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</head><body><pre>
fire haldol - Psychosis
.1mg of zyprexa
water zyprexa
earth fireworks
air ?
drevil ?
sleep melatonin rozerem
relax l theanine - good for akathasia of the legs
tastegood
vanilla
apple
kangroo biplar
</pre>Comparing the affinities of different drugs. Risperidone prolactin can cause infertility in some people. Sulpiride, Solian<br>
MAOIs<br>
RIMAs<br>
TCAs<br>
antidepressants, antihistamines, anti-anxiety medications, muscle relaxants, tranquilizers, sleeping pills, and pain medications given after surgery.
<input type="range" style="position:fixed;top:10px;right:10px;"><br>
<table class="wikitable">
<tbody><tr>
<th>Class
</th>
<th>Drugs that can induce serotonin syndrome
</th></tr>
<tr>
<td><a href="/wiki/Antidepressant" title="Antidepressant">Antidepressants</a>
</td>
<td><a href="/wiki/Monoamine_oxidase_inhibitor" title="Monoamine oxidase inhibitor">Monoamine oxidase inhibitors (MAOIs)</a>,<sup id="cite_ref-Boy2005_4-6" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">TCAs</a>,<sup id="cite_ref-Boy2005_4-7" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/SSRI" class="mw-redirect" title="SSRI">SSRIs</a>,<sup id="cite_ref-Boy2005_4-8" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Serotonin-norepinephrine_reuptake_inhibitor" class="mw-redirect" title="Serotonin-norepinephrine reuptake inhibitor">SNRIs</a>,<sup id="cite_ref-Boy2005_4-9" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Nefazodone" title="Nefazodone">nefazodone</a>,<sup id="cite_ref-Ener_9-0" class="reference"><a href="#cite_note-Ener-9">[9]</a></sup> <a href="/wiki/Trazodone" title="Trazodone">trazodone</a><sup id="cite_ref-Ener_9-1" class="reference"><a href="#cite_note-Ener-9">[9]</a></sup> and <a href="/wiki/Mirtazapine" title="Mirtazapine">mirtazapine</a>.<sup id="cite_ref-Boy2005_4-10" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup>
</td></tr>
<tr>
<td><a href="/wiki/Opioid" title="Opioid">Opioids</a>
</td>
<td><a href="/wiki/Dextropropoxyphene" title="Dextropropoxyphene">Dextropropoxyphene</a>,<sup id="cite_ref-National_Prescribing_Service_10-0" class="reference"><a href="#cite_note-National_Prescribing_Service-10">[10]</a></sup> <a href="/wiki/Tramadol" title="Tramadol">tramadol</a>,<sup id="cite_ref-Boy2005_4-11" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Tapentadol#Adverse_effects" title="Tapentadol">tapentadol</a>, <a href="/wiki/Pethidine" title="Pethidine">pethidine</a> (meperidine),<sup id="cite_ref-Boy2005_4-12" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Fentanyl" title="Fentanyl">fentanyl</a>,<sup id="cite_ref-Boy2005_4-13" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Pentazocine" title="Pentazocine">pentazocine</a>,<sup id="cite_ref-Boy2005_4-14" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Buprenorphine" title="Buprenorphine">buprenorphine</a><sup id="cite_ref-11" class="reference"><a href="#cite_note-11">[11]</a></sup> <a href="/wiki/Oxycodone" title="Oxycodone">oxycodone</a>,<sup id="cite_ref-Gnanadesigan_12-0" class="reference"><a href="#cite_note-Gnanadesigan-12">[12]</a></sup> <a href="/wiki/Hydrocodone" title="Hydrocodone">hydrocodone</a><sup id="cite_ref-Gnanadesigan_12-1" class="reference"><a href="#cite_note-Gnanadesigan-12">[12]</a></sup>
</td></tr>
<tr>
<td>CNS <a href="/wiki/Stimulant" title="Stimulant">stimulants</a>
</td>
<td><a href="/wiki/MDMA" title="MDMA">MDMA</a>,<sup id="cite_ref-Boy2005_4-15" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/3,4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">MDA</a>,<sup id="cite_ref-Boy2005_4-16" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Methamphetamine" title="Methamphetamine">methamphetamine</a>,<sup id="cite_ref-Schep_13-0" class="reference"><a href="#cite_note-Schep-13">[13]</a></sup> <a href="/wiki/Lisdexamfetamine" title="Lisdexamfetamine">lisdexamfetamine</a>,<sup id="cite_ref-14" class="reference"><a href="#cite_note-14">[14]</a></sup> <a href="/wiki/Amphetamine" title="Amphetamine">amphetamine</a>,<sup id="cite_ref-15" class="reference"><a href="#cite_note-15">[15]</a></sup> <a href="/wiki/Phentermine" title="Phentermine">phentermine</a>,<sup id="cite_ref-National_Prescribing_Service_10-1" class="reference"><a href="#cite_note-National_Prescribing_Service-10">[10]</a></sup> <a href="/wiki/Amfepramone" title="Amfepramone">amfepramone</a> (diethylpropion),<sup id="cite_ref-National_Prescribing_Service_10-2" class="reference"><a href="#cite_note-National_Prescribing_Service-10">[10]</a></sup> <a href="/wiki/Serotonin_releasing_agent" title="Serotonin releasing agent">serotonin releasing agents</a><sup id="cite_ref-Isbister_Buckley_7-1" class="reference"><a href="#cite_note-Isbister_Buckley-7">[7]</a></sup> like <a href="/wiki/Hallucinogenic" class="mw-redirect" title="Hallucinogenic">hallucinogenic</a> <a href="/wiki/Substituted_amphetamine" title="Substituted amphetamine">substituted amphetamines</a>,<sup id="cite_ref-National_Prescribing_Service_10-3" class="reference"><a href="#cite_note-National_Prescribing_Service-10">[10]</a></sup> <a href="/wiki/Sibutramine" title="Sibutramine">sibutramine</a>,<sup id="cite_ref-Boy2005_4-17" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Methylphenidate" title="Methylphenidate">methylphenidate</a>,<sup id="cite_ref-National_Prescribing_Service_10-4" class="reference"><a href="#cite_note-National_Prescribing_Service-10">[10]</a></sup> <a href="/wiki/Cocaine" title="Cocaine">cocaine</a><sup id="cite_ref-National_Prescribing_Service_10-5" class="reference"><a href="#cite_note-National_Prescribing_Service-10">[10]</a></sup>
