GT,DP_geno
NA07037    	CEU.exon...notypes.vcf.gz	3374         	GT,DP_geno
NA07048    	CEU.exon...notypes.vcf.gz	3373         	GT,DP_geno
NA07051    	CEU.exon...notypes.vcf.gz	3451         	GT,DP_geno
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<h3 id="Variant-Quality-Overview">Variant Quality Overview<a class="anchor-link" href="#Variant-Quality-Overview"></a></h3><p>The following command calculates summary statistics on the variant site depth of coverage (DP). Below is the command to calculate depth of coverage information for all variant sites.</p>

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<pre>max_DP_	min_DP_	avg_DP_           	stdev_DP_         	lower_quartile_DP_	upper_quartile_DP_
25490  	13     	6815.7702876771145	3434.2804009099777	4301              	9143
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<p>In the test data, the maximum DP for variant sites is 25490, minimum DP 13, average DP about 6815, standard deviation of DP about 3434, lower quartile of DP 4301 and upper quartile of DP 9143.</p>
<p>The same syntax can be applied to other variant information or annotation information fields. The command <code>vtools output &lt;name of variant table&gt;</code> outputs properties of variants in a specified variant table. The properties include fields from annotation databases and variant tables, basically fields outputted from command <code>vtools show fields</code>, and SQL-supported functions and expressions. There are several freely available SQL resources on the web to learn more about SQL functions and expressions.</p>
<p>It is also possible to view variant level summary statistic for variants satisfying certain filtering criteria using <code>vtools select &lt;name of variant table&gt;</code> command, for example to count only variants having passed all quality filters:</p>

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<pre>Counting variants: 5 910.3/s in 00:00:00
6987
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<p>All 6987 variants have passed the quality filters. To combine variant filtering and summary statistics:</p>

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<pre>max_DP_	min_DP_	avg_DP_           	stdev_DP_         	lower_quartile_DP_	upper_quartile_DP_
25490  	13     	6815.7702876771145	3434.2804009099777	4301              	9143
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<p>The output information of command above will be the same as the previous vtools output command, since all variants have passed quality filter.</p>

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<h2 id="1.3--Data-exploration">1.3  Data exploration<a class="anchor-link" href="#1.3--Data-exploration"></a></h2><h3 id="Variant-level-summaries">Variant level summaries<a class="anchor-link" href="#Variant-level-summaries"></a></h3><p>The command below will calculate:</p>
<ul>
<li><code>total</code>: Total number of genotypes (GT) for a variant</li>
<li><code>num</code>: Total number of alternative alleles across all samples</li>
<li><code>het</code>: Total number of heterozygote genotypes 1/0</li>
<li><code>hom</code>: Total number of homozygote genotypes 1/1</li>
<li><code>other</code>: Total number of double-homozygotes 1/2</li>
<li><code>min/max/meanDP</code>: Summaries for depth of coverage and genotype quality across samples</li>
<li><code>maf</code>: Minor allele frequency</li>
<li>Add calculated variant level statistics to <code>fields</code>, which can be shown by commands <code>vtools show fields</code> and <code>vtools show table variant</code></li>
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<pre>Counting variants: 100% [==============================] 202 102.7/s in 00:00:01
INFO: Adding variant info field num with type INT
INFO: Adding variant info field hom with type INT
INFO: Adding variant info field het with type INT
INFO: Adding variant info field other with type INT
INFO: Adding variant info field total with type INT
INFO: Adding variant info field maf with type FLOAT
INFO: Adding variant info field minDP with type INT
INFO: Adding variant info field maxDP with type INT
INFO: Adding variant info field meanDP with type FLOAT
Updating variant: 100% [============================] 6,987 103.9K/s in 00:00:00
INFO: 6987 records are updated
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<pre>variant.chr (char)      Chromosome name (VARCHAR)
variant.pos (int)       Position (INT, 1-based)
variant.ref (char)      Reference allele (VARCHAR, - for missing allele of an
                        insertion)
variant.alt (char)      Alternative allele (VARCHAR, - for missing allele of an
                        deletion)
variant.DP (int)
variant.filter (char)
variant.alt_chr (char)
variant.alt_pos (int)
variant.num (int)       Created from stat &#34;#(alt)&#34;  with type INT on Jul06
variant.hom (int)       Created from stat &#34;#(hom)&#34;  with type INT on Jul06
variant.het (int)       Created from stat &#34;#(het)&#34;  with type INT on Jul06
variant.other (int)     Created from stat &#34;#(other)&#34;  with type INT on Jul06
variant.total (int)     Created from stat &#34;#(GT)&#34;  with type INT on Jul06
variant.maf (float)     Created from stat &#34;maf()&#34;  with type FLOAT on Jul06
variant.minDP (int)     Created from stat &#34;min(DP_geno)&#34;  with type INT on Jul06
variant.maxDP (int)     Created from stat &#34;max(DP_geno)&#34;  with type INT on Jul06
variant.meanDP (float)  Created from stat &#34;avg(DP_geno)&#34;  with type FLOAT on
                        Jul06
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<pre>Name:                   variant
Description:            Master variant table
Creation date:          Jul06
Command:
Fields:                 variant_id, bin, chr, pos, ref, alt, DP, filter,
                        alt_bin, alt_chr, alt_pos, num, hom, het, other, total,
                        maf, minDP, maxDP, meanDP
Number of variants:     6987
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<p>Command <code>vtools update</code> updates variant info fields (and to a lesser extend genotype info fields) by adding more fields or updating values at existing fields. It does not add any new variants or genotypes, and does not change existing variants, samples, or genotypes. Using three parameters <code>--from_file</code>, <code>--from_stat</code>, and <code>--set</code>, variant information fields could be updated from external file, sample genotypes, and existing fields. More details about vtools update command can be found at</p>
<p><a href="http://varianttools.sourceforge.net/Vtools/Update">http://varianttools.sourceforge.net/Vtools/Update</a></p>

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<h3 id="Summaries-for-different-genotype-depth-(GD)-and-genotype-quality-(GQ)-filters">Summaries for different genotype depth (GD) and genotype quality (GQ) filters<a class="anchor-link" href="#Summaries-for-different-genotype-depth-(GD)-and-genotype-quality-(GQ)-filters"></a></h3><p>The <code>--genotypes CONDITION</code> option restricts calculation to genotypes satisfying a given condition. Later we will remove individual genotypes by <code>DP_geno</code> filters. The command below will calculate summary statistics genotypes of all samples per variant site. It can assist us in determining filtering criteria for genotype call quality.</p>

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<pre>Counting variants: 100% [==============================] 202 331.2/s in 00:00:00
INFO: Adding variant info field numGD10 with type INT
INFO: Adding variant info field homGD10 with type INT
INFO: Adding variant info field hetGD10 with type INT
INFO: Adding variant info field otherGD10 with type INT
INFO: Adding variant info field totalGD10 with type INT
INFO: Adding variant info field mafGD10 with type FLOAT
Updating variant: 100% [============================] 6,976 129.2K/s in 00:00:00
INFO: 6976 records are updated
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<pre>variant.chr (char)      Chromosome name (VARCHAR)
variant.pos (int)       Position (INT, 1-based)
variant.ref (char)      Reference allele (VARCHAR, - for missing allele of an
                        insertion)
variant.alt (char)      Alternative allele (VARCHAR, - for missing allele of an
                        deletion)
variant.DP (int)
variant.filter (char)
variant.alt_chr (char)
variant.alt_pos (int)
variant.num (int)       Created from stat &#34;#(alt)&#34;  with type INT on Jul06
variant.hom (int)       Created from stat &#34;#(hom)&#34;  with type INT on Jul06
variant.het (int)       Created from stat &#34;#(het)&#34;  with type INT on Jul06
variant.other (int)     Created from stat &#34;#(other)&#34;  with type INT on Jul06
variant.total (int)     Created from stat &#34;#(GT)&#34;  with type INT on Jul06
variant.maf (float)     Created from stat &#34;maf()&#34;  with type FLOAT on Jul06
variant.minDP (int)     Created from stat &#34;min(DP_geno)&#34;  with type INT on Jul06
variant.maxDP (int)     Created from stat &#34;max(DP_geno)&#34;  with type INT on Jul06
variant.meanDP (float)  Created from stat &#34;avg(DP_geno)&#34;  with type FLOAT on
                        Jul06
variant.numGD10 (int)   Created from stat &#34;#(alt)&#34;  with type INT on Jul06
variant.homGD10 (int)   Created from stat &#34;#(hom)&#34;  with type INT on Jul06
variant.hetGD10 (int)   Created from stat &#34;#(het)&#34;  with type INT on Jul06
variant.otherGD10 (int) 
                        Created from stat &#34;#(other)&#34;  with type INT on Jul06
variant.totalGD10 (int) 
                        Created from stat &#34;#(GT)&#34;  with type INT on Jul06
variant.mafGD10 (float) 
                        Created from stat &#34;maf()&#34;  with type FLOAT on Jul06
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<pre>Name:                   variant
Description:            Master variant table
Creation date:          Jul06
Command:
Fields:                 variant_id, bin, chr, pos, ref, alt, DP, filter,
                        alt_bin, alt_chr, alt_pos, num, hom, het, other, total,
                        maf, minDP, maxDP, meanDP, numGD10, homGD10, hetGD10,
                        otherGD10, totalGD10, mafGD10
Number of variants:     6987
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<p>You will notice the change in genotype counts when applying the filter on genotype depth of coverage and only retaining those genotypes with a read depth greater than 10X. There are now 6976 variant sites after filtering on <code>DP_geno&gt;10</code>. Note that some variant sites will become monomorphic after removing genotypes due to low read depth.</p>
<h3 id="Minor-allele-frequencies-(MAFs)">Minor allele frequencies (MAFs)<a class="anchor-link" href="#Minor-allele-frequencies-(MAFs)"></a></h3><p>In previous steps, we calculated MAFs for each variant site before and after filtering on genotype read depth. Below is a summary of the results:</p>

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<pre>chr	pos     	maf                  	mafGD10
1  	1115503 	0.03508771929824561  	0.05128205128205128
1  	1115548 	0.009433962264150943 	0.01282051282051282
1  	1118275 	0.19230769230769232  	0.18023255813953487
1  	1120377 	0.0056179775280898875	0.0
1  	1120431 	0.228125             	0.2423076923076923
1  	3548136 	0.12012987012987009  	0.15217391304347827
1  	3548832 	0.041025641025641026 	0.043209876543209874
1  	3551737 	0.0056179775280898875	0.006172839506172839
1  	3551792 	0.044444444444444446 	0.05333333333333334
1  	3555351 	0.0056179775280898875	0.005813953488372093
1  	6524501 	0.13114754098360656  	0.14
1  	6524688 	0.05113636363636364  	0.056451612903225805
1  	6524703 	0.011494252873563218 	0.015625
1  	7838196 	0.0056179775280898875	0.006578947368421052
1  	10502369	0.005747126436781609 	0.006756756756756757
1  	11710561	0.1111111111111111   	0.10344827586206896
1  	17914057	0.0755813953488372   	0.0859375
1  	17914122	0.08235294117647059  	0.08064516129032258
1  	17928672	0.00684931506849315  	0.011363636363636364
1  	17949562	0.006172839506172839 	0.009615384615384616
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<p>Adding “<code>&gt; filename.txt</code>” at the end of the above command will write the output to a file.</p>
<p>Next, we examine population specific MAFs. Our data is imported from two files, a CEU dataset (90 samples) and an YRI dataset (112 samples). To calculate allele frequency for each population, let us first assign an additional RACE phenotype (0 for YRI samples and 1 for CEU samples):</p>

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<pre>INFO: Adding phenotype RACE
INFO: 112 values of 1 phenotypes (1 new, 0 existing) of 112 samples are updated.
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<pre>INFO: 90 values of 1 phenotypes (0 new, 1 existing) of 90 samples are updated.
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<pre>sample_name	filename                 	panel             	SEX	BMI   	RACE
NA06984    	CEU.exon...notypes.vcf.gz	ILLUMINA          	1  	36.353	1
NA06985    	CEU.exon...notypes.vcf.gz	.                 	2  	21.415	1
NA06986    	CEU.exon...notypes.vcf.gz	ABI_SOLID+ILLUMINA	1  	26.898	1
NA06989    	CEU.exon...notypes.vcf.gz	ILLUMINA          	2  	25.015	1
NA06994    	CEU.exon...notypes.vcf.gz	ABI_SOLID+ILLUMINA	1  	23.858	1
NA07000    	CEU.exon...notypes.vcf.gz	ABI_SOLID+ILLUMINA	2  	36.226	1
NA07037    	CEU.exon...notypes.vcf.gz	ILLUMINA          	1  	32.513	1
NA07048    	CEU.exon...notypes.vcf.gz	ILLUMINA          	2  	17.57 	1
NA07051    	CEU.exon...notypes.vcf.gz	ILLUMINA          	1  	37.142	1
NA07346    	CEU.exon...notypes.vcf.gz	.                 	2  	30.978	1
(192 records omitted)
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<p>Population specific MAF calculations will be performed using those genotypes that passed the read depth filter (<code>DP_geno&gt;10</code>).</p>

