From 9972efd319b51be5266606dc1995ef1413c4385b Mon Sep 17 00:00:00 2001
From: Matthew Solomonson <ggmatt@gmail.com>
Date: Wed, 1 Nov 2023 11:27:20 -0400
Subject: [PATCH] Don't allow TTN API lookups by gene or transcript

---
 .../gnomad-v4-variant-queries.ts              | 49 +++++++++++--------
 1 file changed, 29 insertions(+), 20 deletions(-)

diff --git a/graphql-api/src/queries/variant-datasets/gnomad-v4-variant-queries.ts b/graphql-api/src/queries/variant-datasets/gnomad-v4-variant-queries.ts
index 26e2f02a3..982ab8bcb 100644
--- a/graphql-api/src/queries/variant-datasets/gnomad-v4-variant-queries.ts
+++ b/graphql-api/src/queries/variant-datasets/gnomad-v4-variant-queries.ts
@@ -170,9 +170,9 @@ const fetchVariantById = async (esClient: any, variantIdOrRsid: any, subset: any
       populations: variant.exome.freq[subset].ancestry_groups,
       faf95: hasExomeVariant &&
         variant.exome.faf95 && {
-          popmax_population: variant.exome.faf95.grpmax_gen_anc,
-          popmax: variant.exome.faf95.grpmax,
-        },
+        popmax_population: variant.exome.faf95.grpmax_gen_anc,
+        popmax: variant.exome.faf95.grpmax,
+      },
       quality_metrics: {
         // TODO: An older version of the data pipeline stored only adj quality metric histograms.
         // Maintain the same behavior by returning the adj version until the API schema is updated to allow
@@ -201,9 +201,9 @@ const fetchVariantById = async (esClient: any, variantIdOrRsid: any, subset: any
       populations: genome_ancestry_groups,
       faf95: hasGenomeVariant &&
         variant.genome.faf95 && {
-          popmax_population: variant.genome.faf95.grpmax_gen_anc,
-          popmax: variant.genome.faf95.grpmax,
-        },
+        popmax_population: variant.genome.faf95.grpmax_gen_anc,
+        popmax: variant.genome.faf95.grpmax,
+      },
       quality_metrics: {
         // TODO: An older version of the data pipeline stored only adj quality metric histograms.
         // Maintain the same behavior by returning the adj version until the API schema is updated to allow
@@ -270,23 +270,23 @@ const shapeVariantSummary = (subset: any, context: any) => {
       alt: variant.alleles[1],
       exome: hasExomeVariant
         ? {
-            ...omit(variant.exome, 'freq'), // Omit freq field to avoid caching extra copy of frequency information
-            ...variant.exome.freq[subset],
-            populations: variant.exome.freq[subset].ancestry_groups.filter(
-              (pop: any) => !(pop.id.includes('_') || pop.id === 'XX' || pop.id === 'XY')
-            ),
-            filters,
-          }
+          ...omit(variant.exome, 'freq'), // Omit freq field to avoid caching extra copy of frequency information
+          ...variant.exome.freq[subset],
+          populations: variant.exome.freq[subset].ancestry_groups.filter(
+            (pop: any) => !(pop.id.includes('_') || pop.id === 'XX' || pop.id === 'XY')
+          ),
+          filters,
+        }
         : null,
       genome: hasGenomeVariant
         ? {
-            ...omit(variant.genome, 'freq'), // Omit freq field to avoid caching extra copy of frequency information
-            ...variant.genome.freq[subset],
-            populations: variant.genome.freq[subset].ancestry_groups.filter(
-              (pop: any) => !(pop.id.includes('_') || pop.id === 'XX' || pop.id === 'XY')
-            ),
-            filters,
-          }
+          ...omit(variant.genome, 'freq'), // Omit freq field to avoid caching extra copy of frequency information
+          ...variant.genome.freq[subset],
+          populations: variant.genome.freq[subset].ancestry_groups.filter(
+            (pop: any) => !(pop.id.includes('_') || pop.id === 'XX' || pop.id === 'XY')
+          ),
+          filters,
+        }
         : null,
       flags,
       transcript_consequence: transcriptConsequence,
@@ -311,6 +311,10 @@ const fetchVariantsByGene = async (esClient: any, gene: any, _subset: any) => {
   const exomeSubset = 'all'
   const genomeSubset = 'all'
 
+  if (gene.symbol === "TTN") {
+    throw new UserVisibleError("TTN coming soon to gnomAD v4")
+  }
+
   try {
     const filteredRegions = gene.exons.filter((exon: any) => exon.feature_type === 'CDS')
     const sortedRegions = filteredRegions.sort((r1: any, r2: any) => r1.xstart - r2.xstart)
@@ -439,6 +443,11 @@ const fetchVariantsByTranscript = async (esClient: any, transcript: any, _subset
   const exomeSubset = 'all'
   const genomeSubset = 'all'
 
+
+  if (transcript.gene.symbol === "TTN") {
+    throw new UserVisibleError("TTN coming soon to gnomAD v4")
+  }
+
   const filteredRegions = transcript.exons.filter((exon: any) => exon.feature_type === 'CDS')
   const sortedRegions = filteredRegions.sort((r1: any, r2: any) => r1.xstart - r2.xstart)
   const padding = 75