</td></tr>
<tr>
<td><a href="/wiki/5-HT_receptor" title="5-HT receptor">5-HT<sub>1</sub></a> agonists
</td>
<td><a href="/wiki/Triptan" title="Triptan">Triptans</a><sup id="cite_ref-Boy2005_4-18" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup><sup id="cite_ref-National_Prescribing_Service_10-6" class="reference"><a href="#cite_note-National_Prescribing_Service-10">[10]</a></sup>
</td></tr>
<tr>
<td><a href="/wiki/Psychedelics" class="mw-redirect" title="Psychedelics">Psychedelics</a>
</td>
<td><a href="/wiki/5-Methoxy-diisopropyltryptamine" class="mw-redirect" title="5-Methoxy-diisopropyltryptamine">5-Methoxy-diisopropyltryptamine</a>,<sup id="cite_ref-Boy2005_4-19" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Lysergic_acid_diethylamide" title="Lysergic acid diethylamide">LSD</a><sup id="cite_ref-16" class="reference"><a href="#cite_note-16">[16]</a></sup>
</td></tr>
<tr>
<td><a href="/wiki/Herbs" class="mw-redirect" title="Herbs">Herbs</a>
</td>
<td><a href="/wiki/St_John%27s_Wort" class="mw-redirect" title="St John's Wort">St John's Wort</a>,<sup id="cite_ref-Boy2005_4-20" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Syrian_rue" class="mw-redirect" title="Syrian rue">Syrian rue</a>,<sup id="cite_ref-Boy2005_4-21" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Panax_ginseng" title="Panax ginseng">Panax ginseng</a>,<sup id="cite_ref-Boy2005_4-22" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Nutmeg" title="Nutmeg">Nutmeg</a>,<sup id="cite_ref-17" class="reference"><a href="#cite_note-17">[17]</a></sup> <a href="/wiki/Yohimbe" class="mw-redirect" title="Yohimbe">Yohimbe</a><sup id="cite_ref-18" class="reference"><a href="#cite_note-18">[18]</a></sup>
</td></tr>
<tr>
<td>Others
</td>
<td><a href="/wiki/Tryptophan" title="Tryptophan">tryptophan</a>,<sup id="cite_ref-Boy2005_4-23" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/L-Dopa" class="mw-redirect" title="L-Dopa">L-Dopa</a>,<sup id="cite_ref-Birmes_19-0" class="reference"><a href="#cite_note-Birmes-19">[19]</a></sup> <a href="/wiki/Valproate" title="Valproate">valproate</a>,<sup id="cite_ref-Boy2005_4-24" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Buspirone" title="Buspirone">buspirone</a>,<sup id="cite_ref-Boy2005_4-25" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Lithium_(medication)" title="Lithium (medication)">lithium</a>,<sup id="cite_ref-Boy2005_4-26" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Linezolid" title="Linezolid">linezolid</a>,<sup id="cite_ref-Boy2005_4-27" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup><sup id="cite_ref-20" class="reference"><a href="#cite_note-20">[20]</a></sup> <a href="/wiki/Dextromethorphan" title="Dextromethorphan">dextromethorphan</a>,<sup id="cite_ref-Boy2005_4-28" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/5-hydroxytryptophan" class="mw-redirect" title="5-hydroxytryptophan">5-hydroxytryptophan</a>,<sup id="cite_ref-Ener_9-2" class="reference"><a href="#cite_note-Ener-9">[9]</a></sup> <a href="/wiki/Chlorpheniramine" class="mw-redirect" title="Chlorpheniramine">chlorpheniramine</a>,<sup id="cite_ref-National_Prescribing_Service_10-7" class="reference"><a href="#cite_note-National_Prescribing_Service-10">[10]</a></sup> <a href="/wiki/Risperidone" title="Risperidone">risperidone</a>,<sup id="cite_ref-pmid12639169_21-0" class="reference"><a href="#cite_note-pmid12639169-21">[21]</a></sup> <a href="/wiki/Olanzapine" title="Olanzapine">olanzapine</a>,<sup id="cite_ref-Verre_22-0" class="reference"><a href="#cite_note-Verre-22">[22]</a></sup> <a href="/wiki/Ondansetron" title="Ondansetron">ondansetron</a>,<sup id="cite_ref-Boy2005_4-29" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Granisetron" title="Granisetron">granisetron</a>,<sup id="cite_ref-Boy2005_4-30" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Metoclopramide" title="Metoclopramide">metoclopramide</a>,<sup id="cite_ref-Boy2005_4-31" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Ritonavir" title="Ritonavir">ritonavir</a>,<sup id="cite_ref-Boy2005_4-32" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup> <a href="/wiki/Metaxalone" title="Metaxalone">metaxalone</a><sup id="cite_ref-Boy2005_4-33" class="reference"><a href="#cite_note-Boy2005-4">[4]</a></sup>
</td></tr></tbody></table>
<div id="box">,5-HT1A,5-HT1B,5-HT1D,5-HT1E,5-HT1F,5-HT2A,5-HT2B,5-HT2C,5-HT3,5-HT5A,5-HT6,5-HT7,D1,D2,D2L,D2S,D3,D4,D4.2,D4.4,D5,DAT,H1,H2,H3,H4,M1,M2,M3,M4,M5,NET,NMDA
(PCP),Opioid,SERT,Site,VDCC,VGSC,hERG,nACh,α1A,α1B,α2A,α2B,α2C,β1,β2,σ1,σ2</div>
<table border="1" cellspacing="2" cellpadding="0">
<tbody>
<tr>
<td>
<table class="wikitable floatright" style="font-size:small;" width="300">