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<pre>INFO: 90 samples are selected
Counting variants: 100% [===============================] 90 221.6/s in 00:00:00
INFO: Adding variant info field CEU_mafGD10 with type FLOAT
Updating variant: 100% [=============================] 3,483 93.3K/s in 00:00:00
INFO: 3483 records are updated
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<pre>INFO: 112 samples are selected
Counting variants: 100% [==============================] 112 274.8/s in 00:00:00
INFO: Adding variant info field YRI_mafGD10 with type FLOAT
Updating variant: 100% [============================] 5,167 113.1K/s in 00:00:00
INFO: 5167 records are updated
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<pre>chr	pos    	mafGD10             	CEU_mafGD10         	YRI_mafGD10
1  	1115503	0.05128205128205128 	0.05128205128205128 	0.0
1  	1115548	0.01282051282051282 	0.01282051282051282 	0.0
1  	1118275	0.18023255813953487 	0.02127659574468085 	0.3717948717948718
1  	1120377	0.0                 	0.0                 	0.0
1  	1120431	0.2423076923076923  	0.025               	0.42857142857142855
1  	3548136	0.15217391304347827 	0.17045454545454541 	0.13541666666666663
1  	3548832	0.043209876543209874	0.08333333333333333 	0.005952380952380952
1  	3551737	0.006172839506172839	0.006172839506172839	0.0
1  	3551792	0.05333333333333334 	0.05333333333333334 	0.0
1  	3555351	0.005813953488372093	0.005813953488372093	0.0
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<p>You will observe zero values because some variant sites are monomorphic or they are population specific.</p>
<h3 id="Sample-level-genotype-summaries">Sample level genotype summaries<a class="anchor-link" href="#Sample-level-genotype-summaries"></a></h3><p>Similar operations could be performed on a sample level instead of on a variant level. More details about obtaining genotype level summary information using <code>vtools phenotype --from_stat</code> can be found at</p>
<p><a href="http://varianttools.sourceforge.net/Vtools/Phenotype">http://varianttools.sourceforge.net/Vtools/Phenotype</a></p>

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<pre>Calculating phenotype: 100% [============================] 90 89.9/s in 00:00:01
INFO: 180 values of 2 phenotypes (2 new, 0 existing) of 90 samples are updated.
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<pre>Calculating phenotype: 100% [==========================] 112 111.9/s in 00:00:01
INFO: 224 values of 2 phenotypes (2 new, 0 existing) of 112 samples are updated.
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<pre>sample_name	CEU_totalGD10	CEU_numGD10	YRI_totalGD10	YRI_numGD10
NA06984	2774	849	NA	NA
NA06985	1944	570	NA	NA
NA06986	3386	1029	NA	NA
NA06989	2659	819	NA	NA
NA06994	1730	486	NA	NA
NA07000	3089	979	NA	NA
NA07037	2990	931	NA	NA
NA07048	3305	1012	NA	NA
NA07051	3402	1130	NA	NA
NA07346	3356	1092	NA	NA
NA07347	3330	1121	NA	NA
NA07357	3373	1063	NA	NA
NA10847	2371	791	NA	NA
NA10851	2408	665	NA	NA
NA11829	3365	1087	NA	NA
NA11830	2935	939	NA	NA
NA11831	3379	1069	NA	NA
NA11832	3398	1149	NA	NA
NA11840	1886	615	NA	NA
NA11843	2400	790	NA	NA
NA11881	2273	698	NA	NA
NA11893	2951	921	NA	NA
NA11918	3297	1044	NA	NA
NA11919	2855	753	NA	NA
NA11920	3365	1129	NA	NA
NA11930	3336	1128	NA	NA
NA11992	3386	1111	NA	NA
NA11994	3370	1095	NA	NA
NA11995	1993	622	NA	NA
NA12003	3328	1062	NA	NA
NA12004	1613	449	NA	NA
NA12005	2973	923	NA	NA
NA12006	1656	484	NA	NA
NA12043	3323	1089	NA	NA
NA12044	2602	791	NA	NA
NA12045	3385	1052	NA	NA
NA12058	2664	837	NA	NA
NA12144	3316	993	NA	NA
NA12154	3114	1028	NA	NA
NA12155	3354	1126	NA	NA
NA12156	1390	380	NA	NA
NA12234	3333	1060	NA	NA
NA12249	2081	638	NA	NA
NA12272	2371	756	NA	NA
NA12273	2319	737	NA	NA
NA12275	2251	725	NA	NA
NA12282	1758	529	NA	NA
NA12283	2459	770	NA	NA
NA12286	2528	785	NA	NA
NA12287	3231	1059	NA	NA
NA12340	2648	820	NA	NA
NA12341	2266	634	NA	NA
NA12342	2666	825	NA	NA
NA12347	3056	927	NA	NA
NA12348	2751	794	NA	NA
NA12383	3356	1082	NA	NA
NA12400	2169	679	NA	NA
NA12413	3387	1095	NA	NA
NA12414	2709	800	NA	NA
NA12489	2888	870	NA	NA
NA12546	3389	1125	NA	NA
NA12716	2617	829	NA	NA
NA12717	2280	724	NA	NA
NA12718	2310	715	NA	NA
NA12748	3302	978	NA	NA
NA12749	3103	935	NA	NA
NA12750	2210	712	NA	NA
NA12751	2202	692	NA	NA
NA12760	2868	890	NA	NA
NA12761	1675	525	NA	NA
NA12762	3184	1026	NA	NA
NA12763	1634	526	NA	NA
NA12775	3228	960	NA	NA
NA12776	3186	1050	NA	NA
NA12812	2244	693	NA	NA
NA12814	2959	940	NA	NA
NA12815	1589	475	NA	NA
NA12828	3274	1051	NA	NA
NA12829	3227	1019	NA	NA
NA12830	3058	914	NA	NA
NA12842	1684	502	NA	NA
NA12843	2832	846	NA	NA
NA12872	1485	425	NA	NA
NA12873	1329	357	NA	NA
NA12874	1802	521	NA	NA
NA12878	3463	1125	NA	NA
NA12889	360	103	NA	NA
NA12890	3394	1089	NA	NA
NA12891	3435	1107	NA	NA
NA12892	3426	1055	NA	NA
NA18486	NA	NA	4718	1180
NA18488	NA	NA	4591	1150
NA18489	NA	NA	3350	685
NA18498	NA	NA	4058	926
NA18499	NA	NA	3408	642
NA18501	NA	NA	4267	1005
NA18504	NA	NA	38	7
NA18508	NA	NA	4036	912
NA18516	NA	NA	86	13
NA18519	NA	NA	4820	1163
NA18520	NA	NA	4886	1176
NA18522	NA	NA	27	3
NA18523	NA	NA	5027	1299
NA18853	NA	NA	4645	1169
NA18856	NA	NA	4958	1282
NA18858	NA	NA	5000	1323
NA18861	NA	NA	4525	1089
NA18865	NA	NA	1294	279
NA18867	NA	NA	4849	1211
NA18868	NA	NA	4430	1079
NA18870	NA	NA	42	5
NA18871	NA	NA	52	10
NA18877	NA	NA	4866	1236
NA18881	NA	NA	4484	1062
NA18907	NA	NA	3826	871
NA18909	NA	NA	3551	767
NA18910	NA	NA	4836	1216
NA18915	NA	NA	4394	1025
NA18916	NA	NA	4378	1009
NA18917	NA	NA	2835	688
NA18923	NA	NA	3042	697
NA18924	NA	NA	3086	697
NA18933	NA	NA	2772	654
NA18934	NA	NA	3079	704
NA19092	NA	NA	4762	1234
NA19095	NA	NA	4012	963
NA19096	NA	NA	4072	912
NA19098	NA	NA	2843	648
NA19102	NA	NA	1908	303
NA19105	NA	NA	4150	953
NA19108	NA	NA	5043	1214
NA19113	NA	NA	4049	987
NA19116	NA	NA	3590	721
NA19117	NA	NA	4092	978
NA19118	NA	NA	4189	998
NA19119	NA	NA	2866	665
NA19121	NA	NA	4364	1061
NA19122	NA	NA	4024	978
NA19130	NA	NA	4570	1153
NA19131	NA	NA	2827	694
NA19133	NA	NA	4688	1146
NA19135	NA	NA	4575	1158
NA19137	NA	NA	1695	381
NA19138	NA	NA	2897	697
NA19141	NA	NA	2615	584
NA19143	NA	NA	3260	772
NA19146	NA	NA	3934	965
NA19149	NA	NA	4187	967
NA19150	NA	NA	4064	940
NA19152	NA	NA	3238	715
NA19153	NA	NA	3279	795
NA19156	NA	NA	4516	1127
NA19157	NA	NA	4773	1166
NA19159	NA	NA	3122	744
NA19163	NA	NA	4371	1069
NA19166	NA	NA	4845	1220
NA19168	NA	NA	4479	1114
NA19171	NA	NA	3168	747
NA19172	NA	NA	4161	949
NA19175	NA	NA	4167	986
NA19179	NA	NA	3969	970
NA19181	NA	NA	2911	696
NA19182	NA	NA	4116	991
NA19184	NA	NA	4140	1004
NA19185	NA	NA	4315	1017
NA19187	NA	NA	4222	995
NA19189	NA	NA	5019	1279
NA19190	NA	NA	4603	1034
NA19195	NA	NA	4450	1093
NA19196	NA	NA	4450	1082
NA19197	NA	NA	3433	875
NA19198	NA	NA	3196	749
NA19200	NA	NA	2990	710
NA19201	NA	NA	2519	592
NA19204	NA	NA	3114	714
NA19206	NA	NA	3056	765
NA19207	NA	NA	2280	525
NA19209	NA	NA	2962	673
NA19210	NA	NA	1350	273
NA19213	NA	NA	4910	1206
NA19214	NA	NA	4214	1020
NA19216	NA	NA	4439	1098
NA19217	NA	NA	4230	1025
NA19220	NA	NA	2690	611
NA19222	NA	NA	5053	1261
NA19223	NA	NA	2720	628
NA19225	NA	NA	5047	1304
NA19229	NA	NA	4813	1228
NA19235	NA	NA	4466	1074
NA19236	NA	NA	4668	1174
NA19238	NA	NA	5027	1271
NA19239	NA	NA	5147	1379
NA19240	NA	NA	5145	1361
NA19247	NA	NA	4606	1108
NA19248	NA	NA	4698	1146
NA19250	NA	NA	4218	1025
NA19253	NA	NA	4964	1248
NA19257	NA	NA	4969	1229
NA19259	NA	NA	4182	1005
NA19260	NA	NA	4404	1076
NA19262	NA	NA	4308	1044
NA19266	NA	NA	4878	1211
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<h2 id="1.4--Variant-Annotation">1.4  Variant Annotation<a class="anchor-link" href="#1.4--Variant-Annotation"></a></h2><p>For rare variant aggregated association tests, we want to focus on analyzing aggregating variants having potential functional contribution to a phenotype. Thus, each variant site needs to be annotated for its functionality. Annotation is performed using <code>variant annotation tools</code> [7] which implements an <code>ANNOVAR</code> pipeline for variant function annotation [9]. More details about the ANNOVAR pipeline can be found at</p>
<p><a href="http://varianttools.sourceforge.net/Pipeline/Annovar">http://varianttools.sourceforge.net/Pipeline/Annovar</a></p>

