Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

How to integrate lods from different markers and in different families in the same gene? #39

Open
changebio opened this issue Mar 2, 2022 · 1 comment

Comments

@changebio
Copy link
Contributor

elif fam not in lods[theta] or lod > lods[theta][fam]:

Based on the code, it uses max lod in markers and add all lods among families.
lod = log10(P(theta))-log10(P(0.5)), theta is seq(0,0.45,0.05)
About integrating among families.
I think it is fine if the max lods are bigger than 0, we add them up.
If the max lods are less than 0, what is the meaning? should we set them to 0?

@gaow
Copy link
Owner

gaow commented Mar 2, 2022

LOD is Log odds and can certainly be smaller than 0: it means the odds is smaller than 1. We should keep them as is.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

2 participants