<caption>Aripiprazole</caption>
<tbody><tr>
<th>Site</th>
<th>K<sub>i</sub> (nM)</th>
<th>Action</th>
</tr>
<tr>
<td><b><a href="/wiki/5-HT1A_receptor" title="5-HT1A receptor">5-HT<sub>1A</sub></a></b></td>
<td><b>1.7–5.6</b></td>
<td><b>Partial agonist</b></td>
</tr>
<tr>
<td><a href="/wiki/5-HT1B_receptor" title="5-HT1B receptor">5-HT<sub>1B</sub></a></td>
<td>830</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/5-HT1D_receptor" title="5-HT1D receptor">5-HT<sub>1D</sub></a></td>
<td>68</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/5-HT1E_receptor" title="5-HT1E receptor">5-HT<sub>1E</sub></a></td>
<td>8,000</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><b><a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">5-HT<sub>2A</sub></a></b></td>
<td><b>3.4–35</b></td>
<td><b>Antagonist</b></td>
</tr>
<tr>
<td><b><a href="/wiki/5-HT2B_receptor" title="5-HT2B receptor">5-HT<sub>2B</sub></a></b></td>
<td><b>0.36</b></td>
<td><b>Inverse agonist</b></td>
</tr>
<tr>
<td><b><a href="/wiki/5-HT2C_receptor" title="5-HT2C receptor">5-HT<sub>2C</sub></a></b></td>
<td><b>15–180</b></td>
<td><b>Partial agonist</b></td>
</tr>
<tr>
<td><a href="/wiki/5-HT3_receptor" title="5-HT3 receptor">5-HT<sub>3</sub></a></td>
<td>628</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/5-HT5A_receptor" title="5-HT5A receptor">5-HT<sub>5A</sub></a></td>
<td>1,240</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/5-HT6_receptor" title="5-HT6 receptor">5-HT<sub>6</sub></a></td>
<td>214–786</td>
<td>Antagonist</td>
</tr>
<tr>
<td><b><a href="/wiki/5-HT7_receptor" title="5-HT7 receptor">5-HT<sub>7</sub></a></b></td>
<td><b>9.6–39</b></td>
<td><b>Antagonist</b></td>
</tr>
<tr>
<td><a href="/wiki/D1_receptor" class="mw-redirect" title="D1 receptor">D<sub>1</sub></a></td>
<td>265–1,170</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><b><a href="/wiki/D2_receptor" class="mw-redirect" title="D2 receptor">D<sub>2</sub></a></b></td>
<td><b>0.45–3.3</b></td>
<td><b>Partial agonist</b></td>
</tr>
<tr>
<td><b><a href="/wiki/Dopamine_D2_receptor" class="mw-redirect" title="Dopamine D2 receptor">D<sub>2L</sub></a></b></td>
<td><b>0.34–0.74</b></td>
<td><b>Partial agonist</b></td>
</tr>
<tr>
<td><b><a href="/wiki/D3_receptor" class="mw-redirect" title="D3 receptor">D<sub>3</sub></a></b></td>
<td><b>0.8–9.7</b></td>
<td><b>Partial agonist</b></td>
</tr>
<tr>
<td><a href="/wiki/D4_receptor" class="mw-redirect" title="D4 receptor">D<sub>4</sub></a></td>
<td>44–514</td>
<td>Partial agonist</td>
</tr>
<tr>
<td><a href="/wiki/D5_receptor" class="mw-redirect" title="D5 receptor">D<sub>5</sub></a></td>
<td>95–2,590</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/Alpha-1A_adrenergic_receptor" title="Alpha-1A adrenergic receptor">α<sub>1A</sub></a></td>
<td>25.9</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/Alpha-1B_adrenergic_receptor" title="Alpha-1B adrenergic receptor">α<sub>1B</sub></a></td>
<td>34.4</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/Alpha-2A_adrenergic_receptor" title="Alpha-2A adrenergic receptor">α<sub>2A</sub></a></td>
<td>74.3</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/Alpha-2B_adrenergic_receptor" title="Alpha-2B adrenergic receptor">α<sub>2B</sub></a></td>
<td>102</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/Alpha-2C_adrenergic_receptor" title="Alpha-2C adrenergic receptor">α<sub>2C</sub></a></td>
<td>37.9</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/Beta-1_adrenergic_receptor" title="Beta-1 adrenergic receptor">β<sub>1</sub></a></td>
<td>141</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/Beta-2_adrenergic_receptor" title="Beta-2 adrenergic receptor">β<sub>2</sub></a></td>
<td>163</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/H1_receptor" class="mw-redirect" title="H1 receptor">H<sub>1</sub></a></td>
<td>27.9–61</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/H2_receptor" class="mw-redirect" title="H2 receptor">H<sub>2</sub></a></td>
<td>>10,000</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/H3_receptor" class="mw-redirect" title="H3 receptor">H<sub>3</sub></a></td>
<td>224</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/H4_receptor" class="mw-redirect" title="H4 receptor">H<sub>4</sub></a></td>
<td>>10,000</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/M1_receptor" class="mw-redirect" title="M1 receptor">M<sub>1</sub></a></td>
<td>6,780</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/M2_receptor" class="mw-redirect" title="M2 receptor">M<sub>2</sub></a></td>
<td>3,510</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/M3_receptor" class="mw-redirect" title="M3 receptor">M<sub>3</sub></a></td>
<td>4,680</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/M4_receptor" class="mw-redirect" title="M4 receptor">M<sub>4</sub></a></td>
<td>1,520</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/M5_receptor" class="mw-redirect" title="M5 receptor">M<sub>5</sub></a></td>
<td>2,330</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/Serotonin_transporter" title="Serotonin transporter"><abbr title="Serotonin transporter">SERT</abbr></a></td>