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<pre>INFO: Executing <span class="ansi-green-fg">ANNOVAR.geneanno_0</span>: Load specified snapshot if a snapshot is specified. Otherwise use the existing project.
INFO: Executing <span class="ansi-green-fg">ANNOVAR.geneanno_10</span>: Check the existence of ANNOVAR&#39;s annotate_variation.pl command.
INFO: Command annotate_variation.pl is located.
INFO: Executing <span class="ansi-green-fg">ANNOVAR.geneanno_11</span>: Determine the humandb path of ANNOVAR
INFO: Running <span class="ansi-green-fg">which annotate_variation.pl &gt; /data/ismb-2018/data/.vtools_cache/annovar.path</span>
INFO: Pipeline variable <span class="ansi-green-fg">HUMANDB</span> is set to <span class="ansi-green-fg">/home/gaow/tmp/29-Jun-2018/annovar/humandb</span>
INFO: Executing <span class="ansi-green-fg">ANNOVAR.geneanno_14</span>: Download gene database for specified --dbtype if they are unavailable
INFO: Reuse existing /home/gaow/tmp/29-Jun-2018/annovar/humandb/hg19_refGene.txt, /home/gaow/tmp/29-Jun-2018/annovar/humandb/hg19_refGeneMrna.fa
INFO: Executing <span class="ansi-green-fg">ANNOVAR.geneanno_20</span>: Export variants in ANNOVAR format
INFO: Running <span class="ansi-green-fg">vtools export variant --format ANNOVAR --output /data/ismb-2018/data/.vtools_cache/annovar_input</span>
INFO: Executing <span class="ansi-green-fg">ANNOVAR.geneanno_30</span>: Execute ANNOVAR annotate_variation.pl --geneanno
INFO: Running <span class="ansi-green-fg">annotate_variation.pl --geneanno --dbtype refGene --buildver hg19 /data/ismb-2018/data/.vtools_cache/annovar_input /home/gaow/tmp/29-Jun-2018/annovar/humandb</span>
INFO: Executing <span class="ansi-green-fg">ANNOVAR.geneanno_40</span>: Importing results from ANNOVAR output .variant_function if --variant_info is specified
INFO: Running <span class="ansi-green-fg">vtools update variant --from_file /data/ismb-2018/data/.vtools_cache/annovar_input.variant_function --format ANNOVAR_variant_function --var_info region_type, region_name</span>
INFO: Using primary reference genome hg19 of the project.
Getting existing variants: 100% [===================] 6,987 645.3K/s in 00:00:00
INFO: Updating variants from /data/ismb-2018/data/.vtools_cache/annovar_input.variant_function (1/1)
annovar_input.variant_function: 100% [================] 6,987 4.9K/s in 00:00:01
INFO: Fields region_type, region_name of 6,987 variants are updated
INFO: Executing <span class="ansi-green-fg">ANNOVAR.geneanno_50</span>: Importing results from ANNOVAR output .exonic_variant_function if --exonic_info is specified
INFO: Running <span class="ansi-green-fg">vtools update variant --from_file /data/ismb-2018/data/.vtools_cache/annovar_input.exonic_variant_function --format ANNOVAR_exonic_variant_function --var_info mut_type, function</span>
INFO: Using primary reference genome hg19 of the project.
Getting existing variants: 100% [===================] 6,987 656.9K/s in 00:00:00
INFO: Updating variants from /data/ismb-2018/data/.vtools_cache/annovar_input.exonic_variant_function (1/1)
annovar_input.exonic_variant_function: 100% [=========] 6,928 4.6K/s in 00:00:01
INFO: Fields mut_type, function of 6,928 variants are updated
INFO: Execution of pipeline ANNOVAR.geneanno is successful with output /data/ismb-2018/data/.vtools_cache/annovar_input.exonic_variant_function
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<p>The following command will output the annotated variant sites to the screen.</p>

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<pre>chr	pos     	ref	alt	mut_type
1  	1115503 	T  	C  	nonsynonymous SNV
1  	1115548 	G  	A  	nonsynonymous SNV
1  	1118275 	C  	T  	synonymous SNV
1  	1120377 	T  	A  	nonsynonymous SNV
1  	1120431 	G  	A  	nonsynonymous SNV
1  	3548136 	T  	C  	synonymous SNV
1  	3548832 	G  	C  	nonsynonymous SNV
1  	3551737 	C  	T  	nonsynonymous SNV
1  	3551792 	G  	A  	synonymous SNV
1  	3555351 	G  	A  	synonymous SNV
1  	6524501 	T  	C  	nonsynonymous SNV
1  	6524688 	T  	C  	synonymous SNV
1  	6524703 	C  	T  	synonymous SNV
1  	7838196 	A  	G  	nonsynonymous SNV
1  	10502369	A  	G  	synonymous SNV
1  	11710561	T  	G  	nonsynonymous SNV
1  	17914057	G  	A  	nonsynonymous SNV
1  	17914122	G  	A  	nonsynonymous SNV
1  	17928672	G  	C  	nonsynonymous SNV
1  	17949562	C  	T  	synonymous SNV
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<p>Many more annotation sources are available which are not covered in this tutorial. Please read</p>
<p><a href="http://varianttools.sourceforge.net/Annotation">http://varianttools.sourceforge.net/Annotation</a></p>
<p>for annotation databases, and</p>
<p><a href="http://varianttools.sourceforge.net/Pipeline">http://varianttools.sourceforge.net/Pipeline</a> for annotation pipelines.</p>
<h2 id="1.5--Data-Quality-Control-(QC)-and-Variant-Selection">1.5  Data Quality Control (QC) and Variant Selection<a class="anchor-link" href="#1.5--Data-Quality-Control-(QC)-and-Variant-Selection"></a></h2><h3 id="Ti/Tv-ratio-evaluations">Ti/Tv ratio evaluations<a class="anchor-link" href="#Ti/Tv-ratio-evaluations"></a></h3><p>Before performing any data QC we examine the transition/transversion (Ti/Tv) ratio for all variant sites. Note that here we are obtaining Ti/Tv ratios for the entire sample, Ti/Tv ratios can also be obtained for each sample.</p>

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<pre>num_of_transition	num_of_transversion	ratio
161,637          	44,641             	3.62082
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<p>The command above counts the number of transition and transversion variants and calculates its ratio. More details about <code>vtools report trans_ratio</code> command can be found at</p>
<p><a href="http://varianttools.sourceforge.net/VtoolsReport/TransRatio">http://varianttools.sourceforge.net/VtoolsReport/TransRatio</a></p>
<p>If only genotype calls having depth of coverage greater than 10 are considered:</p>

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<pre>num_of_transition	num_of_transversion	ratio
140,392          	38,710             	3.62676
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<p>We can see that Ti/Tv ratio has increase slightly if low depth of coverage calls are removed. There is only a small change in the Ti/Tv ratio since only a few variant sites become monomorphic and are no longer included in the calculation. In practice Ti/Tv ratios can be used to evaluate which threshold should be used in data QC.</p>
<h3 id="Removal-of-low-quality-variant-sites">Removal of low quality variant sites<a class="anchor-link" href="#Removal-of-low-quality-variant-sites"></a></h3><p>We should not need to remove any variant site based on read depth because all variants passed the quality filter. To demonstrate removal of variant sites, let us remove those with a total read depth <code>DP&lt;15</code>:</p>

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<pre>Running: 2 1.1K/s in 00:00:00
INFO: 1 variants selected.
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<pre>table        #variants     date message
to_remove            1    Jul06
variant          6,987    Jul06 Master variant table
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<pre>table      #variants     date message
variant        6,986    Jul06 Master variant table
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<p>We can see that one variant site has been removed from master variant table. The <code>vtools remove</code> command can remove various items from the current project. More details about <code>vtools remove</code> command can be found at:</p>
<p><a href="http://varianttools.sourceforge.net/Vtools/Remove">http://varianttools.sourceforge.net/Vtools/Remove</a></p>
<p>Using a combination of select/remove subcommands low quality variant sites can be easily filtered out. The <code>vtools show fields</code>, <code>vtools show tables</code>, and <code>vtools show table variant</code> commands will allow you to see the new/updated fields and tables you have added/changed to the project.</p>
<h3 id="Filter-genotype-calls-by-quality">Filter genotype calls by quality<a class="anchor-link" href="#Filter-genotype-calls-by-quality"></a></h3><p>We have calculated various summary statistics using the command <code>--genotypes CONDITION</code> but we have not yet removed genotypes having genotype read depth of coverage lower than 10X. The command below removes these genotypes.</p>

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<h3 id="Select-variants-by-annotated-functionality">Select variants by annotated functionality<a class="anchor-link" href="#Select-variants-by-annotated-functionality"></a></h3><p>To select potentially functional variants for association mapping:</p>

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<pre>Running: 10 2.3K/s in 00:00:00
INFO: 3524 variants selected.
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<pre>table      #variants     date message
v_funct        3,524    Jul06
variant        6,986    Jul06 Master variant table
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<p>The command above selects variant sites that are either nonsynonymous (by condition <code>mut_type like ’non%’</code>) or stop-gain/stop-loss (by condition <code>mut_type like ’stop%’</code>) or alternative splicing (by condition <code>region-type=’splicing’</code>)</p>
<p>3367 functional variant sites are selected.</p>

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<h1 id="Part-II:-Association-Tests-for-Quantitative-Traits">Part II: Association Tests for Quantitative Traits<a class="anchor-link" href="#Part-II:-Association-Tests-for-Quantitative-Traits"></a></h1><h2 id="2.1--View-phenotype-data">2.1  View phenotype data<a class="anchor-link" href="#2.1--View-phenotype-data"></a></h2>
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<pre>sample_name	filename                 	panel             	SEX	BMI   	RACE	CEU_totalGD10	CEU_numGD10	YRI_totalGD10	YRI_numGD10
NA06984    	CEU.exon...notypes.vcf.gz	ILLUMINA          	1  	36.353	1   	2774         	849        	.            	.
NA06985    	CEU.exon...notypes.vcf.gz	.                 	2  	21.415	1   	1944         	570        	.            	.
NA06986    	CEU.exon...notypes.vcf.gz	ABI_SOLID+ILLUMINA	1  	26.898	1   	3386         	1029       	.            	.
NA06989    	CEU.exon...notypes.vcf.gz	ILLUMINA          	2  	25.015	1   	2659         	819        	.            	.
NA06994    	CEU.exon...notypes.vcf.gz	ABI_SOLID+ILLUMINA	1  	23.858	1   	1730         	486        	.            	.
(197 records omitted)
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<h2 id="2.2--Analysis-plan">2.2  Analysis plan<a class="anchor-link" href="#2.2--Analysis-plan"></a></h2><p>We want to carry out the association analysis for CEU and YRI separately. For starters we demonstrate analysis of CEU samples; and the same commands will be applicable for YRI samples. After completing the analysis of CEU samples please use the same commands to analyze the YRI data set. You should not analyze the data from different populations together, once you have the p-values from each analysis, you may perform a meta-analysis.</p>
<h2 id="2.3--Subset-data-by-MAFs">2.3  Subset data by MAFs<a class="anchor-link" href="#2.3--Subset-data-by-MAFs"></a></h2><p>To carry out association tests we need to treat common and rare variants separately. The dataset for our tutorial has very small sample size, but with large sample size it is reasonable to define rare variants as having observed MAF&lt;0.01, and common variants as variants having observed MAF$\ge$0.05. First, we create variant tables based on calculated alternative allele frequencies for both populations</p>

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<pre>INFO: 90 samples are selected by condition: RACE=1
Collecting sample variants: 100% [=======================] 90 2.1K/s in 00:00:00
Running: 6 1.3K/s in 00:00:00
INFO: 1450 variants selected.
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<pre>INFO: 90 samples are selected by condition: RACE=1
Collecting sample variants: 100% [=======================] 90 2.1K/s in 00:00:00
Running: 6 1.3K/s in 00:00:00
INFO: 602 variants selected.
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<p>Notice that for selection of rare variants we only keep those that are annotated as functional (chosen from <code>v_funct</code> table). There are 1450 and 604 variant sites selected for MAF0.05 and MAF&lt;0.01, respectively.</p>
<h2 id="2.4--Annotate-variants-to-genes">2.4  Annotate variants to genes<a class="anchor-link" href="#2.4--Annotate-variants-to-genes"></a></h2><p>For gene based rare variant analysis we need annotations that tell us the boundaries of genes. We use the refGene annotation database for this purpose.</p>

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<pre>Binning ranges: 100% [=============================] 41,302 211.3K/s in 00:00:00
INFO: Using annotation DB refGene as refGene in project VATDemo.
INFO: refseq Genes
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<pre>Annotation database refGene (version hg19_20110909)
Description:            refseq Genes
Database type:          range
Reference genome hg19:  chr, txStart, txEnd
  name (char)           Gene name
  chr (char)
  strand (char)         which DNA strand contains the observed alleles
  txStart (int)         Transcription start position
  txEnd (int)           Transcription end position
  cdsStart (int)        Coding region start
  cdsEnd (int)          Coding region end
  exonCount (int)       Number of exons
  score (int)           Score
  name2 (char)          Alternative name
  cdsStartStat (char)   cds start stat, can be &#39;non&#39;, &#39;unk&#39;, &#39;incompl&#39;, and
                        &#39;cmp1&#39;
  cdsEndStat (char)     cds end stat, can be &#39;non&#39;, &#39;unk&#39;, &#39;incompl&#39;, and &#39;cmp1&#39;
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<p>The names of genes are contained in the <code>refGene.name2</code> field. The <code>vtools use</code> command, attaches an annotation database to the project, effectively incorporating one or more attributes available to variants in the project. More details about <code>vtools use</code> command can be found at</p>
<p><a href="http://varianttools.sourceforge.net/Vtools/Use">http://varianttools.sourceforge.net/Vtools/Use</a></p>

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<h2 id="2.5--Association-testing-of-common/rare-variants">2.5  Association testing of common/rare variants<a class="anchor-link" href="#2.5--Association-testing-of-common/rare-variants"></a></h2><p>The association test program suite is implemented as the <code>vtools associate</code> subcommand. To list available association test options</p>

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<pre>usage: vtools associate [-h] [--covariates [COVARIATES [COVARIATES ...]]]
                        [--var_info [VAR_INFO [VAR_INFO ...]]]
                        [--geno_info [GENO_INFO [GENO_INFO ...]]]
                        [--geno_name GENO_NAME] [-m METHODS [METHODS ...]]
                        [-g [GROUP_BY [GROUP_BY ...]]] [-s [COND [COND ...]]]
                        [--genotypes [COND [COND ...]]]
                        [--discard_samples [EXPR [EXPR ...]]]
                        [--discard_variants [EXPR [EXPR ...]]]
                        [--to_db annoDB] [-d DELIMITER] [-f] [-j N]
                        [-v {0,1,2,3}]
                        variants phenotypes

Call one or more statistical association tests and return test results as
fields to variants tested.

optional arguments:
  -h, --help            show this help message and exit
  -j N, --jobs N        Number of processes to carry out association tests.
  -v {0,1,2,3}, --verbosity {0,1,2,3}
                        Output error and warning (0), info (1), debug (2) and
                        trace (3) information to standard output (default to
                        1).

