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Allowing more than one enzyme as cleavage agent #469

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cecilia992 opened this issue Jan 7, 2025 · 2 comments
Open

Allowing more than one enzyme as cleavage agent #469

cecilia992 opened this issue Jan 7, 2025 · 2 comments
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enhancement New feature or request

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@cecilia992
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Description of feature

It would be useful if more than one enzyme could be selected rather than just one. I understand that not all tools allow multiple enzymes digestion but it would be good to have this option even if we are then forced to use only one tool, such as comet.
@cecilia992 cecilia992 added the enhancement New feature or request label Jan 7, 2025
@ypriverol
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We have started to support more enzymes in the workflow in more tools. Can you let us know which enzymes are you thinking about? and which combinations?

@cecilia992
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Two of the enzymes I have encountered in multiple digestions are Lys-C and Trypsin. The sample is first digested with Lys-C and then with Trypsin in my case.

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@ypriverol @cecilia992