-
Notifications
You must be signed in to change notification settings - Fork 0
/
figure6_I_Cl.py
203 lines (163 loc) · 11.7 KB
/
figure6_I_Cl.py
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
import numpy as np
from edNEGmodel.edNEGmodel import *
from functions.solve_edNEGmodel_figure6 import *
from functions.split_phi_e__injection_stimuli import *
alpha = 2
# Physiological activity
t_dur = 60 # [s]
stim_start = 1 # [s]
stim_end = 60 # [s]
injection_protocol = 'Cl_soma_ss'
dendritic_stimuli = False
k = 1
for I_stim_ in range(50, 90, 10):
I_stim = I_stim_*1e-12
sol, my_cell = solve_edNEGmodel(t_dur, alpha, I_stim, stim_start, stim_end, injection_protocol)
t = sol.t
phi_sn, phi_se, phi_sg, phi_dn, phi_de, phi_dg, phi_msn, phi_mdn, phi_msg, phi_mdg = my_cell.membrane_potentials()
E_Na_sn, E_Na_sg, E_Na_dn, E_Na_dg, E_K_sn, E_K_sg, E_K_dn, E_K_dg, E_Cl_sn, E_Cl_sg, E_Cl_dn, E_Cl_dg, E_Ca_sn, E_Ca_dn = my_cell.reversal_potentials()
phi_e_n, phi_e_g, phi_e_diff = split_phi_e(my_cell, t, I_stim, stim_start, stim_end, dendritic_stimuli)
np.savez('data/figure6_Cl_soma_ss_' + str(k), t=t, phi_sn=phi_sn, phi_se=phi_se, phi_dn=phi_dn, phi_de=phi_de, phi_sg=phi_sg, phi_dg=phi_dg, \
phi_msn=phi_msn, phi_mdn=phi_mdn, phi_msg=phi_msg, phi_mdg=phi_mdg, \
E_Na_sn=E_Na_sn, E_Na_dn=E_Na_dn, E_Na_sg=E_Na_sg, E_Na_dg=E_Na_dg, \
E_K_sn=E_K_sn, E_K_dn=E_K_dn, E_K_sg=E_K_sg, E_K_dg=E_K_dg, \
E_Cl_sn=E_Cl_sn, E_Cl_dn=E_Cl_dn, E_Cl_sg=E_Cl_sg, E_Cl_dg=E_Cl_dg, \
E_Ca_sn=E_Ca_sn, E_Ca_dn=E_Ca_dn, \
cNa_sn=my_cell.cNa_sn, cNa_se=my_cell.cNa_se, cNa_sg=my_cell.cNa_sg, cNa_dn=my_cell.cNa_dn, cNa_de=my_cell.cNa_de, cNa_dg=my_cell.cNa_dg, \
cK_sn=my_cell.cK_sn, cK_se=my_cell.cK_se, cK_sg=my_cell.cK_sg, cK_dn=my_cell.cK_dn, cK_de=my_cell.cK_de, cK_dg=my_cell.cK_dg, \
cCl_sn=my_cell.cCl_sn, cCl_se=my_cell.cCl_se, cCl_sg=my_cell.cCl_sg, cCl_dn=my_cell.cCl_dn, cCl_de=my_cell.cCl_de, cCl_dg=my_cell.cCl_dg, \
cCa_sn=my_cell.cCa_sn, cCa_se=my_cell.cCa_se, cCa_dn=my_cell.cCa_dn, cCa_de=my_cell.cCa_de, \
free_cCa_dn=my_cell.free_cCa_dn, \
V_sn = my_cell.V_sn, V_se = my_cell.V_se, V_sg = my_cell.V_sg, \
V_dn = my_cell.V_dn, V_de = my_cell.V_de, V_dg = my_cell.V_dg, \
phi_e_n=phi_e_n, phi_e_g=phi_e_g, phi_e_diff=phi_e_diff, I_stim=I_stim)
k += 1