Genotype, phenotype, and covariates:
  variants              Table of variants to be tested.
  phenotypes            A list of phenotypes that will be passed to the
                        association statistics calculator. Currently only a
                        single phenotype is allowed.
  --covariates [COVARIATES [COVARIATES ...]]
                        Optional phenotypes that will be passed to statistical
                        tests as covariates. Values of these phenotypes should
                        be integer or float.
  --var_info [VAR_INFO [VAR_INFO ...]]
                        Optional variant information fields (e.g. minor allele
                        frequency from 1000 genomes project) that will be
                        passed to statistical tests. The fields could be any
                        annotation fields of with integer or float values,
                        including those from used annotation databases (use
                        &#34;vtools show fields&#34; to see a list of usable fields).
  --geno_info [GENO_INFO [GENO_INFO ...]]
                        Optional genotype fields (e.g. quality score of
                        genotype calls, cf. &#34;vtools show genotypes&#34;) that will
                        be passed to statistical tests. Note that the fields
                        should exist for all samples that are tested.
  --geno_name GENO_NAME
                        Field name of genotype, default to &#39;GT&#39;. If another
                        field name is specified, for example if imputation
                        scores are available as &#39;DS&#39; (dosage), then the given
                        field &#39;DS&#39; will be used as genotype data for
                        association analysis.

Association tests:
  -m METHODS [METHODS ...], --methods METHODS [METHODS ...]
                        Method of one or more association tests. Parameters
                        for each method should be specified together as a
                        quoted long argument (e.g. --methods &#34;m --alternative
                        2&#34; &#34;m1 --permute 1000&#34;), although the common method
                        parameters can be specified separately, as long as
                        they do not conflict with command arguments. (e.g.
                        --methods m1 m2 -p 1000 is equivalent to --methods &#34;m1
                        -p 1000&#34; &#34;m2 -p 1000&#34;.). You can use command &#39;vtools
                        show tests&#39; for a list of association tests, and
                        &#39;vtools show test TST&#39; for details about a test.
                        Customized association tests can be specified as
                        mod_name.test_name where mod_name should be a Python
                        module (system wide or in the current directory), and
                        test_name should be a subclass of NullTest.
  -g [GROUP_BY [GROUP_BY ...]], --group_by [GROUP_BY [GROUP_BY ...]]
                        Group variants by fields. If specified, variants will
                        be separated into groups and are tested one by one.

Select and filter samples and genotypes:
  -s [COND [COND ...]], --samples [COND [COND ...]]
                        Limiting variants from samples that match conditions
                        that use columns shown in command &#39;vtools show sample&#39;
                        (e.g. &#39;aff=1&#39;, &#39;filename like &#34;MG%&#34;&#39;). Each line of
                        the sample table (vtools show samples) is considered
                        as samples. If genotype of a physical sample is
                        scattered into multiple samples (e.g. imported
                        chromosome by chromosome), they should be merged using
                        command vtools admin.
  --genotypes [COND [COND ...]]
                        Limiting genotypes to those matching conditions that
                        use columns shown in command &#39;vtools show genotypes&#39;
                        (e.g. &#39;GQ&gt;15&#39;). Genotypes failing such conditions will
                        be regarded as missing genotypes.
  --discard_samples [EXPR [EXPR ...]]
                        Discard samples that match specified conditions within
                        each test group (defined by parameter --group_by).
                        Currently only expressions in the form of &#34;%(NA)&gt;p&#34; is
                        providedted to remove samples that have more 100*p
                        percent of missing values.
  --discard_variants [EXPR [EXPR ...]]
                        Discard variant sites based on specified conditions
                        within each test group. Currently only expressions in
                        the form of &#39;%(NA)&gt;p&#39; is provided to remove variant
                        sites that have more than 100*p percent of missing
                        genotypes. Note that this filter will be applied after
                        &#34;--discard_samples&#34; is applied, if the latter also is
                        specified.

Output of test statistics:
  --to_db annoDB        Name of a database to which results from association
                        tests will be written. Groups with existing results in
                        the database will be ignored unless parameter --force
                        is used.
  -d DELIMITER, --delimiter DELIMITER
                        Delimiter use to separate columns of output. The
                        default output uses multiple spaces to align columns
                        of output. Use &#39;-d,&#39; for csv output, or -d&#39;\t&#39; for
                        tab-delimited output.
  -f, --force           Analyze all groups including those that have recorded
                        results in the result database.
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<pre>BurdenBt                Burden test for disease traits, Morris &amp; Zeggini 2009
BurdenQt                Burden test for quantitative traits, Morris &amp; Zeggini
                        2009
CFisher                 Fisher&#39;s exact test on collapsed variant loci, Li &amp; Leal
                        2008
Calpha                  c-alpha test for unusual distribution of variants
                        between cases and controls, Neale et al 2011
CollapseBt              Collapsing method for disease traits, Li &amp; Leal 2008
CollapseQt              Collapsing method for quantitative traits, Li &amp; Leal
                        2008
GroupStat               Calculates basic statistics for each testing group
GroupWrite              Write data to disk for each testing group
KBAC                    Kernel Based Adaptive Clustering method, Liu &amp; Leal 2010
LinRegBurden            A versatile framework of association tests for
                        quantitative traits
LogitRegBurden          A versatile framework of association tests for disease
                        traits
RBT                     Replication Based Test for protective and deleterious
                        variants, Ionita-Laza et al 2011
RTest                   A general framework for association analysis using R
                        programs
RareCover               A &#34;covering&#34; method for detecting rare variants
                        association, Bhatia et al 2010.
SKAT                    SKAT (Wu et al 2011) and SKAT-O (Lee et al 2012)
SSeq_common             Score statistic / SCORE-Seq software (Tang &amp; Lin 2011),
                        for common variants analysis
SSeq_rare               Score statistic / SCORE-Seq software (Tang &amp; Lin 2011),
                        for rare variants analysis
VATStacking             VAT stacking with resampling-based p-value adjustment
                        for applying many algorithms
VTtest                  VT statistic for disease traits, Price et al 2010
VariableThresholdsBt    Variable thresholds method for disease traits, in the
                        spirit of Price et al 2010
VariableThresholdsQt    Variable thresholds method for quantitative traits, in
                        the spirit of Price et al 2010
WSSRankTest             Weighted sum method using rank test statistic, Madsen &amp;
                        Browning 2009
WeightedBurdenBt        Weighted genotype burden tests for disease traits, using
                        one or many arbitrary external weights as well as one of
                        4 internal weighting themes
WeightedBurdenQt        Weighted genotype burden tests for quantitative traits,
                        using one or many arbitrary external weights as well as
                        one of 4 internal weighting themes
aSum                    Adaptive Sum score test for protective and deleterious
                        variants, Han &amp; Pan 2010
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<pre>Name:          LinRegBurden
Description:   A versatile framework of association tests for quantitative traits
usage: vtools associate --method LinRegBurden [-h] [--name NAME]
                                              [-q1 MAFUPPER] [-q2 MAFLOWER]
                                              [--alternative TAILED]
                                              [--use_indicator] [-p N]
                                              [--permute_by XY] [--adaptive C]
                                              [--variable_thresholds]
                                              [--extern_weight [EXTERN_WEIGHT [EXTERN_WEIGHT ...]]]
                                              [--weight {Browning_all,Browning,KBAC,RBT}]
                                              [--NA_adjust]
                                              [--moi {additive,dominant,recessive}]

Linear regression test. p-value is based on the significance level of the
regression coefficient for genotypes. If --group_by option is specified, it
will collapse the variants within a group into a generic genotype score

optional arguments:
  -h, --help            show this help message and exit
  --name NAME           Name of the test that will be appended to names of
                        output fields, usually used to differentiate output of
                        different tests, or the same test with different
                        parameters.
  -q1 MAFUPPER, --mafupper MAFUPPER
                        Minor allele frequency upper limit. All variants
                        having sample MAF&lt;=m1 will be included in analysis.
                        Default set to 1.0
  -q2 MAFLOWER, --maflower MAFLOWER
                        Minor allele frequency lower limit. All variants
                        having sample MAF&gt;m2 will be included in analysis.
                        Default set to 0.0
  --alternative TAILED  Alternative hypothesis is one-sided (&#34;1&#34;) or two-sided
                        (&#34;2&#34;). Default set to 1
  --use_indicator       This option, if evoked, will apply binary coding to
                        genotype groups (coding will be &#34;1&#34; if ANY locus in
                        the group has the alternative allele, &#34;0&#34; otherwise)
  -p N, --permutations N
                        Number of permutations
  --permute_by XY       Permute phenotypes (&#34;Y&#34;) or genotypes (&#34;X&#34;). Default
                        is &#34;Y&#34;
  --adaptive C          Adaptive permutation using Edwin Wilson 95 percent
                        confidence interval for binomial distribution. The
                        program will compute a p-value every 1000 permutations
                        and compare the lower bound of the 95 percent CI of
                        p-value against &#34;C&#34;, and quit permutations with the
                        p-value if it is larger than &#34;C&#34;. It is recommended to
                        specify a &#34;C&#34; that is slightly larger than the
                        significance level for the study. To disable the
                        adaptive procedure, set C=1. Default is C=0.1
  --variable_thresholds
                        This option, if evoked, will apply variable thresholds
                        method to the permutation routine in burden test on
                        aggregated variant loci
  --extern_weight [EXTERN_WEIGHT [EXTERN_WEIGHT ...]]
                        External weights that will be directly applied to
                        genotype coding. Names of these weights should be in
                        one of &#39;--var_info&#39; or &#39;--geno_info&#39;. If multiple
                        weights are specified, they will be applied to
                        genotypes sequentially. Note that all weights will be
                        masked if --use_indicator is evoked.
  --weight {Browning_all,Browning,KBAC,RBT}
                        Internal weighting themes inspired by various
                        association methods. Valid choices are:
                        &#39;Browning_all&#39;, &#39;Browning&#39;, &#39;KBAC&#39; and &#39;RBT&#39;. Except
                        for &#39;Browning_all&#39; weighting, tests using all other
                        weighting themes has to calculate p-value via
                        permutation. For details of the weighting themes,
                        please refer to the online documentation.
  --NA_adjust           This option, if evoked, will replace missing genotype
                        values with a score relative to sample allele
                        frequencies. The association test will be adjusted to
                        incorporate the information. This is an effective
                        approach to control for type I error due to
                        differential degrees of missing genotypes among
                        samples.
  --moi {additive,dominant,recessive}
                        Mode of inheritance. Will code genotypes as 0/1/2/NA
                        for additive mode, 0/1/NA for dominant or recessive
                        mode. Default set to additive
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<p>Note that we use the quantitative trait BMI as the phenotype, and we will account for “SEX” as a covariate in the regression framework. More details about <code>vtools associate</code> command can be found at</p>
<p><a href="http://varianttools.sourceforge.net/Vtools/Associate">http://varianttools.sourceforge.net/Vtools/Associate</a></p>
<h3 id="Analysis-of-common-variants">Analysis of common variants<a class="anchor-link" href="#Analysis-of-common-variants"></a></h3><p>By default, the program will perform single variant tests using a simple linear model, and the Wald test statistic will be evaluated for p-values:</p>