<td>98–1,080</td>
<td>Blocker</td>
</tr>
<tr>
<td><a href="/wiki/Norepinephrine_transporter" title="Norepinephrine transporter"><abbr title="Norepinephrine transporter">NET</abbr></a></td>
<td>2,090</td>
<td>Blocker</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_transporter" title="Dopamine transporter"><abbr title="Dopamine transporter">DAT</abbr></a></td>
<td>3,220</td>
<td>Blocker</td>
</tr>
<tr>
<td><a href="/wiki/NMDA_receptor" title="NMDA receptor"><abbr title="N-Methyl-D-aspartate receptor">NMDA</abbr><br>(<abbr title="Phencyclidine site">PCP</abbr>)</a></td>
<td>4,001</td>
<td>Antagonist</td>
</tr>
</tbody></table>
</td>
<td>Zyprexa
<br>
<table class="wikitable floatright" style="font-size:small;">
<tbody>
<tr>
<th>Site</th>
<th>K<sub>i</sub> (nM)</th>
<th>Action</th>
</tr>
<tr>
<td><a href="/wiki/5-HT1A_receptor" title="5-HT1A receptor">5-HT<sub>1A</sub></a></td>
<td>2,063–2,720</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/5-HT1B_receptor" title="5-HT1B receptor">5-HT<sub>1B</sub></a></td>
<td>509–660</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/5-HT1D_receptor" title="5-HT1D receptor">5-HT<sub>1D</sub></a></td>
<td>540–1,582</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/5-HT1E_receptor" title="5-HT1E receptor">5-HT<sub>1E</sub></a></td>
<td>2,010–2,408</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/5-HT1F_receptor" title="5-HT1F receptor">5-HT<sub>1F</sub></a></td>
<td>310</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">5-HT<sub>2A</sub></a></td>
<td>1.32–24.2</td>
<td>Inverse agonist</td>
</tr>
<tr>
<td><a href="/wiki/5-HT2B_receptor" title="5-HT2B receptor">5-HT<sub>2B</sub></a></td>
<td>11.8–12.0</td>
<td>Inverse agonist</td>
</tr>
<tr>
<td><a href="/wiki/5-HT2C_receptor" title="5-HT2C receptor">5-HT<sub>2C</sub></a></td>
<td>6.4–29</td>
<td>Inverse agonist</td>
</tr>
<tr>
<td><a href="/wiki/5-HT3_receptor" title="5-HT3 receptor">5-HT<sub>3</sub></a></td>
<td>202</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/5-HT5A_receptor" title="5-HT5A receptor">5-HT<sub>5A</sub></a></td>
<td>1,212</td>
<td>Full Agonist</td>
</tr>
<tr>
<td><a href="/wiki/5-HT6_receptor" title="5-HT6 receptor">5-HT<sub>6</sub></a></td>
<td>6.0–42</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/5-HT7_receptor" title="5-HT7 receptor">5-HT<sub>7</sub></a></td>
<td>105–365</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Alpha-1A_adrenergic_receptor" title="Alpha-1A adrenergic receptor" style="background:red;">α<sub>1A</sub></a></td>
<td>109–115</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Alpha-1B_adrenergic_receptor" title="Alpha-1B adrenergic receptor" style="background:red">α<sub>1B</sub></a></td>
<td>263</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Alpha-2A_adrenergic_receptor" title="Alpha-2A adrenergic receptor">α<sub>2A</sub></a></td>
<td>192–470</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Alpha-2B_adrenergic_receptor" title="Alpha-2B adrenergic receptor">α<sub>2B</sub></a></td>
<td>82–180</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Alpha-2C_adrenergic_receptor" title="Alpha-2C adrenergic receptor">α<sub>2C</sub></a></td>
<td>29–210</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Beta-1_adrenergic_receptor" title="Beta-1 adrenergic receptor">β<sub>1</sub></a></td>
<td>>10,000</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/Beta-2_adrenergic_receptor" title="Beta-2 adrenergic receptor">β<sub>2</sub></a></td>
<td>>10,000</td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D1_receptor" class="mw-redirect" title="Dopamine D1 receptor">D<sub>1</sub></a></td>
<td>35–118</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D2_receptor" class="mw-redirect" title="Dopamine D2 receptor">D<sub>2</sub></a></td>
<td>3.00–106</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D2_receptor" class="mw-redirect" title="Dopamine D2 receptor">D<sub>2L</sub></a></td>
<td>31–38</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D2_receptor" style="background:red" class="mw-redirect" title="Dopamine D2 receptor">D<sub>2S</sub></a></td>
<td>21–52</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D3_receptor" class="mw-redirect" title="Dopamine D3 receptor">D<sub>3</sub></a></td>
<td>7.8–91</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D4_receptor" class="mw-redirect" title="Dopamine D4 receptor">D<sub>4</sub></a></td>
<td>1.6–50</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D4_receptor" class="mw-redirect" title="Dopamine D4 receptor">D<sub>4.2</sub></a></td>
<td>17–102</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D4_receptor" class="mw-redirect" title="Dopamine D4 receptor">D<sub>4.4</sub></a></td>
<td>21–60</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D5_receptor" class="mw-redirect" title="Dopamine D5 receptor">D<sub>5</sub></a></td>
<td>74–90</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Histamine_H1_receptor" title="Histamine H1 receptor">H<sub>1</sub></a></td>
<td>0.65–4.9</td>
<td>Inverse agonist</td>
</tr>
<tr>
<td><a href="/wiki/Histamine_H2_receptor" title="Histamine H2 receptor">H<sub>2</sub></a></td>
