diff --git a/src/library_dylink.js b/src/library_dylink.js
index f9f088d5e379..da269a48b9fc 100644
--- a/src/library_dylink.js
+++ b/src/library_dylink.js
@@ -526,9 +526,22 @@ var LibraryDylink = {
     return customSection;
   },
 
+#if DYNCALLS || !WASM_BIGINT
+  $registerDynCallSymbols: (exports) => {
+    for (var [sym, exp] of Object.entries(exports)) {
+      if (sym.startsWith('dynCall_') && !Module.hasOwnProperty(sym)) {
+        Module[sym] = exp;
+      }
+    }
+  },
+#endif
+
   // Module.symbols <- libModule.symbols (flags.global handler)
   $mergeLibSymbols__deps: ['$isSymbolDefined'],
   $mergeLibSymbols: (exports, libName) => {
+#if DYNCALLS || !WASM_BIGINT
+    registerDynCallSymbols(exports);
+#endif
     // add symbols into global namespace TODO: weak linking etc.
     for (var [sym, exp] of Object.entries(exports)) {
 #if ASSERTIONS == 2
@@ -571,10 +584,6 @@ var LibraryDylink = {
         setImport('main')
       }
 #endif
-
-      if (sym.startsWith('dynCall_') && !Module.hasOwnProperty(sym)) {
-        Module[sym] = exp;
-      }
     }
   },
 
@@ -938,6 +947,9 @@ var LibraryDylink = {
                               '$asyncLoad',
 #if FILESYSTEM
                               '$preloadedWasm',
+#endif
+#if DYNCALLS || !WASM_BIGINT
+                              '$registerDynCallSymbols',
 #endif
   ],
   $loadDynamicLibrary__docs: `
@@ -963,6 +975,9 @@ var LibraryDylink = {
         if (localScope) {
           Object.assign(localScope, dso.exports);
         }
+#if DYNCALLS || !WASM_BIGINT
+        registerDynCallSymbols(dso.exports);
+#endif
       } else if (!dso.global) {
         // The library was previously loaded only locally but not
         // we have a request with global=true.
@@ -1046,6 +1061,9 @@ var LibraryDylink = {
         mergeLibSymbols(exports, libName);
       } else if (localScope) {
         Object.assign(localScope, exports);
+#if DYNCALLS || !WASM_BIGINT
+        registerDynCallSymbols(exports);
+#endif
       }
       dso.exports = exports;
     }
diff --git a/test/other/codesize/test_codesize_hello_dylink.gzsize b/test/other/codesize/test_codesize_hello_dylink.gzsize
index 190e05fb52d2..b7f6d0eb72bf 100644
--- a/test/other/codesize/test_codesize_hello_dylink.gzsize
+++ b/test/other/codesize/test_codesize_hello_dylink.gzsize
@@ -1 +1 @@
-6285
+6307
diff --git a/test/other/codesize/test_codesize_hello_dylink.jssize b/test/other/codesize/test_codesize_hello_dylink.jssize
index 61d1af505618..f238adcd67c2 100644
--- a/test/other/codesize/test_codesize_hello_dylink.jssize
+++ b/test/other/codesize/test_codesize_hello_dylink.jssize
@@ -1 +1 @@
-13820
+13896
diff --git a/test/test_core.py b/test/test_core.py
index 846725e7a4ff..bb868f07dbf0 100644
--- a/test/test_core.py
+++ b/test/test_core.py
@@ -4385,18 +4385,38 @@ def test_dylink_i64_c(self):
       EMSCRIPTEN_KEEPALIVE int64_t function_ret_64(int32_t i, int32_t j, int32_t k);
     ''', force_c=True)
 
+  @parameterized({
+    '': (False,),
+    'rtld_local': (True,),
+  })
   @needs_dylink
   @also_with_wasm_bigint
-  def test_dylink_i64_invoke(self):
+  def test_dylink_i64_invoke(self, rtld_local):
+    if rtld_local:
+      self.set_setting('NO_AUTOLOAD_DYLIBS')
+      self.emcc_args.append('-DUSE_DLOPEN')
     self.set_setting('DISABLE_EXCEPTION_CATCHING', 0)
     self.dylink_test(r'''\
+    #include <assert.h>
     #include <stdio.h>
     #include <stdint.h>
 
+    #if USE_DLOPEN
+    #include <dlfcn.h>
+    typedef int64_t (*sidey_t)(int64_t arg);
+    #else
     extern "C" int64_t sidey(int64_t arg);
+    #endif
 
     int main(int argc, char *argv[]) {
         int64_t temp = 42;
+    #if USE_DLOPEN
+        void* lib = dlopen("liblib.so", RTLD_LAZY);
+        assert(lib);
+        sidey_t sidey = (sidey_t)dlsym(lib, "sidey");
+        assert(sidey);
+    #endif
+
         printf("got %lld\n", sidey(temp));
         printf("got %lld\n", sidey(0));
         return 0;