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<pre>INFO: 90 samples are selected by condition: (RACE=1)
INFO: 1450 groups are found
Loading genotypes: 100% [================================] 90 79.2/s in 00:00:01
Testing for association: 100% [====================] 1,450/<span class="ansi-red-intense-fg ansi-bold">5</span> 645.0/s in 00:00:02
INFO: Association tests on 1450 groups have completed. 5 failed.
INFO: Using annotation DB EA_CV as EA_CV in project VATDemo.
INFO: Annotation database used to record results of association tests. Created on Fri, 06 Jul 2018 16:03:42
INFO: 1450 out of 6986 variant.chr, variant.pos are annotated through annotation database EA_CV
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<p>Option <code>-j1</code> specifies that 1 CPU core be used for association testing. You may use larger number of jobs for real world data analysis, e.g., use <code>-j16</code> if your computational resources has 16 CPU cores available. Linux command <code>cat /proc/cpuinfo</code> shows the number of cores and other information related to the CPU on your computer.</p>
<p>The following command displays error messages about the failed tests. In each case, the sample size was too small to perform the regression analysis.</p>

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<pre>2018-07-06 11:03:47,381: DEBUG: An ERROR has occurred in process 0 while processing &#39;6:29910604&#39;: Sample size too small (2) to be analyzed for &#39;6:29910604&#39;.
2018-07-06 11:03:47,386: DEBUG: An ERROR has occurred in process 0 while processing &#39;6:29910742&#39;: Sample size too small (2) to be analyzed for &#39;6:29910742&#39;.
2018-07-06 11:03:47,607: DEBUG: An ERROR has occurred in process 0 while processing &#39;7:148921732&#39;: Sample size too small (2) to be analyzed for &#39;7:148921732&#39;.
2018-07-06 11:03:47,700: DEBUG: An ERROR has occurred in process 0 while processing &#39;8:145747920&#39;: Sample size too small (4) to be analyzed for &#39;8:145747920&#39;.
2018-07-06 11:03:47,707: DEBUG: An ERROR has occurred in process 0 while processing &#39;9:215057&#39;: Sample size too small (4) to be analyzed for &#39;9:215057&#39;.
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<p>A summary from the association test is written to the file <code>EA_CV.asso.res</code>. The first column indicates the variant chromosome and base pair position so that you may follow up on the top signals using various annotation sources that we will not introduce in this tutorial. The result will be automatically built into annotation database if <code>--to_db</code> option is specified.</p>

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<pre>variant_chr	variant_pos	sample_size_LinRegBurden	num_variants_LinRegBurden	total_mac_LinRegBurden	beta_x_LinRegBurden	pvalue_LinRegBurden	wald_x_LinRegBurden	beta_2_LinRegBurden	beta_2_pvalue_LinRegBurden	wald_2_LinRegBurden
1          	1115503    	39                      	1                        	4                     	-3.79867           	0.303847           	-1.04312           	1.81933            	0.423273                  	0.809982
1          	3548136    	44                      	1                        	15                    	1.87087            	0.374567           	0.897738           	0.0423982          	0.984496                  	0.0195514
1          	3548832    	78                      	1                        	13                    	1.29502            	0.562724           	0.581386           	-0.753517          	0.651351                  	-0.453706
1          	3551792    	75                      	1                        	8                     	4.31445            	0.102654           	1.65315            	-1.38652           	0.3924                    	-0.860446
1          	6524501    	62                      	1                        	10                    	1.10259            	0.671892           	0.425678           	-1.16366           	0.544558                  	-0.609463
1          	6524688    	63                      	1                        	7                     	-1.34283           	0.632522           	-0.480637          	0.376518           	0.831142                  	0.214169
1          	11710561   	38                      	1                        	9                     	0.0203366          	0.992064           	0.0100182          	2.19027            	0.370985                  	0.906279
1          	17914057   	68                      	1                        	11                    	-2.23783           	0.387371           	-0.870241          	-1.0346            	0.588188                  	-0.544168
1          	17914122   	64                      	1                        	11                    	3.03457            	0.240427           	1.18548            	-1.02577           	0.600161                  	-0.526919
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<p>To sort the results by p-value and output the first 10 lines of the file use the command:</p>

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<pre>variant_chr	variant_pos	sample_size_LinRegBurden	num_variants_LinRegBurden	total_mac_LinRegBurden	beta_x_LinRegBurden	pvalue_LinRegBurden	wald_x_LinRegBurden	beta_2_LinRegBurden	beta_2_pvalue_LinRegBurden	wald_2_LinRegBurden
11         	108383676  	88                      	1                        	25                    	6.53168            	0.000105185        	4.06922            	0.0735287          	0.961696                  	0.0481674
19         	16008257   	54                      	1                        	17                    	7.31337            	0.00038548         	3.80137            	1.45651            	0.466234                  	0.734125
16         	57735900   	71                      	1                        	41                    	-5.19002           	0.000386273        	-3.73498           	0.570017           	0.721588                  	0.357818
19         	16008388   	34                      	1                        	9                     	6.97057            	0.00279873         	3.24718            	2.8695             	0.200913                  	1.30674
19         	16006413   	47                      	1                        	13                    	6.7213             	0.002973           	3.14519            	0.614935           	0.775703                  	0.28668
9          	35792423   	32                      	1                        	15                    	6.60852            	0.00564457         	2.98954            	0.820153           	0.714935                  	0.368829
2          	49191041   	88                      	1                        	73                    	3.34503            	0.00656039         	2.78702            	0.947342           	0.552026                  	0.597102
17         	33768354   	44                      	1                        	42                    	-4.13311           	0.00686359         	-2.84707           	-2.08353           	0.319621                  	-1.00746
8          	121215991  	86                      	1                        	77                    	-3.34412           	0.00722408         	-2.75438           	0.63102            	0.697061                  	0.390644
sort: write failed: standard output: Broken pipe
sort: write error
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<p>If you obtain significant p-values be sure to also observe the accompanying sample size. Significant p-values from too small of a sample size may not be results you can trust.</p>
<p>Also, depending on your phenotype you may have to add additional covariates to your analysis. VAT allows you to test many different models for the various phenotypes and covariates. P-values for covariates are also reported.</p>
<p>Similar to using an annotation database, you can use the results from the association test to annotate the project and follow up variants of interest, for example:</p>

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<pre>variant.chr (char)      Chromosome name (VARCHAR)
variant.pos (int)       Position (INT, 1-based)
variant.ref (char)      Reference allele (VARCHAR, - for missing allele of an
                        insertion)
variant.alt (char)      Alternative allele (VARCHAR, - for missing allele of an
                        deletion)
variant.DP (int)
variant.filter (char)
variant.alt_chr (char)
variant.alt_pos (int)
variant.num (int)       Created from stat &#34;#(alt)&#34;  with type INT on Jul06
variant.hom (int)       Created from stat &#34;#(hom)&#34;  with type INT on Jul06
variant.het (int)       Created from stat &#34;#(het)&#34;  with type INT on Jul06
variant.other (int)     Created from stat &#34;#(other)&#34;  with type INT on Jul06
variant.total (int)     Created from stat &#34;#(GT)&#34;  with type INT on Jul06
variant.maf (float)     Created from stat &#34;maf()&#34;  with type FLOAT on Jul06
variant.minDP (int)     Created from stat &#34;min(DP_geno)&#34;  with type INT on Jul06
variant.maxDP (int)     Created from stat &#34;max(DP_geno)&#34;  with type INT on Jul06
variant.meanDP (float)  Created from stat &#34;avg(DP_geno)&#34;  with type FLOAT on
                        Jul06
variant.numGD10 (int)   Created from stat &#34;#(alt)&#34;  with type INT on Jul06
variant.homGD10 (int)   Created from stat &#34;#(hom)&#34;  with type INT on Jul06
variant.hetGD10 (int)   Created from stat &#34;#(het)&#34;  with type INT on Jul06
variant.otherGD10 (int) 
                        Created from stat &#34;#(other)&#34;  with type INT on Jul06
variant.totalGD10 (int) 
                        Created from stat &#34;#(GT)&#34;  with type INT on Jul06
variant.mafGD10 (float) 
                        Created from stat &#34;maf()&#34;  with type FLOAT on Jul06
variant.CEU_mafGD10 (float) 
                        Created from stat &#34;maf()&#34; for samples [&#39;RACE=1&#39;] with
                        type FLOAT on Jul06
variant.YRI_mafGD10 (float) 
                        Created from stat &#34;maf()&#34; for samples [&#39;RACE=0&#39;] with
                        type FLOAT on Jul06
variant.region_type (char)
variant.region_name (char)
variant.mut_type (char)
variant.function (char)
refGene.name (char)     Gene name
refGene.chr (char)
refGene.strand (char)   which DNA strand contains the observed alleles
refGene.txStart (int)   Transcription start position
refGene.txEnd (int)     Transcription end position
refGene.cdsStart (int)  Coding region start
refGene.cdsEnd (int)    Coding region end
refGene.exonCount (int) Number of exons
refGene.score (int)     Score
refGene.name2 (char)    Alternative name
refGene.cdsStartStat (char)
                        cds start stat, can be &#39;non&#39;, &#39;unk&#39;, &#39;incompl&#39;, and
                        &#39;cmp1&#39;
refGene.cdsEndStat (char)
                        cds end stat, can be &#39;non&#39;, &#39;unk&#39;, &#39;incompl&#39;, and &#39;cmp1&#39;
EA_CV.variant_chr (char)
                        variant_chr
EA_CV.variant_pos (int) variant_pos
EA_CV.sample_size_LinRegBurden (int)
                        sample size
EA_CV.num_variants_LinRegBurden (int)
                        number of variants in each group (adjusted for specified
                        MAF upper/lower bounds)
EA_CV.total_mac_LinRegBurden (int)
                        total minor allele counts in a group (adjusted for MOI)
EA_CV.beta_x_LinRegBurden (float)
                        test statistic. In the context of regression this is
                        estimate of effect size for x
EA_CV.pvalue_LinRegBurden (float)
                        p-value
EA_CV.wald_x_LinRegBurden (float)
                        Wald statistic for x (beta_x/SE(beta_x))
EA_CV.beta_2_LinRegBurden (float)
                        estimate of beta for covariate 2
EA_CV.beta_2_pvalue_LinRegBurden (float)
                        p-value for covariate 2
EA_CV.wald_2_LinRegBurden (float)
                        Wald statistic for covariate 2
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<p>You see additional annotation fields starting with EA CV, the name of the annotation database you just created from association test (if you used the --to db option mentioned above). You can use them to easily select/output variants of interest. More details about outputting annotation fields for significant findings can be found at</p>
<p><a href="http://varianttools.sourceforge.net/Vtools/Output">http://varianttools.sourceforge.net/Vtools/Output</a></p>
<h3 id="Burden-test-for-rare-variants-(BRV)">Burden test for rare variants (BRV)<a class="anchor-link" href="#Burden-test-for-rare-variants-(BRV)"></a></h3><p>BRV method uses the count of rare variants in given genetic region for association analysis, regardless of the region length.</p>
<p>We use the <code>-g</code> option and use the ‘refGene.name2’ field to define the boundaries of a gene. By default, the test is a linear regression using aggregated counts of variants in a gene region as the regressor.</p>

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      class="sos-source" name="Bash">vtools associate rare_ceu BMI --covariate SEX --samples "RACE=1" -m "LinRegBurden --alternative 2" -g refGene.name2 -j1 --to_db EA_RV  > EA_RV.asso.res</textarea>
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<pre>INFO: 90 samples are selected by condition: (RACE=1)
INFO: 404 groups are found
Loading genotypes: 100% [===============================] 90 299.7/s in 00:00:00
Testing for association: 100% [=====================] 404/<span class="ansi-red-intense-fg ansi-bold">13</span> 640.5/s in 00:00:00
INFO: Association tests on 404 groups have completed. 13 failed.
INFO: Using annotation DB EA_RV as EA_RV in project VATDemo.
INFO: Annotation database used to record results of association tests. Created on Fri, 06 Jul 2018 16:05:00
INFO: 404 out of 23269 refGene.refGene.name2 are annotated through annotation database EA_RV
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<p>Association tests on 404 groups have completed. 13 failed. To view failed tests:</p>