<td>44</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Histamine_H3_receptor" title="Histamine H3 receptor">H<sub>3</sub></a></td>
<td>3,713</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Histamine_H4_receptor" title="Histamine H4 receptor">H<sub>4</sub></a></td>
<td>>10,000</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Muscarinic_acetylcholine_receptor_M1" title="Muscarinic acetylcholine receptor M1">M<sub>1</sub></a></td>
<td>2.5–73</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Muscarinic_acetylcholine_receptor_M2" title="Muscarinic acetylcholine receptor M2">M<sub>2</sub></a></td>
<td>48–622</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Muscarinic_acetylcholine_receptor_M3" title="Muscarinic acetylcholine receptor M3">M<sub>3</sub></a></td>
<td>13–126</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Muscarinic_acetylcholine_receptor_M4" title="Muscarinic acetylcholine receptor M4">M<sub>4</sub></a></td>
<td>10–350</td>
<td>Antagonist</td>
</tr>
<tr>
<td><a href="/wiki/Muscarinic_acetylcholine_receptor_M5" title="Muscarinic acetylcholine receptor M5">M<sub>5</sub></a></td>
<td>6.0–82</td>
<td>Antagonist</td>
</tr>
</tbody>
</table>
</td>
<td>Vraylar/Cariprazine (squashed banana)
<table class="wikitable floatleft" style="font-size:small;background:Crimson;">
<caption></caption>
<tbody>
<tr>
<th>Site</th>
<th>K<sub>i</sub> (nM)</th>
<th>Action
</th>
</tr>
<tr>
<td><a href="/wiki/5-HT1A_receptor" title="5-HT1A receptor">5-HT<sub>1A</sub></a></td>
<td>2.6</td>
<td>Partial agonist
</td>
</tr>
<tr>
<td><a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">5-HT<sub>2A</sub></a></td>
<td>18.8</td>
<td>Antagonist
</td>
</tr>
<tr>
<td><a href="/wiki/5-HT2B_receptor" title="5-HT2B receptor">5-HT<sub>2B</sub></a></td>
<td>0.58</td>
<td>Antagonist
</td>
</tr>
<tr>
<td><a href="/wiki/5-HT2C_receptor" title="5-HT2C receptor">5-HT<sub>2C</sub></a></td>
<td>134</td>
<td>Inverse agonist
</td>
</tr>
<tr>
<td><a href="/wiki/5-HT7_receptor" title="5-HT7 receptor">5-HT<sub>7</sub></a></td>
<td>111</td>
<td>Antagonist
</td>
</tr>
<tr>
<td><a href="/wiki/Alpha-1A_adrenergic_receptor" title="Alpha-1A adrenergic receptor">α<sub>1A</sub></a></td>
<td>155</td>
<td>Antagonist
</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D2_receptor" class="mw-redirect" title="Dopamine D2 receptor">D<sub>2L</sub></a></td>
<td>0.49</td>
<td>Partial agonist
</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D2_receptor" class="mw-redirect" title="Dopamine D2 receptor">D<sub>2S</sub></a></td>
<td>0.69</td>
<td>Partial agonist
</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D3_receptor" class="mw-redirect" title="Dopamine D3 receptor">D<sub>3</sub></a></td>
<td>0.085</td>
<td>Partial agonist
</td>
</tr>
<tr>
<td><a href="/wiki/Histamine_H1_receptor" title="Histamine H1 receptor">H<sub>1</sub></a></td>
<td>23.2</td>
<td>Antagonist
</td>
</tr>
<tr>
<td><a href="/wiki/Muscarinic_acetylcholine_receptor" title="Muscarinic acetylcholine receptor"><abbr title="Muscarinic acetylcholine receptor">mACh</abbr></a></td>
<td>>1,000</td>
<td>Antagonist
</td>
</tr>
</tbody>
</table>
</td>
</tr>
<tr>
<td>Haldol
<ul>
<li><a title="Dopamine receptor D1" href="https://en.wikipedia.org/wiki/Dopamine_receptor_D1">D<sub>1</sub></a> (silent antagonist) — Unknown efficiency<sup>[<i><a title="Wikipedia:Citation needed" href="https://en.wikipedia.org/wiki/Wikipedia:Citation_needed">citation needed</a></i>]</sup>
</li><li><a title="Dopamine receptor D5" href="https://en.wikipedia.org/wiki/Dopamine_receptor_D5">D<sub>5</sub></a> (silent antagonist) — Unknown efficiency<sup>[<i><a title="Wikipedia:Citation needed" href="https://en.wikipedia.org/wiki/Wikipedia:Citation_needed">citation needed</a></i>]</sup>
</li><li><a title="Dopamine receptor D2" href="https://en.wikipedia.org/wiki/Dopamine_receptor_D2">D<sub>2</sub></a> (inverse agonist) — 1.55 nM<sup id="cite_ref-44"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-44">[44]</a></sup>
</li><li><a title="Dopamine receptor D3" href="https://en.wikipedia.org/wiki/Dopamine_receptor_D3">D<sub>3</sub></a> (inverse agonist) — 0.74 nM<sup id="cite_ref-45"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-45">[45]</a></sup>
</li><li><a title="Dopamine receptor D4" href="https://en.wikipedia.org/wiki/Dopamine_receptor_D4">D<sub>4</sub></a> (inverse agonist) — 5–9 nM<sup id="cite_ref-46"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-46">[46]</a></sup>
</li><li><a title="Sigma-1 receptor" href="https://en.wikipedia.org/wiki/Sigma-1_receptor">σ<sub>1</sub></a> (irreversible inactivation by haloperidol) – 3 nM<sup id="cite_ref-47"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-47">[47]</a></sup></li><li><a title="Sigma-2 receptor" href="https://en.wikipedia.org/wiki/Sigma-2_receptor">σ<sub>2</sub></a> (agonist): 54 nM<sup id="cite_ref-48"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-48">[48]</a></sup>
</li><li><a title="5-HT1A receptor" href="https://en.wikipedia.org/wiki/5-HT1A_receptor">5HT<sub>1A</sub> receptor</a> agonist – 1927 nM<sup id="cite_ref-affindata_49-0"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-affindata-49">[49]</a></sup>