injection_protocol = 'Cl_dendrite_ss'
dendritic_stimuli = True
k = 1
for I_stim_ in range(50, 90, 10):
I_stim = I_stim_*1e-12
sol, my_cell = solve_edNEGmodel(t_dur, alpha, I_stim, stim_start, stim_end, injection_protocol)
t = sol.t
phi_sn, phi_se, phi_sg, phi_dn, phi_de, phi_dg, phi_msn, phi_mdn, phi_msg, phi_mdg = my_cell.membrane_potentials()
E_Na_sn, E_Na_sg, E_Na_dn, E_Na_dg, E_K_sn, E_K_sg, E_K_dn, E_K_dg, E_Cl_sn, E_Cl_sg, E_Cl_dn, E_Cl_dg, E_Ca_sn, E_Ca_dn = my_cell.reversal_potentials()
phi_e_n, phi_e_g, phi_e_diff = split_phi_e(my_cell, t, I_stim, stim_start, stim_end, dendritic_stimuli)
np.savez('data/figure6_Cl_dendrite_ss_' + str(k), t=t, phi_sn=phi_sn, phi_se=phi_se, phi_dn=phi_dn, phi_de=phi_de, phi_sg=phi_sg, phi_dg=phi_dg, \
phi_msn=phi_msn, phi_mdn=phi_mdn, phi_msg=phi_msg, phi_mdg=phi_mdg, \
E_Na_sn=E_Na_sn, E_Na_dn=E_Na_dn, E_Na_sg=E_Na_sg, E_Na_dg=E_Na_dg, \
E_K_sn=E_K_sn, E_K_dn=E_K_dn, E_K_sg=E_K_sg, E_K_dg=E_K_dg, \
E_Cl_sn=E_Cl_sn, E_Cl_dn=E_Cl_dn, E_Cl_sg=E_Cl_sg, E_Cl_dg=E_Cl_dg, \
E_Ca_sn=E_Ca_sn, E_Ca_dn=E_Ca_dn, \
cNa_sn=my_cell.cNa_sn, cNa_se=my_cell.cNa_se, cNa_sg=my_cell.cNa_sg, cNa_dn=my_cell.cNa_dn, cNa_de=my_cell.cNa_de, cNa_dg=my_cell.cNa_dg, \
cK_sn=my_cell.cK_sn, cK_se=my_cell.cK_se, cK_sg=my_cell.cK_sg, cK_dn=my_cell.cK_dn, cK_de=my_cell.cK_de, cK_dg=my_cell.cK_dg, \
cCl_sn=my_cell.cCl_sn, cCl_se=my_cell.cCl_se, cCl_sg=my_cell.cCl_sg, cCl_dn=my_cell.cCl_dn, cCl_de=my_cell.cCl_de, cCl_dg=my_cell.cCl_dg, \
cCa_sn=my_cell.cCa_sn, cCa_se=my_cell.cCa_se, cCa_dn=my_cell.cCa_dn, cCa_de=my_cell.cCa_de, \
free_cCa_dn=my_cell.free_cCa_dn, \
V_sn = my_cell.V_sn, V_se = my_cell.V_se, V_sg = my_cell.V_sg, \
V_dn = my_cell.V_dn, V_de = my_cell.V_de, V_dg = my_cell.V_dg, \
phi_e_n=phi_e_n, phi_e_g=phi_e_g, phi_e_diff=phi_e_diff, I_stim=I_stim)
k += 1
injection_protocol = 'Cl_both_ss'
dendritic_stimuli = True
k = 1
for I_stim_ in range(10, 50, 10):
I_stim = I_stim_*1e-12
sol, my_cell = solve_edNEGmodel(t_dur, alpha, I_stim, stim_start, stim_end, injection_protocol)
t = sol.t
phi_sn, phi_se, phi_sg, phi_dn, phi_de, phi_dg, phi_msn, phi_mdn, phi_msg, phi_mdg = my_cell.membrane_potentials()
E_Na_sn, E_Na_sg, E_Na_dn, E_Na_dg, E_K_sn, E_K_sg, E_K_dn, E_K_dg, E_Cl_sn, E_Cl_sg, E_Cl_dn, E_Cl_dg, E_Ca_sn, E_Ca_dn = my_cell.reversal_potentials()