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<pre>2018-06-29 17:33:20,124: DEBUG: An ERROR has occurred in process 0 while processing &#39;BCL2L15&#39;: No variant found in genotype data for &#39;BCL2L15&#39;.
2018-06-29 17:33:20,181: DEBUG: An ERROR has occurred in process 0 while processing &#39;CDHR5&#39;: No variant found in genotype data for &#39;CDHR5&#39;.
2018-06-29 17:33:20,189: DEBUG: An ERROR has occurred in process 0 while processing &#39;CERS3&#39;: No variant found in genotype data for &#39;CERS3&#39;.
2018-06-29 17:33:20,213: DEBUG: An ERROR has occurred in process 0 while processing &#39;CTSW&#39;: No variant found in genotype data for &#39;CTSW&#39;.
2018-06-29 17:33:20,366: DEBUG: An ERROR has occurred in process 0 while processing &#39;LOC100287722&#39;: No variant found in genotype data for &#39;LOC100287722&#39;.
2018-06-29 17:33:20,420: DEBUG: An ERROR has occurred in process 0 while processing &#39;NOM1&#39;: Sample size too small (1) to be analyzed for &#39;NOM1&#39;.
2018-06-29 17:33:20,438: DEBUG: An ERROR has occurred in process 0 while processing &#39;OR10J1&#39;: No variant found in genotype data for &#39;OR10J1&#39;.
2018-06-29 17:33:20,531: DEBUG: An ERROR has occurred in process 0 while processing &#39;PRG3&#39;: No variant found in genotype data for &#39;PRG3&#39;.
2018-06-29 17:33:20,645: DEBUG: An ERROR has occurred in process 0 while processing &#39;SULT1A1&#39;: No variant found in genotype data for &#39;SULT1A1&#39;.
2018-06-29 17:33:20,670: DEBUG: An ERROR has occurred in process 0 while processing &#39;TMCC1&#39;: No variant found in genotype data for &#39;TMCC1&#39;.
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<p>The output file is <code>EA_RV.asso.res</code>. The first column is the gene name, with corresponding p-values in the sixth column for the entire gene.</p>

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<pre>refgene_name2	sample_size_LinRegBurden	num_variants_LinRegBurden	total_mac_LinRegBurden	beta_x_LinRegBurden	pvalue_LinRegBurden	wald_x_LinRegBurden	beta_2_LinRegBurden	beta_2_pvalue_LinRegBurden	wald_2_LinRegBurden
AATF         	89                      	3                        	3                     	4.06571            	0.371806           	0.897786           	0.819087           	0.617609                  	0.501059
ABCB9        	58                      	1                        	1                     	4.29374            	0.561422           	0.584278           	0.0901042          	0.962807                  	0.0468439
ABLIM3       	90                      	2                        	2                     	-7.83832           	0.158126           	-1.42364           	0.466136           	0.774715                  	0.287105
ACCN3        	56                      	1                        	1                     	9.84035            	0.17451            	1.37632            	-1.2081            	0.530485                  	-0.631412
ACHE         	76                      	1                        	1                     	1.51292            	0.845698           	0.195304           	-0.186314          	0.916242                  	-0.105534
ACTL8        	81                      	2                        	2                     	-4.82112           	0.378176           	-0.886308          	0.25399            	0.88081                   	0.150435
ADAM29       	88                      	1                        	1                     	-6.52372           	0.403205           	-0.840108          	0.850198           	0.606861                  	0.516479
ADAMTS4      	69                      	1                        	1                     	0.171944           	0.981712           	0.0230098          	-0.771931          	0.667839                  	-0.431047
AHNAK        	89                      	4                        	4                     	-1.18887           	0.764332           	-0.300749          	0.914744           	0.578008                  	0.55842
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<p>You can also sort these results by p-value using command:</p>

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<pre>refgene_name2	sample_size_LinRegBurden	num_variants_LinRegBurden	total_mac_LinRegBurden	beta_x_LinRegBurden	pvalue_LinRegBurden	wald_x_LinRegBurden	beta_2_LinRegBurden	beta_2_pvalue_LinRegBurden	wald_2_LinRegBurden
CIDEA        	73                      	1                        	1                     	20.294             	0.00504822         	2.89536            	-0.235139          	0.885684                  	-0.144293
SPP2         	90                      	2                        	2                     	15.0031            	0.00549521         	2.8476             	0.792108           	0.611456                  	0.509838
WNT16        	88                      	1                        	1                     	20.703             	0.00683376         	2.77254            	1.17245            	0.460926                  	0.740684
CRTAP        	77                      	1                        	1                     	20.4367            	0.00723434         	2.76236            	0.580854           	0.730853                  	0.345294
CYP24A1      	83                      	1                        	1                     	20.5275            	0.00790623         	2.72451            	1.1321             	0.49334                   	0.688164
MFAP1        	86                      	1                        	1                     	18.4607            	0.0133889          	2.52736            	-0.228389          	0.884407                  	-0.145832
MBD5         	90                      	4                        	4                     	9.56169            	0.0144442          	2.49605            	0.362862           	0.818813                  	0.229766
SLA          	89                      	1                        	1                     	16.0687            	0.0380065          	2.10727            	0.548345           	0.73386                   	0.3411
THRB         	90                      	2                        	2                     	10.2182            	0.0617212          	1.89271            	0.796836           	0.617967                  	0.500528
sort: write failed: standard output: Broken pipe
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<h3 id="Variable-thresholds-test-for-rare-variants-(VT)">Variable thresholds test for rare variants (VT)<a class="anchor-link" href="#Variable-thresholds-test-for-rare-variants-(VT)"></a></h3><p>The variable thresholds (VT) method will carry out multiple testing in the same gene region using groups of variants based on observed variant allele frequencies. This test will maximize over statistics thus obtain a final test statistic, and calculate the empirical p-value so that multiple comparisons are adjusted for correctly.</p>
<p>We will use adaptive permutation to obtain empirical p-values. Therefore, to avoid performing too large number of permutations we use a cutoff to limit the number of permutations when the p-value is greater than 0.0005, e.g. not all 100,000 permutations are performed. Generally, even more permutations are used but we limit it to 100,000 to save time for this exercise.</p>
<p>The command using variable thresholds method on our data is:</p>

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      class="sos-source" name="Bash">vtools associate rare_ceu BMI --covariate SEX --samples "RACE=1" -m "VariableThresholdsQt --alternative 2 -p 100000 --adaptive 0.0005" \
    -g refGene.name2 -j1 --to_db EA_RV > EA_RV_VT.asso.res</textarea>
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<pre>INFO: 90 samples are selected by condition: (RACE=1)
INFO: 404 groups are found
Loading genotypes: 100% [===============================] 90 173.9/s in 00:00:00
Testing for association: 100% [======================] 404/<span class="ansi-red-intense-fg ansi-bold">13</span> 82.9/s in 00:00:04
INFO: Association tests on 404 groups have completed. 13 failed.
INFO: Using annotation DB EA_RV as EA_RV in project VATDemo.
INFO: Annotation database used to record results of association tests. Created on Fri, 06 Jul 2018 16:05:00
INFO: 404 out of 23269 refGene.refGene.name2 are annotated through annotation database EA_RV
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<p>To view test that failed,</p>

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<pre>2018-07-06 11:06:20,496: DEBUG: An ERROR has occurred in process 0 while processing &#39;BCL2L15&#39;: No variant found in genotype data for &#39;BCL2L15&#39;.
2018-07-06 11:06:20,851: DEBUG: An ERROR has occurred in process 0 while processing &#39;CDHR5&#39;: No variant found in genotype data for &#39;CDHR5&#39;.
2018-07-06 11:06:20,901: DEBUG: An ERROR has occurred in process 0 while processing &#39;CERS3&#39;: No variant found in genotype data for &#39;CERS3&#39;.
2018-07-06 11:06:21,062: DEBUG: An ERROR has occurred in process 0 while processing &#39;CTSW&#39;: No variant found in genotype data for &#39;CTSW&#39;.
2018-07-06 11:06:22,081: DEBUG: An ERROR has occurred in process 0 while processing &#39;LOC100287722&#39;: No variant found in genotype data for &#39;LOC100287722&#39;.
2018-07-06 11:06:22,485: DEBUG: An ERROR has occurred in process 0 while processing &#39;NOM1&#39;: Sample size too small (1) to be analyzed for &#39;NOM1&#39;.
2018-07-06 11:06:22,617: DEBUG: An ERROR has occurred in process 0 while processing &#39;OR10J1&#39;: No variant found in genotype data for &#39;OR10J1&#39;.
2018-07-06 11:06:23,321: DEBUG: An ERROR has occurred in process 0 while processing &#39;PRG3&#39;: No variant found in genotype data for &#39;PRG3&#39;.
2018-07-06 11:06:24,130: DEBUG: An ERROR has occurred in process 0 while processing &#39;SULT1A1&#39;: No variant found in genotype data for &#39;SULT1A1&#39;.
2018-07-06 11:06:24,318: DEBUG: An ERROR has occurred in process 0 while processing &#39;TMCC1&#39;: No variant found in genotype data for &#39;TMCC1&#39;.
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<p>To view results,</p>

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<pre>refgene_name2	sample_size_VTQt	num_variants_VTQt	total_mac_VTQt	beta_x_VTQt	pvalue_VTQt	std_error_VTQt	num_permutations_VTQt	MAF_threshold_VTQt
AATF         	89              	3                	3             	4.06571    	0.405594   	4.50659       	1000                 	0.00561798
ABCB9        	58              	1                	1             	4.29374    	0.659341   	7.16459       	1000                 	0.00862069
ABLIM3       	90              	2                	2             	-7.83832   	0.135864   	5.4353        	1000                 	0.00555556
ACCN3        	56              	1                	1             	9.84035    	0.171828   	7.06708       	1000                 	0.00892857
ACHE         	76              	1                	1             	1.51292    	0.799201   	7.50048       	1000                 	0.00657895
ACTL8        	81              	2                	2             	-4.82112   	0.433566   	5.42058       	1000                 	0.00617284
ADAM29       	88              	1                	1             	-6.52372   	0.4995     	7.64897       	1000                 	0.00568182
ADAMTS4      	69              	1                	1             	0.171944   	0.935065   	7.28058       	1000                 	0.00724638
AHNAK        	89              	4                	4             	-1.18887   	0.761239   	3.91307       	1000                 	0.00561798
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<p>Sort and output the lowest p-values using the command:</p>

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<pre>refgene_name2	sample_size_VTQt	num_variants_VTQt	total_mac_VTQt	beta_x_VTQt	pvalue_VTQt	std_error_VTQt	num_permutations_VTQt	MAF_threshold_VTQt
SPP2         	90              	2                	2             	15.0031    	0.00999001 	5.5654        	1000                 	0.00555556
CRTAP        	77              	1                	1             	20.4367    	0.011988   	7.72247       	1000                 	0.00649351
CYP24A1      	83              	1                	1             	20.5275    	0.013986   	7.76257       	1000                 	0.0060241
CIDEA        	73              	1                	1             	20.294     	0.017982   	7.5195        	1000                 	0.00684932
NRG1         	87              	1                	1             	-11.5171   	0.017982   	7.99103       	1000                 	0.00574713
WNT16        	88              	1                	1             	20.703     	0.01998    	7.64807       	1000                 	0.00568182
FUCA2        	80              	1                	1             	-10.9701   	0.025974   	7.74197       	1000                 	0.00625
LRRC27       	79              	1                	1             	-11.6328   	0.031968   	7.62696       	1000                 	0.00632911
PDSS1        	55              	1                	1             	-11.7564   	0.033966   	7.79539       	1000                 	0.00909091
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<h3 id="Why-do-some-tests-fail?">Why do some tests fail?<a class="anchor-link" href="#Why-do-some-tests-fail?"></a></h3><p>Notice that <code>vtools associate</code> command will fail on some association test units. Instances of failure are printed to terminal in red and are recorded in the project log file. Most failures occur due to an association test unit having too few samples or number of variants (for gene based analysis). You should view these error messages after each association scan is complete, e.g., using the Linux command <code>grep -i error *.log</code> and make sure you are informed of why failures occur.</p>
<p>In the variable thresholds analysis above, gene TMCC1 failed the association test. If we look at this gene more closely we can see which variants are being analyzed by our test:</p>

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<pre>chr	pos      	ref	alt	CEU_mafGD10	numGD10	mut_type
3  	129546729	T  	C  	0.0        	339    	nonsynonymous SNV
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<p>After applying our QC filters we are left with one variant within the TMCC1 gene to analyze. Because the MAF for this variant is 0.0 there are no variants in the gene to analyze so that this gene is ignored. Note that all individuals are homozygous for the alternative allele for this variant site.</p>
<h3 id="QQ-and-Manhattan-plots-for-association-results">QQ and Manhattan plots for association results<a class="anchor-link" href="#QQ-and-Manhattan-plots-for-association-results"></a></h3><p>The vtools report plot association command generates QQ and Manhattan plots from output of vtools associate command. More details about vtools report plot association can be found at</p>
<p><a href="http://varianttools.sourceforge.net/VtoolsReport/PlotAssociation">http://varianttools.sourceforge.net/VtoolsReport/PlotAssociation</a></p>

