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KP.3.1.1+S:D111N(83 seqs,>10 places) #2804

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xz-keg opened this issue Oct 13, 2024 · 8 comments
Open

KP.3.1.1+S:D111N(83 seqs,>10 places) #2804

xz-keg opened this issue Oct 13, 2024 · 8 comments

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@xz-keg
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xz-keg commented Oct 13, 2024

From sars-cov-2-variants/lineage-proposals#2108
KP.3.1.1+G21893A(S:D111N)

S:D111N is one of the newly-emerged beneficial mutations on KP.3.1.1 backbone. 16% global advantage on cov-spectrum.
image

https://cov-spectrum.org/explore/World/AllSamples/Past3M/variants?nextcladePangoLineage=KP.3.1.1*&aaMutations1=S%3AD111N&nextcladePangoLineage1=KP.3.1.1*&analysisMode=CompareToBaseline&
S:D111N is very convergent on KP.3.1.1, here I exclude lineages that clearly do not belong to the main branch, and keep those seqs placed under artifact, flip-flop, or other convergent mutations in the count.

GISAID query:G21893A, C12616T,A13121T, -24095, -1354,-29716,-13297,-16332,-25595,-9699,-6066,-4851,-11094,-6391,-27692,-27128,-21855,-25998,-6536,-6286 (may include more -s)
No. of seqs: 53(Australia 5 Brazil 2 Canada 3 Denmark 3 UK 7(England, Scotland, Wales) France 1 Germany 1 Ireland 2 Israel 1 Italy 2 South Korea 1 Spain 1 Sweden 1 USA 23(MD,MI,MN,NY,PA,SD,GBW from Greenland))

First: EPI_ISL_19462720, Spain, 2024-7-14
Latest: EPI_ISL_19465014, England, 2024-9-26

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@Mydtlwn
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Mydtlwn commented Oct 13, 2024

@corneliusroemer

@FedeGueli
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Query unchanged in comparison to the last update right? @xz-keg

@FedeGueli
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@corneliusroemer

When you will start designating i suggest if you have time to check S:D111N all over the tree it seems a new hotspot for convergence.

@xz-keg
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xz-keg commented Oct 13, 2024

Query unchanged in comparison to the last update right? @xz-keg

yeah but it will certainly add a lot of new -s in the future.

When number of seqs* number of -s>number of mutation spots, it will be unsafe to assume every - belongs to a separate branch.

@FedeGueli
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Thx @xz-keg

@xz-keg xz-keg changed the title KP.3.1.1+S:D111N(53 seqs,>10 places) KP.3.1.1+S:D111N(60 seqs,>10 places) Oct 18, 2024
@xz-keg
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xz-keg commented Oct 23, 2024

73 now, also in Slovakia.

@xz-keg xz-keg changed the title KP.3.1.1+S:D111N(60 seqs,>10 places) KP.3.1.1+S:D111N(73 seqs,>10 places) Oct 23, 2024
@FedeGueli
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10/73 in October , it is fast

@xz-keg xz-keg changed the title KP.3.1.1+S:D111N(73 seqs,>10 places) KP.3.1.1+S:D111N(83 seqs,>10 places) Oct 28, 2024
@Mydtlwn
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Mydtlwn commented Oct 29, 2024

@corneliusroemer

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