phi_e_n, phi_e_g, phi_e_diff = split_phi_e(my_cell, t, I_stim, stim_start, stim_end, dendritic_stimuli)
np.savez('data/figure6_Cl_both_ss_' + str(k), t=t, phi_sn=phi_sn, phi_se=phi_se, phi_dn=phi_dn, phi_de=phi_de, phi_sg=phi_sg, phi_dg=phi_dg, \
phi_msn=phi_msn, phi_mdn=phi_mdn, phi_msg=phi_msg, phi_mdg=phi_mdg, \
E_Na_sn=E_Na_sn, E_Na_dn=E_Na_dn, E_Na_sg=E_Na_sg, E_Na_dg=E_Na_dg, \
E_K_sn=E_K_sn, E_K_dn=E_K_dn, E_K_sg=E_K_sg, E_K_dg=E_K_dg, \
E_Cl_sn=E_Cl_sn, E_Cl_dn=E_Cl_dn, E_Cl_sg=E_Cl_sg, E_Cl_dg=E_Cl_dg, \
E_Ca_sn=E_Ca_sn, E_Ca_dn=E_Ca_dn, \
cNa_sn=my_cell.cNa_sn, cNa_se=my_cell.cNa_se, cNa_sg=my_cell.cNa_sg, cNa_dn=my_cell.cNa_dn, cNa_de=my_cell.cNa_de, cNa_dg=my_cell.cNa_dg, \
cK_sn=my_cell.cK_sn, cK_se=my_cell.cK_se, cK_sg=my_cell.cK_sg, cK_dn=my_cell.cK_dn, cK_de=my_cell.cK_de, cK_dg=my_cell.cK_dg, \
cCl_sn=my_cell.cCl_sn, cCl_se=my_cell.cCl_se, cCl_sg=my_cell.cCl_sg, cCl_dn=my_cell.cCl_dn, cCl_de=my_cell.cCl_de, cCl_dg=my_cell.cCl_dg, \
cCa_sn=my_cell.cCa_sn, cCa_se=my_cell.cCa_se, cCa_dn=my_cell.cCa_dn, cCa_de=my_cell.cCa_de, \
free_cCa_dn=my_cell.free_cCa_dn, \
V_sn = my_cell.V_sn, V_se = my_cell.V_se, V_sg = my_cell.V_sg, \
V_dn = my_cell.V_dn, V_de = my_cell.V_de, V_dg = my_cell.V_dg, \
phi_e_n=phi_e_n, phi_e_g=phi_e_g, phi_e_diff=phi_e_diff, I_stim=I_stim)
k += 1
# Pathological activity
t_dur = 600 # [s]
stim_start = 1 # [s]
stim_end = 60 # [s]
injection_protocol = 'Cl_soma_db'
dendritic_stimuli = False
k = 1
for I_stim_ in range(90, 121, 10):
I_stim = I_stim_*1e-12
sol, my_cell = solve_edNEGmodel(t_dur, alpha, I_stim, stim_start, stim_end, injection_protocol)
t = sol.t
phi_sn, phi_se, phi_sg, phi_dn, phi_de, phi_dg, phi_msn, phi_mdn, phi_msg, phi_mdg = my_cell.membrane_potentials()
E_Na_sn, E_Na_sg, E_Na_dn, E_Na_dg, E_K_sn, E_K_sg, E_K_dn, E_K_dg, E_Cl_sn, E_Cl_sg, E_Cl_dn, E_Cl_dg, E_Ca_sn, E_Ca_dn = my_cell.reversal_potentials()
phi_e_n, phi_e_g, phi_e_diff = split_phi_e(my_cell, t, I_stim, stim_start, stim_end, dendritic_stimuli)
np.savez('data/figure6_Cl_soma_db_' + str(k), t=t, phi_sn=phi_sn, phi_se=phi_se, phi_dn=phi_dn, phi_de=phi_de, phi_sg=phi_sg, phi_dg=phi_dg, \
phi_msn=phi_msn, phi_mdn=phi_mdn, phi_msg=phi_msg, phi_mdg=phi_mdg, \
E_Na_sn=E_Na_sn, E_Na_dn=E_Na_dn, E_Na_sg=E_Na_sg, E_Na_dg=E_Na_dg, \
