diff --git a/rnacentral/apiv1/views.py b/rnacentral/apiv1/views.py
index 5b3ef0ef1..56acff89a 100644
--- a/rnacentral/apiv1/views.py
+++ b/rnacentral/apiv1/views.py
@@ -48,6 +48,7 @@
 from django.http import Http404, HttpResponse
 from django.shortcuts import get_object_or_404
 from django_filters import rest_framework as filters
+from drf_spectacular.utils import extend_schema
 from portal.config.expert_databases import expert_dbs
 from portal.models import (
     Accession,
@@ -182,6 +183,7 @@ def get(self, request, species, chromosome, start, end, format=None):
         return Response(features)
 
 
+@extend_schema(exclude=True)
 class APIRoot(APIView):
     """
     This is the root of the RNAcentral API Version 1.
diff --git a/rnacentral/portal/templates/portal/header.html b/rnacentral/portal/templates/portal/header.html
index 390bc105d..5176c600b 100644
--- a/rnacentral/portal/templates/portal/header.html
+++ b/rnacentral/portal/templates/portal/header.html
@@ -91,6 +91,7 @@
           <ul class="dropdown-menu">
             <li><a href="{% url 'api-v1-root' %}">Browsable API</a></li>
             <li><a href="{% url 'api-docs' %}">API Documentation</a></li>
+            <li><a href="{% url 'swagger-ui' %}" target="_blank">OpenAPI Schema</a></li>
           </ul>
         </li>
 
diff --git a/rnacentral/requirements.txt b/rnacentral/requirements.txt
index 0873ac174..9465477eb 100644
--- a/rnacentral/requirements.txt
+++ b/rnacentral/requirements.txt
@@ -37,3 +37,6 @@ whitenoise==5.2.0
 
 # AWS SDK for Python
 boto3==1.17.54
+
+# drf-spectacular for OpenAPI schema generation
+drf_spectacular
diff --git a/rnacentral/rnacentral/settings.py b/rnacentral/rnacentral/settings.py
index 0e26f7a35..de4f66eb6 100644
--- a/rnacentral/rnacentral/settings.py
+++ b/rnacentral/rnacentral/settings.py
@@ -191,6 +191,7 @@
     "rest_framework",
     "compressor",
     "markdown_deux",
+    "drf_spectacular",
     # Uncomment the next line to enable admin documentation:
     # 'django.contrib.admindocs',
 )
@@ -251,6 +252,7 @@
     "DEFAULT_PERMISSION_CLASSES": [
         "rest_framework.permissions.DjangoModelPermissionsOrAnonReadOnly"
     ],
+    "DEFAULT_AUTHENTICATION_CLASSES": [],
     # API results pagination
     "DEFAULT_PAGINATION_CLASS": "rnacentral.utils.pagination.Pagination",
     "PAGE_SIZE": 10,
@@ -271,6 +273,19 @@
         "rest_framework_yaml.renderers.YAMLRenderer",
         "rest_framework.renderers.BrowsableAPIRenderer",
     ),
+    "DEFAULT_SCHEMA_CLASS": "drf_spectacular.openapi.AutoSchema",
+}
+
+SPECTACULAR_SETTINGS = {
+    "TITLE": "RNAcentral API",
+    "DESCRIPTION": "RNAcentral API provides programmatic access to RNAcentral data",
+    "VERSION": "1.0.0",
+    "SERVE_INCLUDE_SCHEMA": False,
+    "POSTPROCESSING_HOOKS": [
+        "rnacentral.utils.drf_spectacular.remove_path",
+        "rnacentral.utils.drf_spectacular.fix_path",
+    ],
+    "SCHEMA_PATH_PREFIX": r"/api/v[0-9]",
 }
 
 # django-debug-toolbar
diff --git a/rnacentral/rnacentral/urls.py b/rnacentral/rnacentral/urls.py
index c477ca4b9..162b60653 100644
--- a/rnacentral/rnacentral/urls.py
+++ b/rnacentral/rnacentral/urls.py
@@ -15,6 +15,7 @@
 
 from django.conf.urls import include, url
 from django.views.generic import TemplateView
+from drf_spectacular.views import SpectacularAPIView, SpectacularSwaggerView
 
 urlpatterns = [
     # RNAcentral portal
@@ -27,6 +28,13 @@
     # new sequence search
     url(r"^sequence-search/", include("sequence_search.urls")),
     # Django Debug Toolbar
+    # OpenAPI schema
+    url(r"^api/schema/$", SpectacularAPIView.as_view(), name="schema"),
+    url(
+        r"^api/schema/swagger-ui/$",
+        SpectacularSwaggerView.as_view(url_name="schema"),
+        name="swagger-ui",
+    ),
 ]
 
 # robots.txt extras
diff --git a/rnacentral/rnacentral/utils/drf_spectacular.py b/rnacentral/rnacentral/utils/drf_spectacular.py
new file mode 100644
index 000000000..576bbe2bc
--- /dev/null
+++ b/rnacentral/rnacentral/utils/drf_spectacular.py
@@ -0,0 +1,31 @@
+def remove_path(result, generator, request, public):
+    """
+    Post-processing hook to remove /api/current/ and /sequence-search/ from the schema
+    """
+    paths = result.get("paths", {})
+    excluded_prefixes = ("/api/current/", "/sequence-search/")
+    paths = {
+        key: value
+        for key, value in paths.items()
+        if not key.startswith(excluded_prefixes)
+    }
+    result["paths"] = paths
+    return result
+
+
+def fix_path(result, generator, request, public):
+    """
+    Post-processing hook to normalize paths in the OpenAPI schema:
+    - Fix RNA path patterns containing [_/] to only show /.
+    """
+    paths = result.get("paths", {})
+    updated_paths = {}
+
+    for path, details in paths.items():
+        if "[/_]" in path:
+            path = path.replace("[/_]", "/")
+
+        updated_paths[path] = details
+
+    result["paths"] = updated_paths
+    return result