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      class="sos-source" name="Bash">vtools_report plot_association qq -o QQRV -b --label_top 2 -f 6 < EA_RV.asso.res
vtools_report plot_association manhattan -o MHRV -b --label_top 5 --color Dark2 --chrom_prefix None -f 6 < EA_RV.asso.res</textarea>
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<pre>INFO: Reading from standard input ...
INFO: Processing 78K of input data ...
INFO: Generating graph(s) ...
Genomic inflation factor for method &#39;LinRegBurden&#39; is: 1.25185482052633
INFO: Complete!
INFO: Reading from standard input ...
INFO: Processing 78K of input data ...
INFO: Generating graph(s) ...
INFO: Complete!
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<img src="data:image/png;base64,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"
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<p>QQ plots aid in evaluating if there is systematic inflation of test statistics. A common cause of inflation is population structure or batch effects.  If you observe significant inflation of test you may consider including MDS components in the association test model.</p>
<h3 id="MDS-analysis-and-PC-adjustment">MDS analysis and PC adjustment<a class="anchor-link" href="#MDS-analysis-and-PC-adjustment"></a></h3><p>This pipeline needs <a href="http://zzz.bwh.harvard.edu/plink/dist/plink-1.07-x86_64.zip">PLINK 1.07</a>
and <a href="http://people.virginia.edu/~wc9c/KING/executables/Linux-king214.tar.gz">KING</a>.</p>

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      class="sos-source" name="Bash">export PATH=/home/gaow/tmp/29-Jun-2018:$PATH
vtools execute KING</textarea>
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<pre>INFO: Executing <span class="ansi-green-fg">KING.king_0</span>: Load specified snapshot if a snapshot is specified. Otherwise use the existing project.
INFO: Executing <span class="ansi-green-fg">KING.king_10</span>: Check the existence of KING and PLINK command.
INFO: Command king is located.
INFO: Command plink is located.
INFO: Executing <span class="ansi-green-fg">KING.king_20</span>: Write selected variant and samples in tped format
INFO: Running <span class="ansi-green-fg">vtools export variant --format tped --samples &#34;1&#34; | awk &#39;{$2=$1&#34;_&#34;$4;$3=0;print $0}&#39; &gt; /data/ismb-2018/data/.vtools_cache/KING.tped</span>
INFO: Executing <span class="ansi-green-fg">KING.king_21</span>: Rename tfam file to match tped file
INFO: Running <span class="ansi-green-fg">mv variant.tfam /data/ismb-2018/data/.vtools_cache/KING.tfam</span>
INFO: Executing <span class="ansi-green-fg">KING.king_30</span>: Calculate LD pruning candidate list with a cutoff of R^2=0.5
INFO: Running <span class="ansi-green-fg">plink --noweb --tped KING.tped --tfam KING.tfam --indep-pairwise 50 5 0.5 --allow-no-sex --out KING.LD.50</span> under /data/ismb-2018/data/.vtools_cache
INFO: Executing <span class="ansi-green-fg">KING.king_31</span>: LD pruning from pre-calculated list
INFO: Running <span class="ansi-green-fg">plink --noweb --tped KING.tped --tfam KING.tfam --extract KING.LD.50.prune.in --no-parents --no-sex --no-pheno --maf 0.01 --make-bed --out KING</span> under /data/ismb-2018/data/.vtools_cache
INFO: Executing <span class="ansi-green-fg">KING.king_41</span>: Global ancestry inference
INFO: Running <span class="ansi-green-fg">king -b KING.bed --mds --ibs --prefix KING-</span> under /data/ismb-2018/data/.vtools_cache
INFO: Executing <span class="ansi-green-fg">KING.king_42</span>: Kinship inference
INFO: Running <span class="ansi-green-fg">king -b KING.bed --kinship --related --degree 3 --prefix KING</span> under /data/ismb-2018/data/.vtools_cache
INFO: Executing <span class="ansi-green-fg">KING.king_51</span>: Extract MDS result for vtools phenotype import
INFO: Running <span class="ansi-green-fg">cut KING-pc.ped -f 2,`seq -s, 7 $((6+5))` -d &#34; &#34; | sed -e &#34;s/ /\\t/g&#34; | sed 1i&#34;sample_name`seq -s, 1 5 | awk -F, &#39;{if (NF&gt;20) NF=20; for (i=1; i&lt;=NF; ++i) printf(&#34;\\t%s&#34;, &#34;KING_MDS&#34;$i)}&#39;`&#34; &gt; KING-mds.vtools.txt</span> under /data/ismb-2018/data/.vtools_cache
INFO: Executing <span class="ansi-green-fg">KING.king_52</span>: Import phenotype from global ancestry analysis
INFO: Running <span class="ansi-green-fg">vtools phenotype --from_file /data/ismb-2018/data/.vtools_cache/KING-mds.vtools.txt</span>
INFO: Adding phenotype KING_MDS1 of type FLOAT
INFO: Adding phenotype KING_MDS2 of type FLOAT
INFO: Adding phenotype KING_MDS3 of type FLOAT
INFO: Adding phenotype KING_MDS4 of type FLOAT
INFO: Adding phenotype KING_MDS5 of type FLOAT
INFO: 5 field (5 new, 0 existing) phenotypes of 196 samples are updated.
INFO: Executing <span class="ansi-green-fg">KING.king_61</span>: Save global ancestry inference result to plot
INFO: Running <span class="ansi-green-fg">vtools_report plot_pheno_fields KING_MDS1 KING_MDS2 --samples &#34;1&#34; --dot KING.mds.pdf --discrete_color Accent</span>
INFO: Executing <span class="ansi-green-fg">KING.king_62</span>: Save kinship analysis result to text file
INFO: Running <span class="ansi-green-fg">cat /data/ismb-2018/data/.vtools_cache/KING.kin0 | cut -f 2,4,6,7,8 | awk &#39;{ if ($5&gt;0.0442) print $0}&#39; | awk &#39;{if ($5&gt;0.354) $6=&#34;MZ&#34;; if ($5&gt;=0.177 &amp;&amp; $5&lt;=0.354) $6=&#34;1st-degree&#34;; if ($5&gt;=0.0884 &amp;&amp; $5&lt;=0.177) $6=&#34;2nd-degree&#34;; if ($5&gt;=0.0442 &amp;&amp; $5&lt;=0.0884) $6=&#34;3rd-degree&#34;; if ($5==&#34;Kinship&#34;) $6=&#34;Relationship&#34;; print $0}&#39; &gt; KING.RelatedIndividuals.txt</span>
INFO: Execution of pipeline KING.king is successful with output KING.RelatedIndividuals.txt
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<img 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"
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<p>You should not arbitrarily include MDS (or PCA) components in the analysis.  Instead put in each MDS component and examine the lambda value, i.e. include MDS component 1 them MDS components 1 and 2, etc. Visualization of the QQ plot is also useful to determine if population substructure/admixture is controlled.</p>
<h2 id="2.6--Association-analysis-of-YRI-samples">2.6  Association analysis of YRI samples<a class="anchor-link" href="#2.6--Association-analysis-of-YRI-samples"></a></h2><p>Procedures for YRI sample association analysis is the same as for CEU samples as previously has been described, thus is left as an extra exercise for you to work on your own. Commands to perform analysis for YRI are found below:</p>

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      class="sos-source" name="Bash">vtools associate rare_ceu BMI --covariate SEX KING_MDS1 KING_MDS2 -m "LinRegBurden --name RVMDS2 --alternative 2" -g refGene.name2 -j1 --to_db EA_RV > EA_RV_MDS2.asso.res</textarea>
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<pre><span class="ansi-magenta-intense-fg">WARNING</span>: <span class="ansi-magenta-intense-fg">Sample NA12889 is ignored due to missing value for phenotype KING_MDS1</span>
<span class="ansi-magenta-intense-fg">WARNING</span>: <span class="ansi-magenta-intense-fg">Sample NA12889 is ignored due to missing value for phenotype KING_MDS2</span>
<span class="ansi-magenta-intense-fg">WARNING</span>: <span class="ansi-magenta-intense-fg">Sample NA18504 is ignored due to missing value for phenotype KING_MDS1</span>
<span class="ansi-magenta-intense-fg">WARNING</span>: <span class="ansi-magenta-intense-fg">Sample NA18504 is ignored due to missing value for phenotype KING_MDS2</span>
<span class="ansi-magenta-intense-fg">WARNING</span>: <span class="ansi-magenta-intense-fg">Sample NA18516 is ignored due to missing value for phenotype KING_MDS1</span>
<span class="ansi-magenta-intense-fg">WARNING</span>: <span class="ansi-magenta-intense-fg">Sample NA18516 is ignored due to missing value for phenotype KING_MDS2</span>
<span class="ansi-magenta-intense-fg">WARNING</span>: <span class="ansi-magenta-intense-fg">Sample NA18522 is ignored due to missing value for phenotype KING_MDS1</span>
<span class="ansi-magenta-intense-fg">WARNING</span>: <span class="ansi-magenta-intense-fg">Sample NA18522 is ignored due to missing value for phenotype KING_MDS2</span>
<span class="ansi-magenta-intense-fg">WARNING</span>: <span class="ansi-magenta-intense-fg">Sample NA18870 is ignored due to missing value for phenotype KING_MDS1</span>
<span class="ansi-magenta-intense-fg">WARNING</span>: <span class="ansi-magenta-intense-fg">Sample NA18870 is ignored due to missing value for phenotype KING_MDS2</span>
<span class="ansi-magenta-intense-fg">WARNING</span>: <span class="ansi-magenta-intense-fg">Sample NA18871 is ignored due to missing value for phenotype KING_MDS1</span>
<span class="ansi-magenta-intense-fg">WARNING</span>: <span class="ansi-magenta-intense-fg">Sample NA18871 is ignored due to missing value for phenotype KING_MDS2</span>
INFO: 196 samples are found
INFO: 404 groups are found
Loading genotypes: 100% [===============================] 196 93.2/s in 00:00:02
Testing for association: 100% [======================] 404/<span class="ansi-red-intense-fg ansi-bold">5</span> 347.6/s in 00:00:01
INFO: Association tests on 404 groups have completed. 5 failed.
INFO: Using annotation DB EA_RV as EA_RV in project VATDemo.
INFO: Annotation database used to record results of association tests. Created on Fri, 06 Jul 2018 16:05:00
INFO: 404 out of 23269 refGene.refGene.name2 are annotated through annotation database EA_RV
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      class="sos-source" name="Bash">vtools_report plot_association qq -o QQRV_MDS2 -b --label_top 2 -f 6 < EA_RV_MDS2.asso.res</textarea>
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<pre>INFO: Reading from standard input ...
INFO: Processing 99K of input data ...
INFO: Generating graph(s) ...
Genomic inflation factor for method &#39;RVMDS2&#39; is: 1.2732420092267
INFO: Complete!
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      class="sos-source" name="Bash">vtools select variant "YRI_mafGD10>=0.05" --samples "RACE=0" -t common_yri </textarea>
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<pre>INFO: 112 samples are selected by condition: RACE=0
Collecting sample variants: 100% [======================] 112 1.5K/s in 00:00:00
Running: 10 1.4K/s in 00:00:00
INFO: 1984 variants selected.
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<pre>INFO: 112 samples are selected by condition: RACE=0
Collecting sample variants: 100% [======================] 112 1.7K/s in 00:00:00
Running: 9 1.3K/s in 00:00:00
INFO: 746 variants selected.
</pre>
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   <textarea rows="1"
      class="sos-source" name="Bash">vtools associate common_yri BMI --covariate SEX --samples "RACE=0" -m "LinRegBurden --alternative 2" -j1 --to_db YA_CV > YA_CV.asso.res</textarea>
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<pre>INFO: 112 samples are selected by condition: (RACE=0)
INFO: 1984 groups are found
Loading genotypes: 100% [==============================] 112 131.5/s in 00:00:00
Testing for association: 100% [===================] 1,984/<span class="ansi-red-intense-fg ansi-bold">12</span> 568.0/s in 00:00:03
INFO: Association tests on 1984 groups have completed. 12 failed.
INFO: Using annotation DB YA_CV as YA_CV in project VATDemo.
INFO: Annotation database used to record results of association tests. Created on Fri, 06 Jul 2018 16:12:39
INFO: 1984 out of 6986 variant.chr, variant.pos are annotated through annotation database YA_CV
</pre>
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   <textarea rows="1"
      class="sos-source" name="Bash">vtools associate rare_yri BMI --covariate SEX --samples "RACE=0" -m "LinRegBurden --alternative 2" -g refGene.name2 -j1 --to_db YA_RV > YA_RV.asso.res </textarea>
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<pre>INFO: 112 samples are selected by condition: (RACE=0)
INFO: 419 groups are found
Loading genotypes: 100% [==============================] 112 278.4/s in 00:00:00
Testing for association: 100% [=====================] 419/<span class="ansi-red-intense-fg ansi-bold">11</span> 519.6/s in 00:00:00
INFO: Association tests on 419 groups have completed. 11 failed.
INFO: Using annotation DB YA_RV as YA_RV in project VATDemo.
INFO: Annotation database used to record results of association tests. Created on Fri, 06 Jul 2018 16:12:46
INFO: 419 out of 23269 refGene.refGene.name2 are annotated through annotation database YA_RV
</pre>
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   <textarea rows="2"
      class="sos-source" name="Bash">vtools associate rare_yri BMI --covariate SEX --samples "RACE=0" -m "VariableThresholdsQt --alternative 2 -p 100000 --adaptive 0.0005" \
    -g refGene.name2 -j1 --to_db YA_RV > YA_RV_VT.asso.res</textarea>
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<pre>INFO: 112 samples are selected by condition: (RACE=0)
INFO: 419 groups are found
Loading genotypes: 100% [===============================] 112 64.6/s in 00:00:01
Testing for association: 100% [======================] 419/<span class="ansi-red-intense-fg ansi-bold">11</span> 68.2/s in 00:00:06
INFO: Association tests on 419 groups have completed. 11 failed.
INFO: Using annotation DB YA_RV as YA_RV in project VATDemo.
INFO: Annotation database used to record results of association tests. Created on Fri, 06 Jul 2018 16:12:46
INFO: 419 out of 23269 refGene.refGene.name2 are annotated through annotation database YA_RV
</pre>
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<h2 id="2.7--Meta-analysis">2.7  Meta-analysis<a class="anchor-link" href="#2.7--Meta-analysis"></a></h2><p>Here we demonstrate the application of meta-analysis to combine association results from the two populations via <code>vtools report meta_analysis</code>. More details about <code>vtools report meta_analysis</code> command can be found at</p>
<p><a href="http://varianttools.sourceforge.net/VtoolsReport/MetaAnalysis">http://varianttools.sourceforge.net/VtoolsReport/MetaAnalysis</a></p>
<p>The input to this command are the association results files generated from previous steps, for example:</p>

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      class="sos-source" name="Bash">vtools_report meta_analysis EA_RV_VT.asso.res YA_RV_VT.asso.res --beta 5 --pval 6 --se 7 -n 2 --link 1 > META_RV_VT.asso.res</textarea>
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<p>To view the results,</p>

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      class="sos-source" name="Bash">cut -f1,3 META_RV_VT.asso.res | sort -g -k2 | head</textarea>
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<pre>refgene_name2	pvalue_meta
RREB1	1.497E-02
TTC26	2.743E-02
MBD5	3.152E-02
RAD51AP1	3.582E-02
SHKBP1	4.222E-02
CYP24A1	4.336E-02
VLDLR	4.664E-02
PPIG	4.731E-02
PLXDC1	5.296E-02
</pre>
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<p>Note that for genes that only appears in one study but not the other, or only have a valid p-value in one study but not the other, will be ignored from meta-analysis.</p>
<h2 id="2.8--Summary">2.8  Summary<a class="anchor-link" href="#2.8--Summary"></a></h2><p>Analyzing variants with VAT is much like any other analysis software with a general workflow of:</p>
<ul>
<li>Variant level cleaning</li>
<li>Sample genotype cleaning</li>
<li>Variant annotation and phenotype information processing</li>
<li>Sample/variant selection</li>
<li>Association analysis</li>
<li>Interpreting the findings</li>
</ul>
<p>The data cleaning and filtering conditions within this exercise should be considered as general guidelines. Your data may allow you to be laxer with certain criteria or force you to be more stringent with others.</p>

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<h1 id="References">References<a class="anchor-link" href="#References"></a></h1><p>[1]Wang, G.T., Peng, B., and Leal, S.M. (2014). Variant Association Tools for Quality Control and Analysis of Large-Scale Sequence and Genotyping Array Data. Am. J. Hum. Genet. 94, 770783</p>
<p>[2]Li B, Leal SM. Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am J Hum Genet 2008 83:311-21</p>
<p>[3]Auer PL, Wang G, Leal SM. Testing for rare variant associations in the presence of missing data. Genet Epidemiol 2013 37:529-38</p>
<p>[4]Liu DJ, Leal SM. A novel adaptive method for the analysis of next-generation sequencing data to detect com-plex trait associations with rare variants due to gene main effects and interactions. PLoS Genet 2010 6:e1001156</p>
<p>[5]Madsen BE, Browning SR. A groupwise association test for rare mutations using a weighted sum statistic. PLoS Genet 2009 5:e1000384</p>
<p>[6]Price AL, Kryukov GV, de Bakker PI, Purcell SM, Staples J, Wei LJ, Sunyaev SR. Pooled association tests for rare variants in exon-resequencing studies. Am J Hum Genet 20010 86:832-8</p>
<p>[7]Wu MC, Lee S, Cai T, Li Y, Boehnke M, Lin X. Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet 2011 89:82-93</p>
<p>[8]Lucas FAS, Wang G, Scheet P, Peng B. Integrated annotation and analysis of genetic variants from next-generation sequencing studies with variant tools. Bioinformatics 2012 28:421-2</p>
<p>[9]Wang K, Li M, Hakonarson H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 2010 38:e164</p>
<p>[10]Manichaikul A, Mychaleckyj JC, Rich SS, Daly K, Sale M, Chen WM. Robust relationship inference in genome-wide association studies. Bioinformatics 2010 26(22):2867-2873</p>
<p>[11]Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, Maller J, Sklar P, de Bakker PIW, Daly MJ &amp; Sham PC. PLINK: a toolset for whole-genome association and population-based linkage analysis. Am J Hum Genet, 2007 81:559-75</p>

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    } else {
      // this is SoS mode
      base_mode = CodeMirror.getMode(conf, sosPythonConf);
      overlay_mode = markExpr(base_mode);
      return {
        startState: function() {
          return {
            sos_state: null,
            base_state: CodeMirror.startState(base_mode),
            overlay_state: CodeMirror.startState(overlay_mode),
            inner_mode: null,
            inner_state: null,
            // for overlay
            basePos: 0,
            baseCur: null,
            overlayPos: 0,
            overlayCur: null,
            streamSeen: null
          };
        },

        copyState: function(state) {
          return {
            sos_state: state.sos_state,
            base_state: CodeMirror.copyState(base_mode, state.base_state),
            overlay_state: CodeMirror.copyState(overlay_mode, state.overlay_state),
            inner_mode: state.inner_mode,
            inner_state: state.inner_mode && CodeMirror.copyState(state.inner_mode, state.inner_state),
            // for overlay
            basePos: state.basePos,
            baseCur: null,
            overlayPos: state.overlayPos,
            overlayCur: null
          };
        },

        token: function(stream, state) {
          if (stream.sol()) {
            let sl = stream.peek();
            if (sl == '[') {
              // header, move to the end
              if (stream.match(/^\[.*\]$/, false)) {
                // if there is no :, the easy case
                if (stream.match(/^\[[^:]*\]$/)) {
                  // reset state
                  state.sos_state = null;
                  state.inner_mode = null;
                  return "header line-section-header";
                } else {
                  // match up to :
                  stream.match(/^\[[^:]*:/);
                  state.sos_state = 'header_option';
                  return "header line-section-header";
                }
              }
            } else if (sl == '!') {
              stream.eatWhile(/\S/);
              return "meta";
            } else if (sl == '#') {
              stream.skipToEnd();
              return "comment";
            } else if (sl == '%') {
              stream.eatWhile(/\S/);
              return "meta";
            } else if (state.sos_state && state.sos_state.startsWith('entering')) {
              // the second parameter is starting column
              let mode = findMode(state.sos_state.slice(9).toLowerCase());
              state.inner_mode = CodeMirror.getMode(conf, mode);
              state.inner_state = CodeMirror.startState(state.inner_mode, stream.indentation());
              state.sos_state = null;
            }
            for (var i = 0; i < sosDirectives.length; i++) {
              if (stream.match(sosDirectives[i])) {
                // the rest of the lines will be processed as Python code
                state.sos_state = 'directive_option'
                return "keyword strong";
              }
            }
            for (var i = 0; i < sosActions.length; i++) {
              if (stream.match(sosActions[i])) {
                // switch to submode?
                if (stream.eol()) {
                  // really
                  let mode = findMode(stream.current().slice(0, -1).toLowerCase());
                  if (mode) {
                    state.sos_state = "entering " + stream.current().slice(0, -1);
                  } else {
                    state.sos_state = 'unknown_language';
                  }
                } else {
                  state.sos_state = 'start ' + stream.current().slice(0, -1);
                }
                state.overlay_state.sigil = null;
                return "builtin strong";
              }
            }
            // if unknown action
            if (stream.match(/\w+:/)) {
              state.overlay_state.sigil = null;
              state.sos_state = 'start ' + stream.current().slice(0, -1);
              return "builtin strong";
            }
          } else if (state.sos_state == 'header_option') {
            // stuff after :
            if (stream.peek() == ']') {
              // move next
              stream.next();
              // ] is the last char
              if (stream.eol()) {
                state.sos_state = null;
                state.inner_mode = null;
                return "header line-section-header";
              } else {
                stream.backUp(1);
                let it = base_mode.token(stream, state.base_state);
                return it ? it + ' sos-option' : null;
              }
            } else {
              let it = base_mode.token(stream, state.base_state);
              return it ? it + ' sos-option' : null;
            }
          } else if (state.sos_state == 'directive_option') {
            // stuff after input:, R: etc
            if (stream.peek() == ',') {
              // move next
              stream.next();
              // , is the last char, continue option line
              if (stream.eol()) {
                stream.backUp(1);
                let it = base_mode.token(stream, state.base_state);
                return it ? it + ' sos-option' : null;
              }
              stream.backUp(1);
            } else if (stream.eol()) {
              // end of line stops option mode
              state.sos_state = null;
              state.inner_mode = null;
            }
            let it = base_mode.token(stream, state.base_state);
            return it ? it + ' sos-option' : null;
          } else if (state.sos_state && state.sos_state.startsWith("start ")) {
            // try to understand option expand=
            if (stream.match(/expand\s*=\s*True/, false)) {
              // highlight {}
              state.overlay_state.sigil = {
                'left': '{',
                'right': '}'
              }
            } else {
              let found = stream.match(/expand\s*=\s*"(\S+) (\S+)"/, false);
              if (!found)
                found = stream.match(/expand\s*=\s*'(\S+) (\S+)'/, false);
              if (found) {
                state.overlay_state.sigil = {
                  'left': found[1],
                  'right': found[2]
                }
              }
            }
            let token = base_mode.token(stream, state.base_state);
            // if it is end of line, ending the starting switch mode
            if (stream.eol() && stream.peek() !== ',') {
              // really
              let mode = findMode(state.sos_state.slice(6).toLowerCase());
              if (mode) {
                state.sos_state = "entering " + state.sos_state.slice(6);
              } else {
                state.sos_state = 'unknown_language';
              }
            }
            return token + ' sos-option';
          }
          // can be start of line but not special
          if (state.sos_state == 'unknown_language') {
            // we still handle {} in no man unknown_language
            if (state.overlay_state.sigil) {
              return overlay_mode.token(stream, state.overlay_state);
            } else {
              stream.skipToEnd();
              return null;
            }
          } else if (state.inner_mode) {
            let it = 'sos_script ';
            if (!state.overlay_state.sigil) {
              let st = state.inner_mode.token(stream, state.inner_state);
              return st ? it + st : null;
            } else {
              // overlay mode, more complicated
              if (stream != state.streamSeen ||
                Math.min(state.basePos, state.overlayPos) < stream.start) {
                state.streamSeen = stream;
                state.basePos = state.overlayPos = stream.start;
              }

              if (stream.start == state.basePos) {
                state.baseCur = state.inner_mode.token(stream, state.inner_state);
                state.basePos = stream.pos;
              }
              if (stream.start == state.overlayPos) {
                stream.pos = stream.start;
                state.overlayCur = overlay_mode.token(stream, state.overlay_state);
                state.overlayPos = stream.pos;
              }
              stream.pos = Math.min(state.basePos, state.overlayPos);
              // state.overlay.combineTokens always takes precedence over combine,
              // unless set to null
              return (state.overlayCur ? state.overlayCur : state.baseCur) + " sos-script";
            }
          } else {
            return base_mode.token(stream, state.base_state);
          }
        },

        indent: function(state, textAfter) {
          // inner indent
          if (state.inner_mode) {
            if (!state.inner_mode.indent) return CodeMirror.Pass;
            return state.inner_mode.indent(state.inner_mode, textAfter) + 2;
          } else {
            return base_mode.indent(state.base_state, textAfter);
          }
        },

        innerMode: function(state) {
          return state.inner_mode ? null : {
            state: state.base_state,
            mode: base_mode
          };
        },

        lineComment: "#",
        fold: "indent",
        electricInput: /^\s*[\}\]\)]$/,
      };
    };
  }, "python");

  CodeMirror.defineMIME("text/x-sos", "sos");
});
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