E_K_sn=E_K_sn, E_K_dn=E_K_dn, E_K_sg=E_K_sg, E_K_dg=E_K_dg, \
E_Cl_sn=E_Cl_sn, E_Cl_dn=E_Cl_dn, E_Cl_sg=E_Cl_sg, E_Cl_dg=E_Cl_dg, \
E_Ca_sn=E_Ca_sn, E_Ca_dn=E_Ca_dn, \
cNa_sn=my_cell.cNa_sn, cNa_se=my_cell.cNa_se, cNa_sg=my_cell.cNa_sg, cNa_dn=my_cell.cNa_dn, cNa_de=my_cell.cNa_de, cNa_dg=my_cell.cNa_dg, \
cK_sn=my_cell.cK_sn, cK_se=my_cell.cK_se, cK_sg=my_cell.cK_sg, cK_dn=my_cell.cK_dn, cK_de=my_cell.cK_de, cK_dg=my_cell.cK_dg, \
cCl_sn=my_cell.cCl_sn, cCl_se=my_cell.cCl_se, cCl_sg=my_cell.cCl_sg, cCl_dn=my_cell.cCl_dn, cCl_de=my_cell.cCl_de, cCl_dg=my_cell.cCl_dg, \
cCa_sn=my_cell.cCa_sn, cCa_se=my_cell.cCa_se, cCa_dn=my_cell.cCa_dn, cCa_de=my_cell.cCa_de, \
free_cCa_dn=my_cell.free_cCa_dn, \
V_sn = my_cell.V_sn, V_se = my_cell.V_se, V_sg = my_cell.V_sg, \
V_dn = my_cell.V_dn, V_de = my_cell.V_de, V_dg = my_cell.V_dg, \
phi_e_n=phi_e_n, phi_e_g=phi_e_g, phi_e_diff=phi_e_diff, I_stim=I_stim)
k += 1
injection_protocol = 'Cl_dendrite_db'
dendritic_stimuli = True
k = 1
for I_stim_ in range(90, 121, 10):
I_stim = I_stim_*1e-12
sol, my_cell = solve_edNEGmodel(t_dur, alpha, I_stim, stim_start, stim_end, injection_protocol)
t = sol.t
phi_sn, phi_se, phi_sg, phi_dn, phi_de, phi_dg, phi_msn, phi_mdn, phi_msg, phi_mdg = my_cell.membrane_potentials()
E_Na_sn, E_Na_sg, E_Na_dn, E_Na_dg, E_K_sn, E_K_sg, E_K_dn, E_K_dg, E_Cl_sn, E_Cl_sg, E_Cl_dn, E_Cl_dg, E_Ca_sn, E_Ca_dn = my_cell.reversal_potentials()
phi_e_n, phi_e_g, phi_e_diff = split_phi_e(my_cell, t, I_stim, stim_start, stim_end, dendritic_stimuli)
np.savez('data/figure6_Cl_dendrite_db_' + str(k), t=t, phi_sn=phi_sn, phi_se=phi_se, phi_dn=phi_dn, phi_de=phi_de, phi_sg=phi_sg, phi_dg=phi_dg, \
phi_msn=phi_msn, phi_mdn=phi_mdn, phi_msg=phi_msg, phi_mdg=phi_mdg, \
E_Na_sn=E_Na_sn, E_Na_dn=E_Na_dn, E_Na_sg=E_Na_sg, E_Na_dg=E_Na_dg, \
E_K_sn=E_K_sn, E_K_dn=E_K_dn, E_K_sg=E_K_sg, E_K_dg=E_K_dg, \
E_Cl_sn=E_Cl_sn, E_Cl_dn=E_Cl_dn, E_Cl_sg=E_Cl_sg, E_Cl_dg=E_Cl_dg, \
E_Ca_sn=E_Ca_sn, E_Ca_dn=E_Ca_dn, \
cNa_sn=my_cell.cNa_sn, cNa_se=my_cell.cNa_se, cNa_sg=my_cell.cNa_sg, cNa_dn=my_cell.cNa_dn, cNa_de=my_cell.cNa_de, cNa_dg=my_cell.cNa_dg, \
cK_sn=my_cell.cK_sn, cK_se=my_cell.cK_se, cK_sg=my_cell.cK_sg, cK_dn=my_cell.cK_dn, cK_de=my_cell.cK_de, cK_dg=my_cell.cK_dg, \
cCl_sn=my_cell.cCl_sn, cCl_se=my_cell.cCl_se, cCl_sg=my_cell.cCl_sg, cCl_dn=my_cell.cCl_dn, cCl_de=my_cell.cCl_de, cCl_dg=my_cell.cCl_dg, \
cCa_sn=my_cell.cCa_sn, cCa_se=my_cell.cCa_se, cCa_dn=my_cell.cCa_dn, cCa_de=my_cell.cCa_de, \
free_cCa_dn=my_cell.free_cCa_dn, \
V_sn = my_cell.V_sn, V_se = my_cell.V_se, V_sg = my_cell.V_sg, \
V_dn = my_cell.V_dn, V_de = my_cell.V_de, V_dg = my_cell.V_dg, \
phi_e_n=phi_e_n, phi_e_g=phi_e_g, phi_e_diff=phi_e_diff, I_stim=I_stim)
k += 1
injection_protocol = 'Cl_both_db'
dendritic_stimuli = True
k = 1
for I_stim_ in range(50, 81, 10):
I_stim = I_stim_*1e-12
sol, my_cell = solve_edNEGmodel(t_dur, alpha, I_stim, stim_start, stim_end, injection_protocol)
t = sol.t
phi_sn, phi_se, phi_sg, phi_dn, phi_de, phi_dg, phi_msn, phi_mdn, phi_msg, phi_mdg = my_cell.membrane_potentials()
E_Na_sn, E_Na_sg, E_Na_dn, E_Na_dg, E_K_sn, E_K_sg, E_K_dn, E_K_dg, E_Cl_sn, E_Cl_sg, E_Cl_dn, E_Cl_dg, E_Ca_sn, E_Ca_dn = my_cell.reversal_potentials()
phi_e_n, phi_e_g, phi_e_diff = split_phi_e(my_cell, t, I_stim, stim_start, stim_end, dendritic_stimuli)
np.savez('data/figure6_Cl_both_db_' + str(k), t=t, phi_sn=phi_sn, phi_se=phi_se, phi_dn=phi_dn, phi_de=phi_de, phi_sg=phi_sg, phi_dg=phi_dg, \
phi_msn=phi_msn, phi_mdn=phi_mdn, phi_msg=phi_msg, phi_mdg=phi_mdg, \
E_Na_sn=E_Na_sn, E_Na_dn=E_Na_dn, E_Na_sg=E_Na_sg, E_Na_dg=E_Na_dg, \
E_K_sn=E_K_sn, E_K_dn=E_K_dn, E_K_sg=E_K_sg, E_K_dg=E_K_dg, \
E_Cl_sn=E_Cl_sn, E_Cl_dn=E_Cl_dn, E_Cl_sg=E_Cl_sg, E_Cl_dg=E_Cl_dg, \
E_Ca_sn=E_Ca_sn, E_Ca_dn=E_Ca_dn, \
cNa_sn=my_cell.cNa_sn, cNa_se=my_cell.cNa_se, cNa_sg=my_cell.cNa_sg, cNa_dn=my_cell.cNa_dn, cNa_de=my_cell.cNa_de, cNa_dg=my_cell.cNa_dg, \
cK_sn=my_cell.cK_sn, cK_se=my_cell.cK_se, cK_sg=my_cell.cK_sg, cK_dn=my_cell.cK_dn, cK_de=my_cell.cK_de, cK_dg=my_cell.cK_dg, \
cCl_sn=my_cell.cCl_sn, cCl_se=my_cell.cCl_se, cCl_sg=my_cell.cCl_sg, cCl_dn=my_cell.cCl_dn, cCl_de=my_cell.cCl_de, cCl_dg=my_cell.cCl_dg, \
cCa_sn=my_cell.cCa_sn, cCa_se=my_cell.cCa_se, cCa_dn=my_cell.cCa_dn, cCa_de=my_cell.cCa_de, \
free_cCa_dn=my_cell.free_cCa_dn, \
V_sn = my_cell.V_sn, V_se = my_cell.V_se, V_sg = my_cell.V_sg, \
V_dn = my_cell.V_dn, V_de = my_cell.V_de, V_dg = my_cell.V_dg, \
phi_e_n=phi_e_n, phi_e_g=phi_e_g, phi_e_diff=phi_e_diff, I_stim=I_stim)
k += 1