</li><li><a title="5-HT2A receptor" href="https://en.wikipedia.org/wiki/5-HT2A_receptor">5HT<sub>2A</sub></a> (silent antagonist) – 53 nM<sup id="cite_ref-affindata_49-1"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-affindata-49">[49]</a></sup>
</li><li><a title="5-HT2C receptor" href="https://en.wikipedia.org/wiki/5-HT2C_receptor">5HT<sub>2C</sub></a> (silent antagonist) – 10,000 nM<sup id="cite_ref-affindata_49-2"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-affindata-49">[49]</a></sup>
</li><li><a title="5-HT6 receptor" href="https://en.wikipedia.org/wiki/5-HT6_receptor">5HT<sub>6</sub></a> (silent antagonist) – 3666 nM<sup id="cite_ref-affindata_49-3"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-affindata-49">[49]</a></sup>
</li><li><a title="5-HT7 receptor" href="https://en.wikipedia.org/wiki/5-HT7_receptor">5HT<sub>7</sub></a> (irreversible silent antagonist) — 377.2 nM<sup id="cite_ref-affindata_49-4"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-affindata-49">[49]</a></sup>
</li><li><a title="Histamine H1 receptor" href="https://en.wikipedia.org/wiki/Histamine_H1_receptor">H<sub>1</sub></a> (silent antagonist) — 1,800 nM<sup id="cite_ref-affindata_49-5"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-affindata-49">[49]</a></sup>
</li><li><a title="Muscarinic acetylcholine receptor M1" href="https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M1">M<sub>1</sub></a> (silent antagonist) — 10,000 nM<sup id="cite_ref-affindata_49-6"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-affindata-49">[49]</a></sup>
</li><li><a title="Alpha-1A adrenergic receptor" href="https://en.wikipedia.org/wiki/Alpha-1A_adrenergic_receptor">α<sub>1A</sub></a> (silent antagonist) — 12 nM<sup id="cite_ref-affindata_49-7"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-affindata-49">[49]</a></sup>
</li><li><a title="Alpha-2A adrenergic receptor" href="https://en.wikipedia.org/wiki/Alpha-2A_adrenergic_receptor">α<sub>2A</sub></a> (silent antagonist) — 1130 nM<sup id="cite_ref-affindata_49-8"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-affindata-49">[49]</a></sup>
</li><li><a title="Alpha-2B adrenergic receptor" href="https://en.wikipedia.org/wiki/Alpha-2B_adrenergic_receptor">α<sub>2B</sub></a> (silent antagonist) — 480 nM<sup id="cite_ref-affindata_49-9"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-affindata-49">[49]</a></sup>
</li><li><a title="Alpha-2C adrenergic receptor" href="https://en.wikipedia.org/wiki/Alpha-2C_adrenergic_receptor">α<sub>2C</sub></a> (silent antagonist) — 550 nM<sup id="cite_ref-affindata_49-10"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-affindata-49">[49]</a></sup>
</li><li>NR1/NR2B subunit containing <a title="NMDA receptor" href="https://en.wikipedia.org/wiki/NMDA_receptor">NMDA receptor<br>
</a> (antagonist; <a title="Ifenprodil" href="https://en.wikipedia.org/wiki/Ifenprodil">ifenprodil</a> site): <a title="IC50" href="https://en.wikipedia.org/wiki/IC50">IC<sub>50</sub></a> — 2,000 nM<sup id="cite_ref-50"><a href="https://en.wikipedia.org/wiki/Haloperidol#cite_note-50">[50]</a></sup>
</li></ul>
</td>
<td>
Cymbalta
<table>
<tbody>
<tr>
<td><a href="/wiki/Serotonin_transporter" title="Serotonin transporter">SERT</a></td>
<td>0.8</td>
</tr>
<tr>
<td><a href="/wiki/Norepinephrine_transporter" title="Norepinephrine transporter">NET</a></td>
<td>7.5
</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_transporter" title="Dopamine transporter">DAT</a></td>
<td>240
</td>
</tr>
<tr>
<td><a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">5-HT<sub>2A</sub></a></td>
<td>504
</td>
</tr>
<tr>
<td><a href="/wiki/5-HT2C_receptor" title="5-HT2C receptor">5-HT<sub>2C</sub></a></td>
<td>916
</td>
</tr>
<tr>
<td><a href="/wiki/5-HT6_receptor" title="5-HT6 receptor">5-HT<sub>6</sub></a></td>
<td>419
</td>
</tr></tbody></table>
</td>
<td><table class="wikitable floatright" style="font-size:small;">
<caption>Trazodone (and metabolite)<sup id="cite_ref-PDSP_43-0" class="reference"><a href="#cite_note-PDSP-43">[43]</a></sup>
</caption>
<tbody><tr>
<th>Site</th>
<th>Trazodone</th>
<th><a href="/wiki/Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine"><abbr title="meta-Chlorophenylpiperazine">mCPP</abbr></a></th>
<th>Species</th>
</tr>
<tr>
<td><b><a href="/wiki/Serotonin_transporter" title="Serotonin transporter"><abbr title="Serotonin transporter">SERT</abbr></a></b></td>
<td><b>160–>10,000<sup id="cite_ref-44" class="reference"><a href="#cite_note-44">[44]</a></sup></b></td>
<td><b>202–432</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><a href="/wiki/Norepinephrine_transporter" title="Norepinephrine transporter"><abbr title="Norepinephrine transporter">NET</abbr></a></td>
<td>≥8,500</td>
<td>≥1,940</td>
<td>Human</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_transporter" title="Dopamine transporter"><abbr title="Dopamine transporter">DAT</abbr></a></td>
<td>≥7,400</td>
<td><abbr title="No data">ND</abbr></td>
<td>Human</td>
</tr>
<tr>
<td><b><a href="/wiki/5-HT1A_receptor" title="5-HT1A receptor">5-HT<sub>1A</sub></a></b></td>
<td><b>96–118</b></td>
<td><b>44–400</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><b><a href="/wiki/5-HT1B_receptor" title="5-HT1B receptor">5-HT<sub>1B</sub></a></b></td>
<td>>10,000</td>
<td><b>89–501</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><b><a href="/wiki/5-HT1D_receptor" title="5-HT1D receptor">5-HT<sub>1D</sub></a></b></td>
<td><b>106</b></td>
<td><b>210–1,300</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><a href="/wiki/5-HT1E_receptor" title="5-HT1E receptor">5-HT<sub>1E</sub></a></td>
<td>>10,000</td>
<td><abbr title="No data">ND</abbr></td>
<td>Human</td>
</tr>
<tr>
<td><a href="/wiki/5-HT1F_receptor" title="5-HT1F receptor">5-HT<sub>1F</sub></a></td>
<td><abbr title="No data">ND</abbr></td>
<td><abbr title="No data">ND</abbr></td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><b><a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">5-HT<sub>2A</sub></a></b></td>
<td><b>20–45</b></td>
<td><b>32–398</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><b><a href="/wiki/5-HT2B_receptor" title="5-HT2B receptor">5-HT<sub>2B</sub></a></b></td>
<td><b>74–189</b></td>
<td><b>3.2–63</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><b><a href="/wiki/5-HT2C_receptor" title="5-HT2C receptor">5-HT<sub>2C</sub></a></b></td>
<td><b>224–402</b></td>
<td><b>3.4–251</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><a href="/wiki/5-HT3_receptor" title="5-HT3 receptor">5-HT<sub>3</sub></a></td>
<td>>10,000</td>
<td>427</td>
<td>Human</td>
</tr>
<tr>
<td><a href="/wiki/5-HT4_receptor" title="5-HT4 receptor">5-HT<sub>4</sub></a></td>
<td><abbr title="No data">ND</abbr></td>
<td><abbr title="No data">ND</abbr></td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><a href="/wiki/5-HT5A_receptor" title="5-HT5A receptor">5-HT<sub>5A</sub></a></td>
<td>>10,000</td>
<td>1,354</td>
<td>Human</td>
</tr>
<tr>
<td><a href="/wiki/5-HT6_receptor" title="5-HT6 receptor">5-HT<sub>6</sub></a></td>
<td>>10,000</td>
<td>1,748</td>
<td>Human</td>
</tr>
<tr>
<td><b><a href="/wiki/5-HT7_receptor" title="5-HT7 receptor">5-HT<sub>7</sub></a></b></td>
<td>1,782</td>
<td><b>163</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><b><a href="/wiki/Alpha-1_adrenergic_receptor" title="Alpha-1 adrenergic receptor">α<sub>1</sub></a></b></td>
<td><b>12–42</b></td>
<td><b>97–2,900</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><b> <a href="/wiki/Alpha-1A_adrenergic_receptor" title="Alpha-1A adrenergic receptor">α<sub>1A</sub></a></b></td>
<td><b>153</b></td>
<td><b>1,386</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td> <a href="/wiki/Alpha-1B_adrenergic_receptor" title="Alpha-1B adrenergic receptor">α<sub>1B</sub></a></td>
<td><abbr title="No data">ND</abbr></td>
<td>915</td>
<td>Human</td>
</tr>
<tr>
<td> <a href="/wiki/Alpha-1D_adrenergic_receptor" title="Alpha-1D adrenergic receptor">α<sub>1D</sub></a></td>
<td><abbr title="No data">ND</abbr></td>
<td><abbr title="No data">ND</abbr></td>
<td><abbr title="No data">ND</abbr></td>
</tr>
<tr>
<td><b><a href="/wiki/Alpha-2_adrenergic_receptor" title="Alpha-2 adrenergic receptor">α<sub>2</sub></a></b></td>
<td><b>106–490</b></td>
<td><b>112–570</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><b> <a href="/wiki/Alpha-2A_adrenergic_receptor" title="Alpha-2A adrenergic receptor">α<sub>2A</sub></a></b></td>
<td>728</td>
<td><b>145</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><b> <a href="/wiki/Alpha-2B_adrenergic_receptor" title="Alpha-2B adrenergic receptor">α<sub>2B</sub></a></b></td>
<td><abbr title="No data">ND</abbr></td>
<td><b>106</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><b> <a href="/wiki/Alpha-2C_adrenergic_receptor" title="Alpha-2C adrenergic receptor">α<sub>2C</sub></a></b></td>
<td><b>155</b></td>
<td><b>124</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><a href="/wiki/Beta_adrenergic_receptor" class="mw-redirect" title="Beta adrenergic receptor">β</a></td>
<td>>10,000</td>
<td>2,500</td>
<td>Human</td>
</tr>
<tr>
<td> <a href="/wiki/Beta-1_adrenergic_receptor" title="Beta-1 adrenergic receptor">β<sub>1</sub></a></td>
<td>>10,000</td>
<td>2,359</td>
<td>Human</td>
</tr>
<tr>
<td> <a href="/wiki/Beta-2_adrenergic_receptor" title="Beta-2 adrenergic receptor">β<sub>2</sub></a></td>
<td>>10,000</td>
<td>3,474</td>
<td>Human</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D1_receptor" class="mw-redirect" title="Dopamine D1 receptor">D<sub>1</sub></a></td>
<td>3,730</td>
<td>7,000</td>
<td>Human</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D2_receptor" class="mw-redirect" title="Dopamine D2 receptor">D<sub>2</sub></a></td>
<td>≥3,500</td>
<td>>10,000</td>
<td>Human</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D3_receptor" class="mw-redirect" title="Dopamine D3 receptor">D<sub>3</sub></a></td>
<td>353</td>
<td>>10,000</td>
<td>Rat</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D4_receptor" class="mw-redirect" title="Dopamine D4 receptor">D<sub>4</sub></a></td>
<td>703</td>
<td><abbr title="No data">ND</abbr></td>
<td>Human</td>
</tr>
<tr>
<td><a href="/wiki/Dopamine_D5_receptor" class="mw-redirect" title="Dopamine D5 receptor">D<sub>5</sub></a></td>
<td>>10,000</td>
<td>>10,000</td>
<td>Human</td>
</tr>
<tr>
<td><b><a href="/wiki/Histamine_H1_receptor" title="Histamine H1 receptor">H<sub>1</sub></a></b></td>
<td><b>220–1,100</b></td>
<td><b>326</b></td>
<td><b>Human</b></td>
</tr>
<tr>
<td><a href="/wiki/Histamine_H2_receptor" title="Histamine H2 receptor">H<sub>2</sub></a></td>
<td>3,290</td>
<td><abbr title="No data">ND</abbr></td>
<td>Human</td>
</tr>
<tr>
<td><a href="/wiki/Histamine_H3_receptor" title="Histamine H3 receptor">H<sub>3</sub></a></td>
<td>>10,000</td>
<td><abbr title="No data">ND</abbr></td>
<td>Guinea pig</td>
</tr>
<tr>
<td><a href="/wiki/Histamine_H4_receptor" title="Histamine H4 receptor">H<sub>4</sub></a></td>
<td>>10,000</td>
<td><abbr title="No data">ND</abbr></td>
<td>Human</td>
</tr>
<tr>
<td><a href="/wiki/Muscarinic_acetylcholine_receptors" class="mw-redirect" title="Muscarinic acetylcholine receptors"><abbr title="Muscarinic acetylcholine receptors">mAChRs</abbr></a></td>
<td>>10,000</td>
<td>>10,000</td>
<td>Human</td>
</tr>
<tr>
<td><a href="/wiki/Nicotinic_acetylcholine_receptors" class="mw-redirect" title="Nicotinic acetylcholine receptors"><abbr title="Nicotinic acetylcholine receptors">nAChRs</abbr></a></td>
<td>>10,000</td>
<td>>10,000</td>
<td>Human</td>
</tr>
<tr>
<td><a href="/wiki/Sigma-1_receptor" title="Sigma-1 receptor">σ<sub>1</sub></a></td>
<td>>10,000</td>
<td><abbr title="No data">ND</abbr></td>
<td>Rat</td>
</tr>
<tr>
<td><a href="/wiki/Sigma-2_receptor" title="Sigma-2 receptor">σ<sub>2</sub></a></td>
<td>536</td>
<td>8,350</td>
<td>Rat</td>
</tr>
<tr>
<td><a href="/wiki/Imidazoline_receptor" title="Imidazoline receptor">I<sub>1</sub></a></td>
<td><abbr title="No data">ND</abbr></td>
<td>759</td>
<td>Rat</td>
</tr>
<tr>
<td><a href="/wiki/NMDA_receptor" title="NMDA receptor"><abbr title="N-Methyl-D-aspartate receptor">NMDAR</abbr><br>(MK-801)</a></td>
<td>>10,000</td>
<td><abbr title="No data">ND</abbr></td>
<td>Rat</td>
</tr>
<tr>
<td><a href="/wiki/Voltage-dependent_calcium_channels" class="mw-redirect" title="Voltage-dependent calcium channels"><abbr title="Voltage-dependent calcium channels">VDCCs</abbr></a></td>
<td>>10,000</td>
<td>6,043</td>
<td>Rat</td>
</tr>
</tbody></table></td>
</tr>
<tr>
<td><table class="wikitable floatright">
<caption>Risperidone</caption>
<tbody><tr>
<th>Site</th>
<th>K<sub>i</sub> (nM)</th>
<th>Action
</th></tr>
<tr>
<td><a href="/wiki/5-HT1A_receptor" title="5-HT1A receptor">5-HT<sub>1A</sub></a></td>
<td>423</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/5-HT1B_receptor" title="5-HT1B receptor">5-HT<sub>1B</sub></a></td>
<td>14.9</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/5-HT1D_receptor" title="5-HT1D receptor">5-HT<sub>1D</sub></a></td>
<td>84.6</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">5-HT<sub>2A</sub></a></td>
<td>0.17</td>
<td>Inverse agonist
</td></tr>
<tr>
<td><a href="/wiki/5-HT2B_receptor" title="5-HT2B receptor">5-HT<sub>2B</sub></a></td>
<td>61.9</td>
<td>Inverse agonist
</td></tr>
<tr>
<td><a href="/wiki/5-HT2C_receptor" title="5-HT2C receptor">5-HT<sub>2C</sub></a></td>
<td>12.0</td>
<td>Inverse agonist
</td></tr>
<tr>
<td><a href="/wiki/5-HT5A_receptor" title="5-HT5A receptor">5-HT<sub>5A</sub></a></td>
<td>206</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/5-HT6_receptor" title="5-HT6 receptor">5-HT<sub>6</sub></a></td>
<td>2,060</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/5-HT7_receptor" title="5-HT7 receptor">5-HT<sub>7</sub></a></td>
<td>6.60</td>
<td>Irreversible<br>
antagonist<wbr></td></tr>
<tr>
<td><a href="/wiki/Alpha-1A_adrenergic_receptor" title="Alpha-1A adrenergic receptor">α<sub>1A</sub></a></td>
<td>5.0</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/Alpha-1B_adrenergic_receptor" title="Alpha-1B adrenergic receptor">α<sub>1B</sub></a></td>
<td>9.0</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/Alpha-2A_adrenergic_receptor" title="Alpha-2A adrenergic receptor">α<sub>2A</sub></a></td>
<td>16.5</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/Alpha-2B_adrenergic_receptor" title="Alpha-2B adrenergic receptor">α<sub>2B</sub></a></td>
<td>108</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/Alpha-2C_adrenergic_receptor" title="Alpha-2C adrenergic receptor">α<sub>2C</sub></a></td>
<td>1.30</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/D1_receptor" class="mw-redirect" title="D1 receptor">D<sub>1</sub></a></td>
<td>244</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/D2_receptor" class="mw-redirect" title="D2 receptor">D<sub>2</sub></a></td>
<td>3.57</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/D2_receptor" class="mw-redirect" title="D2 receptor">D<sub>2S</sub></a></td>
<td>4.73</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/D2_receptor" class="mw-redirect" title="D2 receptor">D<sub>2L</sub></a></td>
<td>4.16</td>
<td>Antagonist
</td></tr>
<tr>
<td><a href="/wiki/D3_receptor" class="mw-redirect" title="D3 receptor">D<sub>3</sub></a></td>
<td>3.6</td>
<td>Inverse agonist
</td></tr>
<tr>
<td><a href="/wiki/D4_receptor" class="mw-redirect" title="D4 receptor">D<sub>4</sub></a></td>
<td>4.66</td>
<td>Antagonist
</td></tr>
<tr>