diff --git a/pcsx2-qt/Debugger/SymbolTree/SymbolTreeDelegates.cpp b/pcsx2-qt/Debugger/SymbolTree/SymbolTreeDelegates.cpp
index c9aaa6be7708a..1905e2ef76883 100644
--- a/pcsx2-qt/Debugger/SymbolTree/SymbolTreeDelegates.cpp
+++ b/pcsx2-qt/Debugger/SymbolTree/SymbolTreeDelegates.cpp
@@ -13,9 +13,11 @@
 
 SymbolTreeLocationDelegate::SymbolTreeLocationDelegate(
 	SymbolGuardian& guardian,
+	u32 alignment,
 	QObject* parent)
 	: QStyledItemDelegate(parent)
 	, m_guardian(guardian)
+	, m_alignment(alignment)
 {
 }
 
@@ -75,6 +77,8 @@ void SymbolTreeLocationDelegate::setModelData(QWidget* editor, QAbstractItemMode
 	if (!ok)
 		return;
 
+	address -= address % m_alignment;
+
 	bool success = false;
 	m_guardian.BlockingReadWrite([&](ccc::SymbolDatabase& database) {
 		if (node->symbol.move_symbol(address, database))
diff --git a/pcsx2-qt/Debugger/SymbolTree/SymbolTreeDelegates.h b/pcsx2-qt/Debugger/SymbolTree/SymbolTreeDelegates.h
index 7e0f8e45b541e..3bfcacc4c9ced 100644
--- a/pcsx2-qt/Debugger/SymbolTree/SymbolTreeDelegates.h
+++ b/pcsx2-qt/Debugger/SymbolTree/SymbolTreeDelegates.h
@@ -14,6 +14,7 @@ class SymbolTreeLocationDelegate : public QStyledItemDelegate
 public:
 	SymbolTreeLocationDelegate(
 		SymbolGuardian& guardian,
+		u32 alignment,
 		QObject* parent = nullptr);
 
 	QWidget* createEditor(QWidget* parent, const QStyleOptionViewItem& option, const QModelIndex& index) const override;
@@ -22,6 +23,7 @@ class SymbolTreeLocationDelegate : public QStyledItemDelegate
 
 protected:
 	SymbolGuardian& m_guardian;
+	u32 m_alignment;
 };
 
 class SymbolTreeTypeDelegate : public QStyledItemDelegate
diff --git a/pcsx2-qt/Debugger/SymbolTree/SymbolTreeWidgets.cpp b/pcsx2-qt/Debugger/SymbolTree/SymbolTreeWidgets.cpp
index 2d655836fce3e..010cbfb9535ae 100644
--- a/pcsx2-qt/Debugger/SymbolTree/SymbolTreeWidgets.cpp
+++ b/pcsx2-qt/Debugger/SymbolTree/SymbolTreeWidgets.cpp
@@ -8,14 +8,14 @@
 #include <QtWidgets/QMenu>
 #include <QtWidgets/QMessageBox>
 
-#include "common/Assertions.h"
 #include "NewSymbolDialogs.h"
 #include "SymbolTreeDelegates.h"
 
-SymbolTreeWidget::SymbolTreeWidget(u32 flags, DebugInterface& cpu, QWidget* parent)
+SymbolTreeWidget::SymbolTreeWidget(u32 flags, s32 symbol_address_alignment, DebugInterface& cpu, QWidget* parent)
 	: QWidget(parent)
 	, m_cpu(cpu)
 	, m_flags(flags)
+	, m_symbol_address_alignment(symbol_address_alignment)
 {
 	m_ui.setupUi(this);
 
@@ -66,7 +66,7 @@ void SymbolTreeWidget::setupTree()
 	m_model = new SymbolTreeModel(m_cpu, this);
 	m_ui.treeView->setModel(m_model);
 
-	auto location_delegate = new SymbolTreeLocationDelegate(m_cpu.GetSymbolGuardian(), this);
+	auto location_delegate = new SymbolTreeLocationDelegate(m_cpu.GetSymbolGuardian(), m_symbol_address_alignment, this);
 	m_ui.treeView->setItemDelegateForColumn(SymbolTreeModel::LOCATION, location_delegate);
 
 	auto type_delegate = new SymbolTreeTypeDelegate(m_cpu.GetSymbolGuardian(), this);
@@ -448,7 +448,7 @@ SymbolTreeNode* SymbolTreeWidget::currentNode()
 }
 
 FunctionTreeWidget::FunctionTreeWidget(DebugInterface& cpu, QWidget* parent)
-	: SymbolTreeWidget(ALLOW_GROUPING, cpu, parent)
+	: SymbolTreeWidget(ALLOW_GROUPING, 4, cpu, parent)
 {
 }
 
@@ -535,7 +535,7 @@ void FunctionTreeWidget::onDeleteButtonPressed()
 }
 
 GlobalVariableTreeWidget::GlobalVariableTreeWidget(DebugInterface& cpu, QWidget* parent)
-	: SymbolTreeWidget(ALLOW_GROUPING | ALLOW_SORTING_BY_IF_TYPE_IS_KNOWN | ALLOW_TYPE_ACTIONS, cpu, parent)
+	: SymbolTreeWidget(ALLOW_GROUPING | ALLOW_SORTING_BY_IF_TYPE_IS_KNOWN | ALLOW_TYPE_ACTIONS, 1, cpu, parent)
 {
 }
 
@@ -649,7 +649,7 @@ void GlobalVariableTreeWidget::onDeleteButtonPressed()
 }
 
 LocalVariableTreeWidget::LocalVariableTreeWidget(DebugInterface& cpu, QWidget* parent)
-	: SymbolTreeWidget(ALLOW_TYPE_ACTIONS, cpu, parent)
+	: SymbolTreeWidget(ALLOW_TYPE_ACTIONS, 1, cpu, parent)
 {
 }
 
@@ -747,7 +747,7 @@ void LocalVariableTreeWidget::onDeleteButtonPressed()
 }
 
 ParameterVariableTreeWidget::ParameterVariableTreeWidget(DebugInterface& cpu, QWidget* parent)
-	: SymbolTreeWidget(ALLOW_TYPE_ACTIONS, cpu, parent)
+	: SymbolTreeWidget(ALLOW_TYPE_ACTIONS, 1, cpu, parent)
 {
 }
 
diff --git a/pcsx2-qt/Debugger/SymbolTree/SymbolTreeWidgets.h b/pcsx2-qt/Debugger/SymbolTree/SymbolTreeWidgets.h
index 5ecb01437e163..fc4139d000dad 100644
--- a/pcsx2-qt/Debugger/SymbolTree/SymbolTreeWidgets.h
+++ b/pcsx2-qt/Debugger/SymbolTree/SymbolTreeWidgets.h
@@ -28,7 +28,7 @@ class SymbolTreeWidget : public QWidget
 	void locationColumnClicked(u32 address);
 
 protected:
-	explicit SymbolTreeWidget(u32 flags, DebugInterface& cpu, QWidget* parent = nullptr);
+	explicit SymbolTreeWidget(u32 flags, s32 symbol_address_alignment, DebugInterface& cpu, QWidget* parent = nullptr);
 
 	void setupTree();
 	void setupMenu();
@@ -89,6 +89,7 @@ class SymbolTreeWidget : public QWidget
 	};
 
 	u32 m_flags;
+	u32 m_symbol_address_alignment;
 };
 
 class FunctionTreeWidget : public SymbolTreeWidget