diff --git a/inst/models/pk_pegasparaginase_modified_wurthwein.json5 b/inst/models/pk_pegasparaginase_modified_wurthwein.json5 index c083d37..ec5458b 100644 --- a/inst/models/pk_pegasparaginase_modified_wurthwein.json5 +++ b/inst/models/pk_pegasparaginase_modified_wurthwein.json5 @@ -1,11 +1,5 @@ { "id": "pk_pegasparaginase_modified_wurthwein", - "description": "PK model for PEG-asparagainase children", - "drug": "peg-asparaginase", - "category": "oncology", - "age_categories": [ "children" ], - "equations": [ - ], "ode_code": "\ dAdt[0] = - (CLi/Vi + Qi/Vi) * A[0] \ dAdt[1] = + (Qi/Vi)*A[0] - (CLi/Vi + Qi/Vi)*A[1] \ @@ -65,45 +59,16 @@ "timevarying_parameter": false, "init_parameter": false }, - "development": { - "n_patients": 1374, - "n_tdms": 6069, - "age": { "median": 5.13, "minimum": 1.03 , "maximum": 17.9 , "unit": "years" }, - "weight": { "median": 19.55, "minimum": 8.5 , "maximum": 128, "unit": "kg" }, - "height": { "median": 113, "minimum": 71, "maximum": 195, "unit": "cm" }, - "sex": { "male": 779, "female": 595} - }, - "external_validation": [], "references": [ { "ref": "Würthwein et al. European Journal of Drug Metabolism and Pharmacokinetics. 2021", "url": "https://link.springer.com/article/10.1007/s13318-021-00670-8#Sec181" } ], - "active": true, - "build": true, - "admin": [ - { - "implementer": { "name": "Jordan Brooks", "email": "jordan.brooks@insight-rx.com" }, - "format": "PKPDsim" - }, - { - "implementer": { "name": "Jordan Brooks", "email": "jordan.brooks@insight-rx.com" }, - "format": "NONMEM" - } - ], - "implementations": { - "nonmem": "pk_pegasparaginase_modified_wurthwein.mod" - }, "comments": [ "Utilizing updated/simplified model from 2021 publication.", "Removed IOV and specific occasion effects on CL & V, which were specific to the trial and not generalizable to real-world application.", "Re-estimated IIV on CLP, which was much larger than original publication. Larger IIV is in line with literature and clinical understanding about high variability in peg-asparaginase PK." ], - "validation": { - "implementation": true, - "numerical": true, - "clinical": false - }, "version": "